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Conserved domains on  [gi|768010838|ref|XP_011525571|]
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zinc finger protein 45 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 6.43e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.43e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010838     8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQ-STPDGLPQLEREEKLWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-542 7.47e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 7.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 169 CVKSFSWSSHLQINQRAHAGEKPYKC--EKCDNAFRRFSSLQAHQRVHSRAKSYTNDA------SYRSFSQRSH------ 234
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnSKASSSSLSSsssnsn 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 235 ---------LPHHQRVPT---GENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKK 302
Cdd:COG5048  119 dnnllsshsLPPSSRDPQlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 303 PYKCEECGKSFSWRSRLQAHERIHTgEKPYKCNACGKSFSYS----SHLNIHCRIHTGEKPYKCEECG--KGFSVGSHLQ 376
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESPRSSLptASSQSSSPNE 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 377 AHQISHTG-EKPYKCEECGKGFCRASNLLDHQRG--HTGE--KPYQCDA--CGKGFSRSSDFNIHFRVHTGEKPYKC--E 447
Cdd:COG5048  278 SDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklL 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 448 ECGKGFSQASNLLAHQR-----GHTGEKPY------KCGTCGKGFSRSSDLNVHCRihTGEKPYKCERCGKAFSQFSSLQ 516
Cdd:COG5048  358 NSSSKFSPLLNNEPPQSlqqykDLKNDKKSetlsnsCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLI 435

                        410       420
                 ....*....|....*....|....*.
gi 768010838 517 VHQRVHTGEKPYQCaeCGKGFSVGSQ 542
Cdd:COG5048  436 PHKKIHTNHAPLLC--SILKSFRRDL 459
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 496-607 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 496 GEKPYKCE--RCGKAFSQFSSLQVHQrvhtgekpyqcaecgkgfsvgsqLQAHQRCHTGEKPYQceecgkgfcrasnfLA 573
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-----------------------LHGHQNQKLHENPSP--------------EK 388

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768010838 574 HRGVHTGEKPYRCDVCGKRFRQRSYLQAHqRVHT 607
Cdd:COG5189  389 MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 1.32e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  626 YLQAHQRVHTGEKPYKCEECGKGFS 650
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
598-622 2.10e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  598 YLQAHQRVHTGERPYKCEECGKVFS 622
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 6.43e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.43e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010838     8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQ-STPDGLPQLEREEKLWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 6.70e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 6.70e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768010838    8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 2.23e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.23e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 768010838   8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVS 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-542 7.47e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 7.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 169 CVKSFSWSSHLQINQRAHAGEKPYKC--EKCDNAFRRFSSLQAHQRVHSRAKSYTNDA------SYRSFSQRSH------ 234
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnSKASSSSLSSsssnsn 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 235 ---------LPHHQRVPT---GENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKK 302
Cdd:COG5048  119 dnnllsshsLPPSSRDPQlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 303 PYKCEECGKSFSWRSRLQAHERIHTgEKPYKCNACGKSFSYS----SHLNIHCRIHTGEKPYKCEECG--KGFSVGSHLQ 376
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESPRSSLptASSQSSSPNE 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 377 AHQISHTG-EKPYKCEECGKGFCRASNLLDHQRG--HTGE--KPYQCDA--CGKGFSRSSDFNIHFRVHTGEKPYKC--E 447
Cdd:COG5048  278 SDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklL 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 448 ECGKGFSQASNLLAHQR-----GHTGEKPY------KCGTCGKGFSRSSDLNVHCRihTGEKPYKCERCGKAFSQFSSLQ 516
Cdd:COG5048  358 NSSSKFSPLLNNEPPQSlqqykDLKNDKKSetlsnsCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLI 435

                        410       420
                 ....*....|....*....|....*.
gi 768010838 517 VHQRVHTGEKPYQCaeCGKGFSVGSQ 542
Cdd:COG5048  436 PHKKIHTNHAPLLC--SILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 3.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010838  318 RLQAHERIHTGEKPYKCNACGKSFSY 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 496-607 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 496 GEKPYKCE--RCGKAFSQFSSLQVHQrvhtgekpyqcaecgkgfsvgsqLQAHQRCHTGEKPYQceecgkgfcrasnfLA 573
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-----------------------LHGHQNQKLHENPSP--------------EK 388

