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Conserved domains on  [gi|1622885923|ref|XP_014976445|]
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proline and serine-rich protein 1 isoform X2 [Macaca mulatta]

Protein Classification

DUF4476 domain-containing protein( domain architecture ID 10632145)

DUF4476 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4476 pfam14771
Domain of unknown function (DUF4476);
29-121 4.32e-19

Domain of unknown function (DUF4476);


:

Pssm-ID: 434196  Cd Length: 91  Bit Score: 82.62  E-value: 4.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  29 VHGYFSSEQVVDLLRYFSWAEPQLKAMKA--LQHKMVAVQpteVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDL 106
Cdd:pfam14771   1 VMSDNDFDQLVEKLKRFSFDDDKLKLLEQalLNNYFTCSQ---AAQLLKIFSFDDDRLKALKLLYPNIVDKQNYEVIIDV 77

                          90
                  ....*....|....*
gi 1622885923 107 FRINmSEKKRCKRIL 121
Cdd:pfam14771  78 FTFS-SDKDKAREIL 91
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 146-585 3.44e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 3.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  146 PYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPippcRPHATIAPSAYNHAGLVPL 225
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP----SPAANEPDPHPPPTVPPPE 2650

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  226 ASVIAPEnedLSNQSKPIQNQTFSTPASQLFSPHGsnPSTPAATpvPTASPVKAINHPSASAAATVSGMNLPNTVLPVFP 305
Cdd:PHA03247  2651 RPRDDPA---PGRVSRPRRARRLGRAAQASSPPQR--PRRRAAR--PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  306 GQVSSAVHTPQPstpnPTVIRTPSLPTAPVTSIhSTTTTPVPSIFSGLVSlPGPSATPTPGPTPRSTLGSSETfASTSAP 385
Cdd:PHA03247  2724 GPAAARQASPAL----PAAPAPPAVPAGPATPG-GPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVAS-LSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  386 FTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTP--------VIAGGSTPsvAGPLGVNSPLLSALKG 457
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPpgppppslPLGGSVAP--GGDVRRRPPSRSPAAK 2874

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  458 FLTSSDTSLISSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTS---TPGLALFPGLPSPVANSTST 534
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPpppPPPRPQPPLAPTTDPAGAGE 2954

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622885923  535 PLTLPVQSPLATVASASTSAP-VSCGSSAPLLHGPHPGTSDLHISSTPAVTT 585
Cdd:PHA03247  2955 PSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 495-922 2.82e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  495 ASAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSplatvasASTSAPVSCGSSAPLLHGPHPGTSD 574
Cdd:PHA03247  2548 AGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQS-------ARPRAPVDDRGDPRGPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  575 LHISSTPAVTTLPVmiKTEPTSPTPSAFKGPSHSGN-PSHGTLGLS---GTLGRAYTSTSVPISLSTCLNPALSGlssls 650
Cdd:PHA03247  2621 THAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDdPAPGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVG----- 2693

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  651 thlngsnTLSSISLPPHGSSTPIAPVFTALPPFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAV 730
Cdd:PHA03247  2694 -------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  731 LSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATV 810
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  811 PSPAP----VLPG--FASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFSQNPSQSslqelqhnAAAQSAL 884
Cdd:PHA03247  2847 PPSLPlggsVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP--------QAPPPPQ 2918

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1622885923  885 LQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLS 922
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
 
Name Accession Description Interval E-value
DUF4476 pfam14771
Domain of unknown function (DUF4476);
29-121 4.32e-19

Domain of unknown function (DUF4476);


Pssm-ID: 434196  Cd Length: 91  Bit Score: 82.62  E-value: 4.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  29 VHGYFSSEQVVDLLRYFSWAEPQLKAMKA--LQHKMVAVQpteVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDL 106
Cdd:pfam14771   1 VMSDNDFDQLVEKLKRFSFDDDKLKLLEQalLNNYFTCSQ---AAQLLKIFSFDDDRLKALKLLYPNIVDKQNYEVIIDV 77

                          90
                  ....*....|....*
gi 1622885923 107 FRINmSEKKRCKRIL 121
Cdd:pfam14771  78 FTFS-SDKDKAREIL 91
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-585 3.44e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 3.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  146 PYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPippcRPHATIAPSAYNHAGLVPL 225
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP----SPAANEPDPHPPPTVPPPE 2650

