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Conserved domains on  [gi|1622849335|ref|XP_014965319|]
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AMMECR1-like protein isoform X4 [Macaca mulatta]

Protein Classification

AMMECR1 domain-containing protein( domain architecture ID 10486934)

AMMECR1 domain-containing protein such as human nuclear protein AMMECR1 that is implicated in the AMME complex, an X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, intellectual disability, midface hypoplasia, and elliptocytosis

PubMed:  10049589|17715145

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 137-242 5.43e-41

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


:

Pssm-ID: 460368  Cd Length: 167  Bit Score: 139.12  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGvKRTATYLPEVAKEQDWDQIQTIDSLL 216
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 1622849335 217 RKGGFKApiTSEFRKTIKLTRYRSEK 242
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 137-242 5.43e-41

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 139.12  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGvKRTATYLPEVAKEQDWDQIQTIDSLL 216
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 1622849335 217 RKGGFKApiTSEFRKTIKLTRYRSEK 242
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
137-242 3.09e-21

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 87.87  E-value: 3.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYL-DWEVGVHGIRIefinEKGVKRtATYLPEVAKEQDWDQIQTIDSL 215
Cdd:COG2078    79 AFEDPRFPPVTPEELDDLTIEVSVLSPPEPIEDLLeELEPGRDGLIV----EKGGRR-GLLLPQVAWEGLWDPEEFLAHL 153

                          90       100
                  ....*....|....*....|....*..
gi 1622849335 216 LRKGGFkaPITSEFRKTIKLTRYRSEK 242
Cdd:COG2078   154 CRKAGL--PPDAWKDPDVKVYRFEVEV 178
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
 137-221 5.73e-16

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 74.47  E-value: 5.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFE-----DASDYL-DWEVGVHGIRIEFinekGVKRtATYLPEVAKEQDWDQIQ 210
Cdd:TIGR00296  83 ATEDPRFPPVQLEELDDIKVEVSILTPPEtifvgGPKDYPfDIEIGRHGLIVEF----GPKR-GLLLPQVAVEYGWDAEE 157

                          90
                  ....*....|.
gi 1622849335 211 TIDSLLRKGGF 221
Cdd:TIGR00296 158 FLANLCMKAGL 168
PRK00801 PRK00801
hypothetical protein; Provisional
 122-210 1.21e-06

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 48.13  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 122 GFPQP--RLPRFTNDPY---ALKDSRFPPLTREELPKLFCSVSLLTNFE--DAS-----DYLdwEVGVHGIriefINEKG 189
Cdd:PRK00801   61 GFPYPdsPLVEAIIDSAisaATRDPRFPPVKLEEMDEITVEVTVLTPPEliEGPpeelpEKI--EVGRHGL----IVKKG 134

                          90       100
                  ....*....|....*....|.
gi 1622849335 190 VkRTATYLPEVAKEQDWDQIQ 210
Cdd:PRK00801  135 I-YSGLLLPQVAPEWGFDSEE 154
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
 137-242 5.43e-41

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 139.12  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYLDWEVGVHGIRIefinEKGvKRTATYLPEVAKEQDWDQIQTIDSLL 216
Cdd:pfam01871  68 AFRDPRFPPLTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLII----EKG-GRSGTLLPQVAVEQGWDPEEFLDHLC 142

                          90       100
                  ....*....|....*....|....*.
gi 1622849335 217 RKGGFKApiTSEFRKTIKLTRYRSEK 242
Cdd:pfam01871 143 RKAGLPP--DAWRDEDVKLYRFEAEV 166
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
137-242 3.09e-21

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 87.87  E-value: 3.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFEDASDYL-DWEVGVHGIRIefinEKGVKRtATYLPEVAKEQDWDQIQTIDSL 215
Cdd:COG2078    79 AFEDPRFPPVTPEELDDLTIEVSVLSPPEPIEDLLeELEPGRDGLIV----EKGGRR-GLLLPQVAWEGLWDPEEFLAHL 153

                          90       100
                  ....*....|....*....|....*..
gi 1622849335 216 LRKGGFkaPITSEFRKTIKLTRYRSEK 242
Cdd:COG2078   154 CRKAGL--PPDAWKDPDVKVYRFEVEV 178
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
 137-221 5.73e-16

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 74.47  E-value: 5.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 137 ALKDSRFPPLTREELPKLFCSVSLLTNFE-----DASDYL-DWEVGVHGIRIEFinekGVKRtATYLPEVAKEQDWDQIQ 210
Cdd:TIGR00296  83 ATEDPRFPPVQLEELDDIKVEVSILTPPEtifvgGPKDYPfDIEIGRHGLIVEF----GPKR-GLLLPQVAVEYGWDAEE 157

                          90
                  ....*....|.
gi 1622849335 211 TIDSLLRKGGF 221
Cdd:TIGR00296 158 FLANLCMKAGL 168
PRK00801 PRK00801
hypothetical protein; Provisional
 122-210 1.21e-06

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 48.13  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622849335 122 GFPQP--RLPRFTNDPY---ALKDSRFPPLTREELPKLFCSVSLLTNFE--DAS-----DYLdwEVGVHGIriefINEKG 189
Cdd:PRK00801   61 GFPYPdsPLVEAIIDSAisaATRDPRFPPVKLEEMDEITVEVTVLTPPEliEGPpeelpEKI--EVGRHGL----IVKKG 134

                          90       100
                  ....*....|....*....|.
gi 1622849335 190 VkRTATYLPEVAKEQDWDQIQ 210
Cdd:PRK00801  135 I-YSGLLLPQVAPEWGFDSEE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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