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Conserved domains on  [gi|767964234|ref|XP_011538641|]
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cadherin-related family member 1 isoform X3 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-423 6.01e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 328 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 406
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964234 407 --KYSVAEVFITLLDVNDH 423
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 439-530 4.53e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 4.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 439 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 517
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 767964234 518 STTALLKIDITDA 530
Cdd:cd11304   83 SSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-319 6.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 6.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 214 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 291
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964234 292 LLAVEVNTPeKFSSTADVVIQLLDTNDN 319
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-200 3.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964234 134 FRLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIVDLNNH 200
Cdd:cd11304   34 YSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG---GGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-423 6.01e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 328 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 406
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964234 407 --KYSVAEVFITLLDVNDH 423
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
328-418 2.00e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234  328 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 404
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 767964234  405 EGKYSVAEVFITLL 418
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 346-425 2.69e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   346 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 422
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 767964234   423 HPP 425
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 439-530 4.53e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 4.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 439 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 517
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 767964234 518 STTALLKIDITDA 530
Cdd:cd11304   83 SSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-319 6.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 6.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 214 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 291
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964234 292 LLAVEVNTPeKFSSTADVVIQLLDTNDN 319
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 446-529 1.40e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   446 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 523
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 767964234   524 KIDITD 529
Cdd:smart00112  70 TITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-200 3.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964234 134 FRLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIVDLNNH 200
Cdd:cd11304   34 YSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG---GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-321 6.01e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 6.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   234 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 311
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 767964234   312 QLLDTNDNVP 321
Cdd:smart00112  72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 134-202 5.90e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 5.90e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964234   134 FRLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIVDLNNHPP 202
Cdd:smart00112  15 YSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
439-528 4.08e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 4.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234  439 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 513
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 767964234  514 SPSFSTTALLKIDIT 528
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 328-423 6.01e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 328 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 406
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 767964234 407 --KYSVAEVFITLLDVNDH 423
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
328-418 2.00e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234  328 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 404
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 767964234  405 EGKYSVAEVFITLL 418
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 346-425 2.69e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 2.69e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   346 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 422
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 767964234   423 HPP 425
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 439-530 4.53e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 4.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 439 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 517
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 767964234 518 STTALLKIDITDA 530
Cdd:cd11304   83 SSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-319 6.80e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 6.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234 214 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 291
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 767964234 292 LLAVEVNTPeKFSSTADVVIQLLDTNDN 319
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 446-529 1.40e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   446 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 523
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 767964234   524 KIDITD 529
Cdd:smart00112  70 TITVLD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 134-200 3.48e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 3.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767964234 134 FRLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIVDLNNH 200
Cdd:cd11304   34 YSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG---GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-321 6.01e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 6.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234   234 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 311
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 767964234   312 QLLDTNDNVP 321
Cdd:smart00112  72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 134-202 5.90e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 5.90e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767964234   134 FRLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIVDLNNHPP 202
Cdd:smart00112  15 YSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
439-528 4.08e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.15  E-value: 4.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767964234  439 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 513
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 767964234  514 SPSFSTTALLKIDIT 528
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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