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Conserved domains on  [gi|966922324|ref|XP_014973963|]
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ethanolamine kinase 2 isoform X7 [Macaca mulatta]

Protein Classification

ethanolamine kinase( domain architecture ID 10142388)

ethanolamine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn)

CATH:  1.10.510.10
EC:  2.7.1.82
Gene Ontology:  GO:0004305|GO:0006646|GO:0005524
PubMed:  16244704

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 1-197 9.37e-91

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


:

Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 268.30  E-value: 9.37e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSL---PKPTLWHKMYNYFTLVKNEI----NPSLSADVPKVEVLEQELAWLKEHLSQLE-SPVVFCHNDL 72
Cdd:cd05157   98 LAELHSIVPLGEIegkKKPILWTTIRKWLDLAPEVFedekNKEKKLEKVDLERLRKELEWLEKWLESLEkSPIVFCHNDL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  73 LCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEV-DYCLYPARETQLQWLRYYLQA----QKGMAVTPRE 147
Cdd:cd05157  178 LYGNILYNEDDDSVTFIDFEYAGPNPRAFDIANHFCEWAGFYCVlDYSRYPTKEEQRNFLRAYLESldglPGGEEVSEEE 257

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966922324 148 VERLYVQVNKFALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKV 197
Cdd:cd05157  258 VEKLYNEVNLFRLASHLFWGLWALIQAAISSIDFDYLGYAKERLDEYWGD 307
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 1-197 9.37e-91

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 268.30  E-value: 9.37e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSL---PKPTLWHKMYNYFTLVKNEI----NPSLSADVPKVEVLEQELAWLKEHLSQLE-SPVVFCHNDL 72
Cdd:cd05157   98 LAELHSIVPLGEIegkKKPILWTTIRKWLDLAPEVFedekNKEKKLEKVDLERLRKELEWLEKWLESLEkSPIVFCHNDL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  73 LCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEV-DYCLYPARETQLQWLRYYLQA----QKGMAVTPRE 147
Cdd:cd05157  178 LYGNILYNEDDDSVTFIDFEYAGPNPRAFDIANHFCEWAGFYCVlDYSRYPTKEEQRNFLRAYLESldglPGGEEVSEEE 257

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966922324 148 VERLYVQVNKFALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKV 197
Cdd:cd05157  258 VEKLYNEVNLFRLASHLFWGLWALIQAAISSIDFDYLGYAKERLDEYWGD 307
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 3-204 4.85e-59

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 188.41  E-value: 4.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   3 KIHTIHANGSlPKPTLWHKMYNYF----TLVKNEINPSLSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCKNII 78
Cdd:PLN02421 117 RLHQVEIPGS-KEPQLWNDIFKFYekasTVKFEDPEKQKKYETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLM 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  79 YDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVnEVDYCLYPARETQLQWLRYYLQAQKGMAVTPREVERLYVQVNKF 158
Cdd:PLN02421 196 LNEDEGKLYFIDFEYGSYSYRGYDIGNHFNEYAGF-DCDYSLYPSKEEQYHFFRHYLRPDDPEEVSDAELEELFVETNFY 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 966922324 159 ALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKVKPQVSAL 204
Cdd:PLN02421 275 ALASHLYWAIWAIVQAKMSPIDFDYLGYFFLRYKEYKRQKEKLLSL 320
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 1-125 2.42e-41

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 139.33  E-value: 2.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324    1 MAKIHTIHANGSlPKPTLWHKMYNYFTLVKNEINP-----SLSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCK 75
Cdd:pfam01633  75 LAELHSLEMPGK-KSPSLWKTMRKWLSLLKNLGAPesvnkSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSG 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966922324   76 NIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNE-------VDYCLYPARE 125
Cdd:pfam01633 154 NILLLNETKRLVLIDFEYASYNYRGFDIANHFCEWAGDYHdptpffkCDYSLYPTRE 210
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
37-192 1.03e-19

