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Conserved domains on  [gi|767943782|ref|XP_011534512|]
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solute carrier family 22 member 16 isoform X7 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 118-394 1.04e-122

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17375:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 359.45  E-value: 1.04e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 118 GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGI 197
Cdd:cd17375    1 GNKTRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 198 AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTV 277
Cdd:cd17375   81 AVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 278 TVPFILCCWVLPetpfwllsegryeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitK 357
Cdd:cd17375  161 TIPFILCCWMLP-------------------------------------------------------------------K 173

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767943782 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLL 394
Cdd:cd17375  174 RTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLV 210
 
Name Accession Description Interval E-value
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 118-394 1.04e-122

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 359.45  E-value: 1.04e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 118 GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGI 197
Cdd:cd17375    1 GNKTRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 198 AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTV 277
Cdd:cd17375   81 AVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 278 TVPFILCCWVLPetpfwllsegryeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitK 357
Cdd:cd17375  161 TIPFILCCWMLP-------------------------------------------------------------------K 173

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767943782 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLL 394
Cdd:cd17375  174 RTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLV 210
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-393 5.91e-74

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 239.92  E-value: 5.91e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782   14 GHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVsqvvfhnhsnwsledtgALLSSGQKDYVTVQLQNG 93
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAA-----------------NLSSRCELNLTLPRLPDG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782   94 EIWELSRCSRNKRENTSSLGYEYT-----GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLG 168
Cdd:TIGR00898  64 RPESCLRFMVDQWANPSLLGCEPLklsdlGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  169 SVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHS 248
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  249 FFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFILC---CWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASscKLSEL 325
Cdd:TIGR00898 224 FFSLGLVLLPLVAYFIPDW---RWLQLAVSLPTFLFfllSWFVPESPRWLISQGRIEEALKILQRIAKINGKK--LPAEV 298

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767943782  326 LSLDLQGPVSNSPtevQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFL 393
Cdd:TIGR00898 299 LSLSLEKDLSSSK---KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFI 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
160-292 1.33e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:COG2814   53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 240 TWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC----WVLPETP 292
Cdd:COG2814  133 GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALllllRLLPESR 189
MFS_1 pfam07690
Major Facilitator Superfamily;
153-288 9.63e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 9.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  153 LAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767943782  233 FIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVL 288
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 164-316 2.01e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 49.70  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 164 GVLLGSVtfgyfSDRLGRRVVLwATSSSMFLFG-IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
Cdd:PRK03893  72 GLLLGAM-----GDRYGRRLAM-VISIVLFSVGtLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKA 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 243 SVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWV---LPETPFWLLSEGRYEEAQKIVDIMAKWNR 316
Cdd:PRK03893 146 SGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLrknLPEAEDWKEKHAGKAPVRTMVDILYRGEH 222
 
Name Accession Description Interval E-value
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 118-394 1.04e-122

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 359.45  E-value: 1.04e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 118 GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGI 197
Cdd:cd17375    1 GNKTRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 198 AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTV 277
Cdd:cd17375   81 AVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 278 TVPFILCCWVLPetpfwllsegryeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitK 357
Cdd:cd17375  161 TIPFILCCWMLP-------------------------------------------------------------------K 173

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767943782 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLL 394
Cdd:cd17375  174 RTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLV 210
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 14-393 5.91e-74

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 239.92  E-value: 5.91e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782   14 GHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVsqvvfhnhsnwsledtgALLSSGQKDYVTVQLQNG 93
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLPDAA-----------------NLSSRCELNLTLPRLPDG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782   94 EIWELSRCSRNKRENTSSLGYEYT-----GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLG 168
Cdd:TIGR00898  64 RPESCLRFMVDQWANPSLLGCEPLklsdlGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  169 SVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHS 248
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  249 FFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFILC---CWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASscKLSEL 325
Cdd:TIGR00898 224 FFSLGLVLLPLVAYFIPDW---RWLQLAVSLPTFLFfllSWFVPESPRWLISQGRIEEALKILQRIAKINGKK--LPAEV 298

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767943782  326 LSLDLQGPVSNSPtevQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFL 393
Cdd:TIGR00898 299 LSLSLEKDLSSSK---KQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFI 363
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 128-393 1.39e-59

