|
Name |
Accession |
Description |
Interval |
E-value |
| CNH |
smart00036 |
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2; |
1204-1500 |
6.18e-74 |
|
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
Pssm-ID: 214481 Cd Length: 302 Bit Score: 248.80 E-value: 6.18e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1204 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHVPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1276
Cdd:smart00036 2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1277 LAQSHLPAQPDISPNiFEAVKGCHLFGAGKIENGLCICAAMPSKVVIL-RYNENLSKYCIR-----KEIETSEPCSCIHF 1350
Cdd:smart00036 82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1351 TNY---SILIGTNKfYEIDMKQYTlEEFLDKNDHSLAPAVFAASSNSFPVSIVQvnsagqREEYLLCFHEFGVFVDSYG- 1426
Cdd:smart00036 161 SSFerpGICIGSDK-GGGDVVQFH-ESLVSKEDLSLPFLSEETSLKPISVVQVP------RDEVLLCYDEFGVFVNLYGk 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972910 1427 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAylDIPNPRYLGPaiSSGAIYLASSY 1500
Cdd:smart00036 233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
|
|
| CNH |
pfam00780 |
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ... |
1212-1464 |
9.69e-68 |
|
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Pssm-ID: 459938 Cd Length: 261 Bit Score: 229.44 E-value: 9.69e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1212 SDQVVLVGTEEGLYALNV-LKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDISP 1290
Cdd:pfam00780 1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1291 NIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1368
Cdd:pfam00780 77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1369 QYTLEEFLdkndhsLAPAVFAASSNSFPVSIVQVNsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1448
Cdd:pfam00780 157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226
|
250
....*....|....*.
gi 767972910 1449 YLFVTHFNSLEVIEIQ 1464
Cdd:pfam00780 227 YLLAFHDNFIEIRDVE 242
|
|
| CRIK |
cd20814 |
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ... |
955-1010 |
3.88e-38 |
|
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410364 Cd Length: 56 Bit Score: 136.61 E-value: 3.88e-38
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 955 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1010
Cdd:cd20814 1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
85-897 |
9.85e-26 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 115.92 E-value: 9.85e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168 197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 151 EEFKRKATECQHKLLKAKdqgkpevGEYAKLEKinaeqqlKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 230
Cdd:TIGR02168 277 SELEEEIEELQKELYALA-------NEISRLEQ-------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 231 QNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKhreaqvsAQHLEVH 309
Cdd:TIGR02168 343 EEKLEELKEELESLEAElEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-------LERLEDR 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 310 LKQKEQHYEEkikvldnqikkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaan 389
Cdd:TIGR02168 416 RERLQQEIEE-------------LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA------ 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 390 sslftqrnMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKiSHQDHSDKNRLLEL-------ETRLrEVSLEHE 462
Cdd:TIGR02168 477 --------LDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKN-QSGLSGILGVLSELisvdegyEAAI-EAALGGR 546
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 463 EQKLELKRQLTELQL--SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCT 540
Cdd:TIGR02168 547 LQAVVVENLNAAKKAiaFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 541 VITDLEEQLNQLTEDNAELNnqNFYLSKQLDEASG--------ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 612
Cdd:TIGR02168 627 VVDDLDNALELAKKLRPGYR--IVTLDGDLVRPGGvitggsakTNSSILERRREIEELEEKIEELEEKIAELEKALAELR 704
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 613 TTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLgdekSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkeh 692
Cdd:TIGR02168 705 KELEELEEE---LEQLRKELEELSRQISALRKDL----ARLEAEVEQLEERIAQLSKELTELEAEIEELEE--------- 768
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 693 kaEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQG 772
Cdd:TIGR02168 769 --RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 773 LQEALDRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 849
Cdd:TIGR02168 847 IEELSEDIESLAAEIEELEELIEELEselEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 850 VPLQYNELKLALEKEKARCAE---LEEALQKTRIELRSAREEAAHRKATDH 897
Cdd:TIGR02168 927 LELRLEGLEVRIDNLQERLSEeysLTLEEAEALENKIEDDEEEARRRLKRL 977
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
13-790 |
3.37e-25 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 114.38 E-value: 3.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 13 QDSQDKCHKMEQEMTRLHRRVSEVEAVL----SQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqedDK 88
Cdd:TIGR02168 175 KETERKLERTRENLDRLEDILNELERQLksleRQAEKAERYKELKAELRELELALLVLRLEELREELEELQEEL----KE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 89 ALQLLHDIREQSrklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRR--------SDLyESELRE--SRLAAEEFKRKAT 158
Cdd:TIGR02168 251 AEEELEELTAEL--------QELEEKLEELRLEVSELEEEIEELQKElyalaneiSRL-EQQKQIlrERLANLERQLEEL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 159 ECQHKLLKAKDQGKPEvgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSse 238
Cdd:TIGR02168 322 EAQLEELESKLDELAE--ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS-- 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 239 gIRKKLVEAEERRHSLENKVKRL-----ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQK 313
Cdd:TIGR02168 398 -LNNEIERLEARLERLEDRRERLqqeieELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA 476
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 314 EQHYEEKIKVLDNQIkkdladkETLENMMQRHEEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANS 390
Cdd:TIGR02168 477 LDAAERELAQLQARL-------DSLERLQENLEGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRL 547
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 391 SLFTQRNMKAQEEMISELRQQK-----FYLETQAGKLEAQNRKLEE------------QLEKISHQDHSDKNRLL----- 448
Cdd:TIGR02168 548 QAVVVENLNAAKKAIAFLKQNElgrvtFLPLDSIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlv 627
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 449 ------------ELETRLREVSLE-------------HEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQL 500
Cdd:TIGR02168 628 vddldnalelakKLRPGYRIVTLDgdlvrpggvitggSAKTNssiLERRREIEELEEKIEELEEKIAELEKALAELRKEL 707
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 501 RQAKTELEETTAEAEEEIQALTAHRDEIQRkfdalrnsctvitdLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEI 580
Cdd:TIGR02168 708 EELEEELEQLRKELEELSRQISALRKDLAR--------------LEAEVEQLEERIAQLSKE---LTELEAEIEELEERL 770
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 581 VQLRSEVDHLRREITEREMQLtsqKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVREL 660
Cdd:TIGR02168 771 EEAEEELAEAEAEIEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 661 QRM-LDTEKQSRARADQRITESRQvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 739
Cdd:TIGR02168 848 EELsEDIESLAAEIEELEELIEEL--ESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLA 925
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 740 TER----ELKQRLLEEQAKL--QQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDL 790
Cdd:TIGR02168 926 QLElrleGLEVRIDNLQERLseEYSLTLEeaEALENKIEDDEEEARRRLKRLENKIKEL 984
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
25-798 |
5.85e-23 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 107.06 E-value: 5.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 25 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVsqeddkaLQLLHDIREQSRKLQ 104
Cdd:TIGR02168 233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL-------YALANEISRLEQQKQ 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 105 EIKEQEYQAQVEEMRLmmnqlEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLlkakdqgkpevgeyAKLEKI 184
Cdd:TIGR02168 306 ILRERLANLERQLEEL-----EAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL--------------EELEAE 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 185 NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ----NREDSSEGIRKKLVEAE---------ERR 251
Cdd:TIGR02168 367 LEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEdrreRLQQEIEELLKKLEEAElkelqaeleELE 446
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 252 HSLENKVKRLETMERRENRLKDDIQTKSQQIQQmadkileLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 331
Cdd:TIGR02168 447 EELEELQEELERLEEALEELREELEEAEQALDA-------AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLS 519
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 332 -----LADKETLENMMQRHEEEAHEK--GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 404
Cdd:TIGR02168 520 gilgvLSELISVDEGYEAAIEAALGGrlQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEG 599
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 405 ISELRQQKFYLETQAGKL---------------EAQN--RKLEEQLEKISHQDHSDKNR-LLELETRLREVSLEHEEQKL 466
Cdd:TIGR02168 600 FLGVAKDLVKFDPKLRKAlsyllggvlvvddldNALElaKKLRPGYRIVTLDGDLVRPGgVITGGSAKTNSSILERRREI 679
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 467 -ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDL 545
Cdd:TIGR02168 680 eELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 546 EEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 625
Cdd:TIGR02168 760 EAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 626 EALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR---QVVELAVKEHKAEILALQQA 702
Cdd:TIGR02168 837 ERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRselEELSEELRELESKRSELRRE 916
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 703 LKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ----KNHIFRLTQGLQE--- 775
Cdd:TIGR02168 917 LEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDDeeeaRRRLKRLENKIKElgp 986
|
810 820 830
....*....|....*....|....*....|....
gi 767972910 776 ----ALD-------RADLLKTERSDLEYQLENIQ 798
Cdd:TIGR02168 987 vnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
186-797 |
1.08e-22 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 105.79 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 186 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEerrhslenkvKRLETME 265
Cdd:COG1196 209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE----------AELEELR 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 266 RRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRH 345
Cdd:COG1196 274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELE----ERLEELEEELAELEEELEELEEELEELEEELEEA 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 346 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ 425
Cdd:COG1196 350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 426 NRKLEEQLEKISHQDHSDKNRLLELETR---LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQ 502
Cdd:COG1196 430 LAELEEEEEEEEEALEEAAEEEAELEEEeeaLLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEG 509
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 503 AKTELEETTAEAEeeIQALTAHRDEIQRKFDALRnsctviTDLEEQLNQLTEDNAElnnqnfylskqldeasGANDEIVQ 582
Cdd:COG1196 510 VKAALLLAGLRGL--AGAVAVLIGVEAAYEAALE------AALAAALQNIVVEDDE----------------VAAAAIEY 565
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 583 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQR 662
Cdd:COG1196 566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR 645
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 663 MLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 742
Cdd:COG1196 646 LREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEA 725
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 743 ElKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI 797
Cdd:COG1196 726 L-EEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
249-809 |
8.37e-22 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 103.09 E-value: 8.37e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 249 ERRHSLENKvkrLETMERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 320
Cdd:COG1196 172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 321 IKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 400
Cdd:COG1196 248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 401 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVS----------LEHEEQKLELKR 470
Cdd:COG1196 321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 471 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 550
Cdd:COG1196 401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 551 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQ---------K 605
Cdd:COG1196 481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNivveddevaA 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 606 QTMEALKTT----CTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 681
Cdd:COG1196 561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 682 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 761
Cdd:COG1196 641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 767972910 762 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 809
Cdd:COG1196 721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
10-740 |
1.76e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 102.06 E-value: 1.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKA 89
Cdd:TIGR02168 239 EELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQL 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 90 LQLLHDIREQSRKLQEIKE---------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEC 160
Cdd:TIGR02168 319 EELEAQLEELESKLDELAEelaeleeklEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 161 QHKLLKAKDQGKPEVGEYAKLEKINAEQQ-----LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED 235
Cdd:TIGR02168 399 NNEIERLEARLERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALD 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 236 SSegiRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKIlELEEKHREA-----QVSAQHLEV-- 308
Cdd:TIGR02168 479 AA---ERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELI-SVDEGYEAAieaalGGRLQAVVVen 554
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 309 ---------HLKQKE----------QHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 369
Cdd:TIGR02168 555 lnaakkaiaFLKQNElgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNA 634
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 370 IRSL-----EQRIVEL-----------SEANKLAANSSLFTQRN-------MKAQEEMISELRQQKFYLETQAGKLEAQN 426
Cdd:TIGR02168 635 LELAkklrpGYRIVTLdgdlvrpggviTGGSAKTNSSILERRREieeleekIEELEEKIAELEKALAELRKELEELEEEL 714
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 427 RKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQA 503
Cdd:TIGR02168 715 EQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQL 794
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 504 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasga 576
Cdd:TIGR02168 795 KEELKALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDIESLAAEIEELEELIEE---- 870
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 577 ndeivqLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 656
Cdd:TIGR02168 871 ------LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER 944
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 657 VRELQRML--------DTEKQSRARADQRITESRQ------VVELAVKEHKAEILALQQALKEQKlkaESLSDKLNDLEK 722
Cdd:TIGR02168 945 LSEEYSLTleeaealeNKIEDDEEEARRRLKRLENkikelgPVNLAAIEEYEELKERYDFLTAQK---EDLTEAKETLEE 1021
|
810
....*....|....*...
gi 767972910 723 khAMLEMNARSLQQKLET 740
Cdd:TIGR02168 1022 --AIEEIDREARERFKDT 1037
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
144-791 |
2.64e-21 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 101.55 E-value: 2.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 144 RESRLAAE--EFKRKATECQHKLLKAKDQGKpevgeYAKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKE 221
Cdd:COG1196 207 RQAEKAERyrELKEELKELEAELLLLKLREL-----EAELEELEAE----LEELEAELEELEAELAELEAELEELRLELE 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 222 RAERELEKLQNREdssEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQV 301
Cdd:COG1196 278 ELELELEEAQAEE---YELLAELARLEQDIARLEERRREL---EERLEELEEELAELEEELEELEEELEELEEELEEAEE 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 302 SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAhekgkilseqkaminamdSKIRSLEQRIvels 381
Cdd:COG1196 352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA------------------AQLEELEEAE---- 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 382 eanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEH 461
Cdd:COG1196 410 -------------EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE--------AELEEEEEALLELLAEL 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 462 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctv 541
Cdd:COG1196 469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA--- 543
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 542 itDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM-- 617
Cdd:COG1196 544 --LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGdt 621
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 618 LEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEIL 697
Cdd:COG1196 622 LLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALL 700
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 698 ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-- 775
Cdd:COG1196 701 AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAlg 780
|
650 660
....*....|....*....|....*...
gi 767972910 776 -----ALD-------RADLLKTERSDLE 791
Cdd:COG1196 781 pvnllAIEeyeeleeRYDFLSEQREDLE 808
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1-750 |
6.61e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 100.52 E-value: 6.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAtyitecsslkrsLEQARM 80
Cdd:TIGR02168 279 LEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELA------------ELEEKL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 81 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEC 160
Cdd:TIGR02168 347 EELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEEL 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 161 QHKLLKAkdQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGI 240
Cdd:TIGR02168 427 LKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 241 RKKLVEAEERRHSLENKVKRL----ETMERRENRLKDDIQTKSQQI----QQMADKILELEEKHREAQV--------SAQ 304
Cdd:TIGR02168 505 SEGVKALLKNQSGLSGILGVLseliSVDEGYEAAIEAALGGRLQAVvvenLNAAKKAIAFLKQNELGRVtflpldsiKGT 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 305 HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMM--------------QRHEEEAHE-----KGKILSEQKAMINA 365
Cdd:TIGR02168 585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvvddldnaleLAKKLRPGYrivtlDGDLVRPGGVITGG 664
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 366 MDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN 445
Cdd:TIGR02168 665 SAKTNSSILERRREIEELEE-----------KIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 446 RLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALT 522
Cdd:TIGR02168 734 DLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELT 813
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 523 AHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLT 602
Cdd:TIGR02168 814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----------EDIESLAAEIEELEELIEELESELEALLNERA 883
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 603 SQKQTMEALKTTctmLEEQVMDLEALNDELLEKERQWEAwrsvLGDEKSQFECRVRELQRMLDtEKQSRARADQRITEsr 682
Cdd:TIGR02168 884 SLEEALALLRSE---LEELSEELRELESKRSELRRELEE----LREKLAQLELRLEGLEVRID-NLQERLSEEYSLTL-- 953
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 683 QVVELAVKEHKAEILALQQALK--EQKLKA------------ESLSDKLNDLEKKHAMLEMNARSLQQKL-ETERELKQR 747
Cdd:TIGR02168 954 EEAEALENKIEDDEEEARRRLKrlENKIKElgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIeEIDREARER 1033
|
...
gi 767972910 748 LLE 750
Cdd:TIGR02168 1034 FKD 1036
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
187-890 |
8.67e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 100.13 E-value: 8.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 187 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLQNREDSSEG--IRKKLVEAEERRHSLENKVKRletM 264
Cdd:TIGR02168 176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 265 ERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 341
Cdd:TIGR02168 252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 342 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 421
Cdd:TIGR02168 332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 422 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 501
Cdd:TIGR02168 398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 502 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 581
Cdd:TIGR02168 472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 582 QLRSEV---------DHLRREITERemqLTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSV 645
Cdd:TIGR02168 530 SVDEGYeaaieaalgGRLQAVVVEN---LNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKD 606
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 646 LGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQK 707
Cdd:TIGR02168 607 LVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEELE 683
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 708 LKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 787
Cdd:TIGR02168 684 EKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 788 SDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 867
Cdd:TIGR02168 757 TELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832
|
730 740
....*....|....*....|...
gi 767972910 868 CAELEEALQKTRIELRSAREEAA 890
Cdd:TIGR02168 833 IAATERRLEDLEEQIEELSEDIE 855
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
217-795 |
2.83e-20 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 98.09 E-value: 2.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 217 RQAkERAER--ELEKlqnredssegiRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEE 294
Cdd:COG1196 207 RQA-EKAERyrELKE-----------ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 295 KHREAQVSAQhlevHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE 374
Cdd:COG1196 275 ELEELELELE----EAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 375 QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishQDHSDKNRLLELETRL 454
Cdd:COG1196 351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE----ALLERLERLEEELEEL 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 455 REVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAhrDEIQRKFDA 534
Cdd:COG1196 427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL--LLEAEADYE 504
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 535 LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD------HLRREITEREMQLTSQKqtM 608
Cdd:COG1196 505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVaaaaieYLKAAKAGRATFLPLDK--I 582
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 609 EALKTTCTMLEEQVMDLEALndeLLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 688
Cdd:COG1196 583 RARAALAAALARGAIGAAVD---LVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 689 VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFR 768
Cdd:COG1196 660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739
|
570 580
....*....|....*....|....*..
gi 767972910 769 LTQGLQEALDRADLLKTERSDLEYQLE 795
Cdd:COG1196 740 ELLEEEELLEEEALEELPEPPDLEELE 766
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
35-894 |
1.14e-19 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 96.19 E-value: 1.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 35 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 114
Cdd:pfam02463 143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 115 VEEMRLMMNQLEEDLVSARRRSDLYESELRES----RLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 190
Cdd:pfam02463 211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLqellRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 191 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENR 270
Cdd:pfam02463 291 LAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 271 LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAH 350
Cdd:pfam02463 371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEK 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 351 EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkLEAQNRKLE 430
Cdd:pfam02463 451 EELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS--------------GLKVLLALI 516
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 431 EQLEKISHQDHSDKNRLLE--LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 508
Cdd:pfam02463 517 KDGVGGRIISAHGRLGDLGvaVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAV 596
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 509 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 588
Cdd:pfam02463 597 LEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELL 676
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 589 HLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 667
Cdd:pfam02463 677 EIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSR 756
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 668 KQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQR 747
Cdd:pfam02463 757 LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEEL 835
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 748 LLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 827
Cdd:pfam02463 836 EELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLN 910
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 828 QPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 894
Cdd:pfam02463 911 LLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNL 977
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
70-722 |
2.69e-19 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 95.00 E-value: 2.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 70 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 149
Cdd:COG1196 204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 150 AEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK 229
Cdd:COG1196 276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 230 LQNREDSSEGIRKKLVEA-EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEV 308
Cdd:COG1196 356 AEAELAEAEEALLEAEAElAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 309 HLKQKEQHYEEKIKvldnQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAA 388
Cdd:COG1196 436 EEEEEEEALEEAAE----EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK 511
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 389 NSSLFTQRNMKAQEemISELRQQKFYLETQAGKLEAQNRkleeqlekishqdhsdKNRLLELETRLREVSlehEEQKLEL 468
Cdd:COG1196 512 AALLLAGLRGLAGA--VAVLIGVEAAYEAALEAALAAAL----------------QNIVVEDDEVAAAAI---EYLKAAK 570
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 469 KRQLTELQLSLQERESQLTALQAARAALESQLRQAkTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQ 548
Cdd:COG1196 571 AGRATFLPLDKIRARAALAAALARGAIGAAVDLVA-SDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREV 649
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 549 LNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEAL 628
Cdd:COG1196 650 TLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQ 729
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 629 NDELLEKERQWEawrsvLGDEKSQFECRVRELQRMLDTEKQSR--ARADQRITESRQVVELAVKEHkaeilalqQALKEQ 706
Cdd:COG1196 730 LEAEREELLEEL-----LEEEELLEEEALEELPEPPDLEELERelERLEREIEALGPVNLLAIEEY--------EELEER 796
|
650
....*....|....*.
gi 767972910 707 KlkaESLSDKLNDLEK 722
Cdd:COG1196 797 Y---DFLSEQREDLEE 809
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
4-593 |
3.49e-19 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 94.62 E-value: 3.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:COG1196 233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 84 QEDDKALQLLHDIREQSRKLQEIKEQ---------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 154
Cdd:COG1196 313 ELEERLEELEEELAELEEELEELEEEleeleeeleEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 155 RKATECQHKLLKAKDQgkpEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 234
Cdd:COG1196 393 RAAAELAAQLEELEEA---EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 235 DSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQ---MADKILELEEKHREAQVSAQHLEVHLK 311
Cdd:COG1196 470 EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVAVLIGVEAAYEAALEAALAAALQ 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 312 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---QRIVELSEANKLAA 388
Cdd:COG1196 550 NIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADaryYVLGDTLLGRTLVA 629
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 389 NSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEQKLEL 468
Cdd:COG1196 630 ARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EELAERLAEEELELEEALLAEEEE 705
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 469 KRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctvITDLEEQ 548
Cdd:COG1196 706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE----------LERLERE 775
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 549 LNQL-------TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 593
Cdd:COG1196 776 IEALgpvnllaIEEYEELEERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
213-798 |
4.65e-19 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 93.93 E-value: 4.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 213 LQNIRQAKERAERELEK--------LQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQ 284
Cdd:TIGR04523 24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 285 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KETLENMMQRHEE 347
Cdd:TIGR04523 101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 348 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 422
Cdd:TIGR04523 181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 423 EAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 487
Cdd:TIGR04523 259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 488 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 565
Cdd:TIGR04523 339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 566 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV----MDLEALNDELLEKERQW 639
Cdd:TIGR04523 419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKEL 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 640 EAwrsvLGDEKSQFECRVRELqrmldTEKQSraradqritesrqvvELAVKEHKAEILALQqalKEQKLKaeSLSDKLN- 718
Cdd:TIGR04523 499 KK----LNEEKKELEEKVKDL-----TKKIS---------------SLKEKIEKLESEKKE---KESKIS--DLEDELNk 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 719 -DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL-------DRADLLKTERSDL 790
Cdd:TIGR04523 550 dDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkissleKELEKAKKENEKL 629
|
....*...
gi 767972910 791 EYQLENIQ 798
Cdd:TIGR04523 630 SSIIKNIK 637
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
2-834 |
1.16e-18 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 93.11 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463 243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQEDDKALQLLHDI--REQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATE 159
Cdd:pfam02463 323 KKKAEKELKKEKEEIeeLEKELKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 160 CQHKLLKAkdqgkpevgeyAKLEKINAEQQLKI-QELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredsse 238
Cdd:pfam02463 399 LKSEEEKE-----------AQLLLELARQLEDLlKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL------ 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 239 girKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQiqqmadkilelEEKHREAqvsaqhLEVHLKQKEQHYE 318
Cdd:pfam02463 462 ---KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQK-----------ESKARSG------LKVLLALIKDGVG 521
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 319 EKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNM 398
Cdd:pfam02463 522 GRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDP 601
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 399 KAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLS 478
Cdd:pfam02463 602 ILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQEL 681
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 479 LQERESQLtalqaarAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 558
Cdd:pfam02463 682 QEKAESEL-------AKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEK 754
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 559 LNNQNFYLSKQLDEasgandeiVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQ 638
Cdd:pfam02463 755 SRLKKEEKEEEKSE--------LSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQ 826
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 639 WEAWRSVLGDEKSQfECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 718
Cdd:pfam02463 827 EEKIKEEELEELAL-ELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEE 905
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 719 DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQ 798
Cdd:pfam02463 906 SQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEE 985
|
810 820 830
....*....|....*....|....*....|....*.
gi 767972910 799 VLYSHEKVKMEGTISQQTKlIDFLQAKMDQPAKKKK 834
Cdd:pfam02463 986 KEERYNKDELEKERLEEEK-KKLIRAIIEETCQRLK 1020
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
46-798 |
2.17e-18 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 92.05 E-value: 2.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 46 ELKASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRlmmnQL 125
Cdd:TIGR02169 231 EKEALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIG----EL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 126 EEDLVSARRRSDLYESELREsrlaAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAEqqlkIQELQEKLEKAVK 204
Cdd:TIGR02169 300 EAEIASLERSIAEKERELED----AEERLAKLEAEIDKLLAEIEELEREIEEERKrRDKLTEE----YAELKEELEDLRA 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 205 ASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS----LENKVKRLET----MERRENRLKDDIQ 276
Cdd:TIGR02169 372 ELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEeladLNAAIAGIEAkineLEEEKEDKALEIK 451
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 277 TKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK-----------------IKVLDNQIKK--------- 330
Cdd:TIGR02169 452 KQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAeaqaraseervrggravEEVLKASIQGvhgtvaqlg 531
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 331 ----------DLADKETLENMMQRHEEEAHEKGKILSEQKAM------INAMDSKIRSLE--------QRIVELSEANKL 386
Cdd:TIGR02169 532 svgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratflpLNKMRDERRDLSilsedgviGFAVDLVEFDPK 611
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 387 AANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeqLEKI-SHQDHSDKNRLLELETR-LREVSLEHEE 463
Cdd:TIGR02169 612 YEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL----------FEKSgAMTGGSRAPRGGILFSRsEPAELQRLRE 681
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 464 QKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVIT 543
Cdd:TIGR02169 682 RLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELK 761
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 544 DLEEQLNQLTEDNAELNNQNFYLskqldEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 623
Cdd:TIGR02169 762 ELEARIEELEEDLHKLEEALNDL-----EARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQ 836
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 624 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ---RMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQ 700
Cdd:TIGR02169 837 ELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKR 916
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 701 QALKEQKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDLQknhiFRLTQGLQEALDRA 780
Cdd:TIGR02169 917 KRLSELKAKLEALEEELSEIEDPKGEDE----EIPEEELSLEDVQAELQRVEEEIRALEPVN----MLAIQEYEEVLKRL 988
|
810
....*....|....*...
gi 767972910 781 DLLKTERSDLEYQLENIQ 798
Cdd:TIGR02169 989 DELKEKRAKLEEERKAIL 1006
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
25-791 |
2.87e-18 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 92.13 E-value: 2.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 25 EMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdlatyitecsslKRSLEQARMEVSQEDDKALQLLHDIR--EQSRK 102
Cdd:PTZ00121 1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEE------------AKKTETGKAEEARKAEEAKKKAEDARkaEEARK 1135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 103 LQEIKEQEYQAQVEEMRlmmnqleeDLVSARRRSDLYESElrESRLAAE----EFKRKATECQ--HKLLKAKDQGKPEVG 176
Cdd:PTZ00121 1136 AEDARKAEEARKAEDAK--------RVEIARKAEDARKAE--EARKAEDakkaEAARKAEEVRkaEELRKAEDARKAEAA 1205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 177 EYAKLEKiNAEQQLKIQElqEKLEKAVKASTEATELLQNIRQA-KERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 255
Cdd:PTZ00121 1206 RKAEEER-KAEEARKAED--AKKAEAVKKAEEAKKDAEEAKKAeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 256 nkVKRLETMERRENRLKDDIQTKSQQIQQMAD---KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKiKVLDNQIKKDL 332
Cdd:PTZ00121 1283 --LKKAEEKKKADEAKKAEEKKKADEAKKKAEeakKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEA 1359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 333 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK 412
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 413 FYLETQAGKLEA---QNRKLEEQLEKISHQDHSD--------KNRLLELETRLREVSLEHEE--QKLELKRQLTELQLSL 479
Cdd:PTZ00121 1440 AEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADeakkkaeeAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAE 1519
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 480 QERES-QLTALQAARAALE----SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitdleEQLNQLTE 554
Cdd:PTZ00121 1520 EAKKAdEAKKAEEAKKADEakkaEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA--------EEAKKAEE 1591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 555 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdHLRREITEREMQLTSQKQTMEALKTTCTML---EEQVMDLEALNDE 631
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE--ELKKAEEEKKKVEQLKKKEAEEKKKAEELKkaeEENKIKAAEEAKK 1669
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 632 LLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEkQSRARADQRITESRQVVElAVKEHKAEILALQQALKEQKLKAE 711
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAE 1747
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 712 SLsdKLNDLEKK---HAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS 788
Cdd:PTZ00121 1748 EA--KKDEEEKKkiaHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825
|
...
