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Conserved domains on  [gi|767977611|ref|XP_011533354|]
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general transcription factor IIF subunit 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-144 7.67e-34

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


:

Pssm-ID: 259828  Cd Length: 123  Bit Score: 119.35  E-value: 7.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767977611  82 PFVLQSVGGQTLTVFTESSSGGSRMTAGVTTVISTSqaskgkqdgeDKLSLEGIVVQRAECRP 144
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPGFKARSQPYYRKSIP----------KKTALEGRVVHECDCRP 123
TFIIF_beta pfam02270
TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general ...
 202-266 5.70e-33

TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


:

Pssm-ID: 426691  Cd Length: 65  Bit Score: 115.02  E-value: 5.70e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977611  202 ARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR 266
Cdd:pfam02270   1 ARMPRNELLDALFSLFEEHQYWSLKDLRERTRQPEAYLKETLEEIAVLNRSGPFAGMWELKPEYR 65
 
Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-144 7.67e-34

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


Pssm-ID: 259828  Cd Length: 123  Bit Score: 119.35  E-value: 7.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767977611  82 PFVLQSVGGQTLTVFTESSSGGSRMTAGVTTVISTSqaskgkqdgeDKLSLEGIVVQRAECRP 144
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPGFKARSQPYYRKSIP----------KKTALEGRVVHECDCRP 123
TFIIF_beta pfam02270
TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general ...
 202-266 5.70e-33

TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 426691  Cd Length: 65  Bit Score: 115.02  E-value: 5.70e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977611  202 ARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR 266
Cdd:pfam02270   1 ARMPRNELLDALFSLFEEHQYWSLKDLRERTRQPEAYLKETLEEIAVLNRSGPFAGMWELKPEYR 65
TFG2 COG5090
Transcription initiation factor IIF, small subunit (RAP30) [Transcription];
6-273 1.39e-31

Transcription initiation factor IIF, small subunit (RAP30) [Transcription];


Pssm-ID: 227421 [Multi-domain]  Cd Length: 297  Bit Score: 118.53  E-value: 1.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   6 ELDLTGAKQNTGVWLVKVPKYLSQQWAkaSGRGEVGKLRIAKTQGRTEVSFTLNedLANIHDIGGKPASVSAPREHPFVL 85
Cdd:COG5090   19 DADLDLNNRHTKVWLVKVPLFLAEKWL--SREAEIGELLGTKRTSTDPAVISLL--LSNEFCNGGFPSSYDLKIKPKDVN 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611  86 QSVggqtltVFTESSSGGSrmtagvttvistsqaskgkqdgEDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPV 165
Cdd:COG5090   95 NYY------VFRESETSTH----------------------EKNTAVVGTVNHECYVTPEVNDEYLRYKQDRGFKSDSKK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611 166 RLSQQLD--KVVTTNYKPVANHQYNIEYERKKKE----DGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYL 239
Cdd:COG5090  147 SDVQVIDylKGGKRGEKFGSLRSSTLEFLARKRKkmlmDKKRERLPKNEVLDMLFKAFEKYPYWTLKGLAEFCGQPEAFL 226

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767977611 240 KEILKEIGVQNVKGIHKNTWELKPEYRHYQGEEK 273
Cdd:COG5090  227 KEILDDIAVLNKKGPYANKYELRPEYKQTMDELR 260
TFIIF_beta_N pfam17683
TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general ...
 15-145 1.42e-19

TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 465458  Cd Length: 104  Bit Score: 81.24  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   15 NTGVWLVKVPKYLSQQWAKA---SGRGEVGKLRIAKT---QGRTEVSFTLNEDLANIHDIggkpasvsaPREHPFVLQSV 88
Cdd:pfam17683   1 NSKVWLVKVPKFLWEKWSKPdddNEGIELGTLRVYKNpdpGGKQRVKLKLNDDLPQHENI---------PKEYNLDVTNT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767977611   89 GGQTLTVFTESSSGGSrmtagvttvistsqaskgkqdgedKLSLEGIVVQRAECRPA 145
Cdd:pfam17683  72 RVQNTYVFSEKDLPGF------------------------KANLAGRVVHECNVRPV 104
 
Name Accession Description Interval E-value
TFIIF_beta cd07980
Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA ...
 5-144 7.67e-34

Transcription initiation factor IIF, beta subunit; The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.


