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Conserved domains on  [gi|1622880766|ref|XP_014975644|]
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beta-2-glycoprotein 1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sushi_2 pfam09014
Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is ...
 261-345 1.66e-44

Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies.


:

Pssm-ID: 430371  Cd Length: 88  Bit Score: 147.44  E-value: 1.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 261 KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSL---AFWKT 337
Cdd:pfam09014   1 RAPCKIPVKRARVLYNGEKVWIQDLLKNGVLHGEIVSFFCKNKEKKCSYTVPAQCIDGTLKIPECFKEPTWLqykLFPKT 80


                  ....*...
gi 1622880766 338 DASDVKPC 345
Cdd:pfam09014  81 LPSEIKPC 88
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 25-260 3.17e-26

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 105.12  E-value: 3.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  25 KPDDLPF--SIVVPLKTFYEPGEEITYSCKPGY-VSRGGMRRFICPLTGMWPINtlKCTPRVCPFAGILENGAVRYTTFE 101
Cdd:PHA02927   26 RPINMKFknSVETDANANYNIGDTIEYLCLPGYrKQKMGPIYAKCTGTGWTLFN--QCIKRRCPSPRDIDNGQLDIGGVD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 102 YPNTINFSCNTGFYLNGANSAKC----TEEGQWSPGIPVCAPITCPPPsvPMFATLRvykpSAGNNSFYQDTAV--FECL 175
Cdd:PHA02927  104 FGSSITYSCNSGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSP--PSISNGR----HNGYEDFYTDGSVvtYSCN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 176 PQHAMFGNDTITCTThGNWTKLPECREVKCPFPlRPDNGFVNYPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS 255
Cdd:PHA02927  178 SGYSLIGNSGVLCSG-GEWSDPPTCQIVKCPHP-TISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQ 255


                  ....*.
gi 1622880766 256 A-MPSC 260
Cdd:PHA02927  256 PeLPKC 261
 
Name Accession Description Interval E-value
Sushi_2 pfam09014
Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is ...
 261-345 1.66e-44

Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies.


Pssm-ID: 430371  Cd Length: 88  Bit Score: 147.44  E-value: 1.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 261 KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSL---AFWKT 337
Cdd:pfam09014   1 RAPCKIPVKRARVLYNGEKVWIQDLLKNGVLHGEIVSFFCKNKEKKCSYTVPAQCIDGTLKIPECFKEPTWLqykLFPKT 80


                  ....*...
gi 1622880766 338 DASDVKPC 345
Cdd:pfam09014  81 LPSEIKPC 88
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 25-260 3.17e-26

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 105.12  E-value: 3.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  25 KPDDLPF--SIVVPLKTFYEPGEEITYSCKPGY-VSRGGMRRFICPLTGMWPINtlKCTPRVCPFAGILENGAVRYTTFE 101
Cdd:PHA02927   26 RPINMKFknSVETDANANYNIGDTIEYLCLPGYrKQKMGPIYAKCTGTGWTLFN--QCIKRRCPSPRDIDNGQLDIGGVD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 102 YPNTINFSCNTGFYLNGANSAKC----TEEGQWSPGIPVCAPITCPPPsvPMFATLRvykpSAGNNSFYQDTAV--FECL 175
Cdd:PHA02927  104 FGSSITYSCNSGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSP--PSISNGR----HNGYEDFYTDGSVvtYSCN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 176 PQHAMFGNDTITCTThGNWTKLPECREVKCPFPlRPDNGFVNYPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS 255
Cdd:PHA02927  178 SGYSLIGNSGVLCSG-GEWSDPPTCQIVKCPHP-TISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQ 255


                  ....*.
gi 1622880766 256 A-MPSC 260
Cdd:PHA02927  256 PeLPKC 261
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 84-137 7.31e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 7.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880766  84 CPFAGILENGAVRY--TTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:cd00033     1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 84-137 1.55e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880766   84 CPFAGILENGAVRY--TTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
142-200 3.82e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 3.82e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622880766 142 CPPPSVPMFAtlrvyKPSAGNNSF-YQDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PEC 200
Cdd:pfam00084   1 CPPPPDIPNG-----KVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPfPEC 56
 
Name Accession Description Interval E-value
Sushi_2 pfam09014
Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is ...
 261-345 1.66e-44

Beta-2-glycoprotein-1 fifth domain; The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies.


