F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767913862 299 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 345
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767913862 299 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 345
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

transcriptional regulator ICP4; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913862  123 SCSGGPQREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGaPEDSGPGGLGT-------- 194
Cdd:PHA03307  191 AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG-PENECPLPRPApitlptri 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913862  195 -RAQAANGGSERSQPPRSSGLRRQAIQNWQR---------RPRRHSTEGEEGDVSDVGSRTTESEAEGPLdAPRPGPAMA 264
Cdd:PHA03307  270 wEASGWNGPSSRPGPASSSSSPRERSPSPSPsspgsgpapSSPRASSSSSSSRESSSSSTSSSSESSRGA-AVSPGPSPS 348

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767913862  265 GPLSSCRLSARPEGGS-GRGRRAERVSPSRSNEVISPEILKMRAAL 309
Cdd:PHA03307  349 RSPSPSRPPPPADPSSpRKRPRPSRAPSSPAASAGRPTRRRARAAV 394

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767913862 299 SPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 345
Cdd:cd22109    1 SLESLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767913862 300 PEILKMraalfcIFTYLDTRTLLHAAEVCRDWRFVARHPAVW 341
Cdd:cd22125    5 PEILAM------IFSYLDVRDKGRAAQVCTAWRDAAYHKSVW 40

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 767913862 309 LFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVL 345
Cdd:cd22132    9 LLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELF 45

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20
                 ....*....|....*....|....*...
gi 767913862 309 LFCIFTYLDTRTLLHAAEVCRDWRFVAR 336
Cdd:cd09917    8 LLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767913862 300 PEILKMRaalfcIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTR 343
Cdd:cd22147    6 PVELSLK-----ILSYLDAKSLCRAAQVSKKWRNLADDDELWKR 44

transcriptional regulator ICP4; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913862  123 SCSGGPQREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGaPEDSGPGGLGT-------- 194
Cdd:PHA03307  191 AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG-PENECPLPRPApitlptri 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767913862  195 -RAQAANGGSERSQPPRSSGLRRQAIQNWQR---------RPRRHSTEGEEGDVSDVGSRTTESEAEGPLdAPRPGPAMA 264
Cdd:PHA03307  270 wEASGWNGPSSRPGPASSSSSPRERSPSPSPsspgsgpapSSPRASSSSSSSRESSSSSTSSSSESSRGA-AVSPGPSPS 348

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767913862  265 GPLSSCRLSARPEGGS-GRGRRAERVSPSRSNEVISPEILKMRAAL 309
Cdd:PHA03307  349 RSPSPSRPPPPADPSSpRKRPRPSRAPSSPAASAGRPTRRRARAAV 394

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 767913862 312 IFTYLDTRTLLHAAEVCRDWRFVARHPAVWT 342
Cdd:cd22173   14 IFSFLDPRSLCRAAQVSWHWKFLAEQDCLWM 44

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 767913862 308 ALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTR 343
Cdd:cd22137    7 PMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWRN 42

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 767913862 312 IFTYLDTRTLLHAAEVCRDWR-FVARHPAVW 341
Cdd:cd22113   12 IFSQLDVQSLCRASQTCKTWNdLIENSDYLW 42

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|
gi 767913862 312 IFTYLDTRTLLHAAEVCRDWRFVARHPAVW 341
Cdd:cd22094   14 IFSYLDPRSLCRAAQVSWYWKFLCESDELW 43

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 767913862 312 IFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRV 344
Cdd:cd22134   15 IFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRI 47