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Conserved domains on  [gi|767972912|ref|XP_011536093|]
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citron Rho-interacting kinase isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972912   1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767972912   830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767972912  1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767972912 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449  605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972912   1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1192-1444 8.76e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 229.44  E-value: 8.76e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1192 SDQVVLVGTEEGLYALNV-LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDISP 1270
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1271 NIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1348
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1349 QYTLEEFLdkndhsLAPAVFAASSNSFPVSIVQVNsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1428
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 767972912  1429 YLFVTHFNSLEVIEIQ 1444
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767972912   830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 166-777 1.05e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 1.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  166 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEerrhslenkvKRLETME 245
Cdd:COG1196   209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  246 RRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 325
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  326 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 405
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  406 NRKLEEQLEKISHQDHSDKNRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 482
Cdd:COG1196   430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  483 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasGANDEIVQ 562
Cdd:COG1196   510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE----------------VAAAAIEY 565

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQR 642
Cdd:COG1196   566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  643 MLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:COG1196   646 LREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA 725

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  723 ElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 777
Cdd:COG1196   726 L-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-874 6.16e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.96  E-value: 6.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    15 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 94
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    95 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 170
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   171 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENR 250
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   251 LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAH 330
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   331 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkLEAQNRKLE 410
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS--------------GLKVLLALI 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   411 EQLEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:pfam02463  517 KDGVGGRIISAHGRLGDLGvaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:pfam02463  597 LEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL 676

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   569 HLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam02463  677 EIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   648 KQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQR 727
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEEL 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   728 LLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:pfam02463  836 EELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLN 910

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   808 QPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 874
Cdd:pfam02463  911 LLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
PTZ00121 PTZ00121
MAEBL; Provisional
 5-771 1.38e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.90  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 82
Cdd:PTZ00121 1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   83 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKATECQ--HKLLKAKDQGKPEVG 156
Cdd:PTZ00121 1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAEAA 1205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  157 EYAKLEKiNAEQQLKIQElqEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PTZ00121 1206 RKAEEER-KAEEARKAED--AKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  236 nkVKRLETMERRENRLKDDIQTKSQQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 312
Cdd:PTZ00121 1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 392
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  393 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSD--------KNRLLELETRLREVSLEHEE--QKLELKRQLTELQLSL 459
Cdd:PTZ00121 1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADeakkkaeeAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAE 1519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  460 QERES-QLTALQAARAALE----SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTE 534
Cdd:PTZ00121 1520 EAKKAdEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEE 1591

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVMDLEALNDE 611
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKK 1669

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  612 LLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAE 691
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAE 1747

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  692 SLsdKLNDLEKK---HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS 768
Cdd:PTZ00121 1748 EA--KKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825


                  ...
gi 767972912  769 DLE 771
Cdd:PTZ00121 1826 EME 1828
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1192-1443 8.45e-11

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 67.22  E-value: 8.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1192 SDQVVLVGTEEGLYALNVLKNS--------LTHVPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1263
Cdd:COG5422   868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1264 aqpDISPNIFEAVK-----GCHLFGAGKiENGLCICAAMPSKVVILRYN------ENLSKYCIRKEIETSEPCScIHFTN 1332
Cdd:COG5422   944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNksgnlkKALTIELSTELYVPSEPLS-VHFLK 1018

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1333 YSILIGTNKFYEI-DMKQYTLEEFLDKNDHSlaPAVFAASSNSFPVSIVQVNSagqreEYLLCFHEFGVFVDSYGRRSRT 1411
Cdd:COG5422  1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                         250       260       270
                  ....*....|....*....|....*....|...
gi 767972912 1412 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1443
Cdd:COG5422  1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 939-987 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 767972912    939 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 987
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767972912  1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1020-1139 2.67e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.67e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1099
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 767972912   1100 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 934-989 1.91e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   934 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767972912 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449  605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1021-1066 6.53e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767972912 1021 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1066
Cdd:cd01242     2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1184-1480 4.78e-74

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 249.19  E-value: 4.78e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1184 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1256
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1257 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1330
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1331 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1406
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972912   1407 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1480
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1192-1444 8.76e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 229.44  E-value: 8.76e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1192 SDQVVLVGTEEGLYALNV-LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDISP 1270
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1271 NIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1348
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1349 QYTLEEFLdkndhsLAPAVFAASSNSFPVSIVQVNsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1428
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 767972912  1429 YLFVTHFNSLEVIEIQ 1444
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 935-990 3.84e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.61  E-value: 3.84e-38
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20814     1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 65-877 7.38e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 116.31  E-value: 7.38e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    65 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 130
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   131 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 210
Cdd:TIGR02168  277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   211 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 289
Cdd:TIGR02168  343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   290 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 369
Cdd:TIGR02168  416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   370 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 442
Cdd:TIGR02168  477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   443 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 520
Cdd:TIGR02168  547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   521 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   593 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 672
Cdd:TIGR02168  705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   673 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 752
Cdd:TIGR02168  769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   753 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767972912   830 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 877
Cdd:TIGR02168  927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-770 1.30e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.30e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     2 MEQEMTRLHRRVSEVEAVL----SQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqedDKALQLLHDIR 77
Cdd:TIGR02168  184 TRENLDRLEDILNELERQLksleRQAEKAERYKELKAELRELELALLVLRLEELREELEELQEEL----KEAEEELEELT 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    78 EQSrklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRR--------SDLyESELRE--SRLAAEEFKRKATECQHKLLKA 147
Cdd:TIGR02168  260 AEL--------QELEEKLEELRLEVSELEEEIEELQKElyalaneiSRL-EQQKQIlrERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   148 KDQGKPEvgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRKKLVEA 227
Cdd:TIGR02168  331 KLDELAE--ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS---LNNEIERL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   228 EERRHSLENKVKRL-----ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIK 302
Cdd:TIGR02168  406 EARLERLEDRRERLqqeieELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   303 VLDNQIkkdladkETLENMMQRHEEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMK 379
Cdd:TIGR02168  486 QLQARL-------DSLERLQENLEGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLN 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   380 AQEEMISELRQQK-----FYLETQAGKLEAQNRKLEE------------QLEKISHQDHSDKNRLL-------------- 428
Cdd:TIGR02168  557 AAKKAIAFLKQNElgrvtFLPLDSIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlvvddldnale 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   429 ---ELETRLREVSLE-------------HEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 489
Cdd:TIGR02168  637 lakKLRPGYRIVTLDgdlvrpggvitggSAKTNssiLERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQ 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   490 TTAEAEEEIQALTAHRDEIQRkfdalrnsctvitdLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDH 569
Cdd:TIGR02168  717 LRKELEELSRQISALRKDLAR--------------LEAEVEQLEERIAQLSKE---LTELEAEIEELEERLEEAEEELAE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   570 LRREITEREMQLtsqKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRM-LDTEK 648
Cdd:TIGR02168  780 AEAEIEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELsEDIES 856

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   649 QSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----EL 724
Cdd:TIGR02168  857 LAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElrleGL 934

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|
gi 767972912   725 KQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDL 770
Cdd:TIGR02168  935 EVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 5-778 4.31e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 107.45  E-value: 4.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqeddkaLQLLHDIREQSRKLQ 84
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL-------YALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    85 EIKEQEYQAQVEEMRLmmnqlEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLlkakdqgkpevgeyAKLEKI 164
Cdd:TIGR02168  306 ILRERLANLERQLEEL-----EAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL--------------EELEAE 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   165 NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ----NREDSSEGIRKKLVEAE---------ERR 231
Cdd:TIGR02168  367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdrreRLQQEIEELLKKLEEAElkelqaeleELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   232 HSLENKVKRLETMERRENRLKDDIQTKSQQIQQmadkileLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 311
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDA-------AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLS 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   312 -----LADKETLENMMQRHEEEAHEK--GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR02168  520 gilgvLSELISVDEGYEAAIEAALGGrlQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEG 599

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   385 ISELRQQKFYLETQAGKL---------------EAQN--RKLEEQLEKISHQDHSDKNR-LLELETRLREVSLEHEEQKL 446
Cdd:TIGR02168  600 FLGVAKDLVKFDPKLRKAlsyllggvlvvddldNALElaKKLRPGYRIVTLDGDLVRPGgVITGGSAKTNSSILERRREI 679

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   447 -ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDL 525
Cdd:TIGR02168  680 eELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   526 EEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 605
Cdd:TIGR02168  760 EAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   606 EALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQA 682
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRselEELSEELRELESKRSELRRE 916

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   683 LKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ----KNHIFRLTQGLQE--- 755
Cdd:TIGR02168  917 LEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDDeeeaRRRLKRLENKIKElgp 986

                          810       820       830
                   ....*....|....*....|....*....|....
gi 767972912   756 ----ALD-------RADLLKTERSDLEYQLENIQ 778
Cdd:TIGR02168  987 vnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 166-777 1.05e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 106.17  E-value: 1.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  166 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEerrhslenkvKRLETME 245
Cdd:COG1196   209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  246 RRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 325
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  326 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 405
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  406 NRKLEEQLEKISHQDHSDKNRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 482
Cdd:COG1196   430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  483 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasGANDEIVQ 562
Cdd:COG1196   510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE----------------VAAAAIEY 565

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQR 642
Cdd:COG1196   566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  643 MLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:COG1196   646 LREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA 725

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  723 ElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 777
Cdd:COG1196   726 L-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 229-789 8.37e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 103.09  E-value: 8.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  229 ERRHSLENKvkrLETMERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 300
Cdd:COG1196   172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  301 IKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 380
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVS----------LEHEEQKLELKR 450
Cdd:COG1196   321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  451 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 530
Cdd:COG1196   401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  531 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQ---------K 585
Cdd:COG1196   481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNivveddevaA 560

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  586 QTMEALKTT----CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 661
Cdd:COG1196   561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  662 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 741
Cdd:COG1196   641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 767972912  742 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 789
Cdd:COG1196   721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 124-771 2.57e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.55  E-value: 2.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  124 RESRLAAE--EFKRKATECQHKLLKAKDQGKpevgeYAKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKE 201
Cdd:COG1196   207 RQAEKAERyrELKEELKELEAELLLLKLREL-----EAELEELEAE----LEELEAELEELEAELAELEAELEELRLELE 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  202 RAERELEKLQNREdssEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQV 281
Cdd:COG1196   278 ELELELEEAQAEE---YELLAELARLEQDIARLEERRREL---EERLEELEEELAELEEELEELEEELEELEEELEEAEE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  282 SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAhekgkilseqkaminamdSKIRSLEQRIvels 361
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA------------------AQLEELEEAE---- 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  362 eanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEH 441
Cdd:COG1196   410 -------------EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE--------AELEEEEEALLELLAEL 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  442 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctv 521
Cdd:COG1196   469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA--- 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  522 itDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM-- 597
Cdd:COG1196   544 --LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGdt 621

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  598 LEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 677
Cdd:COG1196   622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALL 700

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  678 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-- 755
Cdd:COG1196   701 AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlg 780

                         650       660
                  ....*....|....*....|....*...
gi 767972912  756 -----ALD-------RADLLKTERSDLE 771
Cdd:COG1196   781 pvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1-720 3.88e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.90  E-value: 3.88e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:TIGR02168  250 EAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELE 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    81 RKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:TIGR02168  330 SKLDELAEelaeleeklEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   152 KPEVGEYAKLEKINAEQQ-----LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSegiRKKLVE 226
Cdd:TIGR02168  410 ERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAA---ERELAQ 486

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   227 AEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKIlELEEKHREA-----QVSAQHLEV-----------HL 290
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELI-SVDEGYEAAieaalGGRLQAVVVenlnaakkaiaFL 565

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   291 KQKE----------QHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL-----EQ 355
Cdd:TIGR02168  566 KQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAkklrpGY 645

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   356 RIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 417
Cdd:TIGR02168  646 RIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELS 725

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   418 HQDHSDKNRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA 494
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   495 EEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgandeivqLRSEV 567
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEE----------LESEL 875

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   568 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRML--- 644
Cdd:TIGR02168  876 EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTlee 955

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   645 -----DTEKQSRARADQRITESRQ------VVELAVKEHKAEILALQQALKEQKlkaESLSDKLNDLEKkhAMLEMNARS 713
Cdd:TIGR02168  956 aealeNKIEDDEEEARRRLKRLENkikelgPVNLAAIEEYEELKERYDFLTAQK---EDLTEAKETLEE--AIEEIDREA 1030


                   ....*..
gi 767972912   714 LQQKLET 720
Cdd:TIGR02168 1031 RERFKDT 1037
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 167-870 7.26e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.13  E-value: 7.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   167 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLQNREDSSEG--IRKKLVEAEERRHSLENKVKRletM 244
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   245 ERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 321
Cdd:TIGR02168  252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   322 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 401
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   402 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 481
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   482 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 561
Cdd:TIGR02168  472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   562 QLRSEV---------DHLRREITERemqLTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSV 625
Cdd:TIGR02168  530 SVDEGYeaaieaalgGRLQAVVVEN---LNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKD 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   626 LGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQK 687
Cdd:TIGR02168  607 LVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEELE 683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   688 LKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 767
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   768 SDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 847
Cdd:TIGR02168  757 TELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832

                          730       740
                   ....*....|....*....|...
gi 767972912   848 CAELEEALQKTRIELRSAREEAA 870
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 197-775 2.80e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.09  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  197 RQAkERAER--ELEKlqnredssegiRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE 274
Cdd:COG1196   207 RQA-EKAERyrELKE-----------ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  275 KHREAQVSAQhlevHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE 354
Cdd:COG1196   275 ELEELELELE----EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  355 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishQDHSDKNRLLELETRL 434
Cdd:COG1196   351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE----ALLERLERLEEELEEL 426

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  435 REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAhrDEIQRKFDA 514
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL--LLEAEADYE 504

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  515 LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD------HLRREITEREMQLTSQKqtM 588
Cdd:COG1196   505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVaaaaieYLKAAKAGRATFLPLDK--I 582

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  589 EALKTTCTMLEEQVMDLEALndeLLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG1196   583 RARAALAAALARGAIGAAVD---LVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  669 VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFR 748
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739

                         570       580
                  ....*....|....*....|....*..
gi 767972912  749 LTQGLQEALDRADLLKTERSDLEYQLE 775
Cdd:COG1196   740 ELLEEEELLEEEALEELPEPPDLEELE 766
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 15-874 6.16e-20

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.96  E-value: 6.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    15 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 94
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    95 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 170
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   171 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENR 250
Cdd:pfam02463  291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   251 LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAH 330
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   331 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkLEAQNRKLE 410
Cdd:pfam02463  451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS--------------GLKVLLALI 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   411 EQLEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:pfam02463  517 KDGVGGRIISAHGRLGDLGvaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:pfam02463  597 LEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL 676

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   569 HLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam02463  677 EIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   648 KQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQR 727
Cdd:pfam02463  757 LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEEL 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   728 LLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:pfam02463  836 EELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLN 910

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   808 QPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 874
Cdd:pfam02463  911 LLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 193-778 1.10e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 95.86  E-value: 1.10e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   193 LQNIRQAKERAERELEK--------LQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQ 264
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   265 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KETLENMMQRHEE 327
Cdd:TIGR04523  101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   328 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 402
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   403 EAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 467
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   468 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 545
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   546 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV----MDLEALNDELLEKERQW 619
Cdd:TIGR04523  419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKEL 498

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   620 EAwrsvLGDEKSQFECRVRELqrmldTEKQSraradqritesrqvvELAVKEHKAEILALQqalKEQKLKaeSLSDKLN- 698
Cdd:TIGR04523  499 KK----LNEEKKELEEKVKDL-----TKKIS---------------SLKEKIEKLESEKKE---KESKIS--DLEDELNk 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   699 -DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL-------DRADLLKTERSDL 770
Cdd:TIGR04523  550 dDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkissleKELEKAKKENEKL 629


                   ....*...
gi 767972912   771 EYQLENIQ 778
Cdd:TIGR04523  630 SSIIKNIK 637
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 50-702 2.62e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 95.00  E-value: 2.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   50 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 129
Cdd:COG1196   204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  130 AEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK 209
Cdd:COG1196   276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  210 LQNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEV 288
Cdd:COG1196   356 AEAELAEAEEALLEAEAElAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  289 HLKQKEQHYEEKIKvldnQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAA 368
Cdd:COG1196   436 EEEEEEEALEEAAE----EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  369 NSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRkleeqlekishqdhsdKNRLLELETRLREVSlehEEQKLEL 448
Cdd:COG1196   512 AALLLAGLRGLAGA--VAVLIGVEAAYEAALEAALAAAL----------------QNIVVEDDEVAAAAI---EYLKAAK 570

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  449 KRQLTELQLSLQERESQLTALQAARAALESQLRQAkTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ 528
Cdd:COG1196   571 AGRATFLPLDKIRARAALAAALARGAIGAAVDLVA-SDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREV 649

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  529 LNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEAL 608
Cdd:COG1196   650 TLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQ 729

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  609 NDELLEKERQWEawrsvLGDEKSQFECRVRELQRMLDTEKQSR--ARADQRITESRQVVELAVKEHkaeilalqQALKEQ 686
Cdd:COG1196   730 LEAEREELLEEL-----LEEEELLEEEALEELPEPPDLEELERelERLEREIEALGPVNLLAIEEY--------EELEER 796

                         650
                  ....*....|....*.
gi 767972912  687 KlkaESLSDKLNDLEK 702
Cdd:COG1196   797 Y---DFLSEQREDLEE 809
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-573 5.92e-19

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 93.85  E-value: 5.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:COG1196   252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   83 LQEIKEQ---------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQgkp 153
Cdd:COG1196   332 LEELEEEleeleeeleEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA--- 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  154 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:COG1196   409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQ---MADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKK 310
Cdd:COG1196   489 AAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKA 568

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  311 DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISE 387
Cdd:COG1196   569 AKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRE 648

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  388 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLT 467
Cdd:COG1196   649 VTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEE 724

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  468 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELN 540
Cdd:COG1196   725 ALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE----------LERLEREIEALgpvnllaIEEYEELE 794

                         570       580       590
                  ....*....|....*....|....*....|...
gi 767972912  541 NQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 573
Cdd:COG1196   795 ERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
PTZ00121 PTZ00121
MAEBL; Provisional
 5-771 1.38e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.90  E-value: 1.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    5 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 82
Cdd:PTZ00121 1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   83 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKATECQ--HKLLKAKDQGKPEVG 156
Cdd:PTZ00121 1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAEAA 1205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  157 EYAKLEKiNAEQQLKIQElqEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PTZ00121 1206 RKAEEER-KAEEARKAED--AKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  236 nkVKRLETMERRENRLKDDIQTKSQQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 312
Cdd:PTZ00121 1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 392
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  393 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSD--------KNRLLELETRLREVSLEHEE--QKLELKRQLTELQLSL 459
Cdd:PTZ00121 1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADeakkkaeeAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAE 1519

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  460 QERES-QLTALQAARAALE----SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTE 534
Cdd:PTZ00121 1520 EAKKAdEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEE 1591

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVMDLEALNDE 611
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKK 1669

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  612 LLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAE 691
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAE 1747

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  692 SLsdKLNDLEKK---HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS 768
Cdd:PTZ00121 1748 EA--KKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825


                  ...
gi 767972912  769 DLE 771
Cdd:PTZ00121 1826 EME 1828
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 9-778 1.52e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 92.44  E-value: 1.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     9 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 88
Cdd:TIGR02169  216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    89 QEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELREsrlaAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAE 167
Cdd:TIGR02169  287 EEQLRVKEKIG----ELEAEIASLERSIAEKERELED----AEERLAKLEAEIDKLLAEIEELEREIEEERKrRDKLTEE 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   168 qqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS----LENKVKRLET 243
Cdd:TIGR02169  359 ----YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEeladLNAAIAGIEA 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   244 ----MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK-----------------IK 302
Cdd:TIGR02169  435 kineLEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAeaqaraseervrggravEE 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   303 VLDNQIKK-------------------DLADKETLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE--- 354
Cdd:TIGR02169  515 VLKASIQGvhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSils 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   355 -----QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKNRL 427
Cdd:TIGR02169  595 edgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRG 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   428 LELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:TIGR02169  665 GILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE 744

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   507 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLskqldEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ 586
Cdd:TIGR02169  745 DLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL-----EARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQ 819

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ---RMLDTEKQSRARADQRITESRQ 663
Cdd:TIGR02169  820 KLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLKKERDELEAQLR 899

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDLQk 743
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE----EIPEEELSLEDVQAELQRVEEEIRALEPVN- 974

                          810       820       830
                   ....*....|....*....|....*....|....*
gi 767972912   744 nhiFRLTQGLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:TIGR02169  975 ---MLAIQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 3-436 6.69e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.50  E-value: 6.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    83 LQEIKEQEyqaqveemrlmmnqleedlvsarrrsDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 162
Cdd:TIGR02168  756 LTELEAEI--------------------------EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   163 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ-NREDSSEGIRKKLVEAEErrhslenKVKRL 241
Cdd:TIGR02168  810 AELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAaEIEELEELIEELESELEA-------LLNER 882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   242 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLkqkeqhyeEKIKVLDNQIKKDLADKETLENM 321
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL--------EGLEVRIDNLQERLSEEYSLTLE 954

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   322 MQrheeEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEANKLAansslftqrnmkaqEEMISELRQQKFYLETQAGK 401
Cdd:TIGR02168  955 EA----EALENKIEDDEEEA-----RRRLKRLENKIKELGPVNLAA--------------IEEYEELKERYDFLTAQKED 1011

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 767972912   402 LEAQNRKLEEQLEKIshqDHSDKNRLLELETRLRE 436
Cdd:TIGR02168 1012 LTEAKETLEEAIEEI---DREARERFKDTFDQVNE 1043
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 3-814 8.24e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 90.03  E-value: 8.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI--REQS 80
Cdd:pfam02463  264 EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIeeLEKE 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    81 RKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAkdqgkpevgeyAK 160
Cdd:pfam02463  344 LKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKE-----------AQ 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   161 LEKINAEQQLKI-QELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegirKKLVEAEERRHSLENKVK 239
Cdd:pfam02463  409 LLLELARQLEDLlKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL---------KDELELKKSEDLLKETQL 479

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   240 RLETMERRENRLKDDIQTKSQQiqqmadkilelEEKHREAqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQK-----------ESKARSG------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYK 542

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   320 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQA 399
Cdd:pfam02463  543 VAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRA 622

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   400 GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaarAALESQ 479
Cdd:pfam02463  623 KVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESEL-------AKEEIL 695

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   480 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgande 559
Cdd:pfam02463  696 RRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE------- 768

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   560 iVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfECRVRE 639
Cdd:pfam02463  769 -LSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELAL-ELKEEQ 846

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   640 LQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 719
Cdd:pfam02463  847 KLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEE 926

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   720 TERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKlI 799
Cdd:pfam02463  927 AEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEK-K 1005

                          810
                   ....*....|....*
gi 767972912   800 DFLQAKMDQPAKKKK 814
Cdd:pfam02463 1006 KLIRAIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 214-871 4.17e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 4.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   214 EDSSEGIRKKLVEA------EERRHSLENKvkrLETMERRENRLKDDI-----QTKSQQIQ-QMADKILELEEKHREAQ- 280
Cdd:TIGR02168  151 EAKPEERRAIFEEAagiskyKERRKETERK---LERTRENLDRLEDILnelerQLKSLERQaEKAERYKELKAELRELEl 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   281 -VSAQHLEVHLKQKEQ------HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL 353
Cdd:TIGR02168  228 aLLVLRLEELREELEElqeelkEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   354 EQRIVELseanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 433
Cdd:TIGR02168  308 RERLANL--------------ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   434 LREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALT 502
Cdd:TIGR02168  374 LEELEEQLETLRskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEEllkkleeaELKELQAELEELEEELEELQ 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   503 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE-------VDHLRREIT 575
Cdd:TIGR02168  454 EELERLEEALEELREE---LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNqsglsgiLGVLSELIS 530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   576 ERE-------------MQ------LTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSVLGDE 629
Cdd:TIGR02168  531 VDEgyeaaieaalggrLQavvvenLNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKDLVKF 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   630 KSQFE---------CRV-------RELQRMLD------TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQK 687
Cdd:TIGR02168  611 DPKLRkalsyllggVLVvddldnaLELAKKLRpgyrivTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELE 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   688 LKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:TIGR02168  691 EKIAELEKALAELRKELEELEEELEQLRKELEElsrqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   761 DLLKTERSDLEYQLENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLA 840
Cdd:TIGR02168  771 EEAEEELAEAEAEIEELEAQIE----QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750
                   ....*....|....*....|....*....|.
gi 767972912   841 LEKEKARCAELEEALQKTRIELRSAREEAAH 871
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELESELEA 877
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
12-578 1.03e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 86.27  E-value: 1.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   12 RVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqaRMEVSQEDDKALQLLHDIREQSRKLQEIKEQEY 91
Cdd:PRK03918  187 RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK--ELEELKEEIEELEKELESLEGSKRKLEEKIREL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   92 QAQVEEMRLMMNQLEEdlvSARRRSDLYESELRESRLaaEEFKRKATECQHKLLKakdqgkpevgEYAKLEKINAEQQLK 171
Cdd:PRK03918  265 EERIEELKKEIEELEE---KVKELKELKEKAEEYIKL--SEFYEEYLDELREIEK----------RLSRLEEEINGIEER 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  172 IQELQEKLEKAVKASTEATELLQNIRQAKERAErELEKLQNREDSSEGIRKKL--VEAEERRHSLENKVKRLETMERREN 249
Cdd:PRK03918  330 IKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLtgLTPEKLEKELEELEKAKEEIEEEIS 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  250 RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkqkEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 329
Cdd:PRK03918  409 KITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  330 HEKGKILSEQKAMI--NAMDSKIRSLEQRIVELsEANKLAANSSLFTqrnmKAQEEMIsELRQQKFYLETQAGKLEAQNR 407
Cdd:PRK03918  483 RELEKVLKKESELIklKELAEQLKELEEKLKKY-NLEELEKKAEEYE----KLKEKLI-KLKGEIKSLKKELEKLEELKK 556

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  408 KLEEQLEKIshqdHSDKNRLLELETRLREVSLEHEEqklELKRQLTELQ------LSLQERESQLTALQAARAALESQLR 481
Cdd:PRK03918  557 KLAELEKKL----DELEEELAELLKELEELGFESVE---ELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELD 629

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  482 QAktelEETTAEAEEEIQALTAHRDEIQRKFDalrnsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIv 561
Cdd:PRK03918  630 KA----FEELAETEKRLEELRKELEELEKKYS------------EEEYEELREEYLELSRELAGLRAELEELEKRREEI- 692

                         570
                  ....*....|....*..
gi 767972912  562 qlRSEVDHLRREITERE 578
Cdd:PRK03918  693 --KKTLEKLKEELEERE 707
PTZ00121 PTZ00121
MAEBL; Provisional
 3-445 3.30e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.19  E-value: 3.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQAR-----MEVSQEDDKALQLLHDIR 77
Cdd:PTZ00121 1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKkadeaKKKAEEAKKKADAAKKKA 1338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   78 EQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV---SARRRSDLYESELRESRLA------AEEFKRKATECQHKLLKAK 148
Cdd:PTZ00121 1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKkkeEAKKKADAAKKKAEEKKKAdeakkkAEEDKKKADELKKAAAAKK 1418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  149 --DQGKPEVGEYAKLE--KINAEQQLKIQELQEKLEKAVKA----------------------STEATELLQNIRQAKER 202
Cdd:PTZ00121 1419 kaDEAKKKAEEKKKADeaKKKAEEAKKADEAKKKAEEAKKAeeakkkaeeakkadeakkkaeeAKKADEAKKKAEEAKKK 1498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  203 AErELEKLQNREDSSEGIRK--------KLVEAEERRHSLENK----------VKRLETMERRENRLKDDIQTKSQQIQQ 264
Cdd:PTZ00121 1499 AD-EAKKAAEAKKKADEAKKaeeakkadEAKKAEEAKKADEAKkaeekkkadeLKKAEELKKAEEKKKAEEAKKAEEDKN 1577

