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Conserved domains on  [gi|767977487|ref|XP_011533312|]
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forkhead box protein O1 isoform X2 [Homo sapiens]

Protein Classification

FOXO family forkhead box protein( domain architecture ID 11245002)

FOXO family forkhead box protein functions as a transcription factor, similar to forkhead box protein O4 (FOXO4), also called Fork head domain transcription factor AFX1, that is involved in the regulation of the insulin signaling pathway that binds to insulin-response elements (IREs) and can activate transcription of IGFBP1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
 186-267 1.79e-25

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


:

Pssm-ID: 465228  Cd Length: 80  Bit Score: 98.65  E-value: 1.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977487  186 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 264
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77


                  ...
gi 767977487  265 SVM 267
Cdd:pfam16675  78 SVM 80
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
 360-396 1.51e-16

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


:

Pssm-ID: 435506  Cd Length: 40  Bit Score: 72.75  E-value: 1.51e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767977487  360 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 396
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38
 
Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
 186-267 1.79e-25

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


Pssm-ID: 465228  Cd Length: 80  Bit Score: 98.65  E-value: 1.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977487  186 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 264
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77


                  ...
gi 767977487  265 SVM 267
Cdd:pfam16675  78 SVM 80
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
 360-396 1.51e-16

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


Pssm-ID: 435506  Cd Length: 40  Bit Score: 72.75  E-value: 1.51e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767977487  360 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 396
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38
 
Name Accession Description Interval E-value
FOXO_KIX_bdg pfam16675
KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of ...
 186-267 1.79e-25

KIX-binding domain of forkhead box O, CR2; FOXO_KIX_bd is the first part of the region of transcription factor forkhead box O family proteins that binds to the CREB-binding proteins via the KIX domain. Coactivator CBP/p300 is recruited by FOXO3 via the binding of this domain as well as the simultaneous binding of the more C-terminal TAD domain.


Pssm-ID: 465228  Cd Length: 80  Bit Score: 98.65  E-value: 1.79e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767977487  186 KYTYGQSSMSPLPQMPIQTLQDNK-SSYGGMSQYNcAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVmmGPN 264
Cdd:pfam16675   1 KSIYGQPSMNSLRQMPMQTIQENKqSSFGSMSQYG-PAGLLQELLTSDSYPHSDILTQVDPLMSQASGRVLSQNH--RQN 77


                  ...
gi 767977487  265 SVM 267
Cdd:pfam16675  78 SVM 80
FOXO-TAD pfam16676
Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that ...
 360-396 1.51e-16

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.


Pssm-ID: 435506  Cd Length: 40  Bit Score: 72.75  E-value: 1.51e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767977487  360 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 396
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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