gi 767972910 789 DLE 791
Cdd:PTZ00121 1826 EME 1828
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
23-456 |
7.47e-18 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 90.50 E-value: 7.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 23 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 102
Cdd:TIGR02168 676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 103 LQEIKEQEyqaqveemrlmmnqleedlvsarrrsDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLE 182
Cdd:TIGR02168 756 LTELEAEI--------------------------EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 183 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ-NREDSSEGIRKKLVEAEErrhslenKVKRL 261
Cdd:TIGR02168 810 AELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAaEIEELEELIEELESELEA-------LLNER 882
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 262 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLkqkeqhyeEKIKVLDNQIKKDLADKETLENM 341
Cdd:TIGR02168 883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL--------EGLEVRIDNLQERLSEEYSLTLE 954
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 342 MQrheeEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEANKLAansslftqrnmkaqEEMISELRQQKFYLETQAGK 421
Cdd:TIGR02168 955 EA----EALENKIEDDEEEA-----RRRLKRLENKIKELGPVNLAA--------------IEEYEELKERYDFLTAQKED 1011
|
410 420 430
....*....|....*....|....*....|....*
gi 767972910 422 LEAQNRKLEEQLEKIshqDHSDKNRLLELETRLRE 456
Cdd:TIGR02168 1012 LTEAKETLEEAIEEI---DREARERFKDTFDQVNE 1043
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
234-891 |
4.93e-17 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 87.80 E-value: 4.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 EDSSEGIRKKLVEA------EERRHSLENKvkrLETMERRENRLKDDI-----QTKSQQIQ-QMADKILELEEKHREAQ- 300
Cdd:TIGR02168 151 EAKPEERRAIFEEAagiskyKERRKETERK---LERTRENLDRLEDILnelerQLKSLERQaEKAERYKELKAELRELEl 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 301 -VSAQHLEVHLKQKEQ------HYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSL 373
Cdd:TIGR02168 228 aLLVLRLEELREELEElqeelkEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 374 EQRIVELseanklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 453
Cdd:TIGR02168 308 RERLANL--------------ERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESR 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 454 LREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALT 522
Cdd:TIGR02168 374 LEELEEQLETLRskvAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEEllkkleeaELKELQAELEELEEELEELQ 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 523 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE-------VDHLRREIT 595
Cdd:TIGR02168 454 EELERLEEALEELREE---LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNqsglsgiLGVLSELIS 530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 596 ERE-------------MQ------LTSQKQTMEALK----TTCTMLEEQVM---DLEALNDELLEKERQWEAWRSVLGDE 649
Cdd:TIGR02168 531 VDEgyeaaieaalggrLQavvvenLNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKDLVKF 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 650 KSQFE---------CRV-------RELQRMLD------TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQK 707
Cdd:TIGR02168 611 DPKLRkalsyllggVLVvddldnaLELAKKLRpgyrivTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELE 690
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 708 LKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRA 780
Cdd:TIGR02168 691 EKIAELEKALAELRKELEELEEELEQLRKELEElsrqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERL 770
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 781 DLLKTERSDLEYQLENIQVLYShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLA 860
Cdd:TIGR02168 771 EEAEEELAEAEAEIEELEAQIE----QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846
|
730 740 750
....*....|....*....|....*....|.
gi 767972910 861 LEKEKARCAELEEALQKTRIELRSAREEAAH 891
Cdd:TIGR02168 847 IEELSEDIESLAAEIEELEELIEELESELEA 877
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
2-641 |
6.13e-17 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 87.04 E-value: 6.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKElqDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEqdlatyitecsSLKRSLEQARME 81
Cdd:PRK03918 180 RLEKFIKRTE--NIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELE-----------ELKEEIEELEKE 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQeddkalqllhdiREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvSARRRSDLYESELRESRLaaEEFKRKATECQ 161
Cdd:PRK03918 247 LES------------LEGSKRKLEEKIRELEERIEELKKEIEELEE---KVKELKELKEKAEEYIKL--SEFYEEYLDEL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 162 HKLLKakdqgkpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAErELEKLQNREDSSEGIR 241
Cdd:PRK03918 310 REIEK----------RLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLK 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 242 KKL--VEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEvhlkqkEQHYEE 319
Cdd:PRK03918 379 KRLtgLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELT------EEHRKE 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 320 KIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMInamdsKIRSLEQRIVELSEANKlaansslftQRNMK 399
Cdd:PRK03918 453 LLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELI-----KLKELAEQLKELEEKLK---------KYNLE 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 400 AQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQdhsdKNRLLELETRLREVslehEEQKLELKRQLTELQL-S 478
Cdd:PRK03918 519 ELEKKAEEYEK----LKEKLIKLKGEIKSLKKELEKLEEL----KKKLAELEKKLDEL----EEELAELLKELEELGFeS 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 479 LQERESQLTALQAA-RAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDNA 557
Cdd:PRK03918 587 VEELEERLKELEPFyNEYLE--LKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE-------ELRKELEELEKKYS 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 558 ElnnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN------DE 631
Cdd:PRK03918 658 E------------EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEkalervEE 725
|
650
....*....|
gi 767972910 632 LLEKERQWEA 641
Cdd:PRK03918 726 LREKVKKYKA 735
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2-745 |
9.73e-17 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 86.66 E-value: 9.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEavlsqKEVELKASETQRSLLEQdLATYITECSSLKRSLEQARME 81
Cdd:TIGR02169 243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN-----KKIKDLGEEEQLRVKEK-IGELEAEIASLERSIAEKERE 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQ 161
Cdd:TIGR02169 317 LEDAEERLAKLEAEIDKLLAEIEELERE-----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYR 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 162 HKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKL----EKAVKASTEATELLQNIRQAKERAERELEKLQNREDSS 237
Cdd:TIGR02169 392 EKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIagieAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQEL 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 238 EGIRKKLVEAEERRHSLENKVKRLETMER------RENR-----LKDDIQTKSQQIQQMadkiLELEEKHREAQVSA--Q 304
Cdd:TIGR02169 472 YDLKEEYDRVEKELSKLQRELAEAEAQARaseervRGGRaveevLKASIQGVHGTVAQL----GSVGERYATAIEVAagN 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 305 HLEVHLKQKEQHYEEKIKVLdnqiKKDLADKET---LENM--MQRHEEEAHEKGKI-----LSE-----QKA-------- 361
Cdd:TIGR02169 548 RLNNVVVEDDAVAKEAIELL----KRRKAGRATflpLNKMrdERRDLSILSEDGVIgfavdLVEfdpkyEPAfkyvfgdt 623
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 362 -MINAMDS------KIR--SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyletqaGKLEAQNRKLEEQ 432
Cdd:TIGR02169 624 lVVEDIEAarrlmgKYRmvTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERL-------EGLKRELSSLQSE 696
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 433 LEKISHQDHSDKNRLLELETRLREVSLEHE--EQKLE-LKRQLTELQLSLQERESQLTALQAARAALESQLrQAKTELEE 509
Cdd:TIGR02169 697 LRRIENRLDELSQELSDASRKIGEIEKEIEqlEQEEEkLKERLEELEEDLSSLEQEIENVKSELKELEARI-EELEEDLH 775
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 510 TTAEAEEEIQALTAHR--DEIQRKFDALRnscTVITDLEEQLNQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEV 587
Cdd:TIGR02169 776 KLEEALNDLEARLSHSriPEIQAELSKLE---EEVSRIEARLREI---EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI 849
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 588 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTE 667
Cdd:TIGR02169 850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEAL 929
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 668 KQSRARADQRITESRQVVELA-----VKEHKAEILALQQALKEQKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKL 738
Cdd:TIGR02169 930 EEELSEIEDPKGEDEEIPEEElsledVQAELQRVEEEIRALEPVNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERI 1009
|
....*..
gi 767972910 739 ETERELK 745
Cdd:TIGR02169 1010 EEYEKKK 1016
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
248-1038 |
6.31e-16 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 84.01 E-value: 6.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 248 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSQQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 320
Cdd:pfam15921 81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 321 IKVLDNQIKKDLADK-ETLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 373
Cdd:pfam15921 157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 374 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN--- 445
Cdd:pfam15921 237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 446 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 524
Cdd:pfam15921 317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 525 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 586
Cdd:pfam15921 397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 587 VDHLRREITEremqLTSQKQTMEALKTTctmleeqVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 666
Cdd:pfam15921 474 KEMLRKVVEE----LTAKKMTLESSERT-------VSDLTA---SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNE 539
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 667 EKQSR-------------ARADQRITESRQVVEL-------------AVKEHKA----EILALQQALKEQKLKAESLSDK 716
Cdd:pfam15921 540 GDHLRnvqtecealklqmAEKDKVIEILRQQIENmtqlvgqhgrtagAMQVEKAqlekEINDRRLELQEFKILKDKKDAK 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 717 LNDLEKKHAMLEMNARSL----QQKLETERELKQrlleEQAKLQQQMDLQKNHIFRLTQGLqEALDR-----ADLLKTER 787
Cdd:pfam15921 620 IRELEARVSDLELEKVKLvnagSERLRAVKDIKQ----ERDQLLNEVKTSRNELNSLSEDY-EVLKRnfrnkSEEMETTT 694
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 788 SDLEYQLENIQ--------VLYSHE---------KVKMEGTISQQTKLIDFLQAKMD------QPAKKKKGLFSRRK--- 841
Cdd:pfam15921 695 NKLKMQLKSAQseleqtrnTLKSMEgsdghamkvAMGMQKQITAKRGQIDALQSKIQfleeamTNANKEKHFLKEEKnkl 774
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 842 --EDPALPTQVPLQYNELKLALEKE---KARCAELEEALQKT------------RIELRSAREEAAHR---KATDHP-HP 900
Cdd:pfam15921 775 sqELSTVATEKNKMAGELEVLRSQErrlKEKVANMEVALDKAslqfaecqdiiqRQEQESVRLKLQHTldvKELQGPgYT 854
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 901 STPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKERMHHnIPHRFNVGLNMRATKCAVCLDTV 979
Cdd:pfam15921 855 SNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQLLQE-LRSVINEEPTVQLSKAEDKGRAP 933
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 980 HFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYAThFTEAFCRDKMNSPGLQTKEPSS 1038
Cdd:pfam15921 934 SLGALDDRVRDCIIESSLRSDICHSSSNSLQTEGSK-SSETCSREPVLLHAGELEDPSS 991
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
127-640 |
2.61e-15 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 81.65 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 127 EDLVSARRRSDLYESELRESRLAAEEFKrKATECQHKLLKAKDQGKPEVgeyakLEKINaEQQLKIQELQEKLEKAVKAS 206
Cdd:PRK03918 158 DDYENAYKNLGEVIKEIKRRIERLEKFI-KRTENIEELIKEKEKELEEV-----LREIN-EISSELPELREELEKLEKEV 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 207 TEATELLQNIRQAKERAEREL-------EKLQNREDSSEGIRKKLVEAEERR---HSLENKVKRLETMER-------REN 269
Cdd:PRK03918 231 KELEELKEEIEELEKELESLEgskrkleEKIRELEERIEELKKEIEELEEKVkelKELKEKAEEYIKLSEfyeeyldELR 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 270 RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE------VHLKQKEQHYEEKIKVLDN--QIKKDLADK--ETLE 339
Cdd:PRK03918 311 EIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKelekrlEELEERHELYEEAKAKKEEleRLKKRLTGLtpEKLE 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 340 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISELRQQKFY 414
Cdd:PRK03918 391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKRIEKELKE 470
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 415 LETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLSLQERESQ 485
Cdd:PRK03918 471 IEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKSLKKELEK 550
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 486 LTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEEQLNQLTE 554
Cdd:PRK03918 551 LEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEKELKKLEE 626
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 555 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH--LRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDEL 632
Cdd:PRK03918 627 ELDKAFEELAETEKRLEELRKELEELEKKYSEEEYeeLREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706
|
....*...
gi 767972910 633 LEKERQWE 640
Cdd:PRK03918 707 EKAKKELE 714
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
217-809 |
3.96e-15 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 81.26 E-value: 3.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 217 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH 296
Cdd:PRK03918 144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 297 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKETLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 376
Cdd:PRK03918 224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 377 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLRE 456
Cdd:PRK03918 282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 457 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 531
Cdd:PRK03918 350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 532 FDALRNS------CTVITDLEEQLNQLTEDNAELNNqnfyLSKQLDEASganDEIVQLRSEVDHLRREItEREMQLTSQK 605
Cdd:PRK03918 428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKR----IEKELKEIE---EKERKLRKELRELEKVL-KKESELIKLK 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 606 QTMEALKTTCTMLEE-QVMDLEALNDE---LLEKERQWEAWRSVLGDE---KSQFECRVRELQRMLDTEKQSRARADQRI 678
Cdd:PRK03918 500 ELAEQLKELEEKLKKyNLEELEKKAEEyekLKEKLIKLKGEIKSLKKElekLEELKKKLAELEKKLDELEEELAELLKEL 579
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 679 TE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 751
Cdd:PRK03918 580 EElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEE 659
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 752 Q-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 809
Cdd:PRK03918 660 EyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1-634 |
7.68e-15 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 80.06 E-value: 7.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRL-------HRRVSEVEAVLSQKEVELKASETQRSLLEqdlatyiTECSSLKR 73
Cdd:TIGR04523 59 LDKNLNKDEEKINNSNNKIKILEQQIKDLndklkknKDKINKLNSDLSKINSEIKNDKEQKNKLE-------VELNKLEK 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 74 SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLvsARRRSDLYESELRESRLAAEEF 153
Cdd:TIGR04523 132 QKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQ-----KEELENELNLLEKEK--LNIQKNIDKIKNKLLKLELLLS 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 154 KRKATECQHKLLKAkdqgkpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATellQNIRQAKERAERELEKLQNR 233
Cdd:TIGR04523 205 NLKKKIQKNKSLES---------QISELKKQNNQLKDNIEKKQQEINEKTTEISNTQ---TQLNQLKDEQNKIKKQLSEK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 EDSSEGIRKKLVEAEERRHSLENKVKRLETMERRE--NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLK 311
Cdd:TIGR04523 273 QKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDwnKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 312 QKEQHYEEKikvlDNQIKKDLADKETLENMMQRHEEEahekgkilseqkamINAMDSKIRSLEQRIVELSEANKLaanss 391
Cdd:TIGR04523 353 NSESENSEK----QRELEEKQNEIEKLKKENQSYKQE--------------IKNLESQINDLESKIQNQEKLNQQ----- 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 392 lftqrnmkaQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETrlrevSLEHEEQKLE---- 467
Cdd:TIGR04523 410 ---------KDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN-----TRESLETQLKvlsr 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 468 ----LKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleETTAEAEEEIQALTAHRDEIQRKFDALRNSC---- 539
Cdd:TIGR04523 476 sinkIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLT----KKISSLKEKIEKLESEKKEKESKISDLEDELnkdd 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 540 ---------TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDeasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEA 610
Cdd:TIGR04523 552 felkkenleKEIDEKNKEIEELKQTQKSLKKKQEEKQELID----------QKEKEKKDLIKEIEEKEKKISSLEKELEK 621
|
650 660
....*....|....*....|....
gi 767972910 611 LKTTCTMLEEQVMDLEALNDELLE 634
Cdd:TIGR04523 622 AKKENEKLSSIIKNIKSKKNKLKQ 645
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
186-877 |
5.02e-14 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 77.80 E-value: 5.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 186 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEgiRKKLVEAEERRHSLENKVKRLETME 265
Cdd:TIGR02169 166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLK--EKREYEGYELLKEKEALERQKEAIE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 266 RRENRLKDDIQTKSQQIQQMADKILELEEKHRE-------------AQVSAQHLEVH-----LKQKEQHYEEKIKVLDNQ 327
Cdd:TIGR02169 244 RQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkikdlgeeeqLRVKEKIGELEaeiasLERSIAEKERELEDAEER 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 328 IKKDLAD----KETLENMMQRHEEEAHEKGKILSEqkamINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEE 403
Cdd:TIGR02169 324 LAKLEAEidklLAEIEELEREIEEERKRRDKLTEE----YAELKEELEDLRAELEEVDKEFAE-------TRDELKDYRE 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 404 MISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK----------RQLT 473
Cdd:TIGR02169 393 KLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEqlaadlskyeQELY 472
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 474 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAE-------------------------------------- 515
Cdd:TIGR02169 473 DLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEvlkasiqgvhgtvaqlgsvgeryataievaagnrlnnv 552
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 516 ---------EEIQALTAHR---------DEIQRK---------------------------------------------- 531
Cdd:TIGR02169 553 vveddavakEAIELLKRRKagratflplNKMRDErrdlsilsedgvigfavdlvefdpkyepafkyvfgdtlvvedieaa 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 532 --------------------------FDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEivqLRS 585
Cdd:TIGR02169 633 rrlmgkyrmvtlegelfeksgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDE---LSQ 709
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 586 EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqvmDLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQR 662
Cdd:TIGR02169 710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEE---DLSSLEQEIENVKSELKELEARIEEleeDLHKLEEALNDLEA 786
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 663 MLDTEKQsraradQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 742
Cdd:TIGR02169 787 RLSHSRI------PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN 860
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 743 ELKQRLLEEQAKLQQQmdlqknhifrltqgLQEALDRADLLKTERSDLEYQLENIQvlyshekvKMEGTISQQtklIDFL 822
Cdd:TIGR02169 861 GKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELE--------RKIEELEAQ---IEKK 915
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 823 QAKMDQPAKKKKGLFSRRKE-DPALPTQVPlqYNELKLALEKEKARCAELEEALQK 877
Cdd:TIGR02169 916 RKRLSELKAKLEALEEELSEiEDPKGEDEE--IPEEELSLEDVQAELQRVEEEIRA 969
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
70-832 |
5.46e-14 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 77.69 E-value: 5.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 70 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 147
Cdd:COG3096 289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 148 LAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQ---LKIQELQEKLEKAvKASTEATELlqNIRQAKERAE 224
Cdd:COG3096 368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQtraIQYQQAVQALEKA-RALCGLPDL--TPENAEDYLA 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 225 RELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRlkddiqtksqqiQQMADKILELEEKHREAQVSAQ 304
Cdd:COG3096 445 AFRAKEQQATEEVLELEQKLSVADAARRQFEKAYELVCKIAGEVER------------SQAWQTARELLRRYRSQQALAQ 512
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 305 ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 375
Cdd:COG3096 513 rlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRA 592
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 376 RIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKN 445
Cdd:COG3096 593 RIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQPGGAEDP 672
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 446 RLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ESQLTAL 489
Cdd:COG3096 673 RLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfdDSVFDAE 752
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 490 QAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtednaelnnqn 563
Cdd:COG3096 753 ELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF----------- 821
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 564 fyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTML---------------EEQVMDLE 626
Cdd:COG3096 822 --VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLnkllpqanlladetlADRLEELR 899
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 627 ALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHK 693
Cdd:COG3096 900 EELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRPHFSYEDA 975
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 694 AEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHifrl 769
Cdd:COG3096 976 VGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADA---- 1051
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972910 770 tqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 832
Cdd:COG3096 1052 -----EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
23-586 |
1.36e-13 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 76.23 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 23 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 102
Cdd:PRK02224 198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETR----DEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 103 LQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQhkllkakdqgkpevgeyakle 182
Cdd:PRK02224 274 REELAEE-----VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELR--------------------- 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 183 kinaeqqlkiQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLE 262
Cdd:PRK02224 328 ----------DRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELE---EEIE 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 263 TMERRENRLKDDIQtksqqiqQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADK 335
Cdd:PRK02224 395 ELRERFGDAPVDLG-------NAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHV 467
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 336 ETLENMMQRHEEEAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELR 409
Cdd:PRK02224 468 ETIEEDRERVEELEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELR 543
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 410 QQKFYLETQAGKLEAQNRKLEEQ----------LEKISHQDHSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSL 479
Cdd:PRK02224 544 ERAAELEAEAEEKREAAAEAEEEaeeareevaeLNSKLAELKERIESLERIRTLLAAIA-DAEDEIERLREKREALAELN 622
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 480 QERESQLTALQAARAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQ 551
Cdd:PRK02224 623 DERRERLAEKRERKRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEE 695
|
570 580 590
....*....|....*....|....*....|....*
gi 767972910 552 LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSE 586
Cdd:PRK02224 696 LRERREALENRVEALEALYDEAEELESMYGDLRAE 730
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
275-895 |
1.45e-13 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 76.31 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 275 IQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQR--HEEEAHE- 351
Cdd:pfam15921 80 LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNtvHELEAAKc 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 352 -KGKILSEQKAMINAMDSKIRSLE---QRI----VELSEAN--KLAANSSLFTQ--RNM-KAQEEMISELRQQKFYLETQ 418
Cdd:pfam15921 160 lKEDMLEDSNTQIEQLRKMMLSHEgvlQEIrsilVDFEEASgkKIYEHDSMSTMhfRSLgSAISKILRELDTEISYLKGR 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 419 AGKLEAQNRKLEEQLE---KISHQDHSDKNRLL----ELE-TRLREVSLEHEEQKLELKRQLTELQLSLQERES----QL 486
Cdd:pfam15921 240 IFPVEDQLEALKSESQnkiELLLQQHQDRIEQLisehEVEiTGLTEKASSARSQANSIQSQLEIIQEQARNQNSmymrQL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 487 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTednAELNNQNFYL 566
Cdd:pfam15921 320 SDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQES---GNLDDQLQKLL---ADLHKREKEL 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 567 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWrsvL 646
Cdd:pfam15921 394 SLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQ---L 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 647 GDEKSQFECRVRELQ-RMLDTEKQSRARADqrITESRQVVELAVKEHKAEILALQQALkeqKLKAESLSDKLNDLEK-KH 724
Cdd:pfam15921 471 ESTKEMLRKVVEELTaKKMTLESSERTVSD--LTASLQEKERAIEATNAEITKLRSRV---DLKLQELQHLKNEGDHlRN 545
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 725 AMLEMNARSLQ--------QKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERS----DLEY 792
Cdd:pfam15921 546 VQTECEALKLQmaekdkviEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDakirELEA 625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 793 QLENIQVlyshEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKglfSRRKEDPALPTqvplQYNELKLALekeKARCAELE 872
Cdd:pfam15921 626 RVSDLEL----EKVKLVNAGSERLRAVKDIKQERDQLLNEVK---TSRNELNSLSE----DYEVLKRNF---RNKSEEME 691
|
650 660
....*....|....*....|...
gi 767972910 873 EALQKTRIELRSAREEAAHRKAT 895
Cdd:pfam15921 692 TTTNKLKMQLKSAQSELEQTRNT 714
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
187-810 |
1.95e-13 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 75.98 E-value: 1.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 187 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegirkkLVEAEERRHSLENKVKRLET--- 263
Cdd:pfam01576 6 EMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETEL-------CAEAEEMRARLAARKQELEEilh 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 264 -MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE---VHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 339
Cdd:pfam01576 79 eLESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQlekVTTEAKIKKLEEDILLLEDQNSKLSKERKLLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 340 ---NMMQRHEEEAHEKGKILSEQKAMINAMdskirsleqrIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 416
Cdd:pfam01576 159 eriSEFTSNLAEEEEKAKSLSKLKNKHEAM----------ISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 417 TQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLeheeQKLELKRQLTELQLSLQERESQLTALQAARAAL 496
Cdd:pfam01576 229 AQIAELRAQLAKKEEELQ--------------AALARLEEETA----QKNNALKKIRELEAQISELQEDLESERAARNKA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 497 ESQLRqakteleettaeaeeeiqaltahrdeiqrkfdalrnsctvitDLEEQLNQLTEDnaelnnqnfyLSKQLDEASGA 576
Cdd:pfam01576 291 EKQRR------------------------------------------DLGEELEALKTE----------LEDTLDTTAAQ 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 577 NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCtmleeqvmdLEALNDELLEKER---QWEAWRSVLGDEKSQF 653
Cdd:pfam01576 319 QELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQA---------LEELTEQLEQAKRnkaNLEKAKQALESENAEL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 654 ECRVRELQRMLDTEKQSRARADQritesrQVVELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNA 731
Cdd:pfam01576 390 QAELRTLQQAKQDSEHKRKKLEG------QLQELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDV 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 732 RSLQQKLETERELKQRllEEQAKLQ-----QQMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKV 806
Cdd:pfam01576 464 SSLESQLQDTQELLQE--ETRQKLNlstrlRQLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKK 531
|
....
gi 767972910 807 KMEG 810
Cdd:pfam01576 532 KLEE 535
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
145-756 |
2.31e-13 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 75.46 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 145 ESRLAAEEFKRKATECQHKLlKAKDQGKPEVGEYAKL---EKINAEQQLKIQELQEKLEKAVKASTEATELLqnirqakE 221
Cdd:PRK02224 173 DARLGVERVLSDQRGSLDQL-KAQIEEKEEKDLHERLnglESELAELDEEIERYEEQREQARETRDEADEVL-------E 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 222 RAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVK-----RLETMERRENRLKD------DIQTKSQQIQQMADKIL 290
Cdd:PRK02224 245 EHEERREELETLEAEIEDLRETIAETEREREELAEEVRdlrerLEELEEERDDLLAEaglddaDAEAVEARREELEDRDE 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 291 ELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKDLADKETLENMMQRHEEEahekgkiLSEQKAMINAMDSKI 370
Cdd:PRK02224 325 ELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEELREEAAELESELEEAREA-------VEDRREEIEELEEEI 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 371 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLEL 450
Cdd:PRK02224 394 EELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETI 470
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 451 EtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQR 530
Cdd:PRK02224 471 E--------EDRERVEELEAELEDLEEEVEEVEERLERAEDLVEA-EDRIERLEERREDLE-------ELIAERRETIEE 534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 531 KfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 610
Cdd:PRK02224 535 K--------------RERAEELRERAAELE----------AEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIES 590
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 611 LKTTCTMLEEqVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvelavk 690
Cdd:PRK02224 591 LERIRTLLAA-IADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYL------- 662
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 691 ehkaeilalqqalkeqklkaESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQ 756
Cdd:PRK02224 663 --------------------EQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVE 708
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
177-621 |
2.63e-13 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 74.80 E-value: 2.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 177 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKL----------VE 246
Cdd:COG4717 54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLekllqllplyQE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 247 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSQQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 318
Cdd:COG4717 134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 319 EKIKVLDNQIKKDLADKETLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 396
Cdd:COG4717 213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 397 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREV-----SLEHEEQKLELKRQ 471
Cdd:COG4717 293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 472 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 537
Cdd:COG4717 369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 538 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 617
Cdd:COG4717 440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLALELLEEAREE 508
|
....
gi 767972910 618 LEEQ 621
Cdd:COG4717 509 YREE 512
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
43-613 |
3.98e-13 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 74.55 E-value: 3.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 43 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 120
Cdd:PRK01156 172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 121 MMNQLEEdlvSARRRSDLYESELRESRLAAEEFKRKATECQHKLL--KAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 198
Cdd:PRK01156 244 LSSLEDM---KNRYESEIKTAESDLSMELEKNNYYKELEERHMKIinDPVYKNRNYINDYFKYKNDIENKKQILSNIDAE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 199 LEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEErrhSLENKVKRLETMERRENRLKDDIQTK 278
Cdd:PRK01156 321 INKYHAIIKKLSVL-QKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLK---SIESLKKKIEEYSKNIERMSAFISEI 396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 279 SQQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEKIKVLDNQIK-----KDLADkETLENMMQRHE 346
Cdd:PRK01156 397 LKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgTTLGE-EKSNHIINHYN 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 347 EEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEA 424
Cdd:PRK01156 476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 425 QNRKLEeqlekISHQDHSDKNRLLELETRLREVSLEheEQKLELKRQLTELQLSLQERESQLTALQAAraaLESQLRQAK 504
Cdd:PRK01156 556 KSLKLE-----DLDSKRTSWLNALAVISLIDIETNR--SRSNEIKKQLNDLESRLQEIEIGFPDDKSY---IDKSIREIE 625
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 505 TELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLR 584
Cdd:PRK01156 626 NEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD---AKANRARLE 701
|
570 580
....*....|....*....|....*....
gi 767972910 585 SEVDHLRREITEREMQLTSQKQTMEALKT 613
Cdd:PRK01156 702 STIEILRTRINELSDRINDINETLESMKK 730
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
87-760 |
1.42e-12 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 73.08 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 87 DKALQLLHDIREQSRKLqEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLK 166
Cdd:TIGR00618 176 DQYTQLALMEFAKKKSL-HGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQ-KREAQE 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 167 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 246
Cdd:TIGR00618 254 EQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHI-KAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 247 AEERRHSLENKVKRLETMERRENRLKDDIQtKSQQIQQMADKILELEEKHREAQVSAQHLEVHLK---------QKEQHY 317
Cdd:TIGR00618 333 HVKQQSSIEEQRRLLQTLHSQEIHIRDAHE-VATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQslckeldilQREQAT 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 318 EEKIKVLDNQIKKDLADKETLENMMQRHEEE----AHEKGKILSEQKAMINAMDSKIRSLEQRI---------------V 378
Cdd:TIGR00618 412 IDTRTSAFRDLQGQLAHAKKQQELQQRYAELcaaaITCTAQCEKLEKIHLQESAQSLKEREQQLqtkeqihlqetrkkaV 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 379 ELSEANKLAANSSLFTQR----NMKAQEEMISE--------LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNR 446
Cdd:TIGR00618 492 VLARLLELQEEPCPLCGScihpNPARQDIDNPGpltrrmqrGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 447 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 526
Cdd:TIGR00618 572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHAL 651
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 527 EIQRKFDALRNSCTVITDLEEQLNQLTEDN-AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 605
Cdd:TIGR00618 652 QLTLTQERVREHALSIRVLPKELLASRQLAlQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLG 731
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 606 QTMEAlkttctmleeqvmDLEALNDEL--LEKERQWEAWRSVLGDEKSQFECRVRElqrMLDTEKQSRARADQRITESRQ 683
Cdd:TIGR00618 732 SDLAA-------------REDALNQSLkeLMHQARTVLKARTEAHFNNNEEVTAAL---QTGAELSHLAAEIQFFNRLRE 795
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 684 VVELAVKEHKAEILA-----LQQALKEQKLKAESLSDKLNDLEKKHAMLeMNARSLQQKLETERELKQRLLEEQAKLQQQ 758
Cdd:TIGR00618 796 EDTHLLKTLEAEIGQeipsdEDILNLQCETLVQEEEQFLSRLEEKSATL-GEITHQLLKYEECSKQLAQLTQEQAKIIQL 874
|
..
