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Conserved domains on  [gi|767973423|ref|XP_011536310|]
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epiphycan isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-240 3.12e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 168
Cdd:COG4886  123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973423 169 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 240
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRRNT smart00013
Leucine rich repeat N-terminal domain;
60-84 1.05e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 1.05e-03
                           10        20
                   ....*....|....*....|....*.
gi 767973423    60 CTCISTTVYCDDHELDAIPP-LPKNT 84
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-240 3.12e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 168
Cdd:COG4886  123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973423 169 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 240
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
90-142 4.43e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 4.43e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767973423   90 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 142
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-256 9.96e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 9.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  65 TTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINkndfASLSD-LKRIDLTSNLISEIDE-------------DAFRKL 129
Cdd:PRK15370 202 TTLILDNNELKSLPEnLQGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPErlpsalqsldlfhNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 130 PQ-----LRELVLRDNKIRQLPE-LPTTLTFIDISNNRLgrkgikqEAFKDMY--DLHHLYLTDNNLDHIPLPLPENLRA 201
Cdd:PRK15370 278 PEnlpeeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSL-------TALPETLppGLKTLEAGENALTSLPASLPPELQV 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767973423 202 LHLQNNNILEMHEDTFCNVKNLTYIRKALedIRLDGN-PINLSKTPQAYMCLPRLP 256
Cdd:PRK15370 351 LDVSKNQITVLPETLPPTITTLDVSRNAL--TNLPENlPAALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-240 1.97e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKINknDFASLSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKI----------RQLPELPTTLTFIDISNNR 161
Cdd:cd21340   56 NQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekltfdpRSLAALSNSLRVLNISGNN 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973423 162 LGrkgikqeafkDMYDLHHLYltdnnldhiplplpeNLRALHLQNNNILEMhEDTFCNVKNLTYirkaLEDIRLDGNPI 240
Cdd:cd21340  132 ID----------SLEPLAPLR---------------NLEQLDASNNQISDL-EELLDLLSSWPS----LRELDLTGNPV 180
LRRNT smart00013
Leucine rich repeat N-terminal domain;
60-84 1.05e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 1.05e-03
                           10        20
                   ....*....|....*....|....*.
gi 767973423    60 CTCISTTVYCDDHELDAIPP-LPKNT 84
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 60-81 1.56e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|...
gi 767973423   60 CTCISTTVYCDDHELDAIPP-LP 81
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-240 3.12e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKINKnDFASLSDLKRIDLTSNLISEIDEdAFRKLPQLRELVLRDNKIRQLPELP---TTLTFIDISNNRLGRKGik 168
Cdd:COG4886  123 NQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQITDLP-- 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973423 169 qEAFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNIlemheDTFCNVKNLTyirkALEDIRLDGNPI 240
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQL-----TDLPELGNLT----NLEELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
90-142 4.43e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 4.43e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767973423   90 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 142
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-256 9.96e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 9.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  65 TTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINkndfASLSD-LKRIDLTSNLISEIDE-------------DAFRKL 129
Cdd:PRK15370 202 TTLILDNNELKSLPEnLQGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPErlpsalqsldlfhNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 130 PQ-----LRELVLRDNKIRQLPE-LPTTLTFIDISNNRLgrkgikqEAFKDMY--DLHHLYLTDNNLDHIPLPLPENLRA 201
Cdd:PRK15370 278 PEnlpeeLRYLSVYDNSIRTLPAhLPSGITHLNVQSNSL-------TALPETLppGLKTLEAGENALTSLPASLPPELQV 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767973423 202 LHLQNNNILEMHEDTFCNVKNLTYIRKALedIRLDGN-PINLSKTPQAYMCLPRLP 256
Cdd:PRK15370 351 LDVSKNQITVLPETLPPTITTLDVSRNAL--TNLPENlPAALQIMQASRNNLVRLP 404
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-261 3.68e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKInKNDFASLSDLKRIDLTSNLISEIDEDaFRKLPQLRELVLRDNKIRQLPELP--TTLTFIDISNNRLgrKGIKQ 169
Cdd:COG4886  192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQL--TDLPP 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 170 EAfkDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFcNVKNLTYIRKALEDIRLDGNPINLSKTPQAY 249
Cdd:COG4886  268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL-LILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                        170
                 ....*....|..
gi 767973423 250 MCLPRLPVGSLV 261
Cdd:COG4886  345 SLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-240 1.38e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  94 IKKINKNDFASLSDLKRIDLTSNliseideDAFRKLPQLRELVLRDNKIRQLPEL---PTTLTFIDISNNRLGRKGikqE 170
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP---E 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 171 AFKDMYDLHHLYLTDNNLDHIPLPLPE--NLRALHLQNNNILEMHEdTFCNVKNLTYIR----------------KALED 232
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDlsgnqltdlpeplanlTNLET 232


                 ....*...
gi 767973423 233 IRLDGNPI 240
Cdd:COG4886  233 LDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
108-162 2.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 2.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  108 LKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPE-----LPtTLTFIDISNNRL 162
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsgLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
150-209 1.40e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973423  150 TTLTFIDISNNRLgrKGIKQEAFKDMYDLHHLYLTDNNLDHIPL----PLPeNLRALHLQNNNI 209
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-240 1.97e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  92 NRIKKINknDFASLSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKI----------RQLPELPTTLTFIDISNNR 161
Cdd:cd21340   56 NQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekltfdpRSLAALSNSLRVLNISGNN 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973423 162 LGrkgikqeafkDMYDLHHLYltdnnldhiplplpeNLRALHLQNNNILEMhEDTFCNVKNLTYirkaLEDIRLDGNPI 240
Cdd:cd21340  132 ID----------SLEPLAPLR---------------NLEQLDASNNQISDL-EELLDLLSSWPS----LRELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 106-209 4.19e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 106 SDLKRIDLTSNLISEID----EDAFRKLPQLRELVLRDNKIRQ------LPELP--TTLTFIDISNNRLGRKGIKQ--EA 171
Cdd:cd00116  137 PALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDagiralAEGLKanCNLEVLDLNNNGLTDEGASAlaET 216

