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Conserved domains on  [gi|966982087|ref|XP_014968235|]
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lactosylceramide alpha-2,3-sialyltransferase isoform X2 [Macaca mulatta]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 191-348 1.00e-105

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23983:

Pssm-ID: 480271  Cd Length: 211  Bit Score: 309.36  E-value: 1.00e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 271 FNWLQAMVKNETL-----------------------------------------------------NVPTIGVIAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLsfwsrlffwkevadsiplkpsqfrilnpliiketaldilqypepqsrlwgwdkNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966982087 298 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 191-348 1.00e-105

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 309.36  E-value: 1.00e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 271 FNWLQAMVKNETL-----------------------------------------------------NVPTIGVIAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLsfwsrlffwkevadsiplkpsqfrilnpliiketaldilqypepqsrlwgwdkNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966982087 298 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 156-353 3.72e-75

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 232.88  E-value: 3.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  156 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  236 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKNETL------------------------- 283
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVsrslrvlytlkevkipvdpdkvlfl 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  284 --------------------NVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETK 343
Cdd:pfam00777 167 hpdflryvanfwlrshglkgRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFK 246

                         250
                  ....*....|
gi 966982087  344 FLLKLVKEGV 353
Cdd:pfam00777 247 LLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 191-348 1.00e-105

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 309.36  E-value: 1.00e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 271 FNWLQAMVKNETL-----------------------------------------------------NVPTIGVIAVVLAT 297
Cdd:cd23983   81 FAWLKAMVKKEPLsfwsrlffwkevadsiplkpsqfrilnpliiketaldilqypepqsrlwgwdkNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966982087 298 HLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 191-348 2.85e-89

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 267.24  E-value: 2.85e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 271 FNWLQAMVKNETL-----------------------------------------------NVPTIGVIAVVLATHLCDEV 303
Cdd:cd23967   81 LLWLQAVIKGKKPngkggfwkkiatsvpkppkkirilnpyilqeaafdliglpmngkqgkNVPTTGIIAIVMALHYCDEV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 966982087 304 SLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23967  161 DIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 156-353 3.72e-75

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 232.88  E-value: 3.72e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  156 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  236 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKNETL------------------------- 283
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVsrslrvlytlkevkipvdpdkvlfl 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087  284 --------------------NVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETK 343
Cdd:pfam00777 167 hpdflryvanfwlrshglkgRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYGVHDMPFEFK 246

                         250
                  ....*....|
gi 966982087  344 FLLKLVKEGV 353
Cdd:pfam00777 247 LLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 191-348 6.16e-52

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 171.64  E-value: 6.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 271 FNWLQAMVKNETL-------------------------------------------------NVPTIGVIAVVLATHLCD 301
Cdd:cd23981   81 FKWLKYIVYKEKVsasdgfwksvatrvprepheirilnpyfiqeaafsfiglpfnnglmgrgNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 966982087 302 EVSLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 191-348 7.89e-52

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 171.00  E-value: 7.89e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSND-LFVAVLFKSV 269
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 270 DFNWLQAMVKNE---------------------------------------------TLNVPTIGVIAVVLATHLCDEVS 304
Cdd:cd23982   81 DFYWLYEILSNEkrvrkgfwkqppriwdanpkqirilnpyytyvaatkllqvpgqrkKKQKPTTGLLAITLALHLCDEVH 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 966982087 305 LAGFGYDLNQ-PRTPLHYFDNQCMAAM-NFQtmHNVTTETKFLLKL 348
Cdd:cd23982  161 IAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 192-348 1.24e-44

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 152.59  E-value: 1.24e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDF 271
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 272 NWLQAMVKNETLNV------------------------------------------------PTIGVIAVVLATHLCDEV 303
Cdd:cd23984   82 RWLLDLLMGKKVSAkgfwkkpalnliykpnqirilnpfilriaayellhfpkrfpkekkpkhPTTGIIAITLALHICNEV 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 966982087 304 SLAGFGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23984  162 HIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 156-355 3.46e-34

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 127.76  E-value: 3.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 156 SKYDPPFGFRKFS-SKVQTLLELL--PEHDLPEHLKA--KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 230
Cdd:cd23964   41 SHYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 231 SEHVGNKTTIRMTYPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKNET------------------------- 282
Cdd:cd23964  121 EKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPvpdgcdkgkrppplfgpklnatnvr 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 283 --------------LNV-----PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDNQCMAAMNFQTMHNVTTETK 343
Cdd:cd23964  201 llhpdfirylfnrwLNSstsyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVFYANHDFTNERK 277

                        250
                 ....*....|..
gi 966982087 344 FLLKLVKEGVVK 355
Cdd:cd23964  278 LWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 171-355 6.94e-27

