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Conserved domains on  [gi|967169799|ref|XP_014975461|]
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probable ATP-dependent RNA helicase DHX40 isoform X2 [Macaca mulatta]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-625 5.76e-144

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 440.29  E-value: 5.76e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:COG1643   57 RIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  81 LTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAI 160
Cdd:COG1643  137 LNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAV 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 161 VKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 240
Cdd:COG1643  209 ADAVREA-LAEEPGDILVFLPGEREIRRTAEAL-------------RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRR 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 320
Cdd:COG1643  275 RIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RP 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 321 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAV 400
Cdd:COG1643  354 AFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARML 433

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 401 IKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQkEAEQRHRELATKAGGFNDFATLAvifeqckssgapaswcqkhwiH 480
Cdd:COG1643  434 LAAAELGCLREAAILAALLSERDPRRGAAGSDLL-ARLNLWRRLREQQREFLSYLRLR---------------------E 491

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 481 WRclfsafRVEAQLRELIRKLKQQsdfpretfEGPKHEVLRRCLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSAL 559
Cdd:COG1643  492 WR------DLARQLRRLLGEGANE--------EPADYEAIGLLLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPL 555

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 560 HeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPKL--HEFNAHdlSSVARREVRedARRRWT 625
Cdd:COG1643  556 A----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAHLikRYSEPH--WDKKRGRVV--ARERVR 616
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-625 5.76e-144

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 440.29  E-value: 5.76e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:COG1643   57 RIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  81 LTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAI 160
Cdd:COG1643  137 LNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAV 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 161 VKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 240
Cdd:COG1643  209 ADAVREA-LAEEPGDILVFLPGEREIRRTAEAL-------------RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRR 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 320
Cdd:COG1643  275 RIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RP 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 321 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAV 400
Cdd:COG1643  354 AFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARML 433

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 401 IKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQkEAEQRHRELATKAGGFNDFATLAvifeqckssgapaswcqkhwiH 480
Cdd:COG1643  434 LAAAELGCLREAAILAALLSERDPRRGAAGSDLL-ARLNLWRRLREQQREFLSYLRLR---------------------E 491

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 481 WRclfsafRVEAQLRELIRKLKQQsdfpretfEGPKHEVLRRCLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSAL 559
Cdd:COG1643  492 WR------DLARQLRRLLGEGANE--------EPADYEAIGLLLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPL 555

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 560 HeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPKL--HEFNAHdlSSVARREVRedARRRWT 625
Cdd:COG1643  556 A----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAHLikRYSEPH--WDKKRGRVV--ARERVR 616
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-606 7.35e-109

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 357.54  E-value: 7.35e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799     1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:TIGR01967  113 LIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERS 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799    81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 160
Cdd:TIGR01967  193 LNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPLVEEQEDDDLDQLEAI 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   161 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPgiR 240
Cdd:TIGR01967  268 LD-AVDELFAEGPGDILIFLPGEREIRDAAEIL-------------RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--R 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 320
Cdd:TIGR01967  332 RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RP 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   321 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDR---SGHVTRLGLSMVEFPLPPHLT 397
Cdd:TIGR01967  411 EFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLTPIGRQLAQLPVDPRLA 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   398 CAVIKAASLDCEDLLLPIAAMLSVENVFIRPvdPEYQKEAEQRHRELATKAGGFNDFATLAVIFE---QCKSSGAPASWC 474
Cdd:TIGR01967  491 RMLLEAHRLGCLQEVLIIASALSIQDPRERP--MEKQQAADQAHARFKDPRSDFLSRVNLWRHIEeqrQALSANQFRNAC 568

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   475 QKHWIH------WRCLFSafrveaQLRELIRKLK-QQSDFPREtfegpkHEVLRRCLCAGYFKNVARRSVGRTFctmDG- 546
Cdd:TIGR01967  569 RKQYLNylrvreWQDIYR------QLTQVVKELGlKLNEEPAD------YDAIHKALLSGLLSQIGMKDEKHEY---DGa 633