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  265 MADKILE----LEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE---------AHE 331
Cdd:PTZ00121 1578 MALRKAEeakkAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkkkaeelkkAEE 1657

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  332 KGKILSEQKAMINAMDSK----IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 407
Cdd:PTZ00121 1658 ENKIKAAEEAKKAEEDKKkaeeAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 767972912  408 KLEEQLEKISH--QDHSDKNRLLELETRLREVSLEHEEQK 445
Cdd:PTZ00121 1738 EAEEDKKKAEEakKDEEEKKKIAHLKKEEEKKAEEIRKEK 1777
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 228-1018 4.62e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 84.40  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   228 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSQQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 300
Cdd:pfam15921   81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   301 IKVLDNQIKKDLADK-ETLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 353
Cdd:pfam15921  157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   354 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN--- 425
Cdd:pfam15921  237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   426 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 504
Cdd:pfam15921  317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   505 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 566
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   567 VDHLRREITEremqLTSQKQTMEALKTTctmleeqVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 646
Cdd:pfam15921  474 KEMLRKVVEE----LTAKKMTLESSERT-------VSDLTA---SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNE 539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   647 EKQSR-------------ARADQRITESRQVVEL-------------AVKEHKA----EILALQQALKEQKLKAESLSDK 696
Cdd:pfam15921  540 GDHLRnvqtecealklqmAEKDKVIEILRQQIENmtqlvgqhgrtagAMQVEKAqlekEINDRRLELQEFKILKDKKDAK 619

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   697 LNDLEKKHAMLEMNARSL----QQKLETERELKQrlleEQAKLQQQMDLQKNHIFRLTQGLqEALDR-----ADLLKTER 767
Cdd:pfam15921  620 IRELEARVSDLELEKVKLvnagSERLRAVKDIKQ----ERDQLLNEVKTSRNELNSLSEDY-EVLKRnfrnkSEEMETTT 694

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   768 SDLEYQLENIQ--------VLYSHE---------KVKMEGTISQQTKLIDFLQAKMD------QPAKKKKGLFSRRK--- 821
Cdd:pfam15921  695 NKLKMQLKSAQseleqtrnTLKSMEgsdghamkvAMGMQKQITAKRGQIDALQSKIQfleeamTNANKEKHFLKEEKnkl 774

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   822 --EDPALPTQVPLQYNELKLALEKE---KARCAELEEALQKT------------RIELRSAREEAAHR---KATDHP-HP 880
Cdd:pfam15921  775 sqELSTVATEKNKMAGELEVLRSQErrlKEKVANMEVALDKAslqfaecqdiiqRQEQESVRLKLQHTldvKELQGPgYT 854

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   881 STPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKERMHHnIPHRFNVGLNMRATKCAVCLDTV 959
Cdd:pfam15921  855 SNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQLLQE-LRSVINEEPTVQLSKAEDKGRAP 933

                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912   960 HFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYAThFTEAFCRDKMNSPGLQTKEPSS 1018
Cdd:pfam15921  934 SLGALDDRVRDCIIESSLRSDICHSSSNSLQTEGSK-SSETCSREPVLLHAGELEDPSS 991
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 62-857 1.07e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.19  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    62 VSQEDDKALQLLHDIREQSRKLQEIkeqeyQAQVEEMRLMMNQLEEDLVSARRRSDLyESELREsrlaaeefkRKATECQ 141
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERL-----DLIIDEKRQQLERLRREREKAERYQAL-LKEKRE---------YEGYELL 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   142 HKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ----------------------NIRQA 199
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKdlgeeeqlrvkekigeleaeiaSLERS 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   200 KERAERELEKLQNREDSSEG-IRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMA------------ 266
Cdd:TIGR02169  310 IAEKERELEDAEERLAKLEAeIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDkefaetrdelkd 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   267 --DKILELEEKHREAQVSAQHLEVHLKQKEQHYEE---KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKA 341
Cdd:TIGR02169  390 yrEKLEKLKREINELKRELDRLQEELQRLSEELADlnaAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQ 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   342 MINAMDSKIRSLEQRIVELS---EANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE-----QL 413
Cdd:TIGR02169  470 ELYDLKEEYDRVEKELSKLQrelAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRL 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   414 EKISHQDHSDKNRLLELETR----------LREVSLEHEEQKLELKRQLTELQLSLQERESQLtalqaaRAALESQLRQA 483
Cdd:TIGR02169  550 NNVVVEDDAVAKEAIELLKRrkagratflpLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY------EPAFKYVFGDT 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   484 KTELEETTAEAEEEIQALTAHRDEIQRK-------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA 556
Cdd:TIGR02169  624 LVVEDIEAARRLMGKYRMVTLEGELFEKsgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENR 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   557 NDEivqLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqvmDLEALNDELLEKERQWEAWRSVLGD---EKSQF 633
Cdd:TIGR02169  704 LDE---LSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE---DLSSLEQEIENVKSELKELEARIEEleeDLHKL 777

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   634 ECRVRELQRMLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARS 713
Cdd:TIGR02169  778 EEALNDLEARLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   714 LQQKLETERELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvKMEGTIS 793
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------RKIEELE 909

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972912   794 QQtklIDFLQAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 857
Cdd:TIGR02169  910 AQ---IEKKRKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 3-725 1.10e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.19  E-value: 1.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEAVLSQ--KEVELKASETQRSLLEQdLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEElnKKIKDLGEEEQLRVKEK-IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL 335

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    81 RKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK 160
Cdd:TIGR02169  336 AEIEELERE-----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDR 410

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   161 LEKINAEQQLKIQELQEKL----EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLEN 236
Cdd:TIGR02169  411 LQEELQRLSEELADLNAAIagieAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQR 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   237 KVKRLETMER------RENR-----LKDDIQTKSQQIQQMadkiLELEEKHREAQVSA--QHLEVHLKQKEQHYEEKIKV 303
Cdd:TIGR02169  491 ELAEAEAQARaseervRGGRaveevLKASIQGVHGTVAQL----GSVGERYATAIEVAagNRLNNVVVEDDAVAKEAIEL 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   304 LdnqiKKDLADKET---LENM--MQRHEEEAHEKGKI-----LSE-----QKA---------MINAMDS------KIR-- 351
Cdd:TIGR02169  567 L----KRRKAGRATflpLNKMrdERRDLSILSEDGVIgfavdLVEfdpkyEPAfkyvfgdtlVVEDIEAarrlmgKYRmv 642

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   352 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyletqaGKLEAQNRKLEEQLEKISHQDHSDKNRLLELE 431
Cdd:TIGR02169  643 TLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERL-------EGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   432 TRLREVSLEHE--EQKLE-LKRQLTELQLSLQERESQLTALQAARAALESQLrQAKTELEETTAEAEEEIQALTAHR--D 506
Cdd:TIGR02169  716 RKIGEIEKEIEqlEQEEEkLKERLEELEEDLSSLEQEIENVKSELKELEARI-EELEEDLHKLEEALNDLEARLSHSriP 794

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   507 EIQRKFDALRnscTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQ 586
Cdd:TIGR02169  795 EIQAELSKLE---EEVSRIEARLREI---EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEE 868

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVE 666
Cdd:TIGR02169  869 ELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPE 948

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912   667 LA-----VKEHKAEILALQQALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELK 725
Cdd:TIGR02169  949 EElsledVQAELQRVEEEIRALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
107-620 1.57e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.42  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  107 EDLVSARRRSDLYESELRESRLAAEEFKrKATECQHKLLKAKDQGKPEVgeyakLEKINaEQQLKIQELQEKLEKAVKAS 186
Cdd:PRK03918  158 DDYENAYKNLGEVIKEIKRRIERLEKFI-KRTENIEELIKEKEKELEEV-----LREIN-EISSELPELREELEKLEKEV 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  187 TEATELLQNIRQAKERAEREL-------EKLQNREDSSEGIRKKLVEAEERR---HSLENKVKRLETMER-------REN 249
Cdd:PRK03918  231 KELEELKEEIEELEKELESLEgskrkleEKIRELEERIEELKKEIEELEEKVkelKELKEKAEEYIKLSEfyeeyldELR 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  250 RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE------VHLKQKEQHYEEKIKVLDN--QIKKDLADK--ETLE 319
Cdd:PRK03918  311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKelekrlEELEERHELYEEAKAKKEEleRLKKRLTGLtpEKLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  320 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISELRQQKFY 394
Cdd:PRK03918  391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKRIEKELKE 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  395 LETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLSLQERESQ 465
Cdd:PRK03918  471 IEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKSLKKELEK 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  466 LTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEEQLNQLTE 534
Cdd:PRK03918  551 LEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEKELKKLEE 626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  535 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH--LRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDEL 612
Cdd:PRK03918  627 ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYeeLREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706


                  ....*...
gi 767972912  613 LEKERQWE 620
Cdd:PRK03918  707 EKAKKELE 714
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
197-789 2.11e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.03  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  197 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH 276
Cdd:PRK03918  144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  277 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKETLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 356
Cdd:PRK03918  224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  357 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLRE 436
Cdd:PRK03918  282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  437 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 511
Cdd:PRK03918  350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  512 FDALRNS------CTVITDLEEQLNQLTEDNAELNNqnfyLSKQLDEASganDEIVQLRSEVDHLRREItEREMQLTSQK 585
Cdd:PRK03918  428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKR----IEKELKEIE---EKERKLRKELRELEKVL-KKESELIKLK 499

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  586 QTMEALKTTCTMLEE-QVMDLEALNDE---LLEKERQWEAWRSVLGDE---KSQFECRVRELQRMLDTEKQSRARADQRI 658
Cdd:PRK03918  500 ELAEQLKELEEKLKKyNLEELEKKAEEyekLKEKLIKLKGEIKSLKKElekLEELKKKLAELEKKLDELEEELAELLKEL 579

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  659 TE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 731
Cdd:PRK03918  580 EElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEE 659

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  732 Q-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 789
Cdd:PRK03918  660 EyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 26-614 4.81e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.83  E-value: 4.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    26 ELKASETQRSLLEqdlatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQL 105
Cdd:TIGR04523  111 EIKNDKEQKNKLE-------VELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQ-----KEELENELNLL 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   106 EEDLvsARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAkdqgkpevgEYAKLEKINAEQQLKIQELQEKLEKAVKA 185
Cdd:TIGR04523  179 EKEK--LNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLES---------QISELKKQNNQLKDNIEKKQQEINEKTTE 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   186 STEATellQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRE--NRLKDDIQTKSQQIQ 263
Cdd:TIGR04523  248 ISNTQ---TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDwnKELKSELKNQEKKLE 324

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   264 QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvlDNQIKKDLADKETLENMMQRHEEEahekgkilseqkamI 343
Cdd:TIGR04523  325 EIQNQISQNNKIISQLNEQISQLKKELTNSESENSEK----QRELEEKQNEIEKLKKENQSYKQE--------------I 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   344 NAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 423
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQ--------------KDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVK 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   424 KNRLLELETrlrevSLEHEEQKLE--------LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleETTAEAE 495
Cdd:TIGR04523  453 ELIIKNLDN-----TRESLETQLKvlsrsinkIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLT----KKISSLK 523

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   496 EEIQALTAHRDEIQRKFDALRNSC-------------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQ 562
Cdd:TIGR04523  524 EKIEKLESEKKEKESKISDLEDELnkddfelkkenleKEIDEKNKEIEELKQTQKSLKKKQEEKQELID----------Q 593

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|..
gi 767972912   563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLE 614
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 50-812 5.75e-14

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 77.69  E-value: 5.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   50 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 127
Cdd:COG3096   289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  128 LAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ---LKIQELQEKLEKAvKASTEATELlqNIRQAKERAE 204
Cdd:COG3096   368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQtraIQYQQAVQALEKA-RALCGLPDL--TPENAEDYLA 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  205 RELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRlkddiqtksqqiQQMADKILELEEKHREAQVSAQ 284
Cdd:COG3096   445 AFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCKIAGEVER------------SQAWQTARELLRRYRSQQALAQ 512

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  285 ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 355
Cdd:COG3096   513 rlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRA 592

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  356 RIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKN 425
Cdd:COG3096   593 RIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQPGGAEDP 672

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  426 RLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ESQLTAL 469
Cdd:COG3096   673 RLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfdDSVFDAE 752

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  470 QAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtednaelnnqn 543
Cdd:COG3096   753 ELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF----------- 821

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  544 fyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTML---------------EEQVMDLE 606
Cdd:COG3096   822 --VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLnkllpqanlladetlADRLEELR 899

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  607 ALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHK 673
Cdd:COG3096   900 EELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDA 975

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  674 AEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHifrl 749
Cdd:COG3096   976 VGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADA---- 1051

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912  750 tqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 812
Cdd:COG3096  1052 -----EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 255-875 1.22e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 76.31  E-value: 1.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   255 IQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQR--HEEEAHE- 331
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNtvHELEAAKc 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   332 -KGKILSEQKAMINAMDSKIRSLE---QRI----VELSEAN--KLAANSSLFTQ--RNM-KAQEEMISELRQQKFYLETQ 398
Cdd:pfam15921  160 lKEDMLEDSNTQIEQLRKMMLSHEgvlQEIrsilVDFEEASgkKIYEHDSMSTMhfRSLgSAISKILRELDTEISYLKGR 239

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   399 AGKLEAQNRKLEEQLE---KISHQDHSDKNRLL----ELE-TRLREVSLEHEEQKLELKRQLTELQLSLQERES----QL 466
Cdd:pfam15921  240 IFPVEDQLEALKSESQnkiELLLQQHQDRIEQLisehEVEiTGLTEKASSARSQANSIQSQLEIIQEQARNQNSmymrQL 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   467 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTednAELNNQNFYL 546
Cdd:pfam15921  320 SDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQES---GNLDDQLQKLL---ADLHKREKEL 393

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   547 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWrsvL 626
Cdd:pfam15921  394 SLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQ---L 470

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   627 GDEKSQFECRVRELQ-RMLDTEKQSRARADqrITESRQVVELAVKEHKAEILALQQALkeqKLKAESLSDKLNDLEK-KH 704
Cdd:pfam15921  471 ESTKEMLRKVVEELTaKKMTLESSERTVSD--LTASLQEKERAIEATNAEITKLRSRV---DLKLQELQHLKNEGDHlRN 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   705 AMLEMNARSLQ--------QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS----DLEY 772
Cdd:pfam15921  546 VQTECEALKLQmaekdkviEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDakirELEA 625

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   773 QLENIQVlyshEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKglfSRRKEDPALPTqvplQYNELKLALekeKARCAELE 852
Cdd:pfam15921  626 RVSDLEL----EKVKLVNAGSERLRAVKDIKQERDQLLNEVK---TSRNELNSLSE----DYEVLKRNF---RNKSEEME 691

                          650       660
                   ....*....|....*....|...
gi 767972912   853 EALQKTRIELRSAREEAAHRKAT 875
Cdd:pfam15921  692 TTTNKLKMQLKSAQSELEQTRNT 714
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 167-790 1.30e-13

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 76.37  E-value: 1.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   167 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegirkkLVEAEERRHSLENKVKRLET--- 243
Cdd:pfam01576    6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEMRARLAARKQELEEilh 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   244 -MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:pfam01576   79 eLESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQlekVTTEAKIKKLEEDILLLEDQNSKLSKERKLLE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   320 ---NMMQRHEEEAHEKGKILSEQKAMINAMdskirsleqrIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 396
Cdd:pfam01576  159 eriSEFTSNLAEEEEKAKSLSKLKNKHEAM----------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   397 TQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLeheeQKLELKRQLTELQLSLQERESQLTALQAARAAL 476
Cdd:pfam01576  229 AQIAELRAQLAKKEEELQ--------------AALARLEEETA----QKNNALKKIRELEAQISELQEDLESERAARNKA 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   477 ESQLRqakteleettaeaeeeiqaltahrdeiqrkfdalrnsctvitDLEEQLNQLTEDnaelnnqnfyLSKQLDEASGA 556
Cdd:pfam01576  291 EKQRR------------------------------------------DLGEELEALKTE----------LEDTLDTTAAQ 318

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   557 NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCtmleeqvmdLEALNDELLEKER---QWEAWRSVLGDEKSQF 633
Cdd:pfam01576  319 QELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA---------LEELTEQLEQAKRnkaNLEKAKQALESENAEL 389

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   634 ECRVRELQRMLDTEKQSRARADQritesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNA 711
Cdd:pfam01576  390 QAELRTLQQAKQDSEHKRKKLEG------QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDV 463

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   712 RSLQQKLETERELKQRllEEQAKLQ-----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKV 786
Cdd:pfam01576  464 SSLESQLQDTQELLQE--ETRQKLNlstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKK 531


                   ....
gi 767972912   787 KMEG 790
Cdd:pfam01576  532 KLEE 535
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
3-566 1.33e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 76.23  E-value: 1.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:PRK02224  198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETR----DEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   83 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQhkllkakdqgkpevgeyakle 162
Cdd:PRK02224  274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELR--------------------- 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  163 kinaeqqlkiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLE 242
Cdd:PRK02224  328 ----------DRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELE---EEIE 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  243 TMERRENRLKDDIQtksqqiqQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADK 315
Cdd:PRK02224  395 ELRERFGDAPVDLG-------NAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHV 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  316 ETLENMMQRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELR 389
Cdd:PRK02224  468 ETIEEDRERVEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELR 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  390 QQKFYLETQAGKLEAQNRKLEEQ----------LEKISHQDHSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSL 459
Cdd:PRK02224  544 ERAAELEAEAEEKREAAAEAEEEaeeareevaeLNSKLAELKERIESLERIRTLLAAIA-DAEDEIERLREKREALAELN 622

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  460 QERESQLTALQAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQ 531
Cdd:PRK02224  623 DERRERLAEKRERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEE 695

                         570       580       590
                  ....*....|....*....|....*....|....*
gi 767972912  532 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE 566
Cdd:PRK02224  696 LRERREALENRVEALEALYDEAEELESMYGDLRAE 730
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
125-736 2.24e-13

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 75.46  E-value: 2.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  125 ESRLAAEEFKRKATECQHKLlKAKDQGKPEVGEYAKL---EKINAEQQLKIQELQEKLEKAVKASTEATELLqnirqakE 201
Cdd:PRK02224  173 DARLGVERVLSDQRGSLDQL-KAQIEEKEEKDLHERLnglESELAELDEEIERYEEQREQARETRDEADEVL-------E 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  202 RAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVK-----RLETMERRENRLKD------DIQTKSQQIQQMADKIL 270
Cdd:PRK02224  245 EHEERREELETLEAEIEDLRETIAETEREREELAEEVRdlrerLEELEEERDDLLAEaglddaDAEAVEARREELEDRDE 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  271 ELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKDLADKETLENMMQRHEEEahekgkiLSEQKAMINAMDSKI 350
Cdd:PRK02224  325 ELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEELREEAAELESELEEAREA-------VEDRREEIEELEEEI 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  351 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLEL 430
Cdd:PRK02224  394 EELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  431 EtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQR 510
Cdd:PRK02224  471 E--------EDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-EDRIERLEERREDLE-------ELIAERRETIEE 534

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  511 KfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 590
Cdd:PRK02224  535 K--------------RERAEELRERAAELE----------AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIES 590

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  591 LKTTCTMLEEqVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavk 670
Cdd:PRK02224  591 LERIRTLLAA-IADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYL------- 662

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  671 ehkaeilalqqalkeqklkaESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 736
Cdd:PRK02224  663 --------------------EQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
157-601 2.29e-13

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 75.19  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL----------VE 226
Cdd:COG4717    54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekllqllplyQE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  227 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSQQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 298
Cdd:COG4717   134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  299 EKIKVLDNQIKKDLADKETLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 376
Cdd:COG4717   213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  377 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREV-----SLEHEEQKLELKRQ 451
Cdd:COG4717   293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  452 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 517
Cdd:COG4717   369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  518 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 597
Cdd:COG4717   440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLALELLEEAREE 508


                  ....
gi 767972912  598 LEEQ 601
Cdd:COG4717   509 YREE 512
PRK01156 PRK01156
chromosome segregation protein; Provisional
 23-593 2.50e-13

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 75.32  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   23 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 100
Cdd:PRK01156  172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  101 MMNQLEEdlvSARRRSDLYESELRESRLAAEEFKRKATECQHKLL--KAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 178
Cdd:PRK01156  244 LSSLEDM---KNRYESEIKTAESDLSMELEKNNYYKELEERHMKIinDPVYKNRNYINDYFKYKNDIENKKQILSNIDAE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  179 LEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEErrhSLENKVKRLETMERRENRLKDDIQTK 258
Cdd:PRK01156  321 INKYHAIIKKLSVL-QKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLK---SIESLKKKIEEYSKNIERMSAFISEI 396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  259 SQQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEKIKVLDNQIK-----KDLADkETLENMMQRHE 326
Cdd:PRK01156  397 LKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgTTLGE-EKSNHIINHYN 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  327 EEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 404
Cdd:PRK01156  476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  405 QNRKLEeqlekISHQDHSDKNRLLELETRLREVSLEheEQKLELKRQLTELQLSLQERESQLTALQAAraaLESQLRQAK 484
Cdd:PRK01156  556 KSLKLE-----DLDSKRTSWLNALAVISLIDIETNR--SRSNEIKKQLNDLESRLQEIEIGFPDDKSY---IDKSIREIE 625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  485 TELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLR 564
Cdd:PRK01156  626 NEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD---AKANRARLE 701

                         570       580
                  ....*....|....*....|....*....
gi 767972912  565 SEVDHLRREITEREMQLTSQKQTMEALKT 593
Cdd:PRK01156  702 STIEILRTRINELSDRINDINETLESMKK 730
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 120-829 8.74e-13

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 73.60  E-value: 8.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   120 ESELRESRLAAEEfKRKATECQHKLLKAKDQGKpevgeyaklEKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--R 197
Cdd:pfam05483   98 EAELKQKENKLQE-NRKIIEAQRKAIQELQFEN---------EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaR 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   198 QAKERAERELEKLQNRE---DSSEGIRKKLVEAEERRHSLEN-------KVKR-LETMERRENRLKDDIQTKSQQIQQMA 266
Cdd:pfam05483  167 SAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAENarlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   267 DKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMqrhEEEAHEKGKILSEQKAMINAM 346
Cdd:pfam05483  247 IQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDL 319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   347 DSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ 419
Cdd:pfam05483  320 QIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   420 DHSDKNRLLELETRLREVSLEHEEQKL------ELKRQLTELQLSLQERES-------QLTALQAARAALESQLRQAKTE 486
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQELIFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   487 LEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSE 566
Cdd:pfam05483  480 LEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLELKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDE 549

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   567 VDHLRREIteremqltsqKQTMEALKTTCTMLEEQVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMldt 646
Cdd:pfam05483  550 LESVREEF----------IQKGDEVKCKLDKSEENARSIEY---EVLKKEKQMKILENKCNNLKKQIENKNKNIEEL--- 613

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   647 EKQSRARADQRITESRQvveLAVKEHKAEILALQQALKEQKLKaESLSDKLNDLEKKhamlemnaRSLQQKLETERELKQ 726
Cdd:pfam05483  614 HQENKALKKKGSAENKQ---LNAYEIKVNKLELELASAKQKFE-EIIDNYQKEIEDK--------KISEEKLLEEVEKAK 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   727 RLLEEQAKLQQQMDLQKNH-IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAK 805
Cdd:pfam05483  682 AIADEAVKLQKEIDKRCQHkIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQ 761

                          730       740
                   ....*....|....*....|....
gi 767972912   806 MDQPAKKKKGLFSRRKEDPALPTQ 829
Cdd:pfam05483  762 LEIEKEEKEKLKMEAKENTAILKD 785
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 67-771 9.25e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 73.46  E-value: 9.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    67 DKALQLLHDIREQSRKLqEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLK 146
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSL-HGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQ-KREAQE 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   147 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 226
Cdd:TIGR00618  254 EQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHI-KAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAA 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   227 AEERRHSLENKVKRLETMERRENRLKDDIQtKSQQIQQMADKILELEEKHREAQvsaQHLEvHLKQKEQHYEEKIKVLDN 306
Cdd:TIGR00618  333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHE-VATSIREISCQQHTLTQHIHTLQ---QQKT-TLTQKLQSLCKELDILQR 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   307 QIKKDLAdketlenmmqRHEEEAHEKGKILSEQKAMInamdskirsLEQRIVELSEAnklaansslFTQRnmKAQEEMIS 386
Cdd:TIGR00618  408 EQATIDT----------RTSAFRDLQGQLAHAKKQQE---------LQQRYAELCAA---------AITC--TAQCEKLE 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   387 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQL 466
Cdd:TIGR00618  458 KIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTY 537

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   467 TALQAARAALESQLrqakteleettAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYL 546
Cdd:TIGR00618  538 AQLETSEEDVYHQL-----------TSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEA 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   547 SKQLDEASGAndEIVQLRSEVDHLRREITERemqltsQKQTMEALKTTCtmleeqvmdLEALNDELLeKERQWEAWRSVL 626
Cdd:TIGR00618  607 EDMLACEQHA--LLRKLQPEQDLQDVRLHLQ------QCSQELALKLTA---------LHALQLTLT-QERVREHALSIR 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   627 GDEKSQFECRVRELQRMldtekQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAM 706
Cdd:TIGR00618  669 VLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ 743

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912   707 LEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 771
Cdd:TIGR00618  744 SLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 937-991 2.29e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 63.19  E-value: 2.29e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  937 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 991
Cdd:cd20821     1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
mukB PRK04863
chromosome partition protein MukB;
74-778 2.72e-12

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 72.30  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   74 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKATECQHKLL 145
Cdd:PRK04863  307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALRQQEKIERYQADLEELEERleEQNEVVEEADEQQEENEARAE 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  146 KAKDqgkpevgEYAKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRK 222
Cdd:PRK04863  387 AAEE-------EVDELKSQLADYQQALDVQQTRaiqYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE---ATE 456

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  223 KLVEAEERRHSLENKVKRLETMERRENRLKDDIqTKSQQIQQMADKILELEEKHREAQvSAQHLEVHLKQKEQHYEEKIK 302
Cdd:PRK04863  457 ELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEV-SRSEAWDVARELLRRLREQRHLAE-QLQQLRMRLSELEQRLRQQQR 534

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  303 V--LDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFT 374
Cdd:PRK04863  535 AerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALAR 614

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  375 QRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE--HEEQ 444
Cdd:PRK04863  615 LREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDV 694

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  445 KLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARAAL----ESQLRQAKTE 486
Cdd:PRK04863  695 SLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFP 774

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  487 LEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLR 564
Cdd:PRK04863  775 EVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAFEADP----EAELRQLN 843

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  565 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---------------EQVMDLEALNDELLEKER----------QW 619
Cdd:PRK04863  844 RRRVELERALADHESQEQQQRSQLEQAKEGLSALNrllprlnlladetlaDRVEEIREQLDEAEEAKRfvqqhgnalaQL 923

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  620 EAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILA----LQQALKEQKLKAES 692
Cdd:PRK04863  924 EPIVSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQ 999

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  693 LSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------LEEQAKLQQQmdlqknhifRLTQGLQ 754
Cdd:PRK04863 1000 ERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgAEERARARRD---------ELHARLS 1070

                         810       820
                  ....*....|....*....|....
gi 767972912  755 EALDRADLLKTERSDLEYQLENIQ 778
Cdd:PRK04863 1071 ANRSRRNQLEKQLTFCEAEMDNLT 1094
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 11-581 3.02e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.07  E-value: 3.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    11 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 86
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    87 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKATECQHKLLK--AKDQGKPEvgeyaKLEKI 164
Cdd:pfam15921  397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERqmAAIQGKNE-----SLEKV 463