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 81.75  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  37 LSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSiKGHVRFIDYEYAGYNYQAFDIGNHFNEFaGVNEv 116
Cdd:COG0510   21 LALGPRDLPELLRRLEELERALAARPLPLVLCHGDLHPGNFLVTD-DGRLYLIDWEYAGLGDPAFDLAALLVEY-GLSP- 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966922324 117 dyclyparETQLQWLRYYLqaqkGMAVTPREVERLYVqvnkFALASHFFWALWALIQNQYSTiHFDFLRYAVIRFN 192
Cdd:COG0510   98 --------EQAEELLEAYG----FGRPTEELLRRLRA----YRALADLLWALWALVRAAQEA-NGDLLKYLLRRLE 156
spore_CotS TIGR02906
spore coat protein, CotS family; Members of this family include the spore coat proteins CotS ...
 59-105 6.72e-03

spore coat protein, CotS family; Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination]


Pssm-ID: 131952 [Multi-domain]  Cd Length: 313  Bit Score: 36.49  E-value: 6.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966922324   59 SQLESPVVFCHNDLLCKNIIYDsiKGHVRFIDYEYAGYNYQAFDIGN 105
Cdd:TIGR02906 181 KEAKKIRGFCHQDYAYHNILLK--DNEVYVIDFDYCTIDLPVRDLRK 225
 
Name Accession Description Interval E-value
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 1-197 9.37e-91

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 268.30  E-value: 9.37e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSL---PKPTLWHKMYNYFTLVKNEI----NPSLSADVPKVEVLEQELAWLKEHLSQLE-SPVVFCHNDL 72
Cdd:cd05157   98 LAELHSIVPLGEIegkKKPILWTTIRKWLDLAPEVFedekNKEKKLEKVDLERLRKELEWLEKWLESLEkSPIVFCHNDL 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  73 LCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEV-DYCLYPARETQLQWLRYYLQA----QKGMAVTPRE 147
Cdd:cd05157  178 LYGNILYNEDDDSVTFIDFEYAGPNPRAFDIANHFCEWAGFYCVlDYSRYPTKEEQRNFLRAYLESldglPGGEEVSEEE 257

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966922324 148 VERLYVQVNKFALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKV 197
Cdd:cd05157  258 VEKLYNEVNLFRLASHLFWGLWALIQAAISSIDFDYLGYAKERLDEYWGD 307
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 3-204 4.85e-59

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 188.41  E-value: 4.85e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   3 KIHTIHANGSlPKPTLWHKMYNYF----TLVKNEINPSLSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCKNII 78
Cdd:PLN02421 117 RLHQVEIPGS-KEPQLWNDIFKFYekasTVKFEDPEKQKKYETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLM 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  79 YDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVnEVDYCLYPARETQLQWLRYYLQAQKGMAVTPREVERLYVQVNKF 158
Cdd:PLN02421 196 LNEDEGKLYFIDFEYGSYSYRGYDIGNHFNEYAGF-DCDYSLYPSKEEQYHFFRHYLRPDDPEEVSDAELEELFVETNFY 274

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 966922324 159 ALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKVKPQVSAL 204
Cdd:PLN02421 275 ALASHLYWAIWAIVQAKMSPIDFDYLGYFFLRYKEYKRQKEKLLSL 320
ChoK_euk cd05156
Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP ...
 1-199 1.74e-55

Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. Along with PCho, it is involved in malignant transformation through Ras oncogenes in various human cancers such as breast, lung, colon, prostate, neuroblastoma, and hepatic lymphoma. In mammalian cells, there are three ChoK isoforms (A-1, A-2, and B) which are active in homo- or heterodimeric forms. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270705 [Multi-domain]  Cd Length: 326  Bit Score: 178.97  E-value: 1.74e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSLPKPTLWHKMYNYFTLVKNEINPSLSADV------PKVEVLEQELAWLKEHLSQLESPVVFCHNDLLC 74
Cdd:cd05156  103 MARFHSLEMPISKEPKWLFDTMERWLKEALSILFTDEPTKPskqlelLLSYDLAKELGWLRSLLESTPSPVVFCHNDLQE 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  75 KNIIYDSIKGH-----VRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVD------YCL--YPARETQLQWLRYYLQAQKGM 141
Cdd:cd05156  183 GNILLLNGPENseddkLVLIDFEYCSYNYRGFDLANHFCEWAYDYTVPeppyfkINPenYPTREQQLHFIRAYLDEQYKD 262

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966922324 142 ------AVTPREVERLYVQVNKFALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKVKP 199
Cdd:cd05156  263 ktndltEERSKEEEKLLLEVNRFALASHFFWGLWSIVQAKISSIEFGYLEYAQARLDAYFKQKE 326
PLN02236 PLN02236
choline kinase
 1-201 2.37e-43

choline kinase


Pssm-ID: 177880 [Multi-domain]  Cd Length: 344  Bit Score: 148.27  E-value: 2.37e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSlPKPTLWHKMYNYFTLVKNEINPSLSADVpKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCKNIIYD 80
Cdd:PLN02236 138 LREFHSLDMPGP-KNVLLWDRLRNWLKEAKNLCSPEEAKEF-RLDSLEDEINLLEKELSGDDQEIGFCHNDLQYGNIMID 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  81 SIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAG------VNEVDYCLYPARETQLQWLRYYLQAQkGMAVTPREVERLYVQ 154
Cdd:PLN02236 216 EETRAITIIDYEYASYNPVAYDIANHFCEMAAdyhsetPHILDYSKYPGEEERRRFIRTYLSSS-GEEPSDEEVEQLLDD 294

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 966922324 155 VNKFALASHFFWALWALIQNQYSTIHFDFLRYAVIRFNQYFKVKPQV 201
Cdd:PLN02236 295 VEKYTLASHLFWGLWGIISGHVNKIDFDYMEYARQRFEQYWLRKPEL 341
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 1-125 2.42e-41

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 139.33  E-value: 2.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324    1 MAKIHTIHANGSlPKPTLWHKMYNYFTLVKNEINP-----SLSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCK 75
Cdd:pfam01633  75 LAELHSLEMPGK-KSPSLWKTMRKWLSLLKNLGAPesvnkSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSG 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966922324   76 NIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNE-------VDYCLYPARE 125
Cdd:pfam01633 154 NILLLNETKRLVLIDFEYASYNYRGFDIANHFCEWAGDYHdptpffkCDYSLYPTRE 210
ChoK-like_euk cd14021
Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline ...
 62-171 1.11e-31

Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline kinase, ethanolamine kinase, and similar proteins. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270923 [Multi-domain]  Cd Length: 229  Bit Score: 114.67  E-value: 1.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  62 ESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQL----QWLRY---- 133
Cdd:cd14021  109 TPPVVFCHNDLQENNILLTNDQDGLRLIDFEYSGFNYRGYDIANFFNESMIDYDHPEPPYFKIYKENyiseEEKRLfvsv 188

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966922324 134 YLQAQKGMAVTP---REVERLYVQVNKFALASHFFWALWAL 171
Cdd:cd14021  189 YLSEYLEKNVLPsldKLVEQFLQEVEIFTLGSHLYWGLWSI 229
PTZ00296 PTZ00296
choline kinase; Provisional
 1-194 9.78e-21

choline kinase; Provisional


Pssm-ID: 240350 [Multi-domain]  Cd Length: 442  Bit Score: 89.18  E-value: 9.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSLPK-----PTLWHKMYNYFTLVKNEINpsLSADVPKVEVLEQELAWLKEHLS------QLESPVVFCH 69
Cdd:PTZ00296 211 LGKFHTLSRKRHLPEhwdrtPCIFKMMEKWKNQLSKYKN--IEKYQRDIHKYIKESEKFIKFMKvysksdNLANDIVFCH 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  70 NDLLCKNIIyDSIKGhVRFIDYEYAGYNYQAFDIGNHFNEFAgvneVDYCL------------YPARETQLQWLRYYLQA 137
Cdd:PTZ00296 289 NDLQENNII-NTNKC-LRLIDFEYSGYNFLATDIANFFIETT----IDYSVshypffaidkkkYISYENRKLFITAYLSN 362

