NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|967493426|ref|XP_014978274|]
View 

cyclin-dependent kinase 4 inhibitor D isoform X1 [Macaca mulatta]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-161 1.55e-29

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 1.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRElVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVL 93
Cdd:COG0666   94 AARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967493426  94 VEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
Cdd:COG0666  173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLlEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-161 1.55e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 1.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRElVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVL 93
Cdd:COG0666   94 AARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967493426  94 VEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
Cdd:COG0666  173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLlEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-158 6.09e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 6.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   79 HDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAESDLhRRDARGLTPLELALQRGAQDLVDIL 158
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-NLKDNGRTALHYAARSGHLEIVKLL 80
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-147 7.12e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 7.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDAR 138
Cdd:PHA02874 143 LFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHgNHIMNKCKN 222


                 ....*....
gi 967493426 139 GLTPLELAL 147
Cdd:PHA02874 223 GFTPLHNAI 231
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 15-148 1.40e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.71  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKqgASP---NVQDTS----GTSPVHDAARTGF 86
Cdd:cd22192   24 AAKENDVQAIKKLLKCPSCDLFQRGALGETALHVaALYDNLEAAVVLME--AAPelvNEPMTSdlyqGETALHIAVVNQN 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967493426  87 LDTLKVLVEHGADVNAPDGTGAL--------------PIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLE-LALQ 148
Cdd:cd22192  102 LNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLiEHGADIRAQDSLGNTVLHiLVLQ 179
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 74-102 4.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 4.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 967493426    74 GTSPVHDAARTGFLDTLKVLVEHGADVNA 102
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 10-102 3.07e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 37.37  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   10 DRLSGAAARGDVQEVRRLLHRElvhpDALNRFGKTALQVMMF----GSTAIALELL----KQGASPNVQD------TSGT 75
Cdd:TIGR00870  54 SALFVAAIENENLELTELLLNL----SCRGAVGDTLLHAISLeyvdAVEAILLHLLaafrKSGPLELANDqytsefTPGI 129

                          90       100
                  ....*....|....*....|....*..
gi 967493426   76 SPVHDAARTGFLDTLKVLVEHGADVNA 102
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPA 156
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-161 1.55e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 1.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRElVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVL 93
Cdd:COG0666   94 AARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967493426  94 VEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
Cdd:COG0666  173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLlEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-158 4.16e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 100.41  E-value: 4.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVL 93
Cdd:COG0666   60 AAALAGDLLVALLLLAAGADINAKDDGGNTLLhAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 967493426  94 VEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
Cdd:COG0666  140 LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLlEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-158 2.87e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  11 RLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTL 90
Cdd:COG0666   24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967493426  91 KVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDIL 158
Cdd:COG0666  104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLlEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-158 6.09e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 6.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   79 HDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAESDLhRRDARGLTPLELALQRGAQDLVDIL 158
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV-NLKDNGRTALHYAARSGHLEIVKLL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-136 4.40e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 4.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   50 MFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHgADVNAPDGtGALPIHLAVQEGHTAVVSFLAA- 128
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEk 83


                  ....*...
gi 967493426  129 ESDLHRRD 136
Cdd:pfam12796  84 GADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-143 4.56e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 4.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  12 LSGAAARGDVQEVRRLLHRElVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTL 90
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLaAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 967493426  91 KVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPL 143
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-147 7.12e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 7.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDAR 138
Cdd:PHA02874 143 LFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHgNHIMNKCKN 222


