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Conserved domains on  [gi|1622872723|ref|XP_014973264|]
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zinc finger protein GLIS3 isoform X2 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
573-720 5.57e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 573 EGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHL--------------DTKPYACQIPGCTKR 638
Cdd:COG5048    37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHnnpsdlnskslplsNSKASSSSLSSSSSN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 639 YTDPSSLRKHVKAHSSKDQQArKKLRSSTELHPDLLTDCLSVQPLQPATSPRDAAAEGTvgRSPGPGPDLYSAPIFSSNY 718
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQL-PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLISSNVS 193

                  ..
gi 1622872723 719 SS 720
Cdd:COG5048   194 TS 195
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
573-720 5.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 573 EGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHL--------------DTKPYACQIPGCTKR 638
Cdd:COG5048    37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHnnpsdlnskslplsNSKASSSSLSSSSSN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 639 YTDPSSLRKHVKAHSSKDQQArKKLRSSTELHPDLLTDCLSVQPLQPATSPRDAAAEGTvgRSPGPGPDLYSAPIFSSNY 718
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQL-PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLISSNVS 193

                  ..
gi 1622872723 719 SS 720
Cdd:COG5048   194 TS 195
zf-H2C2_2 pfam13465
Zinc-finger double domain;
584-611 2.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.37e-04
                          10        20
                  ....*....|....*....|....*...
gi 1622872723 584 NLKIHLRSHTGEKPYLCqhPGCQKAFSN 611
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
573-720 5.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 5.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 573 EGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHL--------------DTKPYACQIPGCTKR 638
Cdd:COG5048    37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHnnpsdlnskslplsNSKASSSSLSSSSSN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 639 YTDPSSLRKHVKAHSSKDQQArKKLRSSTELHPDLLTDCLSVQPLQPATSPRDAAAEGTvgRSPGPGPDLYSAPIFSSNY 718
Cdd:COG5048   117 SNDNNLLSSHSLPPSSRDPQL-PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLISSNVS 193

                  ..
gi 1622872723 719 SS 720
Cdd:COG5048   194 TS 195
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
559-653 2.99e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872723 559 MRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRshtgekpylcqHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIpgCTKR 638
Cdd:COG5189   341 MLKVKDGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKR 407
                          90
                  ....*....|....*
gi 1622872723 639 YTDPSSLRKHVKaHS 653
Cdd:COG5189   408 YKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
584-611 2.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.37e-04
                          10        20
                  ....*....|....*....|....*...
gi 1622872723 584 NLKIHLRSHTGEKPYLCqhPGCQKAFSN 611
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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