|
Name |
Accession |
Description |
Interval |
E-value |
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
386-699 |
1.63e-71 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 240.18 E-value: 1.63e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 386 PTEAGRLMAWYYITFETVKKFYT-ISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKdpnriTIRFPMEGRIKTR 464
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNQsLKPNTTLADLLRILSSASEFEQIPVRQEEKKELKKLLE-----KVPIPVKGDIEDP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 465 EMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDfVAAQEKKFAVLLNSLILAKCFRCKLWeNSLHVSKQLE 544
Cdd:pfam02889 76 HAKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFE-ILLSKGWLSAALTALDLCKMIEQRMW-DSDSPLRQFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 545 KIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEqITRYSDTTAEILVTVIlRNFE 624
Cdd:pfam02889 154 GIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVNRFPKIEIEAE-VQPITRSVLRVEVTIT-PDFP 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902776 625 qlQTKRTASDSHYVTLIIGDADNQVVYLHKITdSVLLKAGSWAKKIAVKRALKSE---DLSINLISSEFVGLDIQQKL 699
Cdd:pfam02889 232 --WDKRVHGKSEGFWLVVGDSDGNEILHIERF-TLTKRTLAGEHKLEFTVPPSDPgppQLFVRLISDSWLGADQEVPI 306
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
14-407 |
2.23e-68 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 238.64 E-value: 2.23e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 14 VRLFLIDEVHIVKDENRGPTLEVVVSRMKTVqsvsqtlkntstAIPMRFVAVSATIPNAEDIAEWLsdgERPAVclkmDE 93
Cdd:COG1204 138 VDLVVVDEAHLIDDESRGPTLEVLLARLRRL------------NPEAQIVALSATIGNAEEIAEWL---DAELV----KS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 94 SHRPVKLQKVVLgfpcSSNQTEF--KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQR 171
Cdd:COG1204 199 DWRPVPLNEGVL----YDGVLRFddGSRRSKDPTLALALDLLEEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 172 LQKYAYSVR--------DSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTmH 243
Cdd:COG1204 275 LEELAEELLevseethtNEKLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT-K 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 244 YAGGlfEEYSETDILQMIGRAGRPQFDTTATAVIMTR-LSTRDKYIQMLACRDT--VESSLH--RHLIEHLNAEIVLHTI 318
Cdd:COG1204 354 RGGM--VPIPVLEFKQMAGRAGRPGYDPYGEAILVAKsSDEADELFERYILGEPepIRSKLAneSALRTHLLALIASGFA 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 319 TDVNIAVEWIRSTLLYIRAlknpshygfasglNKDGIEAKLQElclkNLNDLSSLDLIKMDEGvNFKPTEAGRLMAWYYI 398
Cdd:COG1204 432 NSREELLDFLENTFYAYQY-------------DKGDLEEVVDD----ALEFLLENGFIEEDGD-RLRATKLGKLVSRLYI 493
|
....*....
gi 767902776 399 TFETVKKFY 407
Cdd:COG1204 494 DPLTAAELV 502
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
386-701 |
4.67e-63 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 216.84 E-value: 4.67e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 386 PTEAGRLMAWYYITFETVKKFYT-ISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDpnritIRFPMEGRIKTR 464
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQsLKPTTTLKDILEILSRASEFKEIPVRHNEKKELNELNKR-----VPIPVKEGIIDS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 465 EM-KVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDfVAAQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQL 543
Cdd:smart00973 76 PHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVD-IALSKGWLRTALNALDLSQMVVQRLWEDSDSPLKQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 544 EKIGI--TLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTaeILVTVILR 621
Cdd:smart00973 155 PHFLIedVYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYELLRRFPKIEVEAEVLPITRDLT--LRVELEIT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 622 NFEQLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAK-KIAVKR-ALKSEDLSINLISSEFVGLDIQQKL 699
Cdd:smart00973 233 PVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKKSNEVKlDFTVPLsEPGPENYTVYLISDSYLGCDQEVSF 312
|
..