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 197.03  E-value: 1.39e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 128 GYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYT 207
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 208 FMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWV 287
Cdd:cd17317   81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 288 LPetpfwllsegryeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWF 367
Cdd:cd17317  161 LP-------------------------------------------------------------------RRTIIVGLIWF 173

                        250       260
                 ....*....|....*....|....*.
gi 767943782 368 TGSLGFYSFSLNSVNLGGNEYLNLFL 393
Cdd:cd17317  174 VTSLVYYGLSLNSSNLGGNLYLNFFL 199
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 124-289 4.99e-37

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 137.81  E-value: 4.99e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17374    7 PCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFIL 283
Cdd:cd17374   87 TFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFL 166


                 ....*.
gi 767943782 284 CCWVLP 289
Cdd:cd17374  167 YSWWLP 172
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 124-289 9.79e-31

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 120.61  E-value: 9.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17447    7 PCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFIL 283
Cdd:cd17447   87 SYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGII 166


                 ....*.
gi 767943782 284 CCWVLP 289
Cdd:cd17447  167 TWWWVP 172
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 124-393 9.28e-30

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 117.95  E-value: 9.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17376    7 PCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT-WASVHLHSFFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFI 282
Cdd:cd17376   87 SWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRIlFSTLGVCIFYAIGYMLLPLFAYFIRDW---RMLLLALTLPGV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 283 LCcwvlpeTPFWllsegryeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynWSITKRTLTV 362
Cdd:cd17376  164 LC------VPLW----------------------------------------------------------WFIPITTIMS 179

                        250       260       270
                 ....*....|....*....|....*....|.
gi 767943782 363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFL 393
Cdd:cd17376  180 LLLWMAISVGYFGLSLNTPNLHGDPYLNCFL 210
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 124-295 1.44e-29

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 117.52  E-value: 1.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17446    5 PCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFIL 283
Cdd:cd17446   85 SFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFL 164

                        170
                 ....*....|..
gi 767943782 284 CCWVLPETPFWL 295
Cdd:cd17446  165 YSWWFPRITFCL 176
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 124-296 7.48e-29

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 115.53  E-value: 7.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNtwKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17379    7 PCQDGWVYNTP--RSSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSP 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFIL 283
Cdd:cd17379   85 NYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLL 164

                        170
                 ....*....|...
gi 767943782 284 CCWVLPETPFWLL 296
Cdd:cd17379  165 YYWFIPKHTFILM 177
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 141-393 1.23e-18

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 86.76  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 141 VTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVAS 220
Cdd:cd17377   28 VSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 221 GYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPetpfwllsegr 300
Cdd:cd17377  108 GMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP----------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 301 yeeaqkivdimakwnrasscklsellsldlqgpvsnsptevqkhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSLNS 380
Cdd:cd17377  177 --------------------------------------------------------GRTLILMYVWFVCSLVYYGLTLNA 200

                        250
                 ....*....|...
gi 767943782 381 VNLGGNEYLNLFL 393
Cdd:cd17377  201 GDLGGNIYLNLAL 213
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 124-289 6.39e-16

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 78.28  E-value: 6.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 124 PCVDGYIYDQNTW-KSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFA 202
Cdd:cd17443    7 LCTGGWPFSAAAGlGSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 203 VDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMiLSTVTVPFI 282
Cdd:cd17443   87 ASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQG-VGTLPLLLL 165


                 ....*..
gi 767943782 283 LCCWVLP 289
Cdd:cd17443  166 LLYWCFP 172
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 125-284 3.08e-15

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 76.35  E-value: 3.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 125 CVDGYIY-DQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV 203
Cdd:cd17445    8 CDAGWNYtGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 204 DYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVhLHSFFAVGTLLVALTGYLVRTWWlyQMILSTVTVPFIL 283
Cdd:cd17445   88 SPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAM-AGGLTMVGGHFLLLGLALGCGSW--RVLQGTITAPLSL 164


                 .
gi 767943782 284 C 284
Cdd:cd17445  165 F 165
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 137-288 5.70e-15

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 75.47  E-value: 5.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 137 KSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSD-RLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFL 215
Cdd:cd17378   18 KVSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLT 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943782 216 AMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVL 288
Cdd:cd17378   98 GFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSSWRVLYFWTSIPALIYCILVYL 170
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 163-306 1.21e-14