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967169799   547 RGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL---HEFNAH 606
Cdd:TIGR01967  634 RGRKFHIFPGSPLFKKPPK--WVMAAELVETSKLYARLVAKIEPEWVEPVAGHLikkNYFEPH 694
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-600 5.26e-100

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 333.57  E-value: 5.26e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799    1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:PRK11131  120 LIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   81 LTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 160
Cdd:PRK11131  200 LNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAI 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  161 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMaesvdydyDVQDTTldgllILPCYGSMTTDQQRRIFlpPPPGIR 240
Cdd:PRK11131  275 FD-AVDELGREGPGDILIFMSGEREIRDTADALNKL--------NLRHTE-----ILPLYARLSNSEQNRVF--QSHSGR 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSK-DFWNQcm 319
Cdd:PRK11131  339 RIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEdDFLSR-- 416

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  320 PDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAI--DRSGHVTRL---GLSMVEFPLPP 394
Cdd:PRK11131  417 PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAIttDEQASAYKLtplGRQLAQLPVDP 496

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  395 HLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPeyQKEAEQRHRELATKAGGFNDFATL-AVIFEQCK--SSGAPA 471
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDK--QQASDEKHRRFADKESDFLAFVNLwNYLQEQQKalSSNQFR 574

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  472 SWCQKHWIHWrclfsaFRVE------AQLRELIRKLkqqsDFPRETFEGPKHEVlRRCLCAGYFKNVARRSVGRTFCTmD 545
Cdd:PRK11131  575 RLCRTDYLNY------LRVRewqdiyTQLRQVVKEL----GIPVNSEPAEYREI-HTALLTGLLSHIGMKDAEKQEYT-G 642

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 967169799  546 GRGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL 600
Cdd:PRK11131  643 ARNARFSIFPGSGLFKKPPK--WVMVAELVETSRLWGRIAARIEPEWIEPLAQHL 695
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 1-131 3.73e-87

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 270.57  E-value: 3.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17984   48 MIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17984  128 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 364-448 1.09e-18

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 81.51  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  364 ALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRE 443
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80


                  ....*
gi 967169799  444 LATKA 448
Cdd:pfam04408  81 RRAAD 85
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 370-458 4.88e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.15  E-value: 4.88e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   370 QCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRpvdpEYQKEAEQRHRELATKAG 449
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK----EKREDADAARRRFADPES 76


                   ....*....
gi 967169799   450 gfnDFATLA 458
Cdd:smart00847  77 ---DHLTLL 82
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-625 5.76e-144

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 440.29  E-value: 5.76e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:COG1643   57 RIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  81 LTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCnligPRDRENTAYIQAI 160
Cdd:COG1643  137 LNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYR----PLPADERDLEDAV 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 161 VKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 240
Cdd:COG1643  209 ADAVREA-LAEEPGDILVFLPGEREIRRTAEAL-------------RGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRR 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 320
Cdd:COG1643  275 RIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFAR-RP 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 321 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAV 400
Cdd:COG1643  354 AFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARML 433

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 401 IKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQkEAEQRHRELATKAGGFNDFATLAvifeqckssgapaswcqkhwiH 480
Cdd:COG1643  434 LAAAELGCLREAAILAALLSERDPRRGAAGSDLL-ARLNLWRRLREQQREFLSYLRLR---------------------E 491

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 481 WRclfsafRVEAQLRELIRKLKQQsdfpretfEGPKHEVLRRCLCAGYFKNVA-RRSVGRTFCTMDGRGspVHIHPSSAL 559
Cdd:COG1643  492 WR------DLARQLRRLLGEGANE--------EPADYEAIGLLLALAYPDRIArRRGEGGRYLLARGRG--AALFPGSPL 555

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 560 HeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPKL--HEFNAHdlSSVARREVRedARRRWT 625
Cdd:COG1643  556 A----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAHLikRYSEPH--WDKKRGRVV--ARERVR 616
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-606 7.35e-109

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 357.54  E-value: 7.35e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799     1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:TIGR01967  113 LIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERS 192