gi 767972910 759 MD 760
Cdd:TIGR00618 875 SD 876
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
140-849 |
1.72e-12 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 72.45 E-value: 1.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 140 ESELRESRLAAEEfKRKATECQHKLLKAKDQGKpevgeyaklEKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--R 217
Cdd:pfam05483 98 EAELKQKENKLQE-NRKIIEAQRKAIQELQFEN---------EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaR 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 218 QAKERAERELEKLQNRE---DSSEGIRKKLVEAEERRHSLEN-------KVKR-LETMERRENRLKDDIQTKSQQIQQMA 286
Cdd:pfam05483 167 SAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAENarlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 287 DKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMqrhEEEAHEKGKILSEQKAMINAM 366
Cdd:pfam05483 247 IQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 367 DSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ 439
Cdd:pfam05483 320 QIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKF 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 440 DHSDKNRLLELETRLREVSLEHEEQKL------ELKRQLTELQLSLQERES-------QLTALQAARAALESQLRQAKTE 506
Cdd:pfam05483 400 KNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQELIFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTE 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 507 LEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQLNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSE 586
Cdd:pfam05483 480 LEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLELKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDE 549
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 587 VDHLRREIteremqltsqKQTMEALKTTCTMLEEQVMDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMldt 666
Cdd:pfam05483 550 LESVREEF----------IQKGDEVKCKLDKSEENARSIEY---EVLKKEKQMKILENKCNNLKKQIENKNKNIEEL--- 613
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 667 EKQSRARADQRITESRQvveLAVKEHKAEILALQQALKEQKLKaESLSDKLNDLEKKhamlemnaRSLQQKLETERELKQ 746
Cdd:pfam05483 614 HQENKALKKKGSAENKQ---LNAYEIKVNKLELELASAKQKFE-EIIDNYQKEIEDK--------KISEEKLLEEVEKAK 681
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 747 RLLEEQAKLQQQMDLQKNH-IFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAK 825
Cdd:pfam05483 682 AIADEAVKLQKEIDKRCQHkIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQ 761
|
730 740
....*....|....*....|....
gi 767972910 826 MDQPAKKKKGLFSRRKEDPALPTQ 849
Cdd:pfam05483 762 LEIEKEEKEKLKMEAKENTAILKD 785
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
94-798 |
2.62e-12 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 72.30 E-value: 2.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 94 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKATECQHKLL 165
Cdd:PRK04863 307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALRQQEKIERYQADLEELEERleEQNEVVEEADEQQEENEARAE 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 166 KAKDqgkpevgEYAKLEKINAEQQLKIQELQEK---LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRK 242
Cdd:PRK04863 387 AAEE-------EVDELKSQLADYQQALDVQQTRaiqYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE---ATE 456
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 243 KLVEAEERRHSLENKVKRLETMERRENRLKDDIqTKSQQIQQMADKILELEEKHREAQvSAQHLEVHLKQKEQHYEEKIK 322
Cdd:PRK04863 457 ELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEV-SRSEAWDVARELLRRLREQRHLAE-QLQQLRMRLSELEQRLRQQQR 534
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 323 V--LDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFT 394
Cdd:PRK04863 535 AerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALAR 614
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 395 QRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE--HEEQ 464
Cdd:PRK04863 615 LREQSGEEfedsQDVTEYMQQLLERERELtverDELAARKQALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDV 694
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 465 KLE-----------------------LKRQLTELQ-----LSLQE------RESQLTALQAARAAL----ESQLRQAKTE 506
Cdd:PRK04863 695 SLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcpedLYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFP 774
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 507 LEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLR 584
Cdd:PRK04863 775 EVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSRFI-------GSHLAVAFEADP----EAELRQLN 843
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 585 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---------------EQVMDLEALNDELLEKER----------QW 639
Cdd:PRK04863 844 RRRVELERALADHESQEQQQRSQLEQAKEGLSALNrllprlnlladetlaDRVEEIREQLDEAEEAKRfvqqhgnalaQL 923
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 640 EAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEILA----LQQALKEQKLKAES 712
Cdd:PRK04863 924 EPIVSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAfalTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQ 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 713 LSDKLNDLEKKHA--MLEMNAR------SLQQKLETERELKQRL----------LEEQAKLQQQmdlqknhifRLTQGLQ 774
Cdd:PRK04863 1000 ERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQELKQELqdlgvpadsgAEERARARRD---------ELHARLS 1070
|
810 820
....*....|....*....|....
gi 767972910 775 EALDRADLLKTERSDLEYQLENIQ 798
Cdd:PRK04863 1071 ANRSRRNQLEKQLTFCEAEMDNLT 1094
|
|
| C1_MgcRacGAP |
cd20821 |
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ... |
957-1011 |
2.93e-12 |
|
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410371 Cd Length: 55 Bit Score: 62.81 E-value: 2.93e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 957 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 1011
Cdd:cd20821 1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
429-889 |
3.11e-12 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 71.61 E-value: 3.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 429 LEEQLEKISHQDHSDknRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 505
Cdd:PRK02224 192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 506 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 577
Cdd:PRK02224 269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 578 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 657
Cdd:PRK02224 349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 658 RELQRMLDTEKQSRARAD------------QRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN------D 719
Cdd:PRK02224 429 AELEATLRTARERVEEAEalleagkcpecgQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraedlvE 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 720 LEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 792
Cdd:PRK02224 507 AEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 793 QLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCAELE 872
Cdd:PRK02224 587 RIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKRELE 640
|
490
....*....|....*...
gi 767972910 873 EALQKTRIE-LRSAREEA 889
Cdd:PRK02224 641 AEFDEARIEeAREDKERA 658
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
1-485 |
3.42e-12 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 71.69 E-value: 3.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQAR 79
Cdd:pfam15921 347 LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRN 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 80 MEV-----------SQEDDKALQLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLV--------SARRRSDLYE 140
Cdd:pfam15921 426 MEVqrleallkamkSECQGQMERQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTakkmtlesSERTVSDLTA 503
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 141 SeLRESRLAAEEFKRKAT-----------ECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVK----- 204
Cdd:pfam15921 504 S-LQEKERAIEATNAEITklrsrvdlklqELQH-LKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQlvgqh 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 205 ASTEATELLQNIRQAKERAERELEkLQNREDSSEGIRKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSQQIQ 283
Cdd:pfam15921 582 GRTAGAMQVEKAQLEKEINDRRLE-LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGSERLRAVKDIKQERDQLLN 660
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 284 QMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMI 363
Cdd:pfam15921 661 EVKTSRNELNSLSEDYEV----LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQI 736
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 364 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlekishqdhsd 443
Cdd:pfam15921 737 TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE------------ 804
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 767972910 444 knRLLELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 485
Cdd:pfam15921 805 --KVANMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
31-601 |
4.34e-12 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 71.30 E-value: 4.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 31 RRVSEVEAVLSQKEVELKAS----ETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEI 106
Cdd:pfam15921 317 RQLSDLESTVSQLRSELREAkrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 107 KEQeyqaqveEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAeEFKRKATECQHKLLK--AKDQGKPEvgeyaKLEKI 184
Cdd:pfam15921 397 KEQ-------NKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA-LLKAMKSECQGQMERqmAAIQGKNE-----SLEKV 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 185 NAeQQLKIQELQEKLEKAVKASTEATELLQNirqaKERAEREL-EKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLET 263
Cdd:pfam15921 464 SS-LTAQLESTKEMLRKVVEELTAKKMTLES----SERTVSDLtASLQEKERAIEATNAEITKLRSR---VDLKLQELQH 535
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 264 MERRENRLKdDIQTKSQQIQqmadkiLELEEKHREAQVSAQHLEVHLKQKEQHYEE--KIKVLDNQIKKDLADKEtLEnm 341
Cdd:pfam15921 536 LKNEGDHLR-NVQTECEALK------LQMAEKDKVIEILRQQIENMTQLVGQHGRTagAMQVEKAQLEKEINDRR-LE-- 605
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 342 mqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAG 420
Cdd:pfam15921 606 --------------LQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVK 663
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 421 KLEAQNRKLEEQLEKishqdhsdknrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQ 499
Cdd:pfam15921 664 TSRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVA 729
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 500 LRQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASG 575
Cdd:pfam15921 730 MGMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNK 787
|
570 580
....*....|....*....|....*.
gi 767972910 576 ANDEIVQLRSEVDHLRREITEREMQL 601
Cdd:pfam15921 788 MAGELEVLRSQERRLKEKVANMEVAL 813
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
87-773 |
7.48e-12 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 70.77 E-value: 7.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 87 DKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKR--------KAT 158
Cdd:TIGR00618 200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARieelraqeAVL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 159 ECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNiRQAKERAERELEKLQNREDSSE 238
Cdd:TIGR00618 280 EETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEIHIR 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 239 -------GIRKKLVEAEERRHSLENKVKRLETMERRENRLKddiqTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLK 311
Cdd:TIGR00618 359 dahevatSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLC----KELDILQREQATIDTRTSAFRDLQGQLAHAKKQQE 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 312 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKG--KILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAN 389
Cdd:TIGR00618 435 LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQtkEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPN 514
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 390 SSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELK 469
Cdd:TIGR00618 515 PARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITV 594
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 470 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 549
Cdd:TIGR00618 595 RLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKEL 674
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 550 NQLTEDN-AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL--E 626
Cdd:TIGR00618 675 LASRQLAlQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQarT 754
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 627 ALNDELLEKERQWEAWRSVL--GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKehkAEILALQQALK 704
Cdd:TIGR00618 755 VLKARTEAHFNNNEEVTAALqtGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILN---LQCETLVQEEE 831
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 705 EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGL 773
Cdd:TIGR00618 832 QFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHEI 900
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
541-893 |
9.53e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 70.47 E-value: 9.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 541 VITDLEEQLNQLtEDNAELNNQNFYLSKQLDEAsgandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 620
Cdd:TIGR02168 194 ILNELERQLKSL-ERQAEKAERYKELKAELREL-----ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEE 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 621 QvmdLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavKEHKAEIL 697
Cdd:TIGR02168 268 K---LEELRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELESK-----LDELAEEL 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 698 A-LQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrlleEQAKLQQQMDLQKNHIFRLTQGLQEA 776
Cdd:TIGR02168 340 AeLEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS-------KVAQLELQIASLNNEIERLEARLERL 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 777 LDRADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNE 856
Cdd:TIGR02168 413 EDRRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDA 479
|
330 340 350
....*....|....*....|....*....|....*..
gi 767972910 857 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 893
Cdd:TIGR02168 480 AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
8-354 |
1.93e-11 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 69.40 E-value: 1.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 8 KSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDD 87
Cdd:PTZ00121 1458 KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD 1537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 KALQLLHDIR-EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLyeselresrlaAEEFKRKATECQHKLLK 166
Cdd:PTZ00121 1538 EAKKAEEKKKaDELKKAEELKKAEEKKKAEEAK----KAEEDKNMALRKAEE-----------AKKAEEARIEEVMKLYE 1602
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 167 AKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKEraERELEKLQNREDSSEGIRKklve 246
Cdd:PTZ00121 1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIKAAEEAKKAEEDKKK---- 1676
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 247 AEERRHSLENKVKRLETMERRENRLKDDIQTKSQQiqqmADKILELEEKHREAQVSAQHLEvHLKQKEQhyEEKIKVldN 326
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKE----AEEKKKAEELKKAEEENKIKAE-EAKKEAE--EDKKKA--E 1747
|
330 340
....*....|....*....|....*...
gi 767972910 327 QIKKDLADKETLENMMQRHEEEAHEKGK 354
Cdd:PTZ00121 1748 EAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
124-556 |
4.13e-11 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 67.87 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 124 QLEEDLVSARRRSDLY---ESELRESRLAAEEFKRKATECQHKL--LKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEK 198
Cdd:COG4717 75 ELEEELKEAEEKEEEYaelQEELEELEEELEELEAELEELREELekLEKLLQLLPLYQELEALEAELAELPERLEELEER 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 199 LEKAVKASTEATELLQNIRQAKERAERELEKLqnredsSEGIRKKLVEAEERRHSLENKVKRLetmERRENRLKDDIQTK 278
Cdd:COG4717 155 LEELRELEEELEELEAELAELQEELEELLEQL------SLATEEELQDLAEELEELQQRLAEL---EEELEEAQEELEEL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 279 SQQIQQMADKILELEEKHR-------------------------------------EAQVSAQHLEVHLKQKEQHYEEKI 321
Cdd:COG4717 226 EEELEQLENELEAAALEERlkearlllliaaallallglggsllsliltiagvlflVLGLLALLFLLLAREKASLGKEAE 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 322 KVLDNQIKKDLADKEtLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 401
Cdd:COG4717 306 ELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDE 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 402 EEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ 480
Cdd:COG4717 385 EELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEELEEELEELEEELEELREELAELEAELE 463
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 481 ERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKfdalrnsctVITDLEEQLNQLTEDN 556
Cdd:COG4717 464 QLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP---------VLERASEYFSRLTDGR 532
|
|
| C1_ScPKC1-like_rpt2 |
cd20823 |
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
955-1012 |
7.43e-11 |
|
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410373 Cd Length: 59 Bit Score: 58.86 E-value: 7.43e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 955 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 1012
Cdd:cd20823 1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
|
|
| ROM1 |
COG5422 |
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ... |
1212-1463 |
9.57e-11 |
|
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];
Pssm-ID: 227709 [Multi-domain] Cd Length: 1175 Bit Score: 67.22 E-value: 9.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1212 SDQVVLVGTEEGLYALNVLKNS--------LTHVPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1283
Cdd:COG5422 868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1284 aqpDISPNIFEAVK-----GCHLFGAGKiENGLCICAAMPSKVVILRYN------ENLSKYCIRKEIETSEPCScIHFTN 1352
Cdd:COG5422 944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNksgnlkKALTIELSTELYVPSEPLS-VHFLK 1018
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1353 YSILIGTNKFYEI-DMKQYTLEEFLDKNDHSlaPAVFAASSNSFPVSIVQVNSagqreEYLLCFHEFGVFVDSYGRRSRT 1431
Cdd:COG5422 1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091
|
250 260 270
....*....|....*....|....*....|...
gi 767972910 1432 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1463
Cdd:COG5422 1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
8-793 |
1.24e-10 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 66.61 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 8 KSKELQDSQDKCHKMEQEMTRLHRRVSEVEavLSQKEVELKASETQrslleqdlatyiteCSSLKRSLEQARMEVSQEDD 87
Cdd:TIGR00606 317 KERELVDCQRELEKLNKERRLLNQEKTELL--VEQGRLQLQADRHQ--------------EHIRARDSLIQSLATRLELD 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 kALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKA 167
Cdd:TIGR00606 381 -GFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFV 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 168 KDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 246
Cdd:TIGR00606 460 IKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEVKsLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEM 539
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 247 AEERRHSLENKVKRLETMERRE-----------NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQ 315
Cdd:TIGR00606 540 LTKDKMDKDEQIRKIKSRHSDEltsllgyfpnkKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEE 619
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 316 H---YEEKIKvldnqikkDLADKETLENMMQRHEEEAHEKGKilseQKAMINAmdsKIRSLEQRIVELSEANKLAANSSL 392
Cdd:TIGR00606 620 QlssYEDKLF--------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---ATAVYSQFITQLTDENQSCCPVCQ 684
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 393 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN-------RLLELETRLREVSLEHEEQK 465
Cdd:TIGR00606 685 RVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSiidlkekEIPELRNKLQKVNRDIQRLK 764
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 466 LELKRQLTELQLSLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNS 538
Cdd:TIGR00606 765 NDIEEQETLLGTIMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSK 844
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 539 C----TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEalktt 614
Cdd:TIGR00606 845 IelnrKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLE----- 919
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 615 ctmleeqvmDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRqvvELAVKEHKA 694
Cdd:TIGR00606 920 ---------KDQQEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGK---DDYLKQKET 977
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 695 EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ETERELKQRLLE-----------EQA 753
Cdd:TIGR00606 978 ELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEVEEELKQHLKEmgqmqvlqmkqEHQ 1057
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 767972910 754 KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 793
Cdd:TIGR00606 1058 KLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
347-798 |
2.01e-10 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 66.09 E-value: 2.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 347 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 423
Cdd:COG4913 238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 424 AQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 499
Cdd:COG4913 316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 500 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 558
Cdd:COG4913 396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 559 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREI-TEREMQLTSQKQTMEALKTTctmleeqvmdle 626
Cdd:COG4913 476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLvYERVRTGLPDPERPRLDPDS------------ 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 627 aLNDELLEKERQWEAW-RSVLGDEKSqFEC--RVRELQR---------MLDTEKQSRARADQRITESRQV----VELAVK 690
Cdd:COG4913 536 -LAGKLDFKPHPFRAWlEAELGRRFD-YVCvdSPEELRRhpraitragQVKGNGTRHEKDDRRRIRSRYVlgfdNRAKLA 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 691 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM---------NARSLQQKLETERELKQRLLEEQ---AKLQQQ 758
Cdd:COG4913 614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLDASSddlAALEEQ 693
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 767972910 759 MDlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 798
Cdd:COG4913 694 LE-------ELEAELEELEEELDELKGEIGRLEKELEQAE 726
|
|
| C1 |
smart00109 |
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ... |
959-1007 |
2.01e-10 |
|
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.
Pssm-ID: 197519 Cd Length: 50 Bit Score: 57.48 E-value: 2.01e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767972910 959 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1007
Cdd:smart00109 1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
269-763 |
2.02e-10 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 65.69 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 269 NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKETLENMMQRHEEE 348
Cdd:PRK01156 186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 349 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 428
Cdd:PRK01156 258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 429 LEE------QLEKISHQDHSDKNRLLELET----------RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 492
Cdd:PRK01156 331 LSVlqkdynDYIKKKSRYDDLNNQILELEGyemdynsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 493 RAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYLS 567
Cdd:PRK01156 411 LNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKIR 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 568 KQLDEASGANDEIVQLRSEVDHLR-----------REITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKE 636
Cdd:PRK01156 487 EIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSK 566
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 637 R-QW------------EAWRSVLGDEKSQF---ECRVRELQ--------------RMLDTE------KQSRARADQRITE 680
Cdd:PRK01156 567 RtSWlnalavislidiETNRSRSNEIKKQLndlESRLQEIEigfpddksyidksiREIENEannlnnKYNEIQENKILIE 646
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 681 SRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQ 756
Cdd:PRK01156 647 KLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETLE 726
|
....*..
gi 767972910 757 QQMDLQK 763
Cdd:PRK01156 727 SMKKIKK 733
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
10-502 |
2.02e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 65.83 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLS---QKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQED 86
Cdd:PRK02224 213 SELAELDEEIERYEEQREQARETRDEADEVLEeheERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 87 DKALQLLHD---------IREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKA 157
Cdd:PRK02224 293 EERDDLLAEaglddadaeAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESEL 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 158 TECQHKLLKAKDQGKPEVGEYAKLEKI--NAEQQL-----KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEK- 229
Cdd:PRK02224 373 EEAREAVEDRREEIEELEEEIEELRERfgDAPVDLgnaedFLEELREERDELREREAELEATLRTARERVEEAEALLEAg 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 230 -----------------LQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM---ERRENRLKDDIQTKSQQIQQMADKI 289
Cdd:PRK02224 453 kcpecgqpvegsphvetIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLveaEDRIERLEERREDLEELIAERRETI 532
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 290 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvlDNQIKKDLADKETLENMMQRHEEEAHEKGKIlSEQKAMINAMDSK 369
Cdd:PRK02224 533 EEKRERAEELRERAAELEAEAEEKREAAAEA----EEEAEEAREEVAELNSKLAELKERIESLERI-RTLLAAIADAEDE 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 370 IRSLEQRIVELSEAN-----KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 444
Cdd:PRK02224 608 IERLREKREALAELNderreRLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVE 687
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 445 NRLLELEtRLREvslEHEEqklelkrqltelqlsLQERESQLTA-------LQAARAALESQLRQ 502
Cdd:PRK02224 688 NELEELE-ELRE---RREA---------------LENRVEALEAlydeaeeLESMYGDLRAELRQ 733
|
|
| C1 |
cd00029 |
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ... |
959-1007 |
2.41e-10 |
|
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.
Pssm-ID: 410341 Cd Length: 50 Bit Score: 57.14 E-value: 2.41e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767972910 959 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd00029 1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
287-772 |
4.08e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 64.40 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 287 DKILELEEKHREAQVSAQHLEVHLKQKEQhYEEKIKVLDNQIKKDLADKETLEnmmqrHEEEAHEKGKILSEQKAMINAM 366
Cdd:COG4717 71 KELKELEEELKEAEEKEEEYAELQEELEE-LEEELEELEAELEELREELEKLE-----KLLQLLPLYQELEALEAELAEL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 367 DSKIRSLEQRIVELSEankLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNR 446
Cdd:COG4717 145 PERLEELEERLEELRE---LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEE 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 447 LLELETRLREVSLEHEEQKLElkRQLTELQLSLqeresqltALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 526
Cdd:COG4717 222 LEELEEELEQLENELEAAALE--ERLKEARLLL--------LIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 527 EIQRKFDALRNSCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREitEREMQLTSQK 605
Cdd:COG4717 292 LLAREKASLGKEAEELQALPALEElEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEEL--EEELQLEELE 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 606 QTMEALkttctMLEEQVMDLEALNdELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARAD-QRITESRQV 684
Cdd:COG4717 370 QEIAAL-----LAEAGVEDEEELR-AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEElEELEEELEE 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 685 VELAVKEHKAEILALQQALK---------EQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAkl 755
Cdd:COG4717 444 LEEELEELREELAELEAELEqleedgelaELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA-- 521
|
490
....*....|....*...
gi 767972910 756 qqqmdlqkNHIF-RLTQG 772
Cdd:COG4717 522 --------SEYFsRLTDG 531
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
85-683 |
4.52e-10 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 64.94 E-value: 4.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 85 EDDKALQLLHDIreQSRK----LQE-IKEQ-----EYQAQVEEMRLMMNQL---EEDLVSARRRSDLyeseLRESRLAAE 151
Cdd:COG4913 189 GSEKALRLLHKT--QSFKpigdLDDfVREYmleepDTFEAADALVEHFDDLeraHEALEDAREQIEL----LEPIRELAE 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 152 EFKRKATECQHklLKAkdqgkpeVGEYAKLEkinaEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQ 231
Cdd:COG4913 263 RYAAARERLAE--LEY-------LRAALRLW----FAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 232 NREDSSEGIRKKLVEAEerrhsLENKVKRLETMERRENRLKDDIQT--------------KSQQIQQMADKILELEEKHR 297
Cdd:COG4913 330 AQIRGNGGDRLEQLERE-----IERLERELEERERRRARLEALLAAlglplpasaeefaaLRAEAAALLEALEEELEALE 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 298 EAQVSAQHLEVHLKQKEQHYEEKIKVLDN--------------QIKKDLADKET----LENMMQRHEEEAHEKGKI---- 355
Cdd:COG4913 405 EALAEAEAALRDLRRELRELEAEIASLERrksniparllalrdALAEALGLDEAelpfVGELIEVRPEEERWRGAIervl 484
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 356 -------------LSEQKAMINAMDSKIR------------SLEQRIVELSEANKLAANSSLFTQRnmkAQEEM------ 404
Cdd:COG4913 485 ggfaltllvppehYAAALRWVNRLHLRGRlvyervrtglpdPERPRLDPDSLAGKLDFKPHPFRAW---LEAELgrrfdy 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 405 -----ISELRQQKFYLeTQAGKLeAQNRKLEEqlekisHQDHSdknrlleletRLREVSL---EHEEQKLELKRQLTELQ 476
Cdd:COG4913 562 vcvdsPEELRRHPRAI-TRAGQV-KGNGTRHE------KDDRR----------RIRSRYVlgfDNRAKLAALEAELAELE 623
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 477 LSLQERESQLTALQAARAALESQLRQakteleettaeaeeeIQALTAHRDEIQRKFDALRNsctvITDLEEQLNQLTEDN 556
Cdd:COG4913 624 EELAEAEERLEALEAELDALQERREA---------------LQRLAEYSWDEIDVASAERE----IAELEAELERLDASS 684
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 557 AELNNqnfyLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEke 636
Cdd:COG4913 685 DDLAA----LEEQLEE---LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR---LEAAEDLARLELRALLE-- 752
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 767972910 637 rqwEAWRSVLGDEKSQfecRVRE-LQRMLDTEKQSRARADQRITESRQ 683
Cdd:COG4913 753 ---ERFAAALGDAVER---ELREnLEERIDALRARLNRAEEELERAMR 794
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
338-574 |
4.73e-10 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 64.27 E-value: 4.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 338 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 417
Cdd:COG3206 162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 418 QAGKLEAQNRKLEEQLEKISHQ--DHSDKNRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 495
Cdd:COG3206 234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 496 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 574
Cdd:COG3206 303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2-795 |
6.31e-10 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 64.43 E-value: 6.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam01576 4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEefkRKATEcq 161
Cdd:pfam01576 84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKE---RKLLE-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 162 HKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKAsteatellqniRQAKERAERELEKLQNreDSSEGIR 241
Cdd:pfam01576 159 ERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKG-----------RQELEKAKRKLEGEST--DLQEQIA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 242 KKLVEAEERRHSLENKVKRLETMerrENRLKDDIQTKSQqiqqmadkileLEEKHREAQVSAQHLEVHLKQkEQHYEEKI 321
Cdd:pfam01576 226 ELQAQIAELRAQLAKKEEELQAA---LARLEEETAQKNN-----------ALKKIRELEAQISELQEDLES-ERAARNKA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 322 KVLDNQIKKDL-ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeanklaansslftQRNMKA 400
Cdd:pfam01576 291 EKQRRDLGEELeALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMR-------------QKHTQA 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 401 QEEMISELRQQKFY---LETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEH---EEQKLELKRQLTE 474
Cdd:pfam01576 358 LEELTEQLEQAKRNkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAEKLSK 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 475 LQL-------SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEiqrkfdalRNSctvitdLEE 547
Cdd:pfam01576 438 LQSelesvssLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDE--------RNS------LQE 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 548 QLNQLTEDNAE-------LNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEE 620
Cdd:pfam01576 504 QLEEEEEAKRNverqlstLQAQLSDMKKKLEEDAGTLEALEEGKKR---LQRELEALTQQLEEKAAAYDKLEKTKNRLQQ 580
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 621 QVMDL-------EALNDELLEKERQWE-------AWRSVLGDEKSQFECRVRElqrmLDTEKQSRARADQRITESRQVVE 686
Cdd:pfam01576 581 ELDDLlvdldhqRQLVSNLEKKQKKFDqmlaeekAISARYAEERDRAEAEARE----KETRALSLARALEEALEAKEELE 656
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 687 LAVKEHKAEI---------------------LALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ---------- 735
Cdd:pfam01576 657 RTNKQLRAEMedlvsskddvgknvhelerskRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKaqferdlqar 736
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 736 ---------------QKLETER--ELKQRLLEEQAKLQQQMDLQ--KNHIFRLTQGLQEALDRADLLKTERSDLEYQLE 795
Cdd:pfam01576 737 deqgeekrrqlvkqvRELEAELedERKQRAQAVAAKKKLELDLKelEAQIDAANKGREEAVKQLKKLQAQMKDLQRELE 815
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
7-476 |
7.14e-10 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 64.30 E-value: 7.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 7 IKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDL------ATYITECSSLKRSLEQARM 80
Cdd:TIGR00606 574 QLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQDEESDLERLKEEIEKSSK 653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 81 EVSQEDDKAL---QLLHDIREQSRKLQEIKEQEYQAQvEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKA 157
Cdd:TIGR00606 654 QRAMLAGATAvysQFITQLTDENQSCCPVCQRVFQTE-AELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLA 732
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 158 tECQHKLLKAKDQGKPEVGEyaKLEKINAEQQLKIQEL--QEKLEKAVKASTEATE-------LLQNIRQAKERAERELE 228
Cdd:TIGR00606 733 -PGRQSIIDLKEKEIPELRN--KLQKVNRDIQRLKNDIeeQETLLGTIMPEEESAKvcltdvtIMERFQMELKDVERKIA 809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 229 KLQNREDSSEGIRKklveAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQVSAQH 305
Cdd:TIGR00606 810 QQAAKLQGSDLDRT----VQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKlqiGTNLQRRQQ 885
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 306 LEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI-------RSLEQRIV 378
Cdd:TIGR00606 886 FEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVknihgymKDIENKIQ 965
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 379 E---------LSEANKLAANSSLFTQRNMKAQEEM------ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 443
Cdd:TIGR00606 966 DgkddylkqkETELNTVNAQLEECEKHQEKINEDMrlmrqdIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMG 1045
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 767972910 444 KNRLLE-------LETRLREVSLEH----------EEQKLELKRQLTELQ 476
Cdd:TIGR00606 1046 QMQVLQmkqehqkLEENIDLIKRNHvlalgrqkgyEKEIKHFKKELREPQ 1095
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
429-889 |
7.36e-10 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 63.63 E-value: 7.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 429 LEEQLEKISHQDHSDKNRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 507
Cdd:COG4717 47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 508 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgANDEIVQLRSEV 587
Cdd:COG4717 126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA--TEEELQDLAEEL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 588 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNdELLEKERQWEAWRSVL-----GDEKSQFECRVRELQR 662
Cdd:COG4717 202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLallglGGSLLSLILTIAGVLF 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 663 MLdtekqSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE--MNARSLQQKLET 740
Cdd:COG4717 281 LV-----LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEllDRIEELQELLRE 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 741 ERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI-----QVLYSHEKVKMEG 810
Cdd:COG4717 356 AEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgeleELLEALDEEELEE 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 811 TISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE---ALQKTRIELRSARE 887
Cdd:COG4717 433 ELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewaALKLALELLEEARE 507
|
..
