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Conserved domains on  [gi|1622873613|ref|XP_014972753|]
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extracellular matrix protein 2 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-622 3.32e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 295 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitspgigpkAFKLLKKL 374
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 375 TRLNMDGNNLIQIPSELPS--TLEELKINENNLQAIDkESLSDLYQLVTLELEGNNLSEVnvnPLAFKPLKSLAYLRLGK 452
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 453 NKFRIIPQGL--PASIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 530
Cdd:COG4886   192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 531 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSVPPGIQE 608
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....
gi 1622873613 609 MKALHFLRLNNNKI 622
Cdd:COG4886   321 TTLLLLLLLLKGLL 334
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.65e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.65e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622873613 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-622 3.32e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 295 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitspgigpkAFKLLKKL 374
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 375 TRLNMDGNNLIQIPSELPS--TLEELKINENNLQAIDkESLSDLYQLVTLELEGNNLSEVnvnPLAFKPLKSLAYLRLGK 452
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 453 NKFRIIPQGL--PASIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 530
Cdd:COG4886   192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 531 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSVPPGIQE 608
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....
gi 1622873613 609 MKALHFLRLNNNKI 622
Cdd:COG4886   321 TTLLLLLLLLKGLL 334
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-551 1.42e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 299 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITS-PGIGPKAFKLLkkltr 376
Cdd:PRK15370  175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSiPATLPDTIQEM----- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 377 lNMDGNNLIQIPSELPSTLEELKINENNLQAIdKESLSDlyQLVTLELEGNNLS-----------EVNV--NPLAFKPLK 443
Cdd:PRK15370  247 -ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPET 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 444 ---SLAYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESID 520
Cdd:PRK15370  323 lppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLD 373

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1622873613 521 LSYNKLYHVPSYLPKSLLHLVLLGNQIERIP 551
Cdd:PRK15370  374 VSRNALTNLPENLPAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
322-384 1.48e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 71.40  E-value: 1.48e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622873613 322 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSpgIGPKAFKLLKKLTRLNMDGNNL 384
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.65e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.65e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622873613 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 3.68e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.38  E-value: 3.68e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622873613  103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 313-483 3.35e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 313 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSpgigpkafklLKKLTRLNMdgnnliqipsel 391
Cdd:cd21340    36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 392 pstLEELKINENNLQ-----AIDKESLSDL-YQLVTLELEGNNLSEvnvnplafkpLKSLAYLRlgknkfriipqglpaS 465
Cdd:cd21340    92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                         170
                  ....*....|....*...
gi 1622873613 466 IEELYLENNQIEEITEIC 483
Cdd:cd21340   144 LEQLDASNNQISDLEELL 161
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
295-622 3.32e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.34  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 295 LPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNitspgigpkAFKLLKKL 374
Cdd:COG4886    45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 375 TRLNMDGNNLIQIPSELPS--TLEELKINENNLQAIDkESLSDLYQLVTLELEGNNLSEVnvnPLAFKPLKSLAYLRLGK 452
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 453 NKFRIIPQGL--PASIEELYLENNQIEEITEicfnhtrkinvivlrynkieenriaPLAwiNQENLESIDLSYNKLYHVP 530
Cdd:COG4886   192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPE-------------------------PLA--NLTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 531 --SYLPKsLLHLVLLGNQIERIPgyVFGHMePGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSVPPGIQE 608
Cdd:COG4886   245 elGNLTN-LEELDLSNNQLTDLP--PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                         330
                  ....*....|....
gi 1622873613 609 MKALHFLRLNNNKI 622
Cdd:COG4886   321 TTLLLLLLLLKGLL 334
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
316-601 9.17e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 9.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 316 IPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSPGIGPKAFKLLKKLTRLNMDGNNLIQIPSELPSTL 395
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 396 EELKiNENNLQAIDKESLSDLYQLVTLELEGNNLSEVnvnPLAFKPLKSLAYLRLGKNKFRIIPQGLP--ASIEELYLEN 473
Cdd:COG4886    93 GDLT-NLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 474 NQIEEITEICFNHTrKINVIVLRYNKIEEnriAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQIERIP 551
Cdd:COG4886   169 NQLTDLPEELGNLT-NLKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622873613 552 GyvFGHMePGLEYLYLSFNKLADdgmdrVSFYGAYHSLRELFLDHNDLKS 601
Cdd:COG4886   245 E--LGNL-TNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
313-524 1.38e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 313 LTQIPPLTA--PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITSPgigPKAFKLLKKLTRLNMDGNNLIQIP-- 388
Cdd:COG4886   171 LTDLPEELGnlTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPel 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 389 SELPStLEELKINENNLQAIDKesLSDLYQLVTLELEGNNLSEVNVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPASIEE 468
Cdd:COG4886   247 GNLTN-LEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622873613 469 LYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYN 524
Cdd:COG4886   324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
299-551 1.42e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 86.67  E-value: 1.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 299 CSLSYRTISCINAM-LTQIPPLTAPQITSLELTGNSIASIPDeafNGLPNLERLDLSKNNITS-PGIGPKAFKLLkkltr 376
Cdd:PRK15370  175 CLKNNKTELRLKILgLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSiPATLPDTIQEM----- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 377 lNMDGNNLIQIPSELPSTLEELKINENNLQAIdKESLSDlyQLVTLELEGNNLS-----------EVNV--NPLAFKPLK 443
Cdd:PRK15370  247 -ELSINRITELPERLPSALQSLDLFHNKISCL-PENLPE--ELRYLSVYDNSIRtlpahlpsgitHLNVqsNSLTALPET 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 444 ---SLAYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEIcfnhtrkinvivlrynkieenrIAPlawinqeNLESID 520
Cdd:PRK15370  323 lppGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPET----------------------LPP-------TITTLD 373