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 75.30  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 163 FGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
Cdd:cd17358   52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767943782 243 SVHLHSFFAVGTLLVALTGYLVRtWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQK 306
Cdd:cd17358  132 GSLNQLLVNIGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEK 194
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
160-292 1.33e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 74.63  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:COG2814   53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 240 TWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC----WVLPETP 292
Cdd:COG2814  133 GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALllllRLLPESR 189
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 140-290 2.89e-14

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 73.71  E-value: 2.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 140 AVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVA 219
Cdd:cd17373   13 AVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943782 220 SGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPE 290
Cdd:cd17373   93 AGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFPK 163
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 162-264 4.78e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.02  E-value: 4.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 162 MFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
Cdd:cd17316   46 FLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGF 125

                         90       100
                 ....*....|....*....|...
gi 767943782 242 ASVHLHSFFAVGTLLVALTGYLV 264
Cdd:cd17316  126 ALGLLQSGWALGALLAALVASLL 148
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
160-297 1.66e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.28  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:COG2271   53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKER 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767943782 240 TWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVlpetPFWLLS 297
Cdd:COG2271  133 GRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----RFWLLA 186
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 156-296 2.35e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 64.06  E-value: 2.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 156 LIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235
Cdd:COG0477   53 WIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFP 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943782 236 MKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILsTVTVPFILCCWVL----PETPFWLL 296
Cdd:COG0477  133 ARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF-LINAPLGLLALVLrlrlPESRGLLL 196
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 162-400 3.19e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 64.69  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  162 MFGVLLGSVTFGYFSDRLGR-RVVLWatssSMFLFGI---AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMK 237
Cdd:TIGR00895  62 LIGMAFGALFFGPLADRIGRrRVLLW----SILLFSVftlLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  238 SRTWASVHLHSFFAVGTLLVA-LTGYLV-----RTWWLYQMILSTVTVPFILccWVLPETPFWLLSEgRYEEAQKIVDIM 311
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGfLAGWLIpvfgwRSLFYVGGIAPLLLLLLLM--RFLPESIDFLVSK-RPETVRRIVNAI 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  312 AKWNRASScklseLLSLDLQGPVSNSPTEVQKhnlsyLFYNWSITKRTLTVWLIWFTGSLGFYsfSLNS------VNLGG 385
Cdd:TIGR00895 215 APQMQAEA-----QSALPEQKSTQGTKRSVFK-----ALFQGKTARITVLLWLLYFMLLVGVY--FLTNwlpklmVELGF 282

                         250
                  ....*....|....*
gi 767943782  386 NEYLNLFLLETLYFG 400
Cdd:TIGR00895 283 SLSLAATGGALFNFG 297
MFS_1 pfam07690
Major Facilitator Superfamily;
153-288 9.63e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 9.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  153 LAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767943782  233 FIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVL 288
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 143-291 1.73e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 59.09  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 143 QWNLvcdRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGY 222
Cdd:cd17372   28 EWNL---SAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGG 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943782 223 LVVGFVYvMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLV--RTWWLYQMILSTV-TVPFILCCWVLPET 291
Cdd:cd17372  105 PQLASWY-LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVmpRLGWRWLLAFSSVpSSLLLVFYRWTPKT 175
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 160-292 1.81e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 59.13  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWAtssSMFLFGIA---AAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGM 236
Cdd:cd17320   42 AYLLGFALGQLLYGPLSDRFGRRPVLLA---GLLLFILAsllCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSG 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 237 KSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTV----PFILCCWVLPETP 292
Cdd:cd17320  119 AELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALlgllLLLLVLLFLPETL 178
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 160-263 6.26e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 57.17  E-value: 6.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:cd17324   42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKR 121

                         90       100
                 ....*....|....*....|....*
gi 767943782 240 TWASVHLHSFFAVGTLL-VALTGYL 263
Cdd:cd17324  122 GRAIGLVFSGLTLGLVLgRPLGGLL 146
Sugar_tr pfam00083
Sugar (and other) transporter;
160-307 6.94e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 57.67  E-value: 6.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVD---YYTFMAARFFLAMVASGYLVVGFVYVMEFIGM 236
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782  237 KSRTWASVHLHSFFAVGTLLVALTGYLVRT------WWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKI 307
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREV 210
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 152-282 8.67e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 56.80  E-value: 8.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 152 WLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTF---MAARFFLAMVASGYLVVGFV 228
Cdd:cd17478  230 VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYillVLAGFLLFASFPVTVVLAQE 309

