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Conserved domains on  [gi|768008337|ref|XP_011525107|]
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NTPase KAP family P-loop domain-containing protein 1 isoform X3 [Homo sapiens]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KAP_NTPase super family cl46386
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
84-389 2.90e-11

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


The actual alignment was detected with superfamily member pfam07693:

Pssm-ID: 480726  Cd Length: 293  Bit Score: 64.71  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337   84 FLQPIITEvhLRRRNVQFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRRHYGALPFSVYsvLGNKPATRqdccqsewhcrr 163
Cdd:pfam07693  36 FLNLLEKE--LNEFNEEFIIVYFNPWSFSGQDDLDAELFSALADALEEEYSQLATKLL--IGKKLPAL------------ 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  164 rvclgllallaalglgvgllylslgghalghgspsgsllkvFGGAATTLSGSGLLMAVYSVGKhlfvsqrkkierlVSRE 243
Cdd:pfam07693 100 -----------------------------------------GIDAKIGLIFGVAIILALTGLV-------------VAIE 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  244 KFGSQLgfmcevKKEV-ELLTDFLCFLEIYQRRrlrVVLEVTGLDTCYPERVVGVLNAINTLLSDShaPFIFILVVDPSI 322
Cdd:pfam07693 126 EPMKKL------QTEIeELRSDIESTLKDLNKR---IVIIIDDLDRCEPEEIVLLLEAVRLLFDFP--NVVFILAADEEI 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768008337  323 LAACLESagNMKGTA-DNGYLFLNRTVTLPFSVPIMGRRTKLQFLhdaVQSRDDLLyREMTRKPWLPG 389
Cdd:pfam07693 195 LKKALEA--NYESGLeIDGQKYLEKIIQVPFTLPPLSLRQLKKFL---MLSFDNSE-EGTSSKDRDET 256
 
Name Accession Description Interval E-value
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
84-389 2.90e-11

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 64.71  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337   84 FLQPIITEvhLRRRNVQFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRRHYGALPFSVYsvLGNKPATRqdccqsewhcrr 163
Cdd:pfam07693  36 FLNLLEKE--LNEFNEEFIIVYFNPWSFSGQDDLDAELFSALADALEEEYSQLATKLL--IGKKLPAL------------ 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  164 rvclgllallaalglgvgllylslgghalghgspsgsllkvFGGAATTLSGSGLLMAVYSVGKhlfvsqrkkierlVSRE 243
Cdd:pfam07693 100 -----------------------------------------GIDAKIGLIFGVAIILALTGLV-------------VAIE 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  244 KFGSQLgfmcevKKEV-ELLTDFLCFLEIYQRRrlrVVLEVTGLDTCYPERVVGVLNAINTLLSDShaPFIFILVVDPSI 322
Cdd:pfam07693 126 EPMKKL------QTEIeELRSDIESTLKDLNKR---IVIIIDDLDRCEPEEIVLLLEAVRLLFDFP--NVVFILAADEEI 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768008337  323 LAACLESagNMKGTA-DNGYLFLNRTVTLPFSVPIMGRRTKLQFLhdaVQSRDDLLyREMTRKPWLPG 389
Cdd:pfam07693 195 LKKALEA--NYESGLeIDGQKYLEKIIQVPFTLPPLSLRQLKKFL---MLSFDNSE-EGTSSKDRDET 256
 
Name Accession Description Interval E-value
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
84-389 2.90e-11

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 64.71  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337   84 FLQPIITEvhLRRRNVQFLFIRFSAWQYAGTDKLWAGLVTTLCEGIRRHYGALPFSVYsvLGNKPATRqdccqsewhcrr 163
Cdd:pfam07693  36 FLNLLEKE--LNEFNEEFIIVYFNPWSFSGQDDLDAELFSALADALEEEYSQLATKLL--IGKKLPAL------------ 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  164 rvclgllallaalglgvgllylslgghalghgspsgsllkvFGGAATTLSGSGLLMAVYSVGKhlfvsqrkkierlVSRE 243
Cdd:pfam07693 100 -----------------------------------------GIDAKIGLIFGVAIILALTGLV-------------VAIE 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008337  244 KFGSQLgfmcevKKEV-ELLTDFLCFLEIYQRRrlrVVLEVTGLDTCYPERVVGVLNAINTLLSDShaPFIFILVVDPSI 322
Cdd:pfam07693 126 EPMKKL------QTEIeELRSDIESTLKDLNKR---IVIIIDDLDRCEPEEIVLLLEAVRLLFDFP--NVVFILAADEEI 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768008337  323 LAACLESagNMKGTA-DNGYLFLNRTVTLPFSVPIMGRRTKLQFLhdaVQSRDDLLyREMTRKPWLPG 389
Cdd:pfam07693 195 LKKALEA--NYESGLeIDGQKYLEKIIQVPFTLPPLSLRQLKKFL---MLSFDNSE-EGTSSKDRDET 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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