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1622873613 521 LSYNKLYHVPSYLPKSLLHLVLLGNQIERIP 551
Cdd:PRK15370  374 VSRNALTNLPENLPAALQIMQASRNNLVRLP 404
LRR_8 pfam13855
Leucine rich repeat;
322-384 1.48e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 71.40  E-value: 1.48e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622873613 322 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSpgIGPKAFKLLKKLTRLNMDGNNL 384
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
348-612 2.01e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.13  E-value: 2.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 348 LERLDLSknniTSPGIGPKafkllkKLTRLNMDGNNLIQIPSELPSTLEELKINENNLQAIdKESLSDLYQLvtLELEGN 427
Cdd:PRK15370  185 LKILGLT----TIPACIPE------QITTLILDNNELKSLPENLQGNIKTLYANSNQLTSI-PATLPDTIQE--MELSIN 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 428 NLSEVNVN-PLAFKPL---------------KSLAYLRLGKNKFRIIPQGLPASIEELYLENNQIEEITEicfnhTRKIN 491
Cdd:PRK15370  252 RITELPERlPSALQSLdlfhnkisclpenlpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE-----TLPPG 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 492 VIVLrynKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNK 571
Cdd:PRK15370  327 LKTL---EAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLP----ENLPAALQIMQASRNN 399

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622873613 572 LADDGMDRVSFYGAYHSLRELFLDHNDLKSVPpgIQEMKAL 612
Cdd:PRK15370  400 LVRLPESLPHFRGEGPQPTRIIVEYNPFSERT--IQNMQRL 438
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
293-550 8.11e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.20  E-value: 8.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 293 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEafngLPN-LERLDLSKNNITS-PGIGPkafkl 370
Cdd:PRK15370  212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER----LPSaLQSLDLFHNKISClPENLP----- 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 371 lKKLTRLNMDGNNLIQIPSELPSTLEELKINENNLQAIdKESLSdlYQLVTLELEGNNLSEVnvnPLAFKPlkSLAYLRL 450
Cdd:PRK15370  283 -EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL-PETLP--PGLKTLEAGENALTSL---PASLPP--ELQVLDV 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 451 GKNKFRIIPQGLPASIEELYLENNQIEEITEicfnhtrkiNVivlrynkieenriaPLAwinqenLESIDLSYNKLyhvp 530
Cdd:PRK15370  354 SKNQITVLPETLPPTITTLDVSRNALTNLPE---------NL--------------PAA------LQIMQASRNNL---- 400

                         250       260
                  ....*....|....*....|
gi 1622873613 531 SYLPKSLLHLVLLGNQIERI 550
Cdd:PRK15370  401 VRLPESLPHFRGEGPQPTRI 420
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 103-157 9.65e-15

