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Conserved domains on  [gi|966979949|ref|XP_014967256|]
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lysosomal-associated transmembrane protein 4A isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mtp super family cl04276
Golgi 4-transmembrane spanning transporter;
10-211 5.69e-81

Golgi 4-transmembrane spanning transporter;


The actual alignment was detected with superfamily member TIGR00799:

Pssm-ID: 470991  Cd Length: 258  Bit Score: 242.58  E-value: 5.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   10 RSDRFYSTrcCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTH-PNSMPAVNIQYEVI---------DNACVLFAVSVL 79
Cdd:TIGR00799   1 RSDRVRQT--CCCFNVRTATIALAIYHMVMSVLLFIEHTVEVAHgKNSCPAVNMQYLRIadlyssfllINALFIISVSLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   80 MFIISS--MLVYGAISYQVG-----------------------------WLIPFFCYRLFDFVLSCLVAISSLTYLP--R 126
Cdd:TIGR00799  79 MGVVKNreKYLYPFLSLQIMdfllclltllgsyielpaylklarprpgpSKIPLMTLQLLDFCLSILTLCSSYMEVPtyL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949  127 IKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVpeIAVYPAFEAPPQYVLPTYE 206
Cdd:TIGR00799 159 NFKSMNHMNYLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPASKMPPKVVLPSYE 236

                  ....*
gi 966979949  207 MAVKM 211
Cdd:TIGR00799 237 EALSL 241
 
Name Accession Description Interval E-value
mtp TIGR00799
Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions ...
10-211 5.69e-81

Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions and are located in late endosomal or lysosomal membranes. Substrates of the mouse MTP transporter include thymidine, both nucleoside and nucleobase analogues, antibiotics, anthracyclines, ionophores and steroid hormones. MET transporters may be involved in the subcellular compartmentation of steroid hormones and other compounds.Drug sensitivity by mouse MET was regulated by compounds that inhibit lysosomal function, interface with intracellular cholesterol transport, or modulate the multidrug resistance phenotype of mammalian cells. Thus, MET family members may compartmentalize diverse hydrophobic molecules, thereby affecting cellular drug sensitivity,nucleoside/nucleobase availability and steroid hormone responses. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273274  Cd Length: 258  Bit Score: 242.58  E-value: 5.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   10 RSDRFYSTrcCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTH-PNSMPAVNIQYEVI---------DNACVLFAVSVL 79
Cdd:TIGR00799   1 RSDRVRQT--CCCFNVRTATIALAIYHMVMSVLLFIEHTVEVAHgKNSCPAVNMQYLRIadlyssfllINALFIISVSLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   80 MFIISS--MLVYGAISYQVG-----------------------------WLIPFFCYRLFDFVLSCLVAISSLTYLP--R 126
Cdd:TIGR00799  79 MGVVKNreKYLYPFLSLQIMdfllclltllgsyielpaylklarprpgpSKIPLMTLQLLDFCLSILTLCSSYMEVPtyL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949  127 IKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVpeIAVYPAFEAPPQYVLPTYE 206
Cdd:TIGR00799 159 NFKSMNHMNYLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPASKMPPKVVLPSYE 236

                  ....*
gi 966979949  207 MAVKM 211
Cdd:TIGR00799 237 EALSL 241
Mtp pfam03821
Golgi 4-transmembrane spanning transporter;
38-211 1.66e-14

Golgi 4-transmembrane spanning transporter;


Pssm-ID: 461064  Cd Length: 229  Bit Score: 69.81  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   38 VVNLLMAILLTVEVTH-PNSMPAVNIQYEVIDNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLV 116
Cdd:pfam03821   1 VMSVLLLIEHSVEVAHgKGSCKGLKTGYYRIADIISSFLLIIMLFIISVSLLYGVLKNRERLLLPFLSLQIMDFLLCLLT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949  117 AISSLTYLP---------------RIKEYLDQLPDFPykDDLLALDSSCL------------------------------ 151
Cdd:pfam03821  81 LLGSYIELPaylkfasrsralgrsKVPLMALQLLDFC--LSILTLCSSYMevptylnfksmnhmnylpsqeglthnqfik 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966979949  152 -LFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPafEAPPQYVLPTYEMAVKM 211
Cdd:pfam03821 159 tMITFSIAFIAVLILKVYMFKCVWRCYKYIKAMNSGGVKVDS--KLLQKVVLPSYEEALSL 217
 
Name Accession Description Interval E-value
mtp TIGR00799
Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions ...
10-211 5.69e-81

Golgi 4-transmembrane spanning transporter; The proteins of the MET family have 4 TMS regions and are located in late endosomal or lysosomal membranes. Substrates of the mouse MTP transporter include thymidine, both nucleoside and nucleobase analogues, antibiotics, anthracyclines, ionophores and steroid hormones. MET transporters may be involved in the subcellular compartmentation of steroid hormones and other compounds.Drug sensitivity by mouse MET was regulated by compounds that inhibit lysosomal function, interface with intracellular cholesterol transport, or modulate the multidrug resistance phenotype of mammalian cells. Thus, MET family members may compartmentalize diverse hydrophobic molecules, thereby affecting cellular drug sensitivity,nucleoside/nucleobase availability and steroid hormone responses. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273274  Cd Length: 258  Bit Score: 242.58  E-value: 5.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   10 RSDRFYSTrcCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTH-PNSMPAVNIQYEVI---------DNACVLFAVSVL 79
Cdd:TIGR00799   1 RSDRVRQT--CCCFNVRTATIALAIYHMVMSVLLFIEHTVEVAHgKNSCPAVNMQYLRIadlyssfllINALFIISVSLL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   80 MFIISS--MLVYGAISYQVG-----------------------------WLIPFFCYRLFDFVLSCLVAISSLTYLP--R 126
Cdd:TIGR00799  79 MGVVKNreKYLYPFLSLQIMdfllclltllgsyielpaylklarprpgpSKIPLMTLQLLDFCLSILTLCSSYMEVPtyL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949  127 IKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVpeIAVYPAFEAPPQYVLPTYE 206
Cdd:TIGR00799 159 NFKSMNHMNYLPSQEDLPHLQFICMMFIFSVAFITVLIFKVYMFKCVWNCYKYIKNMNS--IAEYPASKMPPKVVLPSYE 236

                  ....*
gi 966979949  207 MAVKM 211
Cdd:TIGR00799 237 EALSL 241
Mtp pfam03821
Golgi 4-transmembrane spanning transporter;
38-211 1.66e-14

Golgi 4-transmembrane spanning transporter;


Pssm-ID: 461064  Cd Length: 229  Bit Score: 69.81  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949   38 VVNLLMAILLTVEVTH-PNSMPAVNIQYEVIDNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLV 116
Cdd:pfam03821   1 VMSVLLLIEHSVEVAHgKGSCKGLKTGYYRIADIISSFLLIIMLFIISVSLLYGVLKNRERLLLPFLSLQIMDFLLCLLT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966979949  117 AISSLTYLP---------------RIKEYLDQLPDFPykDDLLALDSSCL------------------------------ 151
Cdd:pfam03821  81 LLGSYIELPaylkfasrsralgrsKVPLMALQLLDFC--LSILTLCSSYMevptylnfksmnhmnylpsqeglthnqfik 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966979949  152 -LFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPafEAPPQYVLPTYEMAVKM 211
Cdd:pfam03821 159 tMITFSIAFIAVLILKVYMFKCVWRCYKYIKAMNSGGVKVDS--KLLQKVVLPSYEEALSL 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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