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Conserved domains on  [gi|768017997|ref|XP_011527281|]
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zinc finger protein 335 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-601 2.09e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.09e-05
                          10        20
                  ....*....|....*....|....*.
gi 768017997  576 RLTQHMKTHSTEKPHMCDKCGKSFKK 601
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
523-546 2.14e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 2.14e-04
                          10        20
                  ....*....|....*....|....
gi 768017997  523 YKCDECSYTSVYRKDVIRHAAVHS 546
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 2.60e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 768017997  509 SLKEHMFNHVGSKPYKCDECSYTSVY 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|...
gi 768017997  562 FPCPVCGRVYPMQKRLTQHMKTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
245-265 7.93e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 7.93e-03
                          10        20
                  ....*....|....*....|.
gi 768017997  245 FKCKMCQYRSSTKATLLRHMR 265
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLR 21
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-601 2.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.09e-05
                          10        20
                  ....*....|....*....|....*.
gi 768017997  576 RLTQHMKTHSTEKPHMCDKCGKSFKK 601
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
523-546 2.14e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 2.14e-04
                          10        20
                  ....*....|....*....|....
gi 768017997  523 YKCDECSYTSVYRKDVIRHAAVHS 546
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 2.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 768017997  509 SLKEHMFNHVGSKPYKCDECSYTSVY 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|...
gi 768017997  562 FPCPVCGRVYPMQKRLTQHMKTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
245-265 7.93e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 7.93e-03
                          10        20
                  ....*....|....*....|.
gi 768017997  245 FKCKMCQYRSSTKATLLRHMR 265
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLR 21
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
576-601 2.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.09e-05
                          10        20
                  ....*....|....*....|....*.
gi 768017997  576 RLTQHMKTHSTEKPHMCDKCGKSFKK 601
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
523-546 2.14e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 39.07  E-value: 2.14e-04
                          10        20
                  ....*....|....*....|....
gi 768017997  523 YKCDECSYTSVYRKDVIRHAAVHS 546
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 2.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 768017997  509 SLKEHMFNHVGSKPYKCDECSYTSVY 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 590-612 8.39e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.39e-04
                          10        20
                  ....*....|....*....|...
gi 768017997  590 HMCDKCGKSFKKRYTFKMHLLTH 612
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 562-584 5.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|...
gi 768017997  562 FPCPVCGRVYPMQKRLTQHMKTH 584
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
245-265 7.93e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 7.93e-03
                          10        20
                  ....*....|....*....|.
gi 768017997  245 FKCKMCQYRSSTKATLLRHMR 265
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLR 21
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
562-584 9.30e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 34.53  E-value: 9.30e-03
                          10        20
                  ....*....|....*....|...
gi 768017997  562 FPCPVCGRVYPMQKRLTQHMKTH 584
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSH 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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