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767943782 229 YVMEFIGMKSrtwaSVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFI 282
Cdd:cd17478  310 LLPGNVGLAS----GLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLL 359
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 125-283 1.11e-08

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 56.40  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 125 CVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVD 204
Cdd:cd17444    9 CTERDYRIRAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVN 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767943782 205 YYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWwlyQMILSTVTVPFIL 283
Cdd:cd17444   89 VTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDW---QVLQAVIICPFLL 164
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 160-292 1.15e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWAtssSMFLFGIAA---AFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGM 236
Cdd:cd17325   39 AYALAQLLFSPPAGRLSDRFGRKRLLLL---GLLLLAVSTllfAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPP 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 237 KSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQM--ILSTV--TVPFILCCWVLPETP 292
Cdd:cd17325  116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRApfLVCAAlaLLALVLALLLLPEPR 175
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 138-300 1.54e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 56.16  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 138 STAVTQWNLvcDRKWLAMLIQPLFMFGVLlGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAM 217
Cdd:cd17371   23 PALIAEFGL--DEAEAGLLGTVTLAGGAI-GGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 218 VASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTW------WLYQMILStvTVPFILCCWV---L 288
Cdd:cd17371  100 GFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeiaWRVLFLLG--ALPALLVLFIrrfV 177

                        170
                 ....*....|..
gi 767943782 289 PETPFWLLSEGR 300
Cdd:cd17371  178 KEPPQWQAARAA 189
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 152-378 5.23e-08

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 54.98  E-value: 5.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  152 WLAMLIqplfMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVM 231
Cdd:TIGR01299 206 MLGLIV----YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  232 EFIGMKSRTWASVHLHSFFAVGTLLVAL----------------TGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
Cdd:TIGR01299 282 EFLAQEKRGEHLSWLCMFWMIGGIYAAAmawaiiphygwsfqmgSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFF 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSL----------DLQGPVSNSPTEVQK---HNLSYLF---------YNW 353
Cdd:TIGR01299 362 LENGKHDEAWMILKLIHDTNMRAKGHPEKVFSVnhiktihqedELIEIESDTGTWYQRcfvRALSEGGgiwgnflrcFNP 441

                         250       260
                  ....*....|....*....|....*
gi 767943782  354 SITKRTLTVWLIWFTGSLGFYSFSL 378
Cdd:TIGR01299 442 EVREITIKLMGVWFTLSFGYYGLSV 466
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 161-308 7.20e-08

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 54.19  E-value: 7.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 161 FMFGVLLGSVTFGYFSDRLGRRVVLwATSSSMFLFG----IAAAFAVDYYTFMAARfFLAMVASGyLVVGFV--YVMEFI 234
Cdd:cd17357   58 FFIGGAIGSFISAFLANRFGRKNGL-LISNALLVVSsllmFLSKSAKSPELLIFGR-FLVGIACG-LSTGFVpmYLQEIS 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 235 GMKSRTWASVHLHSFFAVGTLLVALTGY-----LVRTWWLyqmILSTVTVPFILCC---WVLPETPFWLL-SEGRYEEAQ 305
Cdd:cd17357  135 PSELRGALGSLTQIGVTLGILLGQVFGLpsvlgTETLWPY---LLFFPGIPALLQLaalPFFPESPKFLLiSKGDEEEAE 211


                 ...
gi 767943782 306 KIV 308
Cdd:cd17357  212 KSL 214
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
154-261 7.94e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 54.09  E-value: 7.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 154 AMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEf 233
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA- 123

