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Conserved domains on  [gi|1622876076|ref|XP_014974110|]
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protoheme IX farnesyltransferase, mitochondrial isoform X1 [Macaca mulatta]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 160-328 1.39e-72

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member PLN02776:

Pssm-ID: 469727  Cd Length: 341  Bit Score: 230.40  E-value: 1.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGP-FDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSGEaIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTPLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAGNdwektke 318
Cdd:PLN02776   81 WAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGA------- 153

                         170
                  ....*....|
gi 1622876076 319 RVLPACDYRW 328
Cdd:PLN02776  154 MVLAAALYFW 163
 
Name Accession Description Interval E-value
PLN02776 PLN02776
prenyltransferase
 160-328 1.39e-72

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 230.40  E-value: 1.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGP-FDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSGEaIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTPLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAGNdwektke 318
Cdd:PLN02776   81 WAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGA------- 153

                         170
                  ....*....|
gi 1622876076 319 RVLPACDYRW 328
Cdd:PLN02776  154 MVLAAALYFW 163
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 160-310 1.15e-70

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 222.70  E-value: 1.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGPF-DWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:cd13957     3 LTKPRITLLVLLTALAGYLLAPGGVpDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHALI 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTP-LKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:cd13957    83 FGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPlKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLG 155
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 160-310 2.97e-66

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 211.72  E-value: 2.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGP--FDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAV 237
Cdd:TIGR01473   6 LTKPRIISLLLITAFAGMWLAPGGalVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISPREAL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622876076 238 AFATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYT-PLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:TIGR01473  86 AFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLG 159
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 160-310 8.04e-53

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 177.63  E-value: 8.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGPF-DWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:COG0109    22 LTKPRIILLLLFTALAGMLLAAGGLpDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRISPREALI 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTP-LKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:COG0109   102 FGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLE 174
UbiA pfam01040
UbiA prenyltransferase family;
169-309 3.28e-44

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 153.54  E-value: 3.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 169 VVSTTAAGFALA-PGPFDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVAFATCCAVPG 247
Cdd:pfam01040   1 LLIPALAGLALAaGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 248 VAILtWGVNPLTGALGLFNIFLYTcCYT-PLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDA 309
Cdd:pfam01040  81 LLLL-LLLNPLTALLGLAALLLYV-LYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSP 141
 
Name Accession Description Interval E-value
PLN02776 PLN02776
prenyltransferase
 160-328 1.39e-72

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 230.40  E-value: 1.39e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGP-FDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSGEaIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTPLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAGNdwektke 318
Cdd:PLN02776   81 WAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGA------- 153

                         170
                  ....*....|
gi 1622876076 319 RVLPACDYRW 328
Cdd:PLN02776  154 MVLAAALYFW 163
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 160-310 1.15e-70

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 222.70  E-value: 1.15e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGPF-DWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:cd13957     3 LTKPRITLLVLLTALAGYLLAPGGVpDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHALI 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTP-LKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:cd13957    83 FGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPlKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLG 155
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 160-310 2.97e-66

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 211.72  E-value: 2.97e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGP--FDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAV 237
Cdd:TIGR01473   6 LTKPRIISLLLITAFAGMWLAPGGalVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISPREAL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622876076 238 AFATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYT-PLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:TIGR01473  86 AFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLG 159
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 160-310 8.04e-53

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 177.63  E-value: 8.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAPGPF-DWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:COG0109    22 LTKPRIILLLLFTALAGMLLAAGGLpDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRISPREALI 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTP-LKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:COG0109   102 FGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLE 174
UbiA pfam01040
UbiA prenyltransferase family;
169-309 3.28e-44

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 153.54  E-value: 3.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 169 VVSTTAAGFALA-PGPFDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVAFATCCAVPG 247
Cdd:pfam01040   1 LLIPALAGLALAaGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 248 VAILtWGVNPLTGALGLFNIFLYTcCYT-PLKRISIVNTWVGAVVGAIPPVMGWTAATGSLDA 309
Cdd:pfam01040  81 LLLL-LLLNPLTALLGLAALLLYV-LYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSP 141
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 160-310 1.16e-42

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 151.06  E-value: 1.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 160 LSKIKLTGLVVSTTAAGFALAP-GPFDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVA 238
Cdd:PRK04375   16 LTKPRVISLNLFTALGGMLLAPpGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALI 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622876076 239 FATCCAVPGVAILTWGVNPLTGALGLFNIFLYTCCYTP-LKRISIVNTWVGAVVGAIPPVMGWTAATGSLDAG 310
Cdd:PRK04375   96 FGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSWE 168
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 157-309 2.92e-21