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 68.99  E-value: 9.65e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622873613 103 CLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQT--VIPEGECCPVC 157
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
313-528 5.26e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 313 LTQIP-PLTA-PQITSLELTGNSIASIPDEaFNGLPNLERLDLSKNNITS-PGIGpkafkLLKKLTRLNMDGNNLIQIPS 389
Cdd:COG4886   194 ITDLPePLGNlTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDlPELG-----NLTNLEELDLSNNQLTDLPP 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 390 ELPST-LEELKINENNLQAIDKESLSDLYQLVTLELEGNNLSEVNVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPASIEE 468
Cdd:COG4886   268 LANLTnLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 469 LYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYH 528
Cdd:COG4886   348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
VWC smart00214
von Willebrand factor (vWF) type C domain;
103-157 3.68e-12

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 61.38  E-value: 3.68e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622873613  103 CLVKGITMYNKAVWSPEPCTTCLCSDGR-VLCDETMCHP-QRCPQ--TVIPEGECCPVC 157
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNpeRVKPPGECCPRC 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 313-483 3.35e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 3.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 313 LTQIPPL-TAPQITSLELTGNSIASIpdEAFNGLPNLERLDLSKNNITSpgigpkafklLKKLTRLNMdgnnliqipsel 391
Cdd:cd21340    36 ITKIENLeFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISV----------VEGLENLTN------------ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 392 pstLEELKINENNLQ-----AIDKESLSDL-YQLVTLELEGNNLSEvnvnplafkpLKSLAYLRlgknkfriipqglpaS 465
Cdd:cd21340    92 ---LEELHIENQRLPpgeklTFDPRSLAALsNSLRVLNISGNNIDS----------LEPLAPLR---------------N 143

                         170
                  ....*....|....*...
gi 1622873613 466 IEELYLENNQIEEITEIC 483
Cdd:cd21340   144 LEQLDASNNQISDLEELL 161
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 371-553 4.11e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 371 LKKLTRLNMDGNNLIQIPS-ELPSTLEELKINENNLQAIdkESLSDLYQLVTLELEGNNLSEVNVnplaFKPLKSLAYLR 449
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN----LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 450 LGKNKFRIIpQGL--PASIEELYLENNQIEEITEICFNhTRKINVIV--LRYNKIEENRIAPLAWINQ-ENLESIDLSYN 524
Cdd:cd21340    75 LGGNRISVV-EGLenLTNLEELHIENQRLPPGEKLTFD-PRSLAALSnsLRVLNISGNNIDSLEPLAPlRNLEQLDASNN 152

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1622873613 525 KLYHVPSYLP-----KSLLHLVLLGNQIERIPGY 553
Cdd:cd21340   153 QISDLEELLDllsswPSLRELDLTGNPVCKKPKY 186
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 322-526 4.79e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 322 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSPGIGP--KAFKLLKKLTRLNMDGNNL-----IQIPSE 390
Cdd:COG5238   208 TTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIAlaEALKNNTTVETLYLSGNQIgaegaIALAKA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 391 L--PSTLEELKINENNLQAIDKESLSDLYQ----LVTLELEGNNLSEVNVNPL--AFKPLKSLAYLRLGKNKfrIIPQGL 462
Cdd:COG5238   288 LqgNTTLTSLDLSVNRIGDEGAIALAEGLQgnktLHTLNLAYNGIGAQGAIALakALQENTTLHSLDLSDNQ--IGDEGA 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622873613 463 PASIEelYLENNQieeiteicfnHTRKINvivLRYNKI-EENRIAPLAWINQENLESIDLSYNKL 526
Cdd:COG5238   366 IALAK--YLEGNT----------TLRELN---LGKNNIgKQGAEALIDALQTNRLHTLILDGNLI 415
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
291-551 2.95e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.18  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 291 GTLRLPSGCSLSYRTISCINAMLTQIPPLtAPQITSLELTGNSIASIPDEAfnglPNLERLDLSKNNITSPGIGPKAfkl 370
Cdd:PRK15387  212 GLTTLPDCLPAHITTLVIPDNNLTSLPAL-PPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSG--- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 371 lkkLTRLNMDGNNLIQIPSeLPSTLEELKINENNLQaidkeSLSDL-YQLVTLELEGNNLSEVNVNPlafkplKSLAYLR 449
Cdd:PRK15387  284 ---LCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLA-----SLPALpSELCKLWAYNNQLTSLPTLP------SGLQELS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 450 LGKNKFRIIPQgLPASIEELYLENNQIEEITEICFNHTRKInvivlrynkIEENRIAPLAWINQEnLESIDLSYNKLYHV 529
Cdd:PRK15387  349 VSDNQLASLPT-LPSELYKLWAYNNRLTSLPALPSGLKELI---------VSGNRLTSLPVLPSE-LKELMVSGNRLTSL 417