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799    81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 160
Cdd:TIGR01967  193 LNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPLVEEQEDDDLDQLEAI 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   161 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPgiR 240
Cdd:TIGR01967  268 LD-AVDELFAEGPGDILIFLPGEREIRDAAEIL-------------RKRNLRHTEILPLYARLSNKEQQRVFQPHSG--R 331

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMP 320
Cdd:TIGR01967  332 RIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNS-RP 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   321 DHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDR---SGHVTRLGLSMVEFPLPPHLT 397
Cdd:TIGR01967  411 EFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLTPIGRQLAQLPVDPRLA 490

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   398 CAVIKAASLDCEDLLLPIAAMLSVENVFIRPvdPEYQKEAEQRHRELATKAGGFNDFATLAVIFE---QCKSSGAPASWC 474
Cdd:TIGR01967  491 RMLLEAHRLGCLQEVLIIASALSIQDPRERP--MEKQQAADQAHARFKDPRSDFLSRVNLWRHIEeqrQALSANQFRNAC 568

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   475 QKHWIH------WRCLFSafrveaQLRELIRKLK-QQSDFPREtfegpkHEVLRRCLCAGYFKNVARRSVGRTFctmDG- 546
Cdd:TIGR01967  569 RKQYLNylrvreWQDIYR------QLTQVVKELGlKLNEEPAD------YDAIHKALLSGLLSQIGMKDEKHEY---DGa 633

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967169799   547 RGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL---HEFNAH 606
Cdd:TIGR01967  634 RGRKFHIFPGSPLFKKPPK--WVMAAELVETSKLYARLVAKIEPEWVEPVAGHLikkNYFEPH 694
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-600 5.26e-100

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 333.57  E-value: 5.26e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799    1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:PRK11131  120 LIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   81 LTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAI 160
Cdd:PRK11131  200 LNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAI 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  161 VKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMaesvdydyDVQDTTldgllILPCYGSMTTDQQRRIFlpPPPGIR 240
Cdd:PRK11131  275 FD-AVDELGREGPGDILIFMSGEREIRDTADALNKL--------NLRHTE-----ILPLYARLSNSEQNRVF--QSHSGR 338

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  241 KCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSK-DFWNQcm 319
Cdd:PRK11131  339 RIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEdDFLSR-- 416

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  320 PDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAI--DRSGHVTRL---GLSMVEFPLPP 394
Cdd:PRK11131  417 PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAIttDEQASAYKLtplGRQLAQLPVDP 496

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  395 HLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPeyQKEAEQRHRELATKAGGFNDFATL-AVIFEQCK--SSGAPA 471
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDK--QQASDEKHRRFADKESDFLAFVNLwNYLQEQQKalSSNQFR 574

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  472 SWCQKHWIHWrclfsaFRVE------AQLRELIRKLkqqsDFPRETFEGPKHEVlRRCLCAGYFKNVARRSVGRTFCTmD 545
Cdd:PRK11131  575 RLCRTDYLNY------LRVRewqdiyTQLRQVVKEL----GIPVNSEPAEYREI-HTALLTGLLSHIGMKDAEKQEYT-G 642

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 967169799  546 GRGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL 600
Cdd:PRK11131  643 ARNARFSIFPGSGLFKKPPK--WVMVAELVETSRLWGRIAARIEPEWIEPLAQHL 695
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 1-131 3.73e-87

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 270.57  E-value: 3.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17984   48 MIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17984  128 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 136-310 5.63e-71

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 227.80  E-value: 5.63e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 136 YPVREKFCNLIGPR-----DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDydydvqdtt 210
Cdd:cd18791    1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPD--------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 211 LDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSE 290
Cdd:cd18791   72 LGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151

                        170       180
                 ....*....|....*....|
gi 967169799 291 ALQRSGRAGRTSSGKCFRIY 310
Cdd:cd18791  152 AEQRAGRAGRTRPGKCYRLY 171
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 6-449 7.44e-70

