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Conserved domains on  [gi|967493062|ref|XP_014978254|]
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zinc finger protein 317 isoform X1 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
57-109 1.04e-26

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.67  E-value: 1.04e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 967493062    57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLGYQVGKPSLISHL 109
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQL 53
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-569 6.82e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 222 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 275
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 276 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 327
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 328 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 406
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 407 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 474
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 475 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 543
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493062 544 NLNVHRRIHTGEKPYECLVCGKAFSD 569
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
57-109 1.04e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.67  E-value: 1.04e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 967493062    57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLGYQVGKPSLISHL 109
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQL 53
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 1.09e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.69  E-value: 1.09e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967493062   56 SVTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLG 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-96 1.34e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.34e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 967493062  57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSL 96
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-569 6.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 222 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 275
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 276 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 327
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 328 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 406
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 407 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 474
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 475 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 543
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493062 544 NLNVHRRIHTGEKPYECLVCGKAFSD 569
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-540 5.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.64e-05
                          10        20
                  ....*....|....*....|....
gi 967493062  517 LKTHMRSHTGEKPYECDHCGKAFS 540
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 248-300 5.83e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967493062 248 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 300
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
57-109 1.04e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 102.67  E-value: 1.04e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 967493062    57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLGYQVGKPSLISHL 109
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQL 53
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 56-97 1.09e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 93.69  E-value: 1.09e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 967493062   56 SVTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSLG 97
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 57-96 1.34e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.34e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 967493062  57 VTFQDVAVDFTEKEWPLLDSSQRKLYKDVMLENYSNLTSL 96
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-569 6.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 222 HECHQCQKAFTTSASLTRHRRIHTGEKPYECSD--CGKAFNDPSALRSHARTHLKE------------------------ 275
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskasssslsss 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 276 -----KPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQC-----------------------GKAYGRSCHLIAHKRT 327
Cdd:COG5048  114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 328 HTGERPYECHDCGKaFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLH-KKNHMVEKTYECKECGKSFGDLVSRR 406
Cdd:COG5048  194 TSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 407 KH-----MRTHIVK-KPVECRQCGKTFRNQSILKTHMNS--HTGE--KPYGCD--LCGKAFSASSNLTAHRKIHTQERRY 474
Cdd:COG5048  273 SSpnesdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 475 ECAAC-------GKVFGDYLSRRRHMSIHLVKKRVEC--RQCGKAFRNQSTLKTHMRSHTGEKPYECD--HCGKAFSIGS 543
Cdd:COG5048  353 KEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420
                 ....*....|....*....|....*.
gi 967493062 544 NLNVHRRIHTGEKPYECLVCGKAFSD 569
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-492 2.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 333 PYECHDCGKAFQHPSHLKEHVR--NHTGE--KPYACT--QCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSFGDLVS 404
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 405 RRKHMRTHIVKKPVECRQ-------CGKTFRNQSILKTHMNSHTGEKPYGCD--LCGKAFSASSNLTAHRKIHTQERRYE 475
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 967493062 476 CAACGKVFGDYLSRRRH 492
Cdd:COG5048  449 CSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-560 2.99e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 248 KPYECSDCGKAFNDPSALRSHARTHLKEKPFDCSQ--CGNAFRTLSALKIHMRVHTGERPYKC-DQCGKAYGRSCHLIAH 324
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 325 KRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKAFRWKSNFNLHKKNHMVEKTyeckecGKSFGDLVS 404
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 405 RRKHMRTHIVKKPVECRQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACGKVFG 484
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 485 DYLSRRRHMSIHL--VKKRVE-----CRQCGKAFRNQSTLKTHMRS--HTGE--KPYECDH--CGKAFSIGSNLNVHRRI 551
Cdd:COG5048  266 PTASSQSSSPNESdsSSEKGFslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ....*....
gi 967493062 552 HTGEKPYEC 560
Cdd:COG5048  346 HTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
332-582 3.71e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 332 RPYECHDCGKAFQHPSHLKEHVRNHTGEKPYACTQCGKA---FRWKSNFNLHKKNHMVEKTYECKECGKSFGDLVSR--- 405
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSsls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 406 -------------------------RKHMRTHIVKKPVECRQCGKTFRN----------------------QSILKTHMN 438
Cdd:COG5048  112 ssssnsndnnllsshslppssrdpqLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 439 SHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRYECAACGKVFGDYLSRRRHMSI------HLVKKRVECRQCGKAFR 512
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967493062 513 NQSTLKTHMRSHTG-EKPYECDHCGKAFSIGSNLNVHRR--IHTGE--KPYEC--LVCGKAFSDHSSLRSHVKTHRG 582
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-540 5.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.64e-05
                          10        20
                  ....*....|....*....|....
gi 967493062  517 LKTHMRSHTGEKPYECDHCGKAFS 540
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-371 2.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.25e-04
                          10        20
                  ....*....|....*....|....
gi 967493062  348 HLKEHVRNHTGEKPYACTQCGKAF 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-260 3.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|....*
gi 967493062  236 SLTRHRRIHTGEKPYECSDCGKAFN 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-291 5.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 5.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 165 STEYAHLLEVFGMGPHLTQPMGRHAGKRPYHR------RDYGVAFKGRPHltQHVSMYDGRKM---HEC--HQCQKAFTT 233
Cdd:COG5048  323 SCPYSLCGKLFSRNDALKRHILLHTSISPAKEkllnssSKFSPLLNNEPP--QSLQQYKDLKNdkkSETlsNSCIRNFKR 400

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 234 SASLTRHRRIHTGEKPYEC--SDCGKAFNDPSALRSHARTHLKEKPFDCSQCGNAFRTLS 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 248-300 5.83e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 967493062 248 KPYeCSDCGKAFNDPSALRSHarthLKEKPFDCSQCGNAFRTLSALKIH-MRVH 300
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-315 6.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.56e-04
                          10        20
                  ....*....|....*....|....
gi 967493062  292 ALKIHMRVHTGERPYKCDQCGKAY 315
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
513-589 7.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 513 NQSTLKTHMRSHTGE----KPYECDHCGKAFSIGSNLNVHRRIHTGEKPYECLV--CGKAFSDHSSLRSHVKTHRGEKLF 586
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92


                 ...
gi 967493062 587 VSS 589
Cdd:COG5048   93 LNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
248-432 7.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 248 KPYECSDCGKAFNDPSALRSHARTHLKE----KPFDC--SQCGNAFRTLSALKIHMRVHTGERPYKcdqcgkaygrsCHL 321
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK-----------EKL 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967493062 322 IAHKRTHTGERPYECHDCGKAFQHPSHLKEHVRNHTGekpyactqCGKAFRWKSNFNLHKKNHMVEKTYECK--ECGKSF 399
Cdd:COG5048  357 LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        170       180       190
                 ....*....|....*....|....*....|...
gi 967493062 400 GDLVSRRKHMRTHIVKKPVECRQCGKTFRNQSI 432
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-568 8.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.22e-04
                          10        20
                  ....*....|....*....|....*
gi 967493062  544 NLNVHRRIHTGEKPYECLVCGKAFS 568
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 507-578 2.02e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 967493062 507 CGKAFRNQSTLKTHMRShtgekpyecDHCGKAFSIGSNLNVHRRIHTGEKPYECLVCGKAFSDHSSLRSHVK 578
Cdd:COG5189  357 CNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-343 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....
gi 967493062  320 HLIAHKRTHTGERPYECHDCGKAF 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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