gi 767972910 888 EA 889
Cdd:COG4717 508 EY 509
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
8-385 |
8.95e-10 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 63.60 E-value: 8.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 8 KSKELQDSQDKCHKMEQEMTRlhrrvseveavlSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDD 87
Cdd:pfam17380 282 KAVSERQQQEKFEKMEQERLR------------QEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERE 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 kalqlLHDIREQSRK--LQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRlaaeefkrkatecqhkll 165
Cdd:pfam17380 350 -----LERIRQEERKreLERIRQEEIAMEISRMR----ELERLQMERQQKNERVRQELEAAR------------------ 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 166 kakdqgkpevgeyaKLEKINAEQQLKIQELQEKLEKAVKASTEATEllQNIRQAKERAERELEKLQNREdssegirkklv 245
Cdd:pfam17380 403 --------------KVKILEEERQRKIQQQKVEMEQIRAEQEEARQ--REVRRLEEERAREMERVRLEE----------- 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 246 eaEERRHSLEnKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyEEKIKVLD 325
Cdd:pfam17380 456 --QERQQQVE-RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEM--EERQKAIY 530
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 326 NQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDsKIRSLEQRIVELSEANK 385
Cdd:pfam17380 531 EEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAME-REREMMRQIVESEKARA 589
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
1-500 |
9.08e-10 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 63.59 E-value: 9.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEM----TRLHRRVSEVEAV--------------LSQKEV---ELKASETQRSLLEQ 59
Cdd:pfam05483 273 LEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALeedlqiatkticqlTEEKEAqmeELNKAKAAHSFVVT 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 60 DLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqLEE-DLVSARRRSDL 138
Cdd:pfam05483 353 EFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------LEElKKILAEDEKLL 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 139 YESELRESrlAAEEFKRKATECQHkLLKAKDQGKPEVGEYAKLEKINAEQQLK-IQELQEKLEKAVKASTEATE-----L 212
Cdd:pfam05483 422 DEKKQFEK--IAEELKGKEQELIF-LLQAREKEIHDLEIQLTAIKTSEEHYLKeVEDLKTELEKEKLKNIELTAhcdklL 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 213 LQNIRQAKERAERELEKLQNREDSSEGIRKKlveaeerrhslENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILEL 292
Cdd:pfam05483 499 LENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCK 567
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 293 EEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEtlENMMQRHEEEAHEKGKILSEQKAMiNAMDSKIRS 372
Cdd:pfam05483 568 LDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEELHQENKALKKKGSAENKQL-NAYEIKVNK 640
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 373 LEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLEAQNR-KLEEQLEKISHQDHSDKNRLLEL 450
Cdd:pfam05483 641 LEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAIADEAvKLQKEIDKRCQHKIAEMVALMEK 711
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 451 ETRLREVSLEHEEQKLELKRQLTELQLSLQER-ESQLTALQAARAALESQL 500
Cdd:pfam05483 712 HKHQYDKIIEERDSELGLYKNKEQEQSSAKAAlEIELSNIKAELLSLKKQL 762
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
8-436 |
9.74e-10 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 64.01 E-value: 9.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 8 KSKELQDSQDKCHKMEQEMTRLHRRVSEVEAvlsQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDD 87
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEA---KKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAE 1567
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 KALqllhdiREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESElrESRLAAEEFkRKATECQHKLLKA 167
Cdd:PTZ00121 1568 EAK------KAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAE--EAKIKAEEL-KKAEEEKKKVEQL 1638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 168 KDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA------KERAERELEKLQNREDSSEGIR 241
Cdd:PTZ00121 1639 KKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAaealkkEAEEAKKAEELKKKEAEEKKKA 1718
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 242 KKLVEAEERRHSLENKVKRLETMERR---ENRLKDDIQTKSQQIQQMADKILELEEKHREAqVSAQHLEVHLKQKEQHYE 318
Cdd:PTZ00121 1719 EELKKAEEENKIKAEEAKKEAEEDKKkaeEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEA-VIEEELDEEDEKRRMEVD 1797
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 319 EKIK-VLDN---------------QIKKDLADKETLE----NMMQRHEEEAHEKGKIL--------SEQKAMINAMDSKI 370
Cdd:PTZ00121 1798 KKIKdIFDNfaniieggkegnlviNDSKEMEDSAIKEvadsKNMQLEEADAFEKHKFNknnengedGNKEADFNKEKDLK 1877
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 371 RSLEQRIVELSEANKLAAN--SSLFTQRNMKAQEEMIselrqqkfyLETQAGKLEAQNRKLEEQLEKI 436
Cdd:PTZ00121 1878 EDDEEEIEEADEIEKIDKDdiEREIPNNNMAGKNNDI---------IDDKLDKDEYIKRDAEETREEI 1936
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
10-385 |
1.00e-09 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 63.55 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKA 89
Cdd:TIGR02169 688 RELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARI 767
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 90 LQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELrESRLAAEEFKRKatecqhkllkakd 169
Cdd:TIGR02169 768 EELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-NRLTLEKEYLEK------------- 833
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 170 qgkpevgEYAKLEKINAEQQLKIQELQEKLEkavkasteatellqNIRQAKERAERELEKLQNREdssEGIRKKLVEAEE 249
Cdd:TIGR02169 834 -------EIQELQEQRIDLKEQIKSIEKEIE--------------NLNGKKEELEEELEELEAAL---RDLESRLGDLKK 889
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 250 RRHSLENKvkrLETMERRENRLKDDIQTKSQQIQQMADKILELEEkhreaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK 329
Cdd:TIGR02169 890 ERDELEAQ---LRELERKIEELEAQIEKKRKRLSELKAKLEALEE-----ELSEIEDPKGEDEEIPEEELSLEDVQAELQ 961
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 330 KDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 385
Cdd:TIGR02169 962 RVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKR 1017
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
101-896 |
1.12e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 63.62 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 101 RKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATEcQHKLLKAKDQGKPEVGEYAK 180
Cdd:PTZ00121 1027 EKIEELTEYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKE-DNRADEATEEAFGKAEEAKK 1105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 181 LEKINAEQQLKIQELQEKLEKAVKAstEATELLQNIRQAKE--RAE--RELEKLQNREDSSEGIRKKLVE----AEERRH 252
Cdd:PTZ00121 1106 TETGKAEEARKAEEAKKKAEDARKA--EEARKAEDARKAEEarKAEdaKRVEIARKAEDARKAEEARKAEdakkAEAARK 1183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 253 SLEnkVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQhlEVHLKQKEQHYEEKIKVLDNQIKKDL 332
Cdd:PTZ00121 1184 AEE--VRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAE--EAKKDAEEAKKAEEERNNEEIRKFEE 1259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 333 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKiRSLEQRIVElsEANKLAANSSLFTQRNMKAQEemiSELRQQK 412
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK-KAEEKKKAD--EAKKKAEEAKKADEAKKKAEE---AKKKADA 1333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 413 FYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAA 492
Cdd:PTZ00121 1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA 1413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 493 RAAlESQLRQAKTELEETTAEAEEEIQALTAHR-DEIQRKFDALRNSctvitdleEQLNQLTEDnaelnnqnfylSKQLD 571
Cdd:PTZ00121 1414 AAA-KKKADEAKKKAEEKKKADEAKKKAEEAKKaDEAKKKAEEAKKA--------EEAKKKAEE-----------AKKAD 1473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 572 EASGANDEivqlRSEVDHLRREITEREMQLTSQKQTMEALKTTctmleeqvmdlealnDELLEKERQWEAWRSVLGDEKS 651
Cdd:PTZ00121 1474 EAKKKAEE----AKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------------DEAKKAEEAKKADEAKKAEEAK 1534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 652 QFEcrvrELQRMLDTEKQSRARADQRITESRQV--VELAVKEHKAEILALQQAlkeqklkaeslsDKLNDLEKKHAMLEM 729
Cdd:PTZ00121 1535 KAD----EAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKA------------EEAKKAEEARIEEVM 1598
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 730 NARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 809
Cdd:PTZ00121 1599 KLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAE 1678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 810 gtisqqtklidflQAKMDQPAKKKKGLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL--EEALQKTRIELRSARE 887
Cdd:PTZ00121 1679 -------------EAKKAEEDEKKAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkkAEEENKIKAEEAKKEA 1739
|
....*....
gi 767972910 888 EAAHRKATD 896
Cdd:PTZ00121 1740 EEDKKKAEE 1748
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
95-695 |
1.13e-09 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 63.40 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 95 DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 174
Cdd:COG4913 263 RYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQ 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 175 V-GEYAKLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQNIRQAKERAER---ELEKLQNREDSsegIRKKLVEAEE 249
Cdd:COG4913 343 LeREIERLERELEERERRRARLEALLAALgLPLPASAEEFAALRAEAAALLEAleeELEALEEALAE---AEAALRDLRR 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 250 RRHSLENKVKRLE----TMERRENRLKDDIqtkSQQIQQMADKI------LELEEKHREAQ---------------VSAQ 304
Cdd:COG4913 420 ELRELEAEIASLErrksNIPARLLALRDAL---AEALGLDEAELpfvgelIEVRPEEERWRgaiervlggfaltllVPPE 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 305 HL--------EVHLKQK-------------------EQHYEEKIKVLDNQ----IKKDLADK------ETLENM------ 341
Cdd:COG4913 497 HYaaalrwvnRLHLRGRlvyervrtglpdperprldPDSLAGKLDFKPHPfrawLEAELGRRfdyvcvDSPEELrrhpra 576
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 342 -----MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSLEQRIVELSEANKLAANSslftQRNMKAQEEMISE 407
Cdd:COG4913 577 itragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAE----LDALQERREALQR 652
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 408 LRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKNRLLELETRLREVSLEH---EEQKLELKRQLTELQLSLQERES 484
Cdd:COG4913 653 LAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQLEELEAELeelEEELDELKGEIGRLEKELEQAEE 727
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 485 QLTALQAA------------RAALESQLRQAKTELEETTAEAEEEiQALTAHRDEIQRKFDALRN------------SCT 540
Cdd:COG4913 728 ELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE-ERIDALRARLNRAEEELERamrafnrewpaeTAD 806
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 541 VITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEIVQLRSEVDHLRREITER----------------- 597
Cdd:COG4913 807 LDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFVADLLSKLRRAIREIKERidplndslkripfgpgr 882
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 598 EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKerqweawrsvlgdeksQFEcRVREL-QRMLDTEKQSRARADQ 676
Cdd:COG4913 883 YLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEA----------------RFA-ALKRLiERLRSEEEESDRRWRA 945
|
730
....*....|....*....
gi 767972910 677 RITESRQVVELAVKEHKAE 695
Cdd:COG4913 946 RVLDVRNHLEFDAEEIDRE 964
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
9-251 |
2.00e-09 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 61.32 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 9 SKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDK 88
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 89 ALQLLHDIREQSRKLQEIKEQEYqaqveeMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKATEcqhklLKAK 168
Cdd:COG4942 99 LEAQKEELAELLRALYRLGRQPP------LALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE-----LAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 169 DQgkpevgeyaKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAE 248
Cdd:COG4942 166 RA---------ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
|
...
gi 767972910 249 ERR 251
Cdd:COG4942 237 AAA 239
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
4-829 |
2.18e-09 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 62.76 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLS---QKEVELKASETQRSLLEQDlatyitecsslKRSLEQARM 80
Cdd:TIGR00606 225 QITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSkimKLDNEIKALKSRKKQMEKD-----------NSELELKME 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 81 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEM---RLMMNQLEEDLVSARRRSDLYESELRESRLAAE-EFKRK 156
Cdd:TIGR00606 294 KVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLnkeRRLLNQEKTELLVEQGRLQLQADRHQEHIRARDsLIQSL 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 157 ATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLK-----IQELQEKLEKAVKASTE----ATELLQNIRQAKERAEREL 227
Cdd:TIGR00606 374 ATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKtaaqlCADLQSKERLKQEQADEirdeKKGLGRTIELKKEILEKKQ 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 228 EKLQNRE---DSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQI---QQMADKILELEEKHREAQV 301
Cdd:TIGR00606 454 EELKFVIkelQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdldRKLRKLDQEMEQLNHHTTT 533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 302 SAQHLEVHLKQ----------KEQHYEEKIKVLD-------------------NQIKKDLAD-------KETLENMMQRH 345
Cdd:TIGR00606 534 RTQMEMLTKDKmdkdeqirkiKSRHSDELTSLLGyfpnkkqledwlhskskeiNQTRDRLAKlnkelasLEQNKNHINNE 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 346 EEEAHEKGKILSE---QKAMINAMDSKIRSLEQRIVELSE-----ANKLAANSSLFTQRNMKAQ---------------- 401
Cdd:TIGR00606 614 LESKEEQLSSYEDklfDVCGSQDEESDLERLKEEIEKSSKqramlAGATAVYSQFITQLTDENQsccpvcqrvfqteael 693
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 402 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVslehEEQKLELKRQLTELQLSLQE 481
Cdd:TIGR00606 694 QEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPEL----RNKLQKVNRDIQRLKNDIEE 769
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 482 RESQLTALqaaraalesqlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFdalrnsctvitdlEEQLNQLTEDNAELNN 561
Cdd:TIGR00606 770 QETLLGTI------------MPEEESAKVCLTDVTIMERFQMELKDVERKI-------------AQQAAKLQGSDLDRTV 824
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 562 QNfyLSKQLDEASGANDEIVQlrsEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEA 641
Cdd:TIGR00606 825 QQ--VNQEKQEKQHELDTVVS---KIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQS 899
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 642 WRSVLGDEKSQ-------FECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES-- 712
Cdd:TIGR00606 900 LIREIKDAKEQdspletfLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETel 979
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 713 --LSDKLNDLEKKHAMLEMNARSLQQKLETEReLKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-ALDRADLLKTERSD 789
Cdd:TIGR00606 980 ntVNAQLEECEKHQEKINEDMRLMRQDIDTQK-IQERWLQDNLTLRKRENELKEVEEELKQHLKEmGQMQVLQMKQEHQK 1058
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 767972910 790 LEYQLENIQvlysHEKVKMEGTISQQTKLIDFLQAKMDQP 829
Cdd:TIGR00606 1059 LEENIDLIK----RNHVLALGRQKGYEKEIKHFKKELREP 1094
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
215-799 |
5.25e-09 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 61.39 E-value: 5.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 215 NIRQAKERAERELEKLQNREDSsEGIRKKLVEAEERRHSLENKVKRLETMERRenrLKDDIQTKSQQIQQMADKILELEE 294
Cdd:pfam12128 215 KSRLNRQQVEHWIRDIQAIAGI-MKIRPEFTKLQQEFNTLESAELRLSHLHFG---YKSDETLIASRQEERQETSAELNQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 295 KHREaqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINamdskirsle 374
Cdd:pfam12128 291 LLRT-------LDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQ---------- 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 375 qrivelSEANKLAANSSLFTQRNMKAQEEMisELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 454
Cdd:pfam12128 354 ------SELENLEERLKALTGKHQDVTAKY--NRRRSKIKEQNNR-DIAGIKDKLAKIREARDRQLAVAEDDLQALESEL 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 455 REvslEHEEQKLELKRQLTELQLSLQERESQLTALQAaraalESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ---RK 531
Cdd:pfam12128 425 RE---QLEAGKLEFNEEEYRLKSRLGELKLRLNQATA-----TPELLLQLENFDERIERAREEQEAANAEVERLQselRQ 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 532 FDALRNSCTVITDLEEQ-LNQLTEDNAELNNQNF--------YLSKqldEASGANDEIVQLRSEvDHLRREITEREMQLT 602
Cdd:pfam12128 497 ARKRRDQASEALRQASRrLEERQSALDELELQLFpqagtllhFLRK---EAPDWEQSIGKVISP-ELLHRTDLDPEVWDG 572
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 603 SQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRIT 679
Cdd:pfam12128 573 SVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALK 649
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 680 ESRQVVELAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLE 750
Cdd:pfam12128 650 NARLDLRRLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDA 729
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 751 EQAKLQQQMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 799
Cdd:pfam12128 730 QLALLKAAIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
217-909 |
7.15e-09 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 60.75 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 217 RQAKERAE--RELEKLQNREDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQqiqqmadkILELEE 294
Cdd:TIGR00618 160 AKSKEKKEllMNLFPLDQYTQLALMEFAKKKSLHGKAELLT---LRSQLLTLCTPCMPDTYHERKQ--------VLEKEL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 295 KH-REAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKETLENMMQRHE------EEAHEKGKILSEQKAMINaMD 367
Cdd:TIGR00618 229 KHlREALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEetqeriNRARKAAPLAAHIKAVTQ-IE 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 368 SKIRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKNR 446
Cdd:TIGR00618 307 QQAQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQH 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 447 LLELETRLREVSLEHEEQKLELKRQLTElqlSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiQALTAHRD 526
Cdd:TIGR00618 376 TLTQHIHTLQQQKTTLTQKLQSLCKELD---ILQREQATIDTRTSAFRDLQGQLAHAKKQ------------QELQQRYA 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 527 EIQRKFdalrnsctvitdLEEQLNQLTEDNAELNNqnfylskqldeasgandeivqlrsevdhLRREITEREMQLTSQKQ 606
Cdd:TIGR00618 441 ELCAAA------------ITCTAQCEKLEKIHLQE----------------------------SAQSLKEREQQLQTKEQ 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 607 TMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVRELQRMLDTEKQSRARAD---QRITESRQ 683
Cdd:TIGR00618 481 IHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR-QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYhqlTSERKQRA 559
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 684 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 763
Cdd:TIGR00618 560 SLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQ 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 764 nhifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR---- 839
Cdd:TIGR00618 637 -----CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtll 706
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 840 RKEDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 909
Cdd:TIGR00618 707 RELETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
10-379 |
1.35e-08 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 60.05 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARmevsqeddka 89
Cdd:PRK02224 370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTAR---------- 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 90 lqllHDIREQSRKL---------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAEEFKRKATEC 160
Cdd:PRK02224 440 ----ERVEEAEALLeagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AEDLVEAEDRI 511
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 161 QHKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLE----KAVKASTEATELLQNIRQAKERA---ERELEKLQNR 233
Cdd:PRK02224 512 ERLEERREDLEE----LIAERRETIEEKRERAEELRERAAeleaEAEEKREAAAEAEEEAEEAREEVaelNSKLAELKER 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 EDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILE--LEEKHREAQVSAQHLEvHLK 311
Cdd:PRK02224 588 IESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEarIEEAREDKERAEEYLE-QVE 666
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 312 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE--EEAHEKGKILSEQKAMINAMDSKIRS-LEQRIVE 379
Cdd:PRK02224 667 EKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELESMYGDLRAeLRQRNVE 737
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
188-436 |
1.64e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 58.62 E-value: 1.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 188 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQnredssegirKKLVEAEERRHSLEnkvKRLETMERR 267
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE----------RRIAALARRIRALE---QELAALEAE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 268 ENRLKDDIQTKSQQIQQMADkilELEEKHREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKETLENMMQRHEE 347
Cdd:COG4942 85 LAELEKEIAELRAELEAQKE---ELAELLRALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 348 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 427
Cdd:COG4942 147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223
|
....*....
gi 767972910 428 KLEEQLEKI 436
Cdd:COG4942 224 ELEALIARL 232
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
429-876 |
2.24e-08 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 59.36 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 429 LEEQLEKISHQdhsdknrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 501
Cdd:pfam15921 76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 502 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 551
Cdd:pfam15921 149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 552 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLT-------SQKQTMEALKTTCTMLEEQV 622
Cdd:pfam15921 229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITgltekasSARSQANSIQSQLEIIQEQA 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 623 MDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKEHK 693
Cdd:pfam15921 309 RNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADLHK 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 694 AEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLTQG 772
Cdd:pfam15921 389 RE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAIQG 455
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 773 LQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQVPL 852
Cdd:pfam15921 456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRVDL 528
|
490 500
....*....|....*....|....*.
gi 767972910 853 QYNELK-LALEKEKARCAELE-EALQ 876
Cdd:pfam15921 529 KLQELQhLKNEGDHLRNVQTEcEALK 554
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
386-638 |
3.06e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.85 E-value: 3.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 386 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVslehEEQK 465
Cdd:COG4942 10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL----EAEL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 466 LELKRQLTELQLSLQEResqltalqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDL 545
Cdd:COG4942 86 AELEKEIAELRAELEAQ----------KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPAR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 546 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDL 625
Cdd:COG4942 149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
|
250
....*....|...
gi 767972910 626 EALNDELLEKERQ 638
Cdd:COG4942 226 EALIARLEAEAAA 238
|
|
| C1_KSR |
cd20812 |
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ... |
957-1008 |
3.30e-08 |
|
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410362 Cd Length: 48 Bit Score: 51.17 E-value: 3.30e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 957 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 1008
Cdd:cd20812 1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
88-832 |
4.82e-08 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 58.13 E-value: 4.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKATECQ 161
Cdd:TIGR00606 186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 162 HKLLKAKDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA--------ERELEKLqNR 233
Cdd:TIGR00606 259 HNLSKIMKLDN----EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREkerelvdcQRELEKL-NK 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 EDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKH--------REAQVSAQH 305
Cdd:TIGR00606 334 ERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIKNFHtlvierqeDEAKTAAQL 413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 306 LEvHLKQKEQHYEEKIKVLDNQIKkdlADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANK 385
Cdd:TIGR00606 414 CA-DLQSKERLKQEQADEIRDEKK---GLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSK 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 386 LAANSSLFTqrnmkaqeemiseLRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLL------ELETRLREVSL 459
Cdd:TIGR00606 490 AEKNSLTET-------------LKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmDKDEQIRKIKS 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 460 EHEEqklELKRQLTELQLSLQeRESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC 539
Cdd:TIGR00606 557 RHSD---ELTSLLGYFPNKKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVC 632
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 540 TViTDLEEQLNQLTEDNAELNNQNFYLSKqldeASGANDEIVQLRSEVDHLRREITEREMQltSQKQTMEALKTTCTMLE 619
Cdd:TIGR00606 633 GS-QDEESDLERLKEEIEKSSKQRAMLAG----ATAVYSQFITQLTDENQSCCPVCQRVFQ--TEAELQEFISDLQSKLR 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 620 EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLD-TEKQSRARADQRITESRQVVELAV---KEHKAE 695
Cdd:TIGR00606 706 LAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNkLQKVNRDIQRLKNDIEEQETLLGTimpEEESAK 785
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 696 IL--------ALQQALKEQKLKAESLSDKLN--DLEKKHAMLEMNARSLQQKLET---ERELKQRLLEEQAKLQQQMDLQ 762
Cdd:TIGR00606 786 VCltdvtimeRFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDTvvsKIELNRKLIQDQQEQIQHLKSK 865
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 763 KNHIFRLTQGLQEALDRADLLKTErsdLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKK 832
Cdd:TIGR00606 866 TNELKSEKLQIGTNLQRRQQFEEQ---LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSK 932
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
185-884 |
7.21e-08 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 57.52 E-value: 7.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 185 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 264
Cdd:pfam10174 69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 265 ERRENRLKDDIQTKSQQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 331
Cdd:pfam10174 143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 332 LADKETLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 410
Cdd:pfam10174 209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 411 QKFYletqagkleaqnrkleeqlekishQDHSDKnrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 490
Cdd:pfam10174 277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 491 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 563
Cdd:pfam10174 310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 564 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERQWEAWR 643
Cdd:pfam10174 383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE---EALSEKERIIERLK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 644 svlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA--------- 710
Cdd:pfam10174 457 -----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKSleiaveqkk 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 711 ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAldradllKTER 787
Cdd:pfam10174 531 EECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-------ENEK 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 788 SDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELKLALEkekar 867
Cdd:pfam10174 596 NDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQLQLE----- 658
|
730
....*....|....*..
gi 767972910 868 caELEEALQKTRIELRS 884
Cdd:pfam10174 659 --ELMGALEKTRQELDA 673
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
317-888 |
7.28e-08 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 57.38 E-value: 7.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 317 YEEKIKVLDNQIKKDLADKETLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 396
Cdd:PRK03918 160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 397 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRLLELETRLREV-SLEHEEQK-LELKRQLTE 474
Cdd:PRK03918 232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 475 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 554
Cdd:PRK03918 305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 555 DNAELNNQNF-YLSKQLDEASGANDEIvqlRSEVDHLRREITEREMQLTSQKQTMEALKT------TCTMLEEQVMDLEA 627
Cdd:PRK03918 377 LKKRLTGLTPeKLEKELEELEKAKEEI---EEEISKITARIGELKKEIKELKKAIEELKKakgkcpVCGRELTEEHRKEL 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 628 LNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEilalqqALKEQK 707
Cdd:PRK03918 454 LEEYTAELKRI-EKELKEIEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLE------ELEKKA 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 708 LKAESLSDKLNDLEKKhamlemnARSLQQKLETERELKQRLLEEQAKLQQqmdlqknhifrltqglqealdradlLKTER 787
Cdd:PRK03918 525 EEYEKLKEKLIKLKGE-------IKSLKKELEKLEELKKKLAELEKKLDE-------------------------LEEEL 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 788 SDLEYQLENIQVLYSHEkvkMEGTISQQTKLID-FLQAKmdqPAKKKKglfsRRKEDpalptqvplqynelklALEKEKA 866
Cdd:PRK03918 573 AELLKELEELGFESVEE---LEERLKELEPFYNeYLELK---DAEKEL----EREEK----------------ELKKLEE 626
|
570 580
....*....|....*....|..
gi 767972910 867 RCAELEEALQKTRIELRSAREE 888
Cdd:PRK03918 627 ELDKAFEELAETEKRLEELRKE 648
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
273-503 |
8.18e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.31 E-value: 8.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 273 DDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKETLENMMQRHEEEAHEK 352
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 353 GKILSEQKAMinamdskirsLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 432
Cdd:COG4942 96 RAELEAQKEE----------LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 433 LEKISHQdhsdKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 503
Cdd:COG4942 166 RAELEAE----RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
|
|
| PH |
pfam00169 |
PH domain; PH stands for pleckstrin homology. |
1040-1159 |
8.47e-08 |
|
PH domain; PH stands for pleckstrin homology.
Pssm-ID: 459697 [Multi-domain] Cd Length: 105 Bit Score: 51.79 E-value: 8.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1040 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1119
Cdd:pfam00169 1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 767972910 1120 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1159
Cdd:pfam00169 69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2-348 |
8.69e-08 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 57.08 E-value: 8.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHR---------RVSEVEAVLSQKEV---ELKASETQRSLLEQDLATYITECS 69
Cdd:COG4717 94 QEELEELEEELEELEAELEELREELEKLEKllqllplyqELEALEAELAELPErleELEERLEELRELEEELEELEAELA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 70 SLKRSLEQARMEVSQEDDKALQ-LLHDIREQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRES 146
Cdd:COG4717 174 ELQEELEELLEQLSLATEEELQdLAEELEELQQRLAELEEELEEAQEELEELEeeLEQLENELEAAALEERLKEARLLLL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 147 RLAA---------------------------------EEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQ 193
Cdd:COG4717 254 IAAAllallglggsllsliltiagvlflvlgllallfLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPD 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 194 ELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE-------DSSEGIRKKLvEAEERRHSLENKVKRLETMER 266
Cdd:COG4717 334 LSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAllaeagvEDEEELRAAL-EQAEEYQELKEELEELEEQLE 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 267 REN-------------RLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLE-----VHLKQKEQHYEEKIKVLDNQI 328
Cdd:COG4717 413 ELLgeleellealdeeELEEELEELEEELEELEEELEELREELAELEAELEQLEedgelAELLQELEELKAELRELAEEW 492
|
410 420
....*....|....*....|
gi 767972910 329 KKDLADKETLENMMQRHEEE 348
Cdd:COG4717 493 AALKLALELLEEAREEYREE 512
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
310-504 |
8.78e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.31 E-value: 8.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 310 LKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS---EANKL 386
Cdd:COG4942 25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaelEAQKE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 387 AANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKIshqdHSDKNRLLELETRLREVSLEHEEQK 465
Cdd:COG4942 105 ELAELLRALYRLGRQPPLALLLSPEDFLdAVRRLQYLKYLAPARREQAEEL----RADLAELAALRAELEAERAELEALL 180
|
170 180 190
....*....|....*....|....*....|....*....
gi 767972910 466 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 504
Cdd:COG4942 181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
526-805 |
9.47e-08 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 57.23 E-value: 9.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 526 DEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQK 605
Cdd:COG4913 228 DALVEHFDDLERAHEALEDAREQIELLEP-----------IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL--LE 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 606 QTMEALKTTCTMLEEQVMDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQV 684
Cdd:COG4913 295 AELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 685 VELAVKEHKAEILALQQALKEQKLKAESLSDKlndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKN 764
Cdd:COG4913 371 LGLPLPASAEEFAALRAEAAALLEALEEELEA-----------------LEEALAEAEAALRDLRRELRELEAEIASLER 433
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 767972910 765 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEK 805
Cdd:COG4913 434 RKSNIPARLLALRDAlAEALGLDEAELPFVGELIEVRPEEER 475
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
528-760 |
9.80e-08 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 56.95 E-value: 9.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 528 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 601
Cdd:COG3206 166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 602 TSQKQTMEALKTTCTMLEEQVMdLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITES 681
Cdd:COG3206 243 AALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQQEAQRILAS 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 682 RQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE--EQAKLQQQM 759
Cdd:COG3206 318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrlEEARLAEAL 383
|
.
gi 767972910 760 D 760
Cdd:COG3206 384 T 384
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
679-890 |
1.12e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 55.93 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 679 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 758
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 759 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 820
Cdd:COG4942 99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 821 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 890
Cdd:COG4942 175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
396-791 |
1.39e-07 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 56.31 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 396 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKNRLLELETRLREVSlEHEEQKLELKRQLT 473
Cdd:COG4717 71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 474 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 553
Cdd:COG4717 150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 554 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQTM 608
Cdd:COG4717 227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 609 EALKTTCTMLEEQV---------MDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 673
Cdd:COG4717 307 LQALPALEELEEEEleellaalgLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 674 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 753
Cdd:COG4717 387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456
|
410 420 430
....*....|....*....|....*....|....*...
