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Conserved domains on  [gi|767991560|ref|XP_011521935|]
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SET and MYND domain-containing protein 4 isoform X3 [Homo sapiens]

Protein Classification

SET and MYND domain-containing protein( domain architecture ID 15749133)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) and MYND (myeloid, Nervy, and DEAF-1) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
Gene Ontology:  GO:0032259|GO:0042054|GO:0046872|GO:1904047
PubMed:  16086857|25580534|25125178|34555372|24710145
SCOP:  4000530

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 404-602 3.06e-73

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


:

Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 235.66  E-value: 3.06e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 404 IVETPIPGCDIngKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPterivnssqlKAAVTPELCP 483
Cdd:cd10536   33 IVEKPYASVLL--PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYFLLW----------EASTELNGEE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 484 DVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPkGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRI 563
Cdd:cd10536  101 PESILGGLLLRHLQQLQCNAHAITELQTTSS-GSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPI 179

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767991560 564 RKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC 602
Cdd:cd10536  180 KKGEEITICYGPHFSRMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
296-335 1.49e-10

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 56.66  E-value: 1.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767991560  296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWElYHRTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWP-YHKKEC 39
NlpI super family cl34822
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
66-171 4.49e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG4785:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  66 DAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHsRPnteDMSLCHANRSAALFHLGQYETCLKDINRAQthgypeRLQPK- 144
Cdd:COG4785   71 DLAQLYYERGVAYDSLGDYDLAIADFDQALEL-DP---DLAEAYNNRGLAYLLLGDYDAALEDFDRAL------ELDPDy 140

                         90       100
                 ....*....|....*....|....*....
gi 767991560 145 --IMLRKAECLVALGRLQEAsqtISDLER 171
Cdd:COG4785  141 ayAYLNRGIALYYLGRYELA---IADLEK 166
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 239-269 2.50e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd20071:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 122  Bit Score: 38.51  E-value: 2.50e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767991560 239 VDPLKGRCLVATKDILPGELLVQEDAFVSVL 269
Cdd:cd20071    5 SEGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 404-602 3.06e-73

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 235.66  E-value: 3.06e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 404 IVETPIPGCDIngKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPterivnssqlKAAVTPELCP 483
Cdd:cd10536   33 IVEKPYASVLL--PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYFLLW----------EASTELNGEE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 484 DVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPkGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRI 563
Cdd:cd10536  101 PESILGGLLLRHLQQLQCNAHAITELQTTSS-GSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPI 179

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767991560 564 RKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC 602
Cdd:cd10536  180 KKGEEITICYGPHFSRMKRSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
296-335 1.49e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 56.66  E-value: 1.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767991560  296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWElYHRTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWP-YHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 528-574 7.84e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.98  E-value: 7.84e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767991560  528 ATGIFPVISLLNHSCSPNTSVSFI----STVATIRASQRIRKGQEILHCYG 574
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 528-578 2.18e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.03  E-value: 2.18e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767991560   528 ATGIFPVISLLNHSCSPNTSVSFI----STVATIRASQRIRKGQEILHCYGPHKS 578
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFVevngDDRIVIFALRDIKPGEELTIDYGSDYA 122
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
66-171 4.49e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  66 DAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHsRPnteDMSLCHANRSAALFHLGQYETCLKDINRAQthgypeRLQPK- 144
Cdd:COG4785   71 DLAQLYYERGVAYDSLGDYDLAIADFDQALEL-DP---DLAEAYNNRGLAYLLLGDYDAALEDFDRAL------ELDPDy 140

                         90       100
                 ....*....|....*....|....*....
gi 767991560 145 --IMLRKAECLVALGRLQEAsqtISDLER 171
Cdd:COG4785  141 ayAYLNRGIALYYLGRYELA---IADLEK 166
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
536-602 9.05e-05

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 42.64  E-value: 9.05e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991560 536 SLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYG--PHKSRmgvaerqqklrsqyfFDCACPAC 602
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNC 131
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 72-237 1.42e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560   72 REEGNKKFQEKDYTGAAVLYSKGVShSRPNtedmSLCHANRSAALFHLGQYETCLKDINRAQthgypeRLQP---KIMLR 148
Cdd:TIGR00990 131 KEKGNKAYRNKDFNKAIKLYSKAIE-CKPD----PVYYSNRAACHNALGDWEKVVEDTTAAL------ELDPdysKALNR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  149 KAECLVALGRLQEA-----SQTISDLERNFTATPALADVL-PQTLQRNLHRLKMKMQEKDSLT------ESFPAALA-KT 215
Cdd:TIGR00990 200 RANAYDGLGKYADAlldltASCIIDGFRNEQSAQAVERLLkKFAESKAKEILETKPENLPSVTfvgnylQSFRPKPRpAG 279

