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Conserved domains on  [gi|966978527|ref|XP_014966599|]
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solute carrier family 23 member 3 isoform X4 [Macaca mulatta]

Protein Classification

permease family protein( domain architecture ID 581063)

permease family protein, similar to Saccharomyces cerevisiae boron transporter 1 which functions in boric acid/borate export across the plasma membrane thereby protects yeast cells from boron toxicity and is involved in the trafficking of proteins to the vacuole

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Xan_ur_permease super family cl23746
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
77-356 1.12e-34

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


The actual alignment was detected with superfamily member pfam00860:

Pssm-ID: 474042 [Multi-domain]  Cd Length: 389  Bit Score: 133.96  E-value: 1.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527   77 GGLSYSPSQLLASSFFSCGVSTILQTWMGSRL--PLVQAPSLEFLISALVLTSQKLPLAIQTPGNSSLMMHLCRGPS-CH 153
Cdd:pfam00860   1 GQLLLLGLQHLLAMFAATIVVPLLVGDALGLGaeDLAQLISATFLASGIGTLLQTLIFGIRLPIYLGSSFAFVTALMiAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  154 GLRHWNTSLQEVSGAVVVSGLLQGTMGLLGSPGRVFPHCGPLVLAPSLVVAGLSAHREVAQFCSAHW------------- 220
Cdd:pfam00860  81 GLADWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVLLIGLSLAPIAVKGAGGGWaiadgltvglldl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  221 -GLALLT---------------------------WAPASFMCAPGGELQLHQLTLLSLPSGSSR---------------- 256
Cdd:pfam00860 161 lGLAVVVlavilllsvflkgffrqgpiligiiagWLLALFMGIVNFSPEVMDAPWFQLPHPFPFgtplfnpgliltmlav 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  257 -------------------NCLPPPRHR--------GFGCL----------------------TQAGSQQVAHLVGLLCM 287
Cdd:pfam00860 241 alvaivestgdiravakvsGRDLKPKPDlrrglladGLATLlsglfgafptttyaenigvvalTKVYSRRVGVTAGVILI 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966978527  288 GLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFRE 356
Cdd:pfam00860 321 LLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGISTVPEL 389
 
Name Accession Description Interval E-value
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
77-356 1.12e-34

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 133.96  E-value: 1.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527   77 GGLSYSPSQLLASSFFSCGVSTILQTWMGSRL--PLVQAPSLEFLISALVLTSQKLPLAIQTPGNSSLMMHLCRGPS-CH 153
Cdd:pfam00860   1 GQLLLLGLQHLLAMFAATIVVPLLVGDALGLGaeDLAQLISATFLASGIGTLLQTLIFGIRLPIYLGSSFAFVTALMiAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  154 GLRHWNTSLQEVSGAVVVSGLLQGTMGLLGSPGRVFPHCGPLVLAPSLVVAGLSAHREVAQFCSAHW------------- 220
Cdd:pfam00860  81 GLADWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVLLIGLSLAPIAVKGAGGGWaiadgltvglldl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  221 -GLALLT---------------------------WAPASFMCAPGGELQLHQLTLLSLPSGSSR---------------- 256
Cdd:pfam00860 161 lGLAVVVlavilllsvflkgffrqgpiligiiagWLLALFMGIVNFSPEVMDAPWFQLPHPFPFgtplfnpgliltmlav 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  257 -------------------NCLPPPRHR--------GFGCL----------------------TQAGSQQVAHLVGLLCM 287
Cdd:pfam00860 241 alvaivestgdiravakvsGRDLKPKPDlrrglladGLATLlsglfgafptttyaenigvvalTKVYSRRVGVTAGVILI 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966978527  288 GLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFRE 356
Cdd:pfam00860 321 LLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGISTVPEL 389
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
43-401 2.44e-16