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 92.60  E-value: 2.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 157 LARLSK-IKLTGLVVSTTAAGFALAPGPFDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLL 235
Cdd:COG0382     6 LLRLDRpIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLRE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622876076 236 AVAFATCCAVPGVAILTWgVNPLTGALGLFNIFLyTCCYTP-LKRISIV-NTWVGAVVGaIPPVMGWTAATGSLDA 309
Cdd:COG0382    86 ALLLAIVLLLLALALALL-LNPLTFLLALAALAL-AWAYSLfLKRFTLLgNLVLGLLFG-LGILMGFAAVTGSLPL 158
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 158-309 1.27e-16

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 79.05  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 158 ARLSKIKLTGLVVSTTAAGFALA---PGPFDWPCFLLASVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPL 234
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAaggLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622876076 235 LAVAFATCCAVPGVAILtWGVNPLTGALGLFNIFLyTCCYtPL-KRISIvntWVGAVVG---AIPPVMGWTAATGSLDA 309
Cdd:cd13959    81 EALLFLAVQLLLGLALL-LQLNPLTILLSPIALLL-VLIY-PLmKRFTY---WPQLVLGlafGWGPLMGWAAVTGSLPL 153
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 158-305 2.93e-10

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 60.44  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 158 ARLSKIKLTGLVVSTTAAGFALAPGPFDWPC--FLLASVGTGLASCAANSINQFFEVPFDSNMNRtkNRPLVRGQISPLL 235
Cdd:cd13956     1 LRLMRPYTLLYVLAPALAGAALAGAFAGPLPalLLLALLAVFLGAGAGYALNDYTDRELDAINKP--DRPLPSGRLSPRQ 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622876076 236 AVAFATCCAVPGVAiLTWGVNPLTGALGLFNIFLYTcCYT-PLKRISIVNTWVGAVVGAIPPVMGWTAATG 305
Cdd:cd13956    79 ALAFAAALLLVGLA-LALALGPLALLLLLAGLLLGL-AYSlGLKRLKLGGWGVLGYATGLALLPGLGAVAA 147
ubiA PRK12882
prenyltransferase; Reviewed
 175-294 1.03e-08

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 55.75  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 175 AGFALAPGPFDwpcfLLASVGTGLASCAANSINQFFEVPFDSnMNRtKNRPLVRGQISPLLAVAFATCCAVPGVAiLTWG 254
Cdd:PRK12882   30 AGGILSSPSLT----GLAFAAVFLATGAGNAINDYFDREIDR-INR-PDRPIPSGAVSPRGALAFSILLFAAGVA-LAFL 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622876076 255 VNPLTGALGLFN---IFLYTccyTPLKRISIV-NTWVGAVVGAI 294
Cdd:PRK12882  103 LPPLCLAIALFNsllLVLYA---ETLKGTPGLgNASVAYLTGST 143
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 157-308 2.44e-08

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 54.70  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 157 LARLSKIKLTGLVVSTTAAGFALAPGPFDWPCF-LLASVGTG--LASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISP 233
Cdd:PLN02809   12 LARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLkMLALFGCGalLLRGAGCTINDLLDRDIDKKVERTKLRPIASGALTP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 234 LLAVAFATCCAVPGVAILTWGVN--PLTGALGLFNIFLYtccytPL-KRISivnTWVGAVV------GAIppvMGWTAAT 304
Cdd:PLN02809   92 FQGVGFLGAQLLLGLGILLQLNNysRILGASSLLLVFTY-----PLmKRFT---FWPQAFLgltfnwGAL---LGWAAVK 160


                  ....
gi 1622876076 305 GSLD 308
Cdd:PLN02809  161 GSLD 164
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 173-303 3.38e-08

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 54.05  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 173 TAAGFALAPGP-FDWPCFLLASVGTGLASCAANSINQFFEVPFDSnMNRtKNRPLVRGQISPLLAVAFATCCAVPGVaIL 251
Cdd:cd13961    20 LGALFALGPLLsLNDLELLLLFLSVFLIAAAGYIINDYFDVEIDR-INK-PDRPIPSGRISRREALILSILLNALGL-IL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622876076 252 TWGVNPLTGALGLFNIFL---YTccyTPLKRISIVNTWVGAVVGAIPPVMGWTAA 303
Cdd:cd13961    97 AFLLSPLALLIALLNSLLlwlYS---HKLKRTPLIGNLLVALLTGLPFLFGGLAA 148
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 175-283 4.78e-07