gi 767972910 754 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 791
Cdd:COG4717 457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
422-879 |
1.41e-07 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 55.84 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 422 LEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALESQLR 501
Cdd:pfam19220 25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGK----LRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 502 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 581
Cdd:pfam19220 101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 582 QLRSEVDHLRREITEREMQLTSQKQTMEALkttctmLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQ 661
Cdd:pfam19220 153 KALQRAEGELATARERLALLEQENRRLQAL------SEEQAAELAELTRRLAELETQLDATRA-----------RLRALE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 662 RMLDTEKQSRARADQRItesrqvvELAVKEHKAEILALqqalkeqKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETE 741
Cdd:pfam19220 216 GQLAAEQAERERAEAQL-------EEAVEAHRAERASL-------RMKLEALTARAAATEQ---LLAEARNQLRDRDEAI 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 742 RELKQRLLE---EQAKLQQQMDLQKNHIFRLTQGLQEaLDRADLLKTERSDLEyqlenIQVLYSHEKvkmegTISQQTKL 818
Cdd:pfam19220 279 RAAERRLKEasiERDTLERRLAGLEADLERRTQQFQE-MQRARAELEERAEML-----TKALAAKDA-----ALERAEER 347
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 819 IDFLQAKMDQPAKKkkglfsRRKEDPALPTQVplqyNELKLALEKEKARCAELEEALQKTR 879
Cdd:pfam19220 348 IASLSDRIAELTKR------FEVERAALEQAN----RRLKEELQRERAERALAQGALEIAR 398
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
191-354 |
1.61e-07 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 55.94 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 191 KIQELQEKLEKAVK-ASTEATELLQN-IRQAKERAERELEKLqnrEDSSEGIRKKLVEAEERRHSLENKV-KRLETMERR 267
Cdd:PRK12704 32 KIKEAEEEAKRILEeAKKEAEAIKKEaLLEAKEEIHKLRNEF---EKELRERRNELQKLEKRLLQKEENLdRKLELLEKR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 268 ENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLAdketleNMMQRHE 346
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKKEEELEELIEEQL---QELERISGlTAEEAKEILLEKVEEEARHEAA------VLIKEIE 179
|
....*...
gi 767972910 347 EEAHEKGK 354
Cdd:PRK12704 180 EEAKEEAD 187
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
453-779 |
2.02e-07 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 56.11 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 453 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 532
Cdd:COG3096 282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 533 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 612
Cdd:COG3096 354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALE 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 613 TTCTMLEEQVMDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA--RADQRITE 680
Cdd:COG3096 424 KARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAwqTARELLRR 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 681 SRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETERELKQRLLEE 751
Cdd:COG3096 504 YRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVEQ 579
|
330 340 350
....*....|....*....|....*....|....
gi 767972910 752 QAKLQQQMDLQKNHIFRLTQ------GLQEALDR 779
Cdd:COG3096 580 RSELRQQLEQLRARIKELAArapawlAAQDALER 613
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
573-835 |
2.65e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 54.77 E-value: 2.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 573 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTtctmleeqvmDLEALNDELLEKERQweawrsvlgdeksq 652
Cdd:COG4942 15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK----------QLAALERRIAALARR-------------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 653 fecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 732
Cdd:COG4942 71 ----IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 733 SLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTI 812
Cdd:COG4942 147 ARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222
|
250 260
....*....|....*....|...
gi 767972910 813 SQQTKLIDFLQAKMDQPAKKKKG 835
Cdd:COG4942 223 EELEALIARLEAEAAAAAERTPA 245
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
327-885 |
2.77e-07 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 55.52 E-value: 2.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 327 QIKKDLADKEtLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 404
Cdd:pfam05557 13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 405 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 481
Cdd:pfam05557 75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 482 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 556
Cdd:pfam05557 151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 557 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVMDLEALNDELL 633
Cdd:pfam05557 224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQQREIVLKEENSSLT 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 634 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALKEQKLKA 710
Cdd:pfam05557 304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSPQLLERI 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 711 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDRADLLKT 785
Cdd:pfam05557 383 EEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLRE 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 786 ERSDLEYQLE--NIQVLYSHEKVKM-------EGTISQQTK-LIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL--- 852
Cdd:pfam05557 463 QKNELEMELErrCLQGDYDPKKTKVlhlsmnpAAEAYQQRKnQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTmnf 542
|
570 580 590
....*....|....*....|....*....|....
gi 767972910 853 -QYNELKLALEKEKARCAELEEALQKTRIELRSA 885
Cdd:pfam05557 543 kEVLDLRKELESAELKNQRLKEVFQAKIQEFRDV 576
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
140-759 |
3.32e-07 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 55.61 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 140 ESELRES---RLAAEEFKRKATECQ-HKLLKAKDQGKPEVGEyaKLEKINAEQQLKIQELQEKL---EKAVKASTEATEL 212
Cdd:pfam12128 249 EFNTLESaelRLSHLHFGYKSDETLiASRQEERQETSAELNQ--LLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEA 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 213 LQNirQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLE-TMERRENRLKDDIQTKSQQIQQMADKILE 291
Cdd:pfam12128 327 LED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIRE 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 292 LEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 370
Cdd:pfam12128 405 ARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIERAREEQEAAN 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 371 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKlEEQLEKISHQDHSDKNRLL-- 448
Cdd:pfam12128 485 AEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrt 563
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 449 ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERESQL-TALQAAR---AALESQLRQAKTELEETTAEAEE 516
Cdd:pfam12128 564 DLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERLDKAeEALQSARekqAAAEEQLVQANGELEKASREETF 643
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 517 EIQALTAHRDEIQRKFDALRNSCTVITD--------LEEQLNQL-TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV 587
Cdd:pfam12128 644 ARTALKNARLDLRRLFDEKQSEKDKKNKalaerkdsANERLNSLeAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV 723
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 588 dhlrreITEREMQLTSQKQTMEALKTTctmLEEQVMDLEALNDELLEKerqweawRSVLGDEKSQFECRVRELQRMLDTE 667
Cdd:pfam12128 724 ------EGALDAQLALLKAAIAARRSG---AKAELKALETWYKRDLAS-------LGVDPDVIAKLKREIRTLERKIERI 787
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 668 KQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKAESlsdKLNDLEKKHAMLEMNARSLQQKLETER----E 743
Cdd:pfam12128 788 AVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNIER---AISELQQQLARLIADTKLRRAKLEMERkaseK 853
|
650
....*....|....*.
gi 767972910 744 LKQRLLEEQAKLQQQM 759
Cdd:pfam12128 854 QQVRLSENLRGLRCEM 869
|
|
| PH |
smart00233 |
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ... |
1040-1159 |
3.38e-07 |
|
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.
Pssm-ID: 214574 [Multi-domain] Cd Length: 102 Bit Score: 50.24 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1040 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1119
Cdd:smart00233 1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 767972910 1120 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1159
Cdd:smart00233 69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
520-889 |
3.77e-07 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 55.05 E-value: 3.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 520 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 599
Cdd:PRK02224 188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 600 QLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS--------- 670
Cdd:PRK02224 266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAaqahneeae 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 671 --RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL 748
Cdd:PRK02224 346 slREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDEL 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 749 LEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshEKVKMEGTIS 813
Cdd:PRK02224 425 REREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----EVEEVEERLE 499
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 814 QQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEA 889
Cdd:PRK02224 500 RAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
177-339 |
3.80e-07 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 53.00 E-value: 3.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 177 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEgirKKLVEAeerrhsleN 256
Cdd:COG1579 18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 257 KVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 336
Cdd:COG1579 87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166
|
...
gi 767972910 337 TLE 339
Cdd:COG1579 167 ELA 169
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
463-725 |
4.32e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 54.00 E-value: 4.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 463 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 542
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 543 tDLEEQLNQLTEDNAELNNQnfylskqldeasgandeIVQLRSEVDHLRREITE--REMQLTSQKQTMEALKTTCTMLE- 619
Cdd:COG4942 73 -ALEQELAALEAELAELEKE-----------------IAELRAELEAQKEELAEllRALYRLGRQPPLALLLSPEDFLDa 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 620 -EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelaVKEHKAEILA 698
Cdd:COG4942 135 vRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL----LARLEKELAE 210
|
250 260
....*....|....*....|....*..
gi 767972910 699 LQQALKEQKLKAESLSDKLNDLEKKHA 725
Cdd:COG4942 211 LAAELAELQQEAEELEALIARLEAEAA 237
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
184-604 |
5.62e-07 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 54.36 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 184 INAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRH----------- 252
Cdd:pfam05557 12 SQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALReqaelnrlkkk 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 253 SLENKVKRLETMERRENRLKDDIQTKSQQI----QQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDNQi 328
Cdd:pfam05557 84 YLEALNKKLNEKESQLADAREVISCLKNELselrRQIQRAELELQSTNSELEELQERLDL-LKAKASEAEQLRQNLEKQ- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 329 KKDLADKE----TLENMMQRHEEEAHEKGKILSEQkAMINAMDSKIRSLEQRIVELSEANKlaaNSSLFTQ--------- 395
Cdd:pfam05557 162 QSSLAEAEqrikELEFEIQSQEQDSEIVKNSKSEL-ARIPELEKELERLREHNKHLNENIE---NKLLLKEevedlkrkl 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 396 -RNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRKLE--------EQLEKISHQD--HSDKNRLLELETR-LREVSLEHE 462
Cdd:pfam05557 238 eREEKYREEAATlELEKEKLEQELQSWVKLAQDTGLNlrspedlsRRIEQLQQREivLKEENSSLTSSARqLEKARRELE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 463 EQKLELKRQLTELQLSLQERESQLTALQ-----------AARAALES-----QLRQAKTELEETTAEAEEEIQALTAHRD 526
Cdd:pfam05557 318 QELAQYLKKIEDLNKKLKRHKALVRRLQrrvllltkerdGYRAILESydkelTMSNYSPQLLERIEEAEDMTQKMQAHNE 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 527 EIQRKFDALRNSCTVITD----LEEQLNQLTEDnaELNNQNFYLSKQLDEASGANDEivqLRSEVDHLRREITEREMQLT 602
Cdd:pfam05557 398 EMEAQLSVAEEELGGYKQqaqtLERELQALRQQ--ESLADPSYSKEEVDSLRRKLET---LELERQRLREQKNELEMELE 472
|
..
gi 767972910 603 SQ 604
Cdd:pfam05557 473 RR 474
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
190-339 |
6.03e-07 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 52.23 E-value: 6.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 190 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLET--MERR 267
Cdd:COG1579 10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 268 ENR----LKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE 339
Cdd:COG1579 87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
618-911 |
6.12e-07 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 54.68 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 618 LEEQVMDLEALNDELLEKERQWEawrsvlgdeksqfecrvrELQRmldtekqsRARADQRITESRQvvelAVKEHKAEIL 697
Cdd:TIGR02168 181 LERTRENLDRLEDILNELERQLK------------------SLER--------QAEKAERYKELKA----ELRELELALL 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 698 ALQqaLKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL 777
Cdd:TIGR02168 231 VLR--LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILR 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 778 DRADLLKTERSDLEYQLENIQ---VLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQY 854
Cdd:TIGR02168 309 ERLANLERQLEELEAQLEELEsklDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV 388
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 855 NELKLALEKEKARCAELEEalQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIA 911
Cdd:TIGR02168 389 AQLELQIASLNNEIERLEA--RLERLEDRRERLQQEIEELLKKLEEAELKELQAELE 443
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
217-598 |
7.53e-07 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 54.19 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 217 RQAKERAERELEKLQNREDSSeGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------QQIQ 283
Cdd:PRK04863 276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 284 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKETLENMMQRHEEEAHEKGKIL 356
Cdd:PRK04863 352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 357 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 431
Cdd:PRK04863 424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 432 QLEKISHQDhsdkNRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 508
Cdd:PRK04863 504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 509 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 588
Cdd:PRK04863 579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658
|
410
....*....|
gi 767972910 589 HLRREITERE 598
Cdd:PRK04863 659 EEIERLSQPG 668
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2-585 |
7.55e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 54.41 E-value: 7.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKelQDSQDKCHKMEQEMTRLHRRVSEVEAV-------LSQKEVELKASETQRSLLEQDLATYITECSSLKRS 74
Cdd:pfam01576 392 ELRTLQQAK--QDSEHKRKKLEGQLQELQARLSESERQraelaekLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 75 LEQARMEVSQEDDKALQLLHDIR---EQSRKLQEIKEQEYQA--------------------QVEEMRLMMNQLEEDLVS 131
Cdd:pfam01576 470 LQDTQELLQEETRQKLNLSTRLRqleDERNSLQEQLEEEEEAkrnverqlstlqaqlsdmkkKLEEDAGTLEALEEGKKR 549
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 132 ARRRSDLYESELRESRLAAEEFKRKATECQHKL---LKAKDQGKPEVGEYAKLEK----INAEQQLKIQELQEKLEKAVK 204
Cdd:pfam01576 550 LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELddlLVDLDHQRQLVSNLEKKQKkfdqMLAEEKAISARYAEERDRAEA 629
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 205 ASTEA-------TELLQNIRQAKERAER-------ELEKLQNREDSS------------------EGIRKKLVEAEERRH 252
Cdd:pfam01576 630 EAREKetralslARALEEALEAKEELERtnkqlraEMEDLVSSKDDVgknvhelerskraleqqvEEMKTQLEELEDELQ 709
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 253 SLENKVKRLE-TMERRENRLKDDIQTKSQQ--------IQQMADKILELEE--KHREAQVSA-QHLEVHLKQKEQHYEEK 320
Cdd:pfam01576 710 ATEDAKLRLEvNMQALKAQFERDLQARDEQgeekrrqlVKQVRELEAELEDerKQRAQAVAAkKKLELDLKELEAQIDAA 789
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 321 IKVLDNQIKKdLADKETLENMMQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNM 398
Cdd:pfam01576 790 NKGREEAVKQ-LKKLQAQMKDLQRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQ 861
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 399 KaQEEMISELRQQ---KFYLETQAGKLEAQNRKLEEQLEKISHQDH--SDKNRLLELETRLREVSLEHEE---QKLE--- 467
Cdd:pfam01576 862 E-RDELADEIASGasgKSALQDEKRRLEARIAQLEEELEEEQSNTEllNDRLRKSTLQVEQLTTELAAERstsQKSEsar 940
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 468 --LKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEIQ 529
Cdd:pfam01576 941 qqLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHADQ 1020
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 530 RKfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 585
Cdd:pfam01576 1021 YK-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
333-558 |
1.02e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.84 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 333 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQK 412
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA-------LEQELAALEAELAELEKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 413 FYLETQAGKLEAQNRKLEEQLEKISHQDH-------SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ 485
Cdd:COG4942 93 AELRAELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972910 486 LTALQAARAALESQlrqaKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 558
Cdd:COG4942 173 RAELEALLAELEEE----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
542-764 |
1.12e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.84 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 542 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 621
Cdd:COG4942 22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 622 vmdLEALNDELleKERQWEAWRS---------VLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVKEH 692
Cdd:COG4942 99 ---LEAQKEEL--AELLRALYRLgrqpplallLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRAEL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972910 693 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 764
Cdd:COG4942 170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
344-772 |
1.18e-06 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 53.80 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 344 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 418
Cdd:COG3096 275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 419 AGKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 498
Cdd:COG3096 353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 499 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 575
Cdd:COG3096 424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 576 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEkerqWEAWRSV 645
Cdd:COG3096 493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE----LEAQLEE 568
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 646 LGDEKSQFECRVRELQRmldTEKQSRARADqritesrqvvELAVKEhkAEILALQQALkeqklkaESLSDKLND-LEKKH 724
Cdd:COG3096 569 LEEQAAEAVEQRSELRQ---QLEQLRARIK----------ELAARA--PAWLAAQDAL-------ERLREQSGEaLADSQ 626
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 725 AMleMNARslQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 772
Cdd:COG3096 627 EV--TAAM--QQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
50-842 |
1.38e-06 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 53.52 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 50 SETQRSLLE--QDLAT------YITECSSLKRSLEQAR----------------------MEVSQEDDKALQLLHDIREQ 99
Cdd:TIGR01612 900 NEINKSIEEeyQNINTlkkvdeYIKICENTKESIEKFHnkqnilkeilnknidtikesnlIEKSYKDKFDNTLIDKINEL 979
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 100 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLvSARRRSDLYEsELRESRLAAEEFKRKATECQhkllkaKDQGKPEVGEYA 179
Cdd:TIGR01612 980 DKAFKDASLNDYEAKNNELIKYFNDLKANL-GKNKENMLYH-QFDEKEKATNDIEQKIEDAN------KNIPNIEIAIHT 1051
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 180 KLEKINAEQQLKIQELQEKLEKAV--KASTEATellqNIRQAKERAereleKLQNREDSSEgirkklveaeerrhslENK 257
Cdd:TIGR01612 1052 SIYNIIDEIEKEIGKNIELLNKEIleEAEINIT----NFNEIKEKL-----KHYNFDDFGK----------------EEN 1106
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 258 VKRLETMerreNRLKDDIQTKSQQIQQmadKILELEEkhreaqvsaqhlevhLKQKEQHYEEKIKVLDNQIkKDLADK-- 335
Cdd:TIGR01612 1107 IKYADEI----NKIKDDIKNLDQKIDH---HIKALEE---------------IKKKSENYIDEIKAQINDL-EDVADKai 1163
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 336 -----ETLENMMQRHEEEAHEKGKILSEQKAMINAMdSKIR----SLEQ-RIVELSEANKLAA----------NSSLFTQ 395
Cdd:TIGR01612 1164 snddpEEIEKKIENIVTKIDKKKNIYDEIKKLLNEI-AEIEkdktSLEEvKGINLSYGKNLGKlflekideekKKSEHMI 1242
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 396 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEeqLEKISHQDHSDKNrlleletrlrEVSLEHEEQKLELKrqltEL 475
Cdd:TIGR01612 1243 KAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEME--TFNISHDDDKDHH----------IISKKHDENISDIR----EK 1306
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 476 QLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiqaLTAHRDEIQRKFDALR--NSCTVITDLEEQLNQLT 553
Cdd:TIGR01612 1307 SLKIIEDFSEESDINDIKKELQKNLLDAQKHNSD-----------INLYLNEIANIYNILKlnKIKKIIDEVKEYTKEIE 1375
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 554 EDNAELNNQ---NFYLSKQLDEASGANDEIVQLRS-----EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMdL 625
Cdd:TIGR01612 1376 ENNKNIKDEldkSEKLIKKIKDDINLEECKSKIEStlddkDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVL-L 1454
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 626 EALNDELLEKERQWeawrsVLGDEK----SQFECRVRELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQ 701
Cdd:TIGR01612 1455 LFKNIEMADNKSQH-----ILKIKKdnatNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLN 1528
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 702 ALKEQKLK---AESLSDK---LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQ 771
Cdd:TIGR01612 1529 KYSALAIKnkfAKTKKDSeiiIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LE 1603
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972910 772 GLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGT-ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKE 842
Cdd:TIGR01612 1604 NFENKFLKISDIKKKINDCLKETESIEKKISSFSIDSQDTeLKENGDNLNSLQEFLESLKDQKKNIEDKKKE 1675
|
|
| C1_1 |
pfam00130 |
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ... |
954-1009 |
1.94e-06 |
|
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.
Pssm-ID: 395079 Cd Length: 53 Bit Score: 46.28 E-value: 1.94e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 954 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1009
Cdd:pfam00130 1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
519-739 |
2.06e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.07 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 519 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREI 594
Cdd:COG4942 16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALarriRALEQELAALEAELAELEKEI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 595 TEREMQLTSQKQTM-EALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRar 673
Cdd:COG4942 93 AELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAALR-- 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 674 adQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 739
Cdd:COG4942 167 --AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
670-947 |
2.31e-06 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 51.75 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 670 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 747
Cdd:COG3883 10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 748 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 824
Cdd:COG3883 86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 825 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 904
Cdd:COG3883 141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 767972910 905 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 947
Cdd:COG3883 221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
269-798 |
2.39e-06 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 52.35 E-value: 2.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 269 NRLKDDiqtKSQQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE 348
Cdd:PRK02224 179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 349 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 428
Cdd:PRK02224 250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 429 LEEQLEKISHQDHSDKNRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 508
Cdd:PRK02224 295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 509 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 586
Cdd:PRK02224 367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 587 VDHLRreitEREMQLTSQKQTmealkttctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 666
Cdd:PRK02224 421 RDELR----EREAELEATLRT----------ARERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELED 486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 667 EKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER 742
Cdd:PRK02224 487 LEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAE 564
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 743 ELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 798
Cdd:PRK02224 565 EEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
2-316 |
2.51e-06 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 52.52 E-value: 2.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVseveavlsqkevelKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam10174 393 ERKINVLQKKIENLQEQLRDKDKQLAGLKERV--------------KSLQTDSSNTDTALTTLEEALSEKERIIERLKEQ 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQEDDKALQLLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQ 161
Cdd:pfam10174 459 REREDRERLEELESLKKENKDLKE-KVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLE 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 162 HKLLKAKDQgkpEVGEYAKLEKINAEQQLKiQELQEKLEKAVKASTEATELLQNIRQA------KERAERELEKLQNR-- 233
Cdd:pfam10174 538 NQLKKAHNA---EEAVRTNPEINDRIRLLE-QEVARYKEESGKAQAEVERLLGILREVenekndKDKKIAELESLTLRqm 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 -EDSSEGIRKKLVEAEERRHSLEnkvkRLETMERRENRLKDDiqtksQQIQQMADKILELEEKHREAQVSAQHL---EVH 309
Cdd:pfam10174 614 kEQNKKVANIKHGQQEMKKKGAQ----LLEEARRREDNLADN-----SQQLQLEELMGALEKTRQELDATKARLsstQQS 684
|
....*..
gi 767972910 310 LKQKEQH 316
Cdd:pfam10174 685 LAEKDGH 691
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
395-610 |
2.54e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 51.69 E-value: 2.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 395 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE 474
Cdd:COG4942 33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 475 LQLSLQERE-----SQLTALQAARAA--LESQLRQAKTELEETTaeaeEEIQALTAHRDEIQRKFDALRnscTVITDLEE 547
Cdd:COG4942 113 LYRLGRQPPlalllSPEDFLDAVRRLqyLKYLAPARREQAEELR----ADLAELAALRAELEAERAELE---ALLAELEE 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972910 548 QLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 610
Cdd:COG4942 186 ERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1516-1605 |
4.36e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 51.61 E-value: 4.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1516 ESGTEHHRGPSTSRSSPNKRGPPtyNEHITKRVASSPAP---------------PEGPSH---PREPSTPHRYREGRTEL 1577
Cdd:PTZ00449 527 KEGEEGEHEDSKESDEPKEGGKP--GETKEGEVGKKPGPakehkpskiptlskkPEFPKDpkhPKDPEEPKKPKRPRSAQ 604
|
90 100 110
....*....|....*....|....*....|..
gi 767972910 1578 R--RDKSPGRP--LEREKSPGRMLSTRRERSP 1605
Cdd:PTZ00449 605 RptRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
380-632 |
4.39e-06 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 51.55 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 380 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKNrllELETRLREVSL 459
Cdd:PHA02562 165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 460 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE------------ETTAEAEEEIQALTAHRDE 527
Cdd:PHA02562 231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 528 IQRKFDALRNSctvITDLEEQLNQ-------LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 600
Cdd:PHA02562 311 LQHSLEKLDTA---IDELEEIMDEfneqskkLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDE 387
|
250 260 270
....*....|....*....|....*....|..
gi 767972910 601 LTsqkqtmeALKTTCTMLEEQVMDLEALNDEL 632
Cdd:PHA02562 388 LD-------KIVKTKSELVKEKYHRGIVTDLL 412
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
281-761 |
5.95e-06 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 51.34 E-value: 5.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 281 QIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKETLEnmmqrheeEAHEKGKILSEQK 360
Cdd:PRK10246 434 QIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQEARIKDLEAQR 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 361 AMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrkLEEQLekisH 438
Cdd:PRK10246 498 AQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA----LTKQL----Q 561
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 439 QDHSDKNRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQLTALQAARAA 495
Cdd:PRK10246 562 RDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQIIQYQQQIEQ 641
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 496 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELnnqnfylsKQLDEASg 575
Cdd:PRK10246 642 RQQQLLTALAGYALTLPQEDEEASWLATRQQEAQS----WQQRQNELTALQNRIQQLTPLLETL--------PQSDDLP- 708
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 576 ANDEIVQLrsevDHLrREITEREMQLTSQKQTMEALkttctmleeqvmdlealndELLEKERQWEA---WRSVLgdEKSQ 652
Cdd:PRK10246 709 HSEETVAL----DNW-RQVHEQCLSLHSQLQTLQQQ-------------------DVLEAQRLQKAqaqFDTAL--QASV 762
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 653 FECRVRELQRMLDTEkqsrarADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 732
Cdd:PRK10246 763 FDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQIQQELAQLAQ 836
|
490 500
....*....|....*....|....*....
gi 767972910 733 SLQQKLETERELKQRLLEEQAKLQQQMDL 761
Cdd:PRK10246 837 QLRENTTRQGEIRQQLKQDADNRQQQQAL 865
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
1-485 |
6.87e-06 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 50.89 E-value: 6.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ-KEVELKASETQRSLLEqdlatyitecssLKRSLEQAR 79
Cdd:pfam05557 18 KKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLlEKREAEAEEALREQAE------------LNRLKKKYL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 80 MEVSQEDDKALQLLHDIRE-QSRKLQEIKEQEYQAQVEEMRLMMNQLEedLVSARRRSDLYESELRESrlaaeEFKRKAT 158
Cdd:pfam05557 86 EALNKKLNEKESQLADAREvISCLKNELSELRRQIQRAELELQSTNSE--LEELQERLDLLKAKASEA-----EQLRQNL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 159 ECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQE---KLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED 235
Cdd:pfam05557 159 EKQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELAripELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 236 SSEGIRKKLVEAEERRHSLENKVK---RLETMERRENRLKDDIQTKSQQIQQmadkilelEEKHREAQVSAqhlevhLKQ 312
Cdd:pfam05557 239 REEKYREEAATLELEKEKLEQELQswvKLAQDTGLNLRSPEDLSRRIEQLQQ--------REIVLKEENSS------LTS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 313 KEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEkgkiLSEQKAMInamdSKIRSLEQRIVELSEANKLAANSSL 392
Cdd:pfam05557 305 SARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRR----LQRRVLLL----TKERDGYRAILESYDKELTMSNYSP 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 393 FTQRNMKAQEEMI-------SELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQ-DHSDKNRLLELETRLREVSLEHEEQ 464
Cdd:pfam05557 377 QLLERIEEAEDMTqkmqahnEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQeSLADPSYSKEEVDSLRRKLETLELE 456
|
490 500
....*....|....*....|.
gi 767972910 465 KLELKRQLTELQLSLQERESQ 485
Cdd:pfam05557 457 RQRLREQKNELEMELERRCLQ 477
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
586-892 |
8.72e-06 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 50.61 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 586 EVDHLRREITEREmQLTSQKQTMEALKTTctMLEEQVMDLEALNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLD 665
Cdd:pfam12128 229 DIQAIAGIMKIRP-EFTKLQQEFNTLESA--ELRLSHLHFGYKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRD 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 666 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL- 744
Cdd:pfam12128 305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKi 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 745 KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQA 824
Cdd:pfam12128 385 KEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 825 kmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQKTRIELRSAREEAAHR 892
Cdd:pfam12128 459 ------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQSELRQARKRRDQASEA 507
|
|
| Tropomyosin |
pfam00261 |
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ... |
154-349 |
8.73e-06 |
|
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.
Pssm-ID: 459736 [Multi-domain] Cd Length: 235 Bit Score: 48.87 E-value: 8.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 154 KRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNR 233
Cdd:pfam00261 7 KEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEKAADESERGRKVLENR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 234 ----EDSSEGIRKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVH 309
Cdd:pfam00261 87 alkdEEKMEILEAQLKEAKEIAEEAD---RKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLEAS 163
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 767972910 310 LK---QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEA 349
Cdd:pfam00261 164 EEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
210-555 |
8.76e-06 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 50.07 E-value: 8.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 210 TELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSQQIQQMADK 288
Cdd:pfam19220 37 EAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRDK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 289 ILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDS 368
Cdd:pfam19220 117 TAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELTR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 369 KIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishqd 440
Cdd:pfam19220 196 RLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 441 hsdknrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA 520
Cdd:pfam19220 264 ------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTKA 333
|
330 340 350
....*....|....*....|....*....|....*
gi 767972910 521 LTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 555
Cdd:pfam19220 334 LAAKD-------AALERAEERIASLSDRIAELTKR 361
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
97-797 |
9.27e-06 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 50.59 E-value: 9.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 97 REQSRKLQEIKEQEYQAQVE--EMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 174
Cdd:pfam10174 49 KEEAARISVLKEQYRVTQEEnqHLQLTIQALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEHERQ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 175 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNirqakeraeRELEKLQNREDSSEGIRkkLVEAEERRHSL 254
Cdd:pfam10174 129 AKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQS---------KGLPKKSGEEDWERTRR--IAEAEMQLGHL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 255 EN--------KVKRLETMERRENRLKDDIQTKS-QQIQQMAD-KILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVL 324
Cdd:pfam10174 198 EVlldqkekeNIHLREELHRRNQLQPDPAKTKAlQTVIEMKDtKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQM 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 325 D-------------NQIKKDLADKETLENMMQRHEEEAHEKGkilSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANS 390
Cdd:pfam10174 278 EvykshskfmknkiDQLKQELSKKESELLALQTKLETLTNQN---SDCKQHIEVLKESLTAKEQRAAILqTEVDALRLRL 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 391 SLfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLEEQLEKIshqdhsdkNRLLELETRLREVSLEHEEQKLELKR 470
Cdd:pfam10174 355 EE-KESFLNKKTKQLQDLTEEK---STLAGEIRDLKDMLDVKERKI--------NVLQKKIENLQEQLRDKDKQLAGLKE 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 471 QLTELQLSLQERESQLTALQAARAALEsqlrqakteleettaeaeEEIQALTAHRD-EIQRKFDALRNSCTVITDLEEQL 549
Cdd:pfam10174 423 RVKSLQTDSSNTDTALTTLEEALSEKE------------------RIIERLKEQRErEDRERLEELESLKKENKDLKEKV 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 550 NQLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltsQKQTMEALKTTCTMLEEQVMDLEA-L 628
Cdd:pfam10174 485 SAL---QPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV---------EQKKEECSKLENQLKKAHNAEEAVrT 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 629 NDELLEKERQWEAWRSVLGDE--KSQFEC-RVRELQRMLDTEKQSRaraDQRITEsrqvvelavkehkAEILALQQaLKE 705
Cdd:pfam10174 553 NPEINDRIRLLEQEVARYKEEsgKAQAEVeRLLGILREVENEKNDK---DKKIAE-------------LESLTLRQ-MKE 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 706 QKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQ--RLLEEQAKLQQQMDLQKNHIFRLTQGLQEaldRADLL 783
Cdd:pfam10174 616 QNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQleELMGALEKTRQELDATKARLSSTQQSLAE---KDGHL 692
|
730
....*....|....
gi 767972910 784 KTERSDLEYQLENI 797
Cdd:pfam10174 693 TNLRAERRKQLEEI 706
|
|
| COG4487 |
COG4487 |
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown]; |
91-293 |
9.63e-06 |
|
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
Pssm-ID: 443580 [Multi-domain] Cd Length: 425 Bit Score: 49.94 E-value: 9.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 91 QLLHDIREQSRklqeikeQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL---RESRLAAEEFKRKATECQHKLLKA 167
Cdd:COG4487 18 SLYADIVKQRR-------AEFEKELAERLADAAKREAALELAEAKAKAQLQEQvaeKDAEIAELRARLEAEERKKALAVA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 168 KDQGKpevgEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATEllqnirqAKERAERELEK--LQNREDSSEGIRKKLV 245
Cdd:COG4487 91 EEKEK----ELAALQEALAEKDAKLAELQAKELELLKKERELED-------AKREAELTVEKerDEELDELKEKLKKEEE 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 767972910 246 EAEERRHSLEN--KVKRLETMERRENRLKDDIQtksQQIQQMADKILELE 293
Cdd:COG4487 160 EKQLAEKSLKVaeYEKQLKDMQEQIEELKRKKE---QGSTQLQGEVLELE 206
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
179-534 |
9.65e-06 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 49.90 E-value: 9.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 179 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegirkklvEAEERRHSLENKV 258
Cdd:COG4372 27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 259 KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKETL 338
Cdd:COG4372 94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 339 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 418
Cdd:COG4372 170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 419 AGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 498
Cdd:COG4372 250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 767972910 499 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 534
Cdd:COG4372 330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
|
|
| COG5281 |
COG5281 |
Phage-related minor tail protein [Mobilome: prophages, transposons]; |
353-780 |
9.83e-06 |
|
Phage-related minor tail protein [Mobilome: prophages, transposons];
Pssm-ID: 444092 [Multi-domain] Cd Length: 603 Bit Score: 50.38 E-value: 9.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 353 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 432
Cdd:COG5281 3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 433 LEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 512
Cdd:COG5281 83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 513 EAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 592
Cdd:COG5281 160 AAAAAAAAAAAAAAAAAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 593 EITE--REMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRMLDTEKQS 670
Cdd:COG5281 240 ASAAaqALAALAAAAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAAAAQLAAA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 671 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLE 750
Cdd:COG5281 317 AAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAGAKAALAE 391
|
410 420 430
....*....|....*....|....*....|
gi 767972910 751 EQAKLQQQMDLQKNHIFRLTQGLQEALDRA 780
Cdd:COG5281 392 YADSATNVAAQVAQAATSAFSGLTDALAGA 421
|
|
| CCDC73 |
pfam15818 |
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ... |
4-326 |
1.07e-05 |
|
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.