                 ....*....
gi 967493426 139 GLTPLELAL 147
Cdd:PHA02874 223 GFTPLHNAI 231
Ank_2 pfam12796
Ankyrin repeats (3 copies);
12-104 4.24e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 4.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   12 LSGAAARGDVQEVRRLLHRElVHPDALNRFGKTALQV-MMFGSTAIALELLKQgASPNVQDtSGTSPVHDAARTGFLDTL 90
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLaAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 967493426   91 KVLVEHGADVNAPD 104
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-143 5.36e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 5.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  16 AARGDVQEVRRLLHRElvhPDALNR--FGKTALQVMMFGS----TAIALELLKQGASPNVQDTSGTSPVHDAARTGF-LD 88
Cdd:PHA03095  22 ASNVTVEEVRRLLAAG---ADVNFRgeYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLD 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 967493426  89 TLKVLVEHGADVNAPDGTG--ALPIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPL 143
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGrtPLHVYLSGFNINPKVIRLLlRKGADVNALDLYGMTPL 156
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-161 9.71e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.82  E-value: 9.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTaVVSFLAAESDLHRRDARG 139
Cdd:PHA02874 176 LLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNASINDQDIDG 254

                         90       100
                 ....*....|....*....|...
gi 967493426 140 LTPLELALQRG-AQDLVDILQGH 161
Cdd:PHA02874 255 STPLHHAINPPcDIDIIDILLYH 277
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 12-158 1.10e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.85  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTL 90
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLaTILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967493426  91 KVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL---AAESDLHRRDArGLTPLELALQRGAQDLVDIL 158
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLldsGANIDYFGKNG-CVAALCYAIENNKIDIVRLF 221
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 46-158 1.38e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.73  E-value: 1.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  46 LQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSF 125
Cdd:PLN03192 530 LTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRI 609

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967493426 126 L---AAESDLH----------RR-------------------DARGLTPLELALQRGAQDLVDIL 158
Cdd:PLN03192 610 LyhfASISDPHaagdllctaaKRndltamkellkqglnvdseDHQGATALQVAMAEDHVDMVRLL 674
Ank_4 pfam13637
Ankyrin repeats (many copies);
74-126 7.90e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 7.90e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 967493426   74 GTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL 126
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 23-156 1.83e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.42  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  23 EVRRLLHRELVHPDALNRFGKTALQVMMFG---STAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKV--LVEHG 97
Cdd:PHA03095 168 ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkpRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAG 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  98 ADVNAPDGTGALPIHLA-VQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVD 156
Cdd:PHA03095 248 ISINARNRYGQTPLHYAaVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 52-161 2.61e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.90  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  52 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAESD 131
Cdd:PTZ00322  93 GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQ 172

                         90       100       110
                 ....*....|....*....|....*....|.
gi 967493426 132 LHRR-DARGlTPLELALQRGAQDLVDILQGH 161
Cdd:PTZ00322 173 CHFElGANA-KPDSFTGKPPSLEDSPISSHH 202
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-148 9.11e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.10  E-value: 9.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  19 GDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELL-KQGASPNVQDTSGTSPVHDAARTGFLD--TLKVLV 94
Cdd:PHA03095  60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLiKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLL 139

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 967493426  95 EHGADVNAPDGTGALPIHLAVQEGHT--AVVSFL-AAESDLHRRDARGLTPLELALQ 148
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLiDAGADVYAVDDRFRSLLHHHLQ 196
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 15-148 1.40e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 52.71  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKqgASP---NVQDTS----GTSPVHDAARTGF 86
Cdd:cd22192   24 AAKENDVQAIKKLLKCPSCDLFQRGALGETALHVaALYDNLEAAVVLME--AAPelvNEPMTSdlyqGETALHIAVVNQN 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 967493426  87 LDTLKVLVEHGADVNAPDGTGAL--------------PIHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLE-LALQ 148
Cdd:cd22192  102 LNLVRELIARGADVVSPRATGTFfrpgpknliyygehPLSFAACVGNEEIVRLLiEHGADIRAQDSLGNTVLHiLVLQ 179
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 60-161 1.17e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.96  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDAR 138
Cdd:PHA02874 110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKgAYANVKDNN 189