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966922324 138 --QKGMAV-TPREVERLYVQVNKFALASHFFWALWALIQNQYSTIH--FDFLRYAVIRFNQY 194
Cdd:PTZ00296 363 ylDKSLVVpNPKIIDQILEAVEVQALGAHLLWGFWSIIRGYQTKSYneFDFFLYAKERFKMY 424
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
37-192 1.03e-19

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 81.75  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  37 LSADVPKVEVLEQELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSiKGHVRFIDYEYAGYNYQAFDIGNHFNEFaGVNEv 116
Cdd:COG0510   21 LALGPRDLPELLRRLEELERALAARPLPLVLCHGDLHPGNFLVTD-DGRLYLIDWEYAGLGDPAFDLAALLVEY-GLSP- 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966922324 117 dyclyparETQLQWLRYYLqaqkGMAVTPREVERLYVqvnkFALASHFFWALWALIQNQYSTiHFDFLRYAVIRFN 192
Cdd:COG0510   98 --------EQAEELLEAYG----FGRPTEELLRRLRA----YRALADLLWALWALVRAAQEA-NGDLLKYLLRRLE 156
ChoK-like cd05151
Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic ...
 35-110 1.13e-16

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270700 [Multi-domain]  Cd Length: 152  Bit Score: 73.36  E-value: 1.13e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966922324  35 PSLSADVPKVEVLEQELAWLKE-HLSQLEsPVVFCHNDLLCKNIIYDsiKGHVRFIDYEYAGYNYQAFDIGNHFNEF 110
Cdd:cd05151   77 TLLTNDFSDPENLERIAALLRKlHSSPLE-DLVLCHNDLVPGNFLLD--DDRLYLIDWEYAGMNDPLFDLAALFSEN 150
PTZ00384 PTZ00384
choline kinase; Provisional
 54-174 2.29e-08

choline kinase; Provisional


Pssm-ID: 173576 [Multi-domain]  Cd Length: 383  Bit Score: 53.24  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  54 LKEHLSQLES---PVVFCHNDLLCKNIIyDSIKGhVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLY--------P 122
Cdd:PTZ00384 213 LNNHLNTSNSitnSVLFCHNDLFFTNIL-DFNQG-IYFIDFDFAGFNYVGWEIANFFVKLYIVYDPPTPPYfnsddslaL 290

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966922324 123 ARETQLQWLRYYLQAQKGMAVTPRE--VERLYVQVNKFALASHFFWALWALIQN 174
Cdd:PTZ00384 291 SEEMKTIFVSVYLSQLLGKNVLPSDdlVKEFLQSLEIHTLGVNLFWTYWGIVMN 344
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 54-110 2.53e-08

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 51.15  E-value: 2.53e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966922324  54 LKEHLSQLES--PVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEF 110
Cdd:cd05120   98 LAEILAALHRidSSVLTHGDLHPGNILVKPDGKLSGIIDWEFAGYGPPAFDYAAALRDW 156
HomoserineK_II cd05153
Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a ...
 1-171 2.55e-06

Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270702 [Multi-domain]  Cd Length: 300  Bit Score: 46.87  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324   1 MAKIHTIHANGSLPK-----PTLWHKmynYFTLVKNEINPSLSADVpkvEVLEQELAWLKEH-LSQLesPVVFCHNDLLC 74
Cdd:cd05153  117 LARLHLALAGFPPPRpnprgLAWWKP---LAERLKARLDLLAADDR---ALLEDELARLQALaPSDL--PRGVIHADLFR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  75 KNIIY--DSIKGhvrFIDYEYAGYNYQAFDIGNHFNEFAGvnEVDYCLYPARETQLqwLRYYlQAQKGMavTPREVERLY 152
Cdd:cd05153  189 DNVLFdgDRLSG---IIDFYDACYDPLLYDLAIALNDWCF--DDDGKLDPERAKAL--LAGY-QSVRPL--TEEEKAALP 258

                        170
                 ....*....|....*....
gi 966922324 153 VQvnkFALASHFFWALWAL 171
Cdd:cd05153  259 LL---LRAAALRFWLSRLY 274
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 2-108 2.97e-06

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 46.34  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324    2 AKIHTIHANGSlpKPTLWHKMYNYF-TLVKNEINPSLSADVPKV--EVLEQELAWLKEHLsQLESPVVFCHNDLLCKNII 78
Cdd:pfam01636 104 ARLHAVDPAAL--PLAGRLARLLELlRQLEAALARLLAAELLDRleELEERLLAALLALL-PAELPPVLVHGDLHPGNLL 180

                          90       100       110
                  ....*....|....*....|....*....|.
gi 966922324   79 YDSiKGHVR-FIDYEYAGYNYQAFDIGNHFN 108
Cdd:pfam01636 181 VDP-GGRVSgVIDFEDAGLGDPAYDLAILLN 210
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 45-106 2.88e-04

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 40.87  E-value: 2.88e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966922324  45 EVLEQELAWLKEHLSqLESPVVFCHNDLLCKNIIYDSIKGHVR-FIDYEYAGYNYQAFDIGNH 106
Cdd:COG3173  173 ALRERLAAWLAANLP-EWGPPVLVHGDLRPGNLLVDPDDGRLTaVIDWELATLGDPAADLAYL 234
spore_CotS TIGR02906
spore coat protein, CotS family; Members of this family include the spore coat proteins CotS ...
 59-105 6.72e-03

spore coat protein, CotS family; Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination]


Pssm-ID: 131952 [Multi-domain]  Cd Length: 313  Bit Score: 36.49  E-value: 6.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 966922324   59 SQLESPVVFCHNDLLCKNIIYDsiKGHVRFIDYEYAGYNYQAFDIGN 105
Cdd:TIGR02906 181 KEAKKIRGFCHQDYAYHNILLK--DNEVYVIDFDYCTIDLPVRDLRK 225
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
 45-171 7.77e-03

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 36.44  E-value: 7.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966922324  45 EVLEQELAWLKEHLSQLESPVVF--CHNDLLCKNIIYDSiKGHVRFIDYEYAGYNYQAFDIGnhfnefagvnevdYCLY- 121
Cdd:COG2334  157 ALLEELLDRLEARLAPLLGALPRgvIHGDLHPDNVLFDG-DGVSGLIDFDDAGYGPRLYDLA-------------IALNg 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966922324 122 -PARETQLQWLRYYLQA-QKGMAVTPREVERLYVQVnKFALASHFFWALWAL 171
Cdd:COG2334  223 wADGPLDPARLAALLEGyRAVRPLTEAELAALPPLL-RLRALRFLAWRLRRV 273
CotI COG5881
Spore coat protein CotI/CotS, protein kinase superfamily [Cell cycle control, cell division, ...
 67-105 8.59e-03

Spore coat protein CotI/CotS, protein kinase superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444583 [Multi-domain]  Cd Length: 331  Bit Score: 36.41  E-value: 8.59e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 966922324  67 FCHNDLLCKNIIYDSiKGHVRFIDYEYAGYNYQAFDIGN 105
Cdd:COG5881  203 FCHHDYAYHNILIDE-DGKIYIIDFDYCIYDLPVHDLAK 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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