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   165 NAeQQLKIQELQEKLEKAVKASTEATELLQNirqaKERAEREL-EKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLET 243
Cdd:pfam15921  464 SS-LTAQLESTKEMLRKVVEELTAKKMTLES----SERTVSDLtASLQEKERAIEATNAEITKLRSR---VDLKLQELQH 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   244 MERRENRLKdDIQTKSQQIQqmadkiLELEEKHREAQVSAQHLEVHLKQKEQHYEE--KIKVLDNQIKKDLADKEtLEnm 321
Cdd:pfam15921  536 LKNEGDHLR-NVQTECEALK------LQMAEKDKVIEILRQQIENMTQLVGQHGRTagAMQVEKAQLEKEINDRR-LE-- 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   322 mqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAG 400
Cdd:pfam15921  606 --------------LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVK 663

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   401 KLEAQNRKLEEQLEKishqdhsdknrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQ 479
Cdd:pfam15921  664 TSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVA 729

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   480 LRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASG 555
Cdd:pfam15921  730 MGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNK 787

                          570       580
                   ....*....|....*....|....*.
gi 767972912   556 ANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:pfam15921  788 MAGELEVLRSQERRLKEKVANMEVAL 813
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
409-869 3.06e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 71.61  E-value: 3.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  409 LEEQLEKISHQDHSDknRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 485
Cdd:PRK02224  192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  486 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 557
Cdd:PRK02224  269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  558 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 637
Cdd:PRK02224  349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  638 RELQRMLDTEKQSRARAD------------QRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN------D 699
Cdd:PRK02224  429 AELEATLRTARERVEEAEalleagkcpecgQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraedlvE 506

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  700 LEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 772
Cdd:PRK02224  507 AEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  773 QLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCAELE 852
Cdd:PRK02224  587 RIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKRELE 640

                         490
                  ....*....|....*...
gi 767972912  853 EALQKTRIE-LRSAREEA 869
Cdd:PRK02224  641 AEFDEARIEeAREDKERA 658
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 67-753 5.34e-12

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 71.15  E-value: 5.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    67 DKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKR--------KAT 138
Cdd:TIGR00618  200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARieelraqeAVL 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   139 ECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNiRQAKERAERELEKLQNREDSSE 218
Cdd:TIGR00618  280 EETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   219 -------GIRKKLVEAEERRHSLENKVKRLETMERRENRLKddiqTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLK 291
Cdd:TIGR00618  359 dahevatSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLC----KELDILQREQATIDTRTSAFRDLQGQLAHAKKQQE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKG--KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 369
Cdd:TIGR00618  435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQtkEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPN 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   370 SSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK 449
Cdd:TIGR00618  515 PARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITV 594

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   450 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 529
Cdd:TIGR00618  595 RLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKEL 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   530 NQLTEDN-AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL--E 606
Cdd:TIGR00618  675 LASRQLAlQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQarT 754

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   607 ALNDELLEKERQWEAWRSVL--GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALK 684
Cdd:TIGR00618  755 VLKARTEAHFNNNEEVTAALqtGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEE 831

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912   685 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 753
Cdd:TIGR00618  832 QFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 521-873 8.34e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 8.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   521 VITDLEEQLNQLtEDNAELNNQNFYLSKQLDEAsgandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 600
Cdd:TIGR02168  194 ILNELERQLKSL-ERQAEKAERYKELKAELREL-----ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   601 QvmdLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavKEHKAEIL 677
Cdd:TIGR02168  268 K---LEELRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELESK-----LDELAEEL 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   678 A-LQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrlleEQAKLQQQMDLQKNHIFRLTQGLQEA 756
Cdd:TIGR02168  340 AeLEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS-------KVAQLELQIASLNNEIERLEARLERL 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   757 LDRADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNE 836
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDA 479

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 767972912   837 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 873
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 102-777 3.30e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 68.66  E-value: 3.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   102 MNQLEEDLVSARRRSDLYESELresrlaaEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEK 181
Cdd:pfam01576    7 MQAKEEELQKVKERQQKAESEL-------KELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHE 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   182 AVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLveaEERRHSLENKVKRLE----TMERRENRLKDDIQT 257
Cdd:pfam01576   80 LESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKL---QLEKVTTEAKIKKLEedilLLEDQNSKLSKERKL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   258 KSQQIQQMADKILELEEKHR---------EAQVSaqHLEVHLKQKEQHYEEKIKV----------LDNQIKKDLADKETL 318
Cdd:pfam01576  157 LEERISEFTSNLAEEEEKAKslsklknkhEAMIS--DLEERLKKEEKGRQELEKAkrklegestdLQEQIAELQAQIAEL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   319 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEanklaansSLFTQRNMKAQEEmiselrQQKFYLETQ 398
Cdd:pfam01576  235 RAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQE--------DLESERAARNKAE------KQRRDLGEE 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   399 agkLEAQNRKLEEQLEKISHQDHSDKNR---LLELETRLREVSLEHEEQKLELKR----QLTELQLSLQERESQLTALQA 471
Cdd:pfam01576  301 ---LEALKTELEDTLDTTAAQQELRSKReqeVTELKKALEEETRSHEAQLQEMRQkhtqALEELTEQLEQAKRNKANLEK 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   472 ARAALESQ----------LRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdalrnsctVITDLEEQLNQLTednAELNN 541
Cdd:pfam01576  378 AKQALESEnaelqaelrtLQQAKQDSEHKRKKLEGQLQELQARLSESER----------QRAELAEKLSKLQ---SELES 444

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   542 QNFYLSKQLDEASGANDEIVQLRSE---VDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVmdlealnDELLEKERQ 618
Cdd:pfam01576  445 VSSLLNEAEGKNIKLSKDVSSLESQlqdTQELLQEETRQKLNLSTRLRQLEDERNS---LQEQL-------EEEEEAKRN 514

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   619 WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvELAVKEHKAEILA-----LQQALKEQKLKAESL 693
Cdd:pfam01576  515 VERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQ--QLEEKAAAYDKLEktknrLQQELDDLLVDLDHQ 592

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   694 SDKLNDLEKKHamlemnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 773
Cdd:pfam01576  593 RQLVSNLEKKQ-------KKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAE 665


                   ....
gi 767972912   774 LENI 777
Cdd:pfam01576  666 MEDL 669
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
104-536 3.97e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 67.87  E-value: 3.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  104 QLEEDLVSARRRSDLY---ESELRESRLAAEEFKRKATECQHKL--LKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 178
Cdd:COG4717    75 ELEEELKEAEEKEEEYaelQEELEELEEELEELEAELEELREELekLEKLLQLLPLYQELEALEAELAELPERLEELEER 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  179 LEKAVKASTEATELLQNIRQAKERAERELEKLqnredsSEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTK 258
Cdd:COG4717   155 LEELRELEEELEELEAELAELQEELEELLEQL------SLATEEELQDLAEELEELQQRLAEL---EEELEEAQEELEEL 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  259 SQQIQQMADKILELEEKHR-------------------------------------EAQVSAQHLEVHLKQKEQHYEEKI 301
Cdd:COG4717   226 EEELEQLENELEAAALEERlkearlllliaaallallglggsllsliltiagvlflVLGLLALLFLLLAREKASLGKEAE 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  302 KVLDNQIKKDLADKEtLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 381
Cdd:COG4717   306 ELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDE 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  382 EEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 460
Cdd:COG4717   385 EELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEELEEELEELEEELEELREELAELEAELE 463

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912  461 ERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctVITDLEEQLNQLTEDN 536
Cdd:COG4717   464 QLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP---------VLERASEYFSRLTDGR 532
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 935-992 7.34e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.34e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  935 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 992
Cdd:cd20823     1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1192-1443 8.45e-11

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 67.22  E-value: 8.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1192 SDQVVLVGTEEGLYALNVLKNS--------LTHVPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1263
Cdd:COG5422   868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1264 aqpDISPNIFEAVK-----GCHLFGAGKiENGLCICAAMPSKVVILRYN------ENLSKYCIRKEIETSEPCScIHFTN 1332
Cdd:COG5422   944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNksgnlkKALTIELSTELYVPSEPLS-VHFLK 1018

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1333 YSILIGTNKFYEI-DMKQYTLEEFLDKNDHSlaPAVFAASSNSFPVSIVQVNSagqreEYLLCFHEFGVFVDSYGRRSRT 1411
Cdd:COG5422  1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                         250       260       270
                  ....*....|....*....|....*....|...
gi 767972912 1412 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1443
Cdd:COG5422  1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 200-874 8.57e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.02  E-value: 8.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   200 KERAERELEKLQNREDSSEGIRKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE 274
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   275 khreaqvSAQHLEVHLKQKEQHYEEKIKVLDnqikkdladkETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE 354
Cdd:TIGR02169  252 -------ELEKLTEEISELEKRLEEIEQLLE----------ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKE 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   355 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:TIGR02169  315 RELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKL 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   435 REVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQlrqakteleettaeaeeeIQALTAHRDEIQRKfda 514
Cdd:TIGR02169  395 EKLKREIN----ELKRELDRLQEELQRLSEELADLNAAIAGIEAK------------------INELEEEKEDKALE--- 449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   515 lrnsctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 594
Cdd:TIGR02169  450 -------IKKQEWKLEQLAADLSKYEQELYDLKEEYD----------RVEKELSKLQRELAEAEAQARASEERVRGGRAV 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   595 CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF----------EC----RVRELQRM--LDTEKQSRARADQRI 658
Cdd:TIGR02169  513 EEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNvvveddavakEAiellKRRKAGRAtfLPLNKMRDERRDLSI 592

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   659 TESRQVVELAV-------KEHKAEILALQQALKEQKLKAE----------SLSDKLndLEKKHAM---------LEMNAR 712
Cdd:TIGR02169  593 LSEDGVIGFAVdlvefdpKYEPAFKYVFGDTLVVEDIEAArrlmgkyrmvTLEGEL--FEKSGAMtggsraprgGILFSR 670

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   713 SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-------LDRADLLKTERSDLEYQLENIQVLYSHEK 785
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAsrkigeiEKEIEQLEQEEEKLKERLEELEEDLSSLE 750

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   786 VKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS-RRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRS 864
Cdd:TIGR02169  751 QEIENVKSELKELEARIEELEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEY 830

                          730
                   ....*....|
gi 767972912   865 AREEAAHRKA 874
Cdd:TIGR02169  831 LEKEIQELQE 840
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 3-773 1.09e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 66.99  E-value: 1.09e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQdlatyITECSSLKRSLEQARMEVSQEDDkALQLLHDIREQ 79
Cdd:TIGR00606  318 ERELVDCQRELEKLNKerrLLNQEKTELLVEQGRLQLQAD-----RHQEHIRARDSLIQSLATRLELD-GFERGPFSERQ 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYA 159
Cdd:TIGR00606  392 IKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSD 471

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   160 KLEKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 238
Cdd:TIGR00606  472 RILELDQELRKAERELSKAEKNSLTETLKKEVKsLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI 551

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   239 KRLETMERRE-----------NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQH---YEEKIKvl 304
Cdd:TIGR00606  552 RKIKSRHSDEltsllgyfpnkKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQlssYEDKLF-- 629

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   305 dnqikkDLADKETLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR00606  630 ------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEF 696

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   385 ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN-------RLLELETRLREVSLEHEEQKLELKRQLTELQL 457
Cdd:TIGR00606  697 ISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSiidlkekEIPELRNKLQKVNRDIQRLKNDIEEQETLLGT 776

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   458 SLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC----TVITDLE 526
Cdd:TIGR00606  777 IMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQ 856

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   527 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEalkttctmleeqvmDLE 606
Cdd:TIGR00606  857 EQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLE--------------KDQ 922

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   607 ALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKAEILALQQALKEQ 686
Cdd:TIGR00606  923 QEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKETELNTVNAQLEEC 989

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   687 KLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQAKLQQQMDLQKNH 745
Cdd:TIGR00606  990 EKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRN 1069

                          810       820
                   ....*....|....*....|....*...
gi 767972912   746 IFRLTQGLQEALDRADLLKTERSDLEYQ 773
Cdd:TIGR00606 1070 HVLALGRQKGYEKEIKHFKKELREPQFR 1097
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 7-740 1.16e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 66.74  E-value: 1.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     7 TRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQarmevSQEDDKALQLLHDIREQS----RK 82
Cdd:pfam01576  260 NNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELED-----TLDTTAAQQELRSKREQEvtelKK 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    83 LQEIKEQEYQAQVEEMRLMMNQ----LEEDLVSARR-RSDL------YESELRESRLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:pfam01576  335 ALEEETRSHEAQLQEMRQKHTQaleeLTEQLEQAKRnKANLekakqaLESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   152 KPEVGEYAKLEKINAEQQLKIQELQEKLE-----------KAVKASTEATEL------LQNIRQAKERAEREL-EKLQNR 213
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKLQSELEsvssllneaegKNIKLSKDVSSLesqlqdTQELLQEETRQKLNLsTRLRQL 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   214 EDSSEGIRKKLVEAEERRHSLENKVKRL------------------ETMERRENRLKDDIQTKSQQIQQMADKILELEEK 275
Cdd:pfam01576  495 EDERNSLQEQLEEEEEAKRNVERQLSTLqaqlsdmkkkleedagtlEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKT 574

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   276 HREAQVSAQHLEVHLKQKEQ---HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK-GKILSEQKAMINAMDSKir 351
Cdd:pfam01576  575 KNRLQQELDDLLVDLDHQRQlvsNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKeTRALSLARALEEALEAK-- 652

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   352 sleqriVELSEANKL--AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhSDKNRLLE 429
Cdd:pfam01576  653 ------EELERTNKQlrAEMEDLVSSKDDVGKN--VHELERSKRALEQQVEEMKTQLEELEDELQ-------ATEDAKLR 717

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   430 LETRLREVSLEH-----------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEI 498
Cdd:pfam01576  718 LEVNMQALKAQFerdlqardeqgEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAV 797

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   499 QAL---TAHRDEIQRKFDALRNSCTVI-----------TDLEEQLNQLTEDNA------------------ELNNQNFYL 546
Cdd:pfam01576  798 KQLkklQAQMKDLQRELEEARASRDEIlaqskesekklKNLEAELLQLQEDLAaserarrqaqqerdeladEIASGASGK 877

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   547 SKQLDEASGANDEIVQLRSEVDHLRREI---TEREMQLTSQKQTME----ALKTTCTMLEEQVMDLEALNDELLEKERQW 619
Cdd:pfam01576  878 SALQDEKRRLEARIAQLEEELEEEQSNTellNDRLRKSTLQVEQLTtelaAERSTSQKSESARQQLERQNKELKAKLQEM 957

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   620 E-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvvelavKEHKAEILALQqaLKEQKLKAESLSDKLn 698
Cdd:pfam01576  958 EgTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRR---------TEKKLKEVLLQ--VEDERRHADQYKDQA- 1025

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 767972912   699 dlEKKHAMLemnaRSLQQKLETERELKQRLLEEQAKLQQQMD 740
Cdd:pfam01576 1026 --EKGNSRM----KQLKRQLEEAEEEASRANAARRKLQRELD 1061
PRK01156 PRK01156
chromosome segregation protein; Provisional
 249-743 1.28e-10

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 66.46  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  249 NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKETLENMMQRHEEE 328
Cdd:PRK01156  186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  329 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 408
Cdd:PRK01156  258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  409 LEE------QLEKISHQDHSDKNRLLELET----------RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 472
Cdd:PRK01156  331 LSVlqkdynDYIKKKSRYDDLNNQILELEGyemdynsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  473 RAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYLS 547
Cdd:PRK01156  411 LNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKIR 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  548 KQLDEASGANDEIVQLRSEVDHLR-----------REITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKE 616
Cdd:PRK01156  487 EIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSK 566

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  617 R-QW------------EAWRSVLGDEKSQF---ECRVRELQ--------------RMLDTE------KQSRARADQRITE 660
Cdd:PRK01156  567 RtSWlnalavislidiETNRSRSNEIKKQLndlESRLQEIEigfpddksyidksiREIENEannlnnKYNEIQENKILIE 646

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  661 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQ 736
Cdd:PRK01156  647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETLE 726


                  ....*..
gi 767972912  737 QQMDLQK 743
Cdd:PRK01156  727 SMKKIKK 733
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 939-987 1.77e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.77e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 767972912    939 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 987
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 939-987 1.88e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.53  E-value: 1.88e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767972912  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd00029     1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
327-778 2.03e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 66.09  E-value: 2.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  327 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 403
Cdd:COG4913   238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  404 AQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 479
Cdd:COG4913   316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  480 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 538
Cdd:COG4913   396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  539 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREI-TEREMQLTSQKQTMEALKTTctmleeqvmdle 606
Cdd:COG4913   476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLvYERVRTGLPDPERPRLDPDS------------ 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  607 aLNDELLEKERQWEAW-RSVLGDEKSqFEC--RVRELQR---------MLDTEKQSRARADQRITESRQV----VELAVK 670
Cdd:COG4913   536 -LAGKLDFKPHPFRAWlEAELGRRFD-YVCvdSPEELRRhpraitragQVKGNGTRHEKDDRRRIRSRYVlgfdNRAKLA 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  671 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM---------NARSLQQKLETERELKQRLLEEQ---AKLQQQ 738
Cdd:COG4913   614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLDASSddlAALEEQ 693

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 767972912  739 MDlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:COG4913   694 LE-------ELEAELEELEEELDELKGEIGRLEKELEQAE 726
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2-417 3.25e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.04  E-value: 3.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 81
Cdd:TIGR04523  216 LESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKS 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    82 KLQEIKEQEYQAqveemrlMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQhKLLKAKDQGKPEVGEYAKl 161
Cdd:TIGR04523  296 EISDLNNQKEQD-------WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLK-KELTNSESENSEKQRELE- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   162 EKINAEQQLKiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRL 241
Cdd:TIGR04523  367 EKQNEIEKLK-KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   242 E----TMERRENRLKDDIQTKSQQIQQMADKI----LELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLA 313
Cdd:TIGR04523  446 TnqdsVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKELK-KLNEEKKELEEKVKDLTKKISSLKE 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   314 DKETLENmmqrheeEAHEKGKILSEQKAMINAMDS---------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 384
Cdd:TIGR04523  525 KIEKLES-------EKKEKESKISDLEDELNKDDFelkkenlekEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKE 597

                          410       420       430
                   ....*....|....*....|....*....|...
gi 767972912   385 ISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 417
Cdd:TIGR04523  598 KKDLIKEIEEKEKKISSLEKELEKAKKENEKLS 630
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
267-752 3.39e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.79  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  267 DKILELEEKHREAQVSAQHLEVHLKQKEQhYEEKIKVLDNQIKKDLADKETLENMMQRHEeeAHEKGKILSEQkamINAM 346
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEE-LEEELEELEAELEELREELEKLEKLLQLLP--LYQELEALEAE---LAEL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  347 DSKIRSLEQRIVELSEankLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNR 426
Cdd:COG4717   145 PERLEELEERLEELRE---LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  427 LLELETRLREVSLEHEEQKLElkRQLTELQLSLqeresqltALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:COG4717   222 LEELEEELEQLENELEAAALE--ERLKEARLLL--------LIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFL 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  507 EIQRKFDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREitEREMQLTSQK 585
Cdd:COG4717   292 LLAREKASLGKEAEELQALPALEElEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEEL--EEELQLEELE 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  586 QTMEALkttctMLEEQVMDLEALNdELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD-QRITESRQV 664
Cdd:COG4717   370 QEIAAL-----LAEAGVEDEEELR-AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEElEELEEELEE 443

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  665 VELAVKEHKAEILALQQALK---------EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAkl 735
Cdd:COG4717   444 LEEELEELREELAELEAELEqleedgelaELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA-- 521

                         490
                  ....*....|....*...
gi 767972912  736 qqqmdlqkNHIF-RLTQG 752
Cdd:COG4717   522 --------SEYFsRLTDG 531
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
65-663 5.02e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.55  E-value: 5.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   65 EDDKALQLLHDIreQSRK----LQE-IKEQ-----EYQAQVEEMRLMMNQL---EEDLVSARRRSDLyeseLRESRLAAE 131
Cdd:COG4913   189 GSEKALRLLHKT--QSFKpigdLDDfVREYmleepDTFEAADALVEHFDDLeraHEALEDAREQIEL----LEPIRELAE 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  132 EFKRKATECQHklLKAkdqgkpeVGEYAKLEkinaEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ 211
Cdd:COG4913   263 RYAAARERLAE--LEY-------LRAALRLW----FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELE 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  212 NREDSSEGIRKKLVEAEerrhsLENKVKRLETMERRENRLKDDIQT--------------KSQQIQQMADKILELEEKHR 277
Cdd:COG4913   330 AQIRGNGGDRLEQLERE-----IERLERELEERERRRARLEALLAAlglplpasaeefaaLRAEAAALLEALEEELEALE 404

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  278 EAQVSAQHLEVHLKQKEQHYEEKIKVLDN--------------QIKKDLADKET----LENMMQRHEEEAHEKGKI---- 335
Cdd:COG4913   405 EALAEAEAALRDLRRELRELEAEIASLERrksniparllalrdALAEALGLDEAelpfVGELIEVRPEEERWRGAIervl 484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  336 -------------LSEQKAMINAMDSKIR------------SLEQRIVELSEANKLAANSSLFTQRnmkAQEEM------ 384
Cdd:COG4913   485 ggfaltllvppehYAAALRWVNRLHLRGRlvyervrtglpdPERPRLDPDSLAGKLDFKPHPFRAW---LEAELgrrfdy 561

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  385 -----ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSdknrlleletRLREVSL---EHEEQKLELKRQLTELQ 456
Cdd:COG4913   562 vcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR----------RIRSRYVlgfDNRAKLAALEAELAELE 623

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  457 LSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQALTAHRDEIQRKFDALRNsctvITDLEEQLNQLTEDN 536
Cdd:COG4913   624 EELAEAEERLEALEAELDALQERREA---------------LQRLAEYSWDEIDVASAERE----IAELEAELERLDASS 684

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  537 AELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEke 616
Cdd:COG4913   685 DDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR---LEAAEDLARLELRALLE-- 752

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*...
gi 767972912  617 rqwEAWRSVLGDEKSQfecRVRE-LQRMLDTEKQSRARADQRITESRQ 663
Cdd:COG4913   753 ---ERFAAALGDAVER---ELREnLEERIDALRARLNRAEEELERAMR 794
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
318-554 5.25e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 64.27  E-value: 5.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  318 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 397
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  398 QAGKLEAQNRKLEEQLEKISHQ--DHSDKNRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 475
Cdd:COG3206   234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  476 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 554
Cdd:COG3206   303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
3-436 5.81e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLAtyitecsSLKRSLEqarmevsqEDDKALQLLHDIREQ 79
Cdd:PRK03918  313 EKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRLE-------ELEERHE--------LYEEAKAKKEELERL 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEC--------QHKLLKAKDQG 151
Cdd:PRK03918  378 KKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCpvcgreltEEHRKELLEEY 457

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER----ELEKLQNREDSSEGIRKKLVEA 227
Cdd:PRK03918  458 TAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKlkkyNLEELEKKAEEYEKLKEKLIKL 537

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  228 EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvSAQHLEVHLKQKEQHYEEKIKVLDnq 307
Cdd:PRK03918  538 KGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFE------SVEELEERLKELEPFYNEYLELKD-- 609

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  308 IKKDLadkETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISE 387
Cdd:PRK03918  610 AEKEL---EREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEE 684

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 767972912  388 LRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhSDKNRLLELETRLRE 436
Cdd:PRK03918  685 LEKRREEIKKTLEKLKEELEEREKAKKEL-----EKLEKALERVEELRE 728
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
409-869 5.91e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.02  E-value: 5.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  409 LEEQLEKISHQDHSDKNRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 487
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  488 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgANDEIVQLRSEV 567
Cdd:COG4717   126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA--TEEELQDLAEEL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  568 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNdELLEKERQWEAWRSVL-----GDEKSQFECRVRELQR 642
Cdd:COG4717   202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLallglGGSLLSLILTIAGVLF 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  643 MLdtekqSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE--MNARSLQQKLET 720
Cdd:COG4717   281 LV-----LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEllDRIEELQELLRE 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  721 ERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI-----QVLYSHEKVKMEG 790
Cdd:COG4717   356 AEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgeleELLEALDEEELEE 432

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  791 TISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE---ALQKTRIELRSARE 867
Cdd:COG4717   433 ELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewaALKLALELLEEARE 507


                  ..
gi 767972912  868 EA 869
Cdd:COG4717   508 EY 509
PTZ00121 PTZ00121
MAEBL; Provisional
 81-876 6.14e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.39  E-value: 6.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   81 RKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLKAKDQGKPEVGEYAK 160
Cdd:PTZ00121 1027 EKIEELTEYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKE-DNRADEATEEAFGKAEEAKK 1105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  161 LEKINAEQQLKIQELQEKLEKAVKAstEATELLQNIRQAKE--RAE--RELEKLQNREDSSEGIRKKLVE----AEERRH 232
Cdd:PTZ00121 1106 TETGKAEEARKAEEAKKKAEDARKA--EEARKAEDARKAEEarKAEdaKRVEIARKAEDARKAEEARKAEdakkAEAARK 1183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  233 SLEnkVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQhlEVHLKQKEQHYEEKIKVLDNQIKKDL 312
Cdd:PTZ00121 1184 AEE--VRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAE--EAKKDAEEAKKAEEERNNEEIRKFEE 1259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKiRSLEQRIVElsEANKLAANSSLFTQRNMKAQEemiSELRQQK 392
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK-KAEEKKKAD--EAKKKAEEAKKADEAKKKAEE---AKKKADA 1333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  393 FYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 472
Cdd:PTZ00121 1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA 1413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  473 RAAlESQLRQAKTELEETTAEAEEEIQALTAHR-DEIQRKFDALRNSctvitdleEQLNQLTEDnaelnnqnfylSKQLD 551
Cdd:PTZ00121 1414 AAA-KKKADEAKKKAEEKKKADEAKKKAEEAKKaDEAKKKAEEAKKA--------EEAKKKAEE-----------AKKAD 1473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  552 EASGANDEivqlRSEVDHLRREITEREMQLTSQKQTMEALKTTctmleeqvmdlealnDELLEKERQWEAWRSVLGDEKS 631
Cdd:PTZ00121 1474 EAKKKAEE----AKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------------DEAKKAEEAKKADEAKKAEEAK 1534

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  632 QFEcrvrELQRMLDTEKQSRARADQRITESRQV--VELAVKEHKAEILALQQAlkeqklkaeslsDKLNDLEKKHAMLEM 709
Cdd:PTZ00121 1535 KAD----EAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKA------------EEAKKAEEARIEEVM 1598

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  710 NARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 789
Cdd:PTZ00121 1599 KLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE 1678

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  790 gtisqqtklidflQAKMDQPAKKKKGLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL--EEALQKTRIELRSARE 867
Cdd:PTZ00121 1679 -------------EAKKAEEDEKKAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEA 1739


                  ....*....
gi 767972912  868 EAAHRKATD 876
Cdd:PTZ00121 1740 EEDKKKAEE 1748
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1-456 8.61e-10

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 63.91  E-value: 8.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARMEVSQEDDKAL---Q 71
Cdd:TIGR00606  588 QTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSKQRAMLAGATAvysQ 667

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    72 LLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAtECQHKLLKAKDQG 151
Cdd:TIGR00606  668 FITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA-PGRQSIIDLKEKE 745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   152 KPEVGEyaKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE-------LLQNIRQAKERAERELEKLQNREDSSEGIRK 222
Cdd:TIGR00606  746 IPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdvtIMERFQMELKDVERKIAQQAAKLQGSDLDRT 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   223 klveAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQVSAQHLEVHLKQKEQHYEE 299
Cdd:TIGR00606  824 ----VQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKlqiGTNLQRRQQFEEQLVELSTEVQS 899

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   300 KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI-------RSLEQRIVE---------LSEA 363
Cdd:TIGR00606  900 LIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVknihgymKDIENKIQDgkddylkqkETEL 979

