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Conserved domains on  [gi|966980861|ref|XP_014967691|]
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sodium/calcium exchanger 1 isoform X12 [Macaca mulatta]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-934 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1750.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861    1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  641 DEY-DDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 719
Cdd:TIGR00845 634 ETItDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  720 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 799
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  800 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 879
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966980861  880 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 934
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-934 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1750.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861    1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  641 DEY-DDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 719
Cdd:TIGR00845 634 ETItDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  720 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 799
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  800 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 879
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966980861  880 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 934
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 1.39e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 1.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 966980861  330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 1.44e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.99  E-value: 1.44e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 966980861   483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
754-922 3.79e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.01  E-value: 3.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 754 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 833
Cdd:COG0530  146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 834 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 910
Cdd:COG0530  225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                        170
                 ....*....|..
gi 966980861 911 LFVLLWLLYIFF 922
Cdd:COG0530  281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 782-921 2.45e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 782 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 856
Cdd:PRK10734 200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966980861 857 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 921
Cdd:PRK10734 272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-934 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1750.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861    1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  641 DEY-DDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 719
Cdd:TIGR00845 634 ETItDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  720 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 799
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  800 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 879
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966980861  880 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 934
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 1.39e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 1.39e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 966980861  330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
403-493 2.54e-42

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 148.94  E-value: 2.54e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  403 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 966980861  483 EEDENFLVHLS 493
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 1.44e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.99  E-value: 1.44e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 966980861   483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 534-624 7.82e-26

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 101.95  E-value: 7.82e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARgGGEDFEDTCGELEFQNDEIVKIITIRIFDREEY 613
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 966980861   614 EKECSFSLVLE 624
Cdd:smart00237  80 EKDETFYVRLS 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 761-925 1.67e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.07  E-value: 1.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  761 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVF 840
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  841 LGIGVAWSIAAIYHAANGEqfkvspgTLAFSVTLFTIFAFINVGVLLYRRRpeiggelggPRTAKLLTSCLFVLLWLLYI 920
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLL-------KLDLGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 966980861  921 FFSSL 925
Cdd:pfam01699 145 VFQIV 149
Calx-beta pfam03160
Calx-beta domain;
534-623 1.32e-24

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 98.48  E-value: 1.32e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGA-RGNVIVPYKTIEGTARGGgEDFEDTCGELEFQNDEIVKIITIRIFDREE 612
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|.
gi 966980861  613 YEKECSFSLVL 623
Cdd:pfam03160  80 YEGDENFFVLL 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 77-248 3.13e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.35  E-value: 3.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   77 VYFVAMVYMFLGVSIIADRFMSSIEVITsqekeitikkpngettktTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  157 NftaGDLGPSTIVGSAAFNMFIIIALCVYV--VPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILsvisPGVVEVWEGLL 234
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 966980861  235 TFFFFPICVVFAWV 248
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
754-922 3.79e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.01  E-value: 3.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 754 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 833
Cdd:COG0530  146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 834 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 910
Cdd:COG0530  225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                        170
                 ....*....|..
gi 966980861 911 LFVLLWLLYIFF 922
Cdd:COG0530  281 LLLALYLAYLAL 292
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
774-923 3.58e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.99  E-value: 3.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 774 LLTAFIGDLASHFGctigLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGIGVAWSIAAIy 853
Cdd:COG0530    3 LLVRGADALARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIRPL- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 854 haangeqfKVSPGTLAFSVTLFTIFAFINVGVLLyrrrpeiggelggPRTAKLLTSCLFVLLWLLYIFFS 923
Cdd:COG0530   77 --------AVDRRVLRRDLPFLLLASLLLLALLL-------------DGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
134-252 2.82e-07

