NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|967187406|ref|XP_014975597|]
View 

platelet endothelial cell adhesion molecule isoform X4 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-21

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 88.61  E-value: 1.86e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406  327 KPELETSFTRLDQGERLNLSCSIPGAPPANFTIQKGDTIVSQTQN-FTKIASKGDSGTYICTAGIDKVVKKSNTVQIVV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-127 2.57e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406    43 PDWTVQNGKNLTLQCCADVSTTSHV---KPQHQMLFYKDDvlfYNISSMKSTESYFIPEARVYDSGTYKCTViVNNKEKT 119
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVtwyKQGGKLLAESGR---FSVSRSGSTSTLTISNVTPEDSGTYTCAA-TNSSGSA 77


                   ....*...
gi 967187406   120 TSEYQVLV 127
Cdd:smart00410  78 SSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 509-583 1.21e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 1.21e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406   509 SNKVVESGEDIVLQCAVNeGSGPITYRFYREKEGKPFHQTTLNATQEFW----TKPKASKEQEGEYYCTAFNRANHASS 583
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGStstlTISNVTPEDSGTYTCAATNSSGSASS 79
Ig_C17orf99 super family cl39263
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 3.38e-05

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


The actual alignment was detected with superfamily member pfam17736:

Pssm-ID: 465476  Cd Length: 95  Bit Score: 43.25  E-value: 3.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967187406  423 KGQTIEVSCQSINGTSPISYHLLKTSKI-LENSTKNSSDPAVFKDNPTE-----DVEYQCVADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLVGSDGIvVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-21

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 88.61  E-value: 1.86e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406  327 KPELETSFTRLDQGERLNLSCSIPGAPPANFTIQKGDTIVSQTQN-FTKIASKGDSGTYICTAGIDKVVKKSNTVQIVV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-127 2.57e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406    43 PDWTVQNGKNLTLQCCADVSTTSHV---KPQHQMLFYKDDvlfYNISSMKSTESYFIPEARVYDSGTYKCTViVNNKEKT 119
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVtwyKQGGKLLAESGR---FSVSRSGSTSTLTISNVTPEDSGTYTCAA-TNSSGSA 77


                   ....*...
gi 967187406   120 TSEYQVLV 127
Cdd:smart00410  78 SSGTTLTV 85
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 43-127 4.55e-08

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 50.77  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406  43 PDWTVQNGKNLTLQCcadvsTTSHVKPQHQMLFYKDDVLFYNissMKSTESYFIPEARVYDSGTYKCTVIVNNKEKTTSE 122
Cdd:cd05753    7 PSAVVFEGEPLTLRC-----HGWKDKKVHKVTYYKDGKALKF---SYENSNFSIPQATLSDSGSYHCSGTVRIKRRSSES 78


                 ....*
gi 967187406 123 YQVLV 127
Cdd:cd05753   79 VNITV 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 509-583 1.21e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 1.21e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406   509 SNKVVESGEDIVLQCAVNeGSGPITYRFYREKEGKPFHQTTLNATQEFW----TKPKASKEQEGEYYCTAFNRANHASS 583
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGStstlTISNVTPEDSGTYTCAATNSSGSASS 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 340-399 1.42e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 1.42e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967187406   340 GERLNLSCSIPGAPPANFTIQKGD----------TIVSQTQNFT-KI--ASKGDSGTYICTAGIDKVVKKSNT 399
Cdd:smart00410   9 GESVTLSCEASGSPPPEVTWYKQGgkllaesgrfSVSRSGSTSTlTIsnVTPEDSGTYTCAATNSSGSASSGT 81
Ig_C17orf99 pfam17736
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 3.38e-05

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


Pssm-ID: 465476  Cd Length: 95  Bit Score: 43.25  E-value: 3.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967187406  423 KGQTIEVSCQSINGTSPISYHLLKTSKI-LENSTKNSSDPAVFKDNPTE-----DVEYQCVADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLVGSDGIvVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
IgC_CRIg cd16082
Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin ...
 339-404 5.69e-05

Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4)) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. CRIg plays a role in the complement system, an inhibitor of the alternative pathway convertases, and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins such as T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins such as butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409504  Cd Length: 86  Bit Score: 42.05  E-value: 5.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967187406 339 QGERLNLSCSIPGAPPANFTIQKGDTivsQTQNFTKIASKG----------DSGTYICTA-GIDKVVKKSNTVQIVV 404
Cdd:cd16082   12 QGMRISLQCQAWGSPPISYVWYKEQT---NNQEPIKVAALStllfkpavvaDSGSYFCTAkGRVGSEQRSDIVKFVV 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 506-590 1.74e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406  506 SILSNKVVESGEDIVLQCAVNEGSGPITYRFYREKEGKP-----FHQTTLNATQEFwTKPKASKEQEGEYYCTAFnraNH 580
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIeslkvKHDNGRTTQSSL-LISNVTKEDAGTYTCVVN---NP 76

                          90
                  ....*....|
gi 967187406  581 ASSVPRSKIL 590
Cdd:pfam00047  77 GGSATLSTSL 86
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-21