Pssm-ID: 259828  Cd Length: 123  Bit Score: 119.35  E-value: 7.67e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   5 GELDLTGAKQNtgVWLVKVPKYLSQQWAKASGRG-EVGKLRIAKTQ--GRTEVSFTLNEDLANIHDIggkpasvsaPREH 81
Cdd:cd07980    2 LDLDTSNADRS--VWLVKVPKFLSERWSKLDDDGiELGTLRVYKDPpsGKPRVSLTLPENLPENANI---------PKEY 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767977611  82 PFVLQSVGGQTLTVFTESSSGGSRMTAGVTTVISTSqaskgkqdgeDKLSLEGIVVQRAECRP 144
Cdd:cd07980   71 ELDMTNESVQNTYVFSEKDLPGFKARSQPYYRKSIP----------KKTALEGRVVHECDCRP 123
TFIIF_beta pfam02270
TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general ...
 202-266 5.70e-33

TFIIF, beta subunit HTH domain; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 426691  Cd Length: 65  Bit Score: 115.02  E-value: 5.70e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767977611  202 ARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR 266
Cdd:pfam02270   1 ARMPRNELLDALFSLFEEHQYWSLKDLRERTRQPEAYLKETLEEIAVLNRSGPFAGMWELKPEYR 65
TFG2 COG5090
Transcription initiation factor IIF, small subunit (RAP30) [Transcription];
6-273 1.39e-31

Transcription initiation factor IIF, small subunit (RAP30) [Transcription];


Pssm-ID: 227421 [Multi-domain]  Cd Length: 297  Bit Score: 118.53  E-value: 1.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   6 ELDLTGAKQNTGVWLVKVPKYLSQQWAkaSGRGEVGKLRIAKTQGRTEVSFTLNedLANIHDIGGKPASVSAPREHPFVL 85
Cdd:COG5090   19 DADLDLNNRHTKVWLVKVPLFLAEKWL--SREAEIGELLGTKRTSTDPAVISLL--LSNEFCNGGFPSSYDLKIKPKDVN 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611  86 QSVggqtltVFTESSSGGSrmtagvttvistsqaskgkqdgEDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPV 165
Cdd:COG5090   95 NYY------VFRESETSTH----------------------EKNTAVVGTVNHECYVTPEVNDEYLRYKQDRGFKSDSKK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611 166 RLSQQLD--KVVTTNYKPVANHQYNIEYERKKKE----DGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYL 239
Cdd:COG5090  147 SDVQVIDylKGGKRGEKFGSLRSSTLEFLARKRKkmlmDKKRERLPKNEVLDMLFKAFEKYPYWTLKGLAEFCGQPEAFL 226

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767977611 240 KEILKEIGVQNVKGIHKNTWELKPEYRHYQGEEK 273
Cdd:COG5090  227 KEILDDIAVLNKKGPYANKYELRPEYKQTMDELR 260
TFIIF_beta_N pfam17683
TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general ...
 15-145 1.42e-19

TFIIF, beta subunit N-terminus; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit of TFIIF is required for recruitment of RNA polymerase II onto the promoter.


Pssm-ID: 465458  Cd Length: 104  Bit Score: 81.24  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977611   15 NTGVWLVKVPKYLSQQWAKA---SGRGEVGKLRIAKT---QGRTEVSFTLNEDLANIHDIggkpasvsaPREHPFVLQSV 88
Cdd:pfam17683   1 NSKVWLVKVPKFLWEKWSKPdddNEGIELGTLRVYKNpdpGGKQRVKLKLNDDLPQHENI---------PKEYNLDVTNT 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767977611   89 GGQTLTVFTESSSGGSrmtagvttvistsqaskgkqdgedKLSLEGIVVQRAECRPA 145
Cdd:pfam17683  72 RVQNTYVFSEKDLPGF------------------------KANLAGRVVHECNVRPV 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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