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Conserved domains on  [gi|767977613|ref|XP_011533355|]
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general transcription factor IIF subunit 2 isoform X3 [Homo sapiens]

Protein Classification

general transcription factor IIF subunit 2( domain architecture ID 10168383)

general transcription factor IIF subunit 2 (GTF2F2) is a subunit of TFIIF, which is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-103 1.67e-29

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


:

Pssm-ID: 259828  Cd Length: 123  Bit Score: 103.18  E-value: 1.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977613   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100
                 ....*....|....*....|..
gi 767977613  82 PFVLQSVGGQTLTVFTESSSGG 103
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPG 92
 
Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-103 1.67e-29

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


Pssm-ID: 259828  Cd Length: 123  Bit Score: 103.18  E-value: 1.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977613   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100
                 ....*....|....*....|..
gi 767977613  82 PFVLQSVGGQTLTVFTESSSGG 103
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPG 92
TFIIF_beta_N pfam17683
TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general ...
 15-105 1.70e-20

TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 465458  Cd Length: 104  Bit Score: 79.70  E-value: 1.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977613   15 NTGVWLVKVPKYLSQQWAKA---SGRGEVGKLRIAKT---QGRTEVSFTLNEDLANIHDIggkpasvsaPREHPFVLQSV 88
Cdd:pfam17683   1 NSKVWLVKVPKFLWEKWSKPdddNEGIELGTLRVYKNpdpGGKQRVKLKLNDDLPQHENI---------PKEYNLDVTNT 71

                          90
                  ....*....|....*..
gi 767977613   89 GGQTLTVFTESSSGGSR 105
Cdd:pfam17683  72 RVQNTYVFSEKDLPGFK 88
TFG2 COG5090
Transcription initiation factor IIF, small subunit (RAP30) [Transcription];
6-74 2.86e-03

Transcription initiation factor IIF, small subunit (RAP30) [Transcription];


Pssm-ID: 227421 [Multi-domain]  Cd Length: 297  Bit Score: 36.10  E-value: 2.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767977613   6 ELDLTGAKQNTGVWLVKVPKYLSQQWakASGRGEVGKLRIAKTQGRTEVSFTLNedLANIHDIGGKPAS 74
Cdd:COG5090   19 DADLDLNNRHTKVWLVKVPLFLAEKW--LSREAEIGELLGTKRTSTDPAVISLL--LSNEFCNGGFPSS 83
 
Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-103 1.67e-29

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


Pssm-ID: 259828  Cd Length: 123  Bit Score: 103.18  E-value: 1.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977613   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100
                 ....*....|....*....|..
gi 767977613  82 PFVLQSVGGQTLTVFTESSSGG 103
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPG 92
TFIIF_beta_N pfam17683
TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general ...
 15-105 1.70e-20

TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 465458  Cd Length: 104  Bit Score: 79.70  E-value: 1.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977613   15 NTGVWLVKVPKYLSQQWAKA---SGRGEVGKLRIAKT---QGRTEVSFTLNEDLANIHDIggkpasvsaPREHPFVLQSV 88
Cdd:pfam17683   1 NSKVWLVKVPKFLWEKWSKPdddNEGIELGTLRVYKNpdpGGKQRVKLKLNDDLPQHENI---------PKEYNLDVTNT 71

                          90
                  ....*....|....*..
gi 767977613   89 GGQTLTVFTESSSGGSR 105
Cdd:pfam17683  72 RVQNTYVFSEKDLPGFK 88
TFG2 COG5090
Transcription initiation factor IIF, small subunit (RAP30) [Transcription];
6-74 2.86e-03

Transcription initiation factor IIF, small subunit (RAP30) [Transcription];


Pssm-ID: 227421 [Multi-domain]  Cd Length: 297  Bit Score: 36.10  E-value: 2.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767977613   6 ELDLTGAKQNTGVWLVKVPKYLSQQWakASGRGEVGKLRIAKTQGRTEVSFTLNedLANIHDIGGKPAS 74
Cdd:COG5090   19 DADLDLNNRHTKVWLVKVPLFLAEKW--LSREAEIGELLGTKRTSTDPAVISLL--LSNEFCNGGFPSS 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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