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  226 ASVIAPEnedLSNQSKPIQNQTFSTPASQLFSPHGsnPSTPAATpvPTASPVKAINHPSASAAATVSGMNLPNTVLPVFP 305
Cdd:PHA03247  2651 RPRDDPA---PGRVSRPRRARRLGRAAQASSPPQR--PRRRAAR--PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  306 GQVSSAVHTPQPstpnPTVIRTPSLPTAPVTSIhSTTTTPVPSIFSGLVSlPGPSATPTPGPTPRSTLGSSETfASTSAP 385
Cdd:PHA03247  2724 GPAAARQASPAL----PAAPAPPAVPAGPATPG-GPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVAS-LSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  386 FTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTP--------VIAGGSTPsvAGPLGVNSPLLSALKG 457
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPpgppppslPLGGSVAP--GGDVRRRPPSRSPAAK 2874

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  458 FLTSSDTSLISSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTS---TPGLALFPGLPSPVANSTST 534
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPpppPPPRPQPPLAPTTDPAGAGE 2954

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622885923  535 PLTLPVQSPLATVASASTSAP-VSCGSSAPLLHGPHPGTSDLHISSTPAVTT 585
Cdd:PHA03247  2955 PSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
213-410 4.49e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.05  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 213 APSAYNHAGLVPLASVIAPENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVS 292
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 293 GMNLPNTVLPVFPGQVSSAVHTPQPSTPNPTVIRTPSLPTAPVTSIHSTT-----TTPVPSIFSGLVSLPGPSATPTPGP 367
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATssagsTTTTTTVSGTETATGGTTTTSTTTT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1622885923 368 TPRSTLGSSETFASTSAPFTSLPFSISSTAASTSNPNSASLSS 410
Cdd:COG3469   172 TTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
PHA03247 PHA03247
large tegument protein UL36; Provisional
 495-922 2.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  495 ASAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSplatvasASTSAPVSCGSSAPLLHGPHPGTSD 574
Cdd:PHA03247  2548 AGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQS-------ARPRAPVDDRGDPRGPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  575 LHISSTPAVTTLPVmiKTEPTSPTPSAFKGPSHSGN-PSHGTLGLS---GTLGRAYTSTSVPISLSTCLNPALSGlssls 650
Cdd:PHA03247  2621 THAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDdPAPGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVG----- 2693

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  651 thlngsnTLSSISLPPHGSSTPIAPVFTALPPFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAV 730
Cdd:PHA03247  2694 -------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  731 LSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATV 810
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  811 PSPAP----VLPG--FASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFSQNPSQSslqelqhnAAAQSAL 884
Cdd:PHA03247  2847 PPSLPlggsVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP--------QAPPPPQ 2918

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1622885923  885 LQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLS 922
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 232-612 4.06e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 232 ENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVkainhpSASAAATVSGMNLPNTVLPVFPGQVSSA 311
Cdd:pfam03154 153 DNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAG------PTPSAPSVPPQGSPATSQPPNQTQSTAA 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 312 VHTPQPSTPNPTVIRTPS-------LPTAPVTSIHSTTTTPVPSIFSGLVSLP-----GPSATPTPGPtPRSTLGSSETF 379
Cdd:pfam03154 227 PHTLIQQTPTLHPQRLPSphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPPMPhslqtGPSHMQHPVP-PQPFPLTPQSS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 380 ASTSAPFTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGPLGVNSPLLSALKGFl 459
Cdd:pfam03154 306 QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPF- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 460 tssdtslisSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVAN--STSTPLT 537
Cdd:pfam03154 385 ---------QMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAAShpPTSGLHQ 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 538 LPVQSPLAT---------VASASTSAPVSCGSSAPLLHGPH--PGTSDLHISSTPAVTTLPVMIKTEPTSPTPSAFKGPS 606
Cdd:pfam03154 456 VPSQSPFPQhpfvpggppPITPPSGPPTSTSSAMPGIQPPSsaSVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPP 535