                         250       260
                  ....*....|....*....|..
gi 1622873613 530 PsYLPKSLLHLVLLGNQIERIP 551
Cdd:PRK15387  418 P-MLPSGLLSLSVYRNQLTRLP 438
LRR_8 pfam13855
Leucine rich repeat;
346-429 4.59e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 4.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 346 PNLERLDLSKNNITSpgIGPKAFKLLKKLTRLNmdgnnliqipselpstleelkINENNLQAIDKESLSDLYQLVTLELE 425
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLD---------------------LSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 1622873613 426 GNNL 429
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 323-622 5.67e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 5.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 323 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSPgIGPKAFKLLKKLTRLNMDGNNLI-QIPSELPSTLEELKIN 401
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP-IPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 402 ENNLQAIDKESLSDLYQLVTLELEGNNLseVNVNPLAFKPLKSLAYLRLGKNKFriiPQGLPASIEELylennqieeite 481
Cdd:PLN00113  149 NNMLSGEIPNDIGSFSSLKVLDLGGNVL--VGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQM------------ 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 482 icfnhtRKINVIVLRYNKIE---ENRIAPLAWINQenlesIDLSYNKLY-HVPSYLP--KSLLHLVLLGNQIE-RIPGYV 554
Cdd:PLN00113  212 ------KSLKWIYLGYNNLSgeiPYEIGGLTSLNH-----LDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSgPIPPSI 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622873613 555 FGHMEpgLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SVPPGIQEMKALHFLRLNNNKI 622
Cdd:PLN00113  281 FSLQK--LISLDLSDNSLSGEIPELVI---QLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKF 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
448-634 2.10e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 448 LRLGKNKFRIIPQGLPASIEELYLENNQIEEITEicfNHTRKINVIVLRYNK-----------IEE-----NRIAPLAWI 511
Cdd:PRK15370  183 LRLKILGLTTIPACIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQltsipatlpdtIQEmelsiNRITELPER 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 512 NQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPgyvfGHMEPGLEYLYLSFNKLaddgmdrvSFYGAY--HSL 589
Cdd:PRK15370  260 LPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLP----AHLPSGITHLNVQSNSL--------TALPETlpPGL 327

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1622873613 590 RELFLDHNDLKSVPPGIQemKALHFLRLNNNKIRCVSDAVLETVT 634
Cdd:PRK15370  328 KTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLPPTIT 370
LRR_8 pfam13855
Leucine rich repeat;
393-455 5.47e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.47e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622873613 393 STLEELKINENNLQAIDKESLSDLYQLVTLELEGNNLSEvnVNPLAFKPLKSLAYLRLGKNKF 455
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-531 6.07e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 309 INAMLTQIPPLTAPQITSLELTGnsiaSIPDEaFNGLPNLERLDLSKNNITspGIGPKAFKLLKKLTRLNMDGNNLI-QI 387
Cdd:PLN00113  324 IPVALTSLPRLQVLQLWSNKFSG----EIPKN-LGKHNNLTVLDLSTNNLT--GEIPEGLCSSGNLFKLILFSNSLEgEI 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 388 PSELP--STLEELKINENNLQAIDKESLSDLYQLVTLELEGNNLSEvNVNPLAFKpLKSLAYLRLGKNKFRiipQGLPAS 465
Cdd:PLN00113  397 PKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG-RINSRKWD-MPSLQMLSLARNKFF---GGLPDS 471