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 243.29  E-value: 7.44e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   6 QPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDI 85
Cdd:PRK11664  55 EPRRLAARNVAQRLAEQLGEKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  86 LFGLLKKLfQEkspNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLiGPRDRENTAYIQAIVKVtm 165
Cdd:PRK11664 135 ALALLLDV-QQ---GLRDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPL-PAHQRFDEAVARATAEL-- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 166 dihLNEMAGDILVFLTGQFEIEKSCELLfqmAESVDYDYDvqdttldgllILPCYGSMTTDQQRRIFLPPPPGIRKCVIS 245
Cdd:PRK11664 208 ---LRQESGSLLLFLPGVGEIQRVQEQL---ASRVASDVL----------LCPLYGALSLAEQQKAILPAPAGRRKVVLA 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 246 TNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQcMPDHVIP 325
Cdd:PRK11664 272 TNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER-AAAQSEP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 326 EIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAAS 405
Cdd:PRK11664 351 EILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKE 430

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 967169799 406 LDceDLLLPIAAML-------------SVENVFIRPvDPEYQKEAEQRHRELATKAG 449
Cdd:PRK11664 431 DD--EAALATAAKLaaileepprsgssDLGVALSRK-QPHWQQRAQQLLKRLNVRGG 484
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-131 2.21e-66

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 215.40  E-value: 2.21e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17917   34 RIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERS 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17917  114 LDTDFLLGLLKDLLR-----KRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 1-131 3.71e-60

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 199.50  E-value: 3.71e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17978   48 MIGITQPRRVAAVSVAKRVAEEMGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERT 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17978  128 VHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-131 1.48e-58

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 194.99  E-value: 1.48e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17983   48 MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17983  128 LNTDVLFGLLREVVA-----RRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 1-132 1.96e-57

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 192.31  E-value: 1.96e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17971   53 KIGCTQPRRVAAMSVAKRVAEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERT 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 967169799  81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIP 132
Cdd:cd17971  133 IHTDVLFGLLKKTVQ-----KRPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-131 1.17e-53

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 182.23  E-value: 1.17e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17973   62 LVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERT 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17973  142 LATDILMGLLKEVVR-----RRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-131 4.07e-51

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 175.00  E-value: 4.07e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17974   49 KIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERT 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLfqekSPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17974  129 LHTDILFGLVKDI----ARFRPD-LKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 2-123 1.91e-46

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 162.64  E-value: 1.91e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK-ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17980   50 VGCTQPRRVAAVTVAGRVAEEMGAVLGHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERT 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 967169799  81 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFF 123
Cdd:cd17980  130 LYTDILIGLLKKIQK-----KRGDLRLIVASATLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 1-132 3.07e-44

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 156.75  E-value: 3.07e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKcTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17982   53 MIGITQPRRVAAVSMAKRVAEELN-VFGKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERS 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 967169799  81 LTTDILFGLL-------KKLFqeKSPNRKEHLKVVVMSATMelaKLSAFFGNCPIFDIP 132
Cdd:cd17982  132 VNTDILIGMLsrivplrAKLY--LQDQTVKPLKLVIMSATL---RVEDFTENKLLFPRP 185
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 1-131 1.15e-38

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 140.67  E-value: 1.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17989   48 LIGHTQPRRLAARSVAERIAEELKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERS 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17989  128 LNIDFLLGYLKQLL----PRRPD-LKVIITSATIDAERFSRHFNNAPIIEV 173
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 2-129 2.00e-35

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 131.69  E-value: 2.00e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 81
Cdd:cd17990   49 IIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSL 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 967169799  82 TTDILFGLLKKLFQEkspnRKEHLKVVVMSATMELAKLSAFFGNCPIF 129
Cdd:cd17990  129 DADLALALLLEVQQL----LRDDLRLLAMSATLDGDGLAALLPEAPVV 172
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 2-131 4.46e-32

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 122.17  E-value: 4.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 81
Cdd:cd17979   46 IACTQPRRIACISLAKRVAFESLNQYGSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHL 125

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 967169799  82 TTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17979  126 HGDFLLGVLRCLLR-----LRPDLKLILMSATINIELFSGYFEGAPVVQV 170
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 2-124 4.46e-31