Pssm-ID: 430371  Cd Length: 88  Bit Score: 147.44  E-value: 1.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 261 KASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSL---AFWKT 337
Cdd:pfam09014   1 RAPCKIPVKRARVLYNGEKVWIQDLLKNGVLHGEIVSFFCKNKEKKCSYTVPAQCIDGTLKIPECFKEPTWLqykLFPKT 80


                  ....*...
gi 1622880766 338 DASDVKPC 345
Cdd:pfam09014  81 LPSEIKPC 88
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 25-260 3.17e-26

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 105.12  E-value: 3.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  25 KPDDLPF--SIVVPLKTFYEPGEEITYSCKPGY-VSRGGMRRFICPLTGMWPINtlKCTPRVCPFAGILENGAVRYTTFE 101
Cdd:PHA02927   26 RPINMKFknSVETDANANYNIGDTIEYLCLPGYrKQKMGPIYAKCTGTGWTLFN--QCIKRRCPSPRDIDNGQLDIGGVD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 102 YPNTINFSCNTGFYLNGANSAKC----TEEGQWSPGIPVCAPITCPPPsvPMFATLRvykpSAGNNSFYQDTAV--FECL 175
Cdd:PHA02927  104 FGSSITYSCNSGYQLIGESKSYCelgsTGSMVWNPEAPICESVKCQSP--PSISNGR----HNGYEDFYTDGSVvtYSCN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 176 PQHAMFGNDTITCTThGNWTKLPECREVKCPFPlRPDNGFVNYPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS 255
Cdd:PHA02927  178 SGYSLIGNSGVLCSG-GEWSDPPTCQIVKCPHP-TISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQ 255


                  ....*.
gi 1622880766 256 A-MPSC 260
Cdd:PHA02927  256 PeLPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 100-260 6.02e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 65.46  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 100 FEYPNTINFSCNTGFYLNGANSAKCTEEGQ---WSPGIPVCAPITC-PPPSV---PMFATLRVYKpsAGNNSFY---QDT 169
Cdd:PHA02639   40 YEIGKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCMLKECnDPPSIingKIYNKREMYK--VGDEIYYvcnEHK 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 170 AVfeclpQHAMFGNDTITCTTHGNWTKLPE-CREVKCPFPLRpDNGFVN-YPAKPVLYYKDKATFGCHDGYSLDGPEEIE 247
Cdd:PHA02639  118 GV-----QYSLVGNEKITCIQDKSWKPDPPiCKMINCRFPAL-QNGYINgIPSNKKFYYKTRVGFSCKSGFDLVGEKYST 191

                         170
                  ....*....|....
gi 1622880766 248 CTKLGNW-SAMPSC 260
Cdd:PHA02639  192 CNINATWfPSIPTC 205
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 84-137 7.31e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.09  E-value: 7.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880766  84 CPFAGILENGAVRY--TTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:cd00033     1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 84-137 1.55e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880766   84 CPFAGILENGAVRY--TTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 205-261 1.17e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 53.62  E-value: 1.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622880766 205 CPFPLRPDNGFVNYPaKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSCK 261
Cdd:cd00033     1 CPPPPVPENGTVTGS-KGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 205-260 2.87e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.53  E-value: 2.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622880766  205 CPFPLRPDNGFVNYPaKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSC 260
Cdd:smart00032   1 CPPPPDIENGTVTSS-SGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
142-200 3.82e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 3.82e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622880766 142 CPPPSVPMFAtlrvyKPSAGNNSF-YQDTAVFECLPQHAMFGNDTITCTTHGNWTKL-PEC 200
Cdd:pfam00084   1 CPPPPDIPNG-----KVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPfPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 178-298 8.99e-09

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 54.95  E-value: 8.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 178 HAMFGNDTITCTTHGNWTK-LPECREVKCPFPLRpDNGFVN-YPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWs 255
Cdd:PHA02817   61 YTLVGEKNIICEKDGKWNKeFPVCKIIRCRFPAL-QNGFVNgIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSW- 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1622880766 256 aMPSCKASCKVPVKKATVVYQgeRVKIQEKFKNGMLHGDKVSF 298
Cdd:PHA02817  139 -IPKVPICSRDNITYNKIYIN--KVNIDDNFFNQINNSNTYYF 178
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 23-137 3.87e-08

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 53.89  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  23 CPKPDDLPFSIVVPLKTFYEPGEEITYSCKPGYvSRGGMRRFICPlTGMWPiNTLKCTPRVCPFA----GILENGAVRyt 98
Cdd:PHA02927  148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGY-SLIGNSGVLCS-GGEWS-DPPTCQIVKCPHPtisnGYLSSGFKR-- 222

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622880766  99 TFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:PHA02927  223 SYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
84-137 6.84e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 48.65  E-value: 6.84e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880766  84 CPFAGILENGAVRYT--TFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:pfam00084   1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
205-260 1.09e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.88  E-value: 1.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622880766 205 CPFPLRPDNGFVnYPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKLGNWS-AMPSC 260
Cdd:pfam00084   1 CPPPPDIPNGKV-SATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSpPFPEC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 22-137 1.14e-07

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 52.78  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  22 TCPKPDDLPFSI----VVPLKTFYEPGEEITYSCKPGYVSRGGmrRFICPLTGMWpiNTLKCTPRVCPFAGiLENGAVRY 97
Cdd:PHA02954  124 TCPNAECQPLQLehgsCQPVKEKYSFGEHITINCDVGYEVIGA--SYISCTANSW--NVIPSCQQKCDIPS-LSNGLISG 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622880766  98 TTFEYPNTINFSCNTGFYLNGANSAKCTeEGQWSPGIPVC 137
Cdd:PHA02954  199 STFSIGGVIHLSCKSGFTLTGSPSSTCI-DGKWNPVLPIC 237
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 23-79 4.93e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.98  E-value: 4.93e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622880766   23 CPKPDDLPFSIVVPLKTFYEPGEEITYSCKPGYVSRGGMRRfICPLTGMWPINTLKC 79
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTI-TCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 23-79 5.32e-07

