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Conserved domains on  [gi|767922694|ref|XP_011531804|]
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sterol regulatory element-binding protein cleavage-activating protein isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 697-854 1.81e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 1.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 697 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 773
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 774 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 849
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 767922694 850 DLLQT 854
Cdd:cd00200  168 KCVAT 172
Sterol-sensing super family cl48133
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 3-71 4.28e-23

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


The actual alignment was detected with superfamily member pfam12349:

Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 96.50  E-value: 4.28e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922694    3 GLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 71
Cdd:pfam12349  77 ALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 COG2319
WD40 repeat [General function prediction only];
512-854 1.07e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 512 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 591
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 592 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 667
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 668 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 732
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 733 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 808
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 767922694 809 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 854
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 24-152 3.13e-05

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 47.74  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694   24 IGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIdirrMELADLNKRLPPEACLPSakpvgQPTRYERQLAVRPST 103
Cdd:pfam02460 340 IGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI----CAKPEAEGRHCLFVWATS-----SPQRIDSEGSEPDKS 410

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767922694  104 PHTITLQPSSFRNLRLPkrlrvvyFLARTRLaqRLIMAGT-VVWIGILVY 152
Cdd:pfam02460 411 HNIEQLKSRFFLDIYCP-------FLLNPSV--RVCMLVLfVVYIAIAIY 451
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-421 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767922694   390 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 421
Cdd:smart00320   7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 697-854 1.81e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 1.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 697 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 773
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 774 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 849
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 767922694 850 DLLQT 854
Cdd:cd00200  168 KCVAT 172
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 3-71 4.28e-23

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 96.50  E-value: 4.28e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922694    3 GLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 71
Cdd:pfam12349  77 ALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 COG2319
WD40 repeat [General function prediction only];
512-854 1.07e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 512 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 591
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 592 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 667
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 668 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 732
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 733 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 808
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 767922694 809 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 854
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
591-854 4.90e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 4.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 591 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 670
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 671 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 736
Cdd:COG2319   81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 737 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 812
Cdd:COG2319  161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767922694 813 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 854
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 727-765 1.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767922694   727 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 765
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 24-152 3.13e-05

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 47.74  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694   24 IGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIdirrMELADLNKRLPPEACLPSakpvgQPTRYERQLAVRPST 103
Cdd:pfam02460 340 IGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI----CAKPEAEGRHCLFVWATS-----SPQRIDSEGSEPDKS 410

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767922694  104 PHTITLQPSSFRNLRLPkrlrvvyFLARTRLaqRLIMAGT-VVWIGILVY 152
Cdd:pfam02460 411 HNIEQLKSRFFLDIYCP-------FLLNPSV--RVCMLVLfVVYIAIAIY 451
WD40 pfam00400
WD domain, G-beta repeat;
730-765 5.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767922694  730 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 765
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 23-85 8.64e-05

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 46.44  E-value: 8.64e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922694    23 LIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMEladlNKRLPPEACLPSAK 85
Cdd:TIGR00917  709 ALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE----DKRVDCFPCIKTSK 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-421 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767922694   390 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 421
Cdd:smart00320   7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 390-432 2.59e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767922694 390 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 432
Cdd:cd00200  214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 697-854 1.81e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 1.81e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 697 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 773
Cdd:cd00200    8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 774 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 849
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                 ....*
gi 767922694 850 DLLQT 854
Cdd:cd00200  168 KCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 586-854 3.08e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 3.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 586 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLEThtalsp 661
Cdd:cd00200    9 TGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLET------ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 662 lqfrgtpgrgsspaspvysssdtvaCHLTHTVPCaHQKPITALKAAAGR--LVTGSQDHTLRVFRLEDSCCLFTLQGHSG 739
Cdd:cd00200   83 -------------------------GECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 740 AITTVYIDQT-MVLASGGQDGAICLWDVLTGSRVsHVF-AHRGDVTSLTC--TTSCVISSGLDDLISIWDRSTGIKFYSI 815
Cdd:cd00200  137 WVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCV-ATLtGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 767922694 816 QQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 854
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGseDGTIRVWDLRTGECVQT 256
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 3-71 4.28e-23