gi 767902776 700 TV 701
Cdd:smart00973 313 SL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
96-280 |
1.81e-59 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 200.47 E-value: 1.81e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 96 RPVKLQKVVLGFPCSSNQTEFKFDLT--LNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVkdakfimtveqkqrlq 173
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKfdSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA---------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 174 kyaysvrdsklrdilkdGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYS 253
Cdd:cd18795 65 -----------------GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELS 127
|
170 180
....*....|....*....|....*..
gi 767902776 254 ETDILQMIGRAGRPQFDTTATAVIMTR 280
Cdd:cd18795 128 PLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
19-278 |
3.11e-38 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 153.57 E-value: 3.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 19 IDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTlkntstaipmrfVAVSATIPNAEDIAEWLsDGERpavclkMDESHRPV 98
Cdd:PRK02362 143 VDEVHLIDSANRGPTLEVTLAKLRRLNPDLQV------------VALSATIGNADELADWL-DAEL------VDSEWRPI 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 99 KLQKVVL---GFPCSSNQTEFKF---DLTLNYkiasVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRL 172
Cdd:PRK02362 204 DLREGVFyggAIHFDDSQREVEVpskDDTLNL----VLDTLEEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAEL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 173 QKYAYSVRDS-------KLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYA 245
Cdd:PRK02362 280 AELAEEIREVsdtetskDLADCVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYD 359
|
250 260 270
....*....|....*....|....*....|....*....
gi 767902776 246 GGL------FEEYSetdilQMIGRAGRPQFDTTATAVIM 278
Cdd:PRK02362 360 GGAgmqpipVLEYH-----QMAGRAGRPGLDPYGEAVLL 393
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
188-267 |
2.08e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.77 E-value: 2.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 188 LKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLP-AHLVVIKSTmhyagglfeEYSETDILQMIGRAGR 266
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGR 80
|
.
gi 767902776 267 P 267
Cdd:smart00490 81 A 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
125-266 |
2.77e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 55.68 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 125 KIASVIQMYSDQKP--TLVFCATRKGVqqaasvlvkDAKFImtveqkqrLQKYAYSVrdsklrdilkdgaAYHHAGMELS 202
Cdd:pfam00271 2 KLEALLELLKKERGgkVLIFSQTKKTL---------EAELL--------LEKEGIKV-------------ARLHGDLSQE 51
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902776 203 DRKVVEGAFTVGDLPVLFTTSTLAMGVNLP-AHLVVIkstmhyagglFE-EYSETDILQMIGRAGR 266
Cdd:pfam00271 52 EREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN----------YDlPWNPASYIQRIGRAGR 107
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
386-699 |
1.63e-71 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 240.18 E-value: 1.63e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 386 PTEAGRLMAWYYITFETVKKFYT-ISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKdpnriTIRFPMEGRIKTR 464
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNQsLKPNTTLADLLRILSSASEFEQIPVRQEEKKELKKLLE-----KVPIPVKGDIEDP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 465 EMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDfVAAQEKKFAVLLNSLILAKCFRCKLWeNSLHVSKQLE 544
Cdd:pfam02889 76 HAKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFE-ILLSKGWLSAALTALDLCKMIEQRMW-DSDSPLRQFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 545 KIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEqITRYSDTTAEILVTVIlRNFE 624
Cdd:pfam02889 154 GIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVNRFPKIEIEAE-VQPITRSVLRVEVTIT-PDFP 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902776 625 qlQTKRTASDSHYVTLIIGDADNQVVYLHKITdSVLLKAGSWAKKIAVKRALKSE---DLSINLISSEFVGLDIQQKL 699
