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Conserved domains on  [gi|966992276|ref|XP_014973024|]
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DDB1- and CUL4-associated factor 12 isoform X3 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
93-275 2.70e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  93 RQVVCGTKCNTLFVVDVQTSQITKIpilkdrepggVTQQGCGIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVcVGD 172
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRT----------LTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 173 DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKSDARHSVSrvpvyahithkalkdipkedtnpdnckVRALA 251
Cdd:COG2319  327 TGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTSVA 379

                        170       180
                 ....*....|....*....|....
gi 966992276 252 FNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
93-275 2.70e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  93 RQVVCGTKCNTLFVVDVQTSQITKIpilkdrepggVTQQGCGIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVcVGD 172
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRT----------LTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 173 DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKSDARHSVSrvpvyahithkalkdipkedtnpdnckVRALA 251
Cdd:COG2319  327 TGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTSVA 379

                        170       180
                 ....*....|....*....|....
gi 966992276 252 FNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-271 2.42e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  77 HLGTLNKVfaSQWLNHRQVVCGTKCNTLFVVDVQTSQITkipilkdREPGGVTQqgcGIHAIELNPSRTLLATGGDNpNS 156
Cdd:cd00200   50 HTGPVRDV--AASADGTYLASGSSDKTIRLWDLETGECV-------RTLTGHTS---YVSSVAFSPDGRILSSSSRD-KT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 157 LAIYRLPTldPVCVGD-DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTddvltksdarhsvSRVPVYAHITHkalkd 234
Cdd:cd00200  117 IKVWDVET--GKCLTTlRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLR-------------TGKCVATLTGH----- 176

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966992276 235 ipkedtnpdNCKVRALAFNSKNKELGAVSLDGYFHLW 271
Cdd:cd00200  177 ---------TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-203 8.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.91e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966992276   173 DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWE 203
Cdd:smart00320   9 KGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
93-275 2.70e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  93 RQVVCGTKCNTLFVVDVQTSQITKIpilkdrepggVTQQGCGIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVcVGD 172
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRT----------LTGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLATGKLL-RTL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 173 DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKSDARHSVSrvpvyahithkalkdipkedtnpdnckVRALA 251
Cdd:COG2319  327 TGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTSVA 379

                        170       180
                 ....*....|....*....|....
gi 966992276 252 FNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
134-274 1.43e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 134 GIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVCVGDdGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKS 212
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966992276 213 DARHSVSrvpvyahithkalkdipkedtnpdnckVRALAFNSKNKELGAVSLDGYFHLWKAE 274
Cdd:COG2319  242 LTGHSGS---------------------------VRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-271 2.42e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  77 HLGTLNKVfaSQWLNHRQVVCGTKCNTLFVVDVQTSQITkipilkdREPGGVTQqgcGIHAIELNPSRTLLATGGDNpNS 156
Cdd:cd00200   50 HTGPVRDV--AASADGTYLASGSSDKTIRLWDLETGECV-------RTLTGHTS---YVSSVAFSPDGRILSSSSRD-KT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 157 LAIYRLPTldPVCVGD-DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTddvltksdarhsvSRVPVYAHITHkalkd 234
Cdd:cd00200  117 IKVWDVET--GKCLTTlRGHTDWVNSVAFSPDgTFVASSSQDGTIKLWDLR-------------TGKCVATLTGH----- 176

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966992276 235 ipkedtnpdNCKVRALAFNSKNKELGAVSLDGYFHLW 271
Cdd:cd00200  177 ---------TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
134-275 2.77e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 134 GIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVCVGDdGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKS 212
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSAD-GTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRT 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966992276 213 DARHSVSrvpvyahithkalkdipkedtnpdnckVRALAFNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  284 LTGHSGG---------------------------VNSVAFSPDGKLLASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
134-275 8.94e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 8.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 134 GIHAIELNPSRTLLATGGDNpNSLAIYRLPTLDPVCVGDdGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKS 212
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRT 199

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966992276 213 DARHSVSrvpvyahithkalkdipkedtnpdnckVRALAFNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  200 LTGHTGA---------------------------VRSVAFSPDGKLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-272 1.86e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276  77 HLGTLNKVFASQwlNHRQVVCGTKCNTLFVVDVQTSQITKIpiLKDREpggvtqqgCGIHAIELNPSRTLLATGGDNpNS 156
Cdd:cd00200  134 HTDWVNSVAFSP--DGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHT--------GEVNSVAFSPDGEKLLSSSSD-GT 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 157 LAIYRLPTLDPVCVGDdGHKDWIFSIAWISDT-MAVSGSRDGSMGLWEVTDDVLTKSDARHSVSrvpvyahithkalkdi 235
Cdd:cd00200  201 IKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNS---------------- 263

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966992276 236 pkedtnpdnckVRALAFNSKNKELGAVSLDGYFHLWK 272
Cdd:cd00200  264 -----------VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-275 5.71e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 5.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 122 DREPGGVTQQGCGiHAIELN-----PSRTLLATGGDNpNSLAIYRLPTldPVCVGD-DGHKDWIFSIAWISD-TMAVSGS 194
Cdd:cd00200   37 DLETGELLRTLKG-HTGPVRdvaasADGTYLASGSSD-KTIRLWDLET--GECVRTlTGHTSYVSSVAFSPDgRILSSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 195 RDGSMGLWEVTDDVLTKSdarhsvsrvpVYAHithkalkdipkedtnpdNCKVRALAFNSKNKELGAVSLDGYFHLWKAE 274
Cdd:cd00200  113 RDKTIKVWDVETGKCLTT----------LRGH-----------------TDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165


                 .
gi 966992276 275 N 275
Cdd:cd00200  166 T 166
WD40 COG2319
WD40 repeat [General function prediction only];
134-275 3.78e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966992276 134 GIHAIELNPSRTLLATGGDnPNSLAIYRLPTLDPVCVGDdGHKDWIFSIAWISD-TMAVSGSRDGSMGLWEVTDDVLTKS 212
Cdd:COG2319   80 AVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRT 157

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966992276 213 DARHSVSrvpvyahithkalkdipkedtnpdnckVRALAFNSKNKELGAVSLDGYFHLWKAEN 275
Cdd:COG2319  158 LTGHSGA---------------------------VTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-203 8.91e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.91e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966992276   173 DGHKDWIFSIAWISD-TMAVSGSRDGSMGLWE 203
Cdd:smart00320   9 KGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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