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 96.50  E-value: 4.28e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922694    3 GLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 71
Cdd:pfam12349  77 ALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 COG2319
WD40 repeat [General function prediction only];
512-854 1.07e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 512 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 591
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 592 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 667
Cdd:COG2319   84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 668 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 732
Cdd:COG2319  162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 733 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 808
Cdd:COG2319  241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 767922694 809 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 854
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 595-805 1.30e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 1.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 595 QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKR--IVAARLNGSLDFFSLETHTALSPLQFRGTPGRG- 671
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSv 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 672 -SSPASPVYSSS---------DTVACHLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSG 739
Cdd:cd00200  142 aFSPDGTFVASSsqdgtiklwDLRTGKCVATLT-GHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922694 740 AITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTC--TTSCVISSGLDDLISIWD 805
Cdd:cd00200  221 GVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
591-854 4.90e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 4.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 591 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 670
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 671 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 736
Cdd:COG2319   81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 737 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 812
Cdd:COG2319  161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767922694 813 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 854
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
586-808 3.39e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 3.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 586 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLETHTALSP 661
Cdd:COG2319  162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 662 LqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA-GR-LVTGSQDHTLRVFRLE 726
Cdd:COG2319  242 L--TGHSGSVRSVAfSPdgrllASGSADGTVRlwdlatgELLRTLT-GHSGGVNSVAFSPdGKlLASGSDDGTVRLWDLA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 727 DSCCLFTLQGHSGAITTVYI---DQTmvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLI 801
Cdd:COG2319  319 TGKLLRTLTGHTGAVRSVAFspdGKT--LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTV 396


                 ....*..
gi 767922694 802 SIWDRST 808
Cdd:COG2319  397 RLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
578-766 2.25e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 2.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 578 SLAWAPsaegsiwslelQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLET 655
Cdd:COG2319  209 SVAFSP-----------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 656 HTALSPLqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTL 720
Cdd:COG2319  278 GELLRTL--TGHSGGVNSVAfSPdgkllASGSDDGTVRlwdlatgKLLRTLT-GHTGAVRSVAFSPdgKTLASGSDDGTV 354

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 767922694 721 RVFRLEDSCCLFTLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDV 766
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFspDGRT-LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 730-854 4.08e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 4.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 730 CLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDR 806
Cdd:cd00200    1 LRRTLKGHTGGVTCVaFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767922694 807 STGIKFYSIQQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 854
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKTIKVWDVETGKCLTT 130
WD40 COG2319
WD40 repeat [General function prediction only];
688-855 2.93e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 688 HLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDV 766
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694 767 LTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVS 842
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgKLLASGSDdGTVR 187

                        170
                 ....*....|...
gi 767922694 843 FWDLNYGDLLQTV 855
Cdd:COG2319  188 LWDLATGKLLRTL 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 727-765 1.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.14e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767922694   727 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 765
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 24-152 3.13e-05

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 47.74  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694   24 IGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIdirrMELADLNKRLPPEACLPSakpvgQPTRYERQLAVRPST 103
Cdd:pfam02460 340 IGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI----CAKPEAEGRHCLFVWATS-----SPQRIDSEGSEPDKS 410

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767922694  104 PHTITLQPSSFRNLRLPkrlrvvyFLARTRLaqRLIMAGT-VVWIGILVY 152
Cdd:pfam02460 411 HNIEQLKSRFFLDIYCP-------FLLNPSV--RVCMLVLfVVYIAIAIY 451
WD40 pfam00400
WD domain, G-beta repeat;
730-765 5.48e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.48e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767922694  730 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 765
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 23-85 8.64e-05

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 46.44  E-value: 8.64e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922694    23 LIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMEladlNKRLPPEACLPSAK 85
Cdd:TIGR00917  709 ALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE----DKRVDCFPCIKTSK 767
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-421 1.44e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767922694   390 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 421
Cdd:smart00320   7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 390-432 2.59e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 2.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767922694 390 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 432
Cdd:cd00200  214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
10-110 3.41e-03

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 41.41  E-value: 3.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922694    10 SIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMEladlNKRLPPEACL--PSAKPV 87
Cdd:TIGR00918  505 SVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRRE----DRRLDIFCCFfsPCSARV 580

                           90       100
                   ....*....|....*....|....*.
gi 767922694    88 GQ--PTRYERQLAVRPSTPH-TITLQ 110
Cdd:TIGR00918  581 IQiePQAYADGSAPPVYSSHmQSTVQ 606
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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