Cdd:pfam02889 232 --WDKRVHGKSEGFWLVVGDSDGNEILHIERF-TLTKRTLAGEHKLEFTVPPSDPgppQLFVRLISDSWLGADQEVPI 306
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
14-407 |
2.23e-68 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 238.64 E-value: 2.23e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 14 VRLFLIDEVHIVKDENRGPTLEVVVSRMKTVqsvsqtlkntstAIPMRFVAVSATIPNAEDIAEWLsdgERPAVclkmDE 93
Cdd:COG1204 138 VDLVVVDEAHLIDDESRGPTLEVLLARLRRL------------NPEAQIVALSATIGNAEEIAEWL---DAELV----KS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 94 SHRPVKLQKVVLgfpcSSNQTEF--KFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQR 171
Cdd:COG1204 199 DWRPVPLNEGVL----YDGVLRFddGSRRSKDPTLALALDLLEEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREE 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 172 LQKYAYSVR--------DSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTmH 243
Cdd:COG1204 275 LEELAEELLevseethtNEKLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT-K 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 244 YAGGlfEEYSETDILQMIGRAGRPQFDTTATAVIMTR-LSTRDKYIQMLACRDT--VESSLH--RHLIEHLNAEIVLHTI 318
Cdd:COG1204 354 RGGM--VPIPVLEFKQMAGRAGRPGYDPYGEAILVAKsSDEADELFERYILGEPepIRSKLAneSALRTHLLALIASGFA 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 319 TDVNIAVEWIRSTLLYIRAlknpshygfasglNKDGIEAKLQElclkNLNDLSSLDLIKMDEGvNFKPTEAGRLMAWYYI 398
Cdd:COG1204 432 NSREELLDFLENTFYAYQY-------------DKGDLEEVVDD----ALEFLLENGFIEEDGD-RLRATKLGKLVSRLYI 493
|
....*....
gi 767902776 399 TFETVKKFY 407
Cdd:COG1204 494 DPLTAAELV 502
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
386-701 |
4.67e-63 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 216.84 E-value: 4.67e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 386 PTEAGRLMAWYYITFETVKKFYT-ISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKDpnritIRFPMEGRIKTR 464
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQsLKPTTTLKDILEILSRASEFKEIPVRHNEKKELNELNKR-----VPIPVKEGIIDS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 465 EM-KVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDfVAAQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQL 543
Cdd:smart00973 76 PHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVD-IALSKGWLRTALNALDLSQMVVQRLWEDSDSPLKQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 544 EKIGI--TLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELKVEQITRYSDTTaeILVTVILR 621
Cdd:smart00973 155 PHFLIedVYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYELLRRFPKIEVEAEVLPITRDLT--LRVELEIT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 622 NFEQLQTKRTASDSHYVTLIIGDADNQVVYLHKITDSVLLKAGSWAK-KIAVKR-ALKSEDLSINLISSEFVGLDIQQKL 699
Cdd:smart00973 233 PVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKKSNEVKlDFTVPLsEPGPENYTVYLISDSYLGCDQEVSF 312
|
..
gi 767902776 700 TV 701
Cdd:smart00973 313 SL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
96-280 |
1.81e-59 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 200.47 E-value: 1.81e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 96 RPVKLQKVVLGFPCSSNQTEFKFDLT--LNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLVkdakfimtveqkqrlq 173
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKfdSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLA---------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 174 kyaysvrdsklrdilkdGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYS 253
Cdd:cd18795 65 -----------------GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELS 127
|
170 180
....*....|....*....|....*..
gi 767902776 254 ETDILQMIGRAGRPQFDTTATAVIMTR 280
Cdd:cd18795 128 PLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
1-97 |
2.00e-44 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 159.83 E-value: 2.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 1 MTRKWRDN-SLVQLVRLFLIDEVHIVKdENRGPTLEVVVSRMKTVQSVSQTlkNTSTAIPMRFVAVSATIPNAEDIAEWL 79
Cdd:cd18023 114 MTRRWRDNgNLVQLVALVLIDEVHIIK-ENRGATLEVVVSRMKTLSSSSEL--RGSTVRPMRFVAVSATIPNIEDLAEWL 190
|
90
....*....|....*...