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767973423 172 FKDMYDLHHLYLTDNNLDHIP--------LPLPENLRALHLQNNNI 209
Cdd:cd00116  217 LASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-188 3.06e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 101 DFASLSDLKRIDLTSNLISEID----EDAFRKLPQLRELVLRDNKIR---------QLPELPTTLTFIDISNNRLGRKGI 167
Cdd:cd00116  188 GLKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTdagaaalasALLSPNISLLTLSLSCNDITDDGA 267

                         90       100
                 ....*....|....*....|...
gi 767973423 168 KQ--EAFKDMYDLHHLYLTDNNL 188
Cdd:cd00116  268 KDlaEVLAEKESLLELDLRGNKF 290
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 111-209 4.69e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 111 IDLTSNLISE--IDE--DAFRKLPQLRELVLRDNKI--RQLPEL------PTTLTFIDISNNRLGRKGIKQ--EAFKDMY 176
Cdd:COG5238  185 VYLGCNQIGDegIEElaEALTQNTTVTTLWLKRNPIgdEGAEILaealkgNKSLTTLDLSNNQIGDEGVIAlaEALKNNT 264

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767973423 177 DLHHLYLTDNNLDH-------IPLPLPENLRALHLQNNNI 209
Cdd:COG5238  265 TVETLYLSGNQIGAegaialaKALQGNTTLTSLDLSVNRI 304
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
130-214 2.27e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 130 PQLRELVLRDNKIRQLPE-LPTTLTFIDISNNRLGrkgIKQEAFKDMydLHHLYLTDNNLDHIPLPLPENLRALHLQNNN 208
Cdd:PRK15370 325 PGLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPPT--ITTLDVSRNALTNLPENLPAALQIMQASRNN 399


                 ....*.
gi 767973423 209 ILEMHE 214
Cdd:PRK15370 400 LVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-211 8.64e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 8.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 105 LSDLKRIDLTSNLISEIDedAFRKLPQLRELVLRDNKIrqLPELP---------TTLTFIDISNNRLGRKG--IKQEAFK 173
Cdd:cd00116   58 LSLNETGRIPRGLQSLLQ--GLTKGCGLQELDLSDNAL--GPDGCgvlesllrsSSLQELKLNNNGLGDRGlrLLAKGLK 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767973423 174 DMY-DLHHLYLTDNNLDHIP-------LPLPENLRALHLQNNNILE 211
Cdd:cd00116  134 DLPpALEKLVLGRNRLEGAScealakaLRANRDLKELNLANNGIGD 179
LRRNT smart00013
Leucine rich repeat N-terminal domain;
60-84 1.05e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.76  E-value: 1.05e-03
                           10        20
                   ....*....|....*....|....*.
gi 767973423    60 CTCISTTVYCDDHELDAIPP-LPKNT 84
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDT 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 101-207 1.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423 101 DFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIR-QLP-ELPT--TLTFIDISNNRLgrKGIKQEAFKDMY 176
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPdELSSckKLVSLDLSHNQL--SGQIPASFSEMP 547

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767973423 177 DLHHLYLTDNNLD-HIPLPLP--ENLRALHLQNN 207
Cdd:PLN00113 548 VLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 178-240 1.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 1.19e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973423 178 LHHLYLTDNNLDHIP-LPLPENLRALHLQNNNILEMhedtfCNVKNLtyirKALEDIRLDGNPI 240
Cdd:cd21340   26 LKVLYLYDNKITKIEnLEFLTNLTHLYLQNNQIEKI-----ENLENL----VNLKKLYLGGNRI 80
LRR_8 pfam13855
Leucine rich repeat;
178-240 1.29e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973423  178 LHHLYLTDNNLDHIP------LPlpeNLRALHLQNNNILEMHEDTFCNVKNLTYirkaledIRLDGNPI 240
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgafkgLS---NLKVLDLSNNLLTTLSPGAFSGLPSLRY-------LDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 60-81 1.56e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|...
gi 767973423   60 CTCISTTVYCDDHELDAIPP-LP 81
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
71-164 4.53e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.22  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  71 DHELDAIPPLPKNTAYFYSRFNRIKKINkndfASLSDLKRIDLTSNLISEIDedafrKLP-QLRELVLRDNKIRQLPELP 149
Cdd:PRK15387 351 DNQLASLPTLPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLP-----VLPsELKELMVSGNRLTSLPMLP 421

                         90
                 ....*....|....*
gi 767973423 150 TTLTFIDISNNRLGR 164
Cdd:PRK15387 422 SGLLSLSVYRNQLTR 436
LRR_9 pfam14580
Leucine-rich repeat;
133-226 7.11e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 36.28  E-value: 7.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973423  133 RELVLRDNKIRQLPELPTTL---TFIDISNNRLgrkgIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPE---NLRALHLQN 206
Cdd:pfam14580  22 RELDLRGYKIPIIENLGATLdqfDTIDFSDNEI----RKLDGFPLLRRLKTLLLNNNRICRIGEGLGEalpNLTELILTN 97

                          90       100
                  ....*....|....*....|.
gi 767973423  207 NNILEMHE-DTFCNVKNLTYI 226
Cdd:pfam14580  98 NNLQELGDlDPLASLKKLTFL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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