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 50.94  E-value: 4.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 175 AGFALAPGPFDWPCFLLASVGTGLASCAANS---INQFFEVPFDSNMNRTKNRPLVRGQISPLLAVAFATCCAVPGVAiL 251
Cdd:cd13963    18 APLLFAGQLFDPDLLLAALLAFVAFCLAASAvyiLNDLLDLEADRLHPTKRNRPIASGRLSIPAALALAVVLLLAGLA-L 96

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622876076 252 TWGVNPLTGALGLFNIFLyTCCYT-PLKRISIV 283
Cdd:cd13963    97 ALLLSPAFLLVLLAYLVL-NLAYSlKLKRIPLL 128
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 170-309 2.07e-05

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 45.97  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 170 VSTTAAGFALA---PGPFDWPCFLLASVGTGLASCAANSINQFFEvpF----DSNMNRTKNRPLVRGQISP----LLAVA 238
Cdd:cd13962    13 LAPVLLGTALAyylGGFFNWLLFLLALLAALLLQIGVNLANDYFD--YkkgtDTEPRSGPSRVLVSGLLSPrqvlRAALV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 239 FATCCAVPGVaILTWGVNP---LTGALGLFNIFLYTccyTPLKRIS------IVntwVGAVVGAIPPVMGWTAATGSLDA 309
Cdd:cd13962    91 LLLLAALLGL-YLVALGGWlllLLGLLGILAGYFYT---GGPFPLSyrglgeLF---VFLFFGLLAVLGTYYVQTGSLSW 163
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
 168-271 2.14e-04

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 42.82  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 168 LVVSTTAAGFALA---PGPFDWPCFLLASVGTGLASCAANSINQFF--EVPFDSNMNRTKNRPLVRGQISP----LLAVA 238
Cdd:COG1575    13 AAVAPVLLGTALAyyeTGSFNWLLFLLALLAALLLQIGVNLANDYFdyKKGTDTEERVGPSRVIVSGLLSPkqvlRAALL 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622876076 239 FATCCAVPGVAiLTWGVNPLTGALGLFNIFL---YT 271
Cdd:COG1575    93 LLALALLLGLY-LVLLSGWPLLLLGLLGILAaifYT 127
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 157-307 2.81e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 42.18  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 157 LARLSKIkLTglVVSTTAAGFALAPGPFDWP----CFLLASVGTGLASCAansINQFFEVPFDSNmNRtKNRPLVRGQIS 232
Cdd:cd13964     4 LVRLPNL-FT--VPADVLAGAALAGGGLGPVlrlaLLLLASVLLYAAGMV---LNDVFDAELDAR-ER-PERPIPSGRVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 233 PLLAVAFATCCAVPGVaILTWGVNPLTGALGLF---NIFLYTccyTPLKRISI----------VNTWVGAVVGAIPPVMG 299
Cdd:cd13964    76 RGAALALGAGLLAAGV-ALAALVGRLSGLVALLlaaAILLYD---AWLKHTPLgpllmglcrgLNLLLGASAAAAGGLGP 151


                  ....*...
gi 1622876076 300 WTAATGSL 307
Cdd:cd13964   152 ALLAALAL 159
ubiA PRK12884
prenyltransferase; Reviewed
 190-309 7.98e-04

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 40.71  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 190 LLASVGTGLASCAANSINQFFEVPFDSnMNRTkNRPLVRGQISPLLAVAFATCCAVPGVaILTWGVNPLTGALGLFNIFL 269
Cdd:PRK12884   40 LLGFLTAFFASGSANALNDYFDYEVDR-INRP-DRPIPSGRISRREALLLAILLFILGL-IAAYLISPLAFLVVILVSVL 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1622876076 270 yTCCYT-PLKRISIV-NTWVGAVVGAiPPVMGWTAATGSLDA 309
Cdd:PRK12884  117 -GILYNwKLKEYGLIgNLYVAFLTGM-TFIFGGIAVGELNEA 156
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
173-307 6.42e-03

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 38.06  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622876076 173 TAAGFALAPGPFDWPCFLLasvGTGLASCAAN---SINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVAFATCCAV--PG 247
Cdd:PRK12874   33 VASKQKNDTGWFGFKLLIL---GILAAVSARNfamAFNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALifIG 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622876076 248 VAILtwgVNPLtgALGL-FNIFLYTCCYTPLKRISIVNTWVGAVVGAIPPVMGWTAATGSL 307
Cdd:PRK12874  110 VSYF---INPL--AFKLsFPFLIVLGGYSYFKRFSSLAHLVLGLSLGLAPIAGVVAVLGEI 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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