gi 767902776 80 SDGerPAVCLKMDESHRP 97
Cdd:cd18023 191 GDN--PAGCFSFGESFRP 206
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
19-278 |
3.11e-38 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 153.57 E-value: 3.11e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 19 IDEVHIVKDENRGPTLEVVVSRMKTVQSVSQTlkntstaipmrfVAVSATIPNAEDIAEWLsDGERpavclkMDESHRPV 98
Cdd:PRK02362 143 VDEVHLIDSANRGPTLEVTLAKLRRLNPDLQV------------VALSATIGNADELADWL-DAEL------VDSEWRPI 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 99 KLQKVVL---GFPCSSNQTEFKF---DLTLNYkiasVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRL 172
Cdd:PRK02362 204 DLREGVFyggAIHFDDSQREVEVpskDDTLNL----VLDTLEEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAEL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 173 QKYAYSVRDS-------KLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYA 245
Cdd:PRK02362 280 AELAEEIREVsdtetskDLADCVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYD 359
|
250 260 270
....*....|....*....|....*....|....*....
gi 767902776 246 GGL------FEEYSetdilQMIGRAGRPQFDTTATAVIM 278
Cdd:PRK02362 360 GGAgmqpipVLEYH-----QMAGRAGRPGLDPYGEAVLL 393
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
9-406 |
6.25e-35 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 143.42 E-value: 6.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 9 SLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQSVsqtlkntstaipmrfVAVSATIPNAEDIAEWLSdgerpAVC 88
Cdd:PRK00254 134 SWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQI---------------LGLSATVGNAEELAEWLN-----AEL 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 89 LKMDesHRPVKLQKVV--LGFPCSSNQTEFKFDLTLNykiASVIQMYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTV 166
Cdd:PRK00254 194 VVSD--WRPVKLRKGVfyQGFLFWEDGKIERFPNSWE---SLVYDAVKKGKGALVFVNTRRSAEKEALELAKKIKRFLTK 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 167 EQKQRLQKYAYSVRDS----KLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTM 242
Cdd:PRK00254 269 PELRALKELADSLEENptneKLKKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTK 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 243 HYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVIMTRL----STRDKYI----QMLACRDTVESSLHRHLIehlnAEIV 314
Cdd:PRK00254 349 RYSNFGWEDIPVLEIQQMMGRAGRPKYDEVGEAIIVATTeepsKLMERYIfgkpEKLFSMLSNESAFRSQVL----ALIT 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 315 LHTITDVNIAVEWIRSTlLYIRALKNPSHygfasglnkdgIEAKLQELC---LKNlndlsslDLIKMDEGVNFKPTEAGR 391
Cdd:PRK00254 425 NFGVSNFKELVNFLERT-FYAHQRKDLYS-----------LEEKAKEIVyflLEN-------EFIDIDLEDRFIPLPLGI 485
|
410
....*....|....*
gi 767902776 392 LMAWYYITFETVKKF 406
Cdd:PRK00254 486 RTSQLYIDPLTAKKF 500
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
7-407 |
5.16e-34 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 140.02 E-value: 5.16e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 7 DNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVqsvsqtlkNTSTaipmRFVAVSATIPNAEDIAEWLSdgerpA 86
Cdd:PRK01172 129 DPYIINDVGLIVADEIHIIGDEDRGPTLETVLSSARYV--------NPDA----RILALSATVSNANELAQWLN-----A 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 87 VCLKmdESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQmysDQKPTLVFCATRKGVQQAASVLVK----DAKF 162
Cdd:PRK01172 192 SLIK--SNFRPVPLKLGILYRKRLILDGYERSQVDINSLIKETVN---DGGQVLVFVSSRKNAEDYAEMLIQhfpeFNDF 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 163 IMTVEQKqrlqkyaySVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTM 242
Cdd:PRK01172 267 KVSSENN--------NVYDDSLNEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDIT 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 243 HYAGGLFEEYSETDILQMIGRAGRPQFDTTATAVI-MTRLSTRDKYIQMLACR-DTVESSLHRHLIEHLN--AEIVLHTI 318
Cdd:PRK01172 339 RYGNGGIRYLSNMEIKQMIGRAGRPGYDQYGIGYIyAASPASYDAAKKYLSGEpEPVISYMGSQRKVRFNtlAAISMGLA 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 319 TDVNIAVEWIRSTLLYIRAlknpshygfasglNKDGIEAKLQElclknlndlsSLDLIK----MDEGVNFKPTEAGRLMA 394
Cdd:PRK01172 419 SSMEDLILFYNETLMAIQN-------------GVDEIDYYIES----------SLKFLKengfIKGDVTLRATRLGKLTS 475
|
410
....*....|....*.