                  ....*.
gi 1622885923 607 HSGNPS 612
Cdd:pfam03154 536 PPRSPS 541
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 490-815 1.31e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 490 NSDSSA------SAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLAtVASASTSAPVSCGSSAP 563
Cdd:pfam03154 157 DSDSSAqqqilqTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPP-NQTQSTAAPHTLIQQTP 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 564 LLH-----GPHPGTSDLHISSTPAVTT---LPVMIKTEPTSPTPSAFK-GPSHSGNPShgtlglsGTLGRAYTSTSVPIS 634
Cdd:pfam03154 236 TLHpqrlpSPHPPLQPMTQPPPPSQVSpqpLPQPSLHGQMPPMPHSLQtGPSHMQHPV-------PPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 635 LSTCLNPALSGLSSLSTHLNGSNTLSSISLPPHGSSTPIAPVFTA--LPPFTSLTNNFPLTGNPSLNPSVSLPGSLiats 712
Cdd:pfam03154 309 VPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhiKPPPTTPIPQLPNPQSHKHPPHLSGPSPF---- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 713 staATSTSLPHPSSTAAvLSGLSASAPVSAAPFPLNL--------------------------STAVPSLFSVTQGPLSS 766
Cdd:pfam03154 385 ---QMNSNLPPPPALKP-LSSLSTHHPPSAHPPPLQLmpqsqqlppppaqppvltqsqslpppAASHPPTSGLHQVPSQS 460

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622885923 767 SNPSYPgFSVSNTPSVTPAL-------PSFPGLQAPSTVAAVTPLPVAATVPSPAP 815
Cdd:pfam03154 461 PFPQHP-FVPGGPPPITPPSgpptstsSAMPGIQPPSSASVSSSGPVPAAVSCPLP 515
 
Name Accession Description Interval E-value
DUF4476 pfam14771
Domain of unknown function (DUF4476);
29-121 4.32e-19

Domain of unknown function (DUF4476);


Pssm-ID: 434196  Cd Length: 91  Bit Score: 82.62  E-value: 4.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  29 VHGYFSSEQVVDLLRYFSWAEPQLKAMKA--LQHKMVAVQpteVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDL 106
Cdd:pfam14771   1 VMSDNDFDQLVEKLKRFSFDDDKLKLLEQalLNNYFTCSQ---AAQLLKIFSFDDDRLKALKLLYPNIVDKQNYEVIIDV 77

                          90
                  ....*....|....*
gi 1622885923 107 FRINmSEKKRCKRIL 121
Cdd:pfam14771  78 FTFS-SDKDKAREIL 91
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-585 3.44e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 3.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  146 PYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPippcRPHATIAPSAYNHAGLVPL 225
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP----SPAANEPDPHPPPTVPPPE 2650

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  226 ASVIAPEnedLSNQSKPIQNQTFSTPASQLFSPHGsnPSTPAATpvPTASPVKAINHPSASAAATVSGMNLPNTVLPVFP 305
Cdd:PHA03247  2651 RPRDDPA---PGRVSRPRRARRLGRAAQASSPPQR--PRRRAAR--PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  306 GQVSSAVHTPQPstpnPTVIRTPSLPTAPVTSIhSTTTTPVPSIFSGLVSlPGPSATPTPGPTPRSTLGSSETfASTSAP 385
Cdd:PHA03247  2724 GPAAARQASPAL----PAAPAPPAVPAGPATPG-GPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVAS-LSESRE 2796

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  386 FTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTP--------VIAGGSTPsvAGPLGVNSPLLSALKG 457
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPpgppppslPLGGSVAP--GGDVRRRPPSRSPAAK 2874

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  458 FLTSSDTSLISSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTS---TPGLALFPGLPSPVANSTST 534
Cdd:PHA03247  2875 PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPpppPPPRPQPPLAPTTDPAGAGE 2954

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622885923  535 PLTLPVQSPLATVASASTSAP-VSCGSSAPLLHGPHPGTSDLHISSTPAVTT 585
Cdd:PHA03247  2955 PSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-783 1.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  258 PHGSNPSTPAATPVPTASP---VKAINHPSASAAATVSGMNLPNTVLPVFPGQVSSAVHTPQPSTPNPTVIRTPSL-PTA 333
Cdd:PHA03247  2484 AEARFPFAAGAAPDPGGGGppdPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAApPAA 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  334 PVTSIHSTTTTPVPSIFSGLVSLPGPSATPTPGpTPRSTLGSSETFASTSAPfTSLPFSISSTAASTSNPNSASlSSVFA 413
Cdd:PHA03247  2564 PDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSA-RPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSPAA-NEPDP 2640