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 80.94  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  43 LPWGLSCLLALQHVLVM--ASLLCVSHLLLLCSLSPGGLSYSPSqllaSSFFSCGVSTILQTW-MGSRLPLVQAPSLEFL 119
Cdd:COG2233   17 PPLGQTLLLGLQHVLAMfgATVLVPLIVGGALGLSAAQTALLIS----AALFVSGIGTLLQLLgTGGRLPIVLGSSFAFI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 120 ISALVLTSQklplaiqtpgnsslmmhlcrgpschglrhwnTSLQEVSGAVVVSGLLQGTMGLLGSP-GRVFPhcgPLVLA 198
Cdd:COG2233   93 APIIAIGAA-------------------------------YGLAAALGGIIVAGLVYILLGLLIKRiRRLFP---PVVTG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 199 PSLVVAGLS----------AHREVAQFCS-AHWGLALLT--------------WAPASFM---------CAPGGELQLHQ 244
Cdd:COG2233  139 TVVMLIGLSlapvainmaaGGPGAPDFGSpQNLLLALVTlavilllsvfgkgfLRRISILigivvgyivALLLGMVDFSP 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 245 LT---LLSLPS-------------------------------------GSSRNCLPPPRHRG-------------FGC-- 269
Cdd:COG2233  219 VAeapWFALPTpfpfglptfdlgailtmlpvalvtiaetigdilavgeITGRDITDPRLGRGllgdglatmlaglFGGfp 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 270 ------------LTQAGSQQVAHLVGLLCMGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNI 337
Cdd:COG2233  299 nttysenigviaLTGVYSRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNL 378
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966978527 338 FIVGFSIFMALLLPRwfreAPVLFSTgwspLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLER 401
Cdd:COG2233  379 LIVAVSLGLGLGVTG----VPGALAT----LPATLGPLFLSGIALGALVAILLNLLLPGKKEEE 434
 
Name Accession Description Interval E-value
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
77-356 1.12e-34

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 133.96  E-value: 1.12e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527   77 GGLSYSPSQLLASSFFSCGVSTILQTWMGSRL--PLVQAPSLEFLISALVLTSQKLPLAIQTPGNSSLMMHLCRGPS-CH 153
Cdd:pfam00860   1 GQLLLLGLQHLLAMFAATIVVPLLVGDALGLGaeDLAQLISATFLASGIGTLLQTLIFGIRLPIYLGSSFAFVTALMiAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  154 GLRHWNTSLQEVSGAVVVSGLLQGTMGLLGSPGRVFPHCGPLVLAPSLVVAGLSAHREVAQFCSAHW------------- 220
Cdd:pfam00860  81 GLADWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVLLIGLSLAPIAVKGAGGGWaiadgltvglldl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  221 -GLALLT---------------------------WAPASFMCAPGGELQLHQLTLLSLPSGSSR---------------- 256
Cdd:pfam00860 161 lGLAVVVlavilllsvflkgffrqgpiligiiagWLLALFMGIVNFSPEVMDAPWFQLPHPFPFgtplfnpgliltmlav 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  257 -------------------NCLPPPRHR--------GFGCL----------------------TQAGSQQVAHLVGLLCM 287
Cdd:pfam00860 241 alvaivestgdiravakvsGRDLKPKPDlrrglladGLATLlsglfgafptttyaenigvvalTKVYSRRVGVTAGVILI 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966978527  288 GLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFRE 356
Cdd:pfam00860 321 LLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDLDSARNLLIIAVSLVLGLGISTVPEL 389
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
43-401 2.44e-16

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 80.94  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527  43 LPWGLSCLLALQHVLVM--ASLLCVSHLLLLCSLSPGGLSYSPSqllaSSFFSCGVSTILQTW-MGSRLPLVQAPSLEFL 119
Cdd:COG2233   17 PPLGQTLLLGLQHVLAMfgATVLVPLIVGGALGLSAAQTALLIS----AALFVSGIGTLLQLLgTGGRLPIVLGSSFAFI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 120 ISALVLTSQklplaiqtpgnsslmmhlcrgpschglrhwnTSLQEVSGAVVVSGLLQGTMGLLGSP-GRVFPhcgPLVLA 198
Cdd:COG2233   93 APIIAIGAA-------------------------------YGLAAALGGIIVAGLVYILLGLLIKRiRRLFP---PVVTG 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 199 PSLVVAGLS----------AHREVAQFCS-AHWGLALLT--------------WAPASFM---------CAPGGELQLHQ 244
Cdd:COG2233  139 TVVMLIGLSlapvainmaaGGPGAPDFGSpQNLLLALVTlavilllsvfgkgfLRRISILigivvgyivALLLGMVDFSP 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 245 LT---LLSLPS-------------------------------------GSSRNCLPPPRHRG-------------FGC-- 269
Cdd:COG2233  219 VAeapWFALPTpfpfglptfdlgailtmlpvalvtiaetigdilavgeITGRDITDPRLGRGllgdglatmlaglFGGfp 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966978527 270 ------------LTQAGSQQVAHLVGLLCMGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNI 337
Cdd:COG2233  299 nttysenigviaLTGVYSRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPRNL 378
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966978527 338 FIVGFSIFMALLLPRwfreAPVLFSTgwspLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLER 401
Cdd:COG2233  379 LIVAVSLGLGLGVTG----VPGALAT----LPATLGPLFLSGIALGALVAILLNLLLPGKKEEE 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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