                         90       100
                 ....*....|....*....|....*...
gi 767943782 234 IGMKSRTWASVHLHSFFAVGTLLVALTG 261
Cdd:COG0738  124 LGPETAASRLNLLHAFFSLGALLGPLLG 151
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 162-301 1.08e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 53.34  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 162 MFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
Cdd:cd17359   46 LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGR 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943782 242 ASVHLHSFFAVGTLLVALTGYLVRTW----WLYQMI----LSTVTVP---FILCCWVLPETPFWLLSEGRY 301
Cdd:cd17359  126 LVSLNQLMIVFGQLLAYIVNYLIANAggadWLGAEGwrwmLGLEAIPailFLLGMLFIPESPRWLVSKGKP 196
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 153-400 1.24e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.20  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 153 LAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 233 FIGMKSRTWASVHLHSFFAVGTLLVALTGYLV--RTWWLYQMILSTVTVPFILCCwvlpeTPFWLLSEGRYEEAQKivdi 310
Cdd:cd06174  112 LFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAA-----ILLLLVVPDPPESARA---- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 311 makwnrasscklsellsldlqgPVSNSPTEVQKHNLSYLFYNwsitKRTLTVWLIWFTGSLGFYSFSLnsvnlggneYLN 390
Cdd:cd06174  183 ----------------------KNEEASSKSVLKLLKRVLKN----PGLWLLLLAIFLVNLAYYSFST---------LLP 227

                        250
                 ....*....|
gi 767943782 391 LFLLETLYFG 400
Cdd:cd06174  228 LFLLDLGGLS 237
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 156-292 1.98e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 52.71  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 156 LIQPLFMFGVLLGSVTFGYFSDRLGRRVVLwATSSSMFLFGIAAAFAV-DYYTFMAARFFLAMVASGYLVVGFVYVMEFI 234
Cdd:cd17333   35 VIFSSQNAGYLIGSLLAGFLMKRLGRRRTL-ILGLLLISLALALIFATpSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943782 235 GMKSRTWASVhLHSFFAVG-TLLVALTGYLVRT---WWLYQMILSTVTVPFILcCWVLPETP 292
Cdd:cd17333  114 EESSATRLNV-LHGFFGLGaLIGPLIATSLLTSelsWSWAYLIIGLIYLLLAI-LILLTLFP 173
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 163-378 2.85e-07

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 52.34  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 163 FGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
Cdd:cd17439   45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 243 SVHLHSFFAVGTLLVAL----------------TGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQK 306
Cdd:cd17439  125 LSWLCMFWMIGGIYASAmawaiiphygwsfqmgSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWM 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943782 307 IVDIMAKWNRASSCKLSELLSLdlqgpvsnspTEVQKhnlsylfynwsitKRTLTVWLIWFTGSLGFYSFSL 378
Cdd:cd17439  205 VLKQVHDTNMRAKGHPERVFSV----------THIKR-------------RITLMMMAVWFTMSFSYYGLTV 253
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 163-308 5.72e-07

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 51.46  E-value: 5.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 163 FGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
Cdd:cd17438   45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 243 SVHLHSFFAVGTLLVAL----------------TGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQK 306
Cdd:cd17438  125 LSWLCMFWMIGGLYASAmawsiiphygwgfsmgTNYHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWM 204


                 ..
gi 767943782 307 IV 308
Cdd:cd17438  205 IL 206
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 160-369 9.98e-07

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 50.80  E-value: 9.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  160 LFMFGVLLGSVTFGYFSDRLGRRVVLWAtSSSMFLFG----IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIG 235
Cdd:TIGR00879  79 IFLVGGFIGALFAGWLSDRFGRKKSLLI-IALLFVIGailmGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAP 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  236 MKSRTWASVHLHSFFAVGTLLVALTGYLVRTW-----WLYqMILSTVTVPFILCCWV--LPETPFWLLSEGRYEEAQKIV 308
Cdd:TIGR00879 158 KALRGALTSLYQLAITFGILVAYGFGSGKVSLnntlgWRI-PLGLQLIPAGLLFLGLffLPESPRWLVGKGRVEEARKSL 236

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943782  309 dimAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLF-----YNWSITKRTLTVWLIWFTG 369
Cdd:TIGR00879 237 ---ARLRGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSLFsstrrIRRRLFLGVVLQWFQQFTG 299
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 153-290 1.01e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 50.65  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 153 LAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232
Cdd:cd17323   35 VANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIAD 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767943782 233 FIGMKSRTWASvhlhSFFAVGTLLVA-----LTGYLVRTW---WLY--QMILSTVTvpFILCCWVLPE 290
Cdd:cd17323  115 LFTPEERGKAM----GVYSLGPLLGPalgpiIGGFITQSLgwrWIFwfLAIISGFC--LILIFLFLPI 176
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 149-308 1.28e-06