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622873613 466 -----IEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKLY-HVPS 531
Cdd:PLN00113  472 fgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLSHNQLSgQIPA 541
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
377-603 9.03e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.09  E-value: 9.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 377 LNMDGNNLIQIPSELPSTLEELKINENNLQaidkeSLSDL-YQLVTLELEGNNLSEVNV------------NPLAFKPL- 442
Cdd:PRK15387  206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT-----SLPALpPELRTLEVSGNQLTSLPVlppgllelsifsNPLTHLPAl 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 443 -KSLAYLRLGKNKFRIIPQgLPASIEELYLENNQIEEI----TEICfnhtrkinvIVLRYNkieeNRIAPLAWInQENLE 517
Cdd:PRK15387  281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASLpalpSELC---------KLWAYN----NQLTSLPTL-PSGLQ 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 518 SIDLSYNKLYHVPSyLPKSLLHLVLLGNQIERIPGyvfghMEPGLEYLYLSFNKLaddgmdrVSFYGAYHSLRELFLDHN 597
Cdd:PRK15387  346 ELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRL-------TSLPVLPSELKELMVSGN 412


                  ....*.
gi 1622873613 598 DLKSVP 603
Cdd:PRK15387  413 RLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
515-572 1.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.19e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622873613 515 NLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFGHMePGLEYLYLSFNKL 572
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 297-526 1.59e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 297 SGCSLSYRTISCINAMLTQIPPLTapqitSLELTGNSIASIPD------EAFNGLPNLERLDLSKNnitspGIGPKAFKL 370
Cdd:cd00116    31 EGNTLGEEAAKALASALRPQPSLK-----ELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDN-----ALGPDGCGV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 371 LKKLTRlnmdgnnliqipselPSTLEELKINENNLQ----AIDKESLSDLY-QLVTLELEGNNLSEVNVNPLA--FKPLK 443
Cdd:cd00116   101 LESLLR---------------SSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAkaLRANR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 444 SLAYLRLGKNK-----FRIIPQGLPAS--IEELYLENNQIEE----ITEICFNHTRKINVIVLRYNKIEENRIAPLAWIN 512
Cdd:cd00116   166 DLKELNLANNGigdagIRALAEGLKANcnLEVLDLNNNGLTDegasALAETLASLKSLEVLNLGDNNLTDAGAAALASAL 245

                         250
                  ....*....|....*..
gi 1622873613 513 QEN---LESIDLSYNKL 526
Cdd:cd00116   246 LSPnisLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
536-599 1.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622873613 536 SLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLadDGMDRVSFYGaYHSLRELFLDHNDL 599
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLL--TTLSPGAFSG-LPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 318-622 3.30e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 3.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 318 PLTAPQITSLE----LTGNSIASIPdEAFNGLPNLERLDLSKNNITSPgIGPKAFKLlKKLTRLNMDGNNLI-QIPSELP 392
Cdd:PLN00113  229 PYEIGGLTSLNhldlVYNNLTGPIP-SSLGNLKNLQYLFLYQNKLSGP-IPPSIFSL-QKLISLDLSDNSLSgEIPELVI 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 393 S--TLEELKINENNLQAIDKESLSDLYQLVTLELEGNNLS----------------EVNVNPLAFKPLKSLA------YL 448
Cdd:PLN00113  306 QlqNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgeipknlgkhnnltvlDLSTNNLTGEIPEGLCssgnlfKL 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 449 RLGKNKFR-IIPQGLPA--SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeENRIAPLAWiNQENLESIDLSYNK 525
Cdd:PLN00113  386 ILFSNSLEgEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL-QGRINSRKW-DMPSLQMLSLARNK 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 526 LY-HVP-SYLPKSLLHLVLLGNQIERIPGYVFGHMePGLEYLYLSFNKLADDGMDRVSfygAYHSLRELFLDHNDLK-SV 602
Cdd:PLN00113  464 FFgGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLSGEIPDELS---SCKKLVSLDLSHNQLSgQI 539

