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Conserved domains on  [gi|967184109|ref|XP_014975582|]
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sodium channel protein type 4 subunit alpha [Macaca mulatta]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999110)

sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
816-1026 7.46e-75

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 247.25  E-value: 7.46e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   816 DGEMNNLQIAIGRIKLGISFAKAFLLGLLHGKILSPKDimlslgepvgageageagetAPVDEKKEPPEEDLKKDSHILN 895
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQL--------------------PKKKPLTELKDARSKLTNQIAN 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   896 HMSLADDPPSSIEL--DHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLY--DGNSSVCSTADYK 971
Cdd:pfam06512   61 HTSLKKAPGGKYELdeDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEddDSSSSEGSTVDLQ 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 967184109   972 PPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFK 1026
Cdd:pfam06512  141 DPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1030-1304 3.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.59  E-value: 3.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1030 HNWFETFIVFMILLSSGALAFEDIYIEQRRvIRTILEYADKVFTYIFIMEMLLKWVAYGFKV-YFTNAWCWLDFLIVDVS 1108
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1109 IISLVANwlGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYY 1188
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1189 CINTttserfdisevnnkseceslmhtgqvrwLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREkeeqpqyevN 1268
Cdd:pfam00520  158 WENP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------E 200
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 967184109  1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
577-790 4.51e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.40  E-value: 4.51e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   577 DPFVDLGITICIVLNTLFMAMEHYPMTEH-FDHVLTVGNLVFTGIFTAEMVLKLIAMDP-YEYFQQGWNIFDSIIVTLSL 654
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   655 VELGLANVQ---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 731
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   732 KIALDCSLPRWHMYDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 790
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1353-1609 3.79e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.79e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1353 QAFDITIMILICLNMVTMMVETDDQSQLKV-DILYNINMIFIIIFTGECVLKMLALR--QYYFTVGWNIFDFVVVILSIV 1429
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLtTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1430 GLALSDliqkyFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV-- 1507
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1508 KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPpdcdpnlenpgtsvkgdcgnPSIGICFFCSYIIISFL 1587
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|..
gi 967184109  1588 IVVNMYIAIILENFNVATEESS 1609
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-457 7.29e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 7.29e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   130 HALFSMFIMITILTNCVFMTMSDPPP-------WSKNVEYTFTGIYTFESLIKILARGFCvddFTFLRDPWNWLDFSVIM 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   203 MAYLT----EFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLrq 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   279 kcvrwpppfndtnttwysndtwygndtwygnemwygndswyandtwnshaswatndtfdwdayindegnfyflegssdal 358
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   359 lcgnssdaghcpegyeciKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM-IFFVVIIFLGSFY 437
Cdd:pfam00520  156 ------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFL 217
                          330       340
                   ....*....|....*....|
gi 967184109   438 LINLILAVVAMAYAEQNEAT 457
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1296-1348 4.72e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.72e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 967184109 1296 DNFNQQKKKFGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYD 1348
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
816-1026 7.46e-75

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 247.25  E-value: 7.46e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   816 DGEMNNLQIAIGRIKLGISFAKAFLLGLLHGKILSPKDimlslgepvgageageagetAPVDEKKEPPEEDLKKDSHILN 895
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQL--------------------PKKKPLTELKDARSKLTNQIAN 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   896 HMSLADDPPSSIEL--DHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLY--DGNSSVCSTADYK 971
Cdd:pfam06512   61 HTSLKKAPGGKYELdeDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEddDSSSSEGSTVDLQ 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 967184109   972 PPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFK 1026
Cdd:pfam06512  141 DPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1030-1304 3.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.59  E-value: 3.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1030 HNWFETFIVFMILLSSGALAFEDIYIEQRRvIRTILEYADKVFTYIFIMEMLLKWVAYGFKV-YFTNAWCWLDFLIVDVS 1108
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1109 IISLVANwlGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYY 1188
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1189 CINTttserfdisevnnkseceslmhtgqvrwLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREkeeqpqyevN 1268
Cdd:pfam00520  158 WENP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------E 200
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 967184109  1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
577-790 4.51e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.40  E-value: 4.51e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   577 DPFVDLGITICIVLNTLFMAMEHYPMTEH-FDHVLTVGNLVFTGIFTAEMVLKLIAMDP-YEYFQQGWNIFDSIIVTLSL 654
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   655 VELGLANVQ---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 731
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   732 KIALDCSLPRWHMYDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 790
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1353-1609 3.79e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.79e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1353 QAFDITIMILICLNMVTMMVETDDQSQLKV-DILYNINMIFIIIFTGECVLKMLALR--QYYFTVGWNIFDFVVVILSIV 1429
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLtTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1430 GLALSDliqkyFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV-- 1507
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1508 KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPpdcdpnlenpgtsvkgdcgnPSIGICFFCSYIIISFL 1587
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|..
gi 967184109  1588 IVVNMYIAIILENFNVATEESS 1609
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-457 7.29e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 7.29e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   130 HALFSMFIMITILTNCVFMTMSDPPP-------WSKNVEYTFTGIYTFESLIKILARGFCvddFTFLRDPWNWLDFSVIM 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   203 MAYLT----EFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLrq 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   279 kcvrwpppfndtnttwysndtwygndtwygnemwygndswyandtwnshaswatndtfdwdayindegnfyflegssdal 358
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   359 lcgnssdaghcpegyeciKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM-IFFVVIIFLGSFY 437
Cdd:pfam00520  156 ------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFL 217
                          330       340
                   ....*....|....*....|
gi 967184109   438 LINLILAVVAMAYAEQNEAT 457
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1296-1348 4.72e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.72e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 967184109 1296 DNFNQQKKKFGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYD 1348
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
816-1026 7.46e-75

