NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767969579|ref|XP_011540899|]
View 

NXPE family member 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Neurexophilin super family cl05683
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 131-265 7.00e-16

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


The actual alignment was detected with superfamily member pfam06312:

Pssm-ID: 428882  Cd Length: 209  Bit Score: 76.44  E-value: 7.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969579  131 RKQYG-GDFlRARMSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKG 207
Cdd:pfam06312  54 KKKFGwGDF-YSNIKTVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNC 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767969579  208 KFVNGTSHVFTECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 265
Cdd:pfam06312 133 RVESEKVDRTTKTNLCNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 131-265 7.00e-16

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 76.44  E-value: 7.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969579  131 RKQYG-GDFlRARMSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKG 207
Cdd:pfam06312  54 KKKFGwGDF-YSNIKTVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNC 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767969579  208 KFVNGTSHVFTECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 265
Cdd:pfam06312 133 RVESEKVDRTTKTNLCNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Name Accession Description Interval E-value
Neurexophilin pfam06312
Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains ...
 131-265 7.00e-16

Neurexophilin; This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.


Pssm-ID: 428882  Cd Length: 209  Bit Score: 76.44  E-value: 7.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969579  131 RKQYG-GDFlRARMSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARN--QGYDKIIFKG 207
Cdd:pfam06312  54 KKKFGwGDF-YSNIKTVKLNLLITGKIVDHGNGTFSVFFRHNSTGQGNVSVSLVPPSKAVEFDLEQQYviEAKDSKIFNC 132

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767969579  208 KFVNGTSHVFTECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREV 265
Cdd:pfam06312 133 RVESEKVDRTTKTNLCNYDPSKTCNQEHTQSHVSWFCSKPFKVICIYISFYSTDYRLV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH