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Conserved domains on  [gi|767905262|ref|XP_011540137|]
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protein dispatched homolog 3 isoform X9 [Homo sapiens]

Protein Classification

RND transporter family protein( domain architecture ID 1001856)

resistance-nodulation-cell division (RND) transporter family protein

Gene Ontology:  GO:0016020|GO:0055085
PubMed:  10941792
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MMPL super family cl34072
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 2.31e-27

Predicted exporter protein, RND superfamily [General function prediction only];


The actual alignment was detected with superfamily member COG1033:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.81  E-value: 2.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033  188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033  266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                        170       180
                 ....*....|....*....|....*...
gi 767905262 589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033  345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 2.31e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.81  E-value: 2.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033  188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033  266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                        170       180
                 ....*....|....*....|....*...
gi 767905262 589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033  345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 485-615 1.99e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 68.38  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349   6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767905262  563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349  83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 441-615 6.02e-11

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 66.01  E-value: 6.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704

                         170
                  ....*....|....*
gi 767905262  601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
431-616 2.31e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 118.81  E-value: 2.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 431 AMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVAL-FLYhvV 509
Cdd:COG1033  188 AIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--L 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 510 FGIQyLGILNGVAAFVIVGIGVDDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVH 588
Cdd:COG1033  266 LGIP-LSPLTILVPPLLLAIGIDYGIHLLNRYREERrKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIR 344

                        170       180
                 ....*....|....*....|....*...
gi 767905262 589 DFGLFMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:COG1033  345 DFGIVAAIGVLLAFLTSLTLLPALLSLL 372
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
386-616 4.90e-19

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 92.23  E-value: 4.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 386 SADNLKSSLLRSEILFGAPLPNYYSVD---------------DRWEEQRAKFQSFVVTYVAmlakqsTSKVQVLYGGTDL 450
Cdd:COG1033  521 SRELLAQLLLLLSSPPGDDLSRFVDEDysaarvtvrlkdldsEEIKALVEEVRAFLAENFP------PDGVEVTLTGSAV 594

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 451 FDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLScLVALFLYHVVFGIQyLGILNGVAAFVIVGIG 530
Cdd:COG1033  595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLP-ILLTFGLMGLLGIP-LNIATAVVASIALGIG 672

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 531 VDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTM 609
Cdd:COG1033  673 VDYTIHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752


                 ....*..
gi 767905262 610 PAALGLW 616
Cdd:COG1033  753 PALLLLL 759
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 485-615 1.99e-13

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 68.38  E-value: 1.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  485 VFLSFFGIASIGLS--CLVALFLYhvvFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAG 562
Cdd:pfam12349   6 FGLGLAGVIIVLASvaSSLGLCAY---FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767905262  563 KATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam12349  83 PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 412-613 2.56e-12

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 70.46  E-value: 2.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  412 DDRWEEQRAKFqsFVVTYVAMLAKQSTSK-VQVLYGGTDLFDYEVRRtfNNDMLLAFISSSCIAALVYILTSCSVFLSFF 490
Cdd:pfam02460 166 DEEEVEEDSKE--WEDELSQLLHNKYASEhIQFTIFHDQILNDELVR--NALTLTPFFVIGFFLLLTFSIIVSVTLSSYT 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  491 -------------GIASIGLSCLVAL-FLYhvVFGIQYLGILNgVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIH 556
Cdd:pfam02460 242 idwvrskpilaalGLLSPVMAIVSSFgLLF--WMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGE 318

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767905262  557 TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLvTMPAAL 613
Cdd:pfam02460 319 ALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQI-TFFAAI 374
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 441-615 6.02e-11

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 66.01  E-value: 6.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALfLYHVVFGIQYLGILNG 520
Cdd:TIGR00921 547 VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAI-GLMGLRGIPSFLAMAT 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  521 VAAfVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSC 600
Cdd:TIGR00921 626 TIS-IILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLS 704

                         170
                  ....*....|....*
gi 767905262  601 CWLAVLVTMPAALGL 615
Cdd:TIGR00921 705 SLTAALVVFPALLVL 719
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
407-615 3.39e-10

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 63.75  E-value: 3.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262   407 NYYSVDDRWEEQRAKF------QSFVVTYVAMLAKQSTSKVQVlYGGTDLfdyevrrtfnNDMLLAFISSSCI----AAL 476
Cdd:TIGR00918  339 YYKVHHIGWNEEKAAAvleawqRNFSEEVQQSLPKNSSQKILV-FSSTTL----------DDILKKFSDVSAIrivsGYL 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262   477 VYILTSCSVFL--------SFFGIASIGLSCL-VALFL-YHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATH 546
Cdd:TIGR00918  408 LMLAYACLTMLrwdcaksqGSVGLAGVLLVALsVAAGLgLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ 487

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767905262   547 LEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00918  488 NIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 426-615 4.45e-10

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 61.92  E-value: 4.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  426 VVTYVAMLAKQSTSKVQVlyGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSC-----L 500
Cdd:pfam03176 109 VRDAVEQAPPPEGLKAYL--TGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  501 VALFLYHVVFGIQYLGIlnGVAAFVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAAN 579
Cdd:pfam03176 187 VAILAHILGIGLSTFAL--NLLVVLLIAVGTDYALFLVSRYREELRAgEDREEAVIRAVRGTGKVVTAAGLTVAIAMLAL 264

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 767905262  580 VFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:pfam03176 265 SFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 440-613 1.16e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 61.78  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  440 KVQVLYGGTDLfDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIAsiglsclVALFLYHVVFGIQ-YLGI- 517
Cdd:TIGR00921 173 KFLDVTGSPAI-NYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLV-------IILFGVAWVLGIMgWLGIp 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  518 ----LNGVAAfVIVGIGVDDVFVFINTYRQATHL-EDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00921 245 lyatTLLAVP-MLIGVGIDYGIQTLNRYEEERDIgRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGL 323

                         170       180
                  ....*....|....*....|.
gi 767905262  593 FMSLIVSCCWLAVLVTMPAAL 613
Cdd:TIGR00921 324 GLVAGLITAYLLTLLVLPALL 344
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 433-615 5.21e-09

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 59.78  E-value: 5.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 433 LAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFF----GIASIGLSCLVALFLYHV 508
Cdd:COG2409  141 VAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLplltAGLAVGVALGLLALLAAF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 509 V-FGIQYLGIlngvaAFVIV-GIGVDDVFVFINTYRQA-THLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIP 585
Cdd:COG2409  221 TdVSSFAPNL-----LTMLGlGVGIDYALFLVSRYREElRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLP 295

                        170       180       190
                 ....*....|....*....|....*....|
gi 767905262 586 AVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
Cdd:COG2409  296 FLRSMGPAAAIGVAVAVLAALTLLPALLAL 325
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 375-615 2.41e-07

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 54.53  E-value: 2.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262   375 PEFYWYVDEGLSADNLKSSllrSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQvlYGGTDLFDYE 454
Cdd:TIGR00917  491 PVDPTTVLGGFSGNNFSEA---SAFVVTFPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMVQATIS--FSAERSIEDE 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262   455 VRRTFNNDM---------LLAFISSSC--IAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVfGIQYLGILNGVAA 523
Cdd:TIGR00917  566 LKRESTADVitiaisylvMFAYISLTLgdSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAV-GLKSTLIIMEVIP 644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262   524 FVIVGIGVDDVFVFINTY------RQATHLEDPQL-----RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR00917  645 FLVLAVGVDNIFILVFFYfyleyfYRQVGVDNEQEltlerRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSM 724