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 107.37  E-value: 6.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 171 VQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23966   56 LEKLFQVVPGENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 251 SDLEYYsndlFVAVLFKSVDFNWL-------------------------QAMVKNETL-------------NVPTIGVIA 292
Cdd:cd23966  136 LDPGVH----LVLVPFKVLDLQWLisalttgeitrtytpvkrfikadkdKVLVINPAFikyvhdnwtehhgRYPSTGFLA 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966982087 293 VVLATHLCDEVSLAGFGYDLNQPRTplHYFDNQcMAAMNFQ--TMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23966  212 LIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKLAKEGKIR 273
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 195-348 1.82e-26

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 104.37  E-value: 1.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 195 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAP---------LSDLEYYSNDLFVAVL 265
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGfylrgprcgCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 266 FKSVDFNW----------------------LQAMVK---------NETLNVPTIGVIAVVLATHLCDEVSLAGFGYD-LN 313
Cdd:cd19952   81 AAAADFKRlkrrkkrhdnavllltdpapdlLSYVRKrleklglksFFGGNAPSSGLLAVLLALQLCDSVDLYGFGVDsGH 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 966982087 314 QPRTPLHYFDNQCMAAMNfqTMHNVTTETKFLLKL 348
Cdd:cd19952  161 APKVPYHYYDLVEAEEGT--AVHSFDLEAELLRAL 193
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 172-355 9.54e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 90.40  E-value: 9.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 172 QTLLELLPEHDLPEHlkaKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMT 243
Cdd:cd23963   46 KSLYELLPKTSPFSH---KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 244 YPEGAP-------LSDLEYYSNDLFVAVLFKSVDFN----WLQAMVKNETLNV-------------------------PT 287
Cdd:cd23963  123 YNSLKKnrdrdkfLNRLKEYNGSILWYPKFSFKSSTnlllKAARALKKNGLNLtvvysnpehflavqkfwkrrglekrPS 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966982087 288 IGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNqcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23963  203 TGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSPSTKNKVHNMPEEFKLLRELHKKGVLK 271
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 120-355 2.05e-20

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 89.93  E-value: 2.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 120 CRPKFAKTSMAMLFEHRYSVDLLPFVHKAPKDSETESKY-----DPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRR 194
Cdd:cd23979    3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 195 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 274
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 275 QAM------------------VKNETLNV--------------------PTIGVIAVVLATHLCDEVSLAGFGYDlnQPR 316
Cdd:cd23979  159 TSAlstgqirftyapvkqflrVDKDKVQIynpaffkyihdrwtehhgryPSTGMLVLFFALHVCDEVNVYGFGAD--SRG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966982087 317 TPLHYFDNQCMAAMNFQT-MHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23979  237 NWHHYWENNRYAGEFRKTgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 171-348 1.73e-18

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 84.55  E-value: 1.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 171 VQTLLELLP-EHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 249
Cdd:cd23980   59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 250 lSDLEYYSNDLFVAVLFKSVDFNWLQAMVKNETLN--------------------------------------VPTIGVI 291
Cdd:cd23980  136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIShtyvpvprkikvkkekiliyhpafikyvfdrwlqghgrYPSTGIL 214

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966982087 292 AVVLATHLCDEVSLAGFGYDlnQPRTPLHYFDNQCMAAMNFQT-MHNVTTETKFLLKL 348
Cdd:cd23980  215 SVIFSLHVCDEVDLYGFGAD--SKGNWHHYWENNPSAGAFRKTgVHDGDFESNVTTIL 270
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 173-355 7.38e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 79.74  E-value: 7.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 173 TLLELLPEHdlpEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 252
Cdd:cd23970   52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 253 LEYYSNDLF-----------------------------VAVLFKS-VDFNWLQAMVKNETLNVP---------------- 286
Cdd:cd23970  124 LEKYYNNLLtiqdrnnfflslkkldgailwipafffhtSATVTRTlVDFFVEHRGQLKVQLAWPgnimqhvnrywktkhl 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966982087 287 -----TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNQ-CMAAMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23970  204 spkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFVLLYKMHGAGVLK 281
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 187-348 1.36e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 78.85  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 187 LKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDLEYYSNDL 260
Cdd:cd23968   40 ENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 261 FV-------AVL---FKSVDFN------------------------------WLQAMVKNETL-NVPTIGVIAVVLATHL 299
Cdd:cd23968  120 LVwdpssynVNLekwYKKPDFDffpnyikyrrrhpeepfylidprflwrlwdILQEYTPEKIKpNPPSSGFIGIVLMLHL 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966982087 300 CDEVSLagFGYDLNQPRTPL-HYFDNQCMAAMNFQTMHNVTTETKFLLKL 348
Cdd:cd23968  200 CDWVDV--YEYVPSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 158-355 2.18e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 75.94  E-value: 2.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 158 YDPPFGFRKFS-SKVQTLLELLPEHDLPEHLKA-----KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 231
Cdd:cd23973   43 FNPPFGFMGLNyTLVKEVVELIPKPKEQQLLALsppggDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 232 EHVGNKTTIrmtYPEGAP--LSDLEYYSNDLF-----------VAVLFKSVDFNWLQAMVKNETLNV------------- 285
Cdd:cd23973  123 EDVGTRTSF---YVHTAHsiTSSLMILQKRGFknipqdkdikyILFPEGPRDYQWLEALLKNKTIPSgayygrrprsyfs 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 286 --------------------------------------PTIGVIAVVLATHLCDEVSLAGF---GYDlnqpRTPLHYFDN 324
Cdd:cd23973  200 gdftedkylvlhpdflryvknrflrsktlkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFiteDYR----KYPDHYYDK 275