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 88.61  E-value: 1.86e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406  327 KPELETSFTRLDQGERLNLSCSIPGAPPANFTIQKGDTIVSQTQN-FTKIASKGDSGTYICTAGIDKVVKKSNTVQIVV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-127 2.57e-09

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 54.43  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406    43 PDWTVQNGKNLTLQCCADVSTTSHV---KPQHQMLFYKDDvlfYNISSMKSTESYFIPEARVYDSGTYKCTViVNNKEKT 119
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVtwyKQGGKLLAESGR---FSVSRSGSTSTLTISNVTPEDSGTYTCAA-TNSSGSA 77


                   ....*...
gi 967187406   120 TSEYQVLV 127
Cdd:smart00410  78 SSGTTLTV 85
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 43-127 4.55e-08

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 50.77  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406  43 PDWTVQNGKNLTLQCcadvsTTSHVKPQHQMLFYKDDVLFYNissMKSTESYFIPEARVYDSGTYKCTVIVNNKEKTTSE 122
Cdd:cd05753    7 PSAVVFEGEPLTLRC-----HGWKDKKVHKVTYYKDGKALKF---SYENSNFSIPQATLSDSGSYHCSGTVRIKRRSSES 78


                 ....*
gi 967187406 123 YQVLV 127
Cdd:cd05753   79 VNITV 83
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 509-583 1.21e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 1.21e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 967187406   509 SNKVVESGEDIVLQCAVNeGSGPITYRFYREKEGKPFHQTTLNATQEFW----TKPKASKEQEGEYYCTAFNRANHASS 583
Cdd:smart00410   2 PSVTVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGStstlTISNVTPEDSGTYTCAATNSSGSASS 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 340-399 1.42e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.03  E-value: 1.42e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967187406   340 GERLNLSCSIPGAPPANFTIQKGD----------TIVSQTQNFT-KI--ASKGDSGTYICTAGIDKVVKKSNT 399
Cdd:smart00410   9 GESVTLSCEASGSPPPEVTWYKQGgkllaesgrfSVSRSGSTSTlTIsnVTPEDSGTYTCAATNSSGSASSGT 81
Ig_C17orf99 pfam17736
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 3.38e-05

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


Pssm-ID: 465476  Cd Length: 95  Bit Score: 43.25  E-value: 3.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 967187406  423 KGQTIEVSCQSINGTSPISYHLLKTSKI-LENSTKNSSDPAVFKDNPTE-----DVEYQCVADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLVGSDGIvVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
IgC_CRIg cd16082
Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin ...
 339-404 5.69e-05

Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the Immunoglobulin (Ig) constant domain of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4)) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. CRIg plays a role in the complement system, an inhibitor of the alternative pathway convertases, and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins such as T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins such as butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409504  Cd Length: 86  Bit Score: 42.05  E-value: 5.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 967187406 339 QGERLNLSCSIPGAPPANFTIQKGDTivsQTQNFTKIASKG----------DSGTYICTA-GIDKVVKKSNTVQIVV 404
Cdd:cd16082   12 QGMRISLQCQAWGSPPISYVWYKEQT---NNQEPIKVAALStllfkpavvaDSGSYFCTAkGRVGSEQRSDIVKFVV 85
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 331-388 4.84e-04

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 39.40  E-value: 4.84e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406 331 ETSFTRLDQGERLNLSCSIPGAPPANFTIQKGDTIVSQTQ--NFTKIASKgDSGTYICTA 388
Cdd:cd20948    1 SPSDTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQelFLPAITEN-NEGTYTCSA 59
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 327-388 9.09e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 9.09e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 967187406  327 KPELETSF--TRLDQGERLNLSCSIPGAPPANFTIQKGDT-----------IVSQTQNFT-KIASKGDSGTYICTA 388
Cdd:pfam13927   1 KPVITVSPssVTVREGETVTLTCEATGSPPPTITWYKNGEpissgstrsrsLSGSNSTLTiSNVTRSDAGTYTCVA 76
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 506-590 1.74e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967187406  506 SILSNKVVESGEDIVLQCAVNEGSGPITYRFYREKEGKP-----FHQTTLNATQEFwTKPKASKEQEGEYYCTAFnraNH 580
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIeslkvKHDNGRTTQSSL-LISNVTKEDAGTYTCVVN---NP 76

                          90
                  ....*....|
gi 967187406  581 ASSVPRSKIL 590
Cdd:pfam00047  77 GGSATLSTSL 86
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 509-576 3.38e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967187406  509 SNKVVESGEDIVLQCAVnEGSGPITYRFYREKEGKPFHQTTLNATQEFWTK---PKASKEQEGEYYCTAFN 576
Cdd:pfam13927   9 SSVTVREGETVTLTCEA-TGSPPPTITWYKNGEPISSGSTRSRSLSGSNSTltiSNVTRSDAGTYTCVASN 78
I-set pfam07679
Immunoglobulin I-set domain;
340-388 7.28e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.47  E-value: 7.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967187406  340 GERLNLSCSIPGAPPANFTIQKGDTIVSQTQNFT----------KI--ASKGDSGTYICTA 388
Cdd:pfam07679  15 GESARFTCTVTGTPDPEVSWFKDGQPLRSSDRFKvtyeggtytlTIsnVQPDDSGKYTCVA 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH