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Conserved domains on  [gi|768004176|ref|XP_011526624|]
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pre-B-cell leukemia transcription factor 4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBC super family cl04264
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
1-123 3.13e-69

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


The actual alignment was detected with superfamily member pfam03792:

Pssm-ID: 461052  Cd Length: 181  Bit Score: 212.24  E-value: 3.13e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004176    1 MLLAEGVCRPEKRGRGGAvaragtatpggcpNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRM 80
Cdd:pfam03792  72 MLLAEGVAGPEKSGSAEA-------------EDNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEF 138
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768004176   81 RPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLD 123
Cdd:pfam03792 139 RPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
125-186 2.29e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 2.29e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004176 125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNM 186
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
1-123 3.13e-69

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 212.24  E-value: 3.13e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004176    1 MLLAEGVCRPEKRGRGGAvaragtatpggcpNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRM 80
Cdd:pfam03792  72 MLLAEGVAGPEKSGSAEA-------------EDNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEF 138
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768004176   81 RPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLD 123
Cdd:pfam03792 139 RPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
125-186 2.29e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 2.29e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004176 125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNM 186
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
125-184 1.22e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 72.15  E-value: 1.22e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004176  125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKK 184
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
125-183 1.64e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.20  E-value: 1.64e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004176   125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYK 183
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
123-184 3.03e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.97  E-value: 3.03e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004176 123 DARRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKK 184
Cdd:COG5576   50 PPKSKRRRTTDEQLMVLEREF---EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
1-123 3.13e-69

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 212.24  E-value: 3.13e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004176    1 MLLAEGVCRPEKRGRGGAvaragtatpggcpNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRM 80
Cdd:pfam03792  72 MLLAEGVAGPEKSGSAEA-------------EDNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEF 138
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 768004176   81 RPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLD 123
Cdd:pfam03792 139 RPITPKEIERMVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
125-186 2.29e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 74.20  E-value: 2.29e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004176 125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNM 186
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
125-184 1.22e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 72.15  E-value: 1.22e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004176  125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKK 184
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
143-181 2.70e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 71.01  E-value: 2.70e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 768004176  143 FYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIR 181
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
125-183 1.64e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 69.20  E-value: 1.64e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004176   125 RRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYK 183
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
123-184 3.03e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.97  E-value: 3.03e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004176 123 DARRKRRNFSKQATEVLNEYFyshLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKK 184
Cdd:COG5576   50 PPKSKRRRTTDEQLMVLEREF---EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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