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Conserved domains on  [gi|966986852|ref|XP_014970463|]
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hemopexin isoform X2 [Macaca mulatta]

Protein Classification

HX domain-containing protein( domain architecture ID 10056662)

HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 38-221 2.00e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 187.90  E-value: 2.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852  38 ERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWARELISETWKNFTSPVDAAFRHGHQ-SVFLIKGDKVWVYPPE 112
Cdd:cd00094    2 DAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDTgKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 113 KKEKGYPKLLQD-KFPGIPSPLDAAVECHRGEcqaeGILFFQGDHKWFWDLATGTMKKRY-------WSAVGN-CSSALR 183
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDPGYpklietdFPGVPDkVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 966986852 184 WL-GRYYCFQGNQFLRFNPVTGEVPPRYPLDVRDYFMPC 221
Cdd:cd00094  156 WLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 246-450 1.92e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 135.13  E-value: 1.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 246 RCSPhLVLSALMSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSTVDAAFSW--EEKLYLVQGTQVYVFLtkg 323
Cdd:cd00094    3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 324 GYTLVSGYPKRLEKeVGSPhgIILDSVDAAFVCPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 397
Cdd:cd00094   78 GKNLEPGYPKPISD-LGFP--PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966986852 398 CVEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakSPPQPQKVTS-LLGC 450
Cdd:cd00094  155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 38-221 2.00e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 187.90  E-value: 2.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852  38 ERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWARELISETWKNFTSPVDAAFRHGHQ-SVFLIKGDKVWVYPPE 112
Cdd:cd00094    2 DAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDTgKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 113 KKEKGYPKLLQD-KFPGIPSPLDAAVECHRGEcqaeGILFFQGDHKWFWDLATGTMKKRY-------WSAVGN-CSSALR 183
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDPGYpklietdFPGVPDkVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 966986852 184 WL-GRYYCFQGNQFLRFNPVTGEVPPRYPLDVRDYFMPC 221
Cdd:cd00094  156 WLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 246-450 1.92e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 135.13  E-value: 1.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 246 RCSPhLVLSALMSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSTVDAAFSW--EEKLYLVQGTQVYVFLtkg 323
Cdd:cd00094    3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 324 GYTLVSGYPKRLEKeVGSPhgIILDSVDAAFVCPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 397
Cdd:cd00094   78 GKNLEPGYPKPISD-LGFP--PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966986852 398 CVEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakSPPQPQKVTS-LLGC 450
Cdd:cd00094  155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 87-131 4.59e-11

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 57.64  E-value: 4.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 966986852    87 VDAAFRHGHQSVFLIKGDKVWVYPPEKKEKGYPKLLQDKFPGIPS 131
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 87-131 2.19e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 52.95  E-value: 2.19e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966986852   87 VDAAFRHGHQSVFLIKGDKVWVYPPEKKEKGYPKLLQDkFPGIPS 131
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-296 1.13e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.53  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 966986852   253 LSALMSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHQWPQGPS 296
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-296 5.03e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 5.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966986852  253 LSALMSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHqWPQGPS 296
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLISD-FPGLPC 44
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 38-221 2.00e-57

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 187.90  E-value: 2.00e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852  38 ERCsDGWSFDATTLDdNGTMLFFKGEFVWKSH----KWARELISETWKNFTSPVDAAFRHGHQ-SVFLIKGDKVWVYPPE 112
Cdd:cd00094    2 DAC-DPLSFDAVTTL-RGELYFFKGRYFWRLSpgkpPGSPFLISSFWPSLPSPVDAAFERPDTgKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 113 KKEKGYPKLLQD-KFPGIPSPLDAAVECHRGEcqaeGILFFQGDHKWFWDLATGTMKKRY-------WSAVGN-CSSALR 183
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNG----KTYFFKGDKYWRYDEKTQKMDPGYpklietdFPGVPDkVDAAFR 155

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 966986852 184 WL-GRYYCFQGNQFLRFNPVTGEVPPRYPLDVRDYFMPC 221
Cdd:cd00094  156 WLdGYYYFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 246-450 1.92e-37

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 135.13  E-value: 1.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 246 RCSPhLVLSALMSDNhGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSTVDAAFSW--EEKLYLVQGTQVYVFLtkg 323
Cdd:cd00094    3 ACDP-LSFDAVTTLR-GELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERpdTGKIYFFKGDKYWVYT--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966986852 324 GYTLVSGYPKRLEKeVGSPhgIILDSVDAAFVCPGSSRLHIMAGRRLWWLDLKSGAQA------TWTELPWPHEKVDGAL 397
Cdd:cd00094   78 GKNLEPGYPKPISD-LGFP--PTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDpgypklIETDFPGVPDKVDAAF 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966986852 398 CVEKSLgpnscsangpgLYLIHGPNLYCYSDVEKLNaakSPPQPQKVTS-LLGC 450
Cdd:cd00094  155 RWLDGY-----------YYFFKGDQYWRFDPRSKEV---RVGYPLKISSdWLGC 194
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 87-131 4.59e-11

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 57.64  E-value: 4.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 966986852    87 VDAAFRHGHQSVFLIKGDKVWVYPPEKKEKGYPKLLQDKFPGIPS 131
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 87-131 2.19e-09

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 52.95  E-value: 2.19e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966986852   87 VDAAFRHGHQSVFLIKGDKVWVYPPEKKEKGYPKLLQDkFPGIPS 131
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-296 1.13e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.53  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 966986852   253 LSALMSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHQWPQGPS 296
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRvDPGYPKLISSFFPGLPC 45
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 181-221 1.65e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.01  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 966986852  181 ALRW-LGRYYCFQGNQFLRFNPVTgeVPPRYPLDVRDY-FMPC 221
Cdd:pfam00045   4 AFEDrDGKTYFFKGRKYWRFDPQR--VEPGYPKLISDFpGLPC 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 253-296 5.03e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 5.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 966986852  253 LSALMSDNHGATYAFSGTHYWRLDTSR-DGWHSWPIAHqWPQGPS 296
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRvEPGYPKLISD-FPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 186-221 9.55e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 34.14  E-value: 9.55e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966986852   186 GRYYCFQGNQFLRFNPVTgeVPPRYPLDVRDYF--MPC 221
Cdd:smart00120  10 GKTYFFKGDKYWRFDPKR--VDPGYPKLISSFFpgLPC 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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