Pssm-ID: 464893 [Multi-domain] Cd Length: 1048 Bit Score: 50.33 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 4 KLLIKSKELQDSQDKCHKMEQEMTRLHRrvsEVEAVLsQKEVELKASETQRSLLEQDLATYITE--CSSLKRSLEQarME 81
Cdd:pfam15818 32 KIIVETQELKWQKETLQNQKETLAKQHK---EAMAVF-KKQLQMKMCALEEEKGKYQLATEIKEkeIEGLKETLKA--LQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMR----LMMNQ----------LEEDLVSA----RRRSDLYESEL 143
Cdd:pfam15818 106 VSK---YSLQKKVSEMEQKLQLHLLAKEDHHKQLNEIEkyyaTITGQfglvkenhgkLEQNVQEAiqlnKRLSALNKKQE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 144 RESRLAAEEFKRKATEcqhkLLKAKDQGKPEVGEyaklEKIN-AEQQLKIQELQEKL----EKAVKASTEAT-------- 210
Cdd:pfam15818 183 SEICSLKKELKKVTSD----LIKSKVTCQYKMGE----ENINlTIKEQKFQELQERLnmelELNKKINEEIThiqeekqd 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 211 ---------ELLQNIRQAKERAEREL----EKLQNREDSSEGIRKKLVEAEERRHSLENKvkrletMERRENRLKDDIQT 277
Cdd:pfam15818 255 iiisfqhmqQLLQQQTQANTEMEAELkalkENNQTLERDNELQREKVKENEEKFLNLQNE------HEKALGTWKKHVEE 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 767972910 278 KSQQIQQMADKILELEEKHREAQvsaqhlEVHLKQKEQHYEEKIKVLDN 326
Cdd:pfam15818 329 LNGEINEIKNELSSLKETHIKLQ------EHYNKLCNQKKFEEDKKFQN 371
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
359-562 |
1.47e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 49.38 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 359 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 438
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 439 QDHSDKNRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 511
Cdd:COG4942 98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 512 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 562
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
502-771 |
1.92e-05 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 48.65 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 502 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND--- 578
Cdd:pfam15905 66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllk 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 579 -----------------EIVQLRSEVDHLRREITER----EMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDElleker 637
Cdd:pfam15905 143 akfsedgtqkkmsslsmELMKLRNKLEAKMKEVMAKqegmEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE------ 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 638 qweawrsvlgdEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKL 717
Cdd:pfam15905 217 -----------EKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQI 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 767972910 718 NDLEKKHAMLEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 771
Cdd:pfam15905 278 KDLNEKCKLLE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
|
|
| C1_SpBZZ1-like |
cd20824 |
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ... |
958-1008 |
2.00e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410374 Cd Length: 53 Bit Score: 43.46 E-value: 2.00e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 958 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1008
Cdd:cd20824 1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
262-502 |
2.01e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 49.24 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 262 ETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 341
Cdd:COG3206 164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 342 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyLETQA 419
Cdd:COG3206 242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ---LQQEA 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 420 GKLEAQnrkLEEQLEKISHQDHSDKNRLLELETRLREVSleheeqklELKRQLTELQLSLQERESQLTALQAARAALESQ 499
Cdd:COG3206 312 QRILAS---LEAELEALQAREASLQAQLAQLEARLAELP--------ELEAELRRLEREVEVARELYESLLQRLEEARLA 380
|
...
gi 767972910 500 LRQ 502
Cdd:COG3206 381 EAL 383
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
91-303 |
2.19e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.61 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 91 QLLHDIREQSRKLQEIKEQEYQAQVEemrlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQ 170
Cdd:COG4942 31 QLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 171 GKPEVGEYAKLEKI----------NAEQQLKIQELQEKLEKAVKASTEA-TELLQNIRQAKERAERELEKLQNREDSSEG 239
Cdd:COG4942 106 LAELLRALYRLGRQpplalllspeDFLDAVRRLQYLKYLAPARREQAEElRADLAELAALRAELEAERAELEALLAELEE 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 240 IRKKLVEAEERRHSLENKV-KRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSA 303
Cdd:COG4942 186 ERAALEALKAERQKLLARLeKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
221-661 |
2.72e-05 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 49.18 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 221 ERAERELEKLQNREDSSEGIRKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS------QQIQQMADKI----- 289
Cdd:COG3096 278 NERRELSERALELRRELFGARRQLAEEQYR---LVEMARELEELSARESDLEQDYQAASdhlnlvQTALRQQEKIeryqe 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 290 --LELEEKHREAQ-VSAQHLEVHLKQKEQ--HYEEKIKVLDNQikkdLADKETLENMMQRheeeahekgKILSEQKAmin 364
Cdd:COG3096 355 dlEELTERLEEQEeVVEEAAEQLAEAEARleAAEEEVDSLKSQ----LADYQQALDVQQT---------RAIQYQQA--- 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 365 amdskIRSLEqRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkleaqnrkleeqlekishqdhsdk 444
Cdd:COG3096 419 -----VQALE-KARALCGLPDLTPENAEDYLAAFRAKEQQATE------------------------------------- 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 445 nRLLELETRLReVSLEHEEQkLELKRQLTELQLSLQEREsqlTALQAARAALEsQLRQAKTELEETtaeaeeeiQALTAH 524
Cdd:COG3096 456 -EVLELEQKLS-VADAARRQ-FEKAYELVCKIAGEVERS---QAWQTARELLR-RYRSQQALAQRL--------QQLRAQ 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 525 RDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 604
Cdd:COG3096 521 LAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAAR 600
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972910 605 K----QTMEALKTTCTMLEEQVMDLEALND---ELLEKERQWEAWRSVLGDEKSQFECRVRELQ 661
Cdd:COG3096 601 ApawlAAQDALERLREQSGEALADSQEVTAamqQLLEREREATVERDELAARKQALESQIERLS 664
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
571-760 |
3.70e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.90 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 571 DEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvmdLEALNDELLEKERQWEAWRSVLGDek 650
Cdd:COG3883 16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE---IDKLQAEIAEAEAEIEERREELGE-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 651 sqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKLNDLE 721
Cdd:COG3883 91 -----RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKLAELE 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 767972910 722 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 760
Cdd:COG3883 161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
299-523 |
4.64e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.52 E-value: 4.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 299 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 378
Cdd:COG3883 3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 379 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKNRLLELETR 453
Cdd:COG3883 83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 454 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 523
Cdd:COG3883 152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
177-354 |
5.50e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 47.45 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 177 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERR----- 251
Cdd:COG4942 35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 252 --------------HSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 317
Cdd:COG4942 115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 767972910 318 EEKIKVLD----------NQIKKDLADKETLENMMQRHEEEAHEKGK 354
Cdd:COG4942 195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
254-435 |
5.52e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 47.52 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 254 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 329
Cdd:COG3883 18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 330 -----------------KDLADKETLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 392
Cdd:COG3883 98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 767972910 393 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 435
Cdd:COG3883 172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
|
|
| Filament |
pfam00038 |
Intermediate filament protein; |
369-665 |
5.98e-05 |
|
Intermediate filament protein;
Pssm-ID: 459643 [Multi-domain] Cd Length: 313 Bit Score: 46.84 E-value: 5.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 369 KIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKNRL 447
Cdd:pfam00038 19 KVRFLEQQNKLLeTKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDF-------RQKY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 448 lELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE-------SQLRQAKTELEETTAEAEEEIQA 520
Cdd:pfam00038 92 -EDELNLRT---SAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKknheeevRELQAQVSDTQVNVEMDAARKLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 521 LTAHRDEIQRKFDALRNSCTviTDLEEQLNQLTEdnaELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQ 600
Cdd:pfam00038 168 LTSALAEIRAQYEEIAAKNR--EEAEEWYQSKLE---ELQ----------QAAARNGDALRSAKEEITELRRTIQSLEIE 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 601 LTSQKQTMEALKTTCTMLEEQ-VMDLEALNDELLEKERQweawrsvLGDEKSQFECRVRELQRMLD 665
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERyELQLADYQELISELEAE-------LQETRQEMARQLREYQELLN 291
|
|
| C1_CeDKF1-like_rpt2 |
cd20798 |
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ... |
958-1009 |
6.68e-05 |
|
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410348 Cd Length: 54 Bit Score: 42.10 E-value: 6.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767972910 958 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 1009
Cdd:cd20798 1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
71-304 |
6.74e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.70 E-value: 6.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 71 LKRSLEQARMEVSQEDDKalqlLHDIREQSrKLQEIKEQE--YQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 148
Cdd:COG3206 180 LEEQLPELRKELEEAEAA----LEEFRQKN-GLVDLSEEAklLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPD 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 149 AAEEFKRKATecqhkLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKA-STEATELLQNIRQAKERAEREL 227
Cdd:COG3206 255 ALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQlQQEAQRILASLEAELEALQARE 329
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 228 EKLQNREDssegirkklveaeerrhSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQ 304
Cdd:COG3206 330 ASLQAQLA-----------------QLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVR 389
|
|
| PH_ROCK |
cd01242 |
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ... |
1041-1086 |
6.74e-05 |
|
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269948 Cd Length: 110 Bit Score: 43.88 E-value: 6.74e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 767972910 1041 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1086
Cdd:cd01242 2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
|
|
| PH_MRCK |
cd01243 |
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ... |
1043-1158 |
8.11e-05 |
|
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269949 Cd Length: 135 Bit Score: 44.21 E-value: 8.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1043 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1119
Cdd:cd01243 15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 767972910 1120 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1158
Cdd:cd01243 91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
|
|
| C1_Munc13-1 |
cd20858 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ... |
957-1007 |
8.38e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410408 Cd Length: 60 Bit Score: 42.00 E-value: 8.38e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 957 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20858 6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
274-587 |
8.60e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 47.64 E-value: 8.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 274 DIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHyEEKIKVLDNqikkdladketlENMMQRHEEeAHEKG 353
Cdd:PRK04863 838 ELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRL-LPRLNLLAD------------ETLADRVEE-IREQL 903
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 354 KILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL 433
Cdd:PRK04863 904 DEAEEAKRFVQQHGNALAQLEPIVSVL------------------QSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVV 965
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 434 EKISHQDHSDKNRLL----ELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 509
Cdd:PRK04863 966 QRRAHFSYEDAAEMLaknsDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQD 1045
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 510 T-TAEAEEEIQALTAHRDEIQrkfDALRNSCTVITDLEEQLnQLTEdnAELNNQNfylsKQLDEasgANDEIVQLRSEV 587
Cdd:PRK04863 1046 LgVPADSGAEERARARRDELH---ARLSANRSRRNQLEKQL-TFCE--AEMDNLT----KKLRK---LERDYHEMREQV 1111
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
463-754 |
8.92e-05 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 46.44 E-value: 8.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 463 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 542
Cdd:COG1340 1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 543 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV 622
Cdd:COG1340 74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELEKAK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 623 MDLEaLNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvelavKEHKAEILALQQA 702
Cdd:COG1340 154 KALE-KNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA-------DELHKEIVEAQEK 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 703 LKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 754
Cdd:COG1340 225 ADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
401-741 |
9.49e-05 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 47.04 E-value: 9.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 401 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELEtRLREVSLEHEEQKLELKRQLTELQlsLQ 480
Cdd:pfam17380 280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIR--QE 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 481 ERESQLTALQAARAALE-SQLRQAKTELEETTAEAEEEIQALTAHR------DEIQRKfdalrnsctvitdLEEQLNQLT 553
Cdd:pfam17380 357 ERKRELERIRQEEIAMEiSRMRELERLQMERQQKNERVRQELEAARkvkileEERQRK-------------IQQQKVEME 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 554 EDNAELNNQNFYLSKQLDEasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMD---LEALND 630
Cdd:pfam17380 424 QIRAEQEEARQREVRRLEE---------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDrkrAEEQRR 494
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 631 ELLEKErqWEAWRSVLGDEKSQfecrvrelQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEilaLQQALKEQKLKA 710
Cdd:pfam17380 495 KILEKE--LEERKQAMIEEERK--------RKLLEKEMEERQKAIYEEERRREAEEERRKQQEME---ERRRIQEQMRKA 561
|
330 340 350
....*....|....*....|....*....|.
gi 767972910 711 ESLSDKLNDLEKKHAMLEMNARSLQQKLETE 741
Cdd:pfam17380 562 TEERSRLEAMEREREMMRQIVESEKARAEYE 592
|
|
| C1_aPKC |
cd20794 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
960-1008 |
9.91e-05 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410344 Cd Length: 55 Bit Score: 41.48 E-value: 9.91e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767972910 960 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1008
Cdd:cd20794 9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
186-490 |
1.00e-04 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 46.34 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 186 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETM 264
Cdd:pfam15905 52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 265 ERRENRLKDDIQTK-SQQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKETLENMMQ 343
Cdd:pfam15905 131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 344 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 423
Cdd:pfam15905 196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 424 AQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 490
Cdd:pfam15905 261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
365-534 |
1.02e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 45.69 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 365 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 444
Cdd:COG1579 14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 445 NRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 512
Cdd:COG1579 73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152
|
170 180
....*....|....*....|..
gi 767972910 513 EAEEEIQALTAHRDEIQRKFDA 534
Cdd:COG1579 153 ELEAELEELEAEREELAAKIPP 174
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
96-343 |
1.13e-04 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 46.93 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 96 IREQSrklQEIKEQEYQAQVEEMRLMM---NQLEEDLVSARRRSDL---YESELREsrlaAEEFKRKATECQHKLLK-AK 168
Cdd:PHA02562 176 IRELN---QQIQTLDMKIDHIQQQIKTynkNIEEQRKKNGENIARKqnkYDELVEE----AKTIKAEIEELTDELLNlVM 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 169 DQGKPEvgeyAKLEKINAEQ---QLKIQELQeKLEKAVKASTEATELLQNIRQAKERAERELEKLQNredssegIRKKLV 245
Cdd:PHA02562 249 DIEDPS----AALNKLNTAAakiKSKIEQFQ-KVIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKE-------LQHSLE 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 246 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 325
Cdd:PHA02562 317 KLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKS 396
|
250
....*....|....*...
gi 767972910 326 NqIKKDLADKETLENMMQ 343
Cdd:PHA02562 397 E-LVKEKYHRGIVTDLLK 413
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
657-911 |
1.18e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 47.22 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 657 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 728
Cdd:COG4913 213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 729 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 807
Cdd:COG4913 290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 808 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 887
Cdd:COG4913 358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426
|
250 260
....*....|....*....|....
gi 767972910 888 EAAHRKATDHPHPSTPATARQQIA 911
Cdd:COG4913 427 EIASLERRKSNIPARLLALRDALA 450
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
475-794 |
1.19e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 46.81 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 475 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdALRNSCTVITDLEEQLNQLTE 554
Cdd:pfam07888 32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE---ELRQSREKHEELEEKYKELSA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 555 DNAELNNQNFYLSKQLDEASGandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLE 634
Cdd:pfam07888 109 SSEELSEEKDALLAQRAAHEA---RIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 635 KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEILALQQALKEQKLKAESLS 714
Cdd:pfam07888 186 ELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELRSLQERLNASERKVEGLG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 715 DKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 783
Cdd:pfam07888 258 EELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337
|
330
....*....|.
gi 767972910 784 KTERSDLEYQL 794
Cdd:pfam07888 338 RMEREKLEVEL 348
|
|
| C1_nPKC_theta-like_rpt2 |
cd20837 |
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ... |
959-1007 |
1.20e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410387 Cd Length: 50 Bit Score: 41.27 E-value: 1.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 959 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20837 1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
194-692 |
1.31e-04 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 47.13 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 194 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLQNREDSSEGIRKK--LVEAEERRHSLE---------NKV---- 258
Cdd:PTZ00440 2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 259 -KRLETMERRENRLKDDIQTKSQQIQQmADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 331
Cdd:PTZ00440 2250 kKKLLDNKNKINNIKDKINDKEKELIN-VDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 332 LADKETLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 411
Cdd:PTZ00440 2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 412 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdknrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 491
Cdd:PTZ00440 2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 492 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 566
Cdd:PTZ00440 2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 567 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSqkqtmealkttctMLEEQVMDLEALNDELLEKERQweawrsvl 646
Cdd:PTZ00440 2531 DNSTYIINELESHVSKLNELLSYIDNEIKELENEKLK-------------LLEKAKIEESRKERERIESETQ-------- 2589
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 767972910 647 GDEKSQFECRVRELQRMLDTEKQsRARADQRITESRQVVELAVKEH 692
Cdd:PTZ00440 2590 EDNTDEEQINRQQQERLQKEEEQ-KAYSQERLNREVSGTDDTNKNH 2634
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
474-833 |
1.39e-04 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 46.61 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 474 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 549
Cdd:pfam05622 11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 550 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQTMEA- 610
Cdd:pfam05622 69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKKLEDl 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 611 --LKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSRA----- 672
Cdd:pfam05622 148 gdLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLEEkleal 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 673 -RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMNAR---- 732
Cdd:pfam05622 224 qKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLGQEgsyr 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 733 ----SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKvkm 808
Cdd:pfam05622 304 erltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEAQSE--- 378
|
410 420
....*....|....*....|....*
gi 767972910 809 egtISQQTKLIDFLQAKMDQPAKKK 833
Cdd:pfam05622 379 ---LQKKKEQIEELEPKQDSNLAQK 400
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1517-1626 |
1.44e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.70 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1517 SGTEHHRGPSTSRSSPNKRGPPTynehiTKRVASSPAPPEGPSHPREPSTPH-RYREGRTELRRDKSPgrplerekspgr 1595
Cdd:PHA03307 343 PGPSPSRSPSPSRPPPPADPSSP-----RKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATG------------ 405
|
90 100 110
....*....|....*....|....*....|.
gi 767972910 1596 mlstRRERSPGRLFEDSSRGRLPAGAVRTPL 1626
Cdd:PHA03307 406 ----RFPAGRPRPSPLDAGAASGAFYARYPL 432
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
453-780 |
1.53e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.87 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 453 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 532
Cdd:PRK04863 283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 533 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEV-DHLRR--EITEREMQLTSQKQTME 609
Cdd:PRK04863 355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAA---EEEVDELKSQLaDYQQAldVQQTRAIQYQQAVQALE 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 610 ALKTTC-----------TMLEEQVMDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQ 676
Cdd:PRK04863 425 RAKQLCglpdltadnaeDWLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARE 500
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 677 RITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 754
Cdd:PRK04863 501 LLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSE 576
|
330 340
....*....|....*....|....*.
gi 767972910 755 LQQQMDLQKNHIFRLTQGLQEALDRA 780
Cdd:PRK04863 577 ARERRMALRQQLEQLQARIQRLAARA 602
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
359-791 |
1.65e-04 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 46.59 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 359 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 436
Cdd:PRK10929 43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 437 SHQdHSDKNRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAlesqLRQAKTEleetta 512
Cdd:PRK10929 115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLAQAQLT----ALQAESA------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 513 eaeeeiqALTAHRDEIqrkfdalrnsctvitdleeQLNQLTEDNAElnnqnfylskqldeasgandEIVQLRSEV----- 587
Cdd:PRK10929 184 -------ALKALVDEL-------------------ELAQLSANNRQ--------------------ELARLRSELakkrs 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 588 DHLRREITEREMQLTSQKQ--TMEALKTTcTMLEEQVMDLEALNDELLEKERQweawrsvLGDEKSQfecrvrELQRMLD 665
Cdd:PRK10929 218 QQLDAYLQALRNQLNSQRQreAERALEST-ELLAEQSGDLPKSIVAQFKINRE-------LSQALNQ------QAQRMDL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 666 TEKQSRaRADQRITESRQVveLAVKEHKAEILALQQALKEqKLKAEslSDKLNDLEKKhamlemnarslqQKLETER-EL 744
Cdd:PRK10929 284 IASQQR-QAASQTLQVRQA--LNTLREQSQWLGVSNALGE-ALRAQ--VARLPEMPKP------------QQLDTEMaQL 345
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 767972910 745 K-QRLLEEQ--AKLQQQMDLQKNHIFRLTQGLQEALDraDLLKTERSDLE 791
Cdd:PRK10929 346 RvQRLRYEDllNKQPQLRQIRQADGQPLTAEQNRILD--AQLRTQRELLN 393
|
|
| C1_aPKC_iota |
cd21094 |
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ... |
959-1010 |
1.80e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410447 Cd Length: 55 Bit Score: 40.76 E-value: 1.80e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767972910 959 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 1010
Cdd:cd21094 3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
462-676 |
1.83e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.98 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 462 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---- 537
Cdd:COG3883 15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 538 ---SCTVITDLEEQLNQltEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 614
Cdd:COG3883 95 lyrSGGSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972910 615 ctmLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 676
Cdd:COG3883 173 ---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
527-827 |
1.89e-04 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 46.10 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 527 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITERE---- 598
Cdd:COG5185 233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTksid 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 599 -----MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 671
Cdd:COG5185 307 ikkatESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 672 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 751
Cdd:COG5185 387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 752 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 827
Cdd:COG5185 458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
|
|
| COG2433 |
COG2433 |
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]; |
179-270 |
1.91e-04 |
|
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 46.00 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 179 AKLEKINAEQQLKIQELQEKLEKAvkaSTEATELLQNIRqAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV 258
Cdd:COG2433 423 ERLEAEVEELEAELEEKDERIERL---ERELSEARSEER-REIRKDREISRLDREIER---LERELEEERERIEELKRKL 495
|
90
....*....|..
gi 767972910 259 KRLETMERRENR 270
Cdd:COG2433 496 ERLKELWKLEHS 507
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
675-832 |
1.92e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 44.92 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 675 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 750
Cdd:COG1579 16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 751 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 829
Cdd:COG1579 89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
|
...
gi 767972910 830 AKK 832
Cdd:COG1579 169 AAK 171
|
|
| C1_MTMR-like |
cd20828 |
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ... |
955-1008 |
1.95e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410378 Cd Length: 57 Bit Score: 40.89 E-value: 1.95e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 955 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1008
Cdd:cd20828 2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
50-249 |
2.07e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.59 E-value: 2.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 50 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRlmmNQLEE 127
Cdd:COG3883 14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEiaEAEAEIEERR---EELGE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 128 DLVSARR--RSDLYESELRESRLAAEEFKR-----KATECQHKLLKA--KDQGKPEVGEyAKLEKINAEQQLKIQELQEK 198
Cdd:COG3883 91 RARALYRsgGSVSYLDVLLGSESFSDFLDRlsalsKIADADADLLEElkADKAELEAKK-AELEAKLAELEALKAELEAA 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 199 LEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEE 249
Cdd:COG3883 170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
196-490 |
2.18e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 45.88 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 196 QEKLEKAVKasteatellQNIRQAKERAERELEKlqnredssegiRKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 275
Cdd:pfam17380 290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 276 QTKSQQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKETLENMMQRHEEEAHEKGK 354
Cdd:pfam17380 347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 355 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 434
Cdd:pfam17380 406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 435 KISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 490
Cdd:pfam17380 464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
454-771 |
2.37e-04 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 46.06 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 454 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 530
Cdd:PRK11281 48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 531 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQKQT 607
Cdd:PRK11281 116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLKG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 608 MEALKTTCTMLEEQVMDLE-ALNDELLEKERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrARADQRITESRQVV- 685
Cdd:PRK11281 182 GKVGGKALRPSQRVLLQAEqALLNAQNDLQRKSLEGNTQLQD--------LLQKQRDYLTARI--QRLEHQLQLLQEAIn 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 686 --ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQ--QMDL 761
Cdd:PRK11281 252 skRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLLKATEKLNTltQQNL 309
|
330
....*....|.
gi 767972910 762 Q-KNHIFRLTQ 771
Cdd:PRK11281 310 RvKNWLDRLTQ 320
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
10-499 |
2.53e-04 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 45.90 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLH-RRVSEV-EAVLSQKEVELKasETQRSLLEQDLATYITECSSLKRSL-EQARMEVSQ-- 84
Cdd:pfam07111 162 EALSSLTSKAEGLEKSLNSLEtKRAGEAkQLAEAQKEAELL--RKQLSKTQEELEAQVTLVESLRKYVgEQVPPEVHSqt 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 85 ---EDDKALQLLHDIREQSRKLQEIKEQeYQAQVEEMRLMMNQLEEDLVSARRRSDLYESEL-RESRLAAEEFKRKATEC 160
Cdd:pfam07111 240 welERQELLDTMQHLQEDRADLQATVEL-LQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFpKKCRSLLNRWREKVFAL 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 161 QHKLlKAKDqgkpevgeyakLEKINAEQQLKIQ--ELQEKlekaVKASTEATELLQNIRQAKErAERELEKLqnredSSE 238
Cdd:pfam07111 319 MVQL-KAQD-----------LEHRDSVKQLRGQvaELQEQ----VTSQSQEQAILQRALQDKA-AEVEVERM-----SAK 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 239 GIRKKLVEAEERRHSLENKVKRLETMER----RENRLKDDIQTKSQQIQQMADKILELEEK--------HREAQVSAQHL 306
Cdd:pfam07111 377 GLQMELSRAQEARRRQQQQTASAEEQLKfvvnAMSSTQIWLETTMTRVEQAVARIPSLSNRlsyavrkvHTIKGLMARKV 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 307 EV-HLKQKEQHYEEKIKVLDNQIKKDLadkETLENMMQRHEEEAHEKGKILSEQKAminamdskiRSLEQRIVELSEANK 385
Cdd:pfam07111 457 ALaQLRQESCPPPPPAPPVDADLSLEL---EQLREERNRLDAELQLSAHLIQQEVG---------RAREQGEAERQQLSE 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 386 LAANsslFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQK 465
Cdd:pfam07111 525 VAQQ---LEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRL 601
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 767972910 466 LELKRQLTELQLSL----------QERESQLTALQAARAALESQ 499
Cdd:pfam07111 602 NEARREQAKAVVSLrqiqhratqeKERNQELRRLQDEARKEEGQ 645
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
240-636 |
2.70e-04 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 45.62 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 240 IRKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSQQIQQMADKILELEEKHREAqvsAQHLEVH-------L 310
Cdd:pfam06160 65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 311 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 389
Cdd:pfam06160 138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 390 sslftQRNMKAQ----EEMISELRQQKFYLETQagkleaqnrKLEEQLEKISHQDHSDKNRLLELEtrlrevsLEHEEQK 465
Cdd:pfam06160 206 -----KTELPDQleelKEGYREMEEEGYALEHL---------NVDKEIQQLEEQLEENLALLENLE-------LDEAEEA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 466 LE-LKRQLTELQLSLqEREsqltalqaaraalesqlrqakteleettaeaeeeIQAltahRDEIQRKFDALRNSctvITD 544
Cdd:pfam06160 265 LEeIEERIDQLYDLL-EKE----------------------------------VDA----KKYVEKNLPEIEDY---LEH 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 545 LEEQLNQLTEDNAELnNQNFYLS-KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 623
Cdd:pfam06160 303 AEEQNKELKEELERV-QQSYTLNeNELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQE 381
|
410
....*....|....
