|
Name |
Accession |
Description |
Interval |
E-value |
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
45-298 |
4.21e-98 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 316.06 E-value: 4.21e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 45 LHPPYFNLAEGARIAASATCGEEAPargsprpteDLYCKLVGGPvaggdpnqtiRGQYCDICTAANSNKAHPASNAIDGT 124
Cdd:pfam00055 1 CYPAFGNLAFGREVSATSTCGLNGP---------ERYCILSGLE----------GGKKCFICDSRDPHNSHPPSNLTDSN 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 125 ER----WWQSPPLSrgLEYNEVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSMDFGRTYQPWQFFASskrDCLERFG 200
Cdd:pfam00055 62 NGtnetWWQSETGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDFGKTWQPYQYFAS---DCRRTFG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 201 -PQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLmgkaLR 279
Cdd:pfam00055 136 rPSGPSRGIKDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDEL----LD 211
|
250
....*....|....*....
gi 768017173 280 DPTVTRRYYYSIKDISIGG 298
Cdd:pfam00055 212 DPSVLRKYYYAISDISVGG 230
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
44-298 |
4.15e-94 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 305.05 E-value: 4.15e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 44 SLHPPYFNLAEGARIAASATCGEEAPARgsprptedlYCKLVGGpvaggdpnqTIRGQYCDICTAANSNKAHPASNAIDG 123
Cdd:smart00136 6 SCYPPFVNLAFGREVTATSTCGEPGPER---------YCKLVGH---------TEQGKKCDYCDARNPRRSHPAENLTDG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 124 TE----RWWQSPPLSRGLEYneVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSmDFGRTYQPWQFFASskrDCLERF 199
Cdd:smart00136 68 NNpnnpTWWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERS-DFGKTWQPWQYFSS---DCRRTF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 200 GPQTLERITR--DDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKA 277
Cdd:smart00136 141 GRPPRGPITKgnEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDR 220
|
250 260
....*....|....*....|.
gi 768017173 278 lrdPTVTRRYYYSIKDISIGG 298
Cdd:smart00136 221 ---PEVTRRYYYAISDIAVGG 238
|
|
| Laminin_I |
pfam06008 |
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ... |
2101-2359 |
4.48e-94 |
|
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 305.88 E-value: 4.48e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2101 LRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEAT 2180
Cdd:pfam06008 1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2181 LGHAKTLLAAIRAVDRTLSELMSQTGHLGLaNASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLAR 2260
Cdd:pfam06008 81 LGHAKELAEAIKNLIDNIKEINEKVATLGE-NDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2261 VQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLH 2340
Cdd:pfam06008 160 IQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLK 239
|
250
....*....|....*....
gi 768017173 2341 AARDTLASVFRLLHSLDQA 2359
Cdd:pfam06008 240 TARDSLDAANLLLQEIDDA 258
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
1602-1738 |
5.00e-48 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 168.99 E-value: 5.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1602 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVfvPMESRPDVVLQGNQMSITFLEPA--YPTPGHVHRGQLQLVEGNFR 1679
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPDqpPPDPGQEQTYSVRLHEENWR 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 1680 HTeTRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVE 1738
Cdd:pfam00052 79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
|
|
| LamB |
smart00281 |
Laminin B domain; |
1598-1727 |
2.04e-44 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 158.19 E-value: 2.04e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1598 FPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVpmeSRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGN 1677
Cdd:smart00281 2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1678 FRHTETRnTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASP 1727
Cdd:smart00281 79 WQYYGGR-PVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
2550-2671 |
2.38e-40 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 146.86 E-value: 2.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2550 DTATRVQSQLQAMQENVERWQGQYEGLRGQ---------DLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLa 2620
Cdd:pfam06009 10 ETAKEVLEQLAPLSQNLENTSEKLSGINRSleetnelvnDANKALDDAGRSVKKLEELAPDLLDKLKPLKQLEVNSSSL- 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 2621 lSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADLAAYTAL 2671
Cdd:pfam06009 89 -SDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3254-3411 |
4.33e-28 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 112.51 E-value: 4.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3254 SYQFGGSlsSHLEFVGiLARHRNWPSLSMHVLPRSSRGLLLFTARlRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQR 3333
Cdd:cd00110 1 GVSFSGS--SYVRLPT-LPAPRTRLSISFSFRTTSPNGLLLYAGS-QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 3334 SRPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGaehPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLH 3411
Cdd:cd00110 77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3435-3585 |
9.79e-26 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.58 E-value: 9.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3435 GLFFPGSGGViTLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGefSTSVTRPSVL 3514
Cdd:cd00110 1 GVSFSGSSYV-RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 3515 CDGQWHRLAVMKSGNVLRLEVD-AQSNHTVGPLLAAAAGAPAPLYLGGLPEPMAV--QPWPPAYCGCMRRLAVN 3585
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDgERVVESGSPGGSALLNLDGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
3279-3413 |
1.74e-25 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 104.34 E-value: 1.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3279 SLSMHVLPRSSRGLLLFTARlRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRS-RPGRWHKVSVRWEKNRILLVTDG 3357
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGS-KGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPlNDGQWHRVAVERNGRSVTLSVDG 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 3358 ARAWSQEGPhRQHQGAEHPQPhtLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGR 3413
Cdd:smart00282 80 GNRVSGESP-GGLTILNLDGP--LYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3286-3413 |
1.62e-22 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 95.56 E-value: 1.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3286 PRSSRGLLLFTARLRpgSPSLALFLSNGHFVAQME-GLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQE 3364
Cdd:pfam02210 3 TRQPNGLLLYAGGGG--SDFLALELVNGRLVLRYDlGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 768017173 3365 GPHRQHQgaeHPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGR 3413
Cdd:pfam02210 81 PPGESLL---LNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
|
|
| LamG |
smart00282 |
Laminin G domain; |
3459-3586 |
1.62e-21 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 92.79 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3459 LELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVlCDGQWHRLAVMKSGNVLRLEVDAQ 3538
Cdd:smart00282 2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL-NDGQWHRVAVERNGRSVTLSVDGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 3539 SN-HTVGPLLAAAAGAPAPLYLGGLPEPM--AVQPWPPAYCGCMRRLAVNR 3586
Cdd:smart00282 81 NRvSGESPGGLTILNLDGPLYLGGLPEDLklPPLPVTPGFRGCIRNLKVNG 131
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3463-3585 |
8.85e-20 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 87.86 E-value: 8.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3463 VRPLAVTGLIFHLGQARTPpYLQLQVTEKQVLLRADDGAGEFSTSVTrPSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHT 3542
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 768017173 3543 VGPLLAAAAGAPAPL-YLGGLPEP--MAVQPWPPAYCGCMRRLAVN 3585
Cdd:pfam02210 79 SLPPGESLLLNLNGPlYLGGLPPLllLPALPVRAGFVGCIRDVRVN 124
|
|
| LamG |
smart00282 |
Laminin G domain; |
2690-2817 |
1.67e-15 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 75.84 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2690 FVMYMGSRQaTGDYMGVSLRDKKVHWVYQLGeAGPAVLSIDEDI---GeQFAAVSLDRTLQFGHMSVTVERQMIQETkgd 2766
Cdd:smart00282 14 LLLYAGSKG-GGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPlndG-QWHRVAVERNGRSVTLSVDGGNRVSGES--- 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 2767 tvaPGAEGLLNLrpdDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEE 2817
Cdd:smart00282 88 ---PGGLTILNL---DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2256-2528 |
9.35e-15 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 81.52 E-value: 9.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATL 2335
Cdd:COG1196 249 EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2336 QATLHAARDTLAsvfRLLHSLDQAKEELERLAASLDGARTPLLQRmqtfspAGSKLRLVEAAEAHAQQLGQLALNLSSII 2415
Cdd:COG1196 329 EEELEELEEELE---ELEEELEEAEEELEEAEAELAEAEEALLEA------EAELAEAEEELEELAEELLEALRAAAELA 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2416 LDVNQDRLTQRAIEASNAysRILQAVQAAEDAAGQALQQADHTwatvvrQGLVDRAQQLLANSTALEEAMLQEQQRLGlv 2495
Cdd:COG1196 400 AQLEELEEAEEALLERLE--RLEEELEELEEALAELEEEEEEE------EEALEEAAEEEAELEEEEEALLELLAELL-- 469
|
250 260 270
....*....|....*....|....*....|...
gi 768017173 2496 wAALQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG1196 470 -EEAALLEAALAELLEELAEAAARLLLLLEAEA 501
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2852-3004 |
2.99e-14 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 72.84 E-value: 2.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2852 GSYLDGTGFARISFDSQISTTKRFEQELRLVSYSGVLFFL--KQQSQFLCLAVQEGSLVLLYDFGAGlkkAVPLQPPPPL 2929
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSG---SLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2930 -TSASKAIQVFLLGgsrKRVLVRVER---ATVYSVEQDNDLELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIK 3004
Cdd:cd00110 78 nDGQWHSVSVERNG---RSVTLSVDGervVESGSPGGSALLNLDGPLYLGGLPEDLKSPGL----PVSPGFVGCIRDLK 149
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2115-2604 |
7.86e-14 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 78.29 E-value: 7.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2115 HRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAV 2194
Cdd:pfam01576 183 NKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNA 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2195 DRTLSELMSQTGHL--GLANasapsgEQLLRTLAEVERllwemraRDLGAPQAAAEAELAAAQRLLArVQEQLSSLWEE- 2271
Cdd:pfam01576 263 LKKIRELEAQISELqeDLES------ERAARNKAEKQR-------RDLGEELEALKTELEDTLDTTA-AQQELRSKREQe 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2272 ----NQALATQTRdrlaQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAlqrKQELSRDNATLQATlhaardtla 2347
Cdd:pfam01576 329 vtelKKALEEETR----SHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKA---KQALESENAELQAE--------- 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2348 svfrlLHSLDQAKEELERLAASLDGArtplLQRMQTFSPAGSKLRlVEAAEahaqQLGQLALNLSSI--ILDVNQDRLTQ 2425
Cdd:pfam01576 393 -----LRTLQQAKQDSEHKRKKLEGQ----LQELQARLSESERQR-AELAE----KLSKLQSELESVssLLNEAEGKNIK 458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2426 RAIEASNAYSRiLQAVQaaedaagQALQQadhtwatvvrqglvdRAQQLLANSTALEEAmlqEQQRLGLvwaalqgaRTQ 2505
Cdd:pfam01576 459 LSKDVSSLESQ-LQDTQ-------ELLQE---------------ETRQKLNLSTRLRQL---EDERNSL--------QEQ 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2506 LRDVRAKKDQLEAHIQAAQAMLAmdtdETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRG------Q 2579
Cdd:pfam01576 505 LEEEEEAKRNVERQLSTLQAQLS----DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKtknrlqQ 580
|
490 500 510
....*....|....*....|....*....|.
gi 768017173 2580 DLGQAVLDAGHS---VSTLEK---TLPQLLA 2604
Cdd:pfam01576 581 ELDDLLVDLDHQrqlVSNLEKkqkKFDQMLA 611
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1347-1395 |
1.61e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 67.38 E-value: 1.61e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1347 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDC 1395
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2082-2645 |
1.79e-13 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 76.73 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2082 LLLDDLERAGALLPAIHEQLRGINAssmawARLHRLNASIADLQSQ---LRSPLGPRHETAQQLEVLEQQSTSLGQDARR 2158
Cdd:COG4717 46 MLLERLEKEADELFKPQGRKPELNL-----KELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2159 LggqavgtrDQASQLLAgteatlghaktLLAAIRAVDRTLSELMSQTghlglanasapsgEQLLRTLAEVERLLWEMRAR 2238
Cdd:COG4717 121 L--------EKLLQLLP-----------LYQELEALEAELAELPERL-------------EELEERLEELRELEEELEEL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2239 DlgapqaaaeaelaaaqRLLARVQEQLSSLWEEnqaLATQTRDRLAqheaglmDLREALNRAVDATREAQELNSRNQERL 2318
Cdd:COG4717 169 E----------------AELAELQEELEELLEQ---LSLATEEELQ-------DLAEELEELQQRLAELEEELEEAQEEL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2319 EEALQRKQELSRD--NATLQATLHAARdTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEA 2396
Cdd:COG4717 223 EELEEELEQLENEleAAALEERLKEAR-LLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2397 AEAHAQQLGQLALNLSSIILdvnQDRLTQRAIEASNAYSRILQAVQAAEDAAgQALQQADHTWATVVRQGLVDRAQQLLA 2476
Cdd:COG4717 302 KEAEELQALPALEELEEEEL---EELLAALGLPPDLSPEELLELLDRIEELQ-ELLREAEELEEELQLEELEQEIAALLA 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2477 NSTALEEAMLQEqqrlglvWAALQGARTQLR-DVRAKKDQLEAHIQAAQAMLAMDTDETskkiahakavaaeAQDTATRV 2555
Cdd:COG4717 378 EAGVEDEEELRA-------ALEQAEEYQELKeELEELEEQLEELLGELEELLEALDEEE-------------LEEELEEL 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2556 QSQLQAMQENVERWQGQYEGLRGQdlgQAVLDAGHSVSTLEKTLPQLLAKLSILENRgvhNASLALsasigrVRELIAQA 2635
Cdd:COG4717 438 EEELEELEEELEELREELAELEAE---LEQLEEDGELAELLQELEELKAELRELAEE---WAALKL------ALELLEEA 505
|
570
....*....|
gi 768017173 2636 RGAASKVKVP 2645
Cdd:COG4717 506 REEYREERLP 515
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1486-1534 |
2.68e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.61 E-value: 2.68e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1486 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1534
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| LamG |
smart00282 |
Laminin G domain; |
2874-3008 |
4.46e-13 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 68.91 E-value: 4.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2874 RFEQELRLVSYSGVLFFL--KQQSQFLCLAVQEGSLVLLYDFGAGLKKAVPlQPPPPLTSASKAIQVFLLGgsrKRVLVR 2951
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNG---RSVTLS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2952 V---ERATVYSVEQDNDLELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIKALGK 3008
Cdd:smart00282 77 VdggNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPL----PVTPGFRGCIRNLKVNGK 132
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
540-583 |
2.38e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.91 E-value: 2.38e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 768017173 540 PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL 583
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
587-634 |
5.76e-12 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 62.76 E-value: 5.76e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQAGSC 634
Cdd:pfam00053 1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1978-2024 |
6.38e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 6.38e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1978 PCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQ--GCR 2024
Cdd:cd00055 1 PCDCnGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQggGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1485-1535 |
6.70e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 6.70e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 1485 PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSlDAANPKGCT 1535
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1979-2023 |
1.25e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 61.94 E-value: 1.25e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 1979 CACGPA-AEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGC 2023
Cdd:smart00180 1 CDCDPGgSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1346-1388 |
1.30e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 61.99 E-value: 1.30e-11
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 768017173 1346 PCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1388
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2084-2532 |
1.43e-11 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 70.57 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2084 LDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQ---LRSPLGPRHETAQQLEVLEQQSTSLGQDARRLG 2160
Cdd:COG4717 104 LEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERleeLEERLEELRELEEELEELEAELAELQEELEELL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2161 GQ-AVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRT----LAEVERLLWEM 2235
Cdd:COG4717 184 EQlSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllLIAAALLALLG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2236 RARDLGAPQAAAEAELAAAQRLLA-----RVQEQLSSLWEENQALATQTRDRLAQHEagLMDLREALNRAVDATREAQEL 2310
Cdd:COG4717 264 LGGSLLSLILTIAGVLFLVLGLLAllfllLAREKASLGKEAEELQALPALEELEEEE--LEELLAALGLPPDLSPEELLE 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2311 NSRNQERLEEALQRKQELSRdnatlQATLHAARDTLASVFRLLHSLDqaKEELERLAAsldgartpLLQRMQtfspagsk 2390
Cdd:COG4717 342 LLDRIEELQELLREAEELEE-----ELQLEELEQEIAALLAEAGVED--EEELRAALE--------QAEEYQ-------- 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2391 lRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAysriLQAVQAAEDAAGQALQQADHTWATVVRQGLVDR 2470
Cdd:COG4717 399 -ELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEE----LEELEEELEELREELAELEAELEQLEEDGELAE 473
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 2471 AQQllanstalEEAMLQEQ-QRLGLVWAALQGARTQLRDVR--AKKDQLEAHIQAAQAMLAMDTD 2532
Cdd:COG4717 474 LLQ--------ELEELKAElRELAEEWAALKLALELLEEAReeYREERLPPVLERASEYFSRLTD 530
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
541-582 |
1.80e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 61.17 E-value: 1.80e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 768017173 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFP 582
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1932-1976 |
2.43e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 2.43e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1932 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGcGGC 1976
Cdd:smart00180 1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP-PGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
541-589 |
2.47e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 2.47e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGC 589
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1437-1488 |
2.52e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 2.52e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 768017173 1437 CNCSGPGIqelTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDC 1488
Cdd:pfam00053 1 CDCNPHGS---LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3033-3176 |
2.87e-11 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 64.36 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3033 AMTFHGHGFLRLALSNVAPLTGNVysGFGFHSAQDSALLYYrASPDGLC---QVSLQQGRVSLQL----LRTEVKTQAGF 3105
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRTRLSI--SFSFRTTSPNGLLLY-AGSQNGGdflALELEDGRLVLRYdlgsGSLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 3106 ADGAPHYVAFYSNATGVWLYVDD--QLQQMKPHRGPPPELqpqpegPPRLLLGGLPESG------TIYNFSGCISNVFV 3176
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDGerVVESGSPGGSALLNL------DGPLYLGGLPEDLkspglpVSPGFVGCIRDLKV 150
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1486-1534 |
2.98e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 2.98e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1486 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFsldAANPKGC 1534
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1877-1930 |
3.20e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.83 E-value: 3.20e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 1877 PCDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGNCT 1930
Cdd:cd00055 1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1931-1977 |
3.67e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 3.67e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1931 RCDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG-GCR 1977
Cdd:cd00055 1 PCDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1932-1976 |
4.66e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.06 E-value: 4.66e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1932 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGC 1976
Cdd:pfam00053 1 CDCNPHGSlsDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
494-541 |
5.21e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.02 E-value: 5.21e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPC 541
Cdd:smart00180 1 CDCDPGGSASGTC--DPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1437-1481 |
6.10e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.06 E-value: 6.10e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1437 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1481
Cdd:cd00055 2 CDCNGHGSL---SGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1979-2026 |
6.50e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 59.67 E-value: 6.50e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1979 CACGP-AAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRC 2026
Cdd:pfam00053 1 CDCNPhGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1437-1481 |
1.05e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.25 E-value: 1.05e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1437 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1481
Cdd:smart00180 1 CDCDPGGSA---SGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1347-1390 |
1.50e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.86 E-value: 1.50e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 1347 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWG--FPNC 1390
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2112-2643 |
2.21e-10 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 67.00 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGgqavgtrDQASQLLAGTEATLGHAKTLLAAI 2191
Cdd:TIGR02168 295 NEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELE-------EKLEELKEELESLEAELEELEAEL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2192 RAVDRTLSELmsQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEE 2271
Cdd:TIGR02168 368 EELESRLEEL--EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2272 NQALAtQTRDRLAQHEAGLMDLREALNRA----VDATREAQELNSRnQERLEEALQRKQELSRDNATL---QATLHAARD 2344
Cdd:TIGR02168 446 EEELE-ELQEELERLEEALEELREELEEAeqalDAAERELAQLQAR-LDSLERLQENLEGFSEGVKALlknQSGLSGILG 523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2345 TLASVFR--------------------LLHSLDQAKEELERLAASLDGARTPLL---------------QRMQTFSPAGS 2389
Cdd:TIGR02168 524 VLSELISvdegyeaaieaalggrlqavVVENLNAAKKAIAFLKQNELGRVTFLPldsikgteiqgndreILKNIEGFLGV 603
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2390 KLRLVEAAEAhAQQLGQLALNLSSIILDVNQ----------------------------------------------DRL 2423
Cdd:TIGR02168 604 AKDLVKFDPK-LRKALSYLLGGVLVVDDLDNalelakklrpgyrivtldgdlvrpggvitggsaktnssilerrreiEEL 682
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2424 TQRAIEASNAYSRILQAVQAAE---DAAGQALQQADHTWATVVRQglVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQ 2500
Cdd:TIGR02168 683 EEKIEELEEKIAELEKALAELRkelEELEEELEQLRKELEELSRQ--ISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2501 GARTQLRDVRAK----KDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDT---ATRVQSQLQAMQENVERWQGQY 2573
Cdd:TIGR02168 761 AEIEELEERLEEaeeeLAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLneeAANLRERLESLERRIAATERRL 840
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017173 2574 EGLRGQ--DLGQAVLDAGHSVSTLEKTLPQLLAKLSILEN-RGVHNASLALSASigRVRELIAQARGAASKVK 2643
Cdd:TIGR02168 841 EDLEEQieELSEDIESLAAEIEELEELIEELESELEALLNeRASLEEALALLRS--ELEELSEELRELESKRS 911
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
494-543 |
3.20e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.75 E-value: 3.20e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYG-PGCQPCQC 543
Cdd:pfam00053 1 CDCNPHGSLSDTC--DPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
587-635 |
4.39e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.39e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNcQAGSCH 635
Cdd:cd00055 2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
494-543 |
4.66e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.66e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQC 543
Cdd:cd00055 2 CDCNGHGSLSGQC--DPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
2083-2523 |
9.63e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 65.06 E-value: 9.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALlpaihEQLRGiNASSmawARL--HRLNASIADLQSQLRSPLGPRHETA--QQLEVLEQQSTSLGQDARR 2158
Cdd:PRK02224 154 MIDDLLQLGKL-----EEYRE-RASD---ARLgvERVLSDQRGSLDQLKAQIEEKEEKDlhERLNGLESELAELDEEIER 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2159 LGGQ---AVGTRDQASQLLAGTEATLGHAKTLLAAIRAV---------------------DRTLSELMSQTGHL----GL 2210
Cdd:PRK02224 225 YEEQreqARETRDEADEVLEEHEERREELETLEAEIEDLretiaeterereelaeevrdlRERLEELEEERDDLlaeaGL 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2211 ANASAPSGEQLLRTL----AEVERLLWEMRArDLGAPQAAAEAELAAAQRLLAR---VQEQLSSLWEENQALATQTRDR- 2282
Cdd:PRK02224 305 DDADAEAVEARREELedrdEELRDRLEECRV-AAQAHNEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRr 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2283 --LAQHEAGLMDLREALNRAVDATREAQElnsrnqeRLEEALQRKQELSRDNATLQATLHAARDTLASVFRLL------- 2353
Cdd:PRK02224 384 eeIEELEEEIEELRERFGDAPVDLGNAED-------FLEELREERDELREREAELEATLRTARERVEEAEALLeagkcpe 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2354 ---------H--SLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSklrLVEaAEAHAQQLGQLALNLSSIILD----V 2418
Cdd:PRK02224 457 cgqpvegspHveTIEEDRERVEELEAELEDLEEEVEEVEERLERAED---LVE-AEDRIERLEERREDLEELIAErretI 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2419 NQDRLtqrAIEASNAYSRILQA-VQAAEDAAGQALQQADHTWATVV-----RQGLVDRAQQL--LANSTALEEAMLQEQQ 2490
Cdd:PRK02224 533 EEKRE---RAEELRERAAELEAeAEEKREAAAEAEEEAEEAREEVAelnskLAELKERIESLerIRTLLAAIADAEDEIE 609
|
490 500 510
....*....|....*....|....*....|....*..
gi 768017173 2491 RLGLVWAALQG----ARTQLRDVRAKKDQLEAHIQAA 2523
Cdd:PRK02224 610 RLREKREALAElndeRRERLAEKRERKRELEAEFDEA 646
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
684-736 |
1.98e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 1.98e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 684 RCSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGlDQADYFGCR 736
Cdd:cd00055 1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
587-629 |
2.79e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.01 E-value: 2.79e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHG--FPNC 629
Cdd:smart00180 1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2645-2810 |
2.99e-09 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 58.58 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2645 PMKFNGRSGVQLRTPRDLADlaaYTALKFYLQGPEPEpgqGtedrFVMYMGSrQATGDYMGVSLRDKKVHWVYQLGEaGP 2724
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRT---RLSISFSFRTTSPN---G----LLLYAGS-QNGGDFLALELEDGRLVLRYDLGS-GS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2725 AVLSIDEDIGE-QFAAVSLDRTLQFGHMSVTVERQMiqetkgDTVAPGAEGLLNLRPDdfvFYVGGYPSTFTPPPLLRFP 2803
Cdd:cd00110 69 LVLSSKTPLNDgQWHSVSVERNGRSVTLSVDGERVV------ESGSPGGSALLNLDGP---LYLGGLPEDLKSPGLPVSP 139
|
....*..
gi 768017173 2804 GYRGCIE 2810
Cdd:cd00110 140 GFVGCIR 146
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1878-1928 |
3.41e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.05 E-value: 3.41e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 1878 CDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGN 1928
Cdd:pfam00053 1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
|
|
| LamG |
smart00282 |
Laminin G domain; |
3060-3178 |
4.59e-09 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 57.35 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3060 FGFHSAQDSALLYYRASPDG---LcQVSLQQGRVSLQLLR--TEVKTQAG---FADGAPHYVAFYSNATGVWLYVDDQLQ 3131
Cdd:smart00282 4 FSFRTTSPNGLLLYAGSKGGgdyL-ALELRDGRLVLRYDLgsGPARLTSDptpLNDGQWHRVAVERNGRSVTLSVDGGNR 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 3132 QMKPHRGPPPELQPqpegPPRLLLGGLPESG------TIYNFSGCISNVFVQR 3178
Cdd:smart00282 83 VSGESPGGLTILNL----DGPLYLGGLPEDLklpplpVTPGFRGCIRNLKVNG 131
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
2112-2605 |
9.99e-09 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 61.77 E-value: 9.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHEtaQQLEVLEQQSTSLGQDARRLGGQAvgtRDQASQLL-------AGTEATLgHA 2184
Cdd:NF041483 50 AKLHEARRSLASRPAYDGADIGYQAE--QLLRNAQIQADQLRADAERELRDA---RAQTQRILqehaehqARLQAEL-HT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2185 KTLLAAIRaVDRTLSElMSQT--GHLglaNASAPSGEQL-LRTLAEVERLLWEMRARdlgaPQAAAEAELAAAQRLLARV 2261
Cdd:NF041483 124 EAVQRRQQ-LDQELAE-RRQTveSHV---NENVAWAEQLrARTESQARRLLDESRAE----AEQALAAARAEAERLAEEA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQALATQTRDRlAQHEAGLMdLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRD-NATLQATLH 2340
Cdd:NF041483 195 RQRLGSEAESARAEAEAILRR-ARKDAERL-LNAASTQAQEATDHAEQLRSSTAAESDQARRQAAELSRAaEQRMQEAEE 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2341 AARDTLASVFRLlhsLDQAKEELERLAASLDGARTpllQRMQTfspAGSKL-RLV-------EAAEAHAQQLGQLAlnls 2412
Cdd:NF041483 273 ALREARAEAEKV---VAEAKEAAAKQLASAESANE---QRTRT---AKEEIaRLVgeatkeaEALKAEAEQALADA---- 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2413 siilDVNQDRLTQRAIEASNAysrilqavQAAEDAAGQaLQQADHTwatvvrqglvdrAQQLLanSTALEEAmlQEQQRl 2492
Cdd:NF041483 340 ----RAEAEKLVAEAAEKART--------VAAEDTAAQ-LAKAART------------AEEVL--TKASEDA--KATTR- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2493 glvwAALQGARTQLRDVRAKKDQL--EAHIQAAQAMLAM--DTDETSKKIahakavaaeaqdtatrVQsqlqaMQENVER 2568
Cdd:NF041483 390 ----AAAEEAERIRREAEAEADRLrgEAADQAEQLKGAAkdDTKEYRAKT----------------VE-----LQEEARR 444
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 768017173 2569 WQGQYEGLRGQDL-------GQAVLDAGHSVSTLEKTLPQLLAK 2605
Cdd:NF041483 445 LRGEAEQLRAEAVaegerirGEARREAVQQIEEAARTAEELLTK 488
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2879-3004 |
1.04e-08 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 56.27 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2879 LRLVSYSGVLFFLK-QQSQFLCLAVQEGSLVLLYDFGAGlkkavplqpPPPLTSASKAiqvfLLGGSRKRVLVRVERATV 2957
Cdd:pfam02210 1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSG---------PESLLSSGKN----LNDGQWHSVRVERNGNTL 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2958 ySVEQDND-------------LELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIK 3004
Cdd:pfam02210 68 -TLSVDGQtvvsslppgesllLNLNGPLYLGGLPPLLLLPAL----PVRAGFVGCIRDVR 122
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
685-735 |
1.32e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.13 E-value: 1.32e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 685 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGC 735
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
685-726 |
1.96e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.70 E-value: 1.96e-08
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 768017173 685 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFG 726
Cdd:smart00180 1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
2136-2564 |
2.10e-08 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 60.61 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2136 HETAQQLEVLEQQST--------SLGQDARRLGGQAVGTRDQAsqlLAGTEATLGHA-KTLLAAIRAVDRTLSELmsqtg 2206
Cdd:NF041483 414 ADQAEQLKGAAKDDTkeyraktvELQEEARRLRGEAEQLRAEA---VAEGERIRGEArREAVQQIEEAARTAEEL----- 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2207 hlgLANASAPSGEqlLRTLA--EVERLLWEM--RARDLgapqaaaeaeLAAAQRLLARVQEQLSSLWEENQALATQTRdr 2282
Cdd:NF041483 486 ---LTKAKADADE--LRSTAtaESERVRTEAieRATTL----------RRQAEETLERTRAEAERLRAEAEEQAEEVR-- 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2283 lAQHEAGLMDLREALNRAV-----DATREAQELNSRNQERL---EEAL----QRKQELSRDNATLQATLhaaRDTLASVF 2350
Cdd:NF041483 549 -AAAERAARELREETERAIaarqaEAAEELTRLHTEAEERLtaaEEALadarAEAERIRREAAEETERL---RTEAAERI 624
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2351 RLLHSldQAKEELERL--AASLDGARTpllqRMQTFSPAgskLRLVEAAEAHAQQLGQLALNlssiildvNQDRLtqRAi 2428
Cdd:NF041483 625 RTLQA--QAEQEAERLrtEAAADASAA----RAEGENVA---VRLRSEAAAEAERLKSEAQE--------SADRV--RA- 684
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2429 EASNAYSRI-------LQAVQ--------AAEDAAGQALQQADHTwatvvRQGLVDRAQQLLANS-TALEEAMlQEQQRL 2492
Cdd:NF041483 685 EAAAAAERVgteaaeaLAAAQeeaarrrrEAEETLGSARAEADQE-----RERAREQSEELLASArKRVEEAQ-AEAQRL 758
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2493 ---------GLVWAALQGARtQLRD-VRAKKDQLEAHIQAAQAMLAMDTDETSKKiahakavaaeAQDTATRVQSQLQAM 2562
Cdd:NF041483 759 veeadrratELVSAAEQTAQ-QVRDsVAGLQEQAEEEIAGLRSAAEHAAERTRTE----------AQEEADRVRSDAYAE 827
|
..
gi 768017173 2563 QE 2564
Cdd:NF041483 828 RE 829
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1822-1875 |
2.13e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 52.74 E-value: 2.13e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 1822 CPCPLSVPSNnfaEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVLGSSC 1875
Cdd:pfam00053 1 CDCNPHGSLS---DTCDPETG--QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2256-2568 |
2.62e-08 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 60.36 E-value: 2.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLWEENQALatqtRDRLA-------------QHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAL 2322
Cdd:PRK04863 314 RELAELNEAESDLEQDYQAA----SDHLNlvqtalrqqekieRYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAE 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2323 QRKQELSRDNATLQATL----------HAARDTLASVFRLLH----SLDQAKEELERLAASLDGARTPLLQrmqtfspAG 2388
Cdd:PRK04863 390 EEVDELKSQLADYQQALdvqqtraiqyQQAVQALERAKQLCGlpdlTADNAEDWLEEFQAKEQEATEELLS-------LE 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2389 SKLRLveaAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYS--RILQAVQAAEDAAGQALQQADHTWATVVRqg 2466
Cdd:PRK04863 463 QKLSV---AQAAHSQFEQAYQLVRKIAGEVSRSEAWDVARELLRRLReqRHLAEQLQQLRMRLSELEQRLRQQQRAER-- 537
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2467 LVDRAQQLLANSTALEEAMLQEQQRLGlvwAALQGARTQLRDV-------RAKKDQLEAHIQ----------AAQAMLAM 2529
Cdd:PRK04863 538 LLAEFCKRLGKNLDDEDELEQLQEELE---ARLESLSESVSEArerrmalRQQLEQLQARIQrlaarapawlAAQDALAR 614
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 768017173 2530 ------DTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVER 2568
Cdd:PRK04863 615 lreqsgEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDE 659
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1772-1808 |
4.64e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 51.59 E-value: 4.64e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 768017173 1772 PCQCHGH---SDRCLPGSGVCVdCQHNTEGAHCERCQAGF 1808
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1773-1822 |
6.13e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.59 E-value: 6.13e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 1773 CQCHGH---SDRCLPGSGVCvDCQHNTEGAHCERCQAGFVssrDDPSAPCVSC 1822
Cdd:pfam00053 1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYY---GLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1822-1868 |
7.13e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.16 E-value: 7.13e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1822 CPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNP 1868
Cdd:smart00180 1 CDCD---PGGSASGTCDPDTG--QCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2692-2810 |
9.60e-08 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 53.19 E-value: 9.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2692 MYMGSRQatGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDI--GeQFAAVSLDRTLQFGHMSVTverqmiQETKGDTVA 2769
Cdd:pfam02210 11 LYAGGGG--SDFLALELVNGRLVLRYDLGSGPESLLSSGKNLndG-QWHSVRVERNGNTLTLSVD------GQTVVSSLP 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 768017173 2770 PGAEGLLNLrpdDFVFYVGGYPSTFTPPPLLRFPGYRGCIE 2810
Cdd:pfam02210 82 PGESLLLNL---NGPLYLGGLPPLLLLPALPVRAGFVGCIR 119
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
737-776 |
1.18e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 1.18e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 768017173 737 SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
429-473 |
1.68e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 50.04 E-value: 1.68e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 429 CNC-ESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYP 473
Cdd:pfam00053 1 CDCnPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
299-347 |
1.94e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 1.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 299 RCVCHGHADACDAKDPTDpfrLQCTCQHNTCGGTCDRCCPGFNQQPWKP 347
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGT---GQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
428-470 |
2.04e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 2.04e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 768017173 428 RCNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS 470
Cdd:cd00055 1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
429-471 |
5.21e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.85 E-value: 5.21e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 429 CNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTG--FPSC 471
Cdd:smart00180 1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
738-776 |
5.69e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.46 E-value: 5.69e-07
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 738 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1821-1876 |
7.21e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.50 E-value: 7.21e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 1821 SCPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVlGSSCQ 1876
Cdd:cd00055 1 PCDCN---GHGSLSGQCDPGTG--QCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
|
|
| TorS_sensor_domain |
cd16172 |
sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide ... |
2196-2487 |
7.29e-07 |
|
sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide (TMAO) reductase (Tor) pathway, which consists TorT, a periplasmic binding protein that binds TMAO; TorS, a sensor histidine kinase that forms a complex with TorT, and TorR, the response regulator. The Tor pathway is involved in regulating a cellular response to trimethylamine-N-oxide (TMAO), a terminal electron receptor in anaerobic respiration. TorS consists of a periplasmic sensor domain, as well as a HAMP domain, a histidine kinase domain, and a receiver domain.
Pssm-ID: 293930 [Multi-domain] Cd Length: 261 Bit Score: 53.74 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2196 RTLSELMSQTGHLG--LANAsapsgeqllRTLAEverllWEMRARDLGapqaaaeaelaaaqRLLARVQEQLSSLweENQ 2273
Cdd:cd16172 2 RQLSELSSRIIASAqlLANA---------DSEAE-----RQQQGRQLT--------------AQLEALLRLLKAL--GQD 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2274 ALATQTRDRLAQHEAGLMDLREALNRAVdatREAQELNSRNQERLEEALQRKQE---LSR---DNATLQATlhaARdtLA 2347
Cdd:cd16172 52 SFDSFLLSRLEQTVQEIIDNLAQLGELV---GQRLQLRQQFQQLFERLRAAAGElaqLARtqvANASTIAV---AN--VS 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2348 SVFRLL--HSLDQAKEELERLAA-SLDgartpLLQRMqtfspagSKLRLveaaeaHAQQLGQLALNLSSIildVNQDRLt 2424
Cdd:cd16172 124 GLYDLIeqNDKEAAYQALDRLIEvDLD-----LLERM-------HELRL------LALQLGNLINELRTA---SDIARL- 181
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2425 QRAIEASNAYSRILQA-VQAAED-----AAGQALQQADHtwatvvRQGLVDRAQQLLANSTALEEAMLQ 2487
Cdd:cd16172 182 AELRQQFNANLAILQRrVQAVEDpgrraQMAQLLSDLEQ------GQGLFALRRQLLALEQRLQALMQN 244
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
653-682 |
7.39e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.50 E-value: 7.39e-07
10 20 30
....*....|....*....|....*....|
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 682
Cdd:pfam00053 20 CLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1878-1922 |
1.46e-06 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 47.31 E-value: 1.46e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1878 CDCSGNGDpnlLFSDCDPLTGACRgCLRHTTGPRCEICAPGFYGN 1922
Cdd:smart00180 1 CDCDPGGS---ASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2112-2371 |
4.15e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 53.14 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRsplgpRHETAQQLevLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTL---- 2187
Cdd:TIGR02168 719 KELEELSRQISALRKDLA-----RLEAEVEQ--LEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELeaqi 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2188 ---LAAIRAVDRTLSELMSQTGHLGLANASAPSG-EQLLRTLAEVERLLWEM--RARDLGAPQAAAEAELAAAQRLLARV 2261
Cdd:TIGR02168 792 eqlKEELKALREALDELRAELTLLNEEAANLRERlESLERRIAATERRLEDLeeQIEELSEDIESLAAEIEELEELIEEL 871
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEE----NQALATQtRDRLAQHEAglmDLREALNRAVDATREAQELNSRN---QERLEEALQRKQEL-SRDNA 2333
Cdd:TIGR02168 872 ESELEALLNEraslEEALALL-RSELEELSE---ELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLqERLSE 947
|
250 260 270
....*....|....*....|....*....|....*...
gi 768017173 2334 TLQATLHAArdtLASVFRLLHSLDQAKEELERLAASLD 2371
Cdd:TIGR02168 948 EYSLTLEEA---EALENKIEDDEEEARRRLKRLENKIK 982
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
653-683 |
1.02e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 45.04 E-value: 1.02e-05
10 20 30
....*....|....*....|....*....|.
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGLsPSNPEGCT 683
Cdd:cd00055 21 CECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3062-3176 |
1.34e-05 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 47.03 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3062 FHSAQDSALLYYRAS--PDGLCqVSLQQGRVSLQL-----LRTEVKTQAGFADGAPHYVAF-YSNATGVwLYVDDQlqqm 3133
Cdd:pfam02210 1 FRTRQPNGLLLYAGGggSDFLA-LELVNGRLVLRYdlgsgPESLLSSGKNLNDGQWHSVRVeRNGNTLT-LSVDGQ---- 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 768017173 3134 KPHRGPPPELQPQPEGPPRLLLGGLPESGTIY------NFSGCISNVFV 3176
Cdd:pfam02210 75 TVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPalpvraGFVGCIRDVRV 123
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1773-1808 |
1.70e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 44.22 E-value: 1.70e-05
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 1773 CQCHG---HSDRCLPGSGVCvDCQHNTEGAHCERCQAGF 1808
Cdd:smart00180 1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGY 38
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
738-776 |
2.20e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 44.27 E-value: 2.20e-05
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 738 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
358-421 |
2.94e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.88 E-value: 2.94e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 358 SCNCYGHAtdcyydpevdrrrasqSLDGT-YQGGGVCIdCQHHTTGVNCERCLPGFYRSPNHPLD 421
Cdd:cd00055 1 PCDCNGHG----------------SLSGQcDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
359-426 |
5.28e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 43.11 E-value: 5.28e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 359 CNCYGHATdcyydpevdrrrasqSLDGTYQGGGVCiDCQHHTTGVNCERCLPGFYRSPNhplDSPHVC 426
Cdd:pfam00053 1 CDCNPHGS---------------LSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLPS---DPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
653-682 |
7.47e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 42.68 E-value: 7.47e-05
10 20 30
....*....|....*....|....*....|
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGlspSNPEGC 682
Cdd:smart00180 20 CECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
2026-2054 |
1.79e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 41.57 E-value: 1.79e-04
10 20 30
....*....|....*....|....*....|....
gi 768017173 2026 CQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:pfam00053 1 CDCNPhgslsDTCDPETGQCLCKPGVTGRHCDRC 34
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
2025-2054 |
2.71e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 41.19 E-value: 2.71e-04
10 20 30
....*....|....*....|....*....|....*
gi 768017173 2025 RCQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:cd00055 1 PCDCNGhgslsGQCDPGTGQCECKPNTTGRRCDRC 35
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
300-345 |
2.96e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 2.96e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 768017173 300 CVCH--GHADacdakDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPW 345
Cdd:smart00180 1 CDCDpgGSAS-----GTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
2026-2054 |
2.99e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 2.99e-04
10 20 30
....*....|....*....|....*....|....
gi 768017173 2026 CQCP-----GGRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:smart00180 1 CDCDpggsaSGTCDPDTGQCECKPNVTGRRCDRC 34
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
387-416 |
3.43e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 3.43e-04
10 20 30
....*....|....*....|....*....|
gi 768017173 387 YQGGGVCiDCQHHTTGVNCERCLPGFYRSP 416
Cdd:smart00180 14 DPDTGQC-ECKPNVTGRRCDRCAPGYYGDG 42
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
300-344 |
1.08e-03 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.26 E-value: 1.08e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 300 CVCHGHADAcdaKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQP 344
Cdd:pfam00053 1 CDCNPHGSL---SDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
|
|
| TNFRSF16 |
cd13416 |
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
1780-1946 |
8.45e-03 |
|
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.
Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 39.98 E-value: 8.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1780 DRCLPGSGVCVDC-QHNTEgahCERCQAGF----VSSRDDPSAPCVSCPCPLSVPSNnfaegCVlRGGRTQClckpgyag 1854
Cdd:cd13416 16 EQCPPGEGVARPCgDNQTV---CEPCLDGVtfsdVVSHTEPCQPCTRCPGLMSMRAP-----CT-ATHDTVC-------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1855 asceRCAPGFFGNPLvlGSSCQPCdcsgngdpnllfSDCDPLTGACRGClRHTTGPRCEICAPGFYG------NALLPgn 1928
Cdd:cd13416 79 ----ECAYGYYLDED--SGTCEPC------------TVCPPGQGVVQSC-GPNQDTVCEACPEGTYSdedsstDPCLP-- 137
|
170
....*....|....*...
gi 768017173 1929 CTRCDCTPCGTEACDPHS 1946
Cdd:cd13416 138 CTVCEDGEVELRECTPVS 155
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
45-298 |
4.21e-98 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 316.06 E-value: 4.21e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 45 LHPPYFNLAEGARIAASATCGEEAPargsprpteDLYCKLVGGPvaggdpnqtiRGQYCDICTAANSNKAHPASNAIDGT 124
Cdd:pfam00055 1 CYPAFGNLAFGREVSATSTCGLNGP---------ERYCILSGLE----------GGKKCFICDSRDPHNSHPPSNLTDSN 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 125 ER----WWQSPPLSrgLEYNEVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSMDFGRTYQPWQFFASskrDCLERFG 200
Cdd:pfam00055 62 NGtnetWWQSETGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDFGKTWQPYQYFAS---DCRRTFG 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 201 -PQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLmgkaLR 279
Cdd:pfam00055 136 rPSGPSRGIKDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDEL----LD 211
|
250
....*....|....*....
gi 768017173 280 DPTVTRRYYYSIKDISIGG 298
Cdd:pfam00055 212 DPSVLRKYYYAISDISVGG 230
|
|
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
44-298 |
4.15e-94 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 305.05 E-value: 4.15e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 44 SLHPPYFNLAEGARIAASATCGEEAPARgsprptedlYCKLVGGpvaggdpnqTIRGQYCDICTAANSNKAHPASNAIDG 123
Cdd:smart00136 6 SCYPPFVNLAFGREVTATSTCGEPGPER---------YCKLVGH---------TEQGKKCDYCDARNPRRSHPAENLTDG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 124 TE----RWWQSPPLSRGLEYneVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSmDFGRTYQPWQFFASskrDCLERF 199
Cdd:smart00136 68 NNpnnpTWWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERS-DFGKTWQPWQYFSS---DCRRTF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 200 GPQTLERITR--DDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKA 277
Cdd:smart00136 141 GRPPRGPITKgnEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDR 220
|
250 260
....*....|....*....|.
gi 768017173 278 lrdPTVTRRYYYSIKDISIGG 298
Cdd:smart00136 221 ---PEVTRRYYYAISDIAVGG 238
|
|
| Laminin_I |
pfam06008 |
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ... |
2101-2359 |
4.48e-94 |
|
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 305.88 E-value: 4.48e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2101 LRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEAT 2180
Cdd:pfam06008 1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2181 LGHAKTLLAAIRAVDRTLSELMSQTGHLGLaNASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLAR 2260
Cdd:pfam06008 81 LGHAKELAEAIKNLIDNIKEINEKVATLGE-NDFALPSSDLSRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2261 VQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLH 2340
Cdd:pfam06008 160 IQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLK 239
|
250
....*....|....*....
gi 768017173 2341 AARDTLASVFRLLHSLDQA 2359
Cdd:pfam06008 240 TARDSLDAANLLLQEIDDA 258
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
1602-1738 |
5.00e-48 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 168.99 E-value: 5.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1602 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVfvPMESRPDVVLQGNQMSITFLEPA--YPTPGHVHRGQLQLVEGNFR 1679
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPDqpPPDPGQEQTYSVRLHEENWR 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 1680 HTeTRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVE 1738
Cdd:pfam00052 79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
|
|
| LamB |
smart00281 |
Laminin B domain; |
1598-1727 |
2.04e-44 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 158.19 E-value: 2.04e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1598 FPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVpmeSRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGN 1677
Cdd:smart00281 2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1678 FRHTETRnTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASP 1727
Cdd:smart00281 79 WQYYGGR-PVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
2550-2671 |
2.38e-40 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 146.86 E-value: 2.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2550 DTATRVQSQLQAMQENVERWQGQYEGLRGQ---------DLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLa 2620
Cdd:pfam06009 10 ETAKEVLEQLAPLSQNLENTSEKLSGINRSleetnelvnDANKALDDAGRSVKKLEELAPDLLDKLKPLKQLEVNSSSL- 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 2621 lSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADLAAYTAL 2671
Cdd:pfam06009 89 -SDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3254-3411 |
4.33e-28 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 112.51 E-value: 4.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3254 SYQFGGSlsSHLEFVGiLARHRNWPSLSMHVLPRSSRGLLLFTARlRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQR 3333
Cdd:cd00110 1 GVSFSGS--SYVRLPT-LPAPRTRLSISFSFRTTSPNGLLLYAGS-QNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 3334 SRPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGaehPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLH 3411
Cdd:cd00110 77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALL---NLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3435-3585 |
9.79e-26 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.58 E-value: 9.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3435 GLFFPGSGGViTLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGefSTSVTRPSVL 3514
Cdd:cd00110 1 GVSFSGSSYV-RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 3515 CDGQWHRLAVMKSGNVLRLEVD-AQSNHTVGPLLAAAAGAPAPLYLGGLPEPMAV--QPWPPAYCGCMRRLAVN 3585
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDgERVVESGSPGGSALLNLDGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
3279-3413 |
1.74e-25 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 104.34 E-value: 1.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3279 SLSMHVLPRSSRGLLLFTARlRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRS-RPGRWHKVSVRWEKNRILLVTDG 3357
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGS-KGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPlNDGQWHRVAVERNGRSVTLSVDG 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 3358 ARAWSQEGPhRQHQGAEHPQPhtLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGR 3413
Cdd:smart00282 80 GNRVSGESP-GGLTILNLDGP--LYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3286-3413 |
1.62e-22 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 95.56 E-value: 1.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3286 PRSSRGLLLFTARLRpgSPSLALFLSNGHFVAQME-GLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQE 3364
Cdd:pfam02210 3 TRQPNGLLLYAGGGG--SDFLALELVNGRLVLRYDlGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 768017173 3365 GPHRQHQgaeHPQPHTLFVGGLPASSHSSKLPVTVGFSGCVKRLRLHGR 3413
Cdd:pfam02210 81 PPGESLL---LNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
|
|
| LamG |
smart00282 |
Laminin G domain; |
3459-3586 |
1.62e-21 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 92.79 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3459 LELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVlCDGQWHRLAVMKSGNVLRLEVDAQ 3538
Cdd:smart00282 2 ISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL-NDGQWHRVAVERNGRSVTLSVDGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 3539 SN-HTVGPLLAAAAGAPAPLYLGGLPEPM--AVQPWPPAYCGCMRRLAVNR 3586
Cdd:smart00282 81 NRvSGESPGGLTILNLDGPLYLGGLPEDLklPPLPVTPGFRGCIRNLKVNG 131
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3463-3585 |
8.85e-20 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 87.86 E-value: 8.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3463 VRPLAVTGLIFHLGQARTPpYLQLQVTEKQVLLRADDGAGEFSTSVTrPSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHT 3542
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 768017173 3543 VGPLLAAAAGAPAPL-YLGGLPEP--MAVQPWPPAYCGCMRRLAVN 3585
Cdd:pfam02210 79 SLPPGESLLLNLNGPlYLGGLPPLllLPALPVRAGFVGCIRDVRVN 124
|
|
| LamG |
smart00282 |
Laminin G domain; |
2690-2817 |
1.67e-15 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 75.84 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2690 FVMYMGSRQaTGDYMGVSLRDKKVHWVYQLGeAGPAVLSIDEDI---GeQFAAVSLDRTLQFGHMSVTVERQMIQETkgd 2766
Cdd:smart00282 14 LLLYAGSKG-GGDYLALELRDGRLVLRYDLG-SGPARLTSDPTPlndG-QWHRVAVERNGRSVTLSVDGGNRVSGES--- 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 2767 tvaPGAEGLLNLrpdDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEE 2817
Cdd:smart00282 88 ---PGGLTILNL---DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2256-2528 |
9.35e-15 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 81.52 E-value: 9.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATL 2335
Cdd:COG1196 249 EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2336 QATLHAARDTLAsvfRLLHSLDQAKEELERLAASLDGARTPLLQRmqtfspAGSKLRLVEAAEAHAQQLGQLALNLSSII 2415
Cdd:COG1196 329 EEELEELEEELE---ELEEELEEAEEELEEAEAELAEAEEALLEA------EAELAEAEEELEELAEELLEALRAAAELA 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2416 LDVNQDRLTQRAIEASNAysRILQAVQAAEDAAGQALQQADHTwatvvrQGLVDRAQQLLANSTALEEAMLQEQQRLGlv 2495
Cdd:COG1196 400 AQLEELEEAEEALLERLE--RLEEELEELEEALAELEEEEEEE------EEALEEAAEEEAELEEEEEALLELLAELL-- 469
|
250 260 270
....*....|....*....|....*....|...
gi 768017173 2496 wAALQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG1196 470 -EEAALLEAALAELLEELAEAAARLLLLLEAEA 501
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2852-3004 |
2.99e-14 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 72.84 E-value: 2.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2852 GSYLDGTGFARISFDSQISTTKRFEQELRLVSYSGVLFFL--KQQSQFLCLAVQEGSLVLLYDFGAGlkkAVPLQPPPPL 2929
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSG---SLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2930 -TSASKAIQVFLLGgsrKRVLVRVER---ATVYSVEQDNDLELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIK 3004
Cdd:cd00110 78 nDGQWHSVSVERNG---RSVTLSVDGervVESGSPGGSALLNLDGPLYLGGLPEDLKSPGL----PVSPGFVGCIRDLK 149
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
2115-2604 |
7.86e-14 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 78.29 E-value: 7.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2115 HRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAV 2194
Cdd:pfam01576 183 NKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNA 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2195 DRTLSELMSQTGHL--GLANasapsgEQLLRTLAEVERllwemraRDLGAPQAAAEAELAAAQRLLArVQEQLSSLWEE- 2271
Cdd:pfam01576 263 LKKIRELEAQISELqeDLES------ERAARNKAEKQR-------RDLGEELEALKTELEDTLDTTA-AQQELRSKREQe 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2272 ----NQALATQTRdrlaQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAlqrKQELSRDNATLQATlhaardtla 2347
Cdd:pfam01576 329 vtelKKALEEETR----SHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKA---KQALESENAELQAE--------- 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2348 svfrlLHSLDQAKEELERLAASLDGArtplLQRMQTFSPAGSKLRlVEAAEahaqQLGQLALNLSSI--ILDVNQDRLTQ 2425
Cdd:pfam01576 393 -----LRTLQQAKQDSEHKRKKLEGQ----LQELQARLSESERQR-AELAE----KLSKLQSELESVssLLNEAEGKNIK 458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2426 RAIEASNAYSRiLQAVQaaedaagQALQQadhtwatvvrqglvdRAQQLLANSTALEEAmlqEQQRLGLvwaalqgaRTQ 2505
Cdd:pfam01576 459 LSKDVSSLESQ-LQDTQ-------ELLQE---------------ETRQKLNLSTRLRQL---EDERNSL--------QEQ 504
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2506 LRDVRAKKDQLEAHIQAAQAMLAmdtdETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRG------Q 2579
Cdd:pfam01576 505 LEEEEEAKRNVERQLSTLQAQLS----DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKtknrlqQ 580
|
490 500 510
....*....|....*....|....*....|.
gi 768017173 2580 DLGQAVLDAGHS---VSTLEK---TLPQLLA 2604
Cdd:pfam01576 581 ELDDLLVDLDHQrqlVSNLEKkqkKFDQMLA 611
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1347-1395 |
1.61e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 67.38 E-value: 1.61e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1347 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDC 1395
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2082-2645 |
1.79e-13 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 76.73 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2082 LLLDDLERAGALLPAIHEQLRGINAssmawARLHRLNASIADLQSQ---LRSPLGPRHETAQQLEVLEQQSTSLGQDARR 2158
Cdd:COG4717 46 MLLERLEKEADELFKPQGRKPELNL-----KELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2159 LggqavgtrDQASQLLAgteatlghaktLLAAIRAVDRTLSELMSQTghlglanasapsgEQLLRTLAEVERLLWEMRAR 2238
Cdd:COG4717 121 L--------EKLLQLLP-----------LYQELEALEAELAELPERL-------------EELEERLEELRELEEELEEL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2239 DlgapqaaaeaelaaaqRLLARVQEQLSSLWEEnqaLATQTRDRLAqheaglmDLREALNRAVDATREAQELNSRNQERL 2318
Cdd:COG4717 169 E----------------AELAELQEELEELLEQ---LSLATEEELQ-------DLAEELEELQQRLAELEEELEEAQEEL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2319 EEALQRKQELSRD--NATLQATLHAARdTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEA 2396
Cdd:COG4717 223 EELEEELEQLENEleAAALEERLKEAR-LLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2397 AEAHAQQLGQLALNLSSIILdvnQDRLTQRAIEASNAYSRILQAVQAAEDAAgQALQQADHTWATVVRQGLVDRAQQLLA 2476
Cdd:COG4717 302 KEAEELQALPALEELEEEEL---EELLAALGLPPDLSPEELLELLDRIEELQ-ELLREAEELEEELQLEELEQEIAALLA 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2477 NSTALEEAMLQEqqrlglvWAALQGARTQLR-DVRAKKDQLEAHIQAAQAMLAMDTDETskkiahakavaaeAQDTATRV 2555
Cdd:COG4717 378 EAGVEDEEELRA-------ALEQAEEYQELKeELEELEEQLEELLGELEELLEALDEEE-------------LEEELEEL 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2556 QSQLQAMQENVERWQGQYEGLRGQdlgQAVLDAGHSVSTLEKTLPQLLAKLSILENRgvhNASLALsasigrVRELIAQA 2635
Cdd:COG4717 438 EEELEELEEELEELREELAELEAE---LEQLEEDGELAELLQELEELKAELRELAEE---WAALKL------ALELLEEA 505
|
570
....*....|
gi 768017173 2636 RGAASKVKVP 2645
Cdd:COG4717 506 REEYREERLP 515
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1486-1534 |
2.68e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.61 E-value: 2.68e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1486 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1534
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| LamG |
smart00282 |
Laminin G domain; |
2874-3008 |
4.46e-13 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 68.91 E-value: 4.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2874 RFEQELRLVSYSGVLFFL--KQQSQFLCLAVQEGSLVLLYDFGAGLKKAVPlQPPPPLTSASKAIQVFLLGgsrKRVLVR 2951
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNG---RSVTLS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2952 V---ERATVYSVEQDNDLELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIKALGK 3008
Cdd:smart00282 77 VdggNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPL----PVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
3463-3589 |
9.38e-13 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 67.73 E-value: 9.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3463 VRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEfsTSVTRPSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHT 3542
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 3543 VGPLLAAAAG--APAPLYLGGLPEpMAVQPWP----PAYCGCMRRLAVNRSPV 3589
Cdd:pfam00054 79 GESPLGATTDldVDGPLYVGGLPS-LGVKKRRlaisPSFDGCIRDVIVNGKPL 130
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2112-2636 |
2.37e-12 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 73.43 E-value: 2.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRsPLGPRHETAQ-------QLEVLEQQSTSL-----GQDARRLGGQAVGTRDQASQL---LAG 2176
Cdd:COG1196 186 ENLERLEDILGELERQLE-PLERQAEKAEryrelkeELKELEAELLLLklrelEAELEELEAELEELEAELEELeaeLAE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2177 TEATLGHAKTLLAAIR-AVDRTLSELMSQTGHLG-LANASAPSGEQLLRTLAEVERLLWEMRArdlgapqaaaeaelaaa 2254
Cdd:COG1196 265 LEAELEELRLELEELElELEEAQAEEYELLAELArLEQDIARLEERRRELEERLEELEEELAE----------------- 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2255 qrLLARVQEQLSSLwEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNAT 2334
Cdd:COG1196 328 --LEEELEELEEEL-EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEE 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2335 LQATLHAARDTLAsvfRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFspAGSKLRLVEAAEAHAQQLGQLALNLSSI 2414
Cdd:COG1196 405 LEEAEEALLERLE---RLEEELEELEEALAELEEEEEEEEEALEEAAEEE--AELEEEEEALLELLAELLEEAALLEAAL 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2415 I-LDVNQDRLTQRA---IEASNAYSRILQAVQAAEDAAGQALQQADH----TWATVVRQGLVDRAQQLLAN------STA 2480
Cdd:COG1196 480 AeLLEELAEAAARLlllLEAEADYEGFLEGVKAALLLAGLRGLAGAVavliGVEAAYEAALEAALAAALQNivveddEVA 559
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2481 LEEAMLQEQQRLGLVwAALQGARTQLRDVRAKKDQLEAhIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQ 2560
Cdd:COG1196 560 AAAIEYLKAAKAGRA-TFLPLDKIRARAALAAALARGA-IGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALR 637
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 2561 AMQENVERWQGqyEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQAR 2636
Cdd:COG1196 638 RAVTLAGRLRE--VTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
540-583 |
2.38e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 63.91 E-value: 2.38e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 768017173 540 PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL 583
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
587-634 |
5.76e-12 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 62.76 E-value: 5.76e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQAGSC 634
Cdd:pfam00053 1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1978-2024 |
6.38e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 6.38e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1978 PCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQ--GCR 2024
Cdd:cd00055 1 PCDCnGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQggGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1485-1535 |
6.70e-12 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 62.76 E-value: 6.70e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 1485 PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSlDAANPKGCT 1535
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1979-2023 |
1.25e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 61.94 E-value: 1.25e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 1979 CACGPA-AEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGC 2023
Cdd:smart00180 1 CDCDPGgSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1346-1388 |
1.30e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 61.99 E-value: 1.30e-11
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 768017173 1346 PCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1388
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2084-2532 |
1.43e-11 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 70.57 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2084 LDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQ---LRSPLGPRHETAQQLEVLEQQSTSLGQDARRLG 2160
Cdd:COG4717 104 LEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERleeLEERLEELRELEEELEELEAELAELQEELEELL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2161 GQ-AVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRT----LAEVERLLWEM 2235
Cdd:COG4717 184 EQlSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllLIAAALLALLG 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2236 RARDLGAPQAAAEAELAAAQRLLA-----RVQEQLSSLWEENQALATQTRDRLAQHEagLMDLREALNRAVDATREAQEL 2310
Cdd:COG4717 264 LGGSLLSLILTIAGVLFLVLGLLAllfllLAREKASLGKEAEELQALPALEELEEEE--LEELLAALGLPPDLSPEELLE 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2311 NSRNQERLEEALQRKQELSRdnatlQATLHAARDTLASVFRLLHSLDqaKEELERLAAsldgartpLLQRMQtfspagsk 2390
Cdd:COG4717 342 LLDRIEELQELLREAEELEE-----ELQLEELEQEIAALLAEAGVED--EEELRAALE--------QAEEYQ-------- 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2391 lRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAysriLQAVQAAEDAAGQALQQADHTWATVVRQGLVDR 2470
Cdd:COG4717 399 -ELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEE----LEELEEELEELREELAELEAELEQLEEDGELAE 473
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 2471 AQQllanstalEEAMLQEQ-QRLGLVWAALQGARTQLRDVR--AKKDQLEAHIQAAQAMLAMDTD 2532
Cdd:COG4717 474 LLQ--------ELEELKAElRELAEEWAALKLALELLEEAReeYREERLPPVLERASEYFSRLTD 530
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
541-582 |
1.80e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 61.17 E-value: 1.80e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 768017173 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFP 582
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1932-1976 |
2.43e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 2.43e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1932 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGcGGC 1976
Cdd:smart00180 1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP-PGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
541-589 |
2.47e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 2.47e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGC 589
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1437-1488 |
2.52e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.83 E-value: 2.52e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 768017173 1437 CNCSGPGIqelTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDC 1488
Cdd:pfam00053 1 CDCNPHGS---LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
3033-3176 |
2.87e-11 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 64.36 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3033 AMTFHGHGFLRLALSNVAPLTGNVysGFGFHSAQDSALLYYrASPDGLC---QVSLQQGRVSLQL----LRTEVKTQAGF 3105
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRTRLSI--SFSFRTTSPNGLLLY-AGSQNGGdflALELEDGRLVLRYdlgsGSLVLSSKTPL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 3106 ADGAPHYVAFYSNATGVWLYVDD--QLQQMKPHRGPPPELqpqpegPPRLLLGGLPESG------TIYNFSGCISNVFV 3176
Cdd:cd00110 78 NDGQWHSVSVERNGRSVTLSVDGerVVESGSPGGSALLNL------DGPLYLGGLPEDLkspglpVSPGFVGCIRDLKV 150
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1486-1534 |
2.98e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.79 E-value: 2.98e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1486 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFsldAANPKGC 1534
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1877-1930 |
3.20e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.83 E-value: 3.20e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 1877 PCDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGNCT 1930
Cdd:cd00055 1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2294-2635 |
3.44e-11 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 69.98 E-value: 3.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2294 REALNRAVDATRE---AQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASV---FRLLHSLDQAKEELERLA 2367
Cdd:COG3096 281 RELSERALELRRElfgARRQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLNLVqtaLRQQEKIERYQEDLEELT 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2368 ASLdgartpllqRMQTFSPAGSKLRLVEA-AEAHAQQL------GQLAlnlssiilDVNQ--DRLTQRAIeasnAYSril 2438
Cdd:COG3096 361 ERL---------EEQEEVVEEAAEQLAEAeARLEAAEEevdslkSQLA--------DYQQalDVQQTRAI----QYQ--- 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2439 QAVQAAEDAAGQaLQQADHTWAtvvrqGLVDRAQQLLANSTALEEAMLQEQQRLGLVWA--------------------- 2497
Cdd:COG3096 417 QAVQALEKARAL-CGLPDLTPE-----NAEDYLAAFRAKEQQATEEVLELEQKLSVADAarrqfekayelvckiagever 490
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2498 --ALQGARTQLRDVRakkdQLEAHIQAAQAmLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAmQENVERWQGQYEG 2575
Cdd:COG3096 491 sqAWQTARELLRRYR----SQQALAQRLQQ-LRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDA-AEELEELLAELEA 564
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2576 LRgQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGvhNASLALSASIGRVRELIAQA 2635
Cdd:COG3096 565 QL-EELEEQAAEAVEQRSELRQQLEQLRARIKELAARA--PAWLAAQDALERLREQSGEA 621
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1931-1977 |
3.67e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 3.67e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 1931 RCDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG-GCR 1977
Cdd:cd00055 1 PCDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1932-1976 |
4.66e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 60.06 E-value: 4.66e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1932 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGC 1976
Cdd:pfam00053 1 CDCNPHGSlsDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
494-541 |
5.21e-11 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 60.02 E-value: 5.21e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPC 541
Cdd:smart00180 1 CDCDPGGSASGTC--DPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1437-1481 |
6.10e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.06 E-value: 6.10e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1437 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1481
Cdd:cd00055 2 CDCNGHGSL---SGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1979-2026 |
6.50e-11 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 59.67 E-value: 6.50e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 1979 CACGP-AAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRC 2026
Cdd:pfam00053 1 CDCNPhGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1437-1481 |
1.05e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 59.25 E-value: 1.05e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1437 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1481
Cdd:smart00180 1 CDCDPGGSA---SGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2083-2456 |
1.32e-10 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 68.06 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALLPAIHEQLrginasSMAWARLHRLNASIADLQSQLrsplgprhetAQQLEVLEQQSTSLGQDArrlggQ 2162
Cdd:COG3096 359 LTERLEEQEEVVEEAAEQL------AEAEARLEAAEEEVDSLKSQL----------ADYQQALDVQQTRAIQYQ-----Q 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2163 AVGTRDQASQLLAGTEATLGHAKTLLAAIRA-VDRTLSELMSQTGHLGLANASAPSGE---QLLRTLA-EVERL-LWEmR 2236
Cdd:COG3096 418 AVQALEKARALCGLPDLTPENAEDYLAAFRAkEQQATEEVLELEQKLSVADAARRQFEkayELVCKIAgEVERSqAWQ-T 496
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2237 ARDLgapqaaaeaelaaaqrlLARvqeqlsslWEENQALAtqtrDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQE 2316
Cdd:COG3096 497 AREL-----------------LRR--------YRSQQALA----QRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQ 547
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2317 RLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASldgartpllqrmqtfSPAGSKLRlvEA 2396
Cdd:COG3096 548 QLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAAR---------------APAWLAAQ--DA 610
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2397 AEAHAQQLGQlALNLSSIILDVNQdRLTQRAIEASNAYSRILQAVQAAEDAAGQaLQQAD 2456
Cdd:COG3096 611 LERLREQSGE-ALADSQEVTAAMQ-QLLEREREATVERDELAARKQALESQIER-LSQPG 667
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1347-1390 |
1.50e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.86 E-value: 1.50e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 1347 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWG--FPNC 1390
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2112-2643 |
2.21e-10 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 67.00 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGgqavgtrDQASQLLAGTEATLGHAKTLLAAI 2191
Cdd:TIGR02168 295 NEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELE-------EKLEELKEELESLEAELEELEAEL 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2192 RAVDRTLSELmsQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEE 2271
Cdd:TIGR02168 368 EELESRLEEL--EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2272 NQALAtQTRDRLAQHEAGLMDLREALNRA----VDATREAQELNSRnQERLEEALQRKQELSRDNATL---QATLHAARD 2344
Cdd:TIGR02168 446 EEELE-ELQEELERLEEALEELREELEEAeqalDAAERELAQLQAR-LDSLERLQENLEGFSEGVKALlknQSGLSGILG 523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2345 TLASVFR--------------------LLHSLDQAKEELERLAASLDGARTPLL---------------QRMQTFSPAGS 2389
Cdd:TIGR02168 524 VLSELISvdegyeaaieaalggrlqavVVENLNAAKKAIAFLKQNELGRVTFLPldsikgteiqgndreILKNIEGFLGV 603
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2390 KLRLVEAAEAhAQQLGQLALNLSSIILDVNQ----------------------------------------------DRL 2423
Cdd:TIGR02168 604 AKDLVKFDPK-LRKALSYLLGGVLVVDDLDNalelakklrpgyrivtldgdlvrpggvitggsaktnssilerrreiEEL 682
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2424 TQRAIEASNAYSRILQAVQAAE---DAAGQALQQADHTWATVVRQglVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQ 2500
Cdd:TIGR02168 683 EEKIEELEEKIAELEKALAELRkelEELEEELEQLRKELEELSRQ--ISALRKDLARLEAEVEQLEERIAQLSKELTELE 760
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2501 GARTQLRDVRAK----KDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDT---ATRVQSQLQAMQENVERWQGQY 2573
Cdd:TIGR02168 761 AEIEELEERLEEaeeeLAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLneeAANLRERLESLERRIAATERRL 840
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017173 2574 EGLRGQ--DLGQAVLDAGHSVSTLEKTLPQLLAKLSILEN-RGVHNASLALSASigRVRELIAQARGAASKVK 2643
Cdd:TIGR02168 841 EDLEEQieELSEDIESLAAEIEELEELIEELESELEALLNeRASLEEALALLRS--ELEELSEELRELESKRS 911
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
3287-3416 |
2.38e-10 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 60.79 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3287 RSSRGLLLFTARlRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQEGP 3366
Cdd:pfam00054 4 TEPSGLLLYNGT-QTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGESP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 768017173 3367 HRQHQgaeHPQ-PHTLFVGGLP-ASSHSSKLPVTVGFSGCVKRLRLHGRPLG 3416
Cdd:pfam00054 83 LGATT---DLDvDGPLYVGGLPsLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
494-543 |
3.20e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.75 E-value: 3.20e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYG-PGCQPCQC 543
Cdd:pfam00053 1 CDCNPHGSLSDTC--DPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
587-635 |
4.39e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.39e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNcQAGSCH 635
Cdd:cd00055 2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
494-543 |
4.66e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.66e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 768017173 494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQC 543
Cdd:cd00055 2 CDCNGHGSLSGQC--DPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2083-2562 |
5.47e-10 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 65.73 E-value: 5.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALLPAIHEQLRGINAssmawaRLHRLNASIADLQSQLRsplgprhETAQQLEVLEQQSTSLGQDARRLGGQ 2162
Cdd:COG1196 314 LEERLEELEEELAELEEELEELEE------ELEELEEELEEAEEELE-------EAEAELAEAEEALLEAEAELAEAEEE 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2163 AVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASApSGEQLLRTLAEVERLLWEMRARDLga 2242
Cdd:COG1196 381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL-EEEEEEEEEALEEAAEEEAELEEE-- 457
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2243 pqaaaeaelaaAQRLLARVQEQLSS--LWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELnsRNQERLEE 2320
Cdd:COG1196 458 -----------EEALLELLAELLEEaaLLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL--AGLRGLAG 524
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2321 ALQrkqELSRDNATLQATLhAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPL-LQRMQTFSPAGSKLRLVEAAEA 2399
Cdd:COG1196 525 AVA---VLIGVEAAYEAAL-EAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpLDKIRARAALAAALARGAIGAA 600
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2400 HAqqLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQG------------- 2466
Cdd:COG1196 601 VD--LVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGsrrellaalleae 678
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2467 -----LVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHA 2541
Cdd:COG1196 679 aeleeLAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPE 758
|
490 500
....*....|....*....|.
gi 768017173 2542 KAVAAEAQDTATRVQSQLQAM 2562
Cdd:COG1196 759 PPDLEELERELERLEREIEAL 779
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2270-2577 |
6.45e-10 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 65.46 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2270 EENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLAsv 2349
Cdd:TIGR02168 221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIS-- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2350 fRLLHSLDQAKEELERLAASLDGARTPLLQRMQtfspagSKLRLVEAAEAHAQQLGQLALNLSSIildvnQDRLTQRAIE 2429
Cdd:TIGR02168 299 -RLEQQKQILRERLANLERQLEELEAQLEELES------KLDELAEELAELEEKLEELKEELESL-----EAELEELEAE 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2430 ASNAYSRILQAVQAAEDAAG---QALQQADHTWATVVR-----QGLVDRAQQLLAN----STALEEAMLQE-QQRLGLVW 2496
Cdd:TIGR02168 367 LEELESRLEELEEQLETLRSkvaQLELQIASLNNEIERlearlERLEDRRERLQQEieelLKKLEEAELKElQAELEELE 446
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2497 AALQGARTQLRDVRAKKDQLEAHIQAAQAMLamdtdetskkiahakavaAEAQDTATRVQSQLQAMQENVERWQGQYEGL 2576
Cdd:TIGR02168 447 EELEELQEELERLEEALEELREELEEAEQAL------------------DAAERELAQLQARLDSLERLQENLEGFSEGV 508
|
.
gi 768017173 2577 R 2577
Cdd:TIGR02168 509 K 509
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2085-2639 |
9.09e-10 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 64.94 E-value: 9.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2085 DDLERAGALLPAIHEQ---LRGINAssmAWARLHRLNASIADLQsQLRSPLgpRHETAQQ-LEVLEQQSTSLGQDARRLG 2160
Cdd:COG4913 235 DDLERAHEALEDAREQielLEPIRE---LAERYAAARERLAELE-YLRAAL--RLWFAQRrLELLEAELEELRAELARLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2161 GQAVGTRDQASQLLAgteatlgHAKTLLAAIRAVDrtlselmsqtghlglanasapsGEQLLRTLAEVERLLWEMRARdl 2240
Cdd:COG4913 309 AELERLEARLDALRE-------ELDELEAQIRGNG----------------------GDRLEQLEREIERLERELEER-- 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2241 gapqaaaeaelaaaQRLLARVQEQLSSL----------WEENQALATQTRDRLAQHEAglmDLREALNRAVDATREAQEl 2310
Cdd:COG4913 358 --------------ERRRARLEALLAALglplpasaeeFAALRAEAAALLEALEEELE---ALEEALAEAEAALRDLRR- 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2311 nsrnqeRLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHS--------LDQAKEELE-RLAAS--LDGARTPLLQ 2379
Cdd:COG4913 420 ------ELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAelpfvgelIEVRPEEERwRGAIErvLGGFALTLLV 493
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2380 RMQTFSPAGS-------KLRLV-EAAEAHAQQLGQLALNLSSIIldvnqDRLTQRAIEASNAYSRILQ---AVQAAEDAa 2448
Cdd:COG4913 494 PPEHYAAALRwvnrlhlRGRLVyERVRTGLPDPERPRLDPDSLA-----GKLDFKPHPFRAWLEAELGrrfDYVCVDSP- 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2449 gQALQQadHTWAtVVRQGLV---------------DRAQQLLANSTALEEAMLQEQQRLGlvwAALQGARTQLRDVRAKK 2513
Cdd:COG4913 568 -EELRR--HPRA-ITRAGQVkgngtrhekddrrriRSRYVLGFDNRAKLAALEAELAELE---EELAEAEERLEALEAEL 640
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2514 DQLEAHIQAAQAMLAM-----DTDETSKKIahakavaAEAQDTATRV---QSQLQAMQENVERWQGQYEGLRGQ--DLGQ 2583
Cdd:COG4913 641 DALQERREALQRLAEYswdeiDVASAEREI-------AELEAELERLdasSDDLAALEEQLEELEAELEELEEEldELKG 713
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 2584 AVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSAsigRVRELIAQARGAA 2639
Cdd:COG4913 714 EIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEE---RFAAALGDAVERE 766
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
2083-2523 |
9.63e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 65.06 E-value: 9.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALlpaihEQLRGiNASSmawARL--HRLNASIADLQSQLRSPLGPRHETA--QQLEVLEQQSTSLGQDARR 2158
Cdd:PRK02224 154 MIDDLLQLGKL-----EEYRE-RASD---ARLgvERVLSDQRGSLDQLKAQIEEKEEKDlhERLNGLESELAELDEEIER 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2159 LGGQ---AVGTRDQASQLLAGTEATLGHAKTLLAAIRAV---------------------DRTLSELMSQTGHL----GL 2210
Cdd:PRK02224 225 YEEQreqARETRDEADEVLEEHEERREELETLEAEIEDLretiaeterereelaeevrdlRERLEELEEERDDLlaeaGL 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2211 ANASAPSGEQLLRTL----AEVERLLWEMRArDLGAPQAAAEAELAAAQRLLAR---VQEQLSSLWEENQALATQTRDR- 2282
Cdd:PRK02224 305 DDADAEAVEARREELedrdEELRDRLEECRV-AAQAHNEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRr 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2283 --LAQHEAGLMDLREALNRAVDATREAQElnsrnqeRLEEALQRKQELSRDNATLQATLHAARDTLASVFRLL------- 2353
Cdd:PRK02224 384 eeIEELEEEIEELRERFGDAPVDLGNAED-------FLEELREERDELREREAELEATLRTARERVEEAEALLeagkcpe 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2354 ---------H--SLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSklrLVEaAEAHAQQLGQLALNLSSIILD----V 2418
Cdd:PRK02224 457 cgqpvegspHveTIEEDRERVEELEAELEDLEEEVEEVEERLERAED---LVE-AEDRIERLEERREDLEELIAErretI 532
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2419 NQDRLtqrAIEASNAYSRILQA-VQAAEDAAGQALQQADHTWATVV-----RQGLVDRAQQL--LANSTALEEAMLQEQQ 2490
Cdd:PRK02224 533 EEKRE---RAEELRERAAELEAeAEEKREAAAEAEEEAEEAREEVAelnskLAELKERIESLerIRTLLAAIADAEDEIE 609
|
490 500 510
....*....|....*....|....*....|....*..
gi 768017173 2491 RLGLVWAALQG----ARTQLRDVRAKKDQLEAHIQAA 2523
Cdd:PRK02224 610 RLREKREALAElndeRRERLAEKRERKRELEAEFDEA 646
|
|
| COG3903 |
COG3903 |
Predicted ATPase [General function prediction only]; |
2082-2510 |
1.64e-09 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443109 [Multi-domain] Cd Length: 933 Bit Score: 64.27 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2082 LLLDDLERAGALLPAIHEQLRginaSSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGG 2161
Cdd:COG3903 509 LRGPDQLAWLARLDAEHDNLR----AALRWALAHGDAELALRLAAALAPFWFLRGLLREGRRWLERALAAAGEAAAALAA 584
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2162 QAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLG 2241
Cdd:COG3903 585 AAALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 664
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2242 APQAAAEAELAAAQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEA 2321
Cdd:COG3903 665 ALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAA 744
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2322 LQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHA 2401
Cdd:COG3903 745 LALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAA 824
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2402 QQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTAL 2481
Cdd:COG3903 825 AAAAALAAALAAAAAAAAAAAAAAAAAAALAAALAAAAAAAAAAALAAAAAAAAAAAAALLAAAAAAAAAAAAAAAAAAA 904
|
410 420
....*....|....*....|....*....
gi 768017173 2482 EEAMLQEQQRLGLVWAALQGARTQLRDVR 2510
Cdd:COG3903 905 LAAAAAAAAAAALAAAAAAAAAAAAAAAA 933
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
684-736 |
1.98e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 1.98e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 684 RCSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGlDQADYFGCR 736
Cdd:cd00055 1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
2124-2533 |
2.06e-09 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 63.38 E-value: 2.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2124 LQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRlggqavgTRDQASQLLAGTEATLGHAKTLLAAIRavdRTLSELMS 2203
Cdd:pfam07888 32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKR-------DREQWERQRRELESRVAELKEELRQSR---EKHEELEE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2204 QtgHLGLANASApsgeqllrTLAEVERLLWEMRARDlgapqaaaeaelaaaqrlLARVQEqlssLWEENQALATQTRDRl 2283
Cdd:pfam07888 102 K--YKELSASSE--------ELSEEKDALLAQRAAH------------------EARIRE----LEEDIKTLTQRVLER- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2284 aqhEAGLMDLREALNRAVDATREAQELNSRNQERLEealQRKQELSRDNATLQA--TLHAARDTLA-----SVFRLLHSL 2356
Cdd:pfam07888 149 ---ETELERMKERAKKAGAQRKEEEAERKQLQAKLQ---QTEEELRSLSKEFQElrNSLAQRDTQVlqlqdTITTLTQKL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2357 DQAKE---ELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQ--------QLGQLALNLSSIILDVNQDRLT- 2424
Cdd:pfam07888 223 TTAHRkeaENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQaelhqarlQAAQLTLQLADASLALREGRARw 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2425 -------QRAIEASNaySRIL---QAVQAAEdaagQALQQadhtwATVVRQGL-VDRAQQLLANSTALEEAM--LQEQQr 2491
Cdd:pfam07888 303 aqeretlQQSAEADK--DRIEklsAELQRLE----ERLQE-----ERMEREKLeVELGREKDCNRVQLSESRreLQELK- 370
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 768017173 2492 lglvwAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDE 2533
Cdd:pfam07888 371 -----ASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVADA 407
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
587-629 |
2.79e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 55.01 E-value: 2.79e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHG--FPNC 629
Cdd:smart00180 1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2645-2810 |
2.99e-09 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 58.58 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2645 PMKFNGRSGVQLRTPRDLADlaaYTALKFYLQGPEPEpgqGtedrFVMYMGSrQATGDYMGVSLRDKKVHWVYQLGEaGP 2724
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAPRT---RLSISFSFRTTSPN---G----LLLYAGS-QNGGDFLALELEDGRLVLRYDLGS-GS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2725 AVLSIDEDIGE-QFAAVSLDRTLQFGHMSVTVERQMiqetkgDTVAPGAEGLLNLRPDdfvFYVGGYPSTFTPPPLLRFP 2803
Cdd:cd00110 69 LVLSSKTPLNDgQWHSVSVERNGRSVTLSVDGERVV------ESGSPGGSALLNLDGP---LYLGGLPEDLKSPGLPVSP 139
|
....*..
gi 768017173 2804 GYRGCIE 2810
Cdd:cd00110 140 GFVGCIR 146
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1878-1928 |
3.41e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.05 E-value: 3.41e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 1878 CDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGN 1928
Cdd:pfam00053 1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
|
|
| LamG |
smart00282 |
Laminin G domain; |
3060-3178 |
4.59e-09 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 57.35 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3060 FGFHSAQDSALLYYRASPDG---LcQVSLQQGRVSLQLLR--TEVKTQAG---FADGAPHYVAFYSNATGVWLYVDDQLQ 3131
Cdd:smart00282 4 FSFRTTSPNGLLLYAGSKGGgdyL-ALELRDGRLVLRYDLgsGPARLTSDptpLNDGQWHRVAVERNGRSVTLSVDGGNR 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 3132 QMKPHRGPPPELQPqpegPPRLLLGGLPESG------TIYNFSGCISNVFVQR 3178
Cdd:smart00282 83 VSGESPGGLTILNL----DGPLYLGGLPEDLklpplpVTPGFRGCIRNLKVNG 131
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2263-2598 |
5.53e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 62.38 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2263 EQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAA 2342
Cdd:TIGR02168 715 EQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL 794
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2343 RDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMqtfspAGSKLRLVEAAEAHAQQLGQLALNLSSII-LDVNQD 2421
Cdd:TIGR02168 795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRI-----AATERRLEDLEEQIEELSEDIESLAAEIEeLEELIE 869
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2422 RLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADhtwatvvrqglvdraqqllanstALEEAMLQEQQrlglvwaALQG 2501
Cdd:TIGR02168 870 ELESELEALLNERASLEEALALLRSELEELSEELR-----------------------ELESKRSELRR-------ELEE 919
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2502 ARTQLRDVRAKKDQLEAHIQAAQAMLA----MDTDETSKKIAHAKAVAAEAQDTATRVQSQLQ--------AMQEnVERW 2569
Cdd:TIGR02168 920 LREKLAQLELRLEGLEVRIDNLQERLSeeysLTLEEAEALENKIEDDEEEARRRLKRLENKIKelgpvnlaAIEE-YEEL 998
|
330 340 350
....*....|....*....|....*....|.
gi 768017173 2570 QGQYEGLRGQ--DLGQAvldaghsVSTLEKT 2598
Cdd:TIGR02168 999 KERYDFLTAQkeDLTEA-------KETLEEA 1022
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
2262-2639 |
8.12e-09 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 62.16 E-value: 8.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAL---------QRKQELSRD- 2331
Cdd:pfam12128 271 ETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHgafldadieTAAADQEQLp 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2332 ---------NATLQATLHAARDTLASVFRL--------------LHS-LDQAKEELERLAAS----LDGARTPLLQRMQt 2383
Cdd:pfam12128 351 swqselenlEERLKALTGKHQDVTAKYNRRrskikeqnnrdiagIKDkLAKIREARDRQLAVaeddLQALESELREQLE- 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2384 fspaGSKLRLVEAAEAHAQQLGQLALNLSSII--------LDVNQDRL--TQRAIEASNAYSRILQ----AVQAAEDAAG 2449
Cdd:pfam12128 430 ----AGKLEFNEEEYRLKSRLGELKLRLNQATatpelllqLENFDERIerAREEQEAANAEVERLQselrQARKRRDQAS 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2450 QALQQAdHTWATVVRQGLVDRAQQLLANSTALEEAMLQE----QQRLGLVWAALQGARTQL------------------- 2506
Cdd:pfam12128 506 EALRQA-SRRLEERQSALDELELQLFPQAGTLLHFLRKEapdwEQSIGKVISPELLHRTDLdpevwdgsvggelnlygvk 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2507 ---------------RDVRAKKDQLEAHIQAAQAMLAmdtdETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQG 2571
Cdd:pfam12128 585 ldlkridvpewaaseEELRERLDKAEEALQSAREKQA----AAEEQLVQANGELEKASREETFARTALKNARLDLRRLFD 660
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2572 QYEGLR---GQDLGQAVLDAGHSVSTLEKTLPQLLAKL---------SILENRGVHNASL-----ALSASIGRVRELIAQ 2634
Cdd:pfam12128 661 EKQSEKdkkNKALAERKDSANERLNSLEAQLKQLDKKHqawleeqkeQKREARTEKQAYWqvvegALDAQLALLKAAIAA 740
|
....*
gi 768017173 2635 ARGAA 2639
Cdd:pfam12128 741 RRSGA 745
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
2112-2605 |
9.99e-09 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 61.77 E-value: 9.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHEtaQQLEVLEQQSTSLGQDARRLGGQAvgtRDQASQLL-------AGTEATLgHA 2184
Cdd:NF041483 50 AKLHEARRSLASRPAYDGADIGYQAE--QLLRNAQIQADQLRADAERELRDA---RAQTQRILqehaehqARLQAEL-HT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2185 KTLLAAIRaVDRTLSElMSQT--GHLglaNASAPSGEQL-LRTLAEVERLLWEMRARdlgaPQAAAEAELAAAQRLLARV 2261
Cdd:NF041483 124 EAVQRRQQ-LDQELAE-RRQTveSHV---NENVAWAEQLrARTESQARRLLDESRAE----AEQALAAARAEAERLAEEA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQALATQTRDRlAQHEAGLMdLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRD-NATLQATLH 2340
Cdd:NF041483 195 RQRLGSEAESARAEAEAILRR-ARKDAERL-LNAASTQAQEATDHAEQLRSSTAAESDQARRQAAELSRAaEQRMQEAEE 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2341 AARDTLASVFRLlhsLDQAKEELERLAASLDGARTpllQRMQTfspAGSKL-RLV-------EAAEAHAQQLGQLAlnls 2412
Cdd:NF041483 273 ALREARAEAEKV---VAEAKEAAAKQLASAESANE---QRTRT---AKEEIaRLVgeatkeaEALKAEAEQALADA---- 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2413 siilDVNQDRLTQRAIEASNAysrilqavQAAEDAAGQaLQQADHTwatvvrqglvdrAQQLLanSTALEEAmlQEQQRl 2492
Cdd:NF041483 340 ----RAEAEKLVAEAAEKART--------VAAEDTAAQ-LAKAART------------AEEVL--TKASEDA--KATTR- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2493 glvwAALQGARTQLRDVRAKKDQL--EAHIQAAQAMLAM--DTDETSKKIahakavaaeaqdtatrVQsqlqaMQENVER 2568
Cdd:NF041483 390 ----AAAEEAERIRREAEAEADRLrgEAADQAEQLKGAAkdDTKEYRAKT----------------VE-----LQEEARR 444
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 768017173 2569 WQGQYEGLRGQDL-------GQAVLDAGHSVSTLEKTLPQLLAK 2605
Cdd:NF041483 445 LRGEAEQLRAEAVaegerirGEARREAVQQIEEAARTAEELLTK 488
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2258-2525 |
1.01e-08 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 61.89 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEqlsslweenqalATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQA 2337
Cdd:COG3096 336 LNLVQT------------ALRQQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQ 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2338 TL----------HAARDTLASVFRLLH----SLDQAKEELERLAASLDGARTPLLQRMQtfspagsKLRLveaAEAHAQQ 2403
Cdd:COG3096 404 ALdvqqtraiqyQQAVQALEKARALCGlpdlTPENAEDYLAAFRAKEQQATEEVLELEQ-------KLSV---ADAARRQ 473
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2404 LGQ-LALnLSSIILDVNQDRLTQRAIEASNAYsRILQAVQAAEDAAGQAL---QQADHTWATVVRQ--GLVDRAQQLLAN 2477
Cdd:COG3096 474 FEKaYEL-VCKIAGEVERSQAWQTARELLRRY-RSQQALAQRLQQLRAQLaelEQRLRQQQNAERLleEFCQRIGQQLDA 551
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 768017173 2478 STALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQ--AAQA 2525
Cdd:COG3096 552 AEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKelAARA 601
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2879-3004 |
1.04e-08 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 56.27 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2879 LRLVSYSGVLFFLK-QQSQFLCLAVQEGSLVLLYDFGAGlkkavplqpPPPLTSASKAiqvfLLGGSRKRVLVRVERATV 2957
Cdd:pfam02210 1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSG---------PESLLSSGKN----LNDGQWHSVRVERNGNTL 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2958 ySVEQDND-------------LELADAYYLGGVPPDQLPPSLrrlfPTGGSVRGCVKGIK 3004
Cdd:pfam02210 68 -TLSVDGQtvvsslppgesllLNLNGPLYLGGLPPLLLLPAL----PVRAGFVGCIRDVR 122
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
685-735 |
1.32e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.13 E-value: 1.32e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 768017173 685 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGC 735
Cdd:pfam00053 1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
685-726 |
1.96e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 52.70 E-value: 1.96e-08
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 768017173 685 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFG 726
Cdd:smart00180 1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
|
|
| growth_prot_Scy |
NF041483 |
polarized growth protein Scy; |
2136-2564 |
2.10e-08 |
|
polarized growth protein Scy;
Pssm-ID: 469371 [Multi-domain] Cd Length: 1293 Bit Score: 60.61 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2136 HETAQQLEVLEQQST--------SLGQDARRLGGQAVGTRDQAsqlLAGTEATLGHA-KTLLAAIRAVDRTLSELmsqtg 2206
Cdd:NF041483 414 ADQAEQLKGAAKDDTkeyraktvELQEEARRLRGEAEQLRAEA---VAEGERIRGEArREAVQQIEEAARTAEEL----- 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2207 hlgLANASAPSGEqlLRTLA--EVERLLWEM--RARDLgapqaaaeaeLAAAQRLLARVQEQLSSLWEENQALATQTRdr 2282
Cdd:NF041483 486 ---LTKAKADADE--LRSTAtaESERVRTEAieRATTL----------RRQAEETLERTRAEAERLRAEAEEQAEEVR-- 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2283 lAQHEAGLMDLREALNRAV-----DATREAQELNSRNQERL---EEAL----QRKQELSRDNATLQATLhaaRDTLASVF 2350
Cdd:NF041483 549 -AAAERAARELREETERAIaarqaEAAEELTRLHTEAEERLtaaEEALadarAEAERIRREAAEETERL---RTEAAERI 624
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2351 RLLHSldQAKEELERL--AASLDGARTpllqRMQTFSPAgskLRLVEAAEAHAQQLGQLALNlssiildvNQDRLtqRAi 2428
Cdd:NF041483 625 RTLQA--QAEQEAERLrtEAAADASAA----RAEGENVA---VRLRSEAAAEAERLKSEAQE--------SADRV--RA- 684
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2429 EASNAYSRI-------LQAVQ--------AAEDAAGQALQQADHTwatvvRQGLVDRAQQLLANS-TALEEAMlQEQQRL 2492
Cdd:NF041483 685 EAAAAAERVgteaaeaLAAAQeeaarrrrEAEETLGSARAEADQE-----RERAREQSEELLASArKRVEEAQ-AEAQRL 758
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2493 ---------GLVWAALQGARtQLRD-VRAKKDQLEAHIQAAQAMLAMDTDETSKKiahakavaaeAQDTATRVQSQLQAM 2562
Cdd:NF041483 759 veeadrratELVSAAEQTAQ-QVRDsVAGLQEQAEEEIAGLRSAAEHAAERTRTE----------AQEEADRVRSDAYAE 827
|
..
gi 768017173 2563 QE 2564
Cdd:NF041483 828 RE 829
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1822-1875 |
2.13e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 52.74 E-value: 2.13e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 1822 CPCPLSVPSNnfaEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVLGSSC 1875
Cdd:pfam00053 1 CDCNPHGSLS---DTCDPETG--QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2084-2528 |
2.16e-08 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 60.70 E-value: 2.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2084 LDDLERAGALLPAIHEQLRGINASsmawARLHRLNASIADLQSQLRsplgprhETAQQLEVLEQQSTSLGQDARRLGGQA 2163
Cdd:COG4913 271 LAELEYLRAALRLWFAQRRLELLE----AELEELRAELARLEAELE-------RLEARLDALREELDELEAQIRGNGGDR 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2164 VgtrDQASQLLAGTEATLghaktllaaiRAVDRTLSELMSQTGHLGLANASapSGEQLLRTLAEVERLLwemraRDLGAP 2243
Cdd:COG4913 340 L---EQLEREIERLEREL----------EERERRRARLEALLAALGLPLPA--SAEEFAALRAEAAALL-----EALEEE 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2244 QAAAEAELAAAQRLLARVQEQLSSLWEENQALAT----------QTRDRLAQHeAG-----------LMDLRE------- 2295
Cdd:COG4913 400 LEALEEALAEAEAALRDLRRELRELEAEIASLERrksniparllALRDALAEA-LGldeaelpfvgeLIEVRPeeerwrg 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2296 ---------------------ALNRAVDATREAQELNSrnqERLEEALQRKQELSRDNATLQATL----HAARDTLASvf 2350
Cdd:COG4913 479 aiervlggfaltllvppehyaAALRWVNRLHLRGRLVY---ERVRTGLPDPERPRLDPDSLAGKLdfkpHPFRAWLEA-- 553
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2351 RLLHSLDQAK----EELERL--AASLDG------------ARTPLLQRMQT-FSPAgsklRLVEAAEAHAQQLGQLALNL 2411
Cdd:COG4913 554 ELGRRFDYVCvdspEELRRHprAITRAGqvkgngtrhekdDRRRIRSRYVLgFDNR----AKLAALEAELAELEEELAEA 629
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2412 SSIILDVNQ--DRLTQRAieasNAYSRILQAVQAAEDAAGQALQQADHTwatvvrqglvDRAQQLLANSTALEEAmlqeQ 2489
Cdd:COG4913 630 EERLEALEAelDALQERR----EALQRLAEYSWDEIDVASAEREIAELE----------AELERLDASSDDLAAL----E 691
|
490 500 510
....*....|....*....|....*....|....*....
gi 768017173 2490 QRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG4913 692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELD 730
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2286-2612 |
2.42e-08 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 60.46 E-value: 2.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2286 HEAG--LMDLREALNRAVDATREaqeLNsRNQERLE---EALQRKQELSRDNATLQATLHAARdtlasvfrllhsLDQAK 2360
Cdd:TIGR02168 175 KETErkLERTRENLDRLEDILNE---LE-RQLKSLErqaEKAERYKELKAELRELELALLVLR------------LEELR 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2361 EELERLAASLDGAR------TPLLQRMQTfSPAGSKLRLVEAAEAHAQQLGQLaLNLSSIIldvnqDRLTQRAIEASNAY 2434
Cdd:TIGR02168 239 EELEELQEELKEAEeeleelTAELQELEE-KLEELRLEVSELEEEIEELQKEL-YALANEI-----SRLEQQKQILRERL 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2435 SRILQAVQAAEDAAGQALQQADHTWATVVRqgLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKD 2514
Cdd:TIGR02168 312 ANLERQLEELEAQLEELESKLDELAEELAE--LEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVA 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2515 QLEAHIQAAQAMLamdtdetskkiahakavaaeaqdtaTRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVST 2594
Cdd:TIGR02168 390 QLELQIASLNNEI-------------------------ERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEE 444
|
330
....*....|....*...
gi 768017173 2595 LEKTLPQLLAKLSILENR 2612
Cdd:TIGR02168 445 LEEELEELQEELERLEEA 462
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2256-2568 |
2.62e-08 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 60.36 E-value: 2.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLWEENQALatqtRDRLA-------------QHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAL 2322
Cdd:PRK04863 314 RELAELNEAESDLEQDYQAA----SDHLNlvqtalrqqekieRYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAE 389
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2323 QRKQELSRDNATLQATL----------HAARDTLASVFRLLH----SLDQAKEELERLAASLDGARTPLLQrmqtfspAG 2388
Cdd:PRK04863 390 EEVDELKSQLADYQQALdvqqtraiqyQQAVQALERAKQLCGlpdlTADNAEDWLEEFQAKEQEATEELLS-------LE 462
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2389 SKLRLveaAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYS--RILQAVQAAEDAAGQALQQADHTWATVVRqg 2466
Cdd:PRK04863 463 QKLSV---AQAAHSQFEQAYQLVRKIAGEVSRSEAWDVARELLRRLReqRHLAEQLQQLRMRLSELEQRLRQQQRAER-- 537
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2467 LVDRAQQLLANSTALEEAMLQEQQRLGlvwAALQGARTQLRDV-------RAKKDQLEAHIQ----------AAQAMLAM 2529
Cdd:PRK04863 538 LLAEFCKRLGKNLDDEDELEQLQEELE---ARLESLSESVSEArerrmalRQQLEQLQARIQrlaarapawlAAQDALAR 614
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 768017173 2530 ------DTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVER 2568
Cdd:PRK04863 615 lreqsgEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDE 659
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2258-2528 |
3.80e-08 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 58.76 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEENQALATQ---TRDRLAQHEAGLMDLREALNRAVDATREAQ-ELNSRNQErLEEALQRKQELSRDNA 2333
Cdd:COG4372 47 LEQLREELEQAREELEQLEEEleqARSELEQLEEELEELNEQLQAAQAELAQAQeELESLQEE-AEELQEELEELQKERQ 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2334 TLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSS 2413
Cdd:COG4372 126 DLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2414 IILDVNQDRLTQRAIEA----SNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQ 2489
Cdd:COG4372 206 EKLIESLPRELAEELLEakdsLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL 285
|
250 260 270
....*....|....*....|....*....|....*....
gi 768017173 2490 QRLGlvwaaLQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG4372 286 EALE-----EAALELKLLALLLNLAALSLIGALEDALLA 319
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1772-1808 |
4.64e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 51.59 E-value: 4.64e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 768017173 1772 PCQCHGH---SDRCLPGSGVCVdCQHNTEGAHCERCQAGF 1808
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGY 39
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1773-1822 |
6.13e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.59 E-value: 6.13e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 1773 CQCHGH---SDRCLPGSGVCvDCQHNTEGAHCERCQAGFVssrDDPSAPCVSC 1822
Cdd:pfam00053 1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYY---GLPSDPPQGC 49
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
2062-2511 |
7.01e-08 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 58.67 E-value: 7.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2062 VPGGPVGHSIHCEVCDHCVVLLLDDLERAGALLPAIHEQLRGINASSMAWARLH---RLNASIAdLQSQLRSPLGPRHET 2138
Cdd:COG2203 253 LGRLPLGEGLAGRALRTGEPVVVNDASTDPRFAPSLRELLLALGIRSLLCVPLLvdgRLIGVLA-LYSKEPRAFTEEDLE 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2139 -----AQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANA 2213
Cdd:COG2203 332 llealADQAAIAIERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAAD 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2214 SAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDL 2293
Cdd:COG2203 412 LSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALALLAALLLLL 491
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2294 REALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGA 2373
Cdd:COG2203 492 LLLLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLTLVGVLLLLG 571
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2374 RTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQ 2453
Cdd:COG2203 572 LSVLLIELALALILALALLELLLVAVGDLLLLERDLLLLLVLLVRLLLELLVVTLELTVLVVLAAVEDSALLLRLALALA 651
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 2454 QADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRA 2511
Cdd:COG2203 652 SLVLLRALLATELDLILDSSLLLGLLLLGALLLLGGGLALLLSIGLGLGVARLLQLSV 709
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1822-1868 |
7.13e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.16 E-value: 7.13e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 768017173 1822 CPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNP 1868
Cdd:smart00180 1 CDCD---PGGSASGTCDPDTG--QCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| DAHL |
pfam19443 |
DAHL domain; The DAHL (Double All-Helical Ligand-binding) domain is a novel periplasmic ... |
2256-2457 |
9.18e-08 |
|
DAHL domain; The DAHL (Double All-Helical Ligand-binding) domain is a novel periplasmic sensory domain, which is found in major types of bacterial signal transduction proteins: histidine kinases and diguanylate cyclases/phosphodiesterases, and, occasionally in chemoreceptors. The majority of the DAHL domain-containing proteins were found in alpha-, beta-, gamma- and epsilonproteobacteria. It is also present in some cyanobacterial species. Secondary structure prediction suggested that DAHL consists predominantly of alpha-helical regions. The DAHL domain was identified in the Tlp10 chemoreceptor from the human pathogen Campylobacter jejuni and in the VirA sensor histidine kinase from a plant pathogen Agrobacterium tumefaciens. This domain recognizes Asp, Ile, purine, fumarate, malate, alpha-ketoglutarate, mannose, rhamnose, fucose, sialic acid, Arg, thiamine and galactose (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 466085 [Multi-domain] Cd Length: 222 Bit Score: 55.52 E-value: 9.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQeQLSSLWEENqALATQTR-----DRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELS- 2329
Cdd:pfam19443 11 SALRQLK-QLDAELNRD-VLKARAGllrnyDPLVAALAELRRLLERLELPSFLLAGDSAELDAALAALRAALQEKEELVe 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2330 ---RDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAAS-LDGARTP---------LLQRMQTFSPAGSKLR-LVE 2395
Cdd:pfam19443 89 rfkSQNALLRNSLAYFPTLVDELLAASPAEPALAAALNELLRAvLLYNLSSdpalaeieaLLERLEALAESAPALRaALQ 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768017173 2396 AAEAHAQQLgqlaLNLSSIIldvnqDRLTQRAIEASNAYSriLQAVQAA-EDAAGQALQQADH 2457
Cdd:pfam19443 169 LLLAHARLI----LRLLPQV-----DALLQEILALPTAAA--LEALEAAyLAAYQQALARAER 220
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2692-2810 |
9.60e-08 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 53.19 E-value: 9.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2692 MYMGSRQatGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDI--GeQFAAVSLDRTLQFGHMSVTverqmiQETKGDTVA 2769
Cdd:pfam02210 11 LYAGGGG--SDFLALELVNGRLVLRYDLGSGPESLLSSGKNLndG-QWHSVRVERNGNTLTLSVD------GQTVVSSLP 81
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 768017173 2770 PGAEGLLNLrpdDFVFYVGGYPSTFTPPPLLRFPGYRGCIE 2810
Cdd:pfam02210 82 PGESLLLNL---NGPLYLGGLPPLLLLPALPVRAGFVGCIR 119
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
737-776 |
1.18e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.82 E-value: 1.18e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 768017173 737 SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
2112-2644 |
1.30e-07 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 58.06 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLG---------------QDARR--LGGQAVGTRDQ----- 2169
Cdd:TIGR00618 358 RDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCkeldilqreqatidtRTSAFrdLQGQLAHAKKQqelqq 437
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2170 --ASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTG-----HLGLANASAPSGEQLLRtLAEVERLLwEMRARDLGA 2242
Cdd:TIGR00618 438 ryAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQtkeqiHLQETRKKAVVLARLLE-LQEEPCPL-CGSCIHPNP 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2243 PQAAAEAELAAAQRLLARVQE-------------QLSSLWEENQALATQTRdRLAQHEAGLMDLREALNRAVDATR-EAQ 2308
Cdd:TIGR00618 516 ARQDIDNPGPLTRRMQRGEQTyaqletseedvyhQLTSERKQRASLKEQMQ-EIQQSFSILTQCDNRSKEDIPNLQnITV 594
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2309 ELNSRNQERLEEALQRKQELSRDNATLQATLHAardtlasvFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAG 2388
Cdd:TIGR00618 595 RLQDLTEKLSEAEDMLACEQHALLRKLQPEQDL--------QDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALS 666
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2389 SK---LRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEAS-NAYSRILQAVQAAEDAAGQALQQADHTWATVVR 2464
Cdd:TIGR00618 667 IRvlpKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHiEEYDREFNEIENASSSLGSDLAAREDALNQSLK 746
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2465 QGlvdRAQQllanSTALEEAMLQEQQRLGLVWAALQgARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAV 2544
Cdd:TIGR00618 747 EL---MHQA----RTVLKARTEAHFNNNEEVTAALQ-TGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDI 818
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2545 AAEAQDT-ATRVQSQLQAMQEN------VERWQGQYEGLRGQ---------DLGQAVLDAGH----SVSTLEKTLPQLLA 2604
Cdd:TIGR00618 819 LNLQCETlVQEEEQFLSRLEEKsatlgeITHQLLKYEECSKQlaqltqeqaKIIQLSDKLNGinqiKIQFDGDALIKFLH 898
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 768017173 2605 KLSILENrgVHNASLALSASIGRVRELIAQARGAASKVKV 2644
Cdd:TIGR00618 899 EITLYAN--VRLANQSEGRFHGRYADSHVNARKYQGLALL 936
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
429-473 |
1.68e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 50.04 E-value: 1.68e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 429 CNC-ESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYP 473
Cdd:pfam00053 1 CDCnPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
2112-2347 |
1.81e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.70 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQL---LAGTEATLGHAKTLL 2188
Cdd:COG4942 27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELekeIAELRAELEAQKEEL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2189 AA-IRAVDRtlselMSQTGHLGLAnASAPSGEQLLRTLAEVERLLWEMRARdlgapqaaaeaelaaaQRLLARVQEQLss 2267
Cdd:COG4942 107 AElLRALYR-----LGRQPPLALL-LSPEDFLDAVRRLQYLKYLAPARREQ----------------AEELRADLAEL-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2268 lwEENQALATQTRDRLAQHEAGLMDLREALNRAVDatrEAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLA 2347
Cdd:COG4942 163 --AALRAELEAERAELEALLAELEEERAALEALKA---ERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
299-347 |
1.94e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 1.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 768017173 299 RCVCHGHADACDAKDPTDpfrLQCTCQHNTCGGTCDRCCPGFNQQPWKP 347
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGT---GQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
428-470 |
2.04e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 50.05 E-value: 2.04e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 768017173 428 RCNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS 470
Cdd:cd00055 1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| COG3899 |
COG3899 |
Predicted ATPase [General function prediction only]; |
2143-2639 |
2.04e-07 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443106 [Multi-domain] Cd Length: 1244 Bit Score: 57.56 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2143 EVLEQQ-STSLGQDARRLGGQ--AVGTRDQASQLL--AGTEATLGHAktLLAAIRAVDRTLSELMSQTG-------HLGL 2210
Cdd:COG3899 674 RALEARgPEPLEERLFELAHHlnRAGERDRAARLLlrAARRALARGA--YAEALRYLERALELLPPDPEeeyrlalLLEL 751
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2211 ANASAPSG-----EQLLRTLAEvERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSsLWEENQALATQTRDRLAQ 2285
Cdd:COG3899 752 AEALYLAGrfeeaEALLERALA-ARALAALAALRHGNPPASARAYANLGLLLLGDYEEAYE-FGELALALAERLGDRRLE 829
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2286 HEAGLM---------DLREALNRAVDATREAQELNSRnqeRLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSL 2356
Cdd:COG3899 830 ARALFNlgfilhwlgPLREALELLREALEAGLETGDA---ALALLALAAAAAAAAAAAALAAAAAAAARLLAAAAAALAA 906
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2357 DQAKEELERLAASLDGARTPLLQRMQtfspagskLRLVEAAEAHAQQLGQLALN-----------LSSIILDVNQDRLTQ 2425
Cdd:COG3899 907 AAAAAALAAAELARLAAAAAAAAALA--------LAAAAAAAAAAALAAAAAAAalaaalalaaaAAAAAAAALAAAAAA 978
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2426 RAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQ 2505
Cdd:COG3899 979 AAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAAAAAAA 1058
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2506 LRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAV 2585
Cdd:COG3899 1059 AAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAAAALLLL 1138
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2586 LDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAA 2639
Cdd:COG3899 1139 AAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAA 1192
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2084-2452 |
3.93e-07 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 56.50 E-value: 3.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2084 LDDLERAGALLPAIHEQLRGINASSMAWAR----LHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRL 2159
Cdd:PRK04863 316 LAELNEAESDLEQDYQAASDHLNLVQTALRqqekIERYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDEL 395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2160 GGQ--------------------AVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGH-LGLANASAPSG 2218
Cdd:PRK04863 396 KSQladyqqaldvqqtraiqyqqAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQkLSVAQAAHSQF 475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2219 E---QLLRTLA-EVERL-LWEMrARDlgapqaaaeaelaaaqrLLARvqeqlsslWEENQALAtqtrDRLAQHEAGLMDL 2293
Cdd:PRK04863 476 EqayQLVRKIAgEVSRSeAWDV-ARE-----------------LLRR--------LREQRHLA----EQLQQLRMRLSEL 525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2294 REALNRAVDATREAQELNSRNQERLE-----EALQRKQELSRDNATLQ-ATLHAARDTLAsvfrllHSLDQAKEELERLA 2367
Cdd:PRK04863 526 EQRLRQQQRAERLLAEFCKRLGKNLDdedelEQLQEELEARLESLSESvSEARERRMALR------QQLEQLQARIQRLA 599
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2368 asldgARTPllqRMQTFSPAGSKLR-----LVEAAEAHAQQLGQLALNLSSiiLDVNQDRLTQRaIEASNAYSRILQAVQ 2442
Cdd:PRK04863 600 -----ARAP---AWLAAQDALARLReqsgeEFEDSQDVTEYMQQLLERERE--LTVERDELAAR-KQALDEEIERLSQPG 668
|
410
....*....|
gi 768017173 2443 AAEDAAGQAL 2452
Cdd:PRK04863 669 GSEDPRLNAL 678
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
429-471 |
5.21e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.85 E-value: 5.21e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 768017173 429 CNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTG--FPSC 471
Cdd:smart00180 1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
738-776 |
5.69e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 48.46 E-value: 5.69e-07
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 738 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
|
|
| Crescentin |
pfam19220 |
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ... |
2256-2620 |
7.00e-07 |
|
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pssm-ID: 437057 [Multi-domain] Cd Length: 401 Bit Score: 54.69 E-value: 7.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLWEENQALATQ----------TRDRLAQHEAGLMDLREALN--RAVDATREAQelnSRNQER-LEEAL 2322
Cdd:pfam19220 55 ALLAQERAAYGKLRRELAGLTRRlsaaegeleeLVARLAKLEAALREAEAAKEelRIELRDKTAQ---AEALERqLAAET 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2323 QRKQELSRDNATLQATLHAARDTLAsvfRLLHSLDQAKEELERLAAslDGARtplLQ-RMQTFSPAGSKL--RLVE---A 2396
Cdd:pfam19220 132 EQNRALEEENKALREEAQAAEKALQ---RAEGELATARERLALLEQ--ENRR---LQaLSEEQAAELAELtrRLAEletQ 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2397 AEAHAQQLGQLALNLssiildVNQDRLTQRAieasnaysrilqavQAAEDAAGQALQqadhtwatvvrqglVDRAQQLLA 2476
Cdd:pfam19220 204 LDATRARLRALEGQL------AAEQAERERA--------------EAQLEEAVEAHR--------------AERASLRMK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2477 NSTALEEAMLQEQqrlglvwaALQGARTQLRDvrakkdqLEAHIQAAQAMLAmdtdETSKkiahakavaaeAQDTATRVQ 2556
Cdd:pfam19220 250 LEALTARAAATEQ--------LLAEARNQLRD-------RDEAIRAAERRLK----EASI-----------ERDTLERRL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2557 SQLQAMQENVERwqgqyeglRGQDLGQAVLDAGHSVSTLEKTLPqllAKLSILENRGVHNASLA 2620
Cdd:pfam19220 300 AGLEADLERRTQ--------QFQEMQRARAELEERAEMLTKALA---AKDAALERAEERIASLS 352
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1821-1876 |
7.21e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.50 E-value: 7.21e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 1821 SCPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVlGSSCQ 1876
Cdd:cd00055 1 PCDCN---GHGSLSGQCDPGTG--QCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
|
|
| TorS_sensor_domain |
cd16172 |
sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide ... |
2196-2487 |
7.29e-07 |
|
sensor domain of the sensor histidine kinase TorS; TorS is part of the trimethylamine-N-oxide (TMAO) reductase (Tor) pathway, which consists TorT, a periplasmic binding protein that binds TMAO; TorS, a sensor histidine kinase that forms a complex with TorT, and TorR, the response regulator. The Tor pathway is involved in regulating a cellular response to trimethylamine-N-oxide (TMAO), a terminal electron receptor in anaerobic respiration. TorS consists of a periplasmic sensor domain, as well as a HAMP domain, a histidine kinase domain, and a receiver domain.
Pssm-ID: 293930 [Multi-domain] Cd Length: 261 Bit Score: 53.74 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2196 RTLSELMSQTGHLG--LANAsapsgeqllRTLAEverllWEMRARDLGapqaaaeaelaaaqRLLARVQEQLSSLweENQ 2273
Cdd:cd16172 2 RQLSELSSRIIASAqlLANA---------DSEAE-----RQQQGRQLT--------------AQLEALLRLLKAL--GQD 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2274 ALATQTRDRLAQHEAGLMDLREALNRAVdatREAQELNSRNQERLEEALQRKQE---LSR---DNATLQATlhaARdtLA 2347
Cdd:cd16172 52 SFDSFLLSRLEQTVQEIIDNLAQLGELV---GQRLQLRQQFQQLFERLRAAAGElaqLARtqvANASTIAV---AN--VS 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2348 SVFRLL--HSLDQAKEELERLAA-SLDgartpLLQRMqtfspagSKLRLveaaeaHAQQLGQLALNLSSIildVNQDRLt 2424
Cdd:cd16172 124 GLYDLIeqNDKEAAYQALDRLIEvDLD-----LLERM-------HELRL------LALQLGNLINELRTA---SDIARL- 181
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2425 QRAIEASNAYSRILQA-VQAAED-----AAGQALQQADHtwatvvRQGLVDRAQQLLANSTALEEAMLQ 2487
Cdd:cd16172 182 AELRQQFNANLAILQRrVQAVEDpgrraQMAQLLSDLEQ------GQGLFALRRQLLALEQRLQALMQN 244
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
653-682 |
7.39e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.50 E-value: 7.39e-07
10 20 30
....*....|....*....|....*....|
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 682
Cdd:pfam00053 20 CLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2691-2815 |
9.25e-07 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 50.78 E-value: 9.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2691 VMYMGSrQATGDYMGVSLRDKKVHWVYQLGeAGPAVLSIDEDIGE-QFAAVSLDRTLQFGHMSVT-VERQMIQETKGDTV 2768
Cdd:pfam00054 10 LLYNGT-QTERDFLALELRDGRLEVSYDLG-SGAAVVRSGDKLNDgKWHSVELERNGRSGTLSVDgEARPTGESPLGATT 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 768017173 2769 APGAEGLLnlrpddfvfYVGGYPSTFTPPPLLRF-PGYRGCIEMDTLN 2815
Cdd:pfam00054 88 DLDVDGPL---------YVGGLPSLGVKKRRLAIsPSFDGCIRDVIVN 126
|
|
| MscS_porin |
pfam12795 |
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ... |
2141-2380 |
9.51e-07 |
|
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.
Pssm-ID: 432790 [Multi-domain] Cd Length: 238 Bit Score: 53.07 E-value: 9.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2141 QLEVLEQQSTSLGQDArrlggQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLG----------L 2210
Cdd:pfam12795 1 KLDELEKAKLDEAAKK-----KLLQDLQQALSLLDKIDASKQRAAAYQKALDDAPAELRELRQELAALQakaeaapkeiL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2211 ANASAPSGEQLL-----------RTLAEVERLLWEMRARdlgapqaaaeaelaaaqrlLARVQEQLSslweENQALATQT 2279
Cdd:pfam12795 76 ASLSLEELEQRLlqtsaqlqelqNQLAQLNSQLIELQTR-------------------PERAQQQLS----EARQRLQQI 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2280 RDRLAQHEAGLMDLREALNRAVDAtrEAQELNSRNQErLEEALQ---RKQELS---RDNATLQ-ATLHAARDTLASV--F 2350
Cdd:pfam12795 133 RNRLNGPAPPGEPLSEAQRWALQA--ELAALKAQIDM-LEQELLsnnNRQDLLkarRDLLTLRiQRLEQQLQALQELlnE 209
|
250 260 270
....*....|....*....|....*....|
gi 768017173 2351 RLLHSLDQAKEELERLAASLDGArTPLLQR 2380
Cdd:pfam12795 210 KRLQEAEQAVAQTEQLAEEAAGD-HPLVQQ 238
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2198-2521 |
9.84e-07 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 55.34 E-value: 9.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2198 LSELMSQtgHLGLANASAPsgEQLLRTLA----EVERllwemrardlgapqaaaeaELAAAQRLLARVQEQLSSLWEENQ 2273
Cdd:COG3096 818 FSQFVGG--HLAVAFAPDP--EAELAALRqrrsELER-------------------ELAQHRAQEQQLRQQLDQLKEQLQ 874
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2274 ALatqtrDRLAQH-----EAGLMDLREALNRAVDATREAQELNSRNQERLEealqrkqELSRDNATLQATlHAARDTLAs 2348
Cdd:COG3096 875 LL-----NKLLPQanllaDETLADRLEELREELDAAQEAQAFIQQHGKALA-------QLEPLVAVLQSD-PEQFEQLQ- 940
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2349 vfrllHSLDQAKEELERLAASLDgARTPLLQRMQTFSPAGSKLRLVEAAEahaqqlgqlaLNlssiildvnqDRLTQRai 2428
Cdd:COG3096 941 -----ADYLQAKEQQRRLKQQIF-ALSEVVQRRPHFSYEDAVGLLGENSD----------LN----------EKLRAR-- 992
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2429 easnaysriLQAVQAAEDAAGQALQQAD--HTWATVVRQGLV---DRAQQLLAnstaleeAMLQEQQRLGLVWA--ALQG 2501
Cdd:COG3096 993 ---------LEQAEEARREAREQLRQAQaqYSQYNQVLASLKssrDAKQQTLQ-------ELEQELEELGVQADaeAEER 1056
|
330 340
....*....|....*....|....*..
gi 768017173 2502 ART-------QLRDVRAKKDQLEAHIQ 2521
Cdd:COG3096 1057 ARIrrdelheELSQNRSRRSQLEKQLT 1083
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1878-1922 |
1.46e-06 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 47.31 E-value: 1.46e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 1878 CDCSGNGDpnlLFSDCDPLTGACRgCLRHTTGPRCEICAPGFYGN 1922
Cdd:smart00180 1 CDCDPGGS---ASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| RecN |
COG0497 |
DNA repair ATPase RecN [Replication, recombination and repair]; |
2271-2530 |
2.12e-06 |
|
DNA repair ATPase RecN [Replication, recombination and repair];
Pssm-ID: 440263 [Multi-domain] Cd Length: 555 Bit Score: 53.54 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2271 ENQAL---ATQTR--DRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEA-LQRKQ--ELsrDNATLQA----T 2338
Cdd:COG0497 133 EHQSLldpDAQREllDAFAGLEELLEEYREAYRAWRALKKELEELRADEAERARELdLLRFQleEL--EAAALQPgeeeE 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2339 LHAARDTLASVFRLLHSLDQAkeeLERLAASLDGArTPLLQRMqtfspagskLRLVEAAEAHAQQLGQLALNLSSIILDV 2418
Cdd:COG0497 211 LEEERRRLSNAEKLREALQEA---LEALSGGEGGA-LDLLGQA---------LRALERLAEYDPSLAELAERLESALIEL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2419 NqdrltqraiEASNAYSRILQAVQAaeDAagQALQQAD---HTWATVVR------QGLVDRAQQL---LANSTALEEAML 2486
Cdd:COG0497 278 E---------EAASELRRYLDSLEF--DP--ERLEEVEerlALLRRLARkygvtvEELLAYAEELraeLAELENSDERLE 344
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 768017173 2487 QEQQRLGLVWAALQGARTQLRDVRAKK-DQLEAHIQAAQAMLAMD 2530
Cdd:COG0497 345 ELEAELAEAEAELLEAAEKLSAARKKAaKKLEKAVTAELADLGMP 389
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2257-2565 |
2.73e-06 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 52.60 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2257 LLARVQEQLSSLWEENQALATQTRDRLAQHEaglmDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQ 2336
Cdd:COG4372 25 LIAALSEQLRKALFELDKLQEELEQLREELE----QAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2337 ATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQtfspagSKLRLVEAAEAHAQQLGQLALNLSSIIL 2416
Cdd:COG4372 101 EELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIA------EREEELKELEEQLESLQEELAALEQELQ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2417 DVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVW 2496
Cdd:COG4372 175 ALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEE 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2497 AALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQEN 2565
Cdd:COG4372 255 VILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLE 323
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2292-2667 |
3.24e-06 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 53.42 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2292 DLREALNRAVDATRE---AQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASV---FRLLHSLDQAKEELER 2365
Cdd:PRK04863 280 ERRVHLEEALELRRElytSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLVqtaLRQQEKIERYQADLEE 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2366 LAASLDGartpllqrmQTFSPAGSKLRlVEAAEAHAQQLGQLALNLSSIILDVNQ--DRLTQRAIeasnAYSrilQAVQA 2443
Cdd:PRK04863 360 LEERLEE---------QNEVVEEADEQ-QEENEARAEAAEEEVDELKSQLADYQQalDVQQTRAI----QYQ---QAVQA 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2444 AEDAAGQaLQQADHTWAtvvrqGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALqgartqlrdvrakkdqlEAHIQAA 2523
Cdd:PRK04863 423 LERAKQL-CGLPDLTAD-----NAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAH-----------------SQFEQAY 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2524 QAMLAMdTDETSkkiahakavaaeaqdtatRVQSQLQAMQenVERwqgQYEGLRGQDlgqavldaghsvstleKTLPQLL 2603
Cdd:PRK04863 480 QLVRKI-AGEVS------------------RSEAWDVARE--LLR---RLREQRHLA----------------EQLQQLR 519
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2604 AKLSILENRgvhnasLALSAsigRVRELIAQargaaskvkvpmkFNGRSGVQLRTPRDLADLAA 2667
Cdd:PRK04863 520 MRLSELEQR------LRQQQ---RAERLLAE-------------FCKRLGKNLDDEDELEQLQE 561
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2321-2612 |
3.51e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 53.14 E-value: 3.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2321 ALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPL-LQRMQtfspagsKLRLVEAAEA 2399
Cdd:TIGR02168 672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQIsALRKD-------LARLEAEVEQ 744
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2400 HAQQLGQLALNLSSiiLDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADhtwatVVRQGLVDRAQQLlansT 2479
Cdd:TIGR02168 745 LEERIAQLSKELTE--LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELK-----ALREALDELRAEL----T 813
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2480 ALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAmDTDETSKKIahakavaaeaQDTATRVQSQL 2559
Cdd:TIGR02168 814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE-ELEELIEEL----------ESELEALLNER 882
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 2560 QAMQENVERWQGQYEGLRGQ--DLGQAVLDAGHSVSTLEKTLPQLLAKLSILENR 2612
Cdd:TIGR02168 883 ASLEEALALLRSELEELSEElrELESKRSELRRELEELREKLAQLELRLEGLEVR 937
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
2112-2371 |
4.15e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 53.14 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRsplgpRHETAQQLevLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTL---- 2187
Cdd:TIGR02168 719 KELEELSRQISALRKDLA-----RLEAEVEQ--LEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELeaqi 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2188 ---LAAIRAVDRTLSELMSQTGHLGLANASAPSG-EQLLRTLAEVERLLWEM--RARDLGAPQAAAEAELAAAQRLLARV 2261
Cdd:TIGR02168 792 eqlKEELKALREALDELRAELTLLNEEAANLRERlESLERRIAATERRLEDLeeQIEELSEDIESLAAEIEELEELIEEL 871
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEE----NQALATQtRDRLAQHEAglmDLREALNRAVDATREAQELNSRN---QERLEEALQRKQEL-SRDNA 2333
Cdd:TIGR02168 872 ESELEALLNEraslEEALALL-RSELEELSE---ELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLqERLSE 947
|
250 260 270
....*....|....*....|....*....|....*...
gi 768017173 2334 TLQATLHAArdtLASVFRLLHSLDQAKEELERLAASLD 2371
Cdd:TIGR02168 948 EYSLTLEEA---EALENKIEDDEEEARRRLKRLENKIK 982
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2083-2528 |
4.31e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 53.00 E-value: 4.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALLPAIHEQLRGINASSMA--WARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLG 2160
Cdd:COG4913 307 LEAELERLEARLDALREELDELEAQIRGngGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALR 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2161 GQAVGTRDQASQLLAGTEATLGHAKT----LLAAIRAVDRTLSELMSQTG---------------HLGLANASAP----- 2216
Cdd:COG4913 387 AEAAALLEALEEELEALEEALAEAEAalrdLRRELRELEAEIASLERRKSniparllalrdalaeALGLDEAELPfvgel 466
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2217 ------------SGEQLLRTLA---------------EVERLLWEMRAR--DLGAPQAAAEAELAAAQRLLARVQeqlss 2267
Cdd:COG4913 467 ievrpeeerwrgAIERVLGGFAltllvppehyaaalrWVNRLHLRGRLVyeRVRTGLPDPERPRLDPDSLAGKLD----- 541
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2268 lWEENQAlatqtRDRLAQHEAGLMDLR-----EALNRAVDA-TREAQ--------ELNSR------------NQERLEEA 2321
Cdd:COG4913 542 -FKPHPF-----RAWLEAELGRRFDYVcvdspEELRRHPRAiTRAGQvkgngtrhEKDDRrrirsryvlgfdNRAKLAAL 615
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2322 LQRKQElsrdnatLQATLHAARDTLAsvfrllhsldQAKEELERLAASLDgartpLLQRMQTFSPAGSKLRLVEAAEAHA 2401
Cdd:COG4913 616 EAELAE-------LEEELAEAEERLE----------ALEAELDALQERRE-----ALQRLAEYSWDEIDVASAEREIAEL 673
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2402 QQlgQLA-LNLSSIILDVNQDRLTQRAIEasnaysriLQAVQAAEDAAGQALQQADHTWATVVRQglVDRAQQLLANstA 2480
Cdd:COG4913 674 EA--ELErLDASSDDLAALEEQLEELEAE--------LEELEEELDELKGEIGRLEKELEQAEEE--LDELQDRLEA--A 739
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 768017173 2481 LEEAMLQEQQRLGLVWAALQGARtQLRDVRAkkdQLEAHIQAAQAMLA 2528
Cdd:COG4913 740 EDLARLELRALLEERFAAALGDA-VERELRE---NLEERIDALRARLN 783
|
|
| TNFRSF16 |
cd13416 |
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
1753-1822 |
4.33e-06 |
|
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.
Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 49.61 E-value: 4.33e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1753 ECAPGFYRDVKGlflGRCVPCQchghsdRCLPGSGVCVDCQHNTEgAHCERCQAGFVSSRDDPSAPCVSC 1822
Cdd:cd13416 79 ECAYGYYLDEDS---GTCEPCT------VCPPGQGVVQSCGPNQD-TVCEACPEGTYSDEDSSTDPCLPC 138
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2280-2519 |
6.09e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 52.61 E-value: 6.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2280 RDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLeEALQRKQELS---RDNATLQATLHAARDTLAsvfrllhSL 2356
Cdd:COG4913 609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERR-EALQRLAEYSwdeIDVASAEREIAELEAELE-------RL 680
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2357 DQAKEELERLAASLDGARtpllQRMQtfspagsklRLVEAAEAHAQQLGQLALNLSSI--ILDVNQDRLTQRAIEASNAY 2434
Cdd:COG4913 681 DASSDDLAALEEQLEELE----AELE---------ELEEELDELKGEIGRLEKELEQAeeELDELQDRLEAAEDLARLEL 747
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2435 SRILQAV--QAAEDAAGQALQQadhtWATVVRQGLVDRAQQLlanSTALEEAMLQEQQRlglvW-AALQGARTQL---RD 2508
Cdd:COG4913 748 RALLEERfaAALGDAVERELRE----NLEERIDALRARLNRA---EEELERAMRAFNRE----WpAETADLDADLeslPE 816
|
250
....*....|.
gi 768017173 2509 VRAKKDQLEAH 2519
Cdd:COG4913 817 YLALLDRLEED 827
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2120-2414 |
6.35e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 52.61 E-value: 6.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2120 SIADLQSQLRSPLGPRHETAQQLevleqqstsLgqdARRLGGQAVGT-----RDQ---ASQLLAGTEATLGHAKTLLAAI 2191
Cdd:COG4913 174 SFSAYLARLRRRLGIGSEKALRL---------L---HKTQSFKPIGDlddfvREYmleEPDTFEAADALVEHFDDLERAH 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2192 RAVDRTLSelmsQTGHLGLANASAPSGEQLLRTLAEVERL-----LWEMRARDlgapqaaaeaelaaaqRLLARVQEQLS 2266
Cdd:COG4913 242 EALEDARE----QIELLEPIRELAERYAAARERLAELEYLraalrLWFAQRRL----------------ELLEAELEELR 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2267 SLWEENQALATQTRDRLAQHEAGLMDLREALNRAvdATREAQELNSRnQERLEEALQRKQELSRDNATLQATLHAARDTL 2346
Cdd:COG4913 302 AELARLEAELERLEARLDALREELDELEAQIRGN--GGDRLEQLERE-IERLERELEERERRRARLEALLAALGLPLPAS 378
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2347 ASVF-RLLHSLDQAKEELERLAASLDGARTPLLQRmqtfspagsKLRLVEAAEAHAQQLGQLALNLSSI 2414
Cdd:COG4913 379 AEEFaALRAEAAALLEALEEELEALEEALAEAEAA---------LRDLRRELRELEAEIASLERRKSNI 438
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
2315-2528 |
8.41e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 51.30 E-value: 8.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2315 QERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTfspagSKLRLV 2394
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-----LEKEIA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2395 EAAEAHAQQLGQLALNLSSIILDVNQDRLT--------QRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVV--R 2464
Cdd:COG4942 94 ELRAELEAQKEELAELLRALYRLGRQPPLAlllspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEaeR 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2465 QGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG4942 174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
653-683 |
1.02e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 45.04 E-value: 1.02e-05
10 20 30
....*....|....*....|....*....|.
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGLsPSNPEGCT 683
Cdd:cd00055 21 CECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2310-2639 |
1.20e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 51.48 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2310 LNSRNQER---LEEA------LQRKQE-LSRdnatlqatlhaardtlasvfrllhsLDQAKEELERL---AASLDGARTP 2376
Cdd:COG1196 150 IEAKPEERraiIEEAagiskyKERKEEaERK-------------------------LEATEENLERLediLGELERQLEP 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2377 L------LQRMQTFSpagSKLRLVEAA------EAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRI-LQAVQA 2443
Cdd:COG1196 205 LerqaekAERYRELK---EELKELEAEllllklRELEAELEELEAELEELEAELEELEAELAELEAELEELRLeLEELEL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2444 AEDAAGQALQQADHTWATVVRQG--LVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQ 2521
Cdd:COG1196 282 ELEEAQAEEYELLAELARLEQDIarLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2522 AAQAMLAMDT---DETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKT 2598
Cdd:COG1196 362 EAEEALLEAEaelAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 768017173 2599 LPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAA 2639
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL 482
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
3062-3176 |
1.34e-05 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 47.03 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3062 FHSAQDSALLYYRAS--PDGLCqVSLQQGRVSLQL-----LRTEVKTQAGFADGAPHYVAF-YSNATGVwLYVDDQlqqm 3133
Cdd:pfam02210 1 FRTRQPNGLLLYAGGggSDFLA-LELVNGRLVLRYdlgsgPESLLSSGKNLNDGQWHSVRVeRNGNTLT-LSVDGQ---- 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 768017173 3134 KPHRGPPPELQPQPEGPPRLLLGGLPESGTIY------NFSGCISNVFV 3176
Cdd:pfam02210 75 TVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPalpvraGFVGCIRDVRV 123
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
2117-2343 |
1.58e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 50.79 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2117 LNASIADLQSQLRsplgprhETAQQLEVLEQQSTSLGqdarrLGGQAvgtrDQASQLLAGTEATLGHAKTLLAAIRAVDR 2196
Cdd:COG3206 180 LEEQLPELRKELE-------EAEAALEEFRQKNGLVD-----LSEEA----KLLLQQLSELESQLAEARAELAEAEARLA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2197 TLSELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRAR------DLgapqaaaeaelaaaQRLLARVQEQLSSLWE 2270
Cdd:COG3206 244 ALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARytpnhpDV--------------IALRAQIAALRAQLQQ 309
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2271 ENQALATQTRDRLAQHEAGLMDLREALNRavdATREAQELNSRNQERLEeaLQRKQELSRDN-ATLQATLHAAR 2343
Cdd:COG3206 310 EAQRILASLEAELEALQAREASLQAQLAQ---LEARLAELPELEAELRR--LEREVEVARELyESLLQRLEEAR 378
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
2258-2455 |
1.58e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 50.21 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEE--------NQALA--TQTRDRLAQHEAGLMDLREALNRAVDA----TREAQE-------------- 2309
Cdd:COG3883 32 LEAAQAELDALQAEleelneeyNELQAelEALQAEIDKLQAEIAEAEAEIEERREElgerARALYRsggsvsyldvllgs 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2310 ---------------LNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGAR 2374
Cdd:COG3883 112 esfsdfldrlsalskIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2375 TPLLQRMQtfspagSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQ 2454
Cdd:COG3883 192 AAAEAQLA------ELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAA 265
|
.
gi 768017173 2455 A 2455
Cdd:COG3883 266 G 266
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1773-1808 |
1.70e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 44.22 E-value: 1.70e-05
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 1773 CQCHG---HSDRCLPGSGVCvDCQHNTEGAHCERCQAGF 1808
Cdd:smart00180 1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGY 38
|
|
| PspA_IM30 |
pfam04012 |
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ... |
2344-2604 |
2.00e-05 |
|
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.
Pssm-ID: 461130 [Multi-domain] Cd Length: 215 Bit Score: 48.52 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2344 DTLASVFR-LLHSLDQAKEELERLaasLDGArtplLQRMQtfspagskLRLVEAAEAHAQQLGQLALNlssiildvnQDR 2422
Cdd:pfam04012 3 KRLGRLVRaNIHEGLDKAEDPEKM---LEQA----IRDMQ--------SELVKARQALAQTIARQKQL---------ERR 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2423 LTQRAIEASNAYSRILQAV-QAAEDAAGQALQQAdhtwatvvrqglvdraqQLLANSTALEEAMLQEQQRLGL-VWAALQ 2500
Cdd:pfam04012 59 LEQQTEQAKKLEEKAQAALtKGNEELAREALAEK-----------------KSLEKQAEALETQLAQQRSAVEqLRKQLA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2501 GARTQLRDVRAKKDQLEAHIQAAQAMLAMDTdeTSKKIahakavaaeaqDTATRVqSQLQAMQENVERWQGQ---YEGLR 2577
Cdd:pfam04012 122 ALETKIQQLKAKKNLLKARLKAAKAQEAVQT--SLGSL-----------STSSAT-DSFERIEEKIEEREARadaAAELA 187
|
250 260
....*....|....*....|....*...
gi 768017173 2578 G-QDLGQAVLDAGHSVSTLEKTLPQLLA 2604
Cdd:pfam04012 188 SaVDLDAKLEQAGIQMEVSEDVLARLKA 215
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
2284-2594 |
2.09e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 49.83 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2284 AQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLAsvfRLLHSLDQAKEEL 2363
Cdd:COG3883 12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA---EAEAEIEERREEL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2364 ERLAASL--DGARTPLLQRM---QTFSPAGSKLRLVEAAEAHAQQlgqlalnlssIILDVNQDRltQRAIEASNAYSRIL 2438
Cdd:COG3883 89 GERARALyrSGGSVSYLDVLlgsESFSDFLDRLSALSKIADADAD----------LLEELKADK--AELEAKKAELEAKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2439 QAVQAAEDAAGQALQQAdhtwatvvrQGLVDRAQQLLANSTAlEEAMLQEQ-QRLGLVWAALQGARTQLRDvrAKKDQLE 2517
Cdd:COG3883 157 AELEALKAELEAAKAEL---------EAQQAEQEALLAQLSA-EEAAAEAQlAELEAELAAAEAAAAAAAA--AAAAAAA 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768017173 2518 AHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVST 2594
Cdd:COG3883 225 AAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAAGAAAGAAGAGAAAASAAGGGAGGAGGGGGGGGAASG 301
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
738-776 |
2.20e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 44.27 E-value: 2.20e-05
10 20 30
....*....|....*....|....*....|....*....
gi 768017173 738 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 776
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2139-2351 |
2.71e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 50.30 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2139 AQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAI--RAVDRTLSELMSQtghlgLANASAP 2216
Cdd:COG4913 609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIdvASAEREIAELEAE-----LERLDAS 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2217 SGEqllrtLAEVERLLWEMRARdlgapqaaaeaelaaaqrlLARVQEQLSSLWEEnqalATQTRDRLAQHEAGLMDLREA 2296
Cdd:COG4913 684 SDD-----LAALEEQLEELEAE-------------------LEELEEELDELKGE----IGRLEKELEQAEEELDELQDR 735
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2297 LNRAVDATREAQ--ELNSRNQERLEEALQRK--QELSRDNATLQATLHAARDTLASVFR 2351
Cdd:COG4913 736 LEAAEDLARLELraLLEERFAAALGDAVERElrENLEERIDALRARLNRAEEELERAMR 794
|
|
| Lebercilin |
pfam15619 |
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ... |
2258-2365 |
2.79e-05 |
|
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.
Pssm-ID: 464776 [Multi-domain] Cd Length: 193 Bit Score: 47.59 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEENQALATQTR-----------------DRLAQHEAGLMDLREALNRAVDATREA-QELNSRNQE--R 2317
Cdd:pfam15619 20 LAELQSKLEELRKENRLLKRLQKrqekalgkyegteselpQLIARHNEEVRVLRERLRRLQEKERDLeRKLKEKEAEllR 99
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 768017173 2318 LEEALQRKQELSRDnATLqatlhAARDTLAsvfrllHSLDQAKEELER 2365
Cdd:pfam15619 100 LRDQLKRLEKLSED-KNL-----AEREELQ------KKLEQLEAKLED 135
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
358-421 |
2.94e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 43.88 E-value: 2.94e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 358 SCNCYGHAtdcyydpevdrrrasqSLDGT-YQGGGVCIdCQHHTTGVNCERCLPGFYRSPNHPLD 421
Cdd:cd00055 1 PCDCNGHG----------------SLSGQcDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| MscS_porin |
pfam12795 |
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ... |
2273-2527 |
2.96e-05 |
|
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.
Pssm-ID: 432790 [Multi-domain] Cd Length: 238 Bit Score: 48.45 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2273 QALATQTRDRLAQHEAgLMDLREALNRaVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAA---RDTLASV 2349
Cdd:pfam12795 3 DELEKAKLDEAAKKKL-LQDLQQALSL-LDKIDASKQRAAAYQKALDDAPAELRELRQELAALQAKAEAApkeILASLSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2350 FRLLHSLDQAKEELERLAASLDGARTpLLQRMQTfSPAGSKLRLVEAAeahaQQLGQLALNLSSiiLDVNQDRLTQraie 2429
Cdd:pfam12795 81 EELEQRLLQTSAQLQELQNQLAQLNS-QLIELQT-RPERAQQQLSEAR----QRLQQIRNRLNG--PAPPGEPLSE---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2430 asnaysrilqavqaAEDAAGQALQQAdhtwatvvRQGLVDRAQQLLANSTALEEAmlqeqqrlglvwaalqgARTQLRDV 2509
Cdd:pfam12795 149 --------------AQRWALQAELAA--------LKAQIDMLEQELLSNNNRQDL-----------------LKARRDLL 189
|
250
....*....|....*...
gi 768017173 2510 RAKKDQLEAHIQAAQAML 2527
Cdd:pfam12795 190 TLRIQRLEQQLQALQELL 207
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2885-3011 |
3.21e-05 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 46.16 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2885 SGVLFFLKQQSQ--FLCLAVQEGSLVLLYDFGAGLKkavpLQPPPPLTSASKAIQVFLLGgSRKRVLVRVERATVYSVEQ 2962
Cdd:pfam00054 7 SGLLLYNGTQTErdFLALELRDGRLEVSYDLGSGAA----VVRSGDKLNDGKWHSVELER-NGRSGTLSVDGEARPTGES 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 768017173 2963 ----DNDLELADAYYLGGVPPDQLppsLRRLFPTGGSVRGCVKGIKALGKYVD 3011
Cdd:pfam00054 82 plgaTTDLDVDGPLYVGGLPSLGV---KKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
2273-2639 |
3.22e-05 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 49.81 E-value: 3.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2273 QALATQTRDRL--AQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASVF 2350
Cdd:COG2203 334 EALADQAAIAIerARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLS 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2351 RLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEA 2430
Cdd:COG2203 414 GLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALALLAALLLLLLL 493
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2431 SNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVR 2510
Cdd:COG2203 494 LLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLTLVGVLLLLGLS 573
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2511 AKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGH 2590
Cdd:COG2203 574 VLLIELALALILALALLELLLVAVGDLLLLERDLLLLLVLLVRLLLELLVVTLELTVLVVLAAVEDSALLLRLALALASL 653
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 768017173 2591 SVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAA 2639
Cdd:COG2203 654 VLLRALLATELDLILDSSLLLGLLLLGALLLLGGGLALLLSIGLGLGVA 702
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2083-2518 |
4.24e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.55 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQ 2162
Cdd:COG1196 381 LEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2163 AVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGA 2242
Cdd:COG1196 461 LLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2243 PQAAAeaelaaaQRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEAL 2322
Cdd:COG1196 541 EAALA-------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADA 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2323 QRKQelsRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTpllqrmqtfspAGSKLRLVEAAEAHAQ 2402
Cdd:COG1196 614 RYYV---LGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLT-----------GGSRRELLAALLEAEA 679
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2403 QLGQLALNLSSIILDVNQDRLTQRAIEasnaysriLQAVQAAEDAAGQALQQADhtwatvVRQGLVDRAQQLLANSTALE 2482
Cdd:COG1196 680 ELEELAERLAEEELELEEALLAEEEEE--------RELAEAEEERLEEELEEEA------LEEQLEAEREELLEELLEEE 745
|
410 420 430
....*....|....*....|....*....|....*.
gi 768017173 2483 EAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEA 2518
Cdd:COG1196 746 ELLEEEALEELPEPPDLEELERELERLEREIEALGP 781
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
359-426 |
5.28e-05 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 43.11 E-value: 5.28e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 359 CNCYGHATdcyydpevdrrrasqSLDGTYQGGGVCiDCQHHTTGVNCERCLPGFYRSPNhplDSPHVC 426
Cdd:pfam00053 1 CDCNPHGS---------------LSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLPS---DPPQGC 49
|
|
| GAF |
COG2203 |
GAF domain [Signal transduction mechanisms]; |
2256-2644 |
5.54e-05 |
|
GAF domain [Signal transduction mechanisms];
Pssm-ID: 441805 [Multi-domain] Cd Length: 712 Bit Score: 49.04 E-value: 5.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLsslweenqALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRKQELSRDNATL 2335
Cdd:COG2203 331 ELLEALADQA--------AIAIERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAEL 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2336 QATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSII 2415
Cdd:COG2203 403 LLLLLDAADLSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAVILLALA 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2416 LDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLV 2495
Cdd:COG2203 483 LLAALLLLLLLLLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLLERELLT 562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2496 WAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEG 2575
Cdd:COG2203 563 LVGVLLLLGLSVLLIELALALILALALLELLLVAVGDLLLLERDLLLLLVLLVRLLLELLVVTLELTVLVVLAAVEDSAL 642
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2576 LRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAASKVKV 2644
Cdd:COG2203 643 LLRLALALASLVLLRALLATELDLILDSSLLLGLLLLGALLLLGGGLALLLSIGLGLGVARLLQLSVLE 711
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2075-2371 |
5.65e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.16 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2075 VCDHCVVLLLDDLERAGALLPAIHEQLRGINASSMAWARlhrlnASIADLQSQLRSPLgprheTAQQLEVLEQQSTSLGQ 2154
Cdd:COG1196 522 LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAA-----AAIEYLKAAKAGRA-----TFLPLDKIRARAALAAA 591
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2155 DARRLGGQAVGTRDQASQLLAGTEATLGhaKTLLAAIRAVDRTLSelmsqtghlGLANASAPSGEQLLRTLAEVERLLWE 2234
Cdd:COG1196 592 LARGAIGAAVDLVASDLREADARYYVLG--DTLLGRTLVAARLEA---------ALRRAVTLAGRLREVTLEGEGGSAGG 660
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2235 MRARdlgapqaaaeaelaaaqrllARVQEQLSSLwEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRN 2314
Cdd:COG1196 661 SLTG--------------------GSRRELLAAL-LEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 2315 QERLEEALQRKQELSRDNATLQATLHAA-RDTLASVFRLLHSLDQAKEELERLAASLD 2371
Cdd:COG1196 720 ELEEEALEEQLEAEREELLEELLEEEELlEEEALEELPEPPDLEELERELERLEREIE 777
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
653-682 |
7.47e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 42.68 E-value: 7.47e-05
10 20 30
....*....|....*....|....*....|
gi 768017173 653 CMCRAHVEGPSCDRCKPGFWGlspSNPEGC 682
Cdd:smart00180 20 CECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| TNFRSF4 |
cd13406 |
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
1892-1978 |
8.12e-05 |
|
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.
Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 45.47 E-value: 8.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1892 DCDPLTGACRGClRHTTGPRCEICAPGFYGNAL---LPGNCTRCDCTPCGTE--ACDPHSG-HCLCKAGVT-------GR 1958
Cdd:cd13406 17 ECPPGEGMESRC-TGTQDTVCSPCEPGFYNEAVnyePCKPCTQCNQRSGSEEkqKCTKTSDtVCRCRPGTQpldsykpGV 95
|
90 100
....*....|....*....|
gi 768017173 1959 RCDRCQEGHFGFDGCGGCRP 1978
Cdd:cd13406 96 DCVPCPPGHFSRGDNQACKP 115
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2121-2519 |
8.86e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 47.97 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2121 IADLQSQLRSPLGPRHETAQQLEVLEQQstslgqdarrlggqavgtRDQASQLLAGTEATLGHAKTLLAAIRavdrtlSE 2200
Cdd:COG4372 26 IAALSEQLRKALFELDKLQEELEQLREE------------------LEQAREELEQLEEELEQARSELEQLE------EE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2201 LmsqtghlglanasapsgEQLLRTLAEVERLLWEMRARdlgapqaaaeaelaaaqrlLARVQEQLSSLWEENQALATQtR 2280
Cdd:COG4372 82 L-----------------EELNEQLQAAQAELAQAQEE-------------------LESLQEEAEELQEELEELQKE-R 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2281 DRLAQHEAGLMDLREALNRAVDA-TREAQELNSR---NQERLEEALQRKQELSRDNAT--LQATLHAARDTLASVFRLLH 2354
Cdd:COG4372 125 QDLEQQRKQLEAQIAELQSEIAErEEELKELEEQlesLQEELAALEQELQALSEAEAEqaLDELLKEANRNAEKEEELAE 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2355 SLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEAsNAY 2434
Cdd:COG4372 205 AEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEI-AAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2435 SRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQLLANSTALEEAMLQEQQRlGLVWAALQGARTQLRDVRAKKD 2514
Cdd:COG4372 284 ELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELA-DLLQLLLVGLLDNDVLELLSKG 362
|
....*
gi 768017173 2515 QLEAH 2519
Cdd:COG4372 363 AEAGV 367
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
2112-2381 |
1.02e-04 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 48.41 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2112 ARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLgqdaRRLGGQAVGTRDQ-ASQLLAGTEATLGHAKTLLAA 2190
Cdd:COG3096 836 AELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLL----NKLLPQANLLADEtLADRLEELREELDAAQEAQAF 911
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2191 IRAVDRTLSELMSQTGHLglanASAP-SGEQLLRTLAEVERLLWEMRARdlgapqaaaeaeLAAAQRLLARVQ----EQL 2265
Cdd:COG3096 912 IQQHGKALAQLEPLVAVL----QSDPeQFEQLQADYLQAKEQQRRLKQQ------------IFALSEVVQRRPhfsyEDA 975
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2266 SSLWEENQALATQTRDRLAQHEAGLMDLREAL----NRAVDATREAQELNSR---NQERLEEALQRKQELS-RDNATLQA 2337
Cdd:COG3096 976 VGLLGENSDLNEKLRARLEQAEEARREAREQLrqaqAQYSQYNQVLASLKSSrdaKQQTLQELEQELEELGvQADAEAEE 1055
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 768017173 2338 TLHAARDTLASvfrLLHSLDQAKEELERLAASLDGARTPLLQRM 2381
Cdd:COG3096 1056 RARIRRDELHE---ELSQNRSRRSQLEKQLTRCEAEMDSLQKRL 1096
|
|
| PspA |
COG1842 |
Phage shock protein A [Transcription, Signal transduction mechanisms]; |
2393-2606 |
1.67e-04 |
|
Phage shock protein A [Transcription, Signal transduction mechanisms];
Pssm-ID: 441447 [Multi-domain] Cd Length: 217 Bit Score: 45.97 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2393 LVEAAEAHAQQLGqlalnlssiildvNQDRLTQRAIEASNA----YSRILQAVQAA-EDAAGQALQQ-ADHtwatvvrQG 2466
Cdd:COG1842 39 LVEARQALAQVIA-------------NQKRLERQLEELEAEaekwEEKARLALEKGrEDLAREALERkAEL-------EA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2467 LVDRAQQLLANSTALEEAMLQEQQRLglvwaalqgaRTQLRDVRAKKDQLEAHIQAAQAMLAMdtDETSKKIahakavaa 2546
Cdd:COG1842 99 QAEALEAQLAQLEEQVEKLKEALRQL----------ESKLEELKAKKDTLKARAKAAKAQEKV--NEALSGI-------- 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 2547 eaqdTATRVQSQLQAMQENVERWQGQYEGL----RGQDLGQ--AVLDAGHSVstlEKTLPQLLAKL 2606
Cdd:COG1842 159 ----DSDDATSALERMEEKIEEMEARAEAAaelaAGDSLDDelAELEADSEV---EDELAALKAKM 217
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2116-2528 |
1.76e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 47.64 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2116 RLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSL---------GQDA-RRLG---GQAVGTRDQASQLLAGT---EA 2179
Cdd:PRK04863 562 ELEARLESLSESVSEARERRMALRQQLEQLQARIQRLaarapawlaAQDAlARLReqsGEEFEDSQDVTEYMQQLlerER 641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2180 TLGHAKTLLAA-IRAVDRTLSELmsqtghlglanaSAPSGEQL--LRTLAE---------------------VERLLWEM 2235
Cdd:PRK04863 642 ELTVERDELAArKQALDEEIERL------------SQPGGSEDprLNALAErfggvllseiyddvsledapyFSALYGPA 709
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2236 R----ARDLGapqaaaeaelaaaqrllaRVQEQLSSLWE--ENQALATQTRDRLAQ--HEAglmdlrEALNRAV------ 2301
Cdd:PRK04863 710 RhaivVPDLS------------------DAAEQLAGLEDcpEDLYLIEGDPDSFDDsvFSV------EELEKAVvvkiad 765
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2302 ---------------DATREAQeLNSRNQERlEEALQRKQELSRDNATLQATLHAARDTLAS----VFR-----LLHSLD 2357
Cdd:PRK04863 766 rqwrysrfpevplfgRAAREKR-IEQLRAER-EELAERYATLSFDVQKLQRLHQAFSRFIGShlavAFEadpeaELRQLN 843
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2358 QAKEELERLAASLDGARtpLLQRMQtfspagsklrlVEAAEAHAQQLGQLALNLSsiILDVN--QDRLTQ------RAIE 2429
Cdd:PRK04863 844 RRRVELERALADHESQE--QQQRSQ-----------LEQAKEGLSALNRLLPRLN--LLADEtlADRVEEireqldEAEE 908
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2430 A-------SNAYSRI------LQAVQAAEDAAGQALQQADHTWATVVRQG-----LVDR--------AQQLLANSTALEE 2483
Cdd:PRK04863 909 AkrfvqqhGNALAQLepivsvLQSDPEQFEQLKQDYQQAQQTQRDAKQQAfalteVVQRrahfsyedAAEMLAKNSDLNE 988
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 768017173 2484 AMlqeQQRLGLVWAALQGARTQLRDVRAKKDQ-------LEAHIQAAQAMLA 2528
Cdd:PRK04863 989 KL---RQRLEQAEQERTRAREQLRQAQAQLAQynqvlasLKSSYDAKRQMLQ 1037
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
2026-2054 |
1.79e-04 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 41.57 E-value: 1.79e-04
10 20 30
....*....|....*....|....*....|....
gi 768017173 2026 CQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:pfam00053 1 CDCNPhgslsDTCDPETGQCLCKPGVTGRHCDRC 34
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
2390-2612 |
1.80e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.32 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2390 KLRLVEAAEAHAQQLGQLALNLSSIiLDVNQDRLT------------QRAIEASNAYSR--ILQAVQAAEDAAGQALQQa 2455
Cdd:COG3206 102 KLNLDEDPLGEEASREAAIERLRKN-LTVEPVKGSnvieisytspdpELAAAVANALAEayLEQNLELRREEARKALEF- 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2456 dhtwatvvrqgLVDRAQQLLANSTALEEAMLQEQQRLGLVWAA---------LQGARTQLRDVRAKKDQLEAHIQAAQAM 2526
Cdd:COG3206 180 -----------LEEQLPELRKELEEAEAALEEFRQKNGLVDLSeeaklllqqLSELESQLAEARAELAEAEARLAALRAQ 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2527 LAMDTDETSKKIAHAKAVAAEAQdtATRVQSQLQAMQEN-------VERWQGQYEGLRGQ---DLGQAVLDAGHSVSTLE 2596
Cdd:COG3206 249 LGSGPDALPELLQSPVIQQLRAQ--LAELEAELAELSARytpnhpdVIALRAQIAALRAQlqqEAQRILASLEAELEALQ 326
|
250
....*....|....*.
gi 768017173 2597 KTLPQLLAKLSILENR 2612
Cdd:COG3206 327 AREASLQAQLAQLEAR 342
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
2025-2054 |
2.71e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 41.19 E-value: 2.71e-04
10 20 30
....*....|....*....|....*....|....*
gi 768017173 2025 RCQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:cd00055 1 PCDCNGhgslsGQCDPGTGQCECKPNTTGRRCDRC 35
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
300-345 |
2.96e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 2.96e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 768017173 300 CVCH--GHADacdakDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPW 345
Cdd:smart00180 1 CDCDpgGSAS-----GTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
2026-2054 |
2.99e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 2.99e-04
10 20 30
....*....|....*....|....*....|....
gi 768017173 2026 CQCP-----GGRCDPHTGRCNCPPGLSGERCDTC 2054
Cdd:smart00180 1 CDCDpggsaSGTCDPDTGQCECKPNVTGRRCDRC 34
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
387-416 |
3.43e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 40.76 E-value: 3.43e-04
10 20 30
....*....|....*....|....*....|
gi 768017173 387 YQGGGVCiDCQHHTTGVNCERCLPGFYRSP 416
Cdd:smart00180 14 DPDTGQC-ECKPNVTGRRCDRCAPGYYGDG 42
|
|
| HAP1_N |
pfam04849 |
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found ... |
2262-2366 |
3.76e-04 |
|
HAP1 N-terminal conserved region; This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.
Pssm-ID: 461455 [Multi-domain] Cd Length: 309 Bit Score: 45.79 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQAL-------ATQTrDRLAQHEAGLM---------------DLREALNRAVDATREAQELNSRNQERLE 2319
Cdd:pfam04849 170 QEKLRGLEEENLKLrseashlKTET-DTYEEKEQQLMsdcveqlseanqqmaELSEELARKMEENLRQQEEITSLLAQIV 248
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 768017173 2320 EALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERL 2366
Cdd:pfam04849 249 DLQHKCKELGIENEELQQHLQASKEAQRQLTSELQELQDRYAECLGM 295
|
|
| type_I_sec_TolC |
TIGR01844 |
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ... |
2258-2530 |
3.87e-04 |
|
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]
Pssm-ID: 273829 [Multi-domain] Cd Length: 415 Bit Score: 45.83 E-value: 3.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSslweenqalatQTRDRLAQHEAGLMDLREAlnRAVDATREAQELNSRNQerLEEALQRKQELSRDNATLQA 2337
Cdd:TIGR01844 136 LAALKEQLD-----------LARARFDVGLGTRTDVLQA--EARYASARAQLIQAQNN--LDDAKAQLRRLVGQPELAPL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2338 TLHAARDtlasvfRLLHSLDQAKEELER-----LAA--SLDGARTPLLQR----MQTFSPAGSKLRLVEAAEAHAQQLGQ 2406
Cdd:TIGR01844 201 AVPSFPA------ELPEPLDQLLEIAEAsnpllLAAqaAVDAARYQVEQAraghLPTLSLTASTGNSDTSSGGSGNSDSD 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2407 LAlnlsSIILDVN----QDRLTQRAIEAsnAYSRILQAVQAAEDAAGQALQQADHTWATVV--RQGLVDRAQQLLANSTA 2480
Cdd:TIGR01844 275 TY----SVGLNVSiplyQGGATSAQVRQ--AAHQLNQSRSTLESQKRTVRQQVRNAWSNLNaaAASVQAYEQQVASAQKA 348
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 768017173 2481 LeEAMLQEQQ---R--LGLVWA--ALQGARTQLrdVRAKKDQLEAHIQAAQAMLAMD 2530
Cdd:TIGR01844 349 L-DAYRQEYQvgtRtlLDVLNAeqELYQARQEL--ANARYDYLQAQLNLLSATGTLN 402
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
2073-2365 |
4.12e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 46.60 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2073 CEVCDHcvvlLLDDLERAGaLLPAIHEQLRGINAssmawaRLHRLNASIADLQSQLR---------SPLGPRHETAQQLE 2143
Cdd:PRK03918 438 CPVCGR----ELTEEHRKE-LLEEYTAELKRIEK------ELKEIEEKERKLRKELRelekvlkkeSELIKLKELAEQLK 506
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2144 VLEQQSTSLG--------QDARRLGGQAVGTRDQASQL---LAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLAn 2212
Cdd:PRK03918 507 ELEEKLKKYNleelekkaEEYEKLKEKLIKLKGEIKSLkkeLEKLEELKKKLAELEKKLDELEEELAELLKELEELGFE- 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2213 asapSGEQLLRTLAEVERLLWE-MRARDlgapqaaaeaelaaAQRLLARVQEQLSSLWEEnqalATQTRDRLAQHEAGLM 2291
Cdd:PRK03918 586 ----SVEELEERLKELEPFYNEyLELKD--------------AEKELEREEKELKKLEEE----LDKAFEELAETEKRLE 643
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 2292 DLREALNravdatreaqELNSR-NQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELER 2365
Cdd:PRK03918 644 ELRKELE----------ELEKKySEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708
|
|
| Apolipoprotein |
pfam01442 |
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a ... |
2257-2404 |
5.51e-04 |
|
Apolipoprotein A1/A4/E domain; These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Apolipoprotein A-I. Apolipoprotein A-IV. Apolipoprotein E.
Pssm-ID: 460211 [Multi-domain] Cd Length: 175 Bit Score: 43.79 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2257 LLARVQEQLSSLweenqalatqtRDRLAQHEAglmDLREALNRAVD--------ATREAQELNSRNQERLEEALQRKQEL 2328
Cdd:pfam01442 38 LRERLQKDLEEV-----------RAKLEPYLE---ELQAKLGQNVEelrqrlepYTEELRKRLNADAEELQEKLAPYGEE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2329 SRDNA-----TLQATLHAARDtlasvfRLLHSLDQAKEEL-ERLAASLDGARTPLLQRMQtfspagsklRLVEAAEAHAQ 2402
Cdd:pfam01442 104 LRERLeqnvdALRARLAPYAE------ELRQKLAERLEELkESLAPYAEEVQAQLSQRLQ---------ELREKLEPQAE 168
|
..
gi 768017173 2403 QL 2404
Cdd:pfam01442 169 DL 170
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2258-2537 |
5.62e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 46.21 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEENQALAtQTRDRLAQHEAGLMD-LREALNRAVDATREAQELN---SRNQERLEEALQRKQELSRDNA 2333
Cdd:TIGR02169 676 LQRLRERLEGLKRELSSLQ-SELRRIENRLDELSQeLSDASRKIGEIEKEIEQLEqeeEKLKERLEELEEDLSSLEQEIE 754
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2334 TLQATLHAARDTLASVFRLLHSLdqaKEELERLAASLDGARTPLLQRM-----QTFSPAGSKLRLVEAAEAHAQQLGQLA 2408
Cdd:TIGR02169 755 NVKSELKELEARIEELEEDLHKL---EEALNDLEARLSHSRIPEIQAElskleEEVSRIEARLREIEQKLNRLTLEKEYL 831
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2409 ----LNLSSIILDV-NQDRLTQRAIEASNAYSRILQAV----QAAE-----------------DAAGQALQQADHTWATV 2462
Cdd:TIGR02169 832 ekeiQELQEQRIDLkEQIKSIEKEIENLNGKKEELEEEleelEAALrdlesrlgdlkkerdelEAQLRELERKIEELEAQ 911
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2463 vrqglVDRAQQLLANSTALEEAMLQEQQRLGLVWAALQ---GARTQLRDVRAKKDQLEAHIQAAQA--MLAMDTDETSKK 2537
Cdd:TIGR02169 912 -----IEKKRKRLSELKAKLEALEEELSEIEDPKGEDEeipEEELSLEDVQAELQRVEEEIRALEPvnMLAIQEYEEVLK 986
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
2084-2564 |
5.86e-04 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 45.95 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2084 LDDLERAgalLPAihEQLRGinassmAWARLHRLNASIAD-----------LQSQLRSPLGPRHETAQQLEVLEQQSTSL 2152
Cdd:PRK10246 280 LAALSLA---QPA--RQLRP------HWERIQEQSAALAHtrqqieevntrLQSTMALRARIRHHAAKQSAELQAQQQSL 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2153 GQ-----DARRLGGQAV-GTRDQASQL------LAGTEATLGHAKTLLAAIRAVDRTLSelmsqtghlglANASAPSGEQ 2220
Cdd:PRK10246 349 NTwlaehDRFRQWNNELaGWRAQFSQQtsdreqLRQWQQQLTHAEQKLNALPAITLTLT-----------ADEVAAALAQ 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2221 LLRTLAEVERLLwemrardlgapqaaaeaelaaaqRLLARVQEQLSSLwEENQALATQTRDRLAQHEAGLMDLRealnra 2300
Cdd:PRK10246 418 HAEQRPLRQRLV-----------------------ALHGQIVPQQKRL-AQLQVAIQNVTQEQTQRNAALNEMR------ 467
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2301 vdatreaQELNSRNQERLE-----EALQRKQELSRDNATLQA---------TLHAARDTLASVF-----RLLHSLDQAKE 2361
Cdd:PRK10246 468 -------QRYKEKTQQLADvkticEQEARIKDLEAQRAQLQAgqpcplcgsTSHPAVEAYQALEpgvnqSRLDALEKEVK 540
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2362 ELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTqraieASNAYSRIL--- 2438
Cdd:PRK10246 541 KLGEEGAALRGQLDALTKQLQRDESEAQSLRQEEQALTQQWQAVCASLNITLQPQDDIQPWLD-----AQEEHERQLrll 615
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2439 ---QAVQAAEDAAGQALQQADHTWATvVRQGLVDraqQLLANSTAL-----EEAMLQEQQRLGLVWAALQgarTQLRDVR 2510
Cdd:PRK10246 616 sqrHELQGQIAAHNQQIIQYQQQIEQ-RQQQLLT---ALAGYALTLpqedeEASWLATRQQEAQSWQQRQ---NELTALQ 688
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2511 AKKDQLEAHIQAAQAMLAMDTDETSkkiaHAKAVAAEAQDTATRVQSQLQAMQE 2564
Cdd:PRK10246 689 NRIQQLTPLLETLPQSDDLPHSEET----VALDNWRQVHEQCLSLHSQLQTLQQ 738
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2258-2492 |
7.06e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 45.68 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEENQALATQTRDRL--AQHEAGLMDLREALNRAVDATREAQELNSR---NQERLEEALQRKQELSRDN 2332
Cdd:COG4913 636 LEAELDALQERREALQRLAEYSWDEIdvASAEREIAELEAELERLDASSDDLAALEEQleeLEAELEELEEELDELKGEI 715
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2333 ATLQATLHAARDtlasvfrllhSLDQAKEELERLAASLDGARTPLLQRMqtfspagsklRLVEAAEAHAQQLGQlalNLS 2412
Cdd:COG4913 716 GRLEKELEQAEE----------ELDELQDRLEAAEDLARLELRALLEER----------FAAALGDAVERELRE---NLE 772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2413 SII--LDVNQDRLTQRAIEASNAYSR----ILQAVQAAEDAAGQALQQADhtwaTVVRQGLVDRAQQLLAnstALEEAML 2486
Cdd:COG4913 773 ERIdaLRARLNRAEEELERAMRAFNRewpaETADLDADLESLPEYLALLD----RLEEDGLPEYEERFKE---LLNENSI 845
|
....*.
gi 768017173 2487 QEQQRL 2492
Cdd:COG4913 846 EFVADL 851
|
|
| LapB |
COG2956 |
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ... |
2293-2533 |
7.44e-04 |
|
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442196 [Multi-domain] Cd Length: 275 Bit Score: 44.33 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2293 LREALNRAVDATREAQELNS-------------RNQERLEEALQ-RKQELSRDNATLQATLHaardtLASVFRLLHSLDQ 2358
Cdd:COG2956 20 LNGQPDKAIDLLEEALELDPetveahlalgnlyRRRGEYDRAIRiHQKLLERDPDRAEALLE-----LAQDYLKAGLLDR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2359 AKEELERLAASLDGARTPLLQRMQTFspagSKLRLVEAAEAHAQQLgqLALNLSSIILDVNQDRLTQRAIEASNAYSRIL 2438
Cdd:COG2956 95 AEELLEKLLELDPDDAEALRLLAEIY----EQEGDWEKAIEVLERL--LKLGPENAHAYCELAELYLEQGDYDEAIEALE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2439 QAVQAAEDAAGQALQQADhtwaTVVRQGLVDRAQQLLANSTALEEAMLQEQQRLGLVWAAL---QGARTQLRDVRAKKDQ 2515
Cdd:COG2956 169 KALKLDPDCARALLLLAE----LYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLgdpEEALELLRKALELDPS 244
|
250
....*....|....*...
gi 768017173 2516 LEAHIQAAQAMLAMDTDE 2533
Cdd:COG2956 245 DDLLLALADLLERKEGLE 262
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
2262-2581 |
7.48e-04 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 45.73 E-value: 7.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRavdaTREAQELNSRNQERLEEALQRKQELSRdnatLQATLHA 2341
Cdd:TIGR00618 200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQ----TQQSHAYLTQKREAQEEQLKKQQLLKQ----LRARIEE 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2342 ARDTLASVFRLLHSLDQAK------EELERLaASLDGARTPLLQRMQtfspagSKLRLVEAAEAHAQQLGQLALNLSSii 2415
Cdd:TIGR00618 272 LRAQEAVLEETQERINRARkaaplaAHIKAV-TQIEQQAQRIHTELQ------SKMRSRAKLLMKRAAHVKQQSSIEE-- 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2416 ldvnQDRLTQraieasnaysRILQAVQAAEDAAGQALQQADH-TWATVVRQGLVDRAQQL-----LANSTALEEAMLQEQ 2489
Cdd:TIGR00618 343 ----QRRLLQ----------TLHSQEIHIRDAHEVATSIREIsCQQHTLTQHIHTLQQQKttltqKLQSLCKELDILQRE 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2490 QrlglvwaALQGARTQ-LRDVRAKKDQLEAHIQAAQAMLAMD----TDETSKKIAHAKAVAAEAQDTATRVQ--SQLQAM 2562
Cdd:TIGR00618 409 Q-------ATIDTRTSaFRDLQGQLAHAKKQQELQQRYAELCaaaiTCTAQCEKLEKIHLQESAQSLKEREQqlQTKEQI 481
|
330
....*....|....*....
gi 768017173 2563 QENVERwQGQYEGLRGQDL 2581
Cdd:TIGR00618 482 HLQETR-KKAVVLARLLEL 499
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
2376-2529 |
9.49e-04 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 44.34 E-value: 9.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2376 PLLQrmqtFSPAGSKLRLVEAAEAHAQQLGQLALNLSSI----ILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQA 2451
Cdd:pfam00529 47 VLFQ----LDPTDYQAALDSAEAQLAKAQAQVARLQAELdrlqALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2452 LQQADHTWAT-----VVRQGLVDRAQQLLANSTALeeamLQEQQRLGLVWA-ALQGARTQLRDVRAKKDQLEAHIQAAQA 2525
Cdd:pfam00529 123 QIDLARRRVLapiggISRESLVTAGALVAQAQANL----LATVAQLDQIYVqITQSAAENQAEVRSELSGAQLQIAEAEA 198
|
....
gi 768017173 2526 MLAM 2529
Cdd:pfam00529 199 ELKL 202
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
2185-2399 |
9.72e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.01 E-value: 9.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2185 KTLLAAIRAVDRTLSELMSQTGHLGLANASAPSGEQL--LRT-LAEVERLLWEMRARdlgapqaaaeaelaaaqrlLARV 2261
Cdd:COG3206 185 PELRKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQLseLESqLAEARAELAEAEAR-------------------LAAL 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLWEENQALAT-----QTRDRLAQHEAGLMDLREALN----RAVDATREAQELNSRNQERLEEALQrkqELSRDN 2332
Cdd:COG3206 246 RAQLGSGPDALPELLQspviqQLRAQLAELEAELAELSARYTpnhpDVIALRAQIAALRAQLQQEAQRILA---SLEAEL 322
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2333 ATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGAR---TPLLQRMQ----TFSPAGSKLRLVEAAEA 2399
Cdd:COG3206 323 EALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARelyESLLQRLEearlAEALTVGNVRVIDPAVV 396
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
300-344 |
1.08e-03 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 39.26 E-value: 1.08e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 768017173 300 CVCHGHADAcdaKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQP 344
Cdd:pfam00053 1 CDCNPHGSL---SDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLP 42
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2430-2585 |
1.11e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.51 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2430 ASNAYSRILQAVQAAEDAAGQALQQADHTWATV--VRQGLVDRAQQLLANSTALEEAMLQEQQRLglvwAALQGARTQLR 2507
Cdd:COG4372 29 LSEQLRKALFELDKLQEELEQLREELEQAREELeqLEEELEQARSELEQLEEELEELNEQLQAAQ----AELAQAQEELE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2508 DVRAKKDQLEAHIQAAQA---MLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQA 2584
Cdd:COG4372 105 SLQEEAEELQEELEELQKerqDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQA 184
|
.
gi 768017173 2585 V 2585
Cdd:COG4372 185 L 185
|
|
| PRK04778 |
PRK04778 |
septation ring formation regulator EzrA; Provisional |
2262-2492 |
1.27e-03 |
|
septation ring formation regulator EzrA; Provisional
Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 44.44 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2262 QEQLSSLweenQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQElnsrNQERLEEALQ--RKQELS-RDNA-TLQA 2337
Cdd:PRK04778 354 EKQLESL----EKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEK----EQEKLSEMLQglRKDELEaREKLeRYRN 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2338 TLHAARDTLASVfRL-------LHSLDQAKEELERLAASLDgaRTPLlqRMQTFSpagsklRLVEAAEAHAQQLGQLALN 2410
Cdd:PRK04778 426 KLHEIKRYLEKS-NLpglpedyLEMFFEVSDEIEALAEELE--EKPI--NMEAVN------RLLEEATEDVETLEEETEE 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2411 LssiildVNQDRLTQRAIEASNAY----SRILQAVQAAE------------DAAGQALQQADhtwatvvrQGLVDRaqql 2474
Cdd:PRK04778 495 L------VENATLTEQLIQYANRYrsdnEEVAEALNEAErlfreydykaalEIIATALEKVE--------PGVTKR---- 556
|
250
....*....|....*...
gi 768017173 2475 lanstaLEEAMLQEQQRL 2492
Cdd:PRK04778 557 ------IEDSYEKEKETI 568
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
2305-2474 |
1.41e-03 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 43.80 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2305 REAQELNSRNQErLEEAL----QRKQELSRDNATLQATLHAARdtlasvfrllhsldQAKEELERLAASLDGARTPLLQR 2380
Cdd:PRK09039 53 SALDRLNSQIAE-LADLLslerQGNQDLQDSVANLRASLSAAE--------------AERSRLQALLAELAGAGAAAEGR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2381 MQTFSPAgsklrLVEAAEAHAQQLGQLALnlssiildVNQDrltqraIEASNaysRILQAVQAAEDAAGQALQQADHTWA 2460
Cdd:PRK09039 118 AGELAQE-----LDSEKQVSARALAQVEL--------LNQQ------IAALR---RQLAALEAALDASEKRDRESQAKIA 175
|
170
....*....|....*..
gi 768017173 2461 TVVRQ---GLVDRAQQL 2474
Cdd:PRK09039 176 DLGRRlnvALAQRVQEL 192
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
2300-2528 |
1.51e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 44.05 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2300 AVDATREAQELNSRNQERLEEALQRKQELSRDNATLQATLHAARDTLASvfrllhsLDQAKEELERLAASLDGARTPLLQ 2379
Cdd:COG3883 11 PAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE-------LEALQAEIDKLQAEIAEAEAEIEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2380 RMQTFspagsklrlveAAEAHAQQLGQLALNLSSIILDVNqdrltqraiEASNAYSRiLQAVQAAEDAAGQALQQADHTw 2459
Cdd:COG3883 84 RREEL-----------GERARALYRSGGSVSYLDVLLGSE---------SFSDFLDR-LSALSKIADADADLLEELKAD- 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2460 atvvrQGLVDRAQQLLANSTALEEAMLQEQQrlglvwAALQGARTQLRDVRAKKDQLEAHIQAAQAMLA 2528
Cdd:COG3883 142 -----KAELEAKKAELEAKLAELEALKAELE------AAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2110-2406 |
1.81e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 44.29 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2110 AWARLHRLNASIADLQSQLRsplgprhETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATlghaktlla 2189
Cdd:TIGR02169 225 GYELLKEKEALERQKEAIER-------QLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEE--------- 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2190 aIRAVDRTLSELMSQTghlglanasapsgEQLLRTLAEVERLLWEMRARdlgapqaaAEAELAAAQRLLARVqEQLSSLW 2269
Cdd:TIGR02169 289 -QLRVKEKIGELEAEI-------------ASLERSIAEKERELEDAEER--------LAKLEAEIDKLLAEI-EELEREI 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2270 EENQALATQTRDRLAQHEAGLMDLR---EALNRAVDATREaqELNSRnQERLEEA--------------LQRKQELSRDN 2332
Cdd:TIGR02169 346 EEERKRRDKLTEEYAELKEELEDLRaelEEVDKEFAETRD--ELKDY-REKLEKLkreinelkreldrlQEELQRLSEEL 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2333 ATLQATLHAARDTLASVFRLLHSLD----QAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVE----AAEAHAQQL 2404
Cdd:TIGR02169 423 ADLNAAIAGIEAKINELEEEKEDKAleikKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQrelaEAEAQARAS 502
|
..
gi 768017173 2405 GQ 2406
Cdd:TIGR02169 503 EE 504
|
|
| AtpF |
COG0711 |
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ... |
2294-2429 |
2.06e-03 |
|
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase
Pssm-ID: 440475 [Multi-domain] Cd Length: 152 Bit Score: 41.31 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2294 REALNRAVDATREAQELNSRNQERLEEALQRKQELsRDNATLQATLHAARdtlasvfrllhSLDQAKEELERLAASldgA 2373
Cdd:COG0711 37 ADGLAEAERAKEEAEAALAEYEEKLAEARAEAAEI-IAEARKEAEAIAEE-----------AKAEAEAEAERIIAQ---A 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768017173 2374 RtpllqrmqtfspagsklRLVEAAEAHA-----QQLGQLALNLSSIILDVN-----QDRLTQRAIE 2429
Cdd:COG0711 102 E-----------------AEIEQERAKAlaelrAEVADLAVAIAEKILGKEldaaaQAALVDRFIA 150
|
|
| TolA |
COG3064 |
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
2269-2744 |
2.06e-03 |
|
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 43.87 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2269 WEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERLEE-ALQRKQELSRDNATLQAtlHAARDTLA 2347
Cdd:COG3064 4 ALEEKAAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEeAREAKAEAEQRAAELAA--EAAKKLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2348 SVFRLLHSLDQAKEELERLA----ASLDGARTPLLQRMQTFSPAgsKLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRL 2423
Cdd:COG3064 82 AEKAAAEAEKKAAAEKAKAAkeaeAAAAAEKAAAAAEKEKAEEA--KRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2424 TQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRA--QQLLANSTALEEAMLQEQQRLGLVWAALQG 2501
Cdd:COG3064 160 AAAAAAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAaaAAADAALLALAVAARAAAASREAALAAVEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2502 ARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAEAQDTATRVQSQLQAMQENVERWQGQYEGLRGQDL 2581
Cdd:COG3064 240 TEEAALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2582 GQAVLDAGHSVSTLEKTL--PQLLAKLSILENRGVHNASLALSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTP 2659
Cdd:COG3064 320 AAAAAGALVVRGGGAASLeaALSLLAAGAAAAAAGAGALATGALGDALAAEAAGALLLGKLADVEEAAGAGILAAAGGGG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2660 RDLADLAAYTALKFYLQGPEPEPGQGTED-RFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAGPAVLSIDEDIGEQFA 2738
Cdd:COG3064 400 LLGLRLDLGAALLEAASAVELRVLLALAGaAGAVVALLVKLVADLAGGLVGIGKALTGDADALLGILKAVALDGGAVLAD 479
|
....*.
gi 768017173 2739 AVSLDR 2744
Cdd:COG3064 480 LLLLGG 485
|
|
| PspA_IM30 |
pfam04012 |
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ... |
2261-2408 |
2.61e-03 |
|
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.
Pssm-ID: 461130 [Multi-domain] Cd Length: 215 Bit Score: 42.36 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2261 VQEQLSSLWEENQALATQtrdrLAQHEAGLMDLREALNRAVDATREAQELNSRNQERL-EEALQRKQELSRDNATLQATL 2339
Cdd:pfam04012 31 IRDMQSELVKARQALAQT----IARQKQLERRLEQQTEQAKKLEEKAQAALTKGNEELaREALAEKKSLEKQAEALETQL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2340 HAARDTLASVFRLLHSLD----QAKEELERLAASLDGAR-----------------TPLLQRMQTfspagsklrLVEAAE 2398
Cdd:pfam04012 107 AQQRSAVEQLRKQLAALEtkiqQLKAKKNLLKARLKAAKaqeavqtslgslstssaTDSFERIEE---------KIEERE 177
|
170
....*....|
gi 768017173 2399 AHAQQLGQLA 2408
Cdd:pfam04012 178 ARADAAAELA 187
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
2307-2527 |
2.71e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 43.75 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2307 AQELNSRN--QERLEEALQRKQeLSRDNATLQATLhaaRDTLAsvfrLLHSLDQAKEELERLAASLDGArtPllQRMQTF 2384
Cdd:PRK11281 32 NGDLPTEAdvQAQLDALNKQKL-LEAEDKLVQQDL---EQTLA----LLDKIDRQKEETEQLKQQLAQA--P--AKLRQA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2385 SPAGSKLRLVEAAEAhAQQLGQLAL-NLSSIILDVNQD-RLTQRAIEASNAYSRILQA----VQAAEDAAGQALQQADHT 2458
Cdd:PRK11281 100 QAELEALKDDNDEET-RETLSTLSLrQLESRLAQTLDQlQNAQNDLAEYNSQLVSLQTqperAQAALYANSQRLQQIRNL 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768017173 2459 WATVVRQGLVDRA--QQLLANSTALEEAMLQEQQRLglvwaaLQGArTQLRD--------VRAKKDQLEAHIQAAQAML 2527
Cdd:PRK11281 179 LKGGKVGGKALRPsqRVLLQAEQALLNAQNDLQRKS------LEGN-TQLQDllqkqrdyLTARIQRLEHQLQLLQEAI 250
|
|
| NIT |
pfam08376 |
Nitrate and nitrite sensing; The nitrate- and nitrite sensing domain (NIT) is found in ... |
2276-2521 |
2.74e-03 |
|
Nitrate and nitrite sensing; The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.
Pssm-ID: 462453 [Multi-domain] Cd Length: 227 Bit Score: 42.48 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2276 ATQTRDRLAQHeaglmdlREALNRAVDATREAQ---ELNSRNQERLEEALQRKQELS--RDNATLQATlhAARDTLASVF 2350
Cdd:pfam08376 20 GGRFAAELAAQ-------RAATDAALAALRAALaelALPARLADRLAALLRALDQLPalRRQVDAGAL--SALEALAAYT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2351 RLLHSLdqakeeLERLAASLDGARTP-LLQRMQTFSPagsklrLVEAAEAHAQQLGQLALNLSSiildvnqDRLTQraie 2429
Cdd:pfam08376 91 ELIAAL------LDLVDELAAGSPDPeLARQLRALAA------LLRAKEAAGQERALLAAALAA-------GRFTA---- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2430 asNAYSRILQAVQAAEDAAGQALQQADHTWATvvrqglvdRAQQLLANSTALEEAMLQEQQRLGLVWAALQGAR-TQLRD 2508
Cdd:pfam08376 148 --AEYRRFLSLVAAQRAALAEFRAAATPEQRA--------LYDATVTGPAVAAAERLRDRLVDAAAWFAASTARiDLLRE 217
|
250
....*....|...
gi 768017173 2509 VRakkDQLEAHIQ 2521
Cdd:pfam08376 218 VE---DRLADDLA 227
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2083-2394 |
2.74e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 43.75 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2083 LLDDLERAGALLPAIHEQLRGINASSMAWARLHRLN----------ASIADLQSQLRSPLgprhETAQQLEVLEQQSTSL 2152
Cdd:COG4913 622 LEEELAEAEERLEALEAELDALQERREALQRLAEYSwdeidvasaeREIAELEAELERLD----ASSDDLAALEEQLEEL 697
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2153 GQDARRLGGQavgtRDQASQLLAGTEATLGHAKTLLAAIRAVDRTLSELMSQTGHLGLANA-SAPSGEQLLRTLAEverl 2231
Cdd:COG4913 698 EAELEELEEE----LDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERfAAALGDAVERELRE---- 769
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2232 lwemrardlgapqaaaeaelaaaqRLLARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELN 2311
Cdd:COG4913 770 ------------------------NLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLE 825
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2312 S----RNQERLEEALQRKQElsRDNATLQATLHAARDTlasvfrllhsldqAKEELERLAASLdgARTPllqrmqtFSPa 2387
Cdd:COG4913 826 EdglpEYEERFKELLNENSI--EFVADLLSKLRRAIRE-------------IKERIDPLNDSL--KRIP-------FGP- 880
|
....*..
gi 768017173 2388 GSKLRLV 2394
Cdd:COG4913 881 GRYLRLE 887
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
2438-2528 |
2.77e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 43.18 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2438 LQAVQAAEDAAGQALQQADHTWATVvrQGLVDRAQQLLANSTAleEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLE 2517
Cdd:TIGR04320 270 LAAAQTALNTAQAALTSAQTAYAAA--QAALATAQKELANAQA--QALQTAQNNLATAQAALANAEARLAKAKEALANLN 345
|
90
....*....|.
gi 768017173 2518 AHIQAAQAMLA 2528
Cdd:TIGR04320 346 ADLAKKQAALD 356
|
|
| BAR_SNX |
cd07596 |
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins; BAR domains are dimerization, lipid ... |
2270-2403 |
2.89e-03 |
|
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Pssm-ID: 153280 [Multi-domain] Cd Length: 218 Bit Score: 41.96 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2270 EENQALaTQTRDRLAQHEAGLMDLREALNRAVDATRE----------------------AQELN---SRNQERLEEALQR 2324
Cdd:cd07596 1 EEDQEF-EEAKDYILKLEEQLKKLSKQAQRLVKRRRElgsalgefgkaliklakceeevGGELGealSKLGKAAEELSSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2325 KQELSR-DNATLQATLH-------AARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEA 2396
Cdd:cd07596 80 SEAQANqELVKLLEPLKeylrycqAVKETLDDRADALLTLQSLKKDLASKKAQLEKLKAAPGIKPAKVEELEEELEEAES 159
|
....*..
gi 768017173 2397 AEAHAQQ 2403
Cdd:cd07596 160 ALEEARK 166
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
2135-2457 |
3.19e-03 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 43.64 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2135 RHETAQ-QLEVLEQQSTslgqdarrlgGQAVGTRDQASQLLAGTEATLGHAKTLLAAiravdrtlselmsqtghlglana 2213
Cdd:PRK10246 192 QHKSARtELEKLQAQAS----------GVALLTPEQVQSLTASLQVLTDEEKQLLTA----------------------- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2214 sapsgEQLLRtlaevERLLWEMRARDLGAPQAAAEAELAAAQRLLARVQEQLSSLweENQALATQTR---DRLAQHEAGL 2290
Cdd:PRK10246 239 -----QQQQQ-----QSLNWLTRLDELQQEASRRQQALQQALAAEEKAQPQLAAL--SLAQPARQLRphwERIQEQSAAL 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2291 MDLRealnravdatREAQELNSrnqeRLEEALQRKQELSRDNATLQATLHAARDTLAS------VFRLLHS--------- 2355
Cdd:PRK10246 307 AHTR----------QQIEEVNT----RLQSTMALRARIRHHAAKQSAELQAQQQSLNTwlaehdRFRQWNNelagwraqf 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2356 --LDQAKEELERLAASLDGARtpllQRMQTFSPAGSKLRLVEAAEAHAQQ-----LGQLALNLSSIILDVnQDRLTQRAI 2428
Cdd:PRK10246 373 sqQTSDREQLRQWQQQLTHAE----QKLNALPAITLTLTADEVAAALAQHaeqrpLRQRLVALHGQIVPQ-QKRLAQLQV 447
|
330 340
....*....|....*....|....*....
gi 768017173 2429 EASNAYSRILQAVQAAEDAAGQALQQADH 2457
Cdd:PRK10246 448 AIQNVTQEQTQRNAALNEMRQRYKEKTQQ 476
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
2263-2636 |
3.68e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 43.08 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2263 EQLSSLWEENQALATQTRdrlaqheagLMDLREALNRAVDATREAQELNSRNQERLE--EALQRKQELSRDNAT--LQAT 2338
Cdd:COG3206 71 SGLSSLSASDSPLETQIE---------ILKSRPVLERVVDKLNLDEDPLGEEASREAaiERLRKNLTVEPVKGSnvIEIS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2339 L------HAAR--DTLASVFrLLHSLDQAKEELERLAASLDGaRTPLLQRmqtfspagsKLRLVEAA-EAHAQQLGQLAL 2409
Cdd:COG3206 142 YtspdpeLAAAvaNALAEAY-LEQNLELRREEARKALEFLEE-QLPELRK---------ELEEAEAAlEEFRQKNGLVDL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2410 NLSSIILDVNQDRLTQRAIEASNAysriLQAVQAAEDAAGQALQQADHTWATVVRQGLVdraQQLLANSTALEEAMLQEQ 2489
Cdd:COG3206 211 SEEAKLLLQQLSELESQLAEARAE----LAEAEARLAALRAQLGSGPDALPELLQSPVI---QQLRAQLAELEAELAELS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2490 QRLGlvwaalqgarTQLRDVRAKKDQleahIQAAQAMLAMDTDETSKKIahakavaaeaQDTATRVQSQLQAMQENVERW 2569
Cdd:COG3206 284 ARYT----------PNHPDVIALRAQ----IAALRAQLQQEAQRILASL----------EAELEALQAREASLQAQLAQL 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768017173 2570 QGQYEGLRGQDLGQAVLDagHSVSTLEKTLPQLLAKLSilenrgvhNASLALSASIGRVReLIAQAR 2636
Cdd:COG3206 340 EARLAELPELEAELRRLE--REVEVARELYESLLQRLE--------EARLAEALTVGNVR-VIDPAV 395
|
|
| TolC |
COG1538 |
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; |
2264-2627 |
4.33e-03 |
|
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441147 [Multi-domain] Cd Length: 367 Bit Score: 42.33 E-value: 4.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2264 QLSSLWEenQALATQTRdrLAQHEAGLMDLREALNRAVDATREAQEL----NSRNQERLEEALQRKQELSRDNATLQATL 2339
Cdd:COG1538 1 TLDELIE--RALANNPD--LRAARARVEAARAQLRQARAGLLPSQELdlggKRRARIEAAKAQAEAAEADLRAARLDLAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2340 HAARdTLASVFRLLHSLDQAKEELERLAASLD--------GARTPL-LQRMQTFSpAGSKLRLVEAAEAHAQQLGQLALN 2410
Cdd:COG1538 77 EVAQ-AYFDLLAAQEQLALAEENLALAEELLElararyeaGLASRLdVLQAEAQL-AQARAQLAQAEAQLAQARNALALL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2411 L-----SSIILDVNQDRLTQRAIEASNAYSRILQ---AVQAAEDAAGQALQQADHTWA------TVVRQGLVDRAQQLLA 2476
Cdd:COG1538 155 LglpppAPLDLPDPLPPLPPLPPSLPGLPSEALErrpDLRAAEAQLEAAEAEIGVARAaflpslSLSASYGYSSSDDLFS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2477 NSTALEEAMLQEQQRL---GLVWAALQGARTQLRDVRAKKDQ--LEAHIQAAQAMLAMDTDetskkiahakavaaeaQDT 2551
Cdd:COG1538 235 GGSDTWSVGLSLSLPLfdgGRNRARVRAAKAQLEQAEAQYEQtvLQALQEVEDALAALRAA----------------REQ 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768017173 2552 ATRVQSQLQAMQENVERWQGQYE-GLRGQdlgQAVLDAghsvstlEKTLpqLLAKLSILENRG-VHNASLALSASIGR 2627
Cdd:COG1538 299 LEALEEALEAAEEALELARARYRaGLASL---LDVLDA-------QREL--LQAQLNLIQARYdYLLALVQLYRALGG 364
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2285-2584 |
4.38e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.83 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2285 QHEAG---LMD-LREALNRAVDatREAQELNSRNQERLEEALQRKQELSRDnatlqatLHAARDTLASVFRLLHSLDQAK 2360
Cdd:COG4717 31 PNEAGkstLLAfIRAMLLERLE--KEADELFKPQGRKPELNLKELKELEEE-------LKEAEEKEEEYAELQEELEELE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2361 EELERLAASLDGARtpllQRMQtfspagsKLRLVEAAEAHAQQLGQLALNLSSIildvnQDRLtqraieasnaysrilqa 2440
Cdd:COG4717 102 EELEELEAELEELR----EELE-------KLEKLLQLLPLYQELEALEAELAEL-----PERL----------------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2441 vqaaedaagQALQQADHTWATVVRQgLVDRAQQLLANSTALEEAMLQEQQRlglVWAALQGARTQLRDVRAKKDQLEAHI 2520
Cdd:COG4717 149 ---------EELEERLEELRELEEE-LEELEAELAELQEELEELLEQLSLA---TEEELQDLAEELEELQQRLAELEEEL 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768017173 2521 QAAQamlamdtdetskkiahakavaaeaqdtatrvqsqlqamqENVERWQGQYEGLRGQDLGQA 2584
Cdd:COG4717 216 EEAQ---------------------------------------EELEELEEELEQLENELEAAA 240
|
|
| FlgL |
COG1344 |
Flagellin and related hook-associated protein FlgL [Cell motility]; |
2258-2455 |
4.76e-03 |
|
Flagellin and related hook-associated protein FlgL [Cell motility];
Pssm-ID: 440955 [Multi-domain] Cd Length: 245 Bit Score: 41.77 E-value: 4.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2258 LARVQEQLSSLWEENQA--LATQTrdrlaqheAGLMDLREALNRAVDATREAQELNSRNQ------ERLEEALQRKQELs 2329
Cdd:COG1344 23 LAKLQEQLSSGKRINSAsdDPAGA--------AIALRLRSQIRGLEQYQRNANDAISRLQtaegalGEITDILQRAREL- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2330 rdnaTLQA---TLHAA-RDTLASvfrllhSLDQAKEELERLAASLDGARTPLLQRMQTFSP---------AGSKLRLVEA 2396
Cdd:COG1344 94 ----AVQAangTLSDEdRAAIAA------ELEQLLDQLLSIANTTDFNGRYLFAGTATDTPpfqvdyqgdAGQRTAALGA 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768017173 2397 AEAHAQQLGQLALNLSSII--LDVNQDRLTQRAIEASNAYSRI-----------LQAVQAAEDAAGQALQQA 2455
Cdd:COG1344 164 LDAALDNVSSARAELGARQnrLESAINNLSDLSENLTAALSRLedadmaeaitrLTKLQTLLQAALAALAQA 235
|
|
| PspA |
COG1842 |
Phage shock protein A [Transcription, Signal transduction mechanisms]; |
2256-2374 |
5.13e-03 |
|
Phage shock protein A [Transcription, Signal transduction mechanisms];
Pssm-ID: 441447 [Multi-domain] Cd Length: 217 Bit Score: 41.35 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2256 RLLARVQEQLSSLweENQALA--TQTRDRLA--------QHEAGLMDLREALNRAVDATREAQELNSRNQERLEEALQRK 2325
Cdd:COG1842 58 RQLEELEAEAEKW--EEKARLalEKGREDLArealerkaELEAQAEALEAQLAQLEEQVEKLKEALRQLESKLEELKAKK 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 768017173 2326 QEL-SRDNA-----TLQATLHAARDTLAsvfrlLHSLDQAKEELERLAASLDGAR 2374
Cdd:COG1842 136 DTLkARAKAakaqeKVNEALSGIDSDDA-----TSALERMEEKIEEMEARAEAAA 185
|
|
| COG3899 |
COG3899 |
Predicted ATPase [General function prediction only]; |
2077-2639 |
5.51e-03 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443106 [Multi-domain] Cd Length: 1244 Bit Score: 42.92 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2077 DHCVVLLLDDLERA-GALLPAIHEQLRGINASSMAW---------ARLHRLNASIADLQSQLRS----PLGP--RHETAQ 2140
Cdd:COG3899 432 ERPLVLVLDDLHWAdPASLELLEFLLRRLRDLPLLLvgtyrpeevPPAHPLRLLLAELRRAGAGvtrlELGPlsREEVAA 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2141 QL-EVLEQQSTS-----------------LGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAvdRtLSELM 2202
Cdd:COG3899 512 LVaDLLGAAELPaelaellvertggnpffLEELLRALLEEGLLRFDGGGWRWDAALAALALPDTVVDLLAA--R-LDRLP 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2203 SQTGHLgLANASA---PSGEQLLRTL-----AEVERLLWEMRARDLgapQAAAEAELAAAQRLL-ARVQEQL-SSLWEEN 2272
Cdd:COG3899 589 PAARRV-LRLAAVlgrRFDLELLAAVlglseAELAAALEELVAAGL---LVPRGDAGGGRYRFRhDLVREAAyASLPPEE 664
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2273 ---------QALATQTRD-------RLAQH--EAGlmDLREALNRAVDATREAQELNSrnqerLEEA---LQRKQELSRD 2331
Cdd:COG3899 665 rralhrriaRALEARGPEpleerlfELAHHlnRAG--ERDRAARLLLRAARRALARGA-----YAEAlryLERALELLPP 737
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2332 NATLQATLhAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLLQRMQTFSPAGSKLRLVEAAE---AHAQQLGQLA 2408
Cdd:COG3899 738 DPEEEYRL-ALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLgdyEEAYEFGELA 816
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2409 LNLSSIILDVNQ---------------------DRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGL 2467
Cdd:COG3899 817 LALAERLGDRRLearalfnlgfilhwlgplreaLELLREALEAGLETGDAALALLALAAAAAAAAAAAALAAAAAAAARL 896
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2468 VDRAQQLLANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQAMLAMDTDETSKKIAHAKAVAAE 2547
Cdd:COG3899 897 LAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAALAAAA 976
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2548 AQDTATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGR 2627
Cdd:COG3899 977 AAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAAAAA 1056
|
650
....*....|..
gi 768017173 2628 VRELIAQARGAA 2639
Cdd:COG3899 1057 AAAAALAAAAAL 1068
|
|
| PEP_TPR_lipo |
TIGR02917 |
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ... |
2169-2538 |
5.88e-03 |
|
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.
Pssm-ID: 274350 [Multi-domain] Cd Length: 899 Bit Score: 42.76 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2169 QASQLLAGTEATLGH---AKTLLAAIRAVDRTLSELMSQtghLGLANASAPSGEQLLRTLAEVErllweMRARDLgapqa 2245
Cdd:TIGR02917 313 QAYQYLNQILKYAPNshqARRLLASIQLRLGRVDEAIAT---LSPALGLDPDDPAALSLLGEAY-----LALGDF----- 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2246 aaeaelAAAQRLLARVQEQLSslweENQALATQT-RDRLAQ--HEAGLMDLREALNRAVDATR----------EAQELNS 2312
Cdd:TIGR02917 380 ------EKAAEYLAKATELDP----ENAAARTQLgISKLSQgdPSEAIADLETAAQLDPELGRadlllilsylRSGQFDK 449
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2313 RN--QERLEE--------------ALQRKQELSRDNATLQATLHAARDTLASVFRLLH------SLDQAKEELERLAASL 2370
Cdd:TIGR02917 450 ALaaAKKLEKkqpdnaslhnllgaIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARidiqegNPDDAIQRFEKVLTID 529
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2371 DGARTPLLQ----RMQTFSPAGSKLRLVEAAEAHAQQLgQLALNLSSIILDVNQdrlTQRAIEASNAYSRILQAVQAAED 2446
Cdd:TIGR02917 530 PKNLRAILAlaglYLRTGNEEEAVAWLEKAAELNPQEI-EPALALAQYYLGKGQ---LKKALAILNEAADAAPDSPEAWL 605
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2447 AAGQA-LQQADHTWATVVRQGLVDRAQQllaNSTALEE-AMLQEQQRlglvwaALQGARTQLRdvRA---KKDQLEAHIQ 2521
Cdd:TIGR02917 606 MLGRAqLAAGDLNKAVSSFKKLLALQPD---SALALLLlADAYAVMK------NYAKAITSLK--RAlelKPDNTEAQIG 674
|
410
....*....|....*..
gi 768017173 2522 AAQAMLAMDTDETSKKI 2538
Cdd:TIGR02917 675 LAQLLLAAKRTESAKKI 691
|
|
| TolA |
COG3064 |
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
2259-2639 |
6.36e-03 |
|
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 42.33 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2259 ARVQEQLSSLweENQALATQTRDRLAQHEA------GLMDLREALNRAVDATREAQ----ELNSRNQERLEEA------L 2322
Cdd:COG3064 12 AAAQERLEQA--EAEKRAAAEAEQKAKEEAeeerlaELEAKRQAEEEAREAKAEAEqraaELAAEAAKKLAEAekaaaeA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2323 QRK--QELSRDNATLQATLHAARDTLASVFRllhSLDQAKEELERLA------ASLDGARTPLLQRMQTFSPAGSKLRLV 2394
Cdd:COG3064 90 EKKaaAEKAKAAKEAEAAAAAEKAAAAAEKE---KAEEAKRKAEEEAkrkaeeERKAAEAEAAAKAEAEAARAAAAAAAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2395 EAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYSRILQAVQAAEDAAGQALQQADHTWATVVRQGLVDRAQQL 2474
Cdd:COG3064 167 AAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAALG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2475 LANSTALEEAMLQEQQRLGLVWAALQGARTQLRDVRAKKDQLEAHIQAAQA--MLAMDTDETSKKIAHAKAVAAEAQDTA 2552
Cdd:COG3064 247 GAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLddSAALAAELLGAVAAEEAVLAAAAAAGA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 2553 TRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILENRGVHNASLALSASIGRVRELI 2632
Cdd:COG3064 327 LVVRGGGAASLEAALSLLAAGAAAAAAGAGALATGALGDALAAEAAGALLLGKLADVEEAAGAGILAAAGGGGLLGLRLD 406
|
....*..
gi 768017173 2633 AQARGAA 2639
Cdd:COG3064 407 LGAALLE 413
|
|
| TNFRSF16 |
cd13416 |
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ... |
1780-1946 |
8.45e-03 |
|
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.
Pssm-ID: 276921 [Multi-domain] Cd Length: 159 Bit Score: 39.98 E-value: 8.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1780 DRCLPGSGVCVDC-QHNTEgahCERCQAGF----VSSRDDPSAPCVSCPCPLSVPSNnfaegCVlRGGRTQClckpgyag 1854
Cdd:cd13416 16 EQCPPGEGVARPCgDNQTV---CEPCLDGVtfsdVVSHTEPCQPCTRCPGLMSMRAP-----CT-ATHDTVC-------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 1855 asceRCAPGFFGNPLvlGSSCQPCdcsgngdpnllfSDCDPLTGACRGClRHTTGPRCEICAPGFYG------NALLPgn 1928
Cdd:cd13416 79 ----ECAYGYYLDED--SGTCEPC------------TVCPPGQGVVQSC-GPNQDTVCEACPEGTYSdedsstDPCLP-- 137
|
170
....*....|....*...
gi 768017173 1929 CTRCDCTPCGTEACDPHS 1946
Cdd:cd13416 138 CTVCEDGEVELRECTPVS 155
|
|
| TSPN |
smart00210 |
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ... |
3469-3536 |
9.37e-03 |
|
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin
Pssm-ID: 214560 Cd Length: 184 Bit Score: 40.03 E-value: 9.37e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768017173 3469 TGLIFHLGQARTPPYLQLQVT--EKQVLLRADDGAGEFSTSVTRPSVLCDGQWHRLAVMKSGNVLRLEVD 3536
Cdd:smart00210 67 RGVLFAIYDAQNVRQFGLEVDgrANTLLLRYQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVD 136
|
|
| |