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  414 GLPLPLPPTSQGLSNPTP---------VIAGGSTPSVAGPLGVNSPLLSALKGFLTSSDTSLISSSALSSAVTSgLASLS 484
Cdd:PHA03247  2641 HPPPTVPPPERPRDDPAPgrvsrprraRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHA-LVSAT 2719

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  485 SLTLQNSDSSASAPSKCYAPSAIPPPQRTSTPGLALFPGLP-SPVANSTSTPLTLPVQSP--LATVASASTSAPVSCGSS 561
Cdd:PHA03247  2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPpTTAGPPAPAPPAAPAAGPprRLTRPAVASLSESRESLP 2799

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  562 APLLHGPHPG-----TSDLHISSTPAvTTLPVMIKTEPTSPTPSafKGPSHSGNPSHGTLGLSGTLGRAYTSTSVPISLS 636
Cdd:PHA03247  2800 SPWDPADPPAavlapAAALPPAASPA-GPLPPPTSAQPTAPPPP--PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  637 TCLNPALSGLSSLSThlngSNTLSSISLPPHGSSTPIAPVfTALPPFTSLTNNFPLTGNPSLNPSvslpgsliatsstaa 716
Cdd:PHA03247  2877 APARPPVRRLARPAV----SRSTESFALPPDQPERPPQPQ-APPPPQPQPQPPPPPQPQPPPPPP--------------- 2936

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622885923  717 tstslPHPSSTAAVLSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGfSVSNTPSVT 783
Cdd:PHA03247  2937 -----PRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-PASSTPPLT 2997
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
213-410 4.49e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 47.05  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 213 APSAYNHAGLVPLASVIAPENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVS 292
Cdd:COG3469    12 AGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 293 GMNLPNTVLPVFPGQVSSAVHTPQPSTPNPTVIRTPSLPTAPVTSIHSTT-----TTPVPSIFSGLVSLPGPSATPTPGP 367
Cdd:COG3469    92 TSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATssagsTTTTTTVSGTETATGGTTTTSTTTT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1622885923 368 TPRSTLGSSETFASTSAPFTSLPFSISSTAASTSNPNSASLSS 410
Cdd:COG3469   172 TTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
PHA03247 PHA03247
large tegument protein UL36; Provisional
 495-922 2.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  495 ASAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSplatvasASTSAPVSCGSSAPLLHGPHPGTSD 574
Cdd:PHA03247  2548 AGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQS-------ARPRAPVDDRGDPRGPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  575 LHISSTPAVTTLPVmiKTEPTSPTPSAFKGPSHSGN-PSHGTLGLS---GTLGRAYTSTSVPISLSTCLNPALSGlssls 650
Cdd:PHA03247  2621 THAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDdPAPGRVSRPrraRRLGRAAQASSPPQRPRRRAARPTVG----- 2693

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  651 thlngsnTLSSISLPPHGSSTPIAPVFTALPPFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAV 730
Cdd:PHA03247  2694 -------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  731 LSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATV 810
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  811 PSPAP----VLPG--FASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFSQNPSQSslqelqhnAAAQSAL 884
Cdd:PHA03247  2847 PPSLPlggsVAPGgdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP--------QAPPPPQ 2918

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1622885923  885 LQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLS 922
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 232-612 4.06e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 232 ENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVkainhpSASAAATVSGMNLPNTVLPVFPGQVSSA 311
Cdd:pfam03154 153 DNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAG------PTPSAPSVPPQGSPATSQPPNQTQSTAA 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 312 VHTPQPSTPNPTVIRTPS-------LPTAPVTSIHSTTTTPVPSIFSGLVSLP-----GPSATPTPGPtPRSTLGSSETF 379
Cdd:pfam03154 227 PHTLIQQTPTLHPQRLPSphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPPMPhslqtGPSHMQHPVP-PQPFPLTPQSS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 380 ASTSAPFTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGPLGVNSPLLSALKGFl 459
Cdd:pfam03154 306 QSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPF- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 460 tssdtslisSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVAN--STSTPLT 537
Cdd:pfam03154 385 ---------QMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAAShpPTSGLHQ 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 538 LPVQSPLAT---------VASASTSAPVSCGSSAPLLHGPH--PGTSDLHISSTPAVTTLPVMIKTEPTSPTPSAFKGPS 606
Cdd:pfam03154 456 VPSQSPFPQhpfvpggppPITPPSGPPTSTSSAMPGIQPPSsaSVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPP 535