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 50.57  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 149 DRKWLAMLIqplfMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFV 228
Cdd:cd17363   35 NKGMLGLIV----YLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 229 YVMEFIGMKSRTWASVHLHSFFAVGTLLVAL----------------TGYLVRTWWLYQMILSTVTVPFILCCWVLPETP 292
Cdd:cd17363  111 YFAEFLAREKRGEHLSWLCMFWMIGGLYASAmawaiiphygwgfsmgTAYQFHSWRVFVIVCALPSVASVVALTFMPESP 190

                        170
                 ....*....|....*.
gi 767943782 293 FWLLSEGRYEEAQKIV 308
Cdd:cd17363  191 RFLLEVGKHDEAWMIL 206
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 162-263 1.44e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 162 MFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW 241
Cdd:cd17365   44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123

                         90       100
                 ....*....|....*....|..
gi 767943782 242 ASVHLHSFFAVGTllvALTGYL 263
Cdd:cd17365  124 AVTLMFCGYPLGA---ALGGFL 142
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 164-316 2.01e-06

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 49.70  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 164 GVLLGSVtfgyfSDRLGRRVVLwATSSSMFLFG-IAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA 242
Cdd:PRK03893  72 GLLLGAM-----GDRYGRRLAM-VISIVLFSVGtLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKA 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 243 SVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWV---LPETPFWLLSEGRYEEAQKIVDIMAKWNR 316
Cdd:PRK03893 146 SGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLrknLPEAEDWKEKHAGKAPVRTMVDILYRGEH 222
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 143-291 2.43e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 49.43  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 143 QWNLvcdRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGY 222
Cdd:cd17441   28 EWRL---PSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGV 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943782 223 LVVGFVYVmEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTW--WLYQMILSTVTVPF--ILCCWvLPET 291
Cdd:cd17441  105 PQSVTLYA-EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTlgWRWLLILSALPLLIfaVLCFW-LPES 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
160-253 1.22e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:COG2814  251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330

                         90
                 ....*....|....
gi 767943782 240 TWASVHLHSFFAVG 253
Cdd:COG2814  331 GRASGLYNSAFFLG 344
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 161-292 1.24e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 47.18  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 161 FMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARfFLAMVASGyLVVGFV--YVMEFIGMKS 238
Cdd:cd17315   43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR-FLLGLGVG-LASVLVplYISEIAPAKI 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 239 RTwASVHLHSFFA-VGTLLVALTGYLV--RTWWLYQMILSTVTVP---FILCCWVLPETP 292
Cdd:cd17315  121 RG-ALGTLNQLMItFGILLAYLLGLALslSPPGWWRLMFALAAVPallQLLLMFFLPESR 179
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 152-378 1.40e-05

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 47.21  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 152 WLAMLIqplfMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVM 231
Cdd:cd17440   38 WLGSIV----YLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 232 EFIGMKSRTWASVHLHSFFAVGTLLVAL----------------TGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWL 295
Cdd:cd17440  114 EVLAREKRGEHLSWLCMFWMIGGIYASAmawaiiphygwsfsmgSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 296 LSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDlqgpvsnsptEVQKHNlsylfynwsitkrTLTVWLIWFTGSLGFYS 375
Cdd:cd17440  194 LEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVN----------RIKKDN-------------TIKLTIVWLTLSFGYYG 250


                 ...
gi 767943782 376 FSL 378
Cdd:cd17440  251 LSV 253
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
160-288 1.66e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRR--VVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMK 237
Cdd:COG2271  224 LPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767943782 238 SR-TWASVHLHSFFAVGTLLVALTGYLVRTWWlYQMILSTVTVPFILCCWVL 288
Cdd:COG2271  304 ARgTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLA 354
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 152-265 1.98e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 152 WLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVL----WATSSSMFLFGIAAAFAVdyytFMAARFFLAMVaSGYLVVGF 227
Cdd:cd17330   34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLllslAGSAVSYVLLGLSRNLWL----LFLARFLDGLT-GGNVSVAQ 108