                        250       260       270
                 ....*....|....*....|....*....|.
gi 966982087 325 QcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23973  276 K-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 172-355 1.05e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 70.52  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 172 QTLLELLPEHDlPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAP-- 249
Cdd:cd23969   47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPha 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 250 ----------------LSDLE------------------YYSNDLF------VAVLFKSVDFN------WLQAMVKnetL 283
Cdd:cd23969  124 ygdlvnatdkekfverLRQLGdsilwipafvskggeehvQWTNEIIlkhklnVKTAYPPLRLNhairgyWLTTKFR---I 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966982087 284 NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNFQtmHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23969  201 KRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMPEEFRALRSLHQRGALR 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 157-355 1.54e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 69.98  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 157 KYDppfGFRKFSSKV-QTLLELLPEhDLPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEgYSEHVG 235
Cdd:cd23971   34 HYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 236 NKT----------TIRMTYPEGAPLS---DLEYYSNDLF---------------------------VAVLF------KSV 269
Cdd:cd23971  107 SKTnlvtanpsilREKFHNLKKRRRPfveRMKVYGNALLllpafsytsntepslralytledfgspQKVLFfnpeylRNL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 270 DFNWLQAMVKNETLnvpTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDNQcmaaMNFQTMHNVTTETKFLL 346
Cdd:cd23971  187 SRYWKSKGLKARRL---STGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNV----LPKKGVHAMPEEFLRYL 259


                 ....*....
gi 966982087 347 KLVKEGVVK 355
Cdd:cd23971  260 KLHSQGVLR 268
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 165-355 1.59e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 69.98  E-value: 1.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 165 RKFSSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG--------N 236
Cdd:cd23988   40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 237 KTTIRMTYPEGAPLSDLEYYSNDLFV---AVLF----------KSVDfnWLQAMVKNETLNV------------------ 285
Cdd:cd23988  117 PSVVQRAFGGFRNESDREKFVHRLSMlndSVLWipafmvkggeKHVE--WVNALILKNKLKVrtaypslrlihavrgywl 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 286 --------PTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKLVKEGVV 354
Cdd:cd23988  195 tnkvnikrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGAL 274


                 .
gi 966982087 355 K 355
Cdd:cd23988  275 K 275
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 146-355 2.43e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 69.85  E-value: 2.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 146 HKAPKDSETESKYDPPFGFRKFSSK-VQTLLELLPEHD----LPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVI 220
Cdd:cd23972   31 HFTPALWDRLSQRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVF 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 221 RLNSAPVEGYSEHVGNKTTIR-----------MTY--------PEGAPL------SDLEYY----SNDLFVAV------- 264
Cdd:cd23972  111 RLNGAVIKGFEEDVGTKTSFYgftvntmknslISYwnlgftrtPQGQDLqyifipSDIRDYvmlrSAILGVPVpegldkg 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 265 --------------LFKSVDFNWLQAM----VKNETLN-------VPTIGVIAVVLATHLCDEVSLAGFGYDlNQPRTPL 319
Cdd:cd23972  191 drphkyfgpeasakKFKLLHPDFISYLtdrfLKSKLLNthyghlyMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSD 269