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   364 NKLAANSSLFTQRNMKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLE-------L 430
Cdd:TIGR00606  980 NTVNAQLEECEKHQEKINEDMrlmrqdIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQmkqehqkL 1059

                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 767972912   431 ETRLREVSLEH----------EEQKLELKRQLTELQ 456
Cdd:TIGR00606 1060 EENIDLIKRNHvlalgrqkgyEKEIKHFKKELREPQ 1095
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
75-675 1.23e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   75 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 154
Cdd:COG4913   263 RYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQ 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  155 V-GEYAKLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQNIRQAKERAER---ELEKLQNREDSsegIRKKLVEAEE 229
Cdd:COG4913   343 LeREIERLERELEERERRRARLEALLAALgLPLPASAEEFAALRAEAAALLEAleeELEALEEALAE---AEAALRDLRR 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  230 RRHSLENKVKRLE----TMERRENRLKDDIqtkSQQIQQMADKI------LELEEKHREAQ---------------VSAQ 284
Cdd:COG4913   420 ELRELEAEIASLErrksNIPARLLALRDAL---AEALGLDEAELpfvgelIEVRPEEERWRgaiervlggfaltllVPPE 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  285 HL--------EVHLKQK-------------------EQHYEEKIKVLDNQ----IKKDLADK------ETLENM------ 321
Cdd:COG4913   497 HYaaalrwvnRLHLRGRlvyervrtglpdperprldPDSLAGKLDFKPHPfrawLEAELGRRfdyvcvDSPEELrrhpra 576

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  322 -----MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSLEQRIVELSEANKLAANSslftQRNMKAQEEMISE 387
Cdd:COG4913   577 itragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAE----LDALQERREALQR 652

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  388 LRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLREVSLEH---EEQKLELKRQLTELQLSLQERES 464
Cdd:COG4913   653 LAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQLEELEAELeelEEELDELKGEIGRLEKELEQAEE 727

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  465 QLTALQAA------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRN------------SCT 520
Cdd:COG4913   728 ELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE-ERIDALRARLNRAEEELERamrafnrewpaeTAD 806

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  521 VITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER----------------- 577
Cdd:COG4913   807 LDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKERidplndslkripfgpgr 882

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  578 EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKerqweawrsvlgdeksQFEcRVREL-QRMLDTEKQSRARADQ 656
Cdd:COG4913   883 YLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEA----------------RFA-ALKRLiERLRSEEEESDRRWRA 945

                         730
                  ....*....|....*....
gi 767972912  657 RITESRQVVELAVKEHKAE 675
Cdd:COG4913   946 RVLDVRNHLEFDAEEIDRE 964
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 71-365 1.96e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 62.45  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    71 QLLHDIREQsRKLQEIKEQEYQAQVEEMRLMMNQlEEDLVSARRRSDLYESEL-------RESRLAAEEfKRKATECQHK 143
Cdd:pfam17380  273 QLLHIVQHQ-KAVSERQQQEKFEKMEQERLRQEK-EEKAREVERRRKLEEAEKarqaemdRQAAIYAEQ-ERMAMERERE 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   144 LLKAKDQGKP-------------EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATE----------LLQNIRQAK 200
Cdd:pfam17380  350 LERIRQEERKrelerirqeeiamEISRMRELERLQMERQQKNERVRQELEAARKVKILEEErqrkiqqqkvEMEQIRAEQ 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   201 ERA-ERELEKLQN-REDSSEGIRKklvEAEERRHSLEnKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHRE 278
Cdd:pfam17380  430 EEArQREVRRLEEeRAREMERVRL---EEQERQQQVE-RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERK 505

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   279 AQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDsKIRSLEQRIV 358
Cdd:pfam17380  506 QAMIEEERKRKLLEKEM--EERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAME-REREMMRQIV 582


                   ....*..
gi 767972912   359 ELSEANK 365
Cdd:pfam17380  583 ESEKARA 589
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 26-480 2.57e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.05  E-value: 2.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    26 ELKASETQRSLLEQDLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqL 105
Cdd:pfam05483  339 ELNKAKAAHSFVVTEFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------L 407

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   106 EE-DLVSARRRSDLYESELRESrlAAEEFKRKATECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLK-IQELQEKLEKAV 183
Cdd:pfam05483  408 EElKKILAEDEKLLDEKKQFEK--IAEELKGKEQELIF-LLQAREKEIHDLEIQLTAIKTSEEHYLKeVEDLKTELEKEK 484

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   184 KASTEATE-----LLQNIRQAKERAERELEKLQNREDSSEGIRKKlveaeerrhslENKVKRLETMERRENRLKDDIQTK 258
Cdd:pfam05483  485 LKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENLEEKEMNLRDELESV 553

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   259 SQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEtlENMMQRHEEEAHEKGKILSE 338
Cdd:pfam05483  554 REEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEELHQENKALKKKGSAE 627

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   339 QKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLEAQNR-KLEEQLEKI 416
Cdd:pfam05483  628 NKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAIADEAvKLQKEIDKR 697

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972912   417 SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ-ERESQLTALQAARAALESQL 480
Cdd:pfam05483  698 CQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKaALEIELSNIKAELLSLKKQL 762
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 3-231 2.66e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.93  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 82
Cdd:COG4942    26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   83 LQE-IKEQEYQAQVEEMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKATEcqhklLKAKDQgkpevgeyaKL 161
Cdd:COG4942   106 LAElLRALYRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE-----LAALRA---------EL 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  162 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERR 231
Cdd:COG4942   170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
PTZ00121 PTZ00121
MAEBL; Provisional
 21-416 3.42e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   21 SQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALqllhdiREQSRKLQEIKEQEYQAQVEEMRL 100
Cdd:PTZ00121 1521 AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK------KAEEDKNMALRKAEEAKKAEEARI 1594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  101 MMNQLEEDLVSARRRSDLYESElrESRLAAEEFkRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLE 180
Cdd:PTZ00121 1595 EEVMKLYEEEKKMKAEEAKKAE--EAKIKAEEL-KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  181 KAVKASTEATELLQNIRQA------KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERR---ENRL 251
Cdd:PTZ00121 1672 EDKKKAEEAKKAEEDEKKAaealkkEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKkaeEAKK 1751

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  252 KDDIQTKSQQIQQMADKILELEEKHREAqVSAQHLEVHLKQKEQHYEEKIK-VLDN---------------QIKKDLADK 315
Cdd:PTZ00121 1752 DEEEKKKIAHLKKEEEKKAEEIRKEKEA-VIEEELDEEDEKRRMEVDKKIKdIFDNfaniieggkegnlviNDSKEMEDS 1830

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  316 ETLE----NMMQRHEEEAHEKGKIL--------SEQKAMINAMDSKIRSLEQRIVELSEANKLAAN--SSLFTQRNMKAQ 381
Cdd:PTZ00121 1831 AIKEvadsKNMQLEEADAFEKHKFNknnengedGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDdiEREIPNNNMAGK 1910

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 767972912  382 EEMIselrqqkfyLETQAGKLEAQNRKLEEQLEKI 416
Cdd:PTZ00121 1911 NNDI---------IDDKLDKDEYIKRDAEETREEI 1936
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 4-465 3.71e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 61.67  E-value: 3.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     4 QEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQARMEV-----------SQEDDKALQ 71
Cdd:pfam15921  370 QESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRNMEVqrleallkamkSECQGQMER 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    72 LLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLV--------SARRRSDLYESeLRESRLAAEEFKRKAT----- 138
Cdd:pfam15921  449 QMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTakkmtlesSERTVSDLTAS-LQEKERAIEATNAEITklrsr 525

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   139 ------ECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK-----ASTEATELLQNIRQAKERAEREL 207
Cdd:pfam15921  526 vdlklqELQH-LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqhGRTAGAMQVEKAQLEKEINDRRL 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   208 EkLQNREDSSEGIRKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVsaqhL 286
Cdd:pfam15921  605 E-LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEV----L 679

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   287 EVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 366
Cdd:pfam15921  680 KRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTN 759

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   367 AANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsdknRLLELETRLREVSLEHEEQKL 446
Cdd:pfam15921  760 ANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE--------------KVANMEVALDKASLQFAECQD 825

                          490       500
                   ....*....|....*....|....
gi 767972912   447 ELKRQLTE-----LQLSLQERESQ 465
Cdd:pfam15921  826 IIQRQEQEsvrlkLQHTLDVKELQ 849
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 197-889 4.62e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.52  E-value: 4.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   197 RQAKERAE--RELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQqiqqmadkILELEE 274
Cdd:TIGR00618  160 AKSKEKKEllMNLFPLDQYTQLALMEFAKKKSLHGKAELLT---LRSQLLTLCTPCMPDTYHERKQ--------VLEKEL 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   275 KH-REAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKETLENMMQRHE------EEAHEKGKILSEQKAMINaMD 347
Cdd:TIGR00618  229 KHlREALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEetqeriNRARKAAPLAAHIKAVTQ-IE 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   348 SKIRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKNR 426
Cdd:TIGR00618  307 QQAQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQH 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   427 LLELETRLREVSLEHEEQKLELKRQLTElqlSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiQALTAHRD 506
Cdd:TIGR00618  376 TLTQHIHTLQQQKTTLTQKLQSLCKELD---ILQREQATIDTRTSAFRDLQGQLAHAKKQ------------QELQQRYA 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   507 EIQRKFdalrnsctvitdLEEQLNQLTEDNAELNNqnfylskqldeasgandeivqlrsevdhLRREITEREMQLTSQKQ 586
Cdd:TIGR00618  441 ELCAAA------------ITCTAQCEKLEKIHLQE----------------------------SAQSLKEREQQLQTKEQ 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   587 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVRELQRMLDTEKQSRARAD---QRITESRQ 663
Cdd:TIGR00618  481 IHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR-QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYhqlTSERKQRA 559

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 743
Cdd:TIGR00618  560 SLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQ 636

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   744 nhifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR---- 819
Cdd:TIGR00618  637 -----CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtll 706

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   820 RKEDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 889
Cdd:TIGR00618  707 RELETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 195-779 4.75e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 61.39  E-value: 4.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   195 NIRQAKERAERELEKLQNREDSsEGIRKKLVEAEERRHSLENKVKRLETMERRenrLKDDIQTKSQQIQQMADKILELEE 274
Cdd:pfam12128  215 KSRLNRQQVEHWIRDIQAIAGI-MKIRPEFTKLQQEFNTLESAELRLSHLHFG---YKSDETLIASRQEERQETSAELNQ 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   275 KHREaqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINamdskirsle 354
Cdd:pfam12128  291 LLRT-------LDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQ---------- 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   355 qrivelSEANKLAANSSLFTQRNMKAQEEMisELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:pfam12128  354 ------SELENLEERLKALTGKHQDVTAKY--NRRRSKIKEQNNR-DIAGIKDKLAKIREARDRQLAVAEDDLQALESEL 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   435 REvslEHEEQKLELKRQLTELQLSLQERESQLTALQAaraalESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ---RK 511
Cdd:pfam12128  425 RE---QLEAGKLEFNEEEYRLKSRLGELKLRLNQATA-----TPELLLQLENFDERIERAREEQEAANAEVERLQselRQ 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   512 FDALRNSCTVITDLEEQ-LNQLTEDNAELNNQNF--------YLSKqldEASGANDEIVQLRSEvDHLRREITEREMQLT 582
Cdd:pfam12128  497 ARKRRDQASEALRQASRrLEERQSALDELELQLFpqagtllhFLRK---EAPDWEQSIGKVISP-ELLHRTDLDPEVWDG 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   583 SQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRIT 659
Cdd:pfam12128  573 SVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALK 649

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   660 ESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLE 730
Cdd:pfam12128  650 NARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDA 729

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912   731 EQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 779
Cdd:pfam12128  730 QLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 168-416 1.52e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 58.62  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  168 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQnredssegirKKLVEAEERRHSLEnkvKRLETMERR 247
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE----------RRIAALARRIRALE---QELAALEAE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  248 ENRLKDDIQTKSQQIQQMADkilELEEKHREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKETLENMMQRHEE 327
Cdd:COG4942    85 LAELEKEIAELRAELEAQKE---ELAELLRALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  328 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 407
Cdd:COG4942   147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223


                  ....*....
gi 767972912  408 KLEEQLEKI 416
Cdd:COG4942   224 ELEALIARL 232
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 409-856 1.82e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 59.36  E-value: 1.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   409 LEEQLEKISHQdhsdknrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 481
Cdd:pfam15921   76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   482 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 531
Cdd:pfam15921  149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   532 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLT-------SQKQTMEALKTTCTMLEEQV 602
Cdd:pfam15921  229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITgltekasSARSQANSIQSQLEIIQEQA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   603 MDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKEHK 673
Cdd:pfam15921  309 RNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADLHK 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   674 AEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLTQG 752
Cdd:pfam15921  389 RE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAIQG 455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   753 LQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQVPL 832
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRVDL 528

                          490       500
                   ....*....|....*....|....*.
gi 767972912   833 QYNELK-LALEKEKARCAELE-EALQ 856
Cdd:pfam15921  529 KLQELQhLKNEGDHLRNVQTEcEALK 554
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 937-988 2.55e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.56  E-value: 2.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767972912  937 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20812     1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 165-864 2.91e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 58.68  E-value: 2.91e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   165 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 244
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   245 ERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 311
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   312 LADKETLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 390
Cdd:pfam10174  209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   391 QKFYletqagkleaqnrkleeqlekishQDHSDKnrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam10174  277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   471 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 543
Cdd:pfam10174  310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   544 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERQWEAWR 623
Cdd:pfam10174  383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE---EALSEKERIIERLK 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   624 svlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA--------- 690
Cdd:pfam10174  457 -----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKSleiaveqkk 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   691 ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAldradllKTER 767
Cdd:pfam10174  531 EECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-------ENEK 595

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   768 SDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELKLALEkekar 847
Cdd:pfam10174  596 NDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQLQLE----- 658

                          730
                   ....*....|....*..
gi 767972912   848 caELEEALQKTRIELRS 864
Cdd:pfam10174  659 --ELMGALEKTRQELDA 673
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 366-618 2.97e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 2.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  366 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVslehEEQK 445
Cdd:COG4942    10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL----EAEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  446 LELKRQLTELQLSLQEResqltalqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDL 525
Cdd:COG4942    86 AELEKEIAELRAELEAQ----------KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPAR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  526 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 605
Cdd:COG4942   149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225

                         250
                  ....*....|...
gi 767972912  606 EALNDELLEKERQ 618
Cdd:COG4942   226 EALIARLEAEAAA 238
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 68-812 3.09e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    68 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKATECQ 141
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   142 HKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA--------ERELEKLqNR 213
Cdd:TIGR00606  259 HNLSKIMKLDN----EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREkerelvdcQRELEKL-NK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   214 EDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH--------REAQVSAQH 285
Cdd:TIGR00606  334 ERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHtlvierqeDEAKTAAQL 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   286 LEvHLKQKEQHYEEKIKVLDNQIKkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 365
Cdd:TIGR00606  414 CA-DLQSKERLKQEQADEIRDEKK---GLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSK 489

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   366 LAANSSLFTqrnmkaqeemiseLRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLL------ELETRLREVSL 439
Cdd:TIGR00606  490 AEKNSLTET-------------LKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmDKDEQIRKIKS 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   440 EHEEqklELKRQLTELQLSLQeRESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 519
Cdd:TIGR00606  557 RHSD---ELTSLLGYFPNKKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVC 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   520 TViTDLEEQLNQLTEDNAELNNQNFYLSKqldeASGANDEIVQLRSEVDHLRREITEREMQltSQKQTMEALKTTCTMLE 599
Cdd:TIGR00606  633 GS-QDEESDLERLKEEIEKSSKQRAMLAG----ATAVYSQFITQLTDENQSCCPVCQRVFQ--TEAELQEFISDLQSKLR 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   600 EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAE 675
Cdd:TIGR00606  706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAK 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   676 IL--------ALQQALKEQKLKAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQ 742
Cdd:TIGR00606  786 VCltdvtimeRFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSK 865

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   743 KNHIFRLTQGLQEALDRADLLKTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 812
Cdd:TIGR00606  866 TNELKSEKLQIGTNLQRRQQFEEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-741 3.43e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 58.65  E-value: 3.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL---KRSLEQARMEVSQEddkalqlLHDIRE 78
Cdd:pfam01576  101 MQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLskeRKLLEERISEFTSN-------LAEEEE 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    79 QSRKLQEIKEQeYQAQVEEMRLMMNQLE---EDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQG 151
Cdd:pfam01576  174 KAKSLSKLKNK-HEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQiaelQAQIAELRAQLAKKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIR-KKLVEAEER 230
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRsKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   231 RHSLENKVKRLETmerrenRLKDDIQTKSQQIQQMADKI---------LELEEKHREAQVSAQHLEVH-LKQKEQHYEEK 300
Cdd:pfam01576  333 KKALEEETRSHEA------QLQEMRQKHTQALEELTEQLeqakrnkanLEKAKQALESENAELQAELRtLQQAKQDSEHK 406

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   301 IKVLDNQikkdladketLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAanSSLFTQrnMKA 380
Cdd:pfam01576  407 RKKLEGQ----------LQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV--SSLESQ--LQD 472

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdknrlleletrlrevslEHEEQKLELKRQLTELQLSLQ 460
Cdd:pfam01576  473 TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLE-------------------------EEEEAKRNVERQLSTLQAQLS 527

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   461 ERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA---------------------------LTAHRDEIQRKFD 513
Cdd:pfam01576  528 DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAydklektknrlqqelddllvdldhqrqLVSNLEKKQKKFD 607

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   514 -ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEI----VQLRSEVDHL-------RREITEREMQL 581
Cdd:pfam01576  608 qMLAEEKAISARYAEERDRAEAEAREKETRALSLARALEEALEAKEELertnKQLRAEMEDLvsskddvGKNVHELERSK 687

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   582 TSQKQTMEALKTTCTMLEEQvmdLEALNDELLEKERQWEAW----------RSVLGDEKS-QFECRVRELQRMLDTEKQS 650
Cdd:pfam01576  688 RALEQQVEEMKTQLEELEDE---LQATEDAKLRLEVNMQALkaqferdlqaRDEQGEEKRrQLVKQVRELEAELEDERKQ 764

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   651 RARAdqriTESRQVVELAVKEHKAEILALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQ 726
Cdd:pfam01576  765 RAQA----VAAKKKLELDLKELEAQIDAANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKN 837

                          810
                   ....*....|....*
gi 767972912   727 RlleEQAKLQQQMDL 741
Cdd:pfam01576  838 L---EAELLQLQEDL 849
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 15-294 4.38e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.21  E-value: 4.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    15 EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLhdirEQSRKlQEIKEQEYQAQ 94
Cdd:pfam17380  340 ERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQEL----EAARK-VKILEEERQRK 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    95 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLaaEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQE 174
Cdd:pfam17380  415 IQQQKVEMEQIRAEQEEARQREVRRLEEERAREM--ERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQ 492

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   175 LQEKLEKAVKASTEAteLLQNIRQAKeRAERELEKLQNredssegirkKLVEAEERRHSLENKVKRLETMERREnrlkdd 254
Cdd:pfam17380  493 RRKILEKELEERKQA--MIEEERKRK-LLEKEMEERQK----------AIYEEERRREAEEERRKQQEMEERRR------ 553

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 767972912   255 IQtksQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKE 294
Cdd:pfam17380  554 IQ---EQMRKATEERSRLEAMEREREMMRQIVESEKARAE 590
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
297-868 4.39e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.15  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  297 YEEKIKVLDNQIKKDLADKETLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 376
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  377 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRLLELETRLREV-SLEHEEQK-LELKRQLTE 454
Cdd:PRK03918  232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  455 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 534
Cdd:PRK03918  305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  535 DNAELNNQNF-YLSKQLDEASGANDEIvqlRSEVDHLRREITEREMQLTSQKQTMEALKT------TCTMLEEQVMDLEA 607
Cdd:PRK03918  377 LKKRLTGLTPeKLEKELEELEKAKEEI---EEEISKITARIGELKKEIKELKKAIEELKKakgkcpVCGRELTEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  608 LNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEilalqqALKEQK 687
Cdd:PRK03918  454 LEEYTAELKRI-EKELKEIEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLE------ELEKKA 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  688 LKAESLSDKLNDLEKKhamlemnARSLQQKLETERELKQRLLEEQAKLQQqmdlqknhifrltqglqealdradlLKTER 767
Cdd:PRK03918  525 EEYEKLKEKLIKLKGE-------IKSLKKELEKLEELKKKLAELEKKLDE-------------------------LEEEL 572

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  768 SDLEYQLENIQVLYSHEkvkMEGTISQQTKLID-FLQAKmdqPAKKKKglfsRRKEDpalptqvplqynelklALEKEKA 846
Cdd:PRK03918  573 AELLKELEELGFESVEE---LEERLKELEPFYNeYLELK---DAEKEL----EREEK----------------ELKKLEE 626

                         570       580
                  ....*....|....*....|..
gi 767972912  847 RCAELEEALQKTRIELRSAREE 868
Cdd:PRK03918  627 ELDKAFEELAETEKRLEELRKE 648
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1020-1139 6.95e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 52.18  E-value: 6.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1099
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767972912  1100 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 253-483 7.79e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 7.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  253 DDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK 332
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  333 GKILSEQKAMinamdskirsLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 412
Cdd:COG4942    96 RAELEAQKEE----------LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912  413 LEKISHQdhsdKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 483
Cdd:COG4942   166 RAELEAE----RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 290-484 8.89e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 8.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  290 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS---EANKL 366
Cdd:COG4942    25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaelEAQKE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  367 AANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKIshqdHSDKNRLLELETRLREVSLEHEEQK 445
Cdd:COG4942   105 ELAELLRALYRLGRQPPLALLLSPEDFLdAVRRLQYLKYLAPARREQAEEL----RADLAELAALRAELEAERAELEALL 180

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767972912  446 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 484
Cdd:COG4942   181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2-359 9.82e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.97  E-value: 9.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATY----------ITECSSLKRSLEQARMEVSQ---EDDK 68
Cdd:PRK02224  354 LEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELrerfgdapvdLGNAEDFLEELREERDELREreaELEA 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   69 ALQLLHDIREQSRKL----------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAEEFKRKAT 138
Cdd:PRK02224  434 TLRTARERVEEAEALleagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AEDLVEAED 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  139 ECQHKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLE----KAVKASTEATELLQNIRQAKERA---ERELEKLQ 211
Cdd:PRK02224  510 RIERLEERREDLEE----LIAERRETIEEKRERAEELRERAAeleaEAEEKREAAAEAEEEAEEAREEVaelNSKLAELK 585

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  212 NREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILE--LEEKHREAQVSAQHLEvH 289
Cdd:PRK02224  586 ERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEarIEEAREDKERAEEYLE-Q 664

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912  290 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE--EEAHEKGKILSEQKAMINAMDSKIRS-LEQRIVE 359
Cdd:PRK02224  665 VEEKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELESMYGDLRAeLRQRNVE 737
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
506-785 1.03e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 57.23  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  506 DEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQK 585
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREQIELLEP-----------IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL--LE 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  586 QTMEALKTTCTMLEEQVMDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQV 664
Cdd:COG4913   295 AELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AA 370

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  665 VELAVKEHKAEILALQQALKEQKLKAESLSDKlndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKN 744
Cdd:COG4913   371 LGLPLPASAEEFAALRAEAAALLEALEEELEA-----------------LEEALAEAEAALRDLRRELRELEAEIASLER 433

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 767972912  745 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEK 785
Cdd:COG4913   434 RKSNIPARLLALRDAlAEALGLDEAELPFVGELIEVRPEEER 475
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
508-740 1.03e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.95  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  508 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:COG3206   166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  582 TSQKQTMEALKTTCTMLEEQVMdLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITES 661
Cdd:COG3206   243 AALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQQEAQRILAS 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  662 RQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE--EQAKLQQQM 739
Cdd:COG3206   318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrlEEARLAEAL 383


                  .
gi 767972912  740 D 740
Cdd:COG3206   384 T 384
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 659-870 1.13e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.93  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  659 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 738
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  739 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 800
Cdd:COG4942    99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  801 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 870
Cdd:COG4942   175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
376-771 1.28e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.31  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  376 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSlEHEEQKLELKRQLT 453
Cdd:COG4717    71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  454 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 533
Cdd:COG4717   150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  534 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQTM 588
Cdd:COG4717   227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  589 EALKTTCTMLEEQV---------MDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 653
Cdd:COG4717   307 LQALPALEELEEEEleellaalgLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  654 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 733
Cdd:COG4717   387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 767972912  734 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 771
Cdd:COG4717   457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 402-859 1.38e-07

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 55.84  E-value: 1.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   402 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALESQLR 481
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGK----LRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   482 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 561
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   562 QLRSEVDHLRREITEREMQLTSQKQTMEALkttctmLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQ 641
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQAL------SEEQAAELAELTRRLAELETQLDATRA-----------RLRALE 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   642 RMLDTEKQSRARADQRItesrqvvELAVKEHKAEILALqqalkeqKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETE 721
Cdd:pfam19220  216 GQLAAEQAERERAEAQL-------EEAVEAHRAERASL-------RMKLEALTARAAATEQ---LLAEARNQLRDRDEAI 278

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   722 RELKQRLLE---EQAKLQQQMDLQKNHIFRLTQGLQEaLDRADLLKTERSDLEyqlenIQVLYSHEKvkmegTISQQTKL 798
Cdd:pfam19220  279 RAAERRLKEasiERDTLERRLAGLEADLERRTQQFQE-MQRARAELEERAEML-----TKALAAKDA-----ALERAEER 347

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912   799 IDFLQAKMDQPAKKkkglfsRRKEDPALPTQVplqyNELKLALEKEKARCAELEEALQKTR 859
Cdd:pfam19220  348 IASLSDRIAELTKR------FEVERAALEQAN----RRLKEELQRERAERALAQGALEIAR 398
PRK12704 PRK12704
phosphodiesterase; Provisional
 171-334 1.46e-07

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 55.94  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  171 KIQELQEKLEKAVK-ASTEATELLQN-IRQAKERAERELEKLqnrEDSSEGIRKKLVEAEERRHSLENKV-KRLETMERR 247
Cdd:PRK12704   32 KIKEAEEEAKRILEeAKKEAEAIKKEaLLEAKEEIHKLRNEF---EKELRERRNELQKLEKRLLQKEENLdRKLELLEKR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  248 ENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLAdketleNMMQRHE 326
Cdd:PRK12704  109 EEELEKKEKELEQKQQELEKKEEELEELIEEQL---QELERISGlTAEEAKEILLEKVEEEARHEAA------VLIKEIE 179


                  ....*...
gi 767972912  327 EEAHEKGK 334
Cdd:PRK12704  180 EEAKEEAD 187
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 307-865 2.08e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 55.90  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   307 QIKKDLADKEtLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 384
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   385 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 461
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   462 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 536
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   537 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVMDLEALNDELL 613
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQQREIVLKEENSSLT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   614 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALKEQKLKA 690
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSPQLLERI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   691 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDRADLLKT 765
Cdd:pfam05557  383 EEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLRE 462

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   766 ERSDLEYQLE--NIQVLYSHEKVKM-------EGTISQQTK-LIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL--- 832
Cdd:pfam05557  463 QKNELEMELErrCLQGDYDPKKTKVlhlsmnpAAEAYQQRKnQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTmnf 542

                          570       580       590
                   ....*....|....*....|....*....|....
gi 767972912   833 -QYNELKLALEKEKARCAELEEALQKTRIELRSA 865
Cdd:pfam05557  543 kEVLDLRKELESAELKNQRLKEVFQAKIQEFRDV 576
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 433-759 2.17e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 56.11  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  433 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 512
Cdd:COG3096   282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  513 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 592
Cdd:COG3096   354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALE 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  593 TTCTMLEEQVMDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA--RADQRITE 660
Cdd:COG3096   424 KARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAwqTARELLRR 503