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767943782 228 VYVMEFIGMKSRTWASVHLHSFFAVGTLL-VALTGYLVR 265
Cdd:cd17330  109 AYIADITDEEERAKAFGIISAAFGLGFILgPALGGFLST 147
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
160-283 4.16e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSR 239
Cdd:COG2223   48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767943782 240 TWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFIL 283
Cdd:COG2223  128 GLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLV 171
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 160-267 5.83e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.87  E-value: 5.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLwatSSSMFLFGIAA---AFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGM 236
Cdd:cd17319   46 AFFLGYALFQVPGGWLLDRFGARKVL---AVSMLLWSLFTaltGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPA 122

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767943782 237 KSRTWASVHLHSFFAVGTLLVA-LTGYLVRTW 267
Cdd:cd17319  123 RERGRATGLFNSGAPLGAAIGPpLSGWLLLLF 154
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 162-213 1.75e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.41  E-value: 1.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943782 162 MFGVLLGSVTFGYFSDRLGRRVVLWAtssSMFLFG---IAAAFAVDYYTFMAARF 213
Cdd:PRK11551  60 ILGLLPGALLGGRLADRIGRKRILIV---SVALFGlfsLATAQAWDFPSLLVARL 111
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 160-291 2.74e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 42.76  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782  160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME-FIGMKS 238
Cdd:TIGR00710  48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDiYPGEEL 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782  239 RTWASVhLHSFFAVGTLLVALTGYLVRTWWLYQMILSTV----TVPFILCCWVLPET 291
Cdd:TIGR00710 128 SRIYSI-LMPVLALAPAVAPLLGGYILVWLSWHAIFAFLslagILLSALIFFILPET 183
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 143-264 3.09e-04

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 42.87  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 143 QWNLvcdRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGY 222
Cdd:cd17442   30 EWHL---EDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGH 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767943782 223 lVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLV 264
Cdd:cd17442  107 -SQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVV 147
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 152-292 6.57e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 6.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 152 WLAMLIQPLFMFGVLLGSVTfGYFSDRLGRRVVLWAtssSMFLFGIA---AAFAVDYYTFMAARFFLAMVASGYLVVGFV 228
Cdd:cd17474   35 QVGLLITAFTLPAAVLMPVA-GVLADRFGRKKVLLP---GLLLFGIGgllCGLSDSFALLLAGRALQGIGAAGLGPLALT 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 229 YVMEFIGMKSRTWASVHLHSFFAVGTLLV-ALTGYLVRTWWLYQMILSTVTVPFILCCWV--LPETP 292
Cdd:cd17474  111 LIGDLFEGGERAKAMGLYEAALGLGIAVGpLLGGLLAAISWRYPFFLLAALIPVAFLAILflLPEPK 177
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 152-285 1.11e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 152 WLAMLIQPLFMFGVLLGSVTFGYFSDR-LGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYV 230
Cdd:cd06174  239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767943782 231 MEFIGMKSRTwasvHLHSFFAVGTLLVALTGYLVRTWWLYQMIlsTVTVPFILCC 285
Cdd:cd06174  319 AELFPPEIRG----TAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLA 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
154-239 1.19e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.02  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 154 AMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAV-DYYTFMAARFFLAMVASGYLVVGFVYVME 232
Cdd:COG2223  243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPD 322


                 ....*..
gi 767943782 233 FIGMKSR 239
Cdd:COG2223  323 IFPTKNA 329
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 162-294 6.13e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 38.49  E-value: 6.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943782 162 MFGVLLGSVTFGYFSDRLGRRVVLwATSSSMFLFG-IAAAFAVDYYTFMAARFF------LAMVASGylvvgfVYVMEFI 234
Cdd:cd17362   49 LLGALLGSLVAGALIDRLGRRKEL-ILAALLYLVGsLVTGLAPSYPVLLVGRLIygvgigLAMHAAP------VYIAETS 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943782 235 GMKSRTWASVHLHSFFAVGTLLVALTGYLVRT---WWLYqMILSTVTVPFILCC--WVLPETPFW 294
Cdd:cd17362  122 PSHIRGLLVSLKELFIVLGILLGYVSGYAFADvvgGWRY-MYGLAAPPALLLGIgmWFLPPSPRW 185
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 160-216 7.13e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 7.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767943782 160 LFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLA 216
Cdd:cd17477  231 AFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW 287
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 163-215 7.81e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 7.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767943782 163 FGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFL 215
Cdd:cd17473   46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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