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Conserved domains on  [gi|967250276|ref|XP_014976102|]
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COP9 signalosome complex subunit 1 isoform X2 [Macaca mulatta]

Protein Classification

COP9 signalosome complex subunit 1( domain architecture ID 10566214)

The COP9 signalosome subunit 1 (CSN1) is an essential component of the CSN complex and is involved in the deubiquitination of target proteins which helps to regulate the stability and activity of a variety of proteins involved in different cellular pathways

Gene Ontology:  GO:0000338|GO:0008180|GO:2000434
PubMed:  27029275|9644972
SCOP:  4000147

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
167-348 8.61e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.90  E-value: 8.61e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  167 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 246
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  247 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 326
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 967250276  327 NVAIYGGLCALATFDRQELQRN 348
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
363-467 9.12e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.05  E-value: 9.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  363 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 442
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 967250276  443 LTQLILEGLISARVDSHSKILYARD 467
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
167-348 8.61e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.90  E-value: 8.61e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  167 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 246
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  247 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 326
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 967250276  327 NVAIYGGLCALATFDRQELQRN 348
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
363-467 9.12e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.05  E-value: 9.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  363 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 442
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 967250276  443 LTQLILEGLISARVDSHSKILYARD 467
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
207-505 3.37e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 86.89  E-value: 3.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 207 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAERG---ERDSqt 281
Cdd:COG5187  120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGgdwERRN-- 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 282 qailtKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfL 359
Cdd:COG5187  193 -----RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---L 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 360 ELEPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAF 432
Cdd:COG5187  262 DVIGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTF 341
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967250276 433 NTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 505
Cdd:COG5187  342 GVSVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
399-482 6.24e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.05  E-value: 6.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276   399 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 474
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 967250276   475 FEKSLLMG 482
Cdd:smart00088  81 FAETLKKL 88
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
167-348 8.61e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 215.90  E-value: 8.61e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  167 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 246
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  247 KVSVYLQNWSHVLSYVSKAESTPEIAERGERdsqtqaiLTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSPS 326
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWER-------RNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISYE 152
                         170       180
                  ....*....|....*....|..
gi 967250276  327 NVAIYGGLCALATFDRQELQRN 348
Cdd:pfam10602 153 DVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
363-467 9.12e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.05  E-value: 9.12e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276  363 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 442
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 967250276  443 LTQLILEGLISARVDSHSKILYARD 467
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
207-505 3.37e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 86.89  E-value: 3.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 207 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAERG---ERDSqt 281
Cdd:COG5187  120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGgdwERRN-- 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 282 qailtKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfL 359
Cdd:COG5187  193 -----RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---L 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276 360 ELEPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAF 432
Cdd:COG5187  262 DVIGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTF 341
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967250276 433 NTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 505
Cdd:COG5187  342 GVSVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
399-482 6.24e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.05  E-value: 6.24e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967250276   399 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 474
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 967250276   475 FEKSLLMG 482
Cdd:smart00088  81 FAETLKKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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