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  661 SRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETERELKQRLLEE 731
Cdd:COG3096   504 YRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVEQ 579

                         330       340       350
                  ....*....|....*....|....*....|....
gi 767972912  732 QAKLQQQMDLQKNHIFRLTQ------GLQEALDR 759
Cdd:COG3096   580 RSELRQQLEQLRARIKELAArapawlAAQDALER 613
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
8-577 2.33e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.08  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    8 RLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATyitecssLKRSLEQARMEVSQEDDKAL-QLLHDIREQSRKLQEI 86
Cdd:COG4913   285 FAQRRLELLEAELEELRAELARLEAELERLEARLDA-------LREELDELEAQIRGNGGDRLeQLEREIERLERELEER 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   87 KE--QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEK- 163
Cdd:COG4913   358 ERrrARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSn 437

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  164 INAEQqlkiQELQEKLEKAVKASTE----ATELLQnIRQAKER----AEREL-----------------------EKLQN 212
Cdd:COG4913   438 IPARL----LALRDALAEALGLDEAelpfVGELIE-VRPEEERwrgaIERVLggfaltllvppehyaaalrwvnrLHLRG 512

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  213 REDsSEGIRKKLVEAEERR---HSLENKVKRLET---------MERRENRLK-DDIQ---------TKSQQIQQMAdkil 270
Cdd:COG4913   513 RLV-YERVRTGLPDPERPRldpDSLAGKLDFKPHpfrawleaeLGRRFDYVCvDSPEelrrhpraiTRAGQVKGNG---- 587

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  271 ELEEKHREAQVSAQHLevhL----KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM 346
Cdd:COG4913   588 TRHEKDDRRRIRSRYV---LgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVA 664

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  347 --DSKIRSLEQRIVELSEAN-KLAAnsslfTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsd 423
Cdd:COG4913   665 saEREIAELEAELERLDASSdDLAA-----LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD--------- 730

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  424 knrllELETRLREV-SLEHEEQKLELKRQLTELQLSLQERESQlTALQAARAALESQLRQAKteleettaeaeeeiQALT 502
Cdd:COG4913   731 -----ELQDRLEAAeDLARLELRALLEERFAAALGDAVERELR-ENLEERIDALRARLNRAE--------------EELE 790

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  503 AHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER 577
Cdd:COG4913   791 RAMRAFNREWPAETADLDAdlesLPEYLALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKER 865
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 553-815 2.63e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  553 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTtctmleeqvmDLEALNDELLEKERQweawrsvlgdeksq 632
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK----------QLAALERRIAALARR-------------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  633 fecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 712
Cdd:COG4942    71 ----IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  713 SLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTI 792
Cdd:COG4942   147 ARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222

                         250       260
                  ....*....|....*....|...
gi 767972912  793 SQQTKLIDFLQAKMDQPAKKKKG 815
Cdd:COG4942   223 EELEALIARLEAEAAAAAERTPA 245
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1020-1139 2.67e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 2.67e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   1020 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1099
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 767972912   1100 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1139
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 120-739 2.83e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 55.61  E-value: 2.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   120 ESELRES---RLAAEEFKRKATECQ-HKLLKAKDQGKPEVGEyaKLEKINAEQQLKIQELQEKL---EKAVKASTEATEL 192
Cdd:pfam12128  249 EFNTLESaelRLSHLHFGYKSDETLiASRQEERQETSAELNQ--LLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEA 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   193 LQNirQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLE-TMERRENRLKDDIQTKSQQIQQMADKILE 271
Cdd:pfam12128  327 LED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIRE 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   272 LEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 350
Cdd:pfam12128  405 ARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAAN 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   351 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKlEEQLEKISHQDHSDKNRLL-- 428
Cdd:pfam12128  485 AEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrt 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   429 ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEE 496
Cdd:pfam12128  564 DLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETF 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   497 EIQALTAHRDEIQRKFDALRNSCTVITD--------LEEQLNQL-TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV 567
Cdd:pfam12128  644 ARTALKNARLDLRRLFDEKQSEKDKKNKalaerkdsANERLNSLeAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV 723

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   568 dhlrreITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEKerqweawRSVLGDEKSQFECRVRELQRMLDTE 647
Cdd:pfam12128  724 ------EGALDAQLALLKAAIAARRSG---AKAELKALETWYKRDLAS-------LGVDPDVIAKLKREIRTLERKIERI 787

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   648 KQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----E 723
Cdd:pfam12128  788 AVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseK 853

                          650
                   ....*....|....*.
gi 767972912   724 LKQRLLEEQAKLQQQM 739
Cdd:pfam12128  854 QQVRLSENLRGLRCEM 869
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1-276 3.30e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.46  E-value: 3.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     1 MMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQED-DKALQLLHDIREQ 79
Cdd:TIGR02169  727 QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKLEEE 806

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    80 SRKLQEI------KEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDqgkp 153
Cdd:TIGR02169  807 VSRIEARlreieqKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLES---- 882

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   154 evgEYAKLEKINAEQQLKIQELQEKLEKAvKASTEATELLQNIRQAKeraereLEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:TIGR02169  883 ---RLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSELKAK------LEALEEELSEIEDPKGEDEEIPEEELS 952

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 767972912   234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH 276
Cdd:TIGR02169  953 LEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKR 995
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 157-319 3.58e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 53.00  E-value: 3.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEgirKKLVEAeerrhsleN 236
Cdd:COG1579    18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  237 KVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 316
Cdd:COG1579    87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                  ...
gi 767972912  317 TLE 319
Cdd:COG1579   167 ELA 169
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
500-869 3.75e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  500 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 579
Cdd:PRK02224  188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  580 QLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS--------- 650
Cdd:PRK02224  266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAaqahneeae 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  651 --RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL 728
Cdd:PRK02224  346 slREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDEL 424

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  729 LEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshEKVKMEGTIS 793
Cdd:PRK02224  425 REREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----EVEEVEERLE 499

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  794 QQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEA 869
Cdd:PRK02224  500 RAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 443-705 4.11e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 4.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  443 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 522
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  523 tDLEEQLNQLTEDNAELNNQnfylskqldeasgandeIVQLRSEVDHLRREITE--REMQLTSQKQTMEALKTTCTMLE- 599
Cdd:COG4942    73 -ALEQELAALEAELAELEKE-----------------IAELRAELEAQKEELAEllRALYRLGRQPPLALLLSPEDFLDa 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  600 -EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelaVKEHKAEILA 678
Cdd:COG4942   135 vRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL----LARLEKELAE 210

                         250       260
                  ....*....|....*....|....*..
gi 767972912  679 LQQALKEQKLKAESLSDKLNDLEKKHA 705
Cdd:COG4942   211 LAAELAELQQEAEELEALIARLEAEAA 237
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
8-328 4.15e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.77  E-value: 4.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    8 RLHRRVSEVEAVLSQKEV---ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-LLHDIREQSRKL 83
Cdd:COG4717   129 PLYQELEALEAELAELPErleELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQdLAEELEELQQRL 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   84 QEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAA------------------------------- 130
Cdd:COG4717   209 AELEEELEEAQEELEELEeeLEQLENELEAAALEERLKEARLLLLIAAAllallglggsllsliltiagvlflvlgllal 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  131 --EEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELE 208
Cdd:COG4717   289 lfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEEL 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  209 KLQNRE-------DSSEGIRKKLvEAEERRHSLENKVKRLETMERREN-------------RLKDDIQTKSQQIQQMADK 268
Cdd:COG4717   369 EQEIAAllaeagvEDEEELRAAL-EQAEEYQELKEELEELEEQLEELLgeleellealdeeELEEELEELEEELEELEEE 447

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  269 ILELEEKHREAQVSAQHLE-----VHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:COG4717   448 LEELREELAELEAELEQLEedgelAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 164-584 4.33e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 54.75  E-value: 4.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   164 INAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRH----------- 232
Cdd:pfam05557   12 SQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALReqaelnrlkkk 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   233 SLENKVKRLETMERRENRLKDDIQTKSQQI----QQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDNQi 308
Cdd:pfam05557   84 YLEALNKKLNEKESQLADAREVISCLKNELselrRQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLRQNLEKQ- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   309 KKDLADKE----TLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ--------- 375
Cdd:pfam05557  162 QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEevedlkrkl 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   376 -RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQD--HSDKNRLLELETR-LREVSLEHE 442
Cdd:pfam05557  238 eREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREivLKEENSSLTSSARqLEKARRELE 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   443 EQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQALTAHRD 506
Cdd:pfam05557  318 QELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQKMQAHNE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   507 EIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREITEREMQLT 582
Cdd:pfam05557  398 EMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKNELEMELE 472


                   ..
gi 767972912   583 SQ 584
Cdd:pfam05557  473 RR 474
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 170-319 5.09e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.62  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  170 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLET--MERR 247
Cdd:COG1579    10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  248 ENR----LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 319
Cdd:COG1579    87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 598-891 5.10e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 5.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   598 LEEQVMDLEALNDELLEKERQWEawrsvlgdeksqfecrvrELQRmldtekqsRARADQRITESRQvvelAVKEHKAEIL 677
Cdd:TIGR02168  181 LERTRENLDRLEDILNELERQLK------------------SLER--------QAEKAERYKELKA----ELRELELALL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   678 ALQqaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL 757
Cdd:TIGR02168  231 VLR--LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILR 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   758 DRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQY 834
Cdd:TIGR02168  309 ERLANLERQLEELEAQLEELEsklDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV 388

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   835 NELKLALEKEKARCAELEEalQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIA 891
Cdd:TIGR02168  389 AQLELQIASLNNEIERLEA--RLERLEDRRERLQQEIEELLKKLEEAELKELQAELE 443
mukB PRK04863
chromosome partition protein MukB;
197-578 7.30e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 54.19  E-value: 7.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  197 RQAKERAERELEKLQNREDSSeGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------QQIQ 263
Cdd:PRK04863  276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  264 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKETLENMMQRHEEEAHEKGKIL 336
Cdd:PRK04863  352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  337 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 411
Cdd:PRK04863  424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  412 QLEKISHQDhsdkNRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 488
Cdd:PRK04863  504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  489 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 568
Cdd:PRK04863  579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658

                         410
                  ....*....|
gi 767972912  569 HLRREITERE 578
Cdd:PRK04863  659 EEIERLSQPG 668
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 30-822 9.45e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 54.29  E-value: 9.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    30 SETQRSLLE--QDLAT------YITECSSLKRSLEQAR----------------------MEVSQEDDKALQLLHDIREQ 79
Cdd:TIGR01612  900 NEINKSIEEeyQNINTlkkvdeYIKICENTKESIEKFHnkqnilkeilnknidtikesnlIEKSYKDKFDNTLIDKINEL 979

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    80 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLvSARRRSDLYEsELRESRLAAEEFKRKATECQhkllkaKDQGKPEVGEYA 159
Cdd:TIGR01612  980 DKAFKDASLNDYEAKNNELIKYFNDLKANL-GKNKENMLYH-QFDEKEKATNDIEQKIEDAN------KNIPNIEIAIHT 1051

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   160 KLEKINAEQQLKIQELQEKLEKAV--KASTEATellqNIRQAKERAereleKLQNREDSSEgirkklveaeerrhslENK 237
Cdd:TIGR01612 1052 SIYNIIDEIEKEIGKNIELLNKEIleEAEINIT----NFNEIKEKL-----KHYNFDDFGK----------------EEN 1106

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   238 VKRLETMerreNRLKDDIQTKSQQIQQmadKILELEEkhreaqvsaqhlevhLKQKEQHYEEKIKVLDNQIkKDLADK-- 315
Cdd:TIGR01612 1107 IKYADEI----NKIKDDIKNLDQKIDH---HIKALEE---------------IKKKSENYIDEIKAQINDL-EDVADKai 1163

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   316 -----ETLENMMQRHEEEAHEKGKILSEQKAMINAMdSKIR----SLEQ-RIVELSEANKLAA----------NSSLFTQ 375
Cdd:TIGR01612 1164 snddpEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI-AEIEkdktSLEEvKGINLSYGKNLGKlflekideekKKSEHMI 1242

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   376 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEeqLEKISHQDHSDKNrlleletrlrEVSLEHEEQKLELKrqltEL 455
Cdd:TIGR01612 1243 KAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEME--TFNISHDDDKDHH----------IISKKHDENISDIR----EK 1306

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   456 QLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiqaLTAHRDEIQRKFDALR--NSCTVITDLEEQLNQLT 533
Cdd:TIGR01612 1307 SLKIIEDFSEESDINDIKKELQKNLLDAQKHNSD-----------INLYLNEIANIYNILKlnKIKKIIDEVKEYTKEIE 1375

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   534 EDNAELNNQ---NFYLSKQLDEASGANDEIVQLRS-----EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMdL 605
Cdd:TIGR01612 1376 ENNKNIKDEldkSEKLIKKIKDDINLEECKSKIEStlddkDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVL-L 1454

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   606 EALNDELLEKERQWeawrsVLGDEK----SQFECRVRELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQ 681
Cdd:TIGR01612 1455 LFKNIEMADNKSQH-----ILKIKKdnatNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLN 1528

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   682 ALKEQKLK---AESLSDK---LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQ 751
Cdd:TIGR01612 1529 KYSALAIKnkfAKTKKDSeiiIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LE 1603

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912   752 GLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGT-ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKE 822
Cdd:TIGR01612 1604 NFENKFLKISDIKKKINDCLKETESIEKKISSFSIDSQDTeLKENGDNLNSLQEFLESLKDQKKNIEDKKKE 1675
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 313-538 1.02e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  313 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQK 392
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA-------LEQELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  393 FYLETQAGKLEAQNRKLEEQLEKISHQDH-------SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ 465
Cdd:COG4942    93 AELRAELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912  466 LTALQAARAALESQlrqaKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 538
Cdd:COG4942   173 RAELEALLAELEEE----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 522-744 1.08e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.84  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  522 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 601
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  602 vmdLEALNDELleKERQWEAWRS---------VLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVKEH 672
Cdd:COG4942    99 ---LEAQKEEL--AELLRALYRLgrqpplallLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRAEL 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912  673 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 744
Cdd:COG4942   170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 324-752 1.27e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 53.42  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  324 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 398
Cdd:COG3096   275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  399 AGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 478
Cdd:COG3096   353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  479 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 555
Cdd:COG3096   424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  556 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEkerqWEAWRSV 625
Cdd:COG3096   493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE----LEAQLEE 568

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  626 LGDEKSQFECRVRELQRmldTEKQSRARADqritesrqvvELAVKEhkAEILALQQALkeqklkaESLSDKLND-LEKKH 704
Cdd:COG3096   569 LEEQAAEAVEQRSELRQ---QLEQLRARIK----------ELAARA--PAWLAAQDAL-------ERLREQSGEaLADSQ 626

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  705 AMleMNARslQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 752
Cdd:COG3096   627 EV--TAAM--QQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 934-989 1.91e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.91e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   934 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 499-719 1.97e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  499 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREI 574
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALarriRALEQELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  575 TEREMQLTSQKQTM-EALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRar 653
Cdd:COG4942    93 AELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAALR-- 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  654 adQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 719
Cdd:COG4942   167 --AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
249-778 2.32e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 52.35  E-value: 2.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  249 NRLKDDiqtKSQQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:PRK02224  179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  329 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 408
Cdd:PRK02224  250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  409 LEEQLEKISHQDHSDKNRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 488
Cdd:PRK02224  295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  489 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 566
Cdd:PRK02224  367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  567 VDHLRreitEREMQLTSQKQTmealkttctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 646
Cdd:PRK02224  421 RDELR----EREAELEATLRT----------ARERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELED 486

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  647 EKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 722
Cdd:PRK02224  487 LEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAE 564

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  723 ELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 778
Cdd:PRK02224  565 EEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 650-927 2.40e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  650 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 727
Cdd:COG3883    10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  728 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 804
Cdd:COG3883    86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  805 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 884
Cdd:COG3883   141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 767972912  885 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 927
Cdd:COG3883   221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 375-590 2.40e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  375 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE 454
Cdd:COG4942    33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  455 LQLSLQERE-----SQLTALQAARAA--LESQLRQAKTELEETTaeaeEEIQALTAHRDEIQRKFDALRnscTVITDLEE 527
Cdd:COG4942   113 LYRLGRQPPlalllSPEDFLDAVRRLqyLKYLAPARREQAEELR----ADLAELAALRAELEAERAELE---ALLAELEE 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912  528 QLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 590
Cdd:COG4942   186 ERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
46 PHA02562
endonuclease subunit; Provisional
 360-612 3.44e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 51.55  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  360 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKNrllELETRLREVSL 439
Cdd:PHA02562  165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  440 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE------------ETTAEAEEEIQALTAHRDE 507
Cdd:PHA02562  231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKE 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  508 IQRKFDALRNSctvITDLEEQLNQ-------LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 580
Cdd:PHA02562  311 LQHSLEKLDTA---IDELEEIMDEfneqskkLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDE 387

                         250       260       270
                  ....*....|....*....|....*....|..
gi 767972912  581 LTsqkqtmeALKTTCTMLEEQVMDLEALNDEL 612
Cdd:PHA02562  388 LD-------KIVKTKSELVKEKYHRGIVTDLL 412
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-565 4.07e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 4.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYIT---ECSSLKRSLEQARMEVSQEDDKALQLLHDIRE 78
Cdd:pfam01576  515 VERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQqleEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQ 594

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    79 QSRKLqEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYES-------ELRESRLAAEEFKRkatecQHKLLKA---- 147
Cdd:pfam01576  595 LVSNL-EKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETralslarALEEALEAKEELER-----TNKQLRAemed 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   148 ----KDQGKPEVGEYAKlEKINAEQQLKIQELQ-EKLEKAVKASTEATELLQ-NIRQAKERAERELeklQNREDssegir 221
Cdd:pfam01576  669 lvssKDDVGKNVHELER-SKRALEQQVEEMKTQlEELEDELQATEDAKLRLEvNMQALKAQFERDL---QARDE------ 738

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   222 kklvEAEERRHSLENKVKRLETMerrenrLKDDIQTKSQQIQqmADKILELEEKHREAQVSAQHlevhlkqkeQHYEEKI 301
Cdd:pfam01576  739 ----QGEEKRRQLVKQVRELEAE------LEDERKQRAQAVA--AKKKLELDLKELEAQIDAAN---------KGREEAV 797

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   302 KvldnQIKKDLADKETLenmmQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNMK 379
Cdd:pfam01576  798 K----QLKKLQAQMKDL----QRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQE 862

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   380 aQEEMISELRQQ---KFYLETQAGKLEAQNRKLEEQLEKISHQDH--SDKNRLLELETRLREVSLEHEE---QKLE---- 447
Cdd:pfam01576  863 -RDELADEIASGasgKSALQDEKRRLEARIAQLEEELEEEQSNTEllNDRLRKSTLQVEQLTTELAAERstsQKSEsarq 941

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   448 -LKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQR 510
Cdd:pfam01576  942 qLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQY 1021

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912   511 KfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 565
Cdd:pfam01576 1022 K-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1496-1585 4.09e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1496 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1557
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767972912 1558 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1585
Cdd:PTZ00449  605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 77-777 4.92e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 51.36  E-value: 4.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    77 REQSRKLQEIKEQEYQAQVE--EMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 154
Cdd:pfam10174   49 KEEAARISVLKEQYRVTQEEnqHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQ 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   155 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNirqakeraeRELEKLQNREDSSEGIRkkLVEAEERRHSL 234
Cdd:pfam10174  129 AKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQS---------KGLPKKSGEEDWERTRR--IAEAEMQLGHL 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   235 EN--------KVKRLETMERRENRLKDDIQTKS-QQIQQMAD-KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVL 304
Cdd:pfam10174  198 EVlldqkekeNIHLREELHRRNQLQPDPAKTKAlQTVIEMKDtKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQM 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   305 D-------------NQIKKDLADKETLENMMQRHEEEAHEKGkilSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANS 370
Cdd:pfam10174  278 EvykshskfmknkiDQLKQELSKKESELLALQTKLETLTNQN---SDCKQHIEVLKESLTAKEQRAAILqTEVDALRLRL 354

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   371 SLfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEHEEQKLELKR 450
Cdd:pfam10174  355 EE-KESFLNKKTKQLQDLTEEK---STLAGEIRDLKDMLDVKERKI--------NVLQKKIENLQEQLRDKDKQLAGLKE 422

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   451 QLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRNSCTVITDLEEQL 529
Cdd:pfam10174  423 RVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELESLKKENKDLKEKV 484

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   530 NQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltsQKQTMEALKTTCTMLEEQVMDLEA-L 608
Cdd:pfam10174  485 SAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV---------EQKKEECSKLENQLKKAHNAEEAVrT 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   609 NDELLEKERQWEAWRSVLGDE--KSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvelavkehkAEILALQQaLKE 685
Cdd:pfam10174  553 NPEINDRIRLLEQEVARYKEEsgKAQAEVeRLLGILREVENEKNDK---DKKIAE-------------LESLTLRQ-MKE 615

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   686 QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNHIFRLTQGLQEaldRADLL 763
Cdd:pfam10174  616 QNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKARLSSTQQSLAE---KDGHL 692

                          730
                   ....*....|....
gi 767972912   764 KTERSDLEYQLENI 777
Cdd:pfam10174  693 TNLRAERRKQLEEI 706
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 261-741 5.91e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.34  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  261 QIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKETLEnmmqrheeEAHEKGKILSEQK 340
Cdd:PRK10246  434 QIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQEARIKDLEAQR 497

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  341 AMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrkLEEQLekisH 418
Cdd:PRK10246  498 AQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA----LTKQL----Q 561

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  419 QDHSDKNRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQLTALQAARAA 475
Cdd:PRK10246  562 RDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQ 641

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  476 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELnnqnfylsKQLDEASg 555
Cdd:PRK10246  642 RQQQLLTALAGYALTLPQEDEEASWLATRQQEAQS----WQQRQNELTALQNRIQQLTPLLETL--------PQSDDLP- 708

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  556 ANDEIVQLrsevDHLrREITEREMQLTSQKQTMEALkttctmleeqvmdlealndELLEKERQWEA---WRSVLgdEKSQ 632
Cdd:PRK10246  709 HSEETVAL----DNW-RQVHEQCLSLHSQLQTLQQQ-------------------DVLEAQRLQKAqaqFDTAL--QASV 762

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  633 FECRVRELQRMLDTEkqsrarADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 712
Cdd:PRK10246  763 FDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQ 836

                         490       500
                  ....*....|....*....|....*....
gi 767972912  713 SLQQKLETERELKQRLLEEQAKLQQQMDL 741
Cdd:PRK10246  837 QLRENTTRQGEIRQQLKQDADNRQQQQAL 865
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
159-514 7.02e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 50.29  E-value: 7.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  159 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegirkklvEAEERRHSLENKV 238
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  239 KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKETL 318
Cdd:COG4372    94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  319 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 398
Cdd:COG4372   170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  399 AGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:COG4372   250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 767972912  479 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 514
Cdd:COG4372   330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 3-283 7.78e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.84  E-value: 7.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLA-TYITECSSLKRSLEQARMEVS---QEDDKALQLLHDIRE 78
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLShSRIPEIQAELSKLEEEVSRIEarlREIEQKLNRLTLEKE 829

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    79 QSRKL-QEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEV 155
Cdd:TIGR02169  830 YLEKEiQELQEQriDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELE 909

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   156 GEYAKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRH 232
Cdd:TIGR02169  910 AQIEKKRKRLSELKAKLEALEEELseiEDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLD 989

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767972912   233 SLENKVKRLETmERREnrlkddiqtksqqiqqMADKILELEEKHREAQVSA 283
Cdd:TIGR02169  990 ELKEKRAKLEE-ERKA----------------ILERIEEYEKKKREVFMEA 1023
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 134-329 7.93e-06

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 48.87  E-value: 7.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   134 KRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNR 213
Cdd:pfam00261    7 KEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESERGRKVLENR 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   214 ----EDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVH 289
Cdd:pfam00261   87 alkdEEKMEILEAQLKEAKEIAEEAD---RKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEAS 163

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 767972912   290 LK---QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 329
Cdd:pfam00261  164 EEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
71-273 7.99e-06

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 50.33  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   71 QLLHDIREQSRklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL---RESRLAAEEFKRKATECQHKLLKA 147
Cdd:COG4487    18 SLYADIVKQRR-------AEFEKELAERLADAAKREAALELAEAKAKAQLQEQvaeKDAEIAELRARLEAEERKKALAVA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  148 KDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATEllqnirqAKERAERELEK--LQNREDSSEGIRKKLV 225
Cdd:COG4487    91 EEKEK----ELAALQEALAEKDAKLAELQAKELELLKKERELED-------AKREAELTVEKerDEELDELKEKLKKEEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 767972912  226 EAEERRHSLEN--KVKRLETMERRENRLKDDIQtksQQIQQMADKILELE 273
Cdd:COG4487   160 EKQLAEKSLKVaeYEKQLKDMQEQIEELKRKKE---QGSTQLQGEVLELE 206
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 566-872 8.17e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.99  E-value: 8.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   566 EVDHLRREITEREmQLTSQKQTMEALKTTctMLEEQVMDLEALNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLD 645
Cdd:pfam12128  229 DIQAIAGIMKIRP-EFTKLQQEFNTLESA--ELRLSHLHFGYKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRD 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   646 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL- 724
Cdd:pfam12128  305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKi 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   725 KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQA 804
Cdd:pfam12128  385 KEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912   805 kmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQKTRIELRSAREEAAHR 872
Cdd:pfam12128  459 ------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQSELRQARKRRDQASEA 507
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 14-484 8.89e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.61  E-value: 8.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    14 SEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSL--------------EQARMEVSQEDDKALQLLHD---- 75
Cdd:pfam12128  322 SELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLkaltgkhqdvtakyNRRRSKIKEQNNRDIAGIKDklak 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    76 IREQSRKLQEIKEQEYQAQVEEMRlmmNQLEEDLVSARRRSDLYESELRESRL------AAEEFKRKATECQHKLLKAKD 149
Cdd:pfam12128  402 IREARDRQLAVAEDDLQALESELR---EQLEAGKLEFNEEEYRLKSRLGELKLrlnqatATPELLLQLENFDERIERARE 478

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   150 qgkpevgeyaKLEKINAEQqlkiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNR---------------- 213
Cdd:pfam12128  479 ----------EQEAANAEV----ERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhflrkea 544

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   214 EDSSEGIRKKLVEAEERR------------------HSLENKVKRL---------ETMERRENRLKDDIQTKSQQIQ--- 263
Cdd:pfam12128  545 PDWEQSIGKVISPELLHRtdldpevwdgsvggelnlYGVKLDLKRIdvpewaaseEELRERLDKAEEALQSAREKQAaae 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   264 -QMADKILELEEKHREAQVSAQHL--------------EVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 328
Cdd:pfam12128  625 eQLVQANGELEKASREETFARTALknarldlrrlfdekQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEE 704

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   329 AHEKGKILSEQK-----AMINAMDSKIRSLEQRIVELSEANKlAANSSLFTQ--RNMKAQ---EEMISELRQQKFYLETq 398
Cdd:pfam12128  705 QKEQKREARTEKqaywqVVEGALDAQLALLKAAIAARRSGAK-AELKALETWykRDLASLgvdPDVIAKLKREIRTLER- 782

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   399 agKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:pfam12128  783 --KIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSE 860


                   ....*.
gi 767972912   479 QLRQAK 484
Cdd:pfam12128  861 NLRGLR 866
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 190-535 9.51e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.07  E-value: 9.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   190 TELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSQQIQQMADK 268
Cdd:pfam19220   37 EAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRDK 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   269 ILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDS 348
Cdd:pfam19220  117 TAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTR 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   349 KIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishqd 420
Cdd:pfam19220  196 RLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------- 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   421 hsdknrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA 500
Cdd:pfam19220  264 ------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKA 333