                         170       180
                  ....*....|....*....|..
gi 767991560  216 LEDAAlrEENEQLSNASSSIGL 237
Cdd:TIGR00990 280 LEDSN--ELDEETGNGQLQLGL 299
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 239-269 2.50e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 38.51  E-value: 2.50e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767991560 239 VDPLKGRCLVATKDILPGELLVQEDAFVSVL 269
Cdd:cd20071    5 SEGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 404-602 3.06e-73

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 235.66  E-value: 3.06e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 404 IVETPIPGCDIngKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPterivnssqlKAAVTPELCP 483
Cdd:cd10536   33 IVEKPYASVLL--PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCLQLSGYFLLW----------EASTELNGEE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 484 DVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPkGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRI 563
Cdd:cd10536  101 PESILGGLLLRHLQQLQCNAHAITELQTTSS-GSQVDTSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPI 179

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 767991560 564 RKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC 602
Cdd:cd10536  180 KKGEEITICYGPHFSRMKRSERQRLLKEQYFFDCSCEAC 218
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 512-602 2.69e-24

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 98.22  E-value: 2.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 512 TGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFIST-VATIRASQRIRKGQEILHCYGPHksRMGVAERQQKLR 590
Cdd:cd20071   33 SVPSNSFSLTDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDP--LLPRTERRRELL 110

                         90
                 ....*....|..
gi 767991560 591 SQYFFDCACPAC 602
Cdd:cd20071  111 EKYGFTCSCPRC 122
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 519-604 1.21e-20

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 90.56  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 519 VTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPhkSRMGVAERQQKLRSQYFFDCA 598
Cdd:cd19167  122 ISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYID--LLYPTEERRDQLRDQYFFLCQ 199


                 ....*.
gi 767991560 599 CPACQT 604
Cdd:cd19167  200 CADCQT 205
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 519-604 1.55e-17

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 81.64  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 519 VTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYgpHKSRMGVAERQQKLRSQYFFDCA 598
Cdd:cd19203  127 ICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISY--IDMLMPSEERRKQLRDQYCFECD 204


                 ....*.
gi 767991560 599 CPACQT 604
Cdd:cd19203  205 CFRCQD 210
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 516-604 2.29e-14

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 72.55  E-value: 2.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 516 GSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCY----GPhksrmgVAERQQKLRS 591
Cdd:cd19202  120 GFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYidllYP------TEDRNDRLRD 193

                         90
                 ....*....|...
gi 767991560 592 QYFFDCACPACQT 604
Cdd:cd19202  194 SYFFTCECQECTT 206
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 516-603 2.29e-13

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 69.75  E-value: 2.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 516 GSIVTDSRQVR-LATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCY--GPHKSrmgvAERQQKLRSQ 592
Cdd:cd10526  123 GFTLSDQRGLQaVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYidFLNTS----EDRKEQLKKQ 198

                         90
                 ....*....|.
gi 767991560 593 YFFDCACPACQ 603
Cdd:cd10526  199 YYFDCTCEHCT 209
zf-MYND pfam01753
MYND finger;
296-335 1.49e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 56.66  E-value: 1.49e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767991560  296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWElYHRTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWP-YHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 530-605 4.03e-10

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 61.17  E-value: 4.03e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991560 530 GIFPVISLLNHSCSPNTSVSFISTVAT--IRASQRIRKGQEILHCYGPHKSR-MGVAERQQKLRSQYFFDCACPACQTE 605
Cdd:cd10521  204 GLYLLQSCCNHSCVPNAEITFPENNFTlsLKALRDIQEGEEICISYLDECQReRSRHSRQKILRENYLFICNCPKCEAQ 282
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 528-574 7.84e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.98  E-value: 7.84e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767991560  528 ATGIFPVISLLNHSCSPNTSVSFI----STVATIRASQRIRKGQEILHCYG 574
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 528-578 2.18e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.03  E-value: 2.18e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767991560   528 ATGIFPVISLLNHSCSPNTSVSFI----STVATIRASQRIRKGQEILHCYGPHKS 578
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFVevngDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 533-576 9.17e-07