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966982087 320 HYFDNQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23972  270 HYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 192-243 4.09e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 64.96  E-value: 4.09e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMT 243
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 172-355 1.57e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 64.19  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 172 QTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS 251
Cdd:cd23987   47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 252 dLEYYSNDLFVAVLFKSVD--------------------FNWLQAMVKNETLNV-------------------------- 285
Cdd:cd23987  124 -FEDLVNETWKEKFLQRLQslngsilwipafmakggeerVEWVNDLILKHHINVrtaypslrllhavrgywltnkvhikr 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966982087 286 PTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDNQCMAAMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23987  203 PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 178-308 4.75e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 59.72  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 178 LPEHDLPEhlKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLS 251
Cdd:cd23985   33 LPKKSLRE--EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 252 DLEY------------YSNDLfvAVLFKSVDFNWLQAMVKNETL-------------------------------NVPTI 288
Cdd:cd23985  111 DSLYnegilivwdpapYHSDI--PEWYKNPDYNFFENYKTYRRLnpnqpfyilhpqmqwelwdiiqenspeeiqpNPPSS 188

                        170       180
                 ....*....|....*....|
gi 966982087 289 GVIAVVLATHLCDEVSLAGF 308
Cdd:cd23985  189 GMLGIILMMTLCDQVDVYEF 208
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 192-242 4.94e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.10  E-value: 4.94e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 242
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 192-250 1.06e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 57.95  E-value: 1.06e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 159-357 6.87e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 56.00  E-value: 6.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 159 DPPF---GFRKFSSKVQtlLELLPEHDLpehlkaKTCrrCVVIGSGGILHGlELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:cd23986   24 EAPFsalGWEKYVPKIP--LSKLHLRGF------RSC--AVVTSAGAILNS-SLGKEIDSHDAVLRFNSAPTRGYEKDVG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 236 NKTTIR------MTYPEGApLSDLEYYSNDLFVA-----------VLFKSVDFN-------------------------W 273
Cdd:cd23986   93 NKTTIRiinsqiLTNPNHH-FIDSSLYKDVILVAwdpapysanlhKWYKKPDYNlftpyvqyrkrnpnqpfyilhpkfiW 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 274 -LQAMVKNETL-----NVPTIGVIAVVLATHLCDEVSLAGFGYDLNQprTPL-HYFDNQCMAAMNFQTMHNVTTEtKFLL 346
Cdd:cd23986  172 qLWDIIQENTQekiqpNPPSSGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAACTLGAYHPLLYE-KLLI 248

                        250
                 ....*....|.
gi 966982087 347 KLVKEGVVKDL 357
Cdd:cd23986  249 QRMNKGTEDDL 259
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 193-355 1.42e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 55.15  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 193 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEG-YSEHVGNKT----------TIR-------------------- 241
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTnlvtanpsiiSIKyaklnerrkpfletvsvygd 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 242 -------MTYPEGAPLSDLEYYSNDLFVA---VLF------KSVDFNWLQAMVKNETLnvpTIGVIAVVLATHLCDEVSL 305
Cdd:cd23991  145 aflllpaFSYRSNTALSFKVYYTLEDFKAkqkVIFfhpiylKHLAQFWRSKGVQVYRL---STGLMITSAALELCEEVKL 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966982087 306 AGF-GYDLNQPRTPL--HYFDNQcMAAMNFqtmHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23991  222 YGFwPFSKNTEGKPIshHYYDNQ-LPKPGF---HSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 185-242 5.05e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 53.33  E-value: 5.05e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966982087 185 EHLKAKT-CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 242
Cdd:cd23976    7 DHKPLKMhCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRV 65
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 192-239 7.84e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 53.22  E-value: 7.84e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTT 239
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS 131
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 192-250 2.01e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.09  E-value: 2.01e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966982087 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 193-355 3.51e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 47.90  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 193 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPE------------------------- 246
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSiidkrfqnllwsrksfvesmkvygr 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 247 ------------GAPLSDLEYYSNDLFVA---VLFKSVDF-NWLQAMVKNETLNVP--TIGVIAVVLATHLCDEVSLAG- 307
Cdd:cd23989  144 syiympafsmktGTDPSLRVYYTLADVGAnqtVLFANPNFlRNVGKFWKSKGVHAKrlSTGLFLVSAALGLCEEVTIYGf 223

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966982087 308 --FGYDLNQPRTPLHYFDNQcmaaMNFQTMHNVTTETKFLLKLVKEGVVK 355
Cdd:cd23989  224 wpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 172-324 1.10e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 46.37  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 172 QTLLELLPEhDLPEHlkAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPE---- 246
Cdd:cd23990   47 SEIFKMFPK-DMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSiite 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966982087 247 --------GAPLSD-LEYYSN--------------DLFVAVLFKSVDFNWLQAMV---KNETLNV-------------PT 287
Cdd:cd23990  124 rfhklekwRRPFYEvLQVYENasvvlpafyntrntDVSIRVKYVLDDFESQQAVYyfhPQYLLNVsrfwlrqgvrakrIS 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 966982087 288 IGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDN 324
Cdd:cd23990  204 SGLMLVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDN 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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