                         330       340
                  ....*....|....*....|
gi 1622873613 603 PPGIQEMKALHFLRLNNNKI 622
Cdd:PLN00113  540 PASFSEMPVLSQLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
562-629 5.12e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 5.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622873613 562 LEYLYLSFNKLADDGMDRVSFygayHSLRELFLDHNDLKSVPPGIQEMKALHFLRLNNNKIRCVSDAV 629
Cdd:COG4886   115 LESLDLSGNQLTDLPEELANL----TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 321-455 7.14e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 7.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 321 APQITSLELTGNSIASIPDE----AFNGLPNLERLDLSKNNITSPGIGP--KAFKLLKKLTRLNMDGNNL----IQIPSE 390
Cdd:cd00116   136 PPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEVLDLNNNGLtdegASALAE 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622873613 391 LPST---LEELKINENNL-----QAIDKESLSDLYQLVTLELEGNNLSEVNVNPLA--FKPLKSLAYLRLGKNKF 455
Cdd:cd00116   216 TLASlksLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAevLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
465-526 1.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622873613 465 SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIeeNRIAPLAWINQENLESIDLSYNKL 526
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
560-622 1.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622873613 560 PGLEYLYLSFNKLadDGMDRVSFYGAyHSLRELFLDHNDLKSVPPG-IQEMKALHFLRLNNNKI 622
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 469-627 1.75e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 469 LYLENNQIEEITEicFNHTRKINVIVLRYNKIEenRIaplawinqENLESidlsynklyhvpsyLPKsLLHLVLLGNQIE 548
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KI--------ENLEF--------------LTN-LTHLYLQNNQIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 549 RIPGyvFGHMePGLEYLYLSFNKLAddgmdRVSFYGAYHSLRELFLDHNDLksvPPGiQEM-----------KALHFLRL 617
Cdd:cd21340    60 KIEN--LENL-VNLKKLYLGGNRIS-----VVEGLENLTNLEELHIENQRL---PPG-EKLtfdprslaalsNSLRVLNI 127

                         170
                  ....*....|
gi 1622873613 618 NNNKIRCVSD 627
Cdd:cd21340   128 SGNNIDSLEP 137
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 346-393 3.24e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 3.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622873613 346 PNLERLDLSKNNITSpgIGPkaFKLLKKLTRLNMDGNNLIQIPSELPS 393
Cdd:pfam12799   1 PNLEVLDLSNNQITD--IPP--LAKLPNLETLDLSGNNKITDLSDLAN 44
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
295-437 3.60e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.08  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 295 LPSGcslsYRTISCINAMLTQIPPLTApQITSLELTGNSIASIPdeafnGLPN-LERLDLSKNNITSPGIGPKAFKllkk 373
Cdd:PRK15387  340 LPSG----LQELSVSDNQLASLPTLPS-ELYKLWAYNNRLTSLP-----ALPSgLKELIVSGNRLTSLPVLPSELK---- 405

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622873613 374 ltRLNMDGNNLIQIPSeLPSTLEELKINENNLQAIdKESLSDLYQLVTLELEGNNLSEVNVNPL 437
Cdd:PRK15387  406 --ELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPLSERTLQAL 465
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 321-636 4.67e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.32  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 321 APQITSLELTGNSI-----ASIPDEAFNGLPNLERLDLSKNNITSPGIgpkafKLLKKLTRLNMDGNNLIqipselpstL 395
Cdd:COG5238   150 PLGGNAVHLLGLAArlgllAAISMAKALQNNSVETVYLGCNQIGDEGI-----EELAEALTQNTTVTTLW---------L 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 396 EELKINENNLQAIdKESLSDLYQLVTLELEGNNLSEVNVNPLAfkplKSLAYlrlgknkfriipqglPASIEELYLENNQ 475
Cdd:COG5238   216 KRNPIGDEGAEIL-AEALKGNKSLTTLDLSNNQIGDEGVIALA----EALKN---------------NTTVETLYLSGNQ 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 476 IEEITEICFNHTRKINvIVLRYNKIEENRIAPLAWIN-----QEN--LESIDLSYNKLyhvpsylpksllhlvllGNQ-I 547
Cdd:COG5238   276 IGAEGAIALAKALQGN-TTLTSLDLSVNRIGDEGAIAlaeglQGNktLHTLNLAYNGI-----------------GAQgA 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 548 ERIpgyvFGHMEPG--LEYLYLSFNKLADDGMDRVSFYGAYH-SLRELFLDHNDLKSVppGIQEMKA------LHFLRLN 618
Cdd:COG5238   338 IAL----AKALQENttLHSLDLSDNQIGDEGAIALAKYLEGNtTLRELNLGKNNIGKQ--GAEALIDalqtnrLHTLILD 411