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 767972912   501 LTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 535
Cdd:pfam19220  334 LAAKD-------AALERAEERIASLSDRIAELTKR 361
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 5-465 1.14e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.12  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     5 EMTRLHRRVSEVEAVLSQKEV---------ELKASETQRSLLE-----QDLATYIT---ECSSLKRSLEQARMEVSQEDD 67
Cdd:pfam05557    3 ELIESKARLSQLQNEKKQMELehkrarielEKKASALKRQLDResdrnQELQKRIRlleKREAEAEEALREQAELNRLKK 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    68 KALQLLHD-IREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESrlaaeEFKRKA 137
Cdd:pfam05557   83 KYLEALNKkLNEKESQLADAREvisclknelSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEA-----EQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   138 TECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQE---KLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 214
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELAripELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   215 DSSEGIRKKLVEAEERRHSLENKVK---RLETMERRENRLKDDIQTKSQQIQQmadkilelEEKHREAQVSAqhlevhLK 291
Cdd:pfam05557  238 EREEKYREEAATLELEKEKLEQELQswvKLAQDTGLNLRSPEDLSRRIEQLQQ--------REIVLKEENSS------LT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEkgkiLSEQKAMInamdSKIRSLEQRIVELSEANKLAANSS 371
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRR----LQRRVLLL----TKERDGYRAILESYDKELTMSNYS 375

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   372 LFTQRNMKAQEEMI-------SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEE 443
Cdd:pfam05557  376 PQLLERIEEAEDMTqkmqahnEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQeSLADPSYSKEEVDSLRRKLETLEL 455

                          490       500
                   ....*....|....*....|..
gi 767972912   444 QKLELKRQLTELQLSLQERESQ 465
Cdd:pfam05557  456 ERQRLREQKNELEMELERRCLQ 477
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
333-760 1.20e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 49.99  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  333 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 412
Cdd:COG5281     3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  413 LEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 492
Cdd:COG5281    83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  493 EAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 572
Cdd:COG5281   160 AAAAAAAAAAAAAAAAAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  573 EITE--REMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRMLDTEKQS 650
Cdd:COG5281   240 ASAAaqALAALAAAAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAAAAQLAAA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  651 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLE 730
Cdd:COG5281   317 AAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAGAKAALAE 391

                         410       420       430
                  ....*....|....*....|....*....|
gi 767972912  731 EQAKLQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:COG5281   392 YADSATNVAAQVAQAATSAFSGLTDALAGA 421
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 482-751 1.40e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 49.04  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   482 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND--- 558
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllk 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   559 -----------------EIVQLRSEVDHLRREITER----EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDElleker 617
Cdd:pfam15905  143 akfsedgtqkkmsslsmELMKLRNKLEAKMKEVMAKqegmEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE------ 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   618 qweawrsvlgdEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKL 697
Cdd:pfam15905  217 -----------EKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQI 277

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767972912   698 NDLEKKHAMLEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 751
Cdd:pfam15905  278 KDLNEKCKLLE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 339-542 1.45e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  339 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 418
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  419 QDHSDKNRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 491
Cdd:COG4942    98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  492 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 542
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
 78-306 1.65e-05

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 49.94  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    78 EQSRKLQEIKEQEYQAQVEEMR----LMMNQ----------LEEDLVSA----RRRSDLYESELRESRLAAEEFKRKATE 139
Cdd:pfam15818  119 EQKLQLHLLAKEDHHKQLNEIEkyyaTITGQfglvkenhgkLEQNVQEAiqlnKRLSALNKKQESEICSLKKELKKVTSD 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   140 cqhkLLKAKDQGKPEVGEyaklEKIN-AEQQLKIQELQEKL----EKAVKASTEAT-----------------ELLQNIR 197
Cdd:pfam15818  199 ----LIKSKVTCQYKMGE----ENINlTIKEQKFQELQERLnmelELNKKINEEIThiqeekqdiiisfqhmqQLLQQQT 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   198 QAKERAEREL----EKLQNREDSSEGIRKKLVEAEERRHSLENKvkrletMERRENRLKDDIQTKSQQIQQMADKILELE 273
Cdd:pfam15818  271 QANTEMEAELkalkENNQTLERDNELQREKVKENEEKFLNLQNE------HEKALGTWKKHVEELNGEINEIKNELSSLK 344

                          250       260       270
                   ....*....|....*....|....*....|...
gi 767972912   274 EKHREAQvsaqhlEVHLKQKEQHYEEKIKVLDN 306
Cdd:pfam15818  345 ETHIKLQ------EHYNKLCNQKKFEEDKKFQN 371
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 938-988 1.98e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 1.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767972912  938 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20824     1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 71-283 2.10e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   71 QLLHDIREQSRKLQEIKEQEYQAQVEemrlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQ 150
Cdd:COG4942    31 QLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  151 GKPEVGEYAKLEKI----------NAEQQLKIQELQEKLEKAVKASTEA-TELLQNIRQAKERAERELEKLQNREDSSEG 219
Cdd:COG4942   106 LAELLRALYRLGRQpplalllspeDFLDAVRRLQYLKYLAPARREQAEElRADLAELAALRAELEAERAELEALLAELEE 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  220 IRKKLVEAEERRHSLENKV-KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSA 283
Cdd:COG4942   186 ERAALEALKAERQKLLARLeKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
242-482 2.33e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.24  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  242 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 321
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  322 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyLETQA 399
Cdd:COG3206   242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ---LQQEA 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  400 GKLEAQnrkLEEQLEKISHQDHSDKNRLLELETRLREVSleheeqklELKRQLTELQLSLQERESQLTALQAARAALESQ 479
Cdd:COG3206   312 QRILAS---LEAELEALQAREASLQAQLAQLEARLAELP--------ELEAELRRLEREVEVARELYESLLQRLEEARLA 380


                  ...
gi 767972912  480 LRQ 482
Cdd:COG3206   381 EAL 383
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 201-641 2.75e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.18  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  201 ERAERELEKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS------QQIQQMADKI----- 269
Cdd:COG3096   278 NERRELSERALELRRELFGARRQLAEEQYR---LVEMARELEELSARESDLEQDYQAASdhlnlvQTALRQQEKIeryqe 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  270 --LELEEKHREAQ-VSAQHLEVHLKQKEQ--HYEEKIKVLDNQikkdLADKETLENMMQRheeeahekgKILSEQKAmin 344
Cdd:COG3096   355 dlEELTERLEEQEeVVEEAAEQLAEAEARleAAEEEVDSLKSQ----LADYQQALDVQQT---------RAIQYQQA--- 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  345 amdskIRSLEqRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkleaqnrkleeqlekishqdhsdk 424
Cdd:COG3096   419 -----VQALE-KARALCGLPDLTPENAEDYLAAFRAKEQQATE------------------------------------- 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  425 nRLLELETRLReVSLEHEEQkLELKRQLTELQLSLQEREsqlTALQAARAALEsQLRQAKTELEETtaeaeeeiQALTAH 504
Cdd:COG3096   456 -EVLELEQKLS-VADAARRQ-FEKAYELVCKIAGEVERS---QAWQTARELLR-RYRSQQALAQRL--------QQLRAQ 520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  505 RDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 584
Cdd:COG3096   521 LAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAAR 600

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972912  585 K----QTMEALKTTCTMLEEQVMDLEALND---ELLEKERQWEAWRSVLGDEKSQFECRVRELQ 641
Cdd:COG3096   601 ApawlAAQDALERLREQSGEALADSQEVTAamqQLLEREREATVERDELAARKQALESQIERLS 664
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 551-740 3.88e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  551 DEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLGDek 630
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE---IDKLQAEIAEAEAEIEERREELGE-- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  631 sqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKLNDLE 701
Cdd:COG3883    91 -----RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKLAELE 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767972912  702 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 740
Cdd:COG3883   161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 2-365 4.79e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.09  E-value: 4.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     2 MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSR 81
Cdd:TIGR04523  340 LNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    82 KLQEIkEQEYQaqveemrlmmNQLEEDLVSARRRSDLyESELRESRLAAEEFKRKATECQHKLLKAKDQgkpevgeyakL 161
Cdd:TIGR04523  420 EKELL-EKEIE----------RLKETIIKNNSEIKDL-TNQDSVKELIIKNLDNTRESLETQLKVLSRS----------I 477

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   162 EKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVeaeerrhSLENKVKRL 241
Cdd:TIGR04523  478 NKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS-------DLEDELNKD 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   242 ETMERRENrLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQI-------KKD 311
Cdd:TIGR04523  551 DFELKKEN-LEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEkekKDLIKEIEEKEKKISSLEKELekakkenEKL 629

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767972912   312 LADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 365
Cdd:TIGR04523  630 SSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMK 683
Filament pfam00038
Intermediate filament protein;
349-645 5.12e-05

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 47.22  E-value: 5.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   349 KIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRL 427
Cdd:pfam00038   19 KVRFLEQQNKLLeTKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDF-------RQKY 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   428 lELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE-------SQLRQAKTELEETTAEAEEEIQA 500
Cdd:pfam00038   92 -EDELNLRT---SAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKknheeevRELQAQVSDTQVNVEMDAARKLD 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   501 LTAHRDEIQRKFDALRNSCTviTDLEEQLNQLTEdnaELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQ 580
Cdd:pfam00038  168 LTSALAEIRAQYEEIAAKNR--EEAEEWYQSKLE---ELQ----------QAAARNGDALRSAKEEITELRRTIQSLEIE 232

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912   581 LTSQKQTMEALKTTCTMLEEQ-VMDLEALNDELLEKERQweawrsvLGDEKSQFECRVRELQRMLD 645
Cdd:pfam00038  233 LQSLKKQKASLERQLAETEERyELQLADYQELISELEAE-------LQETRQEMARQLREYQELLN 291
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 279-503 5.13e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  279 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 358
Cdd:COG3883     3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  359 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKNRLLELETR 433
Cdd:COG3883    83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  434 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 503
Cdd:COG3883   152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 157-334 5.15e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERR----- 231
Cdd:COG4942    35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  232 --------------HSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 297
Cdd:COG4942   115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 767972912  298 EEKIKVLD----------NQIKKDLADKETLENMMQRHEEEAHEKGK 334
Cdd:COG4942   195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 234-415 5.45e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 309
Cdd:COG3883    18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  310 -----------------KDLADKETLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 372
Cdd:COG3883    98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767972912  373 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 415
Cdd:COG3883   172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 938-989 5.87e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.10  E-value: 5.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767972912  938 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 989
Cdd:cd20798     1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1021-1066 6.53e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.88  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767972912 1021 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1066
Cdd:cd01242     2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
443-734 6.57e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  443 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 522
Cdd:COG1340     1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  523 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV 602
Cdd:COG1340    74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELEKAK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  603 MDLEaLNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvelavKEHKAEILALQQA 682
Cdd:COG1340   154 KALE-KNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA-------DELHKEIVEAQEK 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767972912  683 LKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 734
Cdd:COG1340   225 ADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 174-672 6.66e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 47.90  E-value: 6.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  174 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKK--LVEAEERRHSLE---------NKV---- 238
Cdd:PTZ00440 2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  239 -KRLETMERRENRLKDDIQTKSQQIQQmADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 311
Cdd:PTZ00440 2250 kKKLLDNKNKINNIKDKINDKEKELIN-VDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  312 LADKETLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 391
Cdd:PTZ00440 2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  392 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdknrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 471
Cdd:PTZ00440 2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  472 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 546
Cdd:PTZ00440 2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  547 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSqkqtmealkttctMLEEQVMDLEALNDELLEKERQweawrsvl 626
Cdd:PTZ00440 2531 DNSTYIINELESHVSKLNELLSYIDNEIKELENEKLK-------------LLEKAKIEESRKERERIESETQ-------- 2589

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 767972912  627 GDEKSQFECRVRELQRMLDTEKQsRARADQRITESRQVVELAVKEH 672
Cdd:PTZ00440 2590 EDNTDEEQINRQQQERLQKEEEQ-KAYSQERLNREVSGTDDTNKNH 2634
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3-357 7.31e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 7.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ--DLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQS 80
Cdd:COG4717    87 EEEYAELQEELEELEEELEELEAELEELREELEKLEKllQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELE 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   81 RKLQEIKE--------------------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE---LRESRLAAEEFKRKA 137
Cdd:COG4717   167 ELEAELAElqeeleelleqlslateeelQDLAEELEELQQRLAELEEELEEAQEELEELEEEleqLENELEAAALEERLK 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  138 TECQH----------------------------------------KLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQE 177
Cdd:COG4717   247 EARLLlliaaallallglggsllsliltiagvlflvlgllallflLLAREKASLGKEAEELQALPALEELEEEELEELLA 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  178 KLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLQNREDSSEGIRKKLVEAEErrhSLENKVKRLEtmerRENR 250
Cdd:COG4717   327 ALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDEE---ELRAALEQAE----EYQE 399

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  251 LKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEah 330
Cdd:COG4717   400 LKEELEELEEQLEELLGELEELLEALDEEE---------LEEELEELEEELEELEEELEELREELAELEAELEQLEED-- 468

                         410       420
                  ....*....|....*....|....*..
gi 767972912  331 ekgKILSEQKAMINAMDSKIRSLEQRI 357
Cdd:COG4717   469 ---GELAELLQELEELKAELRELAEEW 492
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 166-470 7.38e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 46.73  E-value: 7.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   166 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 244
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   245 ERRENRLKDDIQTK-SQQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKETLENMMQ 323
Cdd:pfam15905  131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   324 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 403
Cdd:pfam15905  196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   404 AQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam15905  261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
51-284 7.74e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.32  E-value: 7.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   51 LKRSLEQARMEVSQEDDKalqlLHDIREQSrKLQEIKEQE--YQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 128
Cdd:COG3206   180 LEEQLPELRKELEEAEAA----LEEFRQKN-GLVDLSEEAklLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  129 AAEEFKRKATecqhkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKA-STEATELLQNIRQAKERAEREL 207
Cdd:COG3206   255 ALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQlQQEAQRILASLEAELEALQARE 329

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912  208 EKLQNREDssegirkklveaeerrhSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQ 284
Cdd:COG3206   330 ASLQAQLA-----------------QLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVR 389
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1023-1138 7.78e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1023 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1099
Cdd:cd01243    15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767972912 1100 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1138
Cdd:cd01243    91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 937-987 8.27e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.27e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767972912  937 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20858     6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 940-988 8.53e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 8.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767972912  940 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20794     9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
mukB PRK04863
chromosome partition protein MukB;
254-567 8.56e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  254 DIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHyEEKIKVLDNqikkdladketlENMMQRHEEeAHEKG 333
Cdd:PRK04863  838 ELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL-LPRLNLLAD------------ETLADRVEE-IREQL 903

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  334 KILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 413
Cdd:PRK04863  904 DEAEEAKRFVQQHGNALAQLEPIVSVL------------------QSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVV 965

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  414 EKISHQDHSDKNRLL----ELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 489
Cdd:PRK04863  966 QRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQD 1045

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  490 T-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdnAELNNQNfylsKQLDEasgANDEIVQLRSEV 567
Cdd:PRK04863 1046 LgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE--AEMDNLT----KKLRK---LERDYHEMREQV 1111
46 PHA02562
endonuclease subunit; Provisional
 76-323 8.69e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.32  E-value: 8.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   76 IREQSrklQEIKEQEYQAQVEEMRLMM---NQLEEDLVSARRRSDL---YESELREsrlaAEEFKRKATECQHKLLK-AK 148
Cdd:PHA02562  176 IRELN---QQIQTLDMKIDHIQQQIKTynkNIEEQRKKNGENIARKqnkYDELVEE----AKTIKAEIEELTDELLNlVM 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  149 DQGKPEvgeyAKLEKINAEQ---QLKIQELQeKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegIRKKLV 225
Cdd:PHA02562  249 DIEDPS----AALNKLNTAAakiKSKIEQFQ-KVIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKE-------LQHSLE 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  226 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 305
Cdd:PHA02562  317 KLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKS 396

                         250
                  ....*....|....*...
gi 767972912  306 NqIKKDLADKETLENMMQ 323
Cdd:PHA02562  397 E-LVKEKYHRGIVTDLLK 413
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 345-514 8.99e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 8.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  345 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 424
Cdd:COG1579    14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  425 NRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 492
Cdd:COG1579    73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                         170       180
                  ....*....|....*....|..
gi 767972912  493 EAEEEIQALTAHRDEIQRKFDA 514
Cdd:COG1579   153 ELEAELEELEAEREELAAKIPP 174
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 454-813 9.34e-05

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 46.99  E-value: 9.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   454 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 529
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   530 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQTMEA- 590
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKKLEDl 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   591 --LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSRA----- 652
Cdd:pfam05622  148 gdLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLEEkleal 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   653 -RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMNAR---- 712
Cdd:pfam05622  224 qKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLGQEgsyr 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   713 ----SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKvkm 788
Cdd:pfam05622  304 erltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEAQSE--- 378

                          410       420
                   ....*....|....*....|....*
gi 767972912   789 egtISQQTKLIDFLQAKMDQPAKKK 813
Cdd:pfam05622  379 ---LQKKKEQIEELEPKQDSNLAQK 400
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 381-721 9.36e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 9.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   381 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELEtRLREVSLEHEEQKLELKRQLTELQlsLQ 460
Cdd:pfam17380  280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIR--QE 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   461 ERESQLTALQAARAALE-SQLRQAKTELEETTAEAEEEIQALTAHR------DEIQRKfdalrnsctvitdLEEQLNQLT 533
Cdd:pfam17380  357 ERKRELERIRQEEIAMEiSRMRELERLQMERQQKNERVRQELEAARkvkileEERQRK-------------IQQQKVEME 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   534 EDNAELNNQNFYLSKQLDEasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMD---LEALND 610
Cdd:pfam17380  424 QIRAEQEEARQREVRRLEE---------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDrkrAEEQRR 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   611 ELLEKErqWEAWRSVLGDEKSQfecrvrelQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEilaLQQALKEQKLKA 690
Cdd:pfam17380  495 KILEKE--LEERKQAMIEEERK--------RKLLEKEMEERQKAIYEEERRREAEEERRKQQEME---ERRRIQEQMRKA 561

                          330       340       350
                   ....*....|....*....|....*....|.
gi 767972912   691 ESLSDKLNDLEKKHAMLEMNARSLQQKLETE 721
Cdd:pfam17380  562 TEERSRLEAMEREREMMRQIVESEKARAEYE 592
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 455-774 1.07e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   455 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdALRNSCTVITDLEEQLNQLTE 534
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE---ELRQSREKHEELEEKYKELSA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   535 DNAELNNQNFYLSKQLDEASGandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLE 614
Cdd:pfam07888  109 SSEELSEEKDALLAQRAAHEA---RIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   615 KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEILALQQALKEQKLKAESLS 694
Cdd:pfam07888  186 ELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELRSLQERLNASERKVEGLG 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   695 DKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 763
Cdd:pfam07888  258 EELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337

                          330
                   ....*....|.
gi 767972912   764 KTERSDLEYQL 774
Cdd:pfam07888  338 RMEREKLEVEL 348
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 939-987 1.18e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  939 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20837     1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
637-891 1.23e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  637 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 708
Cdd:COG4913   213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  709 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 787
Cdd:COG4913   290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  788 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 867
Cdd:COG4913   358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                         250       260
                  ....*....|....*....|....
gi 767972912  868 EAAHRKATDHPHPSTPATARQQIA 891
Cdd:COG4913   427 EIASLERRKSNIPARLLALRDALA 450
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1497-1606 1.42e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912 1497 SGTEHHRGPSTSRSSPNKRGPPTynehiTKRVASSPAPPEGPSHPREPSTPH-RYREGRTELRRDKSPgrplerekspgr 1575
Cdd:PHA03307  343 PGPSPSRSPSPSRPPPPADPSSP-----RKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATG------------ 405

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767972912 1576 mlstRRERSPGRLFEDSSRGRLPAGAVRTPL 1606
Cdd:PHA03307  406 ----RFPAGRPRPSPLDAGAASGAFYARYPL 432
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 507-807 1.47e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.49  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  507 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITERE---- 578
Cdd:COG5185   233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTksid 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  579 -----MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 651
Cdd:COG5185   307 ikkatESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  652 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 731
Cdd:COG5185   387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  732 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 807
Cdd:COG5185   458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
mukB PRK04863
chromosome partition protein MukB;
433-760 1.52e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  433 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 512
Cdd:PRK04863  283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  513 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEV-DHLRR--EITEREMQLTSQKQTME 589
Cdd:PRK04863  355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAA---EEEVDELKSQLaDYQQAldVQQTRAIQYQQAVQALE 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  590 ALKTTC-----------TMLEEQVMDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQ 656
Cdd:PRK04863  425 RAKQLCglpdltadnaeDWLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARE 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  657 RITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 734
Cdd:PRK04863  501 LLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSE 576

                         330       340
                  ....*....|....*....|....*.
gi 767972912  735 LQQQMDLQKNHIFRLTQGLQEALDRA 760
Cdd:PRK04863  577 ARERRMALRQQLEQLQARIQRLAARA 602
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 939-990 1.58e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.58e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767972912  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd21094     3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 655-812 1.75e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  655 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 730
Cdd:COG1579    16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  731 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 809
Cdd:COG1579    89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                  ...
gi 767972912  810 AKK 812
Cdd:COG1579   169 AAK 171
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 339-771 1.86e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 46.20  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  339 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 416
Cdd:PRK10929   43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  417 SHQdHSDKNRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlesqLRQAKTEleetta 492
Cdd:PRK10929  115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLAQAQLT----ALQAESA------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  493 eaeeeiqALTAHRDEIqrkfdalrnsctvitdleeQLNQLTEDNAElnnqnfylskqldeasgandEIVQLRSEV----- 567
Cdd:PRK10929  184 -------ALKALVDEL-------------------ELAQLSANNRQ--------------------ELARLRSELakkrs 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  568 DHLRREITEREMQLTSQKQ--TMEALKTTcTMLEEQVMDLEALNDELLEKERQweawrsvLGDEKSQfecrvrELQRMLD 645
Cdd:PRK10929  218 QQLDAYLQALRNQLNSQRQreAERALEST-ELLAEQSGDLPKSIVAQFKINRE-------LSQALNQ------QAQRMDL 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  646 TEKQSRaRADQRITESRQVveLAVKEHKAEILALQQALKEqKLKAEslSDKLNDLEKKhamlemnarslqQKLETER-EL 724
Cdd:PRK10929  284 IASQQR-QAASQTLQVRQA--LNTLREQSQWLGVSNALGE-ALRAQ--VARLPEMPKP------------QQLDTEMaQL 345

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 767972912  725 K-QRLLEEQ--AKLQQQMDLQKNHIFRLTQGLQEALDraDLLKTERSDLE 771
Cdd:PRK10929  346 RvQRLRYEDllNKQPQLRQIRQADGQPLTAEQNRILD--AQLRTQRELLN 393
COG5022 COG5022
Myosin heavy chain [General function prediction only];
172-782 1.87e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 46.61  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  172 IQELQEKLEKavkasteatELLQNIRQAKERAERELEKLQNREDSSEgiRKKLVEAEERRHSLENKVKRLETMERRENRL 251
Cdd:COG5022   819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEVLIQKFGRSLK--AKKRFSLLKKETIYLQSAQRVELAERQLQEL 887

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  252 KDDIQTksqqIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKETLENMMQRHEEE 328
Cdd:COG5022   888 KIDVKS----ISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  329 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 406
Cdd:COG5022   964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  407 RKLEE--QLEKISHQDHSDKNRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 484
Cdd:COG5022  1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  485 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 564
Cdd:COG5022  1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  565 SEVDHLRREITEREMQLTSQKQTME--ALKTTCTMLEEQVMDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQ 641
Cdd:COG5022  1160 FWEANLEALPSPPPFAALSEKRLYQsaLYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEY 1236

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  642 RMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSL 714
Cdd:COG5022  1237 STSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSL 1308

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912  715 QQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 782
Cdd:COG5022  1309 RWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
159-250 1.88e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  159 AKLEKINAEQQLKIQELQEKLEKAvkaSTEATELLQNIRqAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV 238
Cdd:COG2433   423 ERLEAEVEELEAELEEKDERIERL---ERELSEARSEER-REIRKDREISRLDREIER---LERELEEERERIEELKRKL 495

                          90
                  ....*....|..
gi 767972912  239 KRLETMERRENR 250
Cdd:COG2433   496 ERLKELWKLEHS 507
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 220-616 1.91e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.00  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   220 IRKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSQQIQQMADKILELEEKHREAqvsAQHLEVH-------L 290
Cdd:pfam06160   65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   291 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 369
Cdd:pfam06160  138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   370 sslftQRNMKAQ----EEMISELRQQKFYLETQagkleaqnrKLEEQLEKISHQDHSDKNRLLELEtrlrevsLEHEEQK 445
Cdd:pfam06160  206 -----KTELPDQleelKEGYREMEEEGYALEHL---------NVDKEIQQLEEQLEENLALLENLE-------LDEAEEA 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   446 LE-LKRQLTELQLSLqEREsqltalqaaraalesqlrqakteleettaeaeeeIQAltahRDEIQRKFDALRNSctvITD 524
Cdd:pfam06160  265 LEeIEERIDQLYDLL-EKE----------------------------------VDA----KKYVEKNLPEIEDY---LEH 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   525 LEEQLNQLTEDNAELnNQNFYLS-KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 603
Cdd:pfam06160  303 AEEQNKELKEELERV-QQSYTLNeNELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQE 381

                          410
                   ....*....|....
gi 767972912   604 DL-EALNDelLEKE 616
Cdd:pfam06160  382 EFkESLQS--LRKD 393
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 935-988 1.92e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 1.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  935 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 988
Cdd:cd20828     2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 442-656 1.95e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  442 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---- 517
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  518 ---SCTVITDLEEQLNQltEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 594
Cdd:COG3883    95 lyrSGGSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912  595 ctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 656
Cdd:COG3883   173 ---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 30-229 2.04e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.59  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   30 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRlmmNQLEE 107
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaEAEAEIEERR---EELGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  108 DLVSARR--RSDLYESELRESRLAAEEFKR-----KATECQHKLLKA--KDQGKPEVGEyAKLEKINAEQQLKIQELQEK 178
Cdd:COG3883    91 RARALYRsgGSVSYLDVLLGSESFSDFLDRlsalsKIADADADLLEElkADKAELEAKK-AELEAKLAELEALKAELEAA 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  179 LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEE 229
Cdd:COG3883   170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 176-470 2.08e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   176 QEKLEKAVKasteatellQNIRQAKERAERELEKlqnredssegiRKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 255
Cdd:pfam17380  290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   256 QTKSQQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKETLENMMQRHEEEAHEKGK 334
Cdd:pfam17380  347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   335 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 414
Cdd:pfam17380  406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912   415 KISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 470
Cdd:pfam17380  464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 34-484 2.25e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   34 RSLLEQDLATYITECSSLK---RSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ-AQVEEMRLMMNQLEEDL 109
Cdd:COG5185   120 ISLLYLYKSEIVALKDELIkveKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKKLEIfGLTLGLLKGISELKKAE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  110 VSARRRSDLYESELRES------RLAAEEFKRKATEcqhKLLKAKDQGKPEVGEYA-KLEK-INAEQQLKIQELQEKLEK 181
Cdd:COG5185   200 PSGTVNSIKESETGNLGsestllEKAKEIINIEEAL---KGFQDPESELEDLAQTSdKLEKlVEQNTDLRLEKLGENAES 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  182 AVKASTEATELLQNIRQAKERAeRELEKLQNREDSSEGIRKKLVEAEERRHsLENKVKRLETMerrenrlkddIQTKSQQ 261
Cdd:COG5185   277 SKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEESKRETETG----------IQNLTAE 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  262 IQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQka 341
Cdd:COG5185   345 IEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQ-- 421

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  342 mINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLEtqagkLEAQNRKLEEQLEKIshqdh 421
Cdd:COG5185   422 -IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS-----VRSKKEDLNEELTQI----- 490