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 50.76  E-value: 9.17e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767991560 533 PVISLLNHSCSPNTSVSFISTVA--TIRASQRIRKGQEILHCYGPH 576
Cdd:cd19177  187 PFLDLLNHSPDVNVKAGFNKSGKcyEIRTGTDYKKGEEVFISYGPH 232
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
66-171 4.49e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  66 DAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHsRPnteDMSLCHANRSAALFHLGQYETCLKDINRAQthgypeRLQPK- 144
Cdd:COG4785   71 DLAQLYYERGVAYDSLGDYDLAIADFDQALEL-DP---DLAEAYNNRGLAYLLLGDYDAALEDFDRAL------ELDPDy 140

                         90       100
                 ....*....|....*....|....*....
gi 767991560 145 --IMLRKAECLVALGRLQEAsqtISDLER 171
Cdd:COG4785  141 ayAYLNRGIALYYLGRYELA---IADLEK 166
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
536-602 9.05e-05

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 42.64  E-value: 9.05e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767991560 536 SLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYG--PHKSRmgvaerqqklrsqyfFDCACPAC 602
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNC 131
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 72-237 1.42e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560   72 REEGNKKFQEKDYTGAAVLYSKGVShSRPNtedmSLCHANRSAALFHLGQYETCLKDINRAQthgypeRLQP---KIMLR 148
Cdd:TIGR00990 131 KEKGNKAYRNKDFNKAIKLYSKAIE-CKPD----PVYYSNRAACHNALGDWEKVVEDTTAAL------ELDPdysKALNR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  149 KAECLVALGRLQEA-----SQTISDLERNFTATPALADVL-PQTLQRNLHRLKMKMQEKDSLT------ESFPAALA-KT 215
Cdd:TIGR00990 200 RANAYDGLGKYADAlldltASCIIDGFRNEQSAQAVERLLkKFAESKAKEILETKPENLPSVTfvgnylQSFRPKPRpAG 279

                         170       180
                  ....*....|....*....|..
gi 767991560  216 LEDAAlrEENEQLSNASSSIGL 237
Cdd:TIGR00990 280 LEDSN--ELDEETGNGQLQLGL 299
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 79-178 1.86e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.52  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  79 FQEKDYTGAAVLYSKgVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQTHgYPE-RLQPKIMLRKAECLVALG 157
Cdd:COG1729    4 LKAGDYDEAIAAFKA-FLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKR-YPDsPKAPDALLKLGLSYLELG 81

                         90       100
                 ....*....|....*....|.
gi 767991560 158 RLQEASQTISDLERNFTATPA 178
Cdd:COG1729   82 DYDKARATLEELIKKYPDSEA 102
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 514-574 2.42e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 39.93  E-value: 2.42e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767991560 514 PKGSIVTDSRQVrlatgifpvisllNHSCSPNTSVSFIST----VATIRASQRIRKGQEILHCYG 574
Cdd:cd08161   21 PKGEVIGLARFI-------------NHSCEPNCEFEEVYVggkpRVFIVALRDIKAGEELTVDYG 72
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 533-576 2.43e-04

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 43.21  E-value: 2.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 767991560 533 PVISLLNHS-CSPNTSVSFISTVAT--IRASQRIRKGQEILHCYGPH 576
Cdd:cd10527  178 PLADMLNHSpDAPNVRYEYDEDEGSfvLVATRDIAAGEEVFISYGPK 224
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
75-231 1.44e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560  75 GNKKFQEKDYTGAAVLYSKGVSHsRPNTEDmslCHANRSAALFHLGQYETCLKDINRAQthgypeRLQPK---IMLRKAE 151
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALEL-DPDDAE---ALYNLGLALLELGRYDEAIEAYERAL------ELDPDdadALYNLGI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767991560 152 CLVALGRLQEAsqtISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNA 231
Cdd:COG0457  153 ALEKLGRYEEA---LELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 239-269 2.50e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 38.51  E-value: 2.50e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767991560 239 VDPLKGRCLVATKDILPGELLVQEDAFVSVL 269
Cdd:cd20071    5 SEGSKGRGLVATRDIEPGELILVEKPLVSVP 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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