                  ....*.
gi 1622885923 607 HSGNPS 612
Cdd:pfam03154 536 PPRSPS 541
PHA03247 PHA03247
large tegument protein UL36; Provisional
 143-519 4.49e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  143 PGNPYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPP--------CRPHATIAP 214
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPtvgsltslADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  215 SAYNHAGLVPlaSVIAPENEDLSNQSKPiqnqtfSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVSGm 294
Cdd:PHA03247  2708 PEPAPHALVS--ATPLPPGPAAARQASP------ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG- 2778

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  295 nlPNTVLPVFPGQVSSAVHTPQPSTPNPTVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTPGPTPR---- 370
Cdd:PHA03247  2779 --PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsv 2856

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923  371 ------STLGSSETFASTSAPFTSLPFSISSTAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGP 444
Cdd:PHA03247  2857 apggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622885923  445 LGVNSPLLSalkgflTSSDTSLISSSALSSAVTSGLASLSSLTLQNSDSSASAPSKCYAPSAIPPPQRTSTPGLA 519
Cdd:PHA03247  2937 PRPQPPLAP------TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 185-516 6.11e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 6.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 185 PSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYNHAGLVPLASviaPENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPS 264
Cdd:pfam03154 204 PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH---PPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPH 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 265 TPAATPVPTASPVKAINHPSASAAATVSGMNLPNTVLPvfpGQVSSAVHTP--QPSTPNPTVIRTPSLPTAPVTSIH--S 340
Cdd:pfam03154 281 SLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAP---GQSQQRIHTPpsQSQLQSQQPPREQPLPPAPLSMPHikP 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 341 TTTTPVPSIFSGL-------VSLPGP-----SATPTPGPTPRSTLGSSETFASTSAPFTSLPFSISSTAASTSNP---NS 405
Cdd:pfam03154 358 PPTTPIPQLPNPQshkhpphLSGPSPfqmnsNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvltQS 437

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 406 ASLSSVFAGLPLPL---PPTSQGLSNPTPVIAGGStPSVAGPLGVNSPLLSALKGfltssdtsLISSSALSSAVTSGLAS 482
Cdd:pfam03154 438 QSLPPPAASHPPTSglhQVPSQSPFPQHPFVPGGP-PPITPPSGPPTSTSSAMPG--------IQPPSSASVSSSGPVPA 508

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1622885923 483 LSSLTLQNSDSSASAPSKCYAPSAIPPPQRTSTP 516
Cdd:pfam03154 509 AVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSP 542
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 490-815 1.31e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 490 NSDSSA------SAPSKCYAPSAIPPPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLAtVASASTSAPVSCGSSAP 563
Cdd:pfam03154 157 DSDSSAqqqilqTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPP-NQTQSTAAPHTLIQQTP 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 564 LLH-----GPHPGTSDLHISSTPAVTT---LPVMIKTEPTSPTPSAFK-GPSHSGNPShgtlglsGTLGRAYTSTSVPIS 634
Cdd:pfam03154 236 TLHpqrlpSPHPPLQPMTQPPPPSQVSpqpLPQPSLHGQMPPMPHSLQtGPSHMQHPV-------PPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 635 LSTCLNPALSGLSSLSTHLNGSNTLSSISLPPHGSSTPIAPVFTA--LPPFTSLTNNFPLTGNPSLNPSVSLPGSLiats 712
Cdd:pfam03154 309 VPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhiKPPPTTPIPQLPNPQSHKHPPHLSGPSPF---- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 713 staATSTSLPHPSSTAAvLSGLSASAPVSAAPFPLNL--------------------------STAVPSLFSVTQGPLSS 766
Cdd:pfam03154 385 ---QMNSNLPPPPALKP-LSSLSTHHPPSAHPPPLQLmpqsqqlppppaqppvltqsqslpppAASHPPTSGLHQVPSQS 460