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768010838 574 HRGVHTGEKPYRCDVCGKRFRQRSYLQAHqRVHT 607
Cdd:COG5189  389 MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  626 YLQAHQRVHTGEKPYKCEECGKGFS 650
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
598-622 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  598 YLQAHQRVHTGERPYKCEECGKVFS 622
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 584-606 2.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|...
gi 768010838  584 YRCDVCGKRFRQRSYLQAHQRVH 606
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 6.43e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.22  E-value: 6.43e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010838     8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVGHQ-STPDGLPQLEREEKLWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 6.70e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 6.70e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768010838    8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 2.23e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.23e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 768010838   8 VTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNVVS 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-542 7.47e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 7.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 169 CVKSFSWSSHLQINQRAHAGEKPYKC--EKCDNAFRRFSSLQAHQRVHSRAKSYTNDA------SYRSFSQRSH------ 234
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnSKASSSSLSSsssnsn 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 235 ---------LPHHQRVPT---GENPYKYEECGRNVGKSSHCQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKK 302
Cdd:COG5048  119 dnnllsshsLPPSSRDPQlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 303 PYKCEECGKSFSWRSRLQAHERIHTgEKPYKCNACGKSFSYS----SHLNIHCRIHTGEKPYKCEECG--KGFSVGSHLQ 376
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqSPSSLSSSDSSSSASESPRSSLptASSQSSSPNE 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 377 AHQISHTG-EKPYKCEECGKGFCRASNLLDHQRG--HTGE--KPYQCDA--CGKGFSRSSDFNIHFRVHTGEKPYKC--E 447
Cdd:COG5048  278 SDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklL 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 448 ECGKGFSQASNLLAHQR-----GHTGEKPY------KCGTCGKGFSRSSDLNVHCRihTGEKPYKCERCGKAFSQFSSLQ 516
Cdd:COG5048  358 NSSSKFSPLLNNEPPQSlqqykDLKNDKKSetlsnsCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLI 435

                        410       420
                 ....*....|....*....|....*.
gi 768010838 517 VHQRVHTGEKPYQCaeCGKGFSVGSQ 542
Cdd:COG5048  436 PHKKIHTNHAPLLC--SILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-602 2.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 190 KPYKCEKCDNAFRRFSSLQAHQRVHSRAK----SYTNDASYRSF---SQRSHLPHHQRVPTGENPykyeECGRNVGKSSH 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKpsqcSYSGCDKSFSRpleLSRHLRTHHNNPSDLNSK----SLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 263 CQAPLIVHTGEKPYKCEECGVGFSQRSYLQVHLKVHTGKKPYKCEECGKSFswRSRLQAHERIHTGEKpykcNACGKSFS 342
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS--VNTPQSNSLHPPLPA----NSLSKDPS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 343 YSSHLNIHCRIHTGEKPYKCEECGKGFSVGSHLQAHQISHTGEKPYKCEECGKGF------CRASNLLDHQRGHTGEKPY 416
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 417 QCDACGKGFSRSSDFNIHFRVHTG-EKPYKCEECGKGFSQASNLLAHQRG--HTGE--KPYKCG--TCGKGFSRSSDLNV 489
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 490 HCRIHTGEKPYKC--ERCGKAFSQFSSLQVHQRVH-----TGEKPYQCA--ECGKGFSVGSQLQAHQRCHTGEKPYQCE- 559
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 768010838 560 -ECGKGFCRASNFLAHRGVHTGEKPYRCDVCgKRFRQRSYLQAH 602
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
301-662 3.21e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 3.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 301 KKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFSYSSHLN--IHCRIHTGEKpykceecgkgfsvgSHLQAH 378
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNP--------------SDLNSK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 379 QISHTGEKPYKCEECGKGFCRASNLLDHQRGHTGEKPYQ---------------CDAC-GKGFSRSSDFNIHFRV---HT 439
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnnpLPGNnSSSVNTPQSNSLHPPLpanSL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 440 GEKPYKC----------------EECGKGFSQAS--NLLAHQRGHTGEKPYKCGTCGKGFSRSSD----LNVHCRIHTGE 497
Cdd:COG5048  177 SKDPSSNlsllissnvstsipssSENSPLSSSYSipSSSSDQNLENSSSSLPLTTNSQLSPKSLLsqspSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 498 KPYKCERCG--KAFSQFSSLQVHQRVHTG-EKPYQCAECGKGFSVGSQLQAHQRC--HTGE--KPYQCEE--CGKGFCRA 568
Cdd:COG5048  257 ASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 569 SNFLAHRGVHTGEKPYRC--DVCGKRFRQ------RSYLQAHQRVHTGERPYKCEECGKVFSWSSYLQAHQRVHT---GE 637
Cdd:COG5048  337 DALKRHILLHTSISPAKEklLNSSSKFSPllnnepPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfRP 416

                        410       420
                 ....*....|....*....|....*
gi 768010838 638 KPYKCEECGKGFSWSSSLIIHQRVH 662
Cdd:COG5048  417 YNCKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-435 3.05e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 191 PYKCEKCDNAFRRFSSLQAHQRVHSRAKSYTN-DASYRSFSQRSHLPHHQRV--PTGENPYKYEECGRNVGKSSHCQAPL 267
Cdd:COG5048  195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSlPLTTNSQLSPKSLLSQSPSslSSSDSSSSASESPRSSLPTASSQSSS 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 268 IVHTGE-------KPYKCEECGVGFSQRSYLQVHL--KVHTGK--KPYKCEE--CGKSFSWRSRLQAHERIHTGEKPYKC 334
Cdd:COG5048  275 PNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 335 NACGKSFSYS--------SHLNIHCRIHTGEKPYKCEECGKGFSVGSHLQA-HQISHTGEKPY--KCEECGKGFCRASNL 403
Cdd:COG5048  355 KLLNSSSKFSpllnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSlHIITHLSFRPYncKNPPCSKSFNRHYNL 434

                        250       260       270
                 ....*....|....*....|....*....|..
gi 768010838 404 LDHQRGHTGEKPYQCDACGKGFSRSSDFNIHF 435
Cdd:COG5048  435 IPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
386-666 3.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 386 KPYKCEECGKGFCRASNLLDHQRGHTGEKPYQCDA--CGKGFSRSSDFNIHFRVHTGEKPYKCEECGKG--FSQASNLLA 461
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 462 HQRGHT--GEKPYKCGTCGKGFSRSSDLNVHCRIHTGEKPYKCERCGKAFSQFSSLQ-------------------VHQR 520
Cdd:COG5048  112 SSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 521 VHTGEKPYQCAECGKGFSVGSQLQAHQRCHTGEKPYQCEECGKGF------CRASNFLAHRGVHTGEKPYRCDVCGKRFR 594
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768010838 595 QRSYLQAHQRVHTGER-PYKCEECGKVFSWSSYLQAHQR--VHTGE--KPYKCEE--CGKGFSWSSSLIIHQRVHADDE 666
Cdd:COG5048  272 SSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 3.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010838  318 RLQAHERIHTGEKPYKCNACGKSFSY 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-314 5.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.81e-04
                          10        20
                  ....*....|....*....|....*
gi 768010838  290 YLQVHLKVHTGKKPYKCEECGKSFS 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-370 6.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.86e-04
                          10        20
                  ....*....|....*....|....*
gi 768010838  346 HLNIHCRIHTGEKPYKCEECGKGFS 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 7.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010838  486 DLNVHCRIHTGEKPYKCERCGKAFSQ 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 496-607 1.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 496 GEKPYKCE--RCGKAFSQFSSLQVHQrvhtgekpyqcaecgkgfsvgsqLQAHQRCHTGEKPYQceecgkgfcrasnfLA 573
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-----------------------LHGHQNQKLHENPSP--------------EK 388

                         90       100       110
                 ....*....|....*....|....*....|....
gi 768010838 574 HRGVHTGEKPYRCDVCGKRFRQRSYLQAHqRVHT 607
Cdd:COG5189  389 MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  626 YLQAHQRVHTGEKPYKCEECGKGFS 650
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 328-411 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 328 GEKPYKCN--ACGKSFSYSSHLNIHcRIHTGEKPYKCEECGKgfsvgshlQAHQISHTGEKPYKCEECGKGFcRASNLLD 405
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY-KNLNGLK 415


                 ....*.
gi 768010838 406 HQRGHT 411
Cdd:COG5189  416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
514-538 2.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  514 SLQVHQRVHTGEKPYQCAECGKGFS 538
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
598-622 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 768010838  598 YLQAHQRVHTGERPYKCEECGKVFS 622
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 610-662 2.50e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768010838 610 RPYkCEECGKVFSWSSYLQAHQRvhtgEKPYKCEECGKGFSWSSSLIIH-QRVH 662
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 584-606 2.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|...
gi 768010838  584 YRCDVCGKRFRQRSYLQAHQRVH 606
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-427 3.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010838  402 NLLDHQRGHTGEKPYQCDACGKGFSR 427
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-397 3.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.21e-03
                          10        20
                  ....*....|....*....|....
gi 768010838  374 HLQAHQISHTGEKPYKCEECGKGF 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-565 3.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.43e-03
                          10        20
                  ....*....|....*....|...
gi 768010838  543 LQAHQRCHTGEKPYQCEECGKGF 565
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-342 3.86e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 139 HYKDEGFSNQSSHlqvHRVHTGEKPYKGEHCVKSFSWSSHLQINQRAHAG-EKPYKCEKCDNAFRRFSSLQAHQR----- 212
Cdd:COG5048  239 SLLSQSPSSLSSS---DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvnhs 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010838 213 -----VHSRAKSYtndaSYRSFSQRSHLPHHQRVPTG--ENPYKYEECGRNVGKSSH--CQAPLIVHTGEKPYKCEE--- 280
Cdd:COG5048  316 geslkPFSCPYSL----CGKLFSRNDALKRHILLHTSisPAKEKLLNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtls 391

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768010838 281 --CGVGFSQRSYLQVHLKVHTGKKP--YKCEECGKSFSWRSRLQAHERIHTGEKPYKCNACGKSFS 342
Cdd:COG5048  392 nsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-455 4.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.02e-03
                          10        20
                  ....*....|....*....|..
gi 768010838  434 HFRVHTGEKPYKCEECGKGFSQ 455
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 444-466 8.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.03e-03
                          10        20
                  ....*....|....*....|...
gi 768010838  444 YKCEECGKGFSQASNLLAHQRGH 466
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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