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Conserved domains on  [gi|767963611|ref|XP_011538398|]
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annexin A8 isoform X1 [Homo sapiens]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 147-211 2.86e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 2.86e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767963611  147 DAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 211
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 218-283 1.08e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 99.08  E-value: 1.08e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  218 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 283
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 378-443 1.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.00  E-value: 1.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  378 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 443
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 302-368 1.80e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.83  E-value: 1.80e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963611  302 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTV 368
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ATXN-1_C super family cl13922
Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 ...
 1-112 3.23e-07

Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 protein.


The actual alignment was detected with superfamily member pfam12547:

Pssm-ID: 463627  Cd Length: 531  Bit Score: 52.51  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963611    1 MKPVHERNQECLPPKKRDLPmtscstnhtSSSDASEwSRGVVVA--GQSQAG------ARVSLGGDGAEAITGLTVDQYG 72
Cdd:pfam12547   1 MKSNQERSNECLPPKKREIP---------ASTLPSE-EKPVVMApaSESQRGenlawlASVAGGQESGGGRTETSSQSDG 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   73 MLYKVAVPPATFSP-------------TGLPSVLQEPDVWSPSRGQPVSLHLP 112
Cdd:pfam12547  71 PQYKPLSTASDYSSpsssrsssslrvvTSLPAVYTSPLSQSGAGGTVQYTQLP 123
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 147-211 2.86e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 2.86e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767963611  147 DAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 211
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 218-283 1.08e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 99.08  E-value: 1.08e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  218 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 283
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 378-443 1.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.00  E-value: 1.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  378 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 443
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
159-211 9.58e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 85.15  E-value: 9.58e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   159 GTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 211
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 302-368 1.80e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.83  E-value: 1.80e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963611  302 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTV 368
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
231-283 1.12e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 79.37  E-value: 1.12e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   231 GTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 283
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
391-443 1.50e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 1.50e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   391 GTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 443
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
316-368 2.06e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 2.06e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   316 GTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTV 368
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ATXN-1_C pfam12547
Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 ...
 1-112 3.23e-07

Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 protein.


Pssm-ID: 463627  Cd Length: 531  Bit Score: 52.51  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963611    1 MKPVHERNQECLPPKKRDLPmtscstnhtSSSDASEwSRGVVVA--GQSQAG------ARVSLGGDGAEAITGLTVDQYG 72
Cdd:pfam12547   1 MKSNQERSNECLPPKKREIP---------ASTLPSE-EKPVVMApaSESQRGenlawlASVAGGQESGGGRTETSSQSDG 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   73 MLYKVAVPPATFSP-------------TGLPSVLQEPDVWSPSRGQPVSLHLP 112
Cdd:pfam12547  71 PQYKPLSTASDYSSpsssrsssslrvvTSLPAVYTSPLSQSGAGGTVQYTQLP 123
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 147-211 2.86e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 2.86e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767963611  147 DAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 211
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 218-283 1.08e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 99.08  E-value: 1.08e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  218 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 283
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 378-443 1.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.00  E-value: 1.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767963611  378 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 443
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
159-211 9.58e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 85.15  E-value: 9.58e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   159 GTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 211
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 302-368 1.80e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.83  E-value: 1.80e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963611  302 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTV 368
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
231-283 1.12e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 79.37  E-value: 1.12e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   231 GTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 283
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
391-443 1.50e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 1.50e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   391 GTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 443
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
316-368 2.06e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 2.06e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   316 GTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTV 368
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ATXN-1_C pfam12547
Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 ...
 1-112 3.23e-07

Ataxin-1 like family; This entry represents the N-terminal and central region of the Ataxin-1 protein.


Pssm-ID: 463627  Cd Length: 531  Bit Score: 52.51  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963611    1 MKPVHERNQECLPPKKRDLPmtscstnhtSSSDASEwSRGVVVA--GQSQAG------ARVSLGGDGAEAITGLTVDQYG 72
Cdd:pfam12547   1 MKSNQERSNECLPPKKREIP---------ASTLPSE-EKPVVMApaSESQRGenlawlASVAGGQESGGGRTETSSQSDG 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767963611   73 MLYKVAVPPATFSP-------------TGLPSVLQEPDVWSPSRGQPVSLHLP 112
Cdd:pfam12547  71 PQYKPLSTASDYSSpsssrsssslrvvTSLPAVYTSPLSQSGAGGTVQYTQLP 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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