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 119.91  E-value: 4.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 81
Cdd:cd17988   51 IVVTQPRRIAAISIARRVSQEREWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQ 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 967169799  82 TTDILFGLLKKLFQEKSpnrkEHLKVVVMSATMELAKLSAFFG 124
Cdd:cd17988  131 ELDFLLLVVRRLLRTNS----RHVKIILMSATISCKEFADYFT 169
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 2-131 5.09e-31

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 119.56  E-value: 5.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEM--KCTLGSKVGYQVRFDDCSSKETA-IKYMTDGCLLKHILGDPNLTKFSVIILDEAHE 78
Cdd:cd17981   53 IVCTQPRRISAISVAERVAAERaeSCGLGNSTGYQIRLESRKPRKQGsILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHE 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 967169799  79 RTLTTDILFGLLKKLFqekspNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17981  133 RNLQSDVLMGIVKDLL-----PFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 4-128 9.53e-29

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 112.96  E-value: 9.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   4 VTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDD-CSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLT 82
Cdd:cd17976   55 ITQPRRISAVSVAQRVAHELGPNLRRNVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVN 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 967169799  83 TDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPI 128
Cdd:cd17976  135 TDFLLILLKGVLQLNP-----ELRVVLMSATGDNQRLSRYFGGCPV 175
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 5-131 1.79e-28

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 112.24  E-value: 1.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   5 TQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTD 84
Cdd:cd17985   56 TQPRRISAISVAERVAQERAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESD 135

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 967169799  85 ILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17985  136 FLLLVLKDLMVQRP-----DLKVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-131 7.90e-28

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 110.30  E-value: 7.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17977   51 VVVCTQVHKQTAVWLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERT 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEkspnRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17977  131 VSTDVLLGLLKDVLLS----RPE-LKLVIITCPHLSSKLLSYYGNVPLIEV 176
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-131 2.45e-27

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 108.83  E-value: 2.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   1 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 80
Cdd:cd17986   52 QVTVTQPHPLAARSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERS 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMElAKLSAFFGNCPIFDI 131
Cdd:cd17986  132 VASDSLLGLLKDVRLQ----RPELRVVVVTSPALE-PKLRAFWGNPPVVHV 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 2-131 4.31e-26

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 105.77  E-value: 4.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLG-----SKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEA 76
Cdd:cd17975   54 IVCTQPRRISAMSLATRVCEELGCESGpggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEV 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 967169799  77 HERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17975  134 HERSVQSDFLLIILKEILHKRS-----DLHLILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 5-131 2.25e-25

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 103.37  E-value: 2.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   5 TQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHIL-GDPNLTKFSVIILDEAHERTLTT 83
Cdd:cd17987   54 TQPRRLAAIAVAERVAAERGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFS 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 967169799  84 DILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17987  134 DFLLTKLRDILQKHP-----NLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 2-131 4.26e-22

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 95.67  E-value: 4.26e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   2 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK-ETAIKYMTDGCLLKHIlgDPNLTKFSVIILDEAHERT 80
Cdd:cd17972  111 IVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKL--EAGIRGISHVIVDEIHERD 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 967169799  81 LTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 131
Cdd:cd17972  189 INTDFLLVVLRDVVQAYP-----DLRVILMSATIDTSMFCEYFFNCPVIEV 234
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 364-448 1.09e-18

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 81.51  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  364 ALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRE 443
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80


                  ....*
gi 967169799  444 LATKA 448
Cdd:pfam04408  81 RRAAD 85
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 520-600 1.13e-18

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 80.76  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  520 LRRCLCAGYFKNVARR-SVGRTFCTMDGrGSPVHIHPSSAL-HEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLL 597
Cdd:pfam07717   1 LRAALAAGLYPNVARRdPKGKGYTTLSD-NQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79


                  ...
gi 967169799  598 PKL 600
Cdd:pfam07717  80 PHI 82
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 370-458 4.88e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.15  E-value: 4.88e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   370 QCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRpvdpEYQKEAEQRHRELATKAG 449
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK----EKREDADAARRRFADPES 76


