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Conserved domains on  [gi|767987916|ref|XP_011521074|]
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intraflagellar transport protein 140 homolog isoform X9 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.65e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767987916  96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.65e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767987916  96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 1.67e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200   51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767987916 174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200  194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 5.77e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 5.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767987916   63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 7.04e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 7.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 767987916   102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.65e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767987916  96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
16-139 2.45e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  16 GSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKE 94
Cdd:COG2319  247 GSVRSVAFSPDGRLLA----SGSADGTVRLWdLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767987916  95 QHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 1.67e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200   51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767987916 174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200  194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
21-140 2.81e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  21 ISWHPVHPFLAVAyistTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMP 99
Cdd:COG2319  210 VAFSPDGKLLASG----SADGTVRLWdLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767987916 100 LTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQG 140
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 COG2319
WD40 repeat [General function prediction only];
63-133 5.93e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 5.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767987916  63 RVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 8.76e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 8.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  14 AAGSPSFISWHPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEV 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFspdgktlASGSADGTVRLWdLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767987916  86 TVFNKQD-KEQHTMPlTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  187 RLWDLATgKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
WD40 COG2319
WD40 repeat [General function prediction only];
35-139 2.64e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  35 ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSP 113
Cdd:COG2319   94 ASASADGTVRLWdLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                         90       100
                 ....*....|....*....|....*.
gi 767987916 114 SGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKLLR 198
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-121 2.79e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  19 SFISWHPVHPFLavayISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHT 97
Cdd:cd00200  181 NSVAFSPDGEKL----LSSSSDGTIKLWdLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         90       100
                 ....*....|....*....|....*
gi 767987916  98 MpLT-HTADITVLRWSPSGNCLLSG 121
Cdd:cd00200  256 T-LSgHTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 3.25e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987916  14 AAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767987916  94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 5.77e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 5.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767987916   63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 7.04e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 7.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 767987916   102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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