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Conserved domains on  [gi|967493111|ref|XP_014978256|]
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zinc finger protein 317 isoform X3 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-476 3.37e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 129 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 182
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 183 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 234
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 235 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 313
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 314 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 381
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 382 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 450
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493111 451 NLNVHRRIHTGEKPYECLVCGKAFSD 476
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-476 3.37e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 129 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 182
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 183 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 234
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 235 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 313
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 314 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 381
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 382 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 450
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493111 451 NLNVHRRIHTGEKPYECLVCGKAFSD 476
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....
gi 967493111  424 LKTHMRSHTGEKPYECDHCGKAFS 447
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 155-207 1.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967493111 155 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 207
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-476 3.37e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 129 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 182
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 183 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 234
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 235 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 313
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 314 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 381
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 382 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 450
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493111 451 NLNVHRRIHTGEKPYECLVCGKAFSD 476
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-399 3.61e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 3.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 240 PYECHDCGKAFQHPSHLKEHVR--NHTGE--KPYACT--QCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSFGDLVS 311
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 312 RRKHMRTHIVKKPVECRQ-------CGKTFRNQSILKTHMNSHTGEKPYGCD--LCGKAFSASSNLTAHRKIHTQERRYE 382
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 967493111 383 CAACGKVFGDYLSRRRH 399
Cdd:COG5048  449 CSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-489 4.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 239 RPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKA---FRWKSNFNLHKKNHMVEKTYECKECGKSFGDLVSR--- 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSsls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 313 -------------------------RKHMRTHIVKKPVECRQCGKTFRN----------------------QSILKTHMN 345
Cdd:COG5048  112 ssssnsndnnllsshslppssrdpqLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 346 SHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACGKVFGDYLSRRRHMSI------HLVKKRVECRQCGKAFR 419
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967493111 420 NQSTLKTHMRSHTG-EKPYECDHCGKAFSIGSNLNVHRR--IHTGE--KPYEC--LVCGKAFSDHSSLRSHVKTHRG 489
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-467 5.31e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 155 KPYECSDCGKAFNDPSALRSHARTHLKEKPFDCSQ--CGNAFRTLSALKIHMRVHTGERPYKC-DQCGKAYGRSCHLIAH 231
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 232 KRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLHKKNHMVEKTyeckecGKSFGDLVS 311
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 312 RRKHMRTHIVKKPVECRQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACGKVFG 391
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 392 DYLSRRRHMSIHL--VKKRVE-----CRQCGKAFRNQSTLKTHMRS--HTGE--KPYECDH--CGKAFSIGSNLNVHRRI 458
Cdd:COG5048  266 PTASSQSSSPNESdsSSEKGFslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ....*....
gi 967493111 459 HTGEKPYEC 467
Cdd:COG5048  346 HTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
72-198 1.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111  72 STEYAHLLEVFGMGPHLTQPMGRHAGKRPYHR------RDYGVAFKGRPHltQHVSMYDGRKM---HEC--HQCQKAFTT 140
Cdd:COG5048  323 SCPYSLCGKLFSRNDALKRHILLHTSISPAKEkllnssSKFSPLLNNEPP--QSLQQYKDLKNdkkSETlsNSCIRNFKR 400

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 141 SASLTRHRRIHTGEKPYEC--SDCGKAFNDPSALRSHARTHLKEKPFDCSQCGNAFRTLS 198
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-447 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....
gi 967493111  424 LKTHMRSHTGEKPYECDHCGKAFS 447
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-339 1.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 155 KPYECSDCGKAFNDPSALRSHARTHLKE----KPFDC--SQCGNAFRTLSALKIHMRVHTGERPYKcdqcgkaygrsCHL 228
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK-----------EKL 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 229 IAHKRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGekpyactqCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSF 306
Cdd:COG5048  357 LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        170       180       190
                 ....*....|....*....|....*....|...
gi 967493111 307 GDLVSRRKHMRTHIVKKPVECRQCGKTFRNQSI 339
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
420-496 2.47e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493111 420 NQSTLKTHMRSHTGE----KPYECDHCGKAFSIGSNLNVHRRIHTGEKPYECLV--CGKAFSDHSSLRSHVKTHRGEKLF 493
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92


                 ...
gi 967493111 494 VSS 496
Cdd:COG5048   93 LNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-278 5.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.50e-04
                          10        20
                  ....*....|....*....|....
gi 967493111  255 HLKEHVRNHTGEKPYACTQCGKAF 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-167 8.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.89e-04
                          10        20
                  ....*....|....*....|....*
gi 967493111  143 SLTRHRRIHTGEKPYECSDCGKAFN 167
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 155-207 1.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967493111 155 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 207
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 414-485 1.51e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967493111 414 CGKAFRNQSTLKTHMRShtgekpyecDHCGKAFSIGSNLNVHRRIHTGEKPYECLVCGKAFSDHSSLRSHVK 485
Cdd:COG5189  357 CNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-222 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....
gi 967493111  199 ALKIHMRVHTGERPYKCDQCGKAY 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-475 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*
gi 967493111  451 NLNVHRRIHTGEKPYECLVCGKAFS 475
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
227-250 5.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....
gi 967493111  227 HLIAHKRTHTGERPYECHDCGKAF 250
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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