gi 767972910 624 DL-EALNDelLEKE 636
Cdd:pfam06160 382 EFkESLQS--LRKD 393
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
192-802 |
2.73e-04 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 45.84 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 192 IQELQEKLEKavkasteatELLQNIRQAKERAERELEKLQNREDSSEgiRKKLVEAEERRHSLENKVKRLETMERRENRL 271
Cdd:COG5022 819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEVLIQKFGRSLK--AKKRFSLLKKETIYLQSAQRVELAERQLQEL 887
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 272 KDDIQTksqqIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKETLENMMQRHEEE 348
Cdd:COG5022 888 KIDVKS----ISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 349 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 426
Cdd:COG5022 964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 427 RKLEE--QLEKISHQDHSDKNRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 504
Cdd:COG5022 1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 505 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 584
Cdd:COG5022 1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 585 SEVDHLRREITEREMQLTSQKQTME--ALKTTCTMLEEQVMDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQ 661
Cdd:COG5022 1160 FWEANLEALPSPPPFAALSEKRLYQsaLYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEY 1236
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 662 RMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSL 734
Cdd:COG5022 1237 STSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSL 1308
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 735 QQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 802
Cdd:COG5022 1309 RWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
|
|
| C1_PKD2_rpt2 |
cd20843 |
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ... |
957-1007 |
2.83e-04 |
|
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410393 Cd Length: 79 Bit Score: 41.11 E-value: 2.83e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767972910 957 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20843 10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
11-230 |
2.98e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 45.68 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL--LEQDLATYITECS---SLKRSLEQARMEVSQE 85
Cdd:COG4913 625 ELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIaeLEAELERLDASSDdlaALEEQLEELEAELEEL 704
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 86 DDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEM-------------------------RLMMNQLEEDLVSARRRSDL 138
Cdd:COG4913 705 EEELDELKGEIGRLEKELEQAEEEldELQDRLEAAedlarlelralleerfaaalgdaveRELRENLEERIDALRARLNR 784
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 139 YESELREsrlAAEEFKRKATECQHKLlkakDQGKPEVGEY-AKLEKINAEqqlKIQELQEKLEKAVKASTEA--TELLQN 215
Cdd:COG4913 785 AEEELER---AMRAFNREWPAETADL----DADLESLPEYlALLDRLEED---GLPEYEERFKELLNENSIEfvADLLSK 854
|
250
....*....|....*
gi 767972910 216 IRQAKERAERELEKL 230
Cdd:COG4913 855 LRRAIREIKERIDPL 869
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
72-247 |
3.08e-04 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 45.33 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 72 KRSLEQARMEVSQEDDKALQllHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLV----SARRRSDLYESELRESR 147
Cdd:pfam15709 345 MRRLEVERKRREQEEQRRLQ--QEQLERAEKMREELELEQQRRFEEIRLRKQRLEEERQrqeeEERKQRLQLQAAQERAR 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 148 LAAEEFKRKATECQHKllkaKDQgkpEVGEYAKLEKiNAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 227
Cdd:pfam15709 423 QQQEEFRRKLQELQRK----KQQ---EEAERAEAEK-QRQKELEMQLAEEQKRLMEMAEEERLEYQRQKQEAEEKARLEA 494
|
170 180
....*....|....*....|
gi 767972910 228 EKLQNREDssEGIRKKLVEA 247
Cdd:pfam15709 495 EERRQKEE--EAARLALEEA 512
|
|
| PRK05771 |
PRK05771 |
V-type ATP synthase subunit I; Validated |
182-382 |
3.51e-04 |
|
V-type ATP synthase subunit I; Validated
Pssm-ID: 235600 [Multi-domain] Cd Length: 646 Bit Score: 45.30 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 182 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLQNREDSS-EGIRKKLVEAEERRHSLENK 257
Cdd:PRK05771 38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 258 VKRLETMERRENRLKD-DIqtksqqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------Q 327
Cdd:PRK05771 116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvV 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 328 IKKDLADKetLENMMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 382
Cdd:PRK05771 185 VLKELSDE--VEEELKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
2-321 |
3.92e-04 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 45.01 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:TIGR04523 411 DEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKE 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 82 VSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARR---------RSDLYESELRESRLAA 150
Cdd:TIGR04523 491 LKSKEKELKKLNEEKKELEEKVKDLTKKisSLKEKIEKLESEKKEKESKISDLEDelnkddfelKKENLEKEIDEKNKEI 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 151 EEFKrkatECQHKLLKAKDQGKPEVGEYAK----LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE 226
Cdd:TIGR04523 571 EELK----QTQKSLKKKQEEKQELIDQKEKekkdLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQE 646
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 227 LEKLQNREDsseGIRKKLVEAEERRHSLENKV-KRLETMERREN----RLKDDI--QTKSQQIQQMADKILELEEKHREA 299
Cdd:TIGR04523 647 VKQIKETIK---EIRNKWPEIIKKIKESKTKIdDIIELMKDWLKelslHYKKYItrMIRIKDLPKLEEKYKEIEKELKKL 723
|
330 340
....*....|....*....|..
gi 767972910 300 QVSAQHLEVHLKQKEQHYEEKI 321
Cdd:TIGR04523 724 DEFSKELENIIKNFNKKFDDAF 745
|
|
| C1_Munc13-2-like |
cd20859 |
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ... |
953-1007 |
4.64e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410409 Cd Length: 82 Bit Score: 40.43 E-value: 4.64e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 953 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20859 14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
585-718 |
5.52e-04 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 44.19 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 585 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELlekerqwEAWRSVLGDEKSQFECRVRELQRML 664
Cdd:PRK09039 53 SALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQEL 125
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972910 665 DTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 718
Cdd:PRK09039 126 DSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
1-258 |
5.57e-04 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 44.89 E-value: 5.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKAS-------ETQRSLLEQDLATYITECSSLKR 73
Cdd:PLN02939 140 AEKNILLLNQARLQALEDLEKILTEKEALQGKINILEMRLSETDARIKLAaqekihvEILEEQLEKLRNELLIRGATEGL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 74 SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE-QEYQAQVEEMRLMMNQLEEDLVSarRRSDLYESELRESRLAAEE 152
Cdd:PLN02939 220 CVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAEtEERVFKLEKERSLLDASLRELES--KFIVAQEDVSKLSPLQYDC 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 153 FKRKATECQHKLLKAKDQgkpeVGEYAKLEKINAEQQLKIQELQEKLEKAV--KASTEATELLQN-IRQAKERAER---- 225
Cdd:PLN02939 298 WWEKVENLQDLLDRATNQ----VEKAALVLDQNQDLRDKVDKLEASLKEANvsKFSSYKVELLQQkLKLLEERLQAsdhe 373
|
250 260 270
....*....|....*....|....*....|....*.
gi 767972910 226 ---ELEKLQNREDSSEGIRKKLVEAEERRhSLENKV 258
Cdd:PLN02939 374 ihsYIQLYQESIKEFQDTLSKLKEESKKR-SLEHPA 408
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
11-226 |
5.57e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 44.67 E-value: 5.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ--------------KEVELKASETQRSLLEQDLATYITECSSLKRSLE 76
Cdd:TIGR02169 792 RIPEIQAELSKLEEEVSRIEARLREIEQKLNRltlekeylekeiqeLQEQRIDLKEQIKSIEKEIENLNGKKEELEEELE 871
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 77 QARMEVSQEDDKALQLLHDIREQSRKL--QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRE------SRL 148
Cdd:TIGR02169 872 ELEAALRDLESRLGDLKKERDELEAQLreLERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEdeeipeEEL 951
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 149 AAEEFKRKATECQHKLLKAKDQGKPEVGEYAklekinaEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE 226
Cdd:TIGR02169 952 SLEDVQAELQRVEEEIRALEPVNMLAIQEYE-------EVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREVFME 1022
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
565-800 |
5.59e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 44.62 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 565 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS--QKQTMEALKTTCTMLEEQVMDLE----ALNDELLEKER 637
Cdd:COG3206 161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELEsqlaEARAELAEAEA 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 638 QWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQKLKAe 711
Cdd:COG3206 241 RLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEAQRI- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 712 slsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTERSdle 791
Cdd:COG3206 315 -----LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAEA--- 382
|
....*....
gi 767972910 792 YQLENIQVL 800
Cdd:COG3206 383 LTVGNVRVI 391
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
3-344 |
5.96e-04 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 45.04 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 3 KKLLIKSKELQDSQDKCHK-MEQEMTRLHRRVSEVEAVLSQKEVElkaSETQRSLLEQDLATYITECSSLKRSL--EQAR 79
Cdd:TIGR01612 1361 KKIIDEVKEYTKEIEENNKnIKDELDKSEKLIKKIKDDINLEECK---SKIESTLDDKDIDECIKKIKELKNHIlsEESN 1437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 80 MEV----SQEDDKALQLL-HDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARR---RSDLYESELRESRLAAE 151
Cdd:TIGR01612 1438 IDTyfknADENNENVLLLfKNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGckdEADKNAKAIEKNKELFE 1517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 152 EFKRKATECQHKL----LKAK-DQGKP-------EVGEYAK---LEKINAEQQL-KIQELQEKLEKAVKASTEATELLQN 215
Cdd:TIGR01612 1518 QYKKDVTELLNKYsalaIKNKfAKTKKdseiiikEIKDAHKkfiLEAEKSEQKIkEIKKEKFRIEDDAAKNDKSNKAAID 1597
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 216 IRQAKERAERELEKLQNredssegIRKKLVEAEERRHSLENKVK---------RLETMERRENRLKDDIQTKSQQIQQMA 286
Cdd:TIGR01612 1598 IQLSLENFENKFLKISD-------IKKKINDCLKETESIEKKISsfsidsqdtELKENGDNLNSLQEFLESLKDQKKNIE 1670
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767972910 287 DKILELEEKHREaqvsAQHLEVHLKQKEQHYE----EKIKVLDNQIKKDL-ADKETLENMMQR 344
Cdd:TIGR01612 1671 DKKKELDELDSE----IEKIEIDVDQHKKNYEigiiEKIKEIAIANKEEIeSIKELIEPTIEN 1729
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
540-759 |
6.05e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.05 E-value: 6.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 540 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL---- 611
Cdd:COG3883 16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaral 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 612 ---KTTCTMLEeQVMDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELA 688
Cdd:COG3883 96 yrsGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAA 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 689 VKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 759
Cdd:COG3883 170 KAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
96-413 |
6.37e-04 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 96 IREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKP 173
Cdd:COG4372 33 LRKALFELDKLQEEleQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 174 EVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHS 253
Cdd:COG4372 113 LQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 254 LENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 333
Cdd:COG4372 193 NRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKD 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 334 DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 413
Cdd:COG4372 273 TEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLD 352
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
18-793 |
6.89e-04 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 44.68 E-value: 6.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 18 KCHKMEQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLATyitECSSLKRSL---EQARMEVSQEDDKALQ 91
Cdd:COG5022 794 RLFIKLQPLLSLLGSRKEYRSYLACiikLQKTIKREKKLRETEEVEFSL---KAEVLIQKFgrsLKAKKRFSLLKKETIY 870
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 92 LLHDIREQS--RKLQEIKEQEyqAQVEEMRLMMNQLEEDLVsaRRRSDLYESELRESRLAAEEFKRkaTECQHKLLKAKD 169
Cdd:COG5022 871 LQSAQRVELaeRQLQELKIDV--KSISSLKLVNLELESEII--ELKKSLSSDLIENLEFKTELIAR--LKKLLNNIDLEE 944
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 170 QGKPEVGEYAKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLQNREDSSEGIRKKLVEAEE 249
Cdd:COG5022 945 GPSIEYVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSK 1006
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 250 RRHSLENKVKRLETMERRENRLKDDIQTKSQqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIk 329
Cdd:COG5022 1007 QYGALQESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR- 1073
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 330 kdladketlenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselr 409
Cdd:COG5022 1074 ---------------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ--------- 1121
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 410 QQKFYLETQAGKLEAQNRKLEEQLEKishqdhSDKNRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTAL 489
Cdd:COG5022 1122 MIKLNLLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALY 1188
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 490 QAARAALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 569
Cdd:COG5022 1189 DEKSKLSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKF 1250
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 570 LDEASGANDEIVQLRSEVDHLRRE-ITEREMQLTSQKQTMealkttctmleeQVMDLEALNdELLEKERQWEaWRSVLGD 648
Cdd:COG5022 1251 DTPASMSNEKLLSLLNSIDNLLSSyKLEEEVLPATINSLL------------QYINVGLFN-ALRTKASSLR-WKSATEV 1316
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 649 EKSQFE----CRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLN 718
Cdd:COG5022 1317 NYNSEElddwCREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKEN 1388
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 719 DLEKKHaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 793
Cdd:COG5022 1389 NLPKEI-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
179-435 |
7.06e-04 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 43.36 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 179 AKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKV 258
Cdd:COG1340 36 EELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 259 KRLETMERRenrlkddIQTKS---QQIQQMADKILELEEKHREAQvsaqhlevhlKQKEQHyeEKIKVLDNQIKKDLADK 335
Cdd:COG1340 116 KEIERLEWR-------QQTEVlspEEEKELVEKIKELEKELEKAK----------KALEKN--EKLKELRAELKELRKEA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 336 ETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftqrnMKAQEEMISELRQQKFYL 415
Cdd:COG1340 177 EEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEK--------------ADELHEEIIELQKELREL 242
|
250 260
....*....|....*....|
gi 767972910 416 ETQAGKLEAQNRKLEEQLEK 435
Cdd:COG1340 243 RKELKKLRKKQRALKREKEK 262
|
|
| C1_dGM13116p-like |
cd20831 |
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ... |
970-1007 |
7.49e-04 |
|
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410381 Cd Length: 58 Bit Score: 39.25 E-value: 7.49e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 767972910 970 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20831 17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
471-688 |
7.71e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 7.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 471 QLTELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQRKFDALRNSctvITDLEEQLN 550
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEE-----------YNELQAELEALQAEIDKLQAE---IAEAEAEIE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 551 QLTEDNAELNNQNF---YLSKQLDEASGANDeIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEA 627
Cdd:COG3883 83 ERREELGERARALYrsgGSVSYLDVLLGSES-FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767972910 628 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 688
Cdd:COG3883 162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
1-152 |
8.33e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 8.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883 42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883 122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200
|
170
....*....|....
gi 767972910 139 YESELRESRLAAEE 152
Cdd:COG3883 201 LEAELAAAEAAAAA 214
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
665-824 |
8.53e-04 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 43.85 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 665 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 735
Cdd:PHA02562 202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 736 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 805
Cdd:PHA02562 282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356
|
170
....*....|....*....
gi 767972910 806 vkmEGTISQQTKLIDFLQA 824
Cdd:PHA02562 357 ---VDKAKKVKAAIEELQA 372
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
312-840 |
1.05e-03 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 44.06 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 312 QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEAnklaANSS 391
Cdd:pfam12128 237 MKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASR---QEERQETSAELNQLLRTLDDQWKEKRDE----LNGE 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 392 LFTQRnmkaqeEMISELRQQKFYLETQAGKLE---AQNRKLE-EQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLE 467
Cdd:pfam12128 310 LSAAD------AAVAKDRSELEALEDQHGAFLdadIETAAADqEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSK 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 468 LKRQLT--------ELQLSLQERESQLTALQAARAALESQLRQAKTeleettaeaeeeiQALTAHRDEIQRKFDALRNSC 539
Cdd:pfam12128 384 IKEQNNrdiagikdKLAKIREARDRQLAVAEDDLQALESELREQLE-------------AGKLEFNEEEYRLKSRLGELK 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 540 TVITDL---EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK---- 612
Cdd:pfam12128 451 LRLNQAtatPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELElqlf 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 613 ----TTCTMLEEQVMDLE-----ALNDELLEK-ERQWEAWRSVLGDEKSQFECRVReLQRM-----LDTEKQSRARADQr 677
Cdd:pfam12128 531 pqagTLLHFLRKEAPDWEqsigkVISPELLHRtDLDPEVWDGSVGGELNLYGVKLD-LKRIdvpewAASEEELRERLDK- 608
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 678 itesrqvvelaVKEhkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 757
Cdd:pfam12128 609 -----------AEE------ALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNK 671
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 758 QmdlqknhifrLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLF 837
Cdd:pfam12128 672 A----------LAERKDSANERLNSLEAQLKQLDKKHQ--AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIA 739
|
...
gi 767972910 838 SRR 840
Cdd:pfam12128 740 ARR 742
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
72-498 |
1.11e-03 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 43.35 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 72 KRSLEQARMEVSQEDD----KALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEdlvsarrrsdlyesELRESR 147
Cdd:pfam07888 28 RAELLQNRLEECLQERaellQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE--------------ELRQSR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 148 LAAEEFKRKATEcqhkllkAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEK-AVKASTEATELlqniRQAKERAERE 226
Cdd:pfam07888 94 EKHEELEEKYKE-------LSASSEELSEEKDALLAQRAAHEARIRELEEDIKTlTQRVLERETEL----ERMKERAKKA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 227 LEKLQNREDSSEGIRKKLVEAEERRHSLENKVKrletmerrenRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhl 306
Cdd:pfam07888 163 GAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQ----------ELRNSLAQRDTQVLQLQDTITTLTQKLTTAH------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 307 evhlkQKEQHYEekikvldnQIKKDLADKETLENMMQRHEEeahekgKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 386
Cdd:pfam07888 227 -----RKEAENE--------ALLEELRSLQERLNASERKVE------GLGEELSSMAAQRDRTQAELHQARLQAAQLTLQ 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 387 AANSSLF--------------TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL--EKISH--QDHSDKNRLL 448
Cdd:pfam07888 288 LADASLAlregrarwaqeretLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVELgrEKDCNrvQLSESRRELQ 367
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 767972910 449 ELETRLReVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 498
Cdd:pfam07888 368 ELKASLR-VAQKEKEQLQAEKQELLEYIRQLEQRLETVADAKWSEAALTS 416
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
211-650 |
1.12e-03 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 43.35 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 211 ELLQNIRQAKERAERELekLQNREDSSEGIRKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSQQIQQMADKIL 290
Cdd:pfam07888 30 ELLQNRLEECLQERAEL--LQAQEAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 291 ELEEKHREAQVS----AQHLEVHLKQKEQHyEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM 366
Cdd:pfam07888 98 ELEEKYKELSASseelSEEKDALLAQRAAH-EARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 367 DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfyleTQAGKLEAQNRKLEEQLEKISHQDHSDKNR 446
Cdd:pfam07888 177 QAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKL----TTAHRKEAENEALLEELRSLQERLNASERK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 447 LLELETRLREVSLEHEEQKLELKR-QLTELQLSLQERESQLtALQAARAalesQLRQAKTELEETTAEAEEEIQALTAhr 525
Cdd:pfam07888 253 VEGLGEELSSMAAQRDRTQAELHQaRLQAAQLTLQLADASL-ALREGRA----RWAQERETLQQSAEADKDRIEKLSA-- 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 526 dEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqldeasgandeiVQLRSEVDHLRREITEREMQLTSQK 605
Cdd:pfam07888 326 -ELQRL--------------EERLQEERMEREKLE--------------------VELGREKDCNRVQLSESRRELQELK 370
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 767972910 606 QTMEALKTTctmlEEQvmdLEALNDELLEKERQWEAWRSVLGDEK 650
Cdd:pfam07888 371 ASLRVAQKE----KEQ---LQAEKQELLEYIRQLEQRLETVADAK 408
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
186-411 |
1.17e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.28 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 186 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSsegIRKKLVEAEERRHSLENKV-KRLETM 264
Cdd:COG3883 19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK---LQAEIAEAEAEIEERREELgERARAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 265 ERRENRLKD-DIQTKSQQIQQMADKILELEekhreaQVSAQHLEVHLKQKEQhyEEKIKVLDNQIKKDLADKETLENMMQ 343
Cdd:COG3883 96 YRSGGSVSYlDVLLGSESFSDFLDRLSALS------KIADADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELE 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 344 RHEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 411
Cdd:COG3883 168 AAKAELEAQ---QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAA 232
|
|
| Stathmin |
pfam00836 |
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ... |
231-319 |
1.18e-03 |
|
Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.
Pssm-ID: 459956 [Multi-domain] Cd Length: 136 Bit Score: 40.79 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 231 QNREDSSEGIRKKLVEAEERRHSLE-NKVKRL-ETMER-RENRLKDDIQTK--SQQIQQMADKILELEEKHREAQVSAqh 305
Cdd:pfam00836 38 KKKDSSLEEIQKKLEAAEERRKSLEaQKLKQLaEKREKeEEALQKADEENNnfSKMAEEKLKQKMEAYKENREAQIAA-- 115
|
90
....*....|....
gi 767972910 306 LEVHLKQKEQHYEE 319
Cdd:pfam00836 116 LKEKLKEKEKHVEE 129
|
|
| HMMR_N |
pfam15905 |
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ... |
3-257 |
1.32e-03 |
|
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Pssm-ID: 464932 [Multi-domain] Cd Length: 329 Bit Score: 42.88 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 3 KKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEV 82
Cdd:pfam15905 66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNELLKAKF 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 83 SQE-DDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK---RKAT 158
Cdd:pfam15905 146 SEDgTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKsetEKLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 159 ECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKL-EKAVKAST---EATELLQNIRQAKERAEREL-EKLQNR 233
Cdd:pfam15905 226 EYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLeEKEQELSKqikDLNEKCKLLESEKEELLREYeEKEQTL 305
|
250 260
....*....|....*....|....
gi 767972910 234 EDSSEGIRKKLVEAEERRHSLENK 257
Cdd:pfam15905 306 NAELEELKEKLTLEEQEHQKLQQK 329
|
|
| C1_MRCKalpha |
cd20864 |
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ... |
959-1012 |
1.39e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410414 Cd Length: 60 Bit Score: 38.46 E-value: 1.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 959 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 1012
Cdd:cd20864 3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
104-501 |
1.51e-03 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 43.50 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 104 QEIKEQE-----YQAQ-VEEMRLMMNQLEEDLVSARRrsdlyeseLRESRLAAEEFKRKATECQHKLLKAKDQGKPevge 177
Cdd:PRK10929 30 QELEQAKaaktpAQAEiVEALQSALNWLEERKGSLER--------AKQYQQVIDNFPKLSAELRQQLNNERDEPRS---- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 178 yaklekinAEQQLKIQELQEKLekaVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENK 257
Cdd:PRK10929 98 --------VPPNMSTDALEQEI---LQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGTP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 258 VKRLEtmerrenrlkdDIQTKSQQIQQMADKIL--ELEEkhreAQVSA---QHL-----EVHLKQKEQhyeekikvLDNQ 327
Cdd:PRK10929 167 NTPLA-----------QAQLTALQAESAALKALvdELEL----AQLSAnnrQELarlrsELAKKRSQQ--------LDAY 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 328 IKkdlADKETLENMMQRHEEEAHEKGKILSEQKAminAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMIs 406
Cdd:PRK10929 224 LQ---ALRNQLNSQRQREAERALESTELLAEQSG---DLPKSIVAQFKINRELSQAlNQQAQRMDLIASQQRQAASQTL- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 407 ELRQQKFYLETQAGKLEAQN---RKLEEQLEKIshqdhSDKNRLLELET---RLREVSLEHEEQkLELKRQLTELQlslQ 480
Cdd:PRK10929 297 QVRQALNTLREQSQWLGVSNalgEALRAQVARL-----PEMPKPQQLDTemaQLRVQRLRYEDL-LNKQPQLRQIR---Q 367
|
410 420
....*....|....*....|.
gi 767972910 481 ERESQLTALQaaRAALESQLR 501
Cdd:PRK10929 368 ADGQPLTAEQ--NRILDAQLR 386
|
|
| C1_MRCK |
cd20809 |
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ... |
959-1010 |
1.52e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410359 Cd Length: 53 Bit Score: 38.02 E-value: 1.52e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 767972910 959 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 1010
Cdd:cd20809 1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
470-892 |
1.57e-03 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 43.50 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 470 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 544
Cdd:PRK10929 2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 545 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTsQKQTmEALKt 613
Cdd:PRK10929 82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLP-QQQT-EARR- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 614 tctMLEEQVMDLEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQrmldtekQSRARADQRITESRQVVELAVKEHk 693
Cdd:PRK10929 152 ---QLNEIERRLQTLGTPNTPLA---QAQLTALQAESAALKALVDELE-------LAQLSANNRQELARLRSELAKKRS- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 694 AEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrLLEEQAklqQQMDL 761
Cdd:PRK10929 218 QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-ALNQQA---QRMDL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 762 ----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKL 818
Cdd:PRK10929 284 iasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPQL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 819 IDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTRielrsareEAAHR 892
Cdd:PRK10929 363 RQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN--------EATHR 429
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
140-396 |
1.73e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 43.41 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 140 ESELRESRLAAEEFKRKATECQHKLLKAK---DQGKPEVGEYAKLE---KINAEQQL--KIQELQEKLEKAvkasTEATE 211
Cdd:PRK04863 836 EAELRQLNRRRVELERALADHESQEQQQRsqlEQAKEGLSALNRLLprlNLLADETLadRVEEIREQLDEA----EEAKR 911
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 212 LLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRL-ETMERRENRLKDDIQTKSQQIQQMADKil 290
Cdd:PRK04863 912 FVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALtEVVQRRAHFSYEDAAEMLAKNSDLNEK-- 989
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 291 eLEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDN-----QIKKDLAD--KETLENMMQRHEEEAHEKGKILSEQ-KAM 362
Cdd:PRK04863 990 -LRQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASlkssyDAKRQMLQelKQELQDLGVPADSGAEERARARRDElHAR 1068
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 767972910 363 INAMDSKIRSLEQRIV----ELSEANKL--AANSSLFTQR 396
Cdd:PRK04863 1069 LSANRSRRNQLEKQLTfceaEMDNLTKKlrKLERDYHEMR 1108
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
144-488 |
1.75e-03 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 43.28 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 144 RESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERA 223
Cdd:PTZ00440 435 LYSNLEIIEIKKKYDEKINELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEKVDELLQIINSIKEKN 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 224 ERELEKLQNREDSS---EGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ 300
Cdd:PTZ00440 515 NIVNNNFKNIEDYYitiEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEENVDHIKDIISLNDEID 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 301 VSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLadKETLENMMQRH-EEEAHEKGKILSEQKAMINAMDSKirsleQRIVE 379
Cdd:PTZ00440 595 NIIQQIE-ELINEALFNKEKFINEKNDLQEKV--KYILNKFYKGDlQELLDELSHFLDDHKYLYHEAKSK-----EDLQT 666
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 380 L-----SEANKLA-ANSSLFTQ--RNMKAQEEMISELRQQkfyletqagkleaqnrKLEEQLEKIsHQDHSDK-NRLLEL 450
Cdd:PTZ00440 667 LlntskNEYEKLEfMKSDNIDNiiKNLKKELQNLLSLKEN----------------IIKKQLNNI-EQDISNSlNQYTIK 729
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 767972910 451 ETRLREV--SLEHEEQKLELKRQ-----LTELQLSLQERESQLTA 488
Cdd:PTZ00440 730 YNDLKSSieEYKEEEEKLEVYKHqiinrKNEFILHLYENDKDLPD 774
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
523-723 |
1.94e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 42.69 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 523 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----NDEIVQLRSEVDHLRREITERE 598
Cdd:PHA02562 213 ENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNTAAAKIKSKIEQFQKVIKMYE 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 599 ---------MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQRMLDTEKQ 669
Cdd:PHA02562 283 kggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK-----------KLLELKNKISTNKQ 351
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 670 SRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKLNDLEKK 723
Cdd:PHA02562 352 SLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTKSELVKE 401
|
|
| C1_TNS1_v |
cd20888 |
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ... |
959-1006 |
2.00e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410438 Cd Length: 57 Bit Score: 37.93 E-value: 2.00e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767972910 959 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 1006
Cdd:cd20888 6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
271-470 |
2.06e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.84 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 271 LKDDIQTKSQQIQQMADKILEleEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKET----LENMMQRHE 346
Cdd:PRK12704 25 RKKIAEAKIKEAEEEAKRILE--EAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRERRNelqkLEKRLLQKE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 347 EeahekgkilseqkaminAMDSKIRSLEQRIVELseanklaansslftqrnmkaqEEMISELRQQKFYLETQAGKLEAQN 426
Cdd:PRK12704 96 E-----------------NLDRKLELLEKREEEL---------------------EKKEKELEQKQQELEKKEEELEELI 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 427 RKLEEQLEKISHQDHSD-KNRLLE-LETRLRE-----VSLEHEEQKLELKR 470
Cdd:PRK12704 138 EEQLQELERISGLTAEEaKEILLEkVEEEARHeaavlIKEIEEEAKEEADK 188
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
40-204 |
2.10e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 41.45 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 40 LSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQeyQAQVEEMR 119
Cdd:COG1579 12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRNNK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 120 lMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEyakLEKINAEQQLKIQELQEKL 199
Cdd:COG1579 90 -EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAER 165
|
....*
gi 767972910 200 EKAVK 204
Cdd:COG1579 166 EELAA 170
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
1-454 |
2.20e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 42.85 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARM 80
Cdd:pfam01576 550 LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEA 629
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 81 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ------------------------------AQVEEMRLMMNQLEEDLV 130
Cdd:pfam01576 630 EAREKETRALSLARALEEALEAKEELERTNKQlraemedlvsskddvgknvhelerskraleQQVEEMKTQLEELEDELQ 709
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 131 S---ARRRSDL--------YESELRESRLAAEEFKR----KATECQHKLLKAKDQGKPEVGEYAKLEkinaeqqLKIQEL 195
Cdd:pfam01576 710 AtedAKLRLEVnmqalkaqFERDLQARDEQGEEKRRqlvkQVRELEAELEDERKQRAQAVAAKKKLE-------LDLKEL 782
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 196 QEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKklvEAEERRHSLENKVKRLETMERRENRLKDDI 275
Cdd:pfam01576 783 EAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSK---ESEKKLKNLEAELLQLQEDLAASERARRQA 859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 276 QTKSQQIQ------------------QMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKET 337
Cdd:pfam01576 860 QQERDELAdeiasgasgksalqdekrRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQ----LTTELAAERSTSQK 935
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 338 LENMMQRHEEEAHE--------KGKILSEQKAMINAMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMI---- 405
Cdd:pfam01576 936 SESARQQLERQNKElkaklqemEGTVKSKFKSSIAALEAKIAQLEEQLEQ--ESRERQAANKLVRRTEKKLKEVLLqved 1013
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 406 ----------------SELRQQKFYL---ETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRL 454
Cdd:pfam01576 1014 errhadqykdqaekgnSRMKQLKRQLeeaEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
260-559 |
2.22e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 42.69 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 260 RLETMERREnRLKD--DIQTKSQqiqqMaDKILEleEKHREAQVSAQHLEV---HLKQKEQHYEEKIKVLDNQIKKDLAD 334
Cdd:PHA02562 146 QLSAPARRK-LVEDllDISVLSE----M-DKLNK--DKIRELNQQIQTLDMkidHIQQQIKTYNKNIEEQRKKNGENIAR 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 335 KEtleNMMQRHEEEAhekgkilseqkamiNAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEEMISELRQQKF 413
Cdd:PHA02562 218 KQ---NKYDELVEEA--------------KTIKAEIEELTDELLNLVmDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKM 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 414 YLETQAGKLEAQNrkLEEQLEKIShqdhSDKNRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 493
Cdd:PHA02562 281 YEKGGVCPTCTQQ--ISEGPDRIT----KIKDKLKELQHSLEKLD-TAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 494 AALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 559
Cdd:PHA02562 354 ITLVDKAKKVK---------------------AAIEELQAEFVDNAEELAKLQDELDKIVKTKSEL 398
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2-284 |
2.34e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 43.02 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKME---QEMTRLHRRVSEVEAV------LSQKEVELKASETQRSLLEQDLATYITECSSLK 72
Cdd:PRK04863 785 EKRIEQLRAEREELAERYATLSfdvQKLQRLHQAFSRFIGShlavafEADPEAELRQLNRRRVELERALADHESQEQQQR 864
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 73 RSLEQARMEVSQ-----------EDDKALQLLHDIREQSRKLQEIKE--QEYQAQVEEMRLMMNQLEEDLVS-ARRRSDL 138
Cdd:PRK04863 865 SQLEQAKEGLSAlnrllprlnllADETLADRVEEIREQLDEAEEAKRfvQQHGNALAQLEPIVSVLQSDPEQfEQLKQDY 944
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 139 YESELRESRLAAEEFkrkatecqhkLLKAKDQGKPEVGeYAKLEKI-NAEQQLKIQeLQEKLEKAVKASTEATELLqniR 217
Cdd:PRK04863 945 QQAQQTQRDAKQQAF----------ALTEVVQRRAHFS-YEDAAEMlAKNSDLNEK-LRQRLEQAEQERTRAREQL---R 1009
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 218 QAKER------------------------AERELEKLQNREDSSEGIR---------KKLVEAEERRHSLENKVKRLE-- 262
Cdd:PRK04863 1010 QAQAQlaqynqvlaslkssydakrqmlqeLKQELQDLGVPADSGAEERararrdelhARLSANRSRRNQLEKQLTFCEae 1089
|
330 340
....*....|....*....|....