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912  422 sdKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAALESQLRQAK 484
Cdd:COG5185   491 --ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILALENLIPAS 548
PRK11281 PRK11281
mechanosensitive channel MscK;
434-751 2.34e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.06  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  434 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 510
Cdd:PRK11281   48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  511 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQKQT 587
Cdd:PRK11281  116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLKG 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  588 MEALKTTCTMLEEQVMDLE-ALNDELLEKERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrARADQRITESRQVV- 665
Cdd:PRK11281  182 GKVGGKALRPSQRVLLQAEqALLNAQNDLQRKSLEGNTQLQD--------LLQKQRDYLTARI--QRLEHQLQLLQEAIn 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  666 --ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQ--QMDL 741
Cdd:PRK11281  252 skRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLLKATEKLNTltQQNL 309

                         330
                  ....*....|.
gi 767972912  742 Q-KNHIFRLTQ 751
Cdd:PRK11281  310 RvKNWLDRLTQ 320
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 52-227 2.70e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.33  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    52 KRSLEQARMEVSQEDDKALQllHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV----SARRRSDLYESELRESR 127
Cdd:pfam15709  345 MRRLEVERKRREQEEQRRLQ--QEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQrqeeEERKQRLQLQAAQERAR 422

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   128 LAAEEFKRKATECQHKllkaKDQgkpEVGEYAKLEKiNAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 207
Cdd:pfam15709  423 QQQEEFRRKLQELQRK----KQQ---EEAERAEAEK-QRQKELEMQLAEEQKRLMEMAEEERLEYQRQKQEAEEKARLEA 494

                          170       180
                   ....*....|....*....|
gi 767972912   208 EKLQNREDssEGIRKKLVEA 227
Cdd:pfam15709  495 EERRQKEE--EAARLALEEA 512
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 937-987 2.80e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767972912  937 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20843    10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 162-362 3.46e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.30  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  162 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLQNREDSS-EGIRKKLVEAEERRHSLENK 237
Cdd:PRK05771   38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  238 VKRLETMERRENRLKD-DIqtksqqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------Q 307
Cdd:PRK05771  116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvV 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912  308 IKKDLADKetLENMMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 362
Cdd:PRK05771  185 VLKELSDE--VEEELKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 11-479 4.11e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 45.13  E-value: 4.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    11 RRVSEV-EAVLSQKEVELKasETQRSLLEQDLATYITECSSLKRSL-EQARMEVSQ-----EDDKALQLLHDIREQSRKL 83
Cdd:pfam07111  184 KRAGEAkQLAEAQKEAELL--RKQLSKTQEELEAQVTLVESLRKYVgEQVPPEVHSqtwelERQELLDTMQHLQEDRADL 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    84 QEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL-RESRLAAEEFKRKATECQHKLlKAKDqgkpevgeyakLE 162
Cdd:pfam07111  262 QATVEL-LQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFpKKCRSLLNRWREKVFALMVQL-KAQD-----------LE 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   163 KINAEQQLKIQ--ELQEKlekaVKASTEATELLQNIRQAKErAERELEKLqnredSSEGIRKKLVEAEERRHSLENKVKR 240
Cdd:pfam07111  329 HRDSVKQLRGQvaELQEQ----VTSQSQEQAILQRALQDKA-AEVEVERM-----SAKGLQMELSRAQEARRRQQQQTAS 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   241 LETMER----RENRLKDDIQTKSQQIQQMADKILELEEK--------HREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQ 307
Cdd:pfam07111  399 AEEQLKfvvnAMSSTQIWLETTMTRVEQAVARIPSLSNRlsyavrkvHTIKGLMARKVALaQLRQESCPPPPPAPPVDAD 478

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   308 IKKDLadkETLENMMQRHEEEAHEKGKILSEQKAminamdskiRSLEQRIVELSEANKLAANsslFTQRNMKAQEEMISE 387
Cdd:pfam07111  479 LSLEL---EQLREERNRLDAELQLSAHLIQQEVG---------RAREQGEAERQQLSEVAQQ---LEQELQRAQESLASV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   388 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSL-------- 459
Cdd:pfam07111  544 GQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLrqiqhrat 623

                          490       500
                   ....*....|....*....|..
gi 767972912   460 --QERESQLTALQAARAALESQ 479
Cdd:pfam07111  624 qeKERNQELRRLQDEARKEEGQ 645
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 933-987 4.19e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  933 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20859    14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
159-415 4.48e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.13  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  159 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 238
Cdd:COG1340    36 EELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLR 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  239 KRLETMERRenrlkddIQTKS---QQIQQMADKILELEEKHREAQvsaqhlevhlKQKEQHyeEKIKVLDNQIKKDLADK 315
Cdd:COG1340   116 KEIERLEWR-------QQTEVlspEEEKELVEKIKELEKELEKAK----------KALEKN--EKLKELRAELKELRKEA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  316 ETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftqrnMKAQEEMISELRQQKFYL 395
Cdd:COG1340   177 EEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEK--------------ADELHEEIIELQKELREL 242

                         250       260
                  ....*....|....*....|
gi 767972912  396 ETQAGKLEAQNRKLEEQLEK 415
Cdd:COG1340   243 RKELKKLRKKQRALKREKEK 262
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
76-393 5.28e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   76 IREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKP 153
Cdd:COG4372    33 LRKALFELDKLQEEleQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  154 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS 233
Cdd:COG4372   113 LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  234 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 313
Cdd:COG4372   193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKD 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  314 DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 393
Cdd:COG4372   273 TEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLD 352
COG5022 COG5022
Myosin heavy chain [General function prediction only];
3-773 5.79e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 44.68  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLATyitECSSLKRSL---EQARMEVSQEDDKALQLLHDI 76
Cdd:COG5022   799 LQPLLSLLGSRKEYRSYLACiikLQKTIKREKKLRETEEVEFSL---KAEVLIQKFgrsLKAKKRFSLLKKETIYLQSAQ 875

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   77 REQS--RKLQEIKEQEyqAQVEEMRLMMNQLEEDLVsaRRRSDLYESELRESRLAAEEFKRkaTECQHKLLKAKDQGKPE 154
Cdd:COG5022   876 RVELaeRQLQELKIDV--KSISSLKLVNLELESEII--ELKKSLSSDLIENLEFKTELIAR--LKKLLNNIDLEEGPSIE 949

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  155 VGEYAKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLQNREDSSEGIRKKLVEAEERRHSL 234
Cdd:COG5022   950 YVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSKQYGAL 1011

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  235 ENKVKRLETMERRENRLKDDIQTKSQqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIkkdlad 314
Cdd:COG5022  1012 QESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR------ 1073

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  315 ketlenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselrQQKFY 394
Cdd:COG5022  1074 ----------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ---------MIKLN 1126

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  395 LETQAGKLEAQNRKLEEQLEKishqdhSDKNRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTALQAARA 474
Cdd:COG5022  1127 LLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALYDEKSK 1193

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  475 ALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAS 554
Cdd:COG5022  1194 LSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPAS 1255

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  555 GANDEIVQLRSEVDHLRRE-ITEREMQLTSQKQTMealkttctmleeQVMDLEALNdELLEKERQWEaWRSVLGDEKSQF 633
Cdd:COG5022  1256 MSNEKLLSLLNSIDNLLSSyKLEEEVLPATINSLL------------QYINVGLFN-ALRTKASSLR-WKSATEVNYNSE 1321

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  634 E----CRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLNDLEKK 703
Cdd:COG5022  1322 ElddwCREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKENNLPKE 1393

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972912  704 HaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 773
Cdd:COG5022  1394 I-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
PRK09039 PRK09039
peptidoglycan -binding protein;
565-698 5.99e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.80  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  565 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELlekerqwEAWRSVLGDEKSQFECRVRELQRML 644
Cdd:PRK09039   53 SALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQEL 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912  645 DTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 698
Cdd:PRK09039  126 DSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 520-739 6.12e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  520 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL---- 591
Cdd:COG3883    16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaral 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  592 ---KTTCTMLEeQVMDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG3883    96 yrsGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAA 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912  669 VKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 739
Cdd:COG3883   170 KAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
545-780 6.16e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  545 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS--QKQTMEALKTTCTMLEEQVMDLE----ALNDELLEKER 617
Cdd:COG3206   161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELEsqlaEARAELAEAEA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  618 QWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQKLKAe 691
Cdd:COG3206   241 RLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEAQRI- 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  692 slsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTERSdle 771
Cdd:COG3206   315 -----LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAEA--- 382


                  ....*....
gi 767972912  772 YQLENIQVL 780
Cdd:COG3206   383 LTVGNVRVI 391
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 950-987 6.77e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 6.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767972912  950 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20831    17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 3-407 7.05e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 7.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLeqarmevsQEDDKALQLLHDIREQSrk 82
Cdd:pfam10174  393 ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEAL--------SEKERIIERLKEQRERE-- 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    83 lqeikEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 162
Cdd:pfam10174  463 -----DRERLEELESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLE 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   163 KinaeQQLKIQElqekLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIrkkLVEAEERRHSLENKVKRLE 242
Cdd:pfam10174  538 N----QLKKAHN----AEEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGI---LREVENEKNDKDKKIAELE 606

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   243 TMERRenrlkddiQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlaDKETLENMM 322
Cdd:pfam10174  607 SLTLR--------QMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEK---TRQELDATK 675

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   323 QRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS---------SLFTQRNMKAQEEMISeLRQQKF 393
Cdd:pfam10174  676 ARLSSTQQS----LAEKDGHLTNLRAERRKQLEEILEMKQEALLAAISekdaniallELSSSKKKKTQEEVMA-LKREKD 750

                          410
                   ....*....|....
gi 767972912   394 YLETQAgKLEAQNR 407
Cdd:pfam10174  751 RLVHQL-KQQTQNR 763
46 PHA02562
endonuclease subunit; Provisional
 645-804 7.47e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  645 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 715
Cdd:PHA02562  202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  716 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 785
Cdd:PHA02562  282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                         170
                  ....*....|....*....
gi 767972912  786 vkmEGTISQQTKLIDFLQA 804
Cdd:PHA02562  357 ---VDKAKKVKAAIEELQA 372
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 451-668 8.01e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  451 QLTELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQRKFDALRNSctvITDLEEQLN 530
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEE-----------YNELQAELEALQAEIDKLQAE---IAEAEAEIE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  531 QLTEDNAELNNQNF---YLSKQLDEASGANDeIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEA 607
Cdd:COG3883    83 ERREELGERARALYrsgGSVSYLDVLLGSES-FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972912  608 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 668
Cdd:COG3883   162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 191-630 8.99e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   191 ELLQNIRQAKERAERELekLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSQQIQQMADKIL 270
Cdd:pfam07888   30 ELLQNRLEECLQERAEL--LQAQEAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   271 ELEEKHREAQVS----AQHLEVHLKQKEQHyEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM 346
Cdd:pfam07888   98 ELEEKYKELSASseelSEEKDALLAQRAAH-EARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQL 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   347 DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyleTQAGKLEAQNRKLEEQLEKISHQDHSDKNR 426
Cdd:pfam07888  177 QAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKL----TTAHRKEAENEALLEELRSLQERLNASERK 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   427 LLELETRLREVSLEHEEQKLELKR-QLTELQLSLQERESQLtALQAARAalesQLRQAKTELEETTAEAEEEIQALTAhr 505
Cdd:pfam07888  253 VEGLGEELSSMAAQRDRTQAELHQaRLQAAQLTLQLADASL-ALREGRA----RWAQERETLQQSAEADKDRIEKLSA-- 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   506 dEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqldeasgandeiVQLRSEVDHLRREITEREMQLTSQK 585
Cdd:pfam07888  326 -ELQRL--------------EERLQEERMEREKLE--------------------VELGREKDCNRVQLSESRRELQELK 370

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*
gi 767972912   586 QTMEALKTTctmlEEQvmdLEALNDELLEKERQWEAWRSVLGDEK 630
Cdd:pfam07888  371 ASLRVAQKE----KEQ---LQAEKQELLEYIRQLEQRLETVADAK 408
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 52-478 8.99e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 43.73  E-value: 8.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    52 KRSLEQARMEVSQEDD----KALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvsarrrsdlyesELRESR 127
Cdd:pfam07888   28 RAELLQNRLEECLQERaellQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE--------------ELRQSR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   128 LAAEEFKRKATEcqhkllkAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEK-AVKASTEATELlqniRQAKERAERE 206
Cdd:pfam07888   94 EKHEELEEKYKE-------LSASSEELSEEKDALLAQRAAHEARIRELEEDIKTlTQRVLERETEL----ERMKERAKKA 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   207 LEKLQNREDSSEGIRKKLVEAEERRHSLENKVKrletmerrenRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhl 286
Cdd:pfam07888  163 GAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQ----------ELRNSLAQRDTQVLQLQDTITTLTQKLTTAH------ 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   287 evhlkQKEQHYEekikvldnQIKKDLADKETLENMMQRHEEeahekgKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 366
Cdd:pfam07888  227 -----RKEAENE--------ALLEELRSLQERLNASERKVE------GLGEELSSMAAQRDRTQAELHQARLQAAQLTLQ 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   367 AANSSLF--------------TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL--EKISH--QDHSDKNRLL 428
Cdd:pfam07888  288 LADASLAlregrarwaqeretLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELgrEKDCNrvQLSESRRELQ 367

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 767972912   429 ELETRLReVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 478
Cdd:pfam07888  368 ELKASLR-VAQKEKEQLQAEKQELLEYIRQLEQRLETVADAKWSEAALTS 416
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 211-299 9.45e-04

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 41.18  E-value: 9.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   211 QNREDSSEGIRKKLVEAEERRHSLE-NKVKRL-ETMER-RENRLKDDIQTK--SQQIQQMADKILELEEKHREAQVSAqh 285
Cdd:pfam00836   38 KKKDSSLEEIQKKLEAAEERRKSLEaQKLKQLaEKREKeEEALQKADEENNnfSKMAEEKLKQKMEAYKENREAQIAA-- 115

                           90
                   ....*....|....
gi 767972912   286 LEVHLKQKEQHYEE 299
Cdd:pfam00836  116 LKEKLKEKEKHVEE 129
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 292-820 9.81e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 9.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   292 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEAnklaANSS 371
Cdd:pfam12128  237 MKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASR---QEERQETSAELNQLLRTLDDQWKEKRDE----LNGE 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   372 LFTQRnmkaqeEMISELRQQKFYLETQAGKLE---AQNRKLE-EQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE 447
Cdd:pfam12128  310 LSAAD------AAVAKDRSELEALEDQHGAFLdadIETAAADqEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSK 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   448 LKRQLT--------ELQLSLQERESQLTALQAARAALESQLRQAKTeleettaeaeeeiQALTAHRDEIQRKFDALRNSC 519
Cdd:pfam12128  384 IKEQNNrdiagikdKLAKIREARDRQLAVAEDDLQALESELREQLE-------------AGKLEFNEEEYRLKSRLGELK 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   520 TVITDL---EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK---- 592
Cdd:pfam12128  451 LRLNQAtatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELElqlf 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   593 ----TTCTMLEEQVMDLE-----ALNDELLEK-ERQWEAWRSVLGDEKSQFECRVReLQRM-----LDTEKQSRARADQr 657
Cdd:pfam12128  531 pqagTLLHFLRKEAPDWEqsigkVISPELLHRtDLDPEVWDGSVGGELNLYGVKLD-LKRIdvpewAASEEELRERLDK- 608

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   658 itesrqvvelaVKEhkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 737
Cdd:pfam12128  609 -----------AEE------ALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNK 671

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   738 QmdlqknhifrLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLF 817
Cdd:pfam12128  672 A----------LAERKDSANERLNSLEAQLKQLDKKHQ--AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIA 739


                   ...
gi 767972912   818 SRR 820
Cdd:pfam12128  740 ARR 742
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 124-468 1.09e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  124 RESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA 203
Cdd:PTZ00440  435 LYSNLEIIEIKKKYDEKINELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEKVDELLQIINSIKEKN 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  204 ERELEKLQNREDSS---EGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ 280
Cdd:PTZ00440  515 NIVNNNFKNIEDYYitiEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEENVDHIKDIISLNDEID 594

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  281 VSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLadKETLENMMQRH-EEEAHEKGKILSEQKAMINAMDSKirsleQRIVE 359
Cdd:PTZ00440  595 NIIQQIE-ELINEALFNKEKFINEKNDLQEKV--KYILNKFYKGDlQELLDELSHFLDDHKYLYHEAKSK-----EDLQT 666

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  360 L-----SEANKLA-ANSSLFTQ--RNMKAQEEMISELRQQkfyletqagkleaqnrKLEEQLEKIsHQDHSDK-NRLLEL 430
Cdd:PTZ00440  667 LlntskNEYEKLEfMKSDNIDNiiKNLKKELQNLLSLKEN----------------IIKKQLNNI-EQDISNSlNQYTIK 729

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 767972912  431 ETRLREV--SLEHEEQKLELKRQ-----LTELQLSLQERESQLTA 468
Cdd:PTZ00440  730 YNDLKSSieEYKEEEEKLEVYKHqiinrKNEFILHLYENDKDLPD 774
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 166-391 1.19e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  166 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV-KRLETM 244
Cdd:COG3883    19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK---LQAEIAEAEAEIEERREELgERARAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  245 ERRENRLKD-DIQTKSQQIQQMADKILELEekhreaQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKETLENMMQ 323
Cdd:COG3883    96 YRSGGSVSYlDVLLGSESFSDFLDRLSALS------KIADADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELE 167

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912  324 RHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 391
Cdd:COG3883   168 AAKAELEAQ---QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 4-301 1.28e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     4 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKL 83
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV 512

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    84 QEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARR---------RSDLYESELRESRLAAEEFKrkatECQHKLLKAKDQGK 152
Cdd:TIGR04523  513 KDLTKKisSLKEKIEKLESEKKEKESKISDLEDelnkddfelKKENLEKEIDEKNKEIEELK----QTQKSLKKKQEEKQ 588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   153 PEVGEYAK----LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDsseGIRKKLVEAE 228
Cdd:TIGR04523  589 ELIDQKEKekkdLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIK---EIRNKWPEII 665

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   229 ERRHSLENKV-KRLETMERREN----RLKDDI--QTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKI 301
Cdd:TIGR04523  666 KKIKESKTKIdDIIELMKDWLKelslHYKKYItrMIRIKDLPKLEEKYKEIEKELKKLDEFSKELENIIKNFNKKFDDAF 745
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 939-990 1.33e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.41  E-value: 1.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767972912  939 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20809     1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 939-992 1.38e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  939 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 992
Cdd:cd20864     3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 4-237 1.42e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.88  E-value: 1.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     4 QEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQE-DDKALQLLHDIREQSRK 82
Cdd:pfam15905   87 QERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNELLKAKFSEDgTQKKMSSLSMELMKLRN 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    83 LQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKATECQHKLLKAKDQGKPEVGEYA 159
Cdd:pfam15905  167 KLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKsetEKLLEYITELSCVSEQVEKYKLDIA 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   160 KLEKINAEQQLKIQELQEKL-EKAVKAST---EATELLQNIRQAKERAEREL-EKLQNREDSSEGIRKKLVEAEERRHSL 234
Cdd:pfam15905  247 QLEELLKEKNDEIESLKQSLeEKEQELSKqikDLNEKCKLLESEKEELLREYeEKEQTLNAELEELKEKLTLEEQEHQKL 326


                   ...
gi 767972912   235 ENK 237
Cdd:pfam15905  327 QQK 329
46 PHA02562
endonuclease subunit; Provisional
 503-703 1.48e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  503 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----NDEIVQLRSEVDHLRREITERE 578
Cdd:PHA02562  213 ENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNTAAAKIKSKIEQFQKVIKMYE 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  579 ---------MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQRMLDTEKQ 649
Cdd:PHA02562  283 kggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK-----------KLLELKNKISTNKQ 351

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912  650 SRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKLNDLEKK 703
Cdd:PHA02562  352 SLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTKSELVKE 401
PLN02939 PLN02939
transferase, transferring glycosyl groups
 2-238 1.50e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    2 MEQEMTRLHRRVSEVEA---VLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEqarMEVSQEDDKALQLLHDIRE 78
Cdd:PLN02939  168 LQGKINILEMRLSETDArikLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLS---KELDVLKEENMLLKDDIQF 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   79 QSRKLQEIKE-QEYQAQVEEMRLMMNQLEEDLVSarRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQgkpeVGE 157
Cdd:PLN02939  245 LKAELIEVAEtEERVFKLEKERSLLDASLRELES--KFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQ----VEK 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  158 YAKLEKINAEQQLKIQELQEKLEKAV--KASTEATELLQN-IRQAKERAER-------ELEKLQNREDSSEGIRKKLVEA 227
Cdd:PLN02939  319 AALVLDQNQDLRDKVDKLEASLKEANvsKFSSYKVELLQQkLKLLEERLQAsdheihsYIQLYQESIKEFQDTLSKLKEE 398

                         250
                  ....*....|.
gi 767972912  228 EERRhSLENKV 238
Cdd:PLN02939  399 SKKR-SLEHPA 408
46 PHA02562
endonuclease subunit; Provisional
 240-539 1.62e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  240 RLETMERREnRLKD--DIQTKSQqiqqMaDKILEleEKHREAQVSAQHLEV---HLKQKEQHYEEKIKVLDNQIKKDLAD 314
Cdd:PHA02562  146 QLSAPARRK-LVEDllDISVLSE----M-DKLNK--DKIRELNQQIQTLDMkidHIQQQIKTYNKNIEEQRKKNGENIAR 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  315 KEtleNMMQRHEEEAhekgkilseqkamiNAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEEMISELRQQKF 393
Cdd:PHA02562  218 KQ---NKYDELVEEA--------------KTIKAEIEELTDELLNLVmDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKM 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  394 YLETQAGKLEAQNrkLEEQLEKIShqdhSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 473
Cdd:PHA02562  281 YEKGGVCPTCTQQ--ISEGPDRIT----KIKDKLKELQHSLEKLD-TAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912  474 AALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 539
Cdd:PHA02562  354 ITLVDKAKKVK---------------------AAIEELQAEFVDNAEELAKLQDELDKIVKTKSEL 398
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 84-481 1.63e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.12  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   84 QEIKEQE-----YQAQ-VEEMRLMMNQLEEDLVSARRrsdlyeseLRESRLAAEEFKRKATECQHKLLKAKDQGKPevge 157
Cdd:PRK10929   30 QELEQAKaaktpAQAEiVEALQSALNWLEERKGSLER--------AKQYQQVIDNFPKLSAELRQQLNNERDEPRS---- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  158 yaklekinAEQQLKIQELQEKLekaVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENK 237
Cdd:PRK10929   98 --------VPPNMSTDALEQEI---LQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGTP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  238 VKRLEtmerrenrlkdDIQTKSQQIQQMADKIL--ELEEkhreAQVSA---QHL-----EVHLKQKEQhyeekikvLDNQ 307
Cdd:PRK10929  167 NTPLA-----------QAQLTALQAESAALKALvdELEL----AQLSAnnrQELarlrsELAKKRSQQ--------LDAY 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  308 IKkdlADKETLENMMQRHEEEAHEKGKILSEQKAminAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMIs 386
Cdd:PRK10929  224 LQ---ALRNQLNSQRQREAERALESTELLAEQSG---DLPKSIVAQFKINRELSQAlNQQAQRMDLIASQQRQAASQTL- 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  387 ELRQQKFYLETQAGKLEAQN---RKLEEQLEKIshqdhSDKNRLLELET---RLREVSLEHEEQkLELKRQLTELQlslQ 460
Cdd:PRK10929  297 QVRQALNTLREQSQWLGVSNalgEALRAQVARL-----PEMPKPQQLDTemaQLRVQRLRYEDL-LNKQPQLRQIR---Q 367

                         410       420
                  ....*....|....*....|.
gi 767972912  461 ERESQLTALQaaRAALESQLR 481
Cdd:PRK10929  368 ADGQPLTAEQ--NRILDAQLR 386
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 939-986 1.72e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767972912  939 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 986
Cdd:cd20888     6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
mukB PRK04863
chromosome partition protein MukB;
120-376 1.72e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  120 ESELRESRLAAEEFKRKATECQHKLLKAK---DQGKPEVGEYAKLE---KINAEQQL--KIQELQEKLEKAvkasTEATE 191
Cdd:PRK04863  836 EAELRQLNRRRVELERALADHESQEQQQRsqlEQAKEGLSALNRLLprlNLLADETLadRVEEIREQLDEA----EEAKR 911

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  192 LLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRL-ETMERRENRLKDDIQTKSQQIQQMADKil 270
Cdd:PRK04863  912 FVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALtEVVQRRAHFSYEDAAEMLAKNSDLNEK-- 989

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  271 eLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDN-----QIKKDLAD--KETLENMMQRHEEEAHEKGKILSEQ-KAM 342
Cdd:PRK04863  990 -LRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASlkssyDAKRQMLQelKQELQDLGVPADSGAEERARARRDElHAR 1068

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 767972912  343 INAMDSKIRSLEQRIV----ELSEANKL--AANSSLFTQR 376
Cdd:PRK04863 1069 LSANRSRRNQLEKQLTfceaEMDNLTKKlrKLERDYHEMR 1108
PRK12704 PRK12704
phosphodiesterase; Provisional
 251-450 1.79e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.84  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  251 LKDDIQTKSQQIQQMADKILEleEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKET----LENMMQRHE 326
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILE--EAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRERRNelqkLEKRLLQKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  327 EeahekgkilseqkaminAMDSKIRSLEQRIVELseanklaansslftqrnmkaqEEMISELRQQKFYLETQAGKLEAQN 406
Cdd:PRK12704   96 E-----------------NLDRKLELLEKREEEL---------------------EKKEKELEQKQQELEKKEEELEELI 137

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  407 RKLEEQLEKISHQDHSD-KNRLLE-LETRLRE-----VSLEHEEQKLELKR 450
Cdd:PRK12704  138 EEQLQELERISGLTAEEaKEILLEkVEEEARHeaavlIKEIEEEAKEEADK 188
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 20-184 1.84e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   20 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyQAQVEEMR 99
Cdd:COG1579    12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRNNK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  100 lMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEyakLEKINAEQQLKIQELQEKL 179
Cdd:COG1579    90 -EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAER 165


                  ....*
gi 767972912  180 EKAVK 184
Cdd:COG1579   166 EELAA 170
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 450-872 1.85e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.12  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  450 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 524
Cdd:PRK10929    2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  525 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTsQKQTmEALKt 593
Cdd:PRK10929   82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLP-QQQT-EARR- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  594 tctMLEEQVMDLEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQrmldtekQSRARADQRITESRQVVELAVKEHk 673
Cdd:PRK10929  152 ---QLNEIERRLQTLGTPNTPLA---QAQLTALQAESAALKALVDELE-------LAQLSANNRQELARLRSELAKKRS- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  674 AEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrLLEEQAklqQQMDL 741
Cdd:PRK10929  218 QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-ALNQQA---QRMDL 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  742 ----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKL 798
Cdd:PRK10929  284 iasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPQL 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  799 IDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTRielrsareEAAHR 872
Cdd:PRK10929  363 RQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN--------EATHR 429
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 934-987 1.89e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 37.65  E-value: 1.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  934 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20822     3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
21-322 2.04e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.21  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   21 SQKEVELKASE--TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVE 96
Cdd:COG1340     9 SLEELEEKIEElrEEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEErdELNEKLN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   97 EMRLMMNQLEEDLvsarrrsdlyeSELRESRLAAEEFKRkatecqhkllkakdqgkpevgEYAKLEK--------INAEQ 168
Cdd:COG1340    89 ELREELDELRKEL-----------AELNKAGGSIDKLRK---------------------EIERLEWrqqtevlsPEEEK 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  169 QL--KIQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLenkVKRLET 243
Cdd:COG1340   137 ELveKIKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADE 213