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 5.32e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622880766  23 CPKPDDLPFSIVVPLKTFYEPGEEITYSCKPGYVSRGGMRRfICPLTGMWPINTLKC 79
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 23-137 1.10e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 48.78  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  23 CPKPDDLPFSIVVPLKTFYEPGEEITYSCkpGYVSRG------GMRRFICPLTGMWPINTLKCTPRVCPFAGiLENGAVR 96
Cdd:PHA02817   24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFC--GNNTRGvrytlvGEKNIICEKDGKWNKEFPVCKIIRCRFPA-LQNGFVN 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622880766  97 ----YTTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:PHA02817  101 gipdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPIC 145
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 142-201 2.08e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 2.08e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622880766 142 CPPPSVPMFATLRVYKpsagNNSFYQDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPECR 201
Cdd:cd00033     1 CPPPPVPENGTVTGSK----GSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSpPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
23-72 3.79e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.64  E-value: 3.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622880766  23 CPKPDDLPFSIVVPLKTFYEPGEEITYSCKPGYVSRGGMRRFiCPLTGMW 72
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTIT-CQEDGTW 49
PHA02831 PHA02831
EEV host range protein; Provisional
 15-137 8.95e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 8.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  15 HVAIAGRTCPKPDDLPFSIVVPLKTFYEPGEEITYSCKPGYVSRG---GMRRFICpLTGMWPINTLKCTPRVCPFAGiLE 91
Cdd:PHA02831   70 NMCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACKVNKLEKYsivGNETVKC-INKQWVPKYPVCKLIRCKYPA-LQ 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622880766  92 NGAVRY--TTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:PHA02831  148 NGFLNVfeKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
PHA02831 PHA02831
EEV host range protein; Provisional
 99-260 1.02e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  99 TFEYPNTINFSCNTGFylngaNSAKCT-EEGQWSPGIPVCAPITCPPPsvpmFATLRVYKPSAGNNSFYQDTAVFEC--- 174
Cdd:PHA02831   39 VYEENENLEYKCNNNF-----DKVFVTcNNGSWSTKNMCIGKRNCKDP----VTILNGYIKNKKDQYSFGDSVTYACkvn 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 175 -LPQHAMFGNDTITCTtHGNWT-KLPECREVKCPFPLRpDNGFVNYPAKPvLYYKDKATFGCHDGYSLDGPEEIECTKLG 252
Cdd:PHA02831  110 kLEKYSIVGNETVKCI-NKQWVpKYPVCKLIRCKYPAL-QNGFLNVFEKK-FYYGDIVNFKCKKGFILLGSSVSTCDINS 186


                  ....*....
gi 1622880766 253 NW-SAMPSC 260
Cdd:PHA02831  187 IWyPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 21-137 1.53e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 46.20  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  21 RTCPKPDDLPFSIVVPLKTFYEPGEEITYSC---KPGYVSRGGMRRFICPLTGMWPINTLKCTPRVCPFAGILE---NGA 94
Cdd:PHA02639   83 KECNDPPSIINGKIYNKREMYKVGDEIYYVCnehKGVQYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNgyiNGI 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1622880766  95 VRYTTFEYPNTINFSCNTGFYLNGANSAKCTEEGQWSPGIPVC 137
Cdd:PHA02639  163 PSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTC 205
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 142-200 1.01e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.82  E-value: 1.01e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  142 CPPPSVPMFATLRVYKPsagnNSFYQDTAVFECLPQHAMFGNDTITCTTHGNWT-KLPEC 200
Cdd:smart00032   1 CPPPPDIENGTVTSSSG----TYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSpPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 98-267 1.80e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 42.77  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766  98 TTFEYPNTINFSCNTGFYLNGANSAkcTEEGQWSPGIPvCAPITCPPPSVPMFATLRVYKPSAGNNSFYQD-TAVFECLP 176
Cdd:PHA02954   36 TSFNDKQKVTFTCDSGYYSLDPNAV--CETDKWKYENP-CKKMCTVSDYVSELYDKPLYEVNSTITLICKDeTKYFRCEE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880766 177 QHAMFG-NDTITCTThgnwtklPECRevkcpfPLRPDNGFVNyPAKPVLYYKDKATFGCHDGYSLDGPEEIECTKlGNWS 255
Cdd:PHA02954  113 KNGNTSwNDTVTCPN-------AECQ------PLQLEHGSCQ-PVKEKYSFGEHITINCDVGYEVIGASYISCTA-NSWN 177

                         170
                  ....*....|..
gi 1622880766 256 AMPSCKASCKVP 267
Cdd:PHA02954  178 VIPSCQQKCDIP 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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