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Conserved domains on  [gi|767938612|ref|XP_011532947|]
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zinc finger protein 354A isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-31 3.41e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.45  E-value: 3.41e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767938612     1 MLENYRNLVSLGLPFTKPKVISLLQQGEDPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-558 5.24e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 156 QNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYICKEC 233
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 234 GKAFTLSTSLYKHLRTHT---VEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPG--------------------R 290
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSssvntpqsnslhpplpanslS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 291 KASSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRC 370
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 371 NECGKGFTSISRLNRHRIIHTGE-------KFYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFRQSS 437
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 438 ALIQHQRMHTGERPYKCNEC-------GKTFRCNSSLSNHQRIHTGEKPYRCE--ECGISFGQSSALIQHRRIHTGEKP- 507
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767938612 508 -FKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGklFNHRSSLTNHYKIH 558
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-31 3.41e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.45  E-value: 3.41e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767938612     1 MLENYRNLVSLGLPFTKPKVISLLQQGEDPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-558 5.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 156 QNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYICKEC 233
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 234 GKAFTLSTSLYKHLRTHT---VEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPG--------------------R 290
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSssvntpqsnslhpplpanslS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 291 KASSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRC 370
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 371 NECGKGFTSISRLNRHRIIHTGE-------KFYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFRQSS 437
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 438 ALIQHQRMHTGERPYKCNEC-------GKTFRCNSSLSNHQRIHTGEKPYRCE--ECGISFGQSSALIQHRRIHTGEKP- 507
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767938612 508 -FKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGklFNHRSSLTNHYKIH 558
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNHGKD 467
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 422-474 6.69e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 6.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767938612 422 KPcKCKVCGKAFRQSSALIQHQRMHTgerpYKCNECGKTFRCNSSLSNH-QRIH 474
Cdd:cd20908    1 KP-WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-351 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  326 SLRYHQRIHTGEKPFKCSECGRAFSQ 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-31 3.41e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 61.45  E-value: 3.41e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767938612     1 MLENYRNLVSLGLPFTKPKVISLLQQGEDPW 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
156-558 5.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 156 QNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEKLFKC--KECSKAFSQSSALIQHQITHTGEKPYICKEC 233
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 234 GKAFTLSTSLYKHLRTHT---VEKSYRCKECGKSFSRRSGLFIHQKIHAEENPCKYNPG--------------------R 290
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSssvntpqsnslhpplpanslS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 291 KASSCSTSLSGCQRIHSRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRC 370
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 371 NECGKGFTSISRLNRHRIIHTGE-------KFYNCNECGKALSSHSTLIIHER--IHTGE--KPCKCKV--CGKAFRQSS 437
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 438 ALIQHQRMHTGERPYKCNEC-------GKTFRCNSSLSNHQRIHTGEKPYRCE--ECGISFGQSSALIQHRRIHTGEKP- 507
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPy 417

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767938612 508 -FKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGklFNHRSSLTNHYKIH 558
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK--SFRRDLDLSNHGKD 467
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 422-474 6.69e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 6.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767938612 422 KPcKCKVCGKAFRQSSALIQHQRMHTgerpYKCNECGKTFRCNSSLSNH-QRIH 474
Cdd:cd20908    1 KP-WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-351 1.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  326 SLRYHQRIHTGEKPFKCSECGRAFSQ 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-463 3.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  438 ALIQHQRMHTGERPYKCNECGKTFRC 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-379 3.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  354 SLIQHERIHTGEKPYRCNECGKGFTS 379
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
242-267 4.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  242 SLYKHLRTHTVEKSYRCKECGKSFSR 267
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 338-386 4.94e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 4.94e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767938612 338 KPFkCSECGRAFSQSASLIQHERIHTgekpYRCNECGKGFTSISRLNRH 386
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-519 6.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 767938612  494 ALIQHRRIHTGEKPFKCNTCGKTFRQ 519
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 165-251 6.46e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 165 KITADKRYKCSL--CEKTFINTSSLRKHEKNhsgeklfkcKECSKAFSQSSALIQHQITHTGEKPYICKECGKAFTLSTS 242
Cdd:COG5189  343 KVKDGKPYKCPVegCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNG 413


                 ....*....
gi 767938612 243 LYKHlRTHT 251
Cdd:COG5189  414 LKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
309-559 9.77e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 309 KKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRA--FSQSASLIQHERIHTGEKPYRCN--------------- 371
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 372 ------------ECGKGFTSISRLNRHRIIHTGEKFYNC------------------------NECGKALSSHSTLIIHE 415
Cdd:COG5048  111 sssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 416 RIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSAL 495
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767938612 496 IQHRRIHTGE-------KPFKCNTCGKTFRQSSSRIAHQR--IHTGE--KPYEC--NTCGKLFNHRSSLTNHYKIHI 559
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-211 2.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 767938612  186 SLRKHEKNHSGEKLFKCKECSKAFSQ 211
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 420-499 2.50e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 420 GEKPCKCKV--CGKAFRQSSALIQHqRMHtgerpykcNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSALIQ 497
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 767938612 498 HR 499
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 310-387 2.57e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938612 310 KSYLCN--ECGNTFKSSSSLRYHqRIHtgekpfkcSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHR 387
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 256-278 3.07e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.07e-03
                          10        20
                  ....*....|....*....|...
gi 767938612  256 YRCKECGKSFSRRSGLFIHQKIH 278
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-489 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|....
gi 767938612  466 SLSNHQRIHTGEKPYRCEECGISF 489
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
526-547 5.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.34e-03
                          10        20
                  ....*....|....*....|..
gi 767938612  526 HQRIHTGEKPYECNTCGKLFNH 547
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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