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  244 MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKKdlADKETLENMM 322
Cdd:COG1340   214 LHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK--GEKLTTEELK 288
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 522-702 2.13e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.71  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   522 ITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 601
Cdd:pfam05667  337 LEELQEQLEDLESSIQELE----------KEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKL 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   602 VMDLEALNDELLEKERQWEAWRSVLGDEksqfecrVRELqrmldtekqsRARADQRITESRQVVElAVKEHKAEIlalQQ 681
Cdd:pfam05667  407 QALVDASAQRLVELAGQWEKHRVPLIEE-------YRAL----------KEAKSNKEDESQRKLE-EIKELREKI---KE 465

                          170       180
                   ....*....|....*....|.
gi 767972912   682 ALKEQKLKAESLSDKLNDLEK 702
Cdd:pfam05667  466 VAEEAKQKEELYKQLVAEYER 486
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
3-210 2.27e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    3 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ---------DLATYITECSS-----------------LKRSLE 56
Cdd:COG4913   616 EAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAEleaelerldassddlaaLEEQLE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   57 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEM-------------------------RLMMNQLEEDL 109
Cdd:COG4913   696 ELEAELEELEEELDELKGEIGRLEKELEQAEEEldELQDRLEAAedlarlelralleerfaaalgdaveRELRENLEERI 775

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  110 VSARRRSDLYESELREsrlAAEEFKRKATECQHKLlkakDQGKPEVGEY-AKLEKINAEqqlKIQELQEKLEKAVKASTE 188
Cdd:COG4913   776 DALRARLNRAEEELER---AMRAFNREWPAETADL----DADLESLPEYlALLDRLEED---GLPEYEERFKELLNENSI 845

                         250       260
                  ....*....|....*....|....
gi 767972912  189 A--TELLQNIRQAKERAERELEKL 210
Cdd:COG4913   846 EfvADLLSKLRRAIREIKERIDPL 869
PLN02939 PLN02939
transferase, transferring glycosyl groups
 197-471 2.45e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.58  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  197 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRlETMERRENRLKDDIQTKSQQIQQmADKILELEEKH 276
Cdd:PLN02939   38 RRRGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLR-TVMELPQKSTSSDDDHNRASMQR-DEAIAAIDNEQ 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  277 RE-----AQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEtlenmmqrheeeahekgKILSEQKAMinamDSKIR 351
Cdd:PLN02939  116 QTnskdgEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE-----------------KILTEKEAL----QGKIN 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  352 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkLEEQLEKISHQDHSDKNRLLELE 431
Cdd:PLN02939  174 ILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----LSKELDVLKEENMLLKDDIQFLK 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 767972912  432 TRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 471
Cdd:PLN02939  247 AELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 4-283 2.58e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 42.63  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    4 QEMTRLHRRVSE------VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ-----------ED 66
Cdd:COG3096   809 QKLQRLHQAFSQfvgghlAVAFAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqanllAD 888

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   67 DKALQLLHDIREQSRKLQEIKE--QEYQAQVEEMrlmmnqleEDLVSARRRSDLYESELRESRLAAEEfKRKATECQHKL 144
Cdd:COG3096   889 ETLADRLEELREELDAAQEAQAfiQQHGKALAQL--------EPLVAVLQSDPEQFEQLQADYLQAKE-QQRRLKQQIFA 959

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  145 LKAKDQGKPEVGeYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI-----------------RQAKER----A 203
Cdd:COG3096   960 LSEVVQRRPHFS-YEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAqaqysqynqvlaslkssRDAKQQtlqeL 1038

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  204 ERELEKLQNREDSSEGIRkklveAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQ 280
Cdd:COG3096  1039 EQELEELGVQADAEAEER-----ARIRRDELHEELSQNRS---RRSQLEKQLTRCEAEMDSLQKRLRKAERDYkqeREQV 1110


                  ...
gi 767972912  281 VSA 283
Cdd:COG3096  1111 VQA 1113
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 459-615 2.70e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 40.69  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   459 LQERESQLTALQAA-RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTvitDLEEQLNQLTEDNA 537
Cdd:pfam08614   12 LLDRTALLEAENAKlQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRG---ELAQRLVDLNEELQ 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912   538 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEK 615
Cdd:pfam08614   89 ELEKKLREDERRLAALE---AERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENRELVER 163
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 63-324 2.74e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    63 SQEDDKALQLL-HDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARR---RSDLYESELRESRLAAEEFKRKAT 138
Cdd:TIGR01612 1445 ADENNENVLLLfKNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGckdEADKNAKAIEKNKELFEQYKKDVT 1524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   139 ECQHKL----LKAK-DQGKP-------EVGEYAK---LEKINAEQQL-KIQELQEKLEKAVKASTEATELLQNIRQAKER 202
Cdd:TIGR01612 1525 ELLNKYsalaIKNKfAKTKKdseiiikEIKDAHKkfiLEAEKSEQKIkEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLEN 1604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   203 AERELEKLQNredssegIRKKLVEAEERRHSLENKVK---------RLETMERRENRLKDDIQTKSQQIQQMADKILELE 273
Cdd:TIGR01612 1605 FENKFLKISD-------IKKKINDCLKETESIEKKISsfsidsqdtELKENGDNLNSLQEFLESLKDQKKNIEDKKKELD 1677

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767972912   274 EKHREaqvsAQHLEVHLKQKEQHYE----EKIKVLDNQIKKDL-ADKETLENMMQR 324
Cdd:TIGR01612 1678 ELDSE----IEKIEIDVDQHKKNYEigiiEKIKEIAIANKEEIeSIKELIEPTIEN 1729
PRK12704 PRK12704
phosphodiesterase; Provisional
 654-790 2.79e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  654 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 733
Cdd:PRK12704   62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  734 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 790
Cdd:PRK12704  139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
50-256 3.11e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   50 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQL--------EEDLVSARRRSDLYES 121
Cdd:COG4717   320 ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagvedEEELRAALEQAEEYQE 399

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  122 ELRESRLAAEEFKRKATECQHKLlkakdqgkpevgEYAKLEKINAEqqlkIQELQEKLEkavkastEATELLQNIRQAKE 201
Cdd:COG4717   400 LKEELEELEEQLEELLGELEELL------------EALDEEELEEE----LEELEEELE-------ELEEELEELREELA 456

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767972912  202 RAERELEKLQNREDSSEgIRKKLVEAEERRHSLENKVKRL----ETMERRENRLKDDIQ 256
Cdd:COG4717   457 ELEAELEQLEEDGELAE-LLQELEELKAELRELAEEWAALklalELLEEAREEYREERL 514
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 57-434 3.57e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.08  E-value: 3.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    57 QARME--VSQEDDKAlQLLHDIrEQSRKLQEikeqeyqAQVEEMRLMMNQLEEDLVS---ARRRSDL--------YESEL 123
Cdd:pfam01576  663 RAEMEdlVSSKDDVG-KNVHEL-ERSKRALE-------QQVEEMKTQLEELEDELQAtedAKLRLEVnmqalkaqFERDL 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   124 RESRLAAEEFKR----KATECQHKLLKAKDQGKPEVGEYAKLEkinaeqqLKIQELQEKLEKAVKASTEATELLQNIRQA 199
Cdd:pfam01576  734 QARDEQGEEKRRqlvkQVRELEAELEDERKQRAQAVAAKKKLE-------LDLKELEAQIDAANKGREEAVKQLKKLQAQ 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   200 KERAERELEKLQNredSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQ---------------- 263
Cdd:pfam01576  807 MKDLQRELEEARA---SRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELAdeiasgasgksalqde 883

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   264 --QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKETLENMMQRHEEEAHE--------KG 333
Cdd:pfam01576  884 krRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQ----LTTELAAERSTSQKSESARQQLERQNKElkaklqemEG 959

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   334 KILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMI--------------------SELRQQKF 393
Cdd:pfam01576  960 TVKSKFKSSIAALEAKIAQLEEQLEQ--ESRERQAANKLVRRTEKKLKEVLLqvederrhadqykdqaekgnSRMKQLKR 1037

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 767972912   394 YL---ETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 434
Cdd:pfam01576 1038 QLeeaEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 172-299 3.68e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.12  E-value: 3.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  172 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDssegirKKLVEAEERrhsLENKVKrlETMERRENRL 251
Cdd:PRK00409  522 IASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEED------KLLEEAEKE---AQQAIK--EAKKEADEII 590

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767972912  252 KDDIQTKSQQIQQMADKilELEEKHREAQVSAQHLEVHLKQKEQHYEE 299
Cdd:PRK00409  591 KELRQLQKGGYASVKAH--ELIEARKRLNKANEKKEKKKKKQKEKQEE 636
mukB PRK04863
chromosome partition protein MukB;
552-872 3.74e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  552 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEeqvMDLEALNDEL---LEKERQWEAWRSVLGD 628
Cdd:PRK04863  280 ERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLE---QDYQAASDHLnlvQTALRQQEKIERYQAD 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  629 eksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELA---VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 705
Cdd:PRK04863  357 --------LEELEERLEEQNEVVEEADEQQEENEARAEAAeeeVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQ 428

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  706 ML---EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ------------EALDRADLLKTERSDL 770
Cdd:PRK04863  429 LCglpDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQlvrkiagevsrsEAWDVARELLRRLREQ 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  771 EYQLENIQVLYSHEKvKMEGTISQQTKLIDFLQAkmdqpAKKKkglFSRRKEDPALPTQVPLQYNELKLALEKEKARCAE 850
Cdd:PRK04863  509 RHLAEQLQQLRMRLS-ELEQRLRQQQRAERLLAE-----FCKR---LGKNLDDEDELEQLQEELEARLESLSESVSEARE 579

                         330       340
                  ....*....|....*....|..
gi 767972912  851 LEEALQKTRIELRSAREEAAHR 872
Cdd:PRK04863  580 RRMALRQQLEQLQARIQRLAAR 601
PRK12704 PRK12704
phosphodiesterase; Provisional
 52-210 3.82e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   52 KRSLEQARMEVSQEDDKAL----QLLHDIREQ-----SRKLQEIKEQEYQAQVEEMRLmmNQLEEDLVSARRRSDLYESE 122
Cdd:PRK12704   41 KRILEEAKKEAEAIKKEALleakEEIHKLRNEfekelRERRNELQKLEKRLLQKEENL--DRKLELLEKREEELEKKEKE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  123 LRESRlaaEEFKRKATECQHKLLKAKDqgkpevgeyaKLEKI---NAEQqlKIQELQEKLEKavKASTEATELLQNI-RQ 198
Cdd:PRK12704  119 LEQKQ---QELEKKEEELEELIEEQLQ----------ELERIsglTAEE--AKEILLEKVEE--EARHEAAVLIKEIeEE 181

                         170
                  ....*....|..
gi 767972912  199 AKERAERELEKL 210
Cdd:PRK12704  182 AKEEADKKAKEI 193
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 163-310 3.85e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 40.27  E-value: 3.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   163 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLE 242
Cdd:pfam13851   19 DITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEE---VEELRKQLENYEKDKQSLKNLKARLK 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   243 TMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhLEVHLKQKEQHY--EEKIKVLDNQIKK 310
Cdd:pfam13851   96 VLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAI-----QDVQQKTGLKNLllEKKLQALGETLEK 160
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 938-990 4.22e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 37.07  E-value: 4.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767972912  938 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 990
Cdd:cd20887     2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
mukB PRK04863
chromosome partition protein MukB;
324-737 4.39e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.87  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  324 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 399
Cdd:PRK04863  276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  400 GKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESq 479
Cdd:PRK04863  355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALER- 425

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  480 LRQAKTELEETTAEAEEEIQALTAHRDEIQrkfDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLdeasgaNDE 559
Cdd:PRK04863  426 AKQLCGLPDLTADNAEDWLEEFQAKEQEAT---EELL-------SLEQKLS-VAQAAHSQFEQAYQLVRKI------AGE 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  560 IVqlRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 636
Cdd:PRK04863  489 VS--RSEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEqrlRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR 566

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  637 VRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLNDL-EKKHAMLEMNAR--- 712
Cdd:PRK04863  567 LESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALARLrEQSGEEFEDSQDvte 631

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 767972912  713 SLQQKLETEREL----------KQRLLEEQAKLQQ 737
Cdd:PRK04863  632 YMQQLLERERELtverdelaarKQALDEEIERLSQ 666
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 938-987 4.41e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 36.88  E-value: 4.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  938 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20796     1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 562-882 4.98e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 4.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   562 QLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ---VMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVR 638
Cdd:pfam17380  300 RLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQermAMERERELERIRQEERKRELER-IRQEEIAMEISRMR 378

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   639 ELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNARSLQ-QK 717
Cdd:pfam17380  379 ELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEARQREvRR 439

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   718 LETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKVKMEGTIS 793
Cdd:pfam17380  440 LEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEERKQAMIE 510

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   794 QQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIELRSAREEA 869
Cdd:pfam17380  511 EERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMMRQIVESE 585

                          330
                   ....*....|...
gi 767972912   870 AHRKATDHPHPST 882
Cdd:pfam17380  586 KARAEYEATTPIT 598
PRK12705 PRK12705
hypothetical protein; Provisional
 158-294 4.99e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 41.23  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  158 YAKLEKINAEQQLKIQELQEKLEKAVKASTEAT--ELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PRK12705   32 AKEAERILQEAQKEAEEKLEAALLEAKELLLRErnQQRQEARREREELQREEERLVQKEEQLDARAEKLDNLENQLEERE 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972912  236 NKVK-----RLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ-VSAQHLEVHLKQKE 294
Cdd:PRK12705  112 KALSareleLEELEKQLDNELYRVAGLTPEQARKLLLKLLDAELEEEKAQrVKKIEEEADLEAER 176
pepcterm_ChnLen TIGR03007
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this ...
 563-742 5.05e-03

polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this protein family belong to the family of polysaccharide chain length determinant proteins (pfam02706). All are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria, and are found near the epsH homolog that is the putative exosortase gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274386 [Multi-domain]  Cd Length: 498  Bit Score: 41.19  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   563 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE-----EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRV 637
Cdd:TIGR03007  202 YYSEISEAQEELEAARLELNEAIAQRDALKRQLGGEEpvllaGSSVANSELDGRIEALEKQLDALRLRYTDKHPDVI-AT 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   638 RELQRMLDTEKQSRARADQRITESR-------QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmn 710
Cdd:TIGR03007  281 KREIAQLEEQKEEEGSAKNGGPERGeianpvyQQLQIELAEAEAEIASLEARVAELTARIERLESLLRTIPEVEAELT-- 358

                          170       180       190
                   ....*....|....*....|....*....|....
gi 767972912   711 arSLQQKLETERELKQRLLE--EQAKLQQQMDLQ 742
Cdd:TIGR03007  359 --QLNRDYEVNKSNYEQLLTrrESAEVSKQMEVQ 390
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 298-480 5.33e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  298 EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 377
Cdd:COG1579    23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  378 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLEHEEQKLELKRQLTELQL 457
Cdd:COG1579    88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149

                         170       180
                  ....*....|....*....|...
gi 767972912  458 SLQERESQLTALQAARAALESQL 480
Cdd:COG1579   150 ELAELEAELEELEAEREELAAKI 172
PRK11281 PRK11281
mechanosensitive channel MscK;
159-606 5.55e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  159 AKLEKIN------AEQQLKIQELQEKLE---KAVKASTEATELLQNIRQAKER---AERELEKLQNREDSSEGIR-KKL- 224
Cdd:PRK11281   43 AQLDALNkqklleAEDKLVQQDLEQTLAlldKIDRQKEETEQLKQQLAQAPAKlrqAQAELEALKDDNDEETRETlSTLs 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  225 ---VEA--EERRHSLENKVKRLETM-----------ERRENRLkDDIQTKSQQIQQMADKILELEEKHREAQVSaqhlev 288
Cdd:PRK11281  123 lrqLESrlAQTLDQLQNAQNDLAEYnsqlvslqtqpERAQAAL-YANSQRLQQIRNLLKGGKVGGKALRPSQRV------ 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  289 hLKQKEQHYeekikvLDNQI---KKDLADKETLENMMQRHEEEAHEKgkilseqkaminamdskIRSLEQRIVELSEAnk 365
Cdd:PRK11281  196 -LLQAEQAL------LNAQNdlqRKSLEGNTQLQDLLQKQRDYLTAR-----------------IQRLEHQLQLLQEA-- 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  366 laansslFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ----NRKLEEqlekishqdhsdknRLLELETRLREVSleh 441
Cdd:PRK11281  250 -------INSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeleiNLQLSQ--------------RLLKATEKLNTLT--- 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  442 eEQKLELKRQLTELQLSLQERESQLTALQA----ARAALESQ--LRQAKteleeTTAEAEEEIQALTAHRDEIQRKFDAL 515
Cdd:PRK11281  306 -QQNLRVKNWLDRLTQSERNIKEQISVLKGslllSRILYQQQqaLPSAD-----LIEGLADRIADLRLEQFEINQQRDAL 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  516 RNSCTVITDLEEqlNQLTEDNAELNNQnfyLSKQLDEASGANDEIV-QLRSEvdhLRREITereMQLTsQKQTM---EAL 591
Cdd:PRK11281  380 FQPDAYIDKLEA--GHKSEVTDEVRDA---LLQLLDERRELLDQLNkQLNNQ---LNLAIN---LQLN-QQQLLsvsDSL 447

                         490       500
                  ....*....|....*....|...
gi 767972912  592 KTTctmLEEQV--------MDLE 606
Cdd:PRK11281  448 QST---LTQQIfwvnsnkpMDLD 467
PRK12704 PRK12704
phosphodiesterase; Provisional
 670-797 5.57e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  670 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 746
Cdd:PRK12704   32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767972912  747 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 797
Cdd:PRK12704  103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
424-787 5.87e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 5.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  424 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTA 503
Cdd:COG4372    12 RLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLE-------EELEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  504 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS 583
Cdd:COG4372    85 LNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ---LEAQIAELQSEIAEREEELKELEEQLES 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  584 QKQTMEALKTTCTMLEEQVMDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 663
Cdd:COG4372   162 LQEELAALEQELQALSEAEAE-QALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  664 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 743
Cdd:COG4372   241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL-EALEEAALELKLLALLLNLAALSLIGALEDALLA 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 767972912  744 NHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 787
Cdd:COG4372   320 ALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGA 363
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 171-755 6.32e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 41.28  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   171 KIQELQeKLEKAVKASTEaTELLQNIRQakERAERELEKLQNREDS----SEGIRKKLVEAEERRHSLEN-KVKRLETME 245
Cdd:pfam07111   71 QLQELR-RLEEEVRLLRE-TSLQQKMRL--EAQAMELDALAVAEKAgqaeAEGLRAALAGAEMVRKNLEEgSQRELEEIQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   246 R-RENRLKDDIQTKSQQIQQMADKILELE------EKHR--------EAQVSAQHLEVHLKQKEQHYEEKIKVLDNqIKK 310
Cdd:pfam07111  147 RlHQEQLSSLTQAHEEALSSLTSKAEGLEkslnslETKRageakqlaEAQKEAELLRKQLSKTQEELEAQVTLVES-LRK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   311 DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQ 390
Cdd:pfam07111  226 YVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRKIQ 291

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   391 QKFYLETQAGKleaqnrkleeqleKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE--------------LQ 456
Cdd:pfam07111  292 PSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAElqeqvtsqsqeqaiLQ 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   457 LSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN 536
Cdd:pfam07111  359 RALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQ-------QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARI 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   537 AELNNQNFYLSKQLDEASG---ANDEIVQLRSEVDHLRREITEREMQLTSQkqtMEALKTTCTMLEEQV-MDLEALNDEL 612
Cdd:pfam07111  432 PSLSNRLSYAVRKVHTIKGlmaRKVALAQLRQESCPPPPPAPPVDADLSLE---LEQLREERNRLDAELqLSAHLIQQEV 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   613 LEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 692
Cdd:pfam07111  509 GRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVET 588

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972912   693 -----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQRL--LEEQAKLQQQMdlqknhifRLTQGLQE 755
Cdd:pfam07111  589 rlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQELrrLQDEARKEEGQ--------RLARRVQE 653
Caldesmon pfam02029
Caldesmon;
3-338 6.72e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.01  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     3 EQEMTRlHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYiTECSSLKRSleqarMEVSQEDDKALQLLHDIREQSRK 82
Cdd:pfam02029    4 EEEAAR-ERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY-EEDSELKPS-----GQGGLDEEEAFLDRTAKREERRQ 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    83 LQEIKEQEYQAQVEE--------MRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQ---HKLLKAKDQG 151
Cdd:pfam02029   77 KRLQEALERQKEFDPtiadekesVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENkwsTEVRQAEEEG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   152 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR----QAKERAERELEKLQNREDSSEGIRKKLVEA 227
Cdd:pfam02029  157 EEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQER 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   228 EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMAdkILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldnQ 307
Cdd:pfam02029  237 EEEAEVFLEAEQKLEELRRRRQEKESEEFEKLRQKQQEA--ELELEELKKKREERRKLLEEEEQRRKQEEAER------K 308

                          330       340       350
                   ....*....|....*....|....*....|.
gi 767972912   308 IKKDlADKETLENMMQRHEEEAHEKGKILSE 338
Cdd:pfam02029  309 LREE-EEKRRMKEEIERRRAEAAEKRQKLPE 338
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 1-251 6.82e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 40.83  E-value: 6.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     1 MMEQEMTRLHRRVSEvEAVLSQK-EVELKASETQRSLLEQDLATYITECSSLKRSLEQAR-MEVSQEDDKALQLLH---- 74
Cdd:pfam05622  187 TYKRQVQELHGKLSE-ESKKADKlEFEYKKLEEKLEALQKEKERLIIERDTLRETNEELRcAQLQQAELSQADALLspss 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    75 -------------DIREQSRKLQ--------------EIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR 127
Cdd:pfam05622  266 dpgdnlaaeimpaEIREKLIRLQhenkmlrlgqegsyRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQ 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   128 LAAEE----------FKRKATECQHKLLKAKDQGKPEVGEYAKLE-KINAEQQLKIQELQEKLEKAVkasteatellQNI 196
Cdd:pfam05622  346 KALQEqgskaedsslLKQKLEEHLEKLHEAQSELQKKKEQIEELEpKQDSNLAQKIDELQEALRKKD----------EDM 415

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972912   197 RQAKERAERELEKL----------QNREDSSE--GIRKKLVEAEERRHSLENKVKRLETMERRENRL 251
Cdd:pfam05622  416 KAMEERYKKYVEKAksviktldpkQNPASPPEiqALKNQLLEKDKKIEHLERDFEKSKLQREQEEKL 482
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 939-987 6.87e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767972912  939 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 987
Cdd:cd20807     1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
571-712 7.06e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.00  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912  571 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERqweawrsvlgdeksqfecRVRELQRMLDTEKQS 650
Cdd:COG2433   398 EREKEHEERELTEEEEEIRRLEEQVERLEAEVEELE---AELEEKDE------------------RIERLERELSEARSE 456

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912  651 RARadqRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDLeKKHAMLEMNAR 712
Cdd:COG2433   457 ERR---EIRKDREISRL-----DREIERLERELEEERERIEELKRKLERL-KELWKLEHSGE 509
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 374-581 7.17e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.50  E-value: 7.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   374 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKR 450
Cdd:pfam15619    2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   451 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 530
Cdd:pfam15619   82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767972912   531 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 581
Cdd:pfam15619  141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 95-235 8.29e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.97  E-value: 8.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   95 VEEMRLMMNQLEEDLvsarrrSDLYESeLRESRLAAEEfkrKATECQHKLLKAKDQgKPEVGEyaKLEKINAEQQLKIQE 174
Cdd:PRK00409  504 IEEAKKLIGEDKEKL------NELIAS-LEELERELEQ---KAEEAEALLKEAEKL-KEELEE--KKEKLQEEEDKLLEE 570

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972912  175 LQEKLEKAVKAST-EATELLQNIR-----QAKERAEREL-EKLQNREDSSEGIRKKLVEAEERRHSLE 235
Cdd:PRK00409  571 AEKEAQQAIKEAKkEADEIIKELRqlqkgGYASVKAHELiEARKRLNKANEKKEKKKKKQKEKQEELK 638
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 157-451 8.54e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 8.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   157 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNirQAKERAERELEKLQNREDSSEGIRKKL--VEAEERRHSL 234
Cdd:pfam13868   42 ERRLDEMMEEERERALEEEEEKEEERKEERKRYRQELEE--QIEEREQKRQEEYEEKLQEREQMDEIVerIQEEDQAEAE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   235 ENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLAD 314
Cdd:pfam13868  120 EKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQDE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   315 KETLENMMQR-----HEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnKLAANSSLFTQRNMKAQEEMISELR 389
Cdd:pfam13868  200 KAERDELRAKlyqeeQERKERQKEREEAEKKARQRQELQQAREEQIELKERRLA-EEAEREEEEFERMLRKQAEDEEIEQ 278

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972912   390 QQKfylETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREvSLEHEEQKLELKRQ 451
Cdd:pfam13868  279 EEA---EKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLRE-EEAERRERIEEERQ 336
Filament pfam00038
Intermediate filament protein;
423-740 9.11e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.29  E-value: 9.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   423 DKNRLLELETRLREVSL-EHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqa 500
Cdd:pfam00038   18 DKVRFLEQQNKLLETKIsELRQKKGAEPSRLYSLyEKEIEDLRRQLDTLTVERARLQLELDNL----------------- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   501 ltahRDEIQRkfdaLRNSctvitdLEEQLNQLTEDNAELNNqnfyLSKQLDEASGANDE----IVQLRSEVDHLRR---- 572
Cdd:pfam00038   81 ----RLAAED----FRQK------YEDELNLRTSAENDLVG----LRKDLDEATLARVDleakIESLKEELAFLKKnhee 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   573 EITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQweawrsvlgDEKSQFECRVRELQRMLDTEKQSRA 652
Cdd:pfam00038  143 EVRELQAQVSDTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNRE---------EAEEWYQSKLEELQQAAARNGDALR 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   653 RADQRITESRQVVElavkehkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE-RELKQRLLEE 731
Cdd:pfam00038  214 SAKEEITELRRTIQ-----------SLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAElQETRQEMARQ 282


                   ....*....
gi 767972912   732 QAKLQQQMD 740
Cdd:pfam00038  283 LREYQELLN 291
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1-300 9.89e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 40.66  E-value: 9.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912     1 MMEQEMTRLHRRVSEVEAVLSQKEVELKA----------------SETQRSLLEQDLATyITECSSLKRSLEQARMevsq 64
Cdd:pfam15964  389 ALRKEMKKEREELGATMLALSQNVAQLEAqvekvtreknslvsqlEEAQKQLASQEMDV-TKVCGEMRYQLNQTKM---- 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912    65 EDDKALQLLHDIREQSRKLQEIKEQEyqaqVEEMRLMMNQLEEDLVSARRRsdlyESELRESRLAAEEFKRKATECQHKL 144
Cdd:pfam15964  464 KKDEAEKEHREYRTKTGRQLEIKDQE----IEKLGLELSESKQRLEQAQQD----AARAREECLKLTELLGESEHQLHLT 535

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   145 LKAKDQGKPEVGEYAKLEKINAEQ--QLKIQELQEKLEKAVKASTEATELL--QN--IRQAKERAERELEKLQNREDSSE 218
Cdd:pfam15964  536 RLEKESIQQSFSNEAKAQALQAQQreQELTQKMQQMEAQHDKTVNEQYSLLtsQNtfIAKLKEECCTLAKKLEEITQKSR 615

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972912   219 GIRKKLveAEERRHSLEnkvkRLETMERRENRLKDDIQTKSQQIQQMADKILELEekhREAQVSAQHLEVHLKQKEQHYE 298
Cdd:pfam15964  616 SEVEQL--SQEKEYLQD----RLEKLQKRNEELEEQCVQHGRMHERMKQRLRQLD---KHCQATAQQLVQLLSKQNQLFK 686


                   ..
gi 767972912   299 EK 300
Cdd:pfam15964  687 ER 688
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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