                         90       100
                 ....*....|....*....|...
gi 967493426 139 GLTPLELALQRGAQDLVDILQGH 161
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDH 212
Ank_5 pfam13857
Ankyrin repeats (many copies);
93-146 2.01e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 2.01e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 967493426   93 LVEHG-ADVNAPDGTGALPIHLAVQEGH-TAVVSFLAAESDLHRRDARGLTPLELA 146
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGAlEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 54-148 2.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.11  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  54 TAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQE--GHTAVVSFLAAESD 131
Cdd:PHA02878 181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYckDYDILKLLLEHGVD 260

                         90
                 ....*....|....*...
gi 967493426 132 LHRRDA-RGLTPLELALQ 148
Cdd:PHA02878 261 VNAKSYiLGLTALHSSIK 278
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-159 1.17e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGF-----LDTLKVLVEHGADVNAPDGTGALPIHLAVQE--GHTAVVSFLAAE-SD 131
Cdd:PHA03100  54 LLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNgAN 133

                         90       100
                 ....*....|....*....|....*...
gi 967493426 132 LHRRDARGLTPLELALQRGAQDLvDILQ 159
Cdd:PHA03100 134 VNIKNSDGENLLHLYLESNKIDL-KILK 160
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 49-158 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.91  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  49 MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGA--DVNAPDGTGalPIHLAVQEGHTAVVSFL 126
Cdd:PHA02875  10 ILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEEL 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 967493426 127 AAE----SDLHRRDarGLTPLELALQRGAQDLVDIL 158
Cdd:PHA02875  88 LDLgkfaDDVFYKD--GMTPLHLATILKKLDIMKLL 121
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-126 3.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 3.05e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFL 126
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 15-127 3.14e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRELvHPDALNRFGKTALQVMMF-GSTAIALELLKQGASPNVQDTSGTSPVHDA------------ 81
Cdd:PLN03192 532 VASTGNAALLEELLKAKL-DPDIGDSKGRTPLHIAASkGYEDCVLVLLKHACNVHIRDANGNTALWNAisakhhkifril 610

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967493426  82 -------------------ARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLA 127
Cdd:PLN03192 611 yhfasisdphaagdllctaAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 20-146 6.84e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 6.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  20 DVQEVRRLLHRELVHPDALNRFGKTALQVMM---FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGF--LDTLKVLV 94
Cdd:PHA03100  84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAIskkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLI 163

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967493426  95 EHGADVNA----------------PDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRRDARGLTPLELA 146
Cdd:PHA03100 164 DKGVDINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVKyLLDLGANPNLVNKYGDTPLHIA 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 54-149 7.28e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 7.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  54 TAIALELLKQGASPNVQD-TSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAE-SD 131
Cdd:PHA02878 147 AEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENgAS 226

                         90
                 ....*....|....*...
gi 967493426 132 LHRRDARGLTPLELALQR 149
Cdd:PHA02878 227 TDARDKCGNTPLHISVGY 244
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 57-159 2.37e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  57 ALELLKQGASPNVQDTSGTSPVHDAARTGFLDTL-KVLVEHGADVNAPDGTGALPIHLAVQEGHTA--VVSFLAAESDLH 133
Cdd:PHA02876 256 SLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYDTenIRTLIMLGADVN 335

                         90       100
                 ....*....|....*....|....*...
gi 967493426 134 RRDARGLTPLELA--LQRGAQDLVDILQ 159
Cdd:PHA02876 336 AADRLYITPLHQAstLDRNKDIVITLLE 363
PHA02946 PHA02946
ankyin-like protein; Provisional
 59-112 5.43e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 42.35  E-value: 5.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967493426  59 ELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIH 112
Cdd:PHA02946  57 ELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLY 110
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 11-143 8.16e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.72  E-value: 8.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  11 RLSGAAARGDVQEV-----------RRLLHRELVHPDAlnrfGKTALQVMMFG-------STAIALEL------LKQGAS 66
Cdd:cd22196    9 RIFDAVAKGDCKELdglleylmrtkKRLTDSEFKDPET----GKTCLLKAMLNlhngqndTISLLLDIaektgnLKEFVN 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  67 PNVQDT--SGTSPVHDAARTGFLDTLKVLVEHGADVNA-PDGT-------------GALPIHLAVQEGHTAVVSFLA--- 127
Cdd:cd22196   85 AAYTDSyyKGQTALHIAIERRNMHLVELLVQNGADVHArASGEffkkkkggpgfyfGELPLSLAACTNQLDIVKFLLenp 164