gi 767902776 395 WYYITFET---VKKFY 407
Cdd:PRK01172 476 DLYIDPESaliLKSAF 491
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
19-278 |
1.06e-30 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 130.06 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 19 IDEVHIVKDENRGPTLEVVVsrmktvqsvsqtlkntsTAIP--MRFVAVSATIPNAEDIAEWLSD--GErpavCLKMDES 94
Cdd:COG4581 139 MDEFHYLADPDRGWVWEEPI-----------------IHLParVQLVLLSATVGNAEEFAEWLTRvrGE----TAVVVSE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 95 HRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIQM--YSDQKPTLVFCATRKGVQQAASVLVkdAKFIMTVEQKQRL 172
Cdd:COG4581 198 ERPVPLEFHYLVTPRLFPLFRVNPELLRPPSRHEVIEEldRGGLLPAIVFIFSRRGCDEAAQQLL--SARLTTKEERAEI 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 173 QKYA-------YSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYA 245
Cdd:COG4581 276 REAIdefaedfSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFD 355
|
250 260 270
....*....|....*....|....*....|...
gi 767902776 246 GGLFEEYSETDILQMIGRAGRPQFDTTATAVIM 278
Cdd:COG4581 356 GERHRPLTAREFHQIAGRAGRRGIDTEGHVVVL 388
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
1-83 |
6.25e-20 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 88.47 E-value: 6.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 1 MTRKWRDNsLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVQsvsqtlkntstaIPMRFVAVSATIPNAEDIAEWLS 80
Cdd:cd17921 107 LLRNGGER-LIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLRIN------------KNARFVGLSATLPNAEDLAEWLG 173
|
...
gi 767902776 81 DGE 83
Cdd:cd17921 174 VED 176
|
|
| SEC63 |
smart00611 |
Domain of unknown function in Sec63p, Brr2p and other proteins; |
384-654 |
1.44e-17 |
|
Domain of unknown function in Sec63p, Brr2p and other proteins;
Pssm-ID: 214744 Cd Length: 312 Bit Score: 85.00 E-value: 1.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 384 FKPTEAGRLMAWYYITFETVKKFY-TISGKETLSDLVTLIAGCKEFLDIQLRINEKKTLNTLNKdpnRITIRFPMEGrIK 462
Cdd:smart00611 2 IWPTDLGRIASYYYISYTTIRTFNeLLKPKMTTKDLLRILSMSSEFDQIPVRHEEDLLLEELAE---KLPIRLENPS-LD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 463 TREMKVNCLIQAQLGCIPIQDFALTQDTAKIFRHGSRITRWLSDfVAAQEKKFAVLLNSLILAKCFRCKLWEnSLHVSKQ 542
Cdd:smart00611 78 DPHVKANLLLQAHLSRLKLPSFALESDTVYVLQNAGRLLQAMVD-IALERGWLSTALNALNLSQMIIQALWP-TDSPLLQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 543 LEKIGITLSNAIVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYEL--KVEQITRysdTTAEILVTV-- 618
Cdd:smart00611 156 LPHLPEEILKRLEKKKVLSLEDLLELEDEERGELLGLLDAEGERVYKVLSRLPKLNIeiSLEPITR---TVLGVEVTLtv 232
|
250 260 270
....*....|....*....|....*....|....*..