                         330
                  ....*....|....*...
gi 1622873613 619 NNKIRCVSDAVLETVTNR 636
Cdd:COG5238   412 GNLIGAEAQQRLEQLLER 429
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 322-469 7.16e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 7.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 322 PQITSLELTGNSI-ASIPDeaFNGLPNLERLDLSKNNITspGIGPKAFKLLKKLTRLNMDGNNLI-QIPSELpstleelk 399
Cdd:PLN00113  452 PSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQFS--GAVPRKLGSLSELMQLKLSENKLSgEIPDEL-------- 519

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622873613 400 inennlqaidkeslSDLYQLVTLELEGNNLS-EVnvnPLAFKPLKSLAYLRLGKNKFR-IIPQGLpASIEEL 469
Cdd:PLN00113  520 --------------SSCKKLVSLDLSHNQLSgQI---PASFSEMPVLSQLDLSQNQLSgEIPKNL-GNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 321-429 7.47e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 7.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 321 APQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITspGIGPKAFKLLKKLTRLNMDGNNLI-QIP---SELPsTLE 396
Cdd:PLN00113  474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS--GEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMP-VLS 550

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622873613 397 ELKINENNLQAIDKESLSDLYQLVTLELEGNNL 429
Cdd:PLN00113  551 QLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 471-631 1.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 471 LENNQIEEITEICFNHTRKINVIVlrynkieenRIAPLAWINQENLESIDLSYNKLYH-----VPSYLPKSLL-HLVL-- 542
Cdd:cd00116    47 LRPQPSLKELCLSLNETGRIPRGL---------QSLLQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLqELKLnn 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 543 --LGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS-FYGAYHSLRELFLDHNDLKsvPPGI----QEMKA---L 612
Cdd:cd00116   118 ngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAkALRANRDLKELNLANNGIG--DAGIralaEGLKAncnL 195

                         170
                  ....*....|....*....
gi 1622873613 613 HFLRLNNNKIRCVSDAVLE 631
Cdd:cd00116   196 EVLDLNNNGLTDEGASALA 214
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
103-143 2.17e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 39.85  E-value: 2.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622873613  103 CLVKGITMYNKAVWSpEPCTTCLCSDGRVLCDETMCHPQRC 143
Cdd:smart00215   1 CWNNGSYYPPGAKWD-DDCNRCTCLNGRVSCTKVWCGPKPC 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 322-357 6.65e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 6.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622873613 322 PQITSLELTGNSIASIPdeAFNGLPNLERLDLSKNN 357
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNN 34
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 313-623 1.27e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 313 LTQIPPLTAPQITSLEltGNSIASIPDEAFNGLPNLERLDLSKNNITspgigpkAFKLlkkltRLNMDGNNlIQIPSELP 392
Cdd:COG5238    15 LLSANPATTEQSELTK--RATIVNLRSYHLHGGAILLARYLQSRSSI-------TQYL-----RFEGQGDP-GLNPVALE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 393 STLE-----ELKINENNLQAIDKESLSDLYQLVT-----LELEGNNLSEVNVNPLA-----------FKPLKSLAYLRLG 451
Cdd:COG5238    80 KAAEafptqLLVVDWEGAEEVSPVALAETATAVAtpppdLRRIMAKTLEDSLILYLalprrinliqvLKDPLGGNAVHLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 452 KNKFRI--------IPQGLPASIEELYLENNQIEE--ITEICfNHTRK---INVIVLRYNKIEENRIAPLAWINQEN--L 516
Cdd:COG5238   160 GLAARLgllaaismAKALQNNSVETVYLGCNQIGDegIEELA-EALTQnttVTTLWLKRNPIGDEGAEILAEALKGNksL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 517 ESIDLSYNK-----LYHVPSYL--PKSLLHLVLLGNQIEripgyvfghmEPGLEYL--YLSFNKladdgmdrvsfygayh 587
Cdd:COG5238   239 TTLDLSNNQigdegVIALAEALknNTTVETLYLSGNQIG----------AEGAIALakALQGNT---------------- 292