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622885923 767 SNPSYPgFSVSNTPSVTPAL-------PSFPGLQAPSTVAAVTPLPVAATVPSPAP 815
Cdd:pfam03154 461 PFPQHP-FVPGGPPPITPPSgpptstsSAMPGIQPPSSASVSSSGPVPAAVSCPLP 515
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 257-385 4.74e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 257 SPHGSNPSTPAATPVPTA-SPVKAINHPSASAAATVSGMNLPntvlpvfpgqvSSAVHTPQPSTPNPT-VIRTP----SL 330
Cdd:pfam05109 503 APDMTSPTSAVTTPTPNAtSPTPAVTTPTPNATSPTLGKTSP-----------TSAVTTPTPNATSPTpAVTTPtpnaTI 571

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622885923 331 PTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATptpgpTPRSTLGSSETFASTSAP 385
Cdd:pfam05109 572 PTLGKTSPTSAVTTPTPNATSPTVGETSPQAN-----TTNHTLGGTSSTPVVTSP 621
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 226-383 5.07e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 226 ASVIAPENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVSgmnLPNTVLPvfp 305
Cdd:pfam05109 450 SSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTP---TPNATSP--- 523

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622885923 306 gqvSSAVHTPQPSTPNPTVIRTPslPTAPVTSIHSTTTTPVPSifsglVSLPGPSAT-PTPGPTPRSTLGSSETFASTS 383
Cdd:pfam05109 524 ---TPAVTTPTPNATSPTLGKTS--PTSAVTTPTPNATSPTPA-----VTTPTPNATiPTLGKTSPTSAVTTPTPNATS 592
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
231-372 6.37e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.03  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 231 PENEDLSNQSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVK-AINHPSASAAATVSGMNLPNTVLPVFPGQVS 309
Cdd:pfam05539 179 SWPTEVSHPTYPSQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTsSNPEPQTEPPPSQRGPSGSPQHPPSTTSQDQ 258

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622885923 310 SAVHTPQPSTPNPtviRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTPGPTPRST 372
Cdd:pfam05539 259 STTGDGQEHTQRR---KTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPPHS 318
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 241-374 6.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 241 KPiQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAinhPSASAAATVSGMNLPNTVLPVFPGQVSSAVHTPQPSTP 320
Cdd:PRK14951  365 KP-AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPA---PAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622885923 321 NPTVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTPGPTPRSTLG 374
Cdd:PRK14951  441 APAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 184-328 6.67e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 184 GPSKPPPSTYNPHKPV---PYPIPPCRPHATIAPSAynhaglVPLASVIAPenedlsnqskpiqnqtfSTPASQLFSPHG 260
Cdd:PRK14951  370 AEAAAPAEKKTPARPEaaaPAAAPVAQAAAAPAPAA------APAAAASAP-----------------AAPPAAAPPAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622885923 261 SNPSTPAATPVPTASPVKAINHPSASAAATVSGMNLPNTVLPVFPGQVSSAVHTPQPstPNPTVIRTP 328
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAP--AAARLTPTE 492
PRK11901 PRK11901
hypothetical protein; Reviewed
 233-376 8.06e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 39.28  E-value: 8.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 233 NEDLSNQS-KPIQNQTFSTPASQLFSPHGSNPSTPAATP----VPTASPVKAINHPSASAA------------------- 288
Cdd:PRK11901   78 NIDLSGSSsLSSGNQSSPSAANNTSDGHDASGVKNTAPPqdisAPPISPTPTQAAPPQTPNgqqrielpgnisdalsqqq 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622885923 289 ----ATVSGMNLPNTVLPVFPGQVSSAVHTPQPSTPNPTVIRTPSLPTA-PVTSIHSTTTTPVPsifsglvslPGPSATP 363
Cdd:PRK11901  158 gqvnAASQNAQGNTSTLPTAPATVAPSKGAKVPATAETHPTPPQKPATKkPAVNHHKTATVAVP---------PATSGKP 228

                         170
                  ....*....|...
gi 1622885923 364 TPGPTPRSTLGSS 376
Cdd:PRK11901  229 KSGAASARALSSA 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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