                          250       260
                   ....*....|....*....|...
gi 767905262   593 FMSLIVSCCWLAVLVTMPAALGL 615
Cdd:TIGR00917  725 FAVLAVFLDFLLQITAFVALLVL 747
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 449-614 2.59e-07

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 54.23  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  449 DLFDYEVRRTFNNDMLLafISSSCIAALVYILTSCSV----FLSFFGIASIGLSCL----------VALFLYHVVFGIQY 514
Cdd:TIGR03480 675 DLNDNEALRRFVRAVRK--VAPDATGAPVSILESGDTvvgaFLQAFIYALVAITVLllltlrrvrdVLLVLAPLLLAGLL 752

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  515 LGIL-----------NGVAAFVIVGIGVDDVFVFINTYRQATHLEDPqlrmIHTvqTAGKATFFTSLTTAAAYAANVFSQ 583
Cdd:TIGR03480 753 TVAAmvllgipfnfaNIIALPLLLGLGVDFGIYMVHRWRNGVDSGNL----LQS--STARAVFFSALTTATAFGSLAVSS 826

                         170       180       190
                  ....*....|....*....|....*....|.
gi 767905262  584 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALG 614
Cdd:TIGR03480 827 HPGTASMGILLSLGLGLTLLCTLIFLPALLG 857
COG4258 COG4258
Predicted exporter [General function prediction only];
434-612 2.22e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 51.39  E-value: 2.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 434 AKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGiq 513
Cdd:COG4258  222 LNAAFPGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAVSLVFG-- 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 514 YLGILNGVAAFVIVGIGVDDVFVFInTYRQATHLEDPQlrmiHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLF 593
Cdd:COG4258  300 SVHGITLGFGSSLIGVAVDYSLHYL-THRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVF 374

                        170       180
                 ....*....|....*....|....*
gi 767905262 594 --MSLIVSC----CWLAVLVTMPAA 612
Cdd:COG4258  375 aaAGLLAAAlttlLWLPLLLPRAAP 399
COG4258 COG4258
Predicted exporter [General function prediction only];
474-611 7.51e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 42.92  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262 474 AALVYILTSCSVFLSFFGI-------ASIGLSCLVALFLYhVVFGIQyLGILNGVAAFVIVGIGVD-DVFVfintyRQAT 545
Cdd:COG4258  645 LLLALLLILLLLLLRLRSLrralrvlLPPLLAVLLTLAIL-GLLGIP-LNLFHLIALLLVLGIGIDyALFF-----TEGL 717

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767905262 546 HLEDPQLRMIHTVqtagkatFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPA 611
Cdd:COG4258  718 LDKGELARTLLSI-------LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 437-616 1.14e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 42.68  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  437 STSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTscsvFLSFFGIASIgLSCLVALFLYHVVFGIQYLG 516
Cdd:TIGR03480 245 EDHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLA----LRSPRLVFAV-LVTLIVGLILTAAFATLAVG 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  517 ILNGVA-AFVI--VGIGVDDVFVFINTYRQATHLEDPQLRMIH-TVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGL 592
Cdd:TIGR03480 320 HLNLISvAFAVlfIGLGVDFAIQFSLRYREERFRGGNHREALSvAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGI 399

                         170       180
                  ....*....|....*....|....
gi 767905262  593 FMSLIVSCCWLAVLVTMPAALGLW 616
Cdd:TIGR03480 400 IAGTGMFIALFVTLTVLPALLRLL 423
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 459-617 4.65e-03

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 40.72  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  459 FNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALflyHVVFGIQYLGILnGVAAF-------VIVGIGV 531
Cdd:TIGR00833 171 GDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQ---GIVSLLGIPGLI-GVNAQttvlltaLVIGAGT 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905262  532 DDVFVFINTYRQAT-HLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMP 610
Cdd:TIGR00833 247 DYAVFLTGRYHEERrKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTP 326


                  ....*..
gi 767905262  611 AALGLWS 617
Cdd:TIGR00833 327 ALLTLEG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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