gi 767972910 263 --TMERRENRLKDDIQTKSQQIQQ 284
Cdd:PRK04863 1090 mdNLTKKLRKLERDYHEMREQVVN 1113
|
|
| C1_ScPKC1-like_rpt1 |
cd20822 |
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ... |
954-1007 |
2.37e-03 |
|
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410372 Cd Length: 52 Bit Score: 37.65 E-value: 2.37e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 954 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20822 3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
24-303 |
2.49e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 42.63 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 24 QEMTRLHRRVSE------VEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQ-----------ED 86
Cdd:COG3096 809 QKLQRLHQAFSQfvgghlAVAFAPDPEAELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLlnkllpqanllAD 888
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 87 DKALQLLHDIREQSRKLQEIKE--QEYQAQVEEMrlmmnqleEDLVSARRRSDLYESELRESRLAAEEfKRKATECQHKL 164
Cdd:COG3096 889 ETLADRLEELREELDAAQEAQAfiQQHGKALAQL--------EPLVAVLQSDPEQFEQLQADYLQAKE-QQRRLKQQIFA 959
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 165 LKAKDQGKPEVGeYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNI-----------------RQAKER----A 223
Cdd:COG3096 960 LSEVVQRRPHFS-YEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAqaqysqynqvlaslkssRDAKQQtlqeL 1038
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 224 ERELEKLQNREDSSEGIRkklveAEERRHSLENKVKRLETmerRENRLKDDIQTKSQQIQQMADKILELEEKH---REAQ 300
Cdd:COG3096 1039 EQELEELGVQADAEAEER-----ARIRRDELHEELSQNRS---RRSQLEKQLTRCEAEMDSLQKRLRKAERDYkqeREQV 1110
|
...
gi 767972910 301 VSA 303
Cdd:COG3096 1111 VQA 1113
|
|
| CCDC22 |
pfam05667 |
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ... |
542-722 |
2.50e-03 |
|
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 42.32 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 542 ITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 621
Cdd:pfam05667 337 LEELQEQLEDLESSIQELE----------KEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKL 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 622 VMDLEALNDELLEKERQWEAWRSVLGDEksqfecrVRELqrmldtekqsRARADQRITESRQVVElAVKEHKAEIlalQQ 701
Cdd:pfam05667 407 QALVDASAQRLVELAGQWEKHRVPLIEE-------YRAL----------KEAKSNKEDESQRKLE-EIKELREKI---KE 465
|
170 180
....*....|....*....|.
gi 767972910 702 ALKEQKLKAESLSDKLNDLEK 722
Cdd:pfam05667 466 VAEEAKQKEELYKQLVAEYER 486
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
217-491 |
2.59e-03 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 42.58 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 217 RQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLENKVKRlETMERRENRLKDDIQTKSQQIQQmADKILELEEKH 296
Cdd:PLN02939 38 RRRGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLR-TVMELPQKSTSSDDDHNRASMQR-DEAIAAIDNEQ 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 297 RE-----AQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKEtlenmmqrheeeahekgKILSEQKAMinamDSKIR 371
Cdd:PLN02939 116 QTnskdgEQLSDFQLE-DLVGMIQNAEKNILLLNQARLQALEDLE-----------------KILTEKEAL----QGKIN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 372 SLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQkfyLETQAGKLEAqnrkLEEQLEKISHQDHSDKNRLLELE 451
Cdd:PLN02939 174 ILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIR---GATEGLCVHS----LSKELDVLKEENMLLKDDIQFLK 246
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 767972910 452 TRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQA 491
Cdd:PLN02939 247 AELIEVA-ETEERVFKLEKERSLLDASLRELESKFIVAQE 285
|
|
| ATG16 |
pfam08614 |
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ... |
479-635 |
2.87e-03 |
|
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
Pssm-ID: 462536 [Multi-domain] Cd Length: 176 Bit Score: 40.30 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 479 LQERESQLTALQAA-RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTvitDLEEQLNQLTEDNA 557
Cdd:pfam08614 12 LLDRTALLEAENAKlQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRG---ELAQRLVDLNEELQ 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 558 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEK 635
Cdd:pfam08614 89 ELEKKLREDERRLAALE---AERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENRELVER 163
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
674-810 |
3.08e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.07 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 674 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 753
Cdd:PRK12704 62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 754 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 810
Cdd:PRK12704 139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
70-276 |
3.21e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 3.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 70 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQL--------EEDLVSARRRSDLYES 141
Cdd:COG4717 320 ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagvedEEELRAALEQAEEYQE 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 142 ELRESRLAAEEFKRKATECQHKLlkakdqgkpevgEYAKLEKINAEqqlkIQELQEKLEkavkastEATELLQNIRQAKE 221
Cdd:COG4717 400 LKEELEELEEQLEELLGELEELL------------EALDEEELEEE----LEELEEELE-------ELEEELEELREELA 456
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 767972910 222 RAERELEKLQNREDSSEgIRKKLVEAEERRHSLENKVKRL----ETMERRENRLKDDIQ 276
Cdd:COG4717 457 ELEAELEQLEEDGELAE-LLQELEELKAELRELAEEWAALklalELLEEAREEYREERL 514
|
|
| COG1340 |
COG1340 |
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]; |
41-330 |
3.36e-03 |
|
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
Pssm-ID: 440951 [Multi-domain] Cd Length: 297 Bit Score: 41.43 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 41 SQKEVELKASE--TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVE 116
Cdd:COG1340 9 SLEELEEKIEElrEEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEErdELNEKLN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 117 EMRLMMNQLEEDLvsarrrsdlyeSELRESRLAAEEFKRkatecqhkllkakdqgkpevgEYAKLEK--------INAEQ 188
Cdd:COG1340 89 ELREELDELRKEL-----------AELNKAGGSIDKLRK---------------------EIERLEWrqqtevlsPEEEK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 189 QL--KIQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLenkVKRLET 263
Cdd:COG1340 137 ELveKIKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADE 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767972910 264 MERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKK 330
Cdd:COG1340 214 LHKEIVEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK 278
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
572-892 |
3.76e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 42.25 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 572 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEeqvMDLEALNDEL---LEKERQWEAWRSVLGD 648
Cdd:PRK04863 280 ERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLE---QDYQAASDHLnlvQTALRQQEKIERYQAD 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 649 eksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELA---VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 725
Cdd:PRK04863 357 --------LEELEERLEEQNEVVEEADEQQEENEARAEAAeeeVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQ 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 726 ML---EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ------------EALDRADLLKTERSDL 790
Cdd:PRK04863 429 LCglpDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQlvrkiagevsrsEAWDVARELLRRLREQ 508
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 791 EYQLENIQVLYSHEKvKMEGTISQQTKLIDFLQAkmdqpAKKKkglFSRRKEDPALPTQVPLQYNELKLALEKEKARCAE 870
Cdd:PRK04863 509 RHLAEQLQQLRMRLS-ELEQRLRQQQRAERLLAE-----FCKR---LGKNLDDEDELEQLQEELEARLESLSESVSEARE 579
|
330 340
....*....|....*....|..
gi 767972910 871 LEEALQKTRIELRSAREEAAHR 892
Cdd:PRK04863 580 RRMALRQQLEQLQARIQRLAAR 601
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
192-319 |
4.12e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 41.74 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 192 IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDssegirKKLVEAEERrhsLENKVKrlETMERRENRL 271
Cdd:PRK00409 522 IASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEED------KLLEEAEKE---AQQAIK--EAKKEADEII 590
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 767972910 272 KDDIQTKSQQIQQMADKilELEEKHREAQVSAQHLEVHLKQKEQHYEE 319
Cdd:PRK00409 591 KELRQLQKGGYASVKAH--ELIEARKRLNKANEKKEKKKKKQKEKQEE 636
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
72-230 |
4.19e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.69 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 72 KRSLEQARMEVSQEDDKAL----QLLHDIREQ-----SRKLQEIKEQEYQAQVEEMRLmmNQLEEDLVSARRRSDLYESE 142
Cdd:PRK12704 41 KRILEEAKKEAEAIKKEALleakEEIHKLRNEfekelRERRNELQKLEKRLLQKEENL--DRKLELLEKREEELEKKEKE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 143 LRESRlaaEEFKRKATECQHKLLKAKDqgkpevgeyaKLEKI---NAEQqlKIQELQEKLEKavKASTEATELLQNI-RQ 218
Cdd:PRK12704 119 LEQKQ---QELEKKEEELEELIEEQLQ----------ELERIsglTAEE--AKEILLEKVEE--EARHEAAVLIKEIeEE 181
|
170
....*....|..
gi 767972910 219 AKERAERELEKL 230
Cdd:PRK12704 182 AKEEADKKAKEI 193
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
344-757 |
4.30e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.87 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 344 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 419
Cdd:PRK04863 276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 420 GKLEAQNRKLEEQLEKISHQDhsdkNRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESq 499
Cdd:PRK04863 355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALER- 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 500 LRQAKTELEETTAEAEEEIQALTAHRDEIQrkfDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLdeasgaNDE 579
Cdd:PRK04863 426 AKQLCGLPDLTADNAEDWLEEFQAKEQEAT---EELL-------SLEQKLS-VAQAAHSQFEQAYQLVRKI------AGE 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 580 IVqlRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE---EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 656
Cdd:PRK04863 489 VS--RSEAWDVARELLRRLREQRHLAEQLQQLRMRLSELEqrlRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR 566
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 657 VRELqrmldteKQSRARADQRITESRQVVElavkEHKAEIlalqQALKEQKLKAESLSDKLNDL-EKKHAMLEMNAR--- 732
Cdd:PRK04863 567 LESL-------SESVSEARERRMALRQQLE----QLQARI----QRLAARAPAWLAAQDALARLrEQSGEEFEDSQDvte 631
|
410 420 430
....*....|....*....|....*....|....*
gi 767972910 733 SLQQKLETEREL----------KQRLLEEQAKLQQ 757
Cdd:PRK04863 632 YMQQLLERERELtverdelaarKQALDEEIERLSQ 666
|
|
| C1_PKD_rpt2 |
cd20796 |
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ... |
958-1007 |
4.93e-03 |
|
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410346 Cd Length: 54 Bit Score: 36.88 E-value: 4.93e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 958 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20796 1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
|
|
| GAS |
pfam13851 |
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ... |
183-330 |
4.99e-03 |
|
Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.
Pssm-ID: 464001 [Multi-domain] Cd Length: 200 Bit Score: 39.89 E-value: 4.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 183 KINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRedsSEGIRKKLVEAEERRHSLENKVKRLE 262
Cdd:pfam13851 19 DITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEE---VEELRKQLENYEKDKQSLKNLKARLK 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 263 TMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQvsaqhLEVHLKQKEQHY--EEKIKVLDNQIKK 330
Cdd:pfam13851 96 VLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAAI-----QDVQQKTGLKNLllEKKLQALGETLEK 160
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
582-902 |
5.00e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 41.65 E-value: 5.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 582 QLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ---VMDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVR 658
Cdd:pfam17380 300 RLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQermAMERERELERIRQEERKRELER-IRQEEIAMEISRMR 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 659 ELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMNARSLQ-QK 737
Cdd:pfam17380 379 ELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEEARQREvRR 439
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 738 LETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEKVKMEGTIS 813
Cdd:pfam17380 440 LEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELEERKQAMIE 510
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 814 QQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIELRSAREEA 889
Cdd:pfam17380 511 EERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREMMRQIVESE 585
|
330
....*....|...
gi 767972910 890 AHRKATDHPHPST 902
Cdd:pfam17380 586 KARAEYEATTPIT 598
|
|
| PRK12705 |
PRK12705 |
hypothetical protein; Provisional |
178-314 |
5.01e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 237178 [Multi-domain] Cd Length: 508 Bit Score: 41.23 E-value: 5.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 178 YAKLEKINAEQQLKIQELQEKLEKAVKASTEAT--ELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEERRHSLE 255
Cdd:PRK12705 32 AKEAERILQEAQKEAEEKLEAALLEAKELLLRErnQQRQEARREREELQREEERLVQKEEQLDARAEKLDNLENQLEERE 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767972910 256 NKVK-----RLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQ-VSAQHLEVHLKQKE 314
Cdd:PRK12705 112 KALSareleLEELEKQLDNELYRVAGLTPEQARKLLLKLLDAELEEEKAQrVKKIEEEADLEAER 176
|
|
| pepcterm_ChnLen |
TIGR03007 |
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this ... |
583-762 |
5.03e-03 |
|
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this protein family belong to the family of polysaccharide chain length determinant proteins (pfam02706). All are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria, and are found near the epsH homolog that is the putative exosortase gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 274386 [Multi-domain] Cd Length: 498 Bit Score: 41.19 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 583 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE-----EQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRV 657
Cdd:TIGR03007 202 YYSEISEAQEELEAARLELNEAIAQRDALKRQLGGEEpvllaGSSVANSELDGRIEALEKQLDALRLRYTDKHPDVI-AT 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 658 RELQRMLDTEKQSRARADQRITESR-------QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmn 730
Cdd:TIGR03007 281 KREIAQLEEQKEEEGSAKNGGPERGeianpvyQQLQIELAEAEAEIASLEARVAELTARIERLESLLRTIPEVEAELT-- 358
|
170 180 190
....*....|....*....|....*....|....
gi 767972910 731 arSLQQKLETERELKQRLLE--EQAKLQQQMDLQ 762
Cdd:TIGR03007 359 --QLNRDYEVNKSNYEQLLTrrESAEVSKQMEVQ 390
|
|
| C1_TNS2 |
cd20887 |
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ... |
958-1010 |
5.15e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410437 Cd Length: 53 Bit Score: 36.68 E-value: 5.15e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 767972910 958 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 1010
Cdd:cd20887 2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
10-271 |
5.17e-03 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 41.21 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 10 KELQDSQDKCHKMEQEMTRLHRRVS----EVEAVLSQKEV------ELKASETQRSLLEQdlATYITECSSLKRSLEQAR 79
Cdd:pfam05622 197 GKLSEESKKADKLEFEYKKLEEKLEalqkEKERLIIERDTlretneELRCAQLQQAELSQ--ADALLSPSSDPGDNLAAE 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 80 MEVSQEDDKALQLLHD---IREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE---- 152
Cdd:pfam05622 275 IMPAEIREKLIRLQHEnkmLRLGQEGSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEqgsk 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 153 ------FKRKATECQHKLLKAKDQGKPEVGEYAKLE-KINAEQQLKIQELQEKLEKAVkasteatellQNIRQAKERAER 225
Cdd:pfam05622 355 aedsslLKQKLEEHLEKLHEAQSELQKKKEQIEELEpKQDSNLAQKIDELQEALRKKD----------EDMKAMEERYKK 424
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 226 ELEKL----------QNREDSSE--GIRKKLVEAEERRHSLENKVKRLETMERRENRL 271
Cdd:pfam05622 425 YVEKAksviktldpkQNPASPPEiqALKNQLLEKDKKIEHLERDFEKSKLQREQEEKL 482
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
179-626 |
5.35e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 41.44 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 179 AKLEKIN------AEQQLKIQELQEKLE---KAVKASTEATELLQNIRQAKER---AERELEKLQNREDSSEGIR-KKL- 244
Cdd:PRK11281 43 AQLDALNkqklleAEDKLVQQDLEQTLAlldKIDRQKEETEQLKQQLAQAPAKlrqAQAELEALKDDNDEETRETlSTLs 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 245 ---VEA--EERRHSLENKVKRLETM-----------ERRENRLkDDIQTKSQQIQQMADKILELEEKHREAQVSaqhlev 308
Cdd:PRK11281 123 lrqLESrlAQTLDQLQNAQNDLAEYnsqlvslqtqpERAQAAL-YANSQRLQQIRNLLKGGKVGGKALRPSQRV------ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 309 hLKQKEQHYeekikvLDNQI---KKDLADKETLENMMQRHEEEAHEKgkilseqkaminamdskIRSLEQRIVELSEAnk 385
Cdd:PRK11281 196 -LLQAEQAL------LNAQNdlqRKSLEGNTQLQDLLQKQRDYLTAR-----------------IQRLEHQLQLLQEA-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 386 laansslFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQ----NRKLEEqlekishqdhsdknRLLELETRLREVSleh 461
Cdd:PRK11281 250 -------INSKRLTLSEKTVQEAQSQDEAARIQANPLVAQeleiNLQLSQ--------------RLLKATEKLNTLT--- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 462 eEQKLELKRQLTELQLSLQERESQLTALQA----ARAALESQ--LRQAKteleeTTAEAEEEIQALTAHRDEIQRKFDAL 535
Cdd:PRK11281 306 -QQNLRVKNWLDRLTQSERNIKEQISVLKGslllSRILYQQQqaLPSAD-----LIEGLADRIADLRLEQFEINQQRDAL 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 536 RNSCTVITDLEEqlNQLTEDNAELNNQnfyLSKQLDEASGANDEIV-QLRSEvdhLRREITereMQLTsQKQTM---EAL 611
Cdd:PRK11281 380 FQPDAYIDKLEA--GHKSEVTDEVRDA---LLQLLDERRELLDQLNkQLNNQ---LNLAIN---LQLN-QQQLLsvsDSL 447
|
490 500
....*....|....*....|...
gi 767972910 612 KTTctmLEEQV--------MDLE 626
Cdd:PRK11281 448 QST---LTQQIfwvnsnkpMDLD 467
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
690-817 |
5.84e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 41.30 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 690 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 766
Cdd:PRK12704 32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 767972910 767 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 817
Cdd:PRK12704 103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
318-500 |
6.02e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 40.29 E-value: 6.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 318 EEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 397
Cdd:COG1579 23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 398 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdknrllELETRLREVSLEHEEQKLELKRQLTELQL 477
Cdd:COG1579 88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149
|
170 180
....*....|....*....|...
gi 767972910 478 SLQERESQLTALQAARAALESQL 500
Cdd:COG1579 150 ELAELEAELEELEAEREELAAKI 172
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
21-230 |
6.69e-03 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 40.99 E-value: 6.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 21 KMEQEMTRLHRRVSEVEAVLSQKEVELKA-----SETQRSLLEQ-------DLATYITEcssLKRSLEQARMEVSQ-EDD 87
Cdd:pfam06160 183 KLEEETDALEELMEDIPPLYEELKTELPDqleelKEGYREMEEEgyalehlNVDKEIQQ---LEEQLEENLALLENlELD 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 88 KALQLLHDIREQSRKLQEIKEQEYQA-------------QVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK 154
Cdd:pfam06160 260 EAEEALEEIEERIDQLYDLLEKEVDAkkyveknlpeiedYLEHAEEQNKELKEELERVQQSYTLNENELERVRGLEKQLE 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 155 RKATECQ--HKLLKAKDQGKPEVGE-----YAKLEKINAEQQlkiqELQEKLEKAVKASTEATELLQNIRQAKERAEREL 227
Cdd:pfam06160 340 ELEKRYDeiVERLEEKEVAYSELQEeleeiLEQLEEIEEEQE----EFKESLQSLRKDELEAREKLDEFKLELREIKRLV 415
|
...
gi 767972910 228 EKL 230
Cdd:pfam06160 416 EKS 418
|
|
| COG2433 |
COG2433 |
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]; |
591-732 |
7.16e-03 |
|
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 41.00 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 591 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEalnDELLEKERqweawrsvlgdeksqfecRVRELQRMLDTEKQS 670
Cdd:COG2433 398 EREKEHEERELTEEEEEIRRLEEQVERLEAEVEELE---AELEEKDE------------------RIERLERELSEARSE 456
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767972910 671 RARadqRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDLeKKHAMLEMNAR 732
Cdd:COG2433 457 ERR---EIRKDREISRL-----DREIERLERELEEERERIEELKRKLERL-KELWKLEHSGE 509
|
|
| C1_Munc13 |
cd20807 |
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ... |
959-1007 |
7.31e-03 |
|
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Pssm-ID: 410357 Cd Length: 53 Bit Score: 36.30 E-value: 7.31e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 767972910 959 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1007
Cdd:cd20807 1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
444-807 |
7.51e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 40.66 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 444 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTA 523
Cdd:COG4372 12 RLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLE-------EELEE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 524 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS 603
Cdd:COG4372 85 LNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ---LEAQIAELQSEIAEREEELKELEEQLES 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 604 QKQTMEALKTTCTMLEEQVMDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 683
Cdd:COG4372 162 LQEELAALEQELQALSEAEAE-QALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 684 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 763
Cdd:COG4372 241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL-EALEEAALELKLLALLLNLAALSLIGALEDALLA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 767972910 764 NHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 807
Cdd:COG4372 320 ALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGA 363
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
272-638 |
8.05e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 40.87 E-value: 8.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 272 KDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHE 351
Cdd:COG2770 264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLL 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 352 KGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 431
Cdd:COG2770 344 LLLAADLLLALALAALLLLLALELLLEAELLV-----------LLALEALALEAELAAVLALLAALAAALLLLELALEEL 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 432 QLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 511
Cdd:COG2770 413 VLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 512 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLR 591
Cdd:COG2770 493 EEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALL 572
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 767972910 592 REITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQ 638
Cdd:COG2770 573 LAAVAALLELAALLLLLLAAAEALAALELELAAAAEAALAEAELLEV 619
|
|
| Caldesmon |
pfam02029 |
Caldesmon; |
23-358 |
8.08e-03 |
|
Caldesmon;
Pssm-ID: 460421 [Multi-domain] Cd Length: 495 Bit Score: 40.62 E-value: 8.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 23 EQEMTRlHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYiTECSSLKRSleqarMEVSQEDDKALQLLHDIREQSRK 102
Cdd:pfam02029 4 EEEAAR-ERRRRAREERRRQKEEEEPSGQVTESVEPNEHNSY-EEDSELKPS-----GQGGLDEEEAFLDRTAKREERRQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 103 LQEIKEQEYQAQVEE--------MRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQ---HKLLKAKDQG 171
Cdd:pfam02029 77 KRLQEALERQKEFDPtiadekesVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYQENkwsTEVRQAEEEG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 172 KPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIR----QAKERAERELEKLQNREDSSEGIRKKLVEA 247
Cdd:pfam02029 157 EEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRghpeVKSQNGEEEVTKLKVTTKRRQGGLSQSQER 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 248 EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMAdkILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldnQ 327
Cdd:pfam02029 237 EEEAEVFLEAEQKLEELRRRRQEKESEEFEKLRQKQQEA--ELELEELKKKREERRKLLEEEEQRRKQEEAER------K 308
|
330 340 350
....*....|....*....|....*....|.
gi 767972910 328 IKKDlADKETLENMMQRHEEEAHEKGKILSE 358
Cdd:pfam02029 309 LREE-EEKRRMKEEIERRRAEAAEKRQKLPE 338
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
191-775 |
8.12e-03 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 40.89 E-value: 8.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 191 KIQELQeKLEKAVKASTEaTELLQNIRQakERAERELEKLQNREDS----SEGIRKKLVEAEERRHSLEN-KVKRLETME 265
Cdd:pfam07111 71 QLQELR-RLEEEVRLLRE-TSLQQKMRL--EAQAMELDALAVAEKAgqaeAEGLRAALAGAEMVRKNLEEgSQRELEEIQ 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 266 R-RENRLKDDIQTKSQQIQQMADKILELE------EKHR--------EAQVSAQHLEVHLKQKEQHYEEKIKVLDNqIKK 330
Cdd:pfam07111 147 RlHQEQLSSLTQAHEEALSSLTSKAEGLEkslnslETKRageakqlaEAQKEAELLRKQLSKTQEELEAQVTLVES-LRK 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 331 DLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISELRQ 410
Cdd:pfam07111 226 YVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRKIQ 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 411 QKFYLETQAGKleaqnrkleeqleKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTE--------------LQ 476
Cdd:pfam07111 292 PSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAElqeqvtsqsqeqaiLQ 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 477 LSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN 556
Cdd:pfam07111 359 RALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQ-------QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARI 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 557 AELNNQNFYLSKQLDEASG---ANDEIVQLRSEVDHLRREITEREMQLTSQkqtMEALKTTCTMLEEQV-MDLEALNDEL 632
Cdd:pfam07111 432 PSLSNRLSYAVRKVHTIKGlmaRKVALAQLRQESCPPPPPAPPVDADLSLE---LEQLREERNRLDAELqLSAHLIQQEV 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 633 LEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES 712
Cdd:pfam07111 509 GRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEVET 588
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767972910 713 -----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQE 775
Cdd:pfam07111 589 rlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQE 653
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
115-255 |
9.23e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 40.58 E-value: 9.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 115 VEEMRLMMNQLEEDLvsarrrSDLYESeLRESRLAAEEfkrKATECQHKLLKAKDQgKPEVGEyaKLEKINAEQQLKIQE 194
Cdd:PRK00409 504 IEEAKKLIGEDKEKL------NELIAS-LEELERELEQ---KAEEAEALLKEAEKL-KEELEE--KKEKLQEEEDKLLEE 570
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767972910 195 LQEKLEKAVKAST-EATELLQNIR-----QAKERAEREL-EKLQNREDSSEGIRKKLVEAEERRHSLE 255
Cdd:PRK00409 571 AEKEAQQAIKEAKkEADEIIKELRqlqkgGYASVKAHELiEARKRLNKANEKKEKKKKKQKEKQEELK 638
|
|
| CCCAP |
pfam15964 |
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ... |
2-292 |
9.69e-03 |
|
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.
Pssm-ID: 435040 [Multi-domain] Cd Length: 703 Bit Score: 40.66 E-value: 9.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITE----CSSLKRSLEQ 77
Cdd:pfam15964 381 EKRAQEKEALRKEMKKEREELGATMLALSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDvtkvCGEMRYQLNQ 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 78 ARMEvsqeDDKALQLLHDIREQSRKLQEIKEQEyqaqVEEMRLMMNQLEEDLVSARRRsdlyESELRESRLAAEEFKRKA 157
Cdd:pfam15964 461 TKMK----KDEAEKEHREYRTKTGRQLEIKDQE----IEKLGLELSESKQRLEQAQQD----AARAREECLKLTELLGES 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 158 TECQHKLLKAKDQGKPEVGEYAKLEKINA---EQQL--KIQELQEKLEKAV---------------KASTEATELLQNIR 217
Cdd:pfam15964 529 EHQLHLTRLEKESIQQSFSNEAKAQALQAqqrEQELtqKMQQMEAQHDKTVneqyslltsqntfiaKLKEECCTLAKKLE 608
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767972910 218 QAKERAERELEKL-QNREDSSEGIRKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILEL 292
Cdd:pfam15964 609 EITQKSRSEVEQLsQEKEYLQDRLEKLQKRNEELEEQCVQHGRMHERMKQRLRQLDKHCQATAQQLVQLLSKQNQL 684
|
|
| Lebercilin |
pfam15619 |
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ... |
394-601 |
9.75e-03 |
|
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Pssm-ID: 464776 [Multi-domain] Cd Length: 193 Bit Score: 39.12 E-value: 9.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 394 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKR 470
Cdd:pfam15619 2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767972910 471 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 550
Cdd:pfam15619 82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767972910 551 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 601
Cdd:pfam15619 141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
|
|
| |