gi 767902776 619 -ILRNFEQLQTkrtasdSHYVTLIIGDADNQVVYLHK 654
Cdd:smart00611 233 dLTWDDEIHGK------QEGWWLVIGDSDGNELLHIE 263
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
3-79 |
9.47e-17 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 79.61 E-value: 9.47e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767902776 3 RKWRDNSLVQLVRLFLIDEVHIVKDENrGPTLEVVVSRMKTVQSvsQTLKntstaiPMRFVAVSATIPNAEDIAEWL 79
Cdd:cd18021 113 RRWKQRKNVQSVELFIADELHLIGGEN-GPVYEVVVSRMRYISS--QLEK------PIRIVGLSSSLANARDVGEWL 180
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
19-269 |
1.38e-16 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 84.94 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 19 IDEVHIVKDENRGPTLEVVVSRMKTVQSVSQtlkntstaipmrFVAVSATIPNAEDIAEWLSdgerpavcLKMDE-SHRP 97
Cdd:COG1202 332 IDEVHMLEDPERGHRLDGLIARLKYYCPGAQ------------WIYLSATVGNPEELAKKLG--------AKLVEyEERP 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 98 VKLQKVVLgFpcssNQTEFKFDLtlnykIASVIQMYSDQKP-------TLVFCATRKgvqqaasvlvkdakfimtveqkq 170
Cdd:COG1202 392 VPLERHLT-F----ADGREKIRI-----INKLVKREFDTKSskgyrgqTIIFTNSRR----------------------- 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 171 rlqkyaysvRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLPAHLVVIKS-TMhyaGGlf 249
Cdd:COG1202 439 ---------RCHEIARALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFDSlAM---GI-- 504
|
250 260
....*....|....*....|
gi 767902776 250 EEYSETDILQMIGRAGRPQF 269
Cdd:COG1202 505 EWLSVQEFHQMLGRAGRPDY 524
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
9-79 |
8.66e-15 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 73.52 E-value: 8.66e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767902776 9 SLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVqsvsqtlkNTSTaipmRFVAVSATIPNAEDIAEWL 79
Cdd:cd18028 111 SWLRDVGVVVVDEIHLISDEERGPTLESIVARLRRL--------NPNT----QIIGLSATIGNPDELAEWL 169
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
2-79 |
1.05e-14 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 74.33 E-value: 1.05e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767902776 2 TRKWRDNSLVQLVRLFLIDEVHIVKDEnRGPTLEVVVSRmkTVQSVSQTLKntstaiPMRFVAVSATIPNAEDIAEWL 79
Cdd:cd18019 134 TRKSGDRTYTQLVRLIIIDEIHLLHDD-RGPVLESIVAR--TIRQIEQTQE------YVRLVGLSATLPNYEDVATFL 202
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
1-79 |
1.68e-14 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 72.79 E-value: 1.68e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902776 1 MTRKWRDNSLVQLVRLFLIDEVHIVKDEnRGPTLEVVVSRMKTVQSVsqtlkntsTAIPMRFVAVSATIPNAEDIAEWL 79
Cdd:cd18022 109 ISRSWQTREYVQQVSLIIIDEIHLLGSD-RGPVLEVIVSRMNYISSQ--------TEKPVRLVGLSTALANAGDLANWL 178
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
188-267 |
2.08e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.77 E-value: 2.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 188 LKDGAAYHHAGMELSDRKVVEGAFTVGDLPVLFTTSTLAMGVNLP-AHLVVIKSTmhyagglfeEYSETDILQMIGRAGR 266
Cdd:smart00490 10 LGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGR 80
|
.
gi 767902776 267 P 267
Cdd:smart00490 81 A 81
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
1-79 |
7.01e-11 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 62.83 E-value: 7.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 1 MTRKWR-DNSLVQLVRLFLIDEVHIVKDEnRGPTLEVVVSR-MKTVQSvSQTLkntstaipMRFVAVSATIPNAEDIAEW 78
Cdd:cd18020 117 VTRKSSgDVALSQLVRLLIIDEVHLLHDD-RGPVIESLVARtLRQVES-TQSM--------IRIVGLSATLPNYLDVADF 186
|
.