                        170
                 ....*....|....*..
gi 967493426 128 -AESDLHRRDARGLTPL 143
Cdd:cd22196  165 hSPADISARDSMGNTVL 181
Ank_5 pfam13857
Ankyrin repeats (many copies);
60-114 9.31e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 967493426   60 LLKQG-ASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLA 114
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 36-117 1.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  36 DALNRFGKTALQ--VMMFGSTAIALELLKQGASPNVQDT-SGTSPVHDAARTGflDTLKVLVEHGADVNAPDGTGALPIH 112
Cdd:PHA02878 228 DARDKCGNTPLHisVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLS 305


                 ....*
gi 967493426 113 LAVQE 117
Cdd:PHA02878 306 SAVKQ 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
111-162 2.97e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 2.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 967493426  111 IHLAVQEGHTAVVSFL-AAESDLHRRDARGLTPLELALQRGAQDLVDILQGHM 162
Cdd:pfam12796   1 LHLAAKNGNLELVKLLlENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 60-106 3.02e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 3.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 967493426  60 LLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGT 106
Cdd:PHA03100 211 LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-126 3.50e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  24 VRRLLHRElVHPDALNRFGKTALQVMMFG--STAIALELLKQGASPNVQDTSGTSPVHDAARTG-FLDTLKVLVEHGADV 100
Cdd:PHA02876 290 VPKLLERG-ADVNAKNIKGETPLYLMAKNgyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANV 368

                         90       100
                 ....*....|....*....|....*.
gi 967493426 101 NAPDGTGALPIHLAVQEGHTAVVSFL 126
Cdd:PHA02876 369 NARDYCDKTPIHYAAVRNNVVIINTL 394
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 15-141 4.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  15 AAARGDVQEVRRLLHRElVHPDALNRFGKTALQVMMFGSTAI--ALELLKQGASPNVQDTSGTSPVHDAARTGF-LDTLK 91
Cdd:PHA02876 382 AAVRNNVVIINTLLDYG-ADIEALSQKIGTALHFALCGTNPYmsVKTLIDRGANVNSKNKDLSTPLHYACKKNCkLDVIE 460

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 967493426  92 VLVEHGADVNAPDGTGALPIHLAVqEGHTAVVSFLAAESDLhrRDARGLT 141
Cdd:PHA02876 461 MLLDNGADVNAINIQNQYPLLIAL-EYHGIVNILLHYGAEL--RDSRVLH 507
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 56-101 4.11e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 4.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 967493426  56 IALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVN 101
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVN 205
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 74-102 4.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 4.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 967493426    74 GTSPVHDAARTGFLDTLKVLVEHGADVNA 102
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 57-116 8.16e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.79  E-value: 8.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967493426  57 ALELLKQGASPNVQDTSGTSPVHDAARTGF-LDTLKVLVEHGADVNAPDGTGALPIHLAVQ 116
Cdd:PHA02874 237 AIELLINNASINDQDIDGSTPLHHAINPPCdIDIIDILLYHKADISIKDNKGENPIDTAFK 297
PHA02741 PHA02741
hypothetical protein; Provisional
 68-159 1.91e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 36.94  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  68 NVQDTSGTSPVHDAARTG----FLDTLKVLVEHGADVNAPDG-TGALPIHLAVQEGHTAVVSFLAAES--DLHRRDARGL 140
Cdd:PHA02741  54 NATDDAGQMCIHIAAEKHeaqlAAEIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCCQPgiDLHFCNADNK 133

                         90
                 ....*....|....*....
gi 967493426 141 TPLELALQRGAQDLVDILQ 159
Cdd:PHA02741 134 SPFELAIDNEDVAMMQILR 152
Ank_4 pfam13637
Ankyrin repeats (many copies);
49-94 2.84e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 967493426   49 MMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94
Cdd:pfam13637   9 AASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 8-66 3.00e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 37.15  E-value: 3.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   8 SGDRLSGAAARGDVQEVRRLLHRELvHPDALNRFGKTALQVMMF-GSTAIALELLKQGAS 66
Cdd:PLN03192 622 AGDLLCTAAKRNDLTAMKELLKQGL-NVDSEDHQGATALQVAMAeDHVDMVRLLIMNGAD 680
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 10-102 3.07e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 37.37  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426   10 DRLSGAAARGDVQEVRRLLHRElvhpDALNRFGKTALQVMMF----GSTAIALELL----KQGASPNVQD------TSGT 75
Cdd:TIGR00870  54 SALFVAAIENENLELTELLLNL----SCRGAVGDTLLHAISLeyvdAVEAILLHLLaafrKSGPLELANDqytsefTPGI 129

                          90       100
                  ....*....|....*....|....*..
gi 967493426   76 SPVHDAARTGFLDTLKVLVEHGADVNA 102
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPA 156
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 91-155 3.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.35  E-value: 3.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 967493426  91 KVLVEHGADVNAPDGTGALPIHLAVQEGHTAVVSFLAAE-SDLHRRDARGLTPLELALQRGAQDLV 155
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgADVNIIALDDLSVLECAVDSKNIDTI 227
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 74-156 3.89e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 36.70  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  74 GTSPVHDAARTGFLDTLKVLVEHGADVNA----------PDGT----GALPIHLAVQEGHTAVVSFLAAES----DLHRR 135
Cdd:cd22193   76 GQTALHIAIERRQGDIVALLVENGADVHAhakgrffqpkYQGEgfyfGELPLSLAACTNQPDIVQYLLENEhqpaDIEAQ 155

                         90       100
                 ....*....|....*....|.
gi 967493426 136 DARGLTPLElALQRGAQDLVD 156
Cdd:cd22193  156 DSRGNTVLH-ALVTVADNTKE 175
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 74-104 3.92e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.42  E-value: 3.92e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 967493426   74 GTSPVHDAA-RTGFLDTLKVLVEHGADVNAPD 104
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 16-96 4.19e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 36.80  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  16 AARGDVQEVRRLLHRElVHPDALNRFGKTALQVM-MFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94
Cdd:PTZ00322  90 AASGDAVGARILLTGG-ADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168


                 ..
gi 967493426  95 EH 96
Cdd:PTZ00322 169 RH 170
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 56-158 4.31e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.58  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  56 IALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAV--QEGHTAVVSFLAAESDLH 133
Cdd:PHA02876 357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALcgTNPYMSVKTLIDRGANVN 436

                         90       100
                 ....*....|....*....|....*.
gi 967493426 134 RRDARGLTPLELALQRGAQ-DLVDIL 158
Cdd:PHA02876 437 SKNKDLSTPLHYACKKNCKlDVIEML 462
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 71-158 4.40e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 36.77  E-value: 4.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493426  71 DTSGTSPVHDAARTGFLDTLKVLVEHGADVNAPDGTGALPIHLAVQEGHT-AVVSFLAAESDLHRRDARGLTPLELALQR 149
Cdd:PLN03192 522 DPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEdCVLVLLKHACNVHIRDANGNTALWNAISA 601


                 ....*....
gi 967493426 150 GAQDLVDIL 158
Cdd:PLN03192 602 KHHKIFRIL 610
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH