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Conserved domains on  [gi|768004340|ref|XP_011526653|]
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harmonin-binding protein USHBP1 isoform X1 [Homo sapiens]

Protein Classification

MCC-bdg_PDZ domain-containing protein( domain architecture ID 10564712)

MCC-bdg_PDZ domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 299-348 3.36e-17

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


:

Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 75.05  E-value: 3.36e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 768004340  299 QLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQY 348
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEY 50
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 299-348 3.36e-17

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 75.05  E-value: 3.36e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 768004340  299 QLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQY 348
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEY 50
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 299-348 3.36e-17

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 75.05  E-value: 3.36e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 768004340  299 QLRGSIEKLKCFNRLLSAVLQGYKGRCEGLSMQLGQREAEATALHLALQY 348
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEY 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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