                   ....*....
gi 967169799   450 gfnDFATLA 458
Cdd:smart00847  77 ---DHLTLL 82
DEXDc smart00487
DEAD-like helicases superfamily;
4-137 7.01e-16

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 76.76  E-value: 7.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799     4 VTQPRKVAAISVAQRVAEEMKCTLGSKVGY------QVRFDDCSSKETAIKYMTDGCLLKHILGDP-NLTKFSVIILDEA 76
Cdd:smart00487  59 VLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEA 138

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 967169799    77 HERT--LTTDILFGLLKKLfqekspnrKEHLKVVVMSATM--ELAKLSAFFGNCPIFDIPGRLYP 137
Cdd:smart00487 139 HRLLdgGFGDQLEKLLKLL--------PKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
HELICc smart00490
helicase superfamily c-terminal domain;
213-300 3.41e-11

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 59.53  E-value: 3.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799   213 GLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEAL 292
Cdd:smart00490  11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYI 72


                   ....*...
gi 967169799   293 QRSGRAGR 300
Cdd:smart00490  73 QRIGRAGR 80
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 64-313 1.58e-09

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 61.15  E-value: 1.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  64 NLTKFSVIILDEAHERTLTTDILFGLLKKLfqeksPNRKEHLkvVVMSATME--LAKLSAFFGNcPIF-DIPG-RLYPVR 139
Cdd:PHA02653 288 KLFDYGTVIIDEVHEHDQIGDIIIAVARKH-----IDKIRSL--FLMTATLEddRDRIKEFFPN-PAFvHIPGgTLFPIS 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 140 EKFC-NLIGPRDR------ENTAYIQAIVKVTMDihlNEMAGDILVFLTGQfeieksCELLFQMAESVDYDYDV-----Q 207
Cdd:PHA02653 360 EVYVkNKYNPKNKrayieeEKKNIVTALKKYTPP---KGSSGIVFVASVSQ------CEEYKKYLEKRLPIYDFyiihgK 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799 208 DTTLDGLLilpcygsmttdqqRRIFLPPPPGIrkcVISTNISATSLTIDGIRYVVDGG--FVKQlnhnPRLGLDILevvp 285
Cdd:PHA02653 431 VPNIDEIL-------------EKVYSSKNPSI---IISTPYLESSVTIRNATHVYDTGrvYVPE----PFGGKEMF---- 486

                        250       260
                 ....*....|....*....|....*...
gi 967169799 286 ISKSEALQRSGRAGRTSSGKCFRIYSKD 313
Cdd:PHA02653 487 ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 161-300 6.14e-08

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 51.06  E-value: 6.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  161 VKVTMDIHLNEMAGDILVFLTGQFEIEksCELLFQmaesvdydydvqdttLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 240
Cdd:pfam00271   3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLE---------------KEGIKVARLHGDLSQEEREEILEDFRKGKI 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  241 KCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEALQRSGRAGR 300
Cdd:pfam00271  66 DVLVATDVAERGLDLPDVDLVINYDL------------------PWNPASYIQRIGRAGR 107
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 43-114 2.73e-03

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 39.15  E-value: 2.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 967169799   43 KETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHErtlTTDILFG-LLKKLFQEKSPNRkehlKVVVMSATM 114
Cdd:pfam00270  93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRLPKKR----QILLLSATL 158
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 67-192 3.59e-03

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 40.59  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 967169799  67 KFSVIILDEAH----ERTLTTDILFGLlkklfqeKSPNRkehlkvVVMSAT-MELaKLSAFFGncpIFDI--PGRLYPV- 138
Cdd:COG0553  358 DWDLVILDEAQhiknPATKRAKAVRAL-------KARHR------LALTGTpVEN-RLEELWS---LLDFlnPGLLGSLk 420

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 967169799 139 --REKFCNLIGPRDRENTAYIQAIVKVTMdihLNEMAGDILVFLTGQFEIEKSCEL 192
Cdd:COG0553  421 afRERFARPIEKGDEEALERLRRLLRPFL---LRRTKEDVLKDLPEKTEETLYVEL 473
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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