gi 767902776 79 L 79
Cdd:cd18020 187 L 187
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
125-266 |
2.77e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 55.68 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 125 KIASVIQMYSDQKP--TLVFCATRKGVqqaasvlvkDAKFImtveqkqrLQKYAYSVrdsklrdilkdgaAYHHAGMELS 202
Cdd:pfam00271 2 KLEALLELLKKERGgkVLIFSQTKKTL---------EAELL--------LEKEGIKV-------------ARLHGDLSQE 51
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902776 203 DRKVVEGAFTVGDLPVLFTTSTLAMGVNLP-AHLVVIkstmhyagglFE-EYSETDILQMIGRAGR 266
Cdd:pfam00271 52 EREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN----------YDlPWNPASYIQRIGRAGR 107
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
61-266 |
9.35e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 56.38 E-value: 9.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 61 RFVAVSATIPNAEDIAEWLSDgeRPAVCLkmDESHRPVKLQKVVLGFPCSSNQTEFKFDLTLNYKIASVIqMYSDQKpTL 140
Cdd:COG1205 219 QFILASATIGNPAEHAERLTG--RPVTVV--DEDGSPRGERTFVLWNPPLVDDGIRRSALAEAARLLADL-VREGLR-TL 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 141 VFCATRKGVQQAASVLvkdakfimtveqKQRLQKYAYSVRdsklrdIlkdgAAYHhAGMELSDRKVVEGAFTVGDLPVLF 220
Cdd:COG1205 293 VFTRSRRGAELLARYA------------RRALREPDLADR------V----AAYR-AGYLPEERREIERGLRSGELLGVV 349
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767902776 221 TTSTLAMGVNLPA-HLVVIkstMHYAGglfeeySETDILQMIGRAGR 266
Cdd:COG1205 350 STNALELGIDIGGlDAVVL---AGYPG------TRASFWQQAGRAGR 387
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
136-266 |
4.84e-07 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 53.61 E-value: 4.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 136 QKPTLVFCATRKGVQQAAsvlvkdakfimtveqkQRLQKYAYSVrdsklrdilkdgAAYHhAGMELSDRKVVEGAFTVGD 215
Cdd:COG0514 230 GGSGIVYCLSRKKVEELA----------------EWLREAGIRA------------AAYH-AGLDAEEREANQDRFLRDE 280
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767902776 216 LPVLFTTSTLAMGVNLP-----AHLVVIKSTmhyagglfEEYsetdiLQMIGRAGR 266
Cdd:COG0514 281 VDVIVATIAFGMGIDKPdvrfvIHYDLPKSI--------EAY-----YQEIGRAGR 323
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
136-266 |
1.09e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 48.74 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 136 QKPTLVFCATRKGVQQAAsvlvkdakfimtveqkQRLQKyaysvrdsklrdiLKDGAAYHHAGMELSDRKVVEGAFTVGD 215
Cdd:cd18794 30 GGSGIIYCLSRKECEQVA----------------ARLQS-------------KGISAAAYHAGLEPSDRRDVQRKWLRDK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 767902776 216 LPVLFTTSTLAMGVNLP-----AHLVVIKSTMHYagglfeeysetdiLQMIGRAGR 266
Cdd:cd18794 81 IQVIVATVAFGMGIDKPdvrfvIHYSLPKSMESY-------------YQESGRAGR 123
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
8-79 |
1.09e-05 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 47.60 E-value: 1.09e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767902776 8 NSLVQLVRLFLI-----DEVHIVKDENRGPTLEVVVSRMktvqsvsqTLKNTSTaipMRFVAVSATIPNAEDIAEWL 79
Cdd:cd18026 126 NSLIEEGRLDELglvvvDELHMLGDGHRGALLELLLTKL--------LYAAQKN---IQIVGMSATLPNLEELASWL 191
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
5-80 |
6.49e-05 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 45.13 E-value: 6.49e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767902776 5 WRDNSLVQLVRLFLIDEVHIVKDENRGPTLEvvvsrmKTVQSVSQTlkntstaipMRFVAVSATIPNAEDIAEWLS 80