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1622873613 588 SLRELFLDHNDL-----KSVPPGIQEMKALHFLRLNNNKIR 623
Cdd:COG5238   293 TLTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIG 333
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 324-445 1.50e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 324 ITSLELTgNSIASIPDEAFNGLPNLERLDLSkNNITSpgIGPKAFkllkkltrlnmDGNNLIQIpsELPSTLEElkinen 403
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLP-SSLTS--IGSYAF-----------YNCSLTSI--TIPSSLTS------ 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1622873613 404 nlqaIDKESLSDLYQLVTLELEgNNLSEVNVNPLAFKPLKSL 445
Cdd:pfam13306  70 ----IGEYAFSNCSNLKSITLP-SNLTSIGSYAFSNCSLKSI 106
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 322-399 1.95e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.93  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 322 PQITSLELTGNSI----ASIPDEAFNGLPNLERLDLSKNNITSPGigpkAFKLLK-----KLTRLNMDGNNL-IQIPSEL 391
Cdd:COG5238   348 TTLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQG----AEALIDalqtnRLHTLILDGNLIgAEAQQRL 423


                  ....*...
gi 1622873613 392 PSTLEELK 399
Cdd:COG5238   424 EQLLERIK 431
PLN03150 PLN03150
hypothetical protein; Provisional
 326-395 3.81e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 3.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 326 SLELTGNSIASIPDEAFNGLPNLERLDLSKNNITspGIGPKAFKLLKKLTRLNMDGNNLiqiPSELPSTL 395
Cdd:PLN03150  446 SINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN--GSIPESLGQLTSLRILNLNGNSL---SGRVPAAL 510
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 116-195 4.41e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.06  E-value: 4.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613 116 WSPEPC---TTCLCSDGRVLcdETMCH--PQRCPQT-----VIPEGECCPVCSAT----------EQREPTNLLHKQLPP 175
Cdd:pfam14828 186 VGPEACsdpSGCGCGNDENL--ERICAnvLQRCPPPhclspLRPEGHCCDVCGAIvsldysscfdLQTYRARLRHLFLAL 263

                          90       100
                  ....*....|....*....|....*
gi 1622873613 176 P-----QVGMDQIVRKEALQSEEDE 195
Cdd:pfam14828 264 PkykgvQLAVSKVGKDQRLHISDNE 288
IGFBP pfam00219
Insulin-like growth factor binding protein;
133-161 5.66e-03

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 35.38  E-value: 5.66e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622873613 133 CDETMC--HPQRCPQTVIPEG-ECCPVCSATE 161
Cdd:pfam00219   5 CDPERCppPPPGCPAGVVLDGcGCCKVCARQE 36
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 371-626 6.89e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 6.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613  371 LKKLTRLNMDGN-NLIQIPS-ELPSTLEELKINE-NNLQAIdKESLSDLYQLVTLELEG-NNLSEVnvnPLAFKpLKSLA 446
Cdd:PLN03210   633 LTGLRNIDLRGSkNLKEIPDlSMATNLETLKLSDcSSLVEL-PSSIQYLNKLEDLDMSRcENLEIL---PTGIN-LKSLY 707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613  447 YLRL-GKNKFRIIPQgLPASIEELYLENNQIEEI-TEICFNHTRKINVIVLRYNKIEENR--IAPLAWINQENLESIDLS 522
Cdd:PLN03210   708 RLNLsGCSRLKSFPD-ISTNISWLDLDETAIEEFpSNLRLENLDELILCEMKSEKLWERVqpLTPLMTMLSPSLTRLFLS 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622873613  523 YN-KLYHVPSYLpKSLLHLVLLG----NQIERIPGyvfGHMEPGLEYLYLSfnkladdGMDRV-SFYGAYHSLRELFLDH 596
Cdd:PLN03210   787 DIpSLVELPSSI-QNLHKLEHLEiencINLETLPT---GINLESLESLDLS-------GCSRLrTFPDISTNISDLNLSR 855

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1622873613  597 NDLKSVPPGIQEMKALHFLRLNN-NKIRCVS 626
Cdd:PLN03210   856 TGIEEVPWWIEKFSNLSFLDMNGcNNLQRVS 886
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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