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 247.25  E-value: 7.46e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   816 DGEMNNLQIAIGRIKLGISFAKAFLLGLLHGKILSPKDimlslgepvgageageagetAPVDEKKEPPEEDLKKDSHILN 895
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQL--------------------PKKKPLTELKDARSKLTNQIAN 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   896 HMSLADDPPSSIEL--DHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLY--DGNSSVCSTADYK 971
Cdd:pfam06512   61 HTSLKKAPGGKYELdeDHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEddDSSSSEGSTVDLQ 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 967184109   972 PPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFK 1026
Cdd:pfam06512  141 DPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1030-1304 3.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.59  E-value: 3.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1030 HNWFETFIVFMILLSSGALAFEDIYIEQRRvIRTILEYADKVFTYIFIMEMLLKWVAYGFKV-YFTNAWCWLDFLIVDVS 1108
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1109 IISLVANwlGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYY 1188
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1189 CINTttserfdisevnnkseceslmhtgqvrwLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREkeeqpqyevN 1268
Cdd:pfam00520  158 WENP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------E 200
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 967184109  1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1304
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
577-790 4.51e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.40  E-value: 4.51e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   577 DPFVDLGITICIVLNTLFMAMEHYPMTEH-FDHVLTVGNLVFTGIFTAEMVLKLIAMDP-YEYFQQGWNIFDSIIVTLSL 654
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   655 VELGLANVQ---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 731
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   732 KIALDCSLPRWHMYDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGN 790
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1353-1609 3.79e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.79e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1353 QAFDITIMILICLNMVTMMVETDDQSQLKV-DILYNINMIFIIIFTGECVLKMLALR--QYYFTVGWNIFDFVVVILSIV 1429
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLtTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1430 GLALSDliqkyFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV-- 1507
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1508 KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPpdcdpnlenpgtsvkgdcgnPSIGICFFCSYIIISFL 1587
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|..
gi 967184109  1588 IVVNMYIAIILENFNVATEESS 1609
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
130-457 7.29e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 7.29e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   130 HALFSMFIMITILTNCVFMTMSDPPP-------WSKNVEYTFTGIYTFESLIKILARGFCvddFTFLRDPWNWLDFSVIM 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   203 MAYLT----EFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLrq 278
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   279 kcvrwpppfndtnttwysndtwygndtwygnemwygndswyandtwnshaswatndtfdwdayindegnfyflegssdal 358
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109   359 lcgnssdaghcpegyeciKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM-IFFVVIIFLGSFY 437
Cdd:pfam00520  156 ------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFL 217
                          330       340
                   ....*....|....*....|
gi 967184109   438 LINLILAVVAMAYAEQNEAT 457
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1296-1348 4.72e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 4.72e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 967184109 1296 DNFNQQKKKFGGK-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYD 1348
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1408-1602 2.88e-04

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 44.19  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1408 RQYYFTVGWNIFDFVVVILSIVGLALS--------DLIQKYFVSPTLF----RVIRLARIG-------------RVLRLI 1462
Cdd:pfam08016   36 RPSYLRSVWNLLDLAIVILSVVLIVLNiyrdfladRLIKSVEASPVTFidfdRVAQLDNLYriilaflvfltwlKLFKVL 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967184109  1463 RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAyvkkeSGIDdmfNFETFGNSIICLFEITTSA-GWDGL 1541
Cdd:pfam08016  116 RFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-----TQAP---NFSNFVKSILTLFRTILGDfGYNEI 187
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 967184109  1542 LNpilnsgppdcdpnlenpgtsvkgdcGNPSIGICFFCSYIIISFLIVVNMYIAIILENFN 1602
Cdd:pfam08016  188 FS-------------------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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