Cdd:cd18024 130 YRGSEIMREVAWVIFDEIHYMRDKERGVVWE------ETIILLPDK---------VRYVFLSATIPNARQFAEWIC 190
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
125-267 |
8.12e-05 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 46.56 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 125 KIASVIQMYSDQKPTLVFCATrkgvqqaasvlVKDAKFIMtveqkQRLQKYAYSvrdsklrdilkdgAAYHHAGMELSDR 204
Cdd:COG1061 294 ILRELLREHPDDRKTLVFCSS-----------VDHAEALA-----ELLNEAGIR-------------AAVVTGDTPKKER 344
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767902776 205 KVVEGAFTVGDLPVLFTTSTLAMGVNLPA--HLVVIKSTMhyagglfeeySETDILQMIGRAGRP 267
Cdd:COG1061 345 EEILEAFRDGELRILVTVDVLNEGVDVPRldVAILLRPTG----------SPREFIQRLGRGLRP 399
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
126-266 |
2.68e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 42.25 E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 126 IASVIQMYSDQKPTLVFCATRKGVqqaasvlvkdakfimtveqkqrlQKYAYSVRDskLRDILKDG--AAYHHAGMELSD 203
Cdd:cd18796 28 YAEVIFLLERHKSTLVFTNTRSQA-----------------------ERLAQRLRE--LCPDRVPPdfIALHHGSLSREL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767902776 204 RKVVEGAFTVGDLPVLFTTSTLAMGVNLPA-HLVV-IKSTmhyagglfeeYSETDILQMIGRAGR 266
Cdd:cd18796 83 REEVEAALKRGDLKVVVATSSLELGIDIGDvDLVIqIGSP----------KSVARLLQRLGRSGH 137
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
137-266 |
3.29e-04 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 44.70 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 137 KPTLVFCATRKGVQQAASvlvkdakfimtveqkqRLQKYAYSVrdsklrdilkdgAAYHhAGMELSDRKVVEGAFTVGDL 216
Cdd:PRK11057 237 KSGIIYCNSRAKVEDTAA----------------RLQSRGISA------------AAYH-AGLDNDVRADVQEAFQRDDL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 767902776 217 PVLFTTSTLAMGVNLP-----AHLVVIKSTMHYagglfeeYSETdilqmiGRAGR 266
Cdd:PRK11057 288 QIVVATVAFGMGINKPnvrfvVHFDIPRNIESY-------YQET------GRAGR 329
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
139-266 |
1.20e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 40.32 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767902776 139 TLVFCATRKgvqqAASVLVKDAKfimtveqkQRLQKYAYSVrdSKLrdilkdgAAYHhAGMELSDRKVVEGAFTVGDLPV 218
Cdd:cd18797 38 TIVFCRSRK----LAELLLRYLK--------ARLVEEGPLA--SKV-------ASYR-AGYLAEDRREIEAELFNGELLG 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767902776 219 LFTTSTLAMGVNLPAHLVVIKSTmhYAGGLFEeysetdILQMIGRAGR 266
Cdd:cd18797 96 VVATNALELGIDIGGLDAVVLAG--YPGSLAS------LWQQAGRAGR 135
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
218-266 |
2.64e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 39.08 E-value: 2.64e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767902776 218 VLFTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSETDILQMIGRAGR 266
Cdd:cd18805 73 VLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGR 121
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
1-79 |
6.52e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 38.72 E-value: 6.52e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767902776 1 MTRKwRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSRMKTVqsvsqtlkntsTAIPMRFVAVSATIPNAEDIAEWL 79
Cdd:cd17922 100 LVNK-KLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKL-----------TGRPLRRIGLSATLGNLEEAAAFL 166
|
|
| |