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.21  E-value: 2.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 134 LTLMALGSSAPEILLSVIEVCGHNFtagDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI--KHLRVFFVTAAwsifa 211
Cdd:COG0530   24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPLAVDRRVlrRDLPFLLLASL----- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966980861 212 ytwlyIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRR 252
Cdd:COG0530   96 -----LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-183 4.21e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 54.23  E-value: 4.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861    82 MVYMFLGVSIIADR-FMSSIEVITSQekeitikkpngettkttVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFTA 160
Cdd:TIGR00927  464 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVF---ISH 522

                           90       100
                   ....*....|....*....|...
gi 966980861   161 GDLGPSTIVGSAAFNMFIIIALC 183
Cdd:TIGR00927  523 SNVGIGTIVGSAVFNILFVIGTC 545
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 769-884 5.34e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.24  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  769 ILMIGLLTAFIG----------DLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVN 838
Cdd:TIGR00367   1 LLLIGYLILGLIlliygadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 966980861  839 VFLGIGVAWSIAAIYHAANGEQFKVsPGTLAFSVTLFTIFAFINVG 884
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDI-LFYLLVSILLLFFGLDGQIS 124
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 80-283 1.52e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.09  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   80 VAMVYMFLGVSII-ADRFMSSIEVITSqekeiTIKKPNgettkttvriwneTVSNLTLMALGSSAPEILLSVIEVCGHNf 158
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  159 taGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkikhlrvfFVTAAWSIFAYTWLYIILSVIspgvvevwegLLTFFF 238
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRRDILFYLLVSIL----------LLFFGL 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 966980861  239 F----PICVVFAWVAdrRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSK 283
Cdd:TIGR00367 120 DgqisRIDGVVLLIL--YIVYLLFLVKNERWVKYDTYTEENLDENNRRP 166
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 765-899 1.65e-04

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 44.62  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  765 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 844
Cdd:TIGR00367 175 LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE-LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLG 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966980861  845 VAWSIAAIyhaangeQFKVSPGTLAFSVTLFTIFAFinvgVLLYRRRPEIGGELG 899
Cdd:TIGR00367 254 VPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG 297
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 765-879 1.83e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861   765 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDqYADASIGNVTGSNAVNVFLGIG 844
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LGDMAVSSSVGSNIFDITVGLP 1016

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 966980861   845 VAWsiaAIYHAANGEQ-FKVSPG------TLAFSVTLFTIFA 879
Cdd:TIGR00927 1017 VPW---LLFSLINGLQpVPVSSNglfcaiVLLFLMLLFVISS 1055
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 782-921 2.45e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 782 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 856
Cdd:PRK10734 200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966980861 857 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 921
Cdd:PRK10734 272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 769-846 1.16e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 42.33  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 769 ILMIGLLTAFIGD-----LASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGI 843
Cdd:PRK10734   7 LLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLIL 85


                 ...
gi 966980861 844 GVA 846
Cdd:PRK10734  86 GLA 88
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 77-258 2.37e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 41.67  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861  77 VYFVAMVYMfLGvSIIADRFMSSIEVITSqekeiTIKKPngettkttvriwnETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:PLN03151 145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 157 NftAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKhlRVFFVTAAWSIFAYTWLYIILSVispGVVEVWEGLLtf 236
Cdd:PLN03151 205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVGGAIA-- 275

                        170       180
                 ....*....|....*....|..
gi 966980861 237 fFFPICVVFAWVADRRLLFYKY 258
Cdd:PLN03151 276 -FVSIYVVYAFLVAANEILRKH 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-245 4.76e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966980861 127 WNETVSNLTLMALGSSAPEILLSVIEVC-GHnftaGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkIKHLRVFFVTA 205
Cdd:COG0530  184 VSELVIGLTIVAIGTSLPELATSIVAARkGE----DDLAVGNIIGSNIFNILLVLGIGALITP------IPVDPAVLSFD 253

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966980861 206 AWSIFAYTWLYIILsVISPGVVEVWEGLLTFFFFPICVVF 245
Cdd:COG0530  254 LPVMLAATLLLLGL-LRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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