NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767987068|ref|XP_011520738|]
View 

protein CLEC16A isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
245-880 0e+00

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


:

Pssm-ID: 466083  Cd Length: 762  Bit Score: 1356.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  245 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLII 324
Cdd:pfam19439   1 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVNQEKGGERPKISPQVSLYLLSQVFLII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  325 HHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEK 404
Cdd:pfam19439  81 HYQPLVNSLADVILNGDLSVFSSQTEQDAQRSSAKSSIRCFIKPTETLERSLEINRHRGKKRTQKRPNYKNVGEEEEEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  405 GPtEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELAAstsVQEQNTTDEEKSAAATcSESTQWSRPFLDM 484
Cdd:pfam19439 161 GS-EGGQEDPDKAKGTEASSKGIKTSGEMEEIEMVVMEKCKLSELSA---VTEQNITDEEKSAAAT-RTHTQRSRPFLDM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  485 VYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAaEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLEL 564
Cdd:pfam19439 236 VYNALDCTEDDYHALFVLCLLYAMSHSKGINPDKLERIQLPVQTQ-ERNSYNHVLAERLIRIMNQAAQPDGKVRLATLEL 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  565 SCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGT 644
Cdd:pfam19439 315 SCLLLKQSVLSGSGCIIKDVHLACLEGAREESVHLLRHFYKGEEIFLDMFEDEYRSMTNKPLNVEYLMMDASILLPPTGT 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  645 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQ 724
Cdd:pfam19439 395 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLQGEPETQLPLTREEDLIKTDDVLDLNNSDLIACMVVTKDGGQAQ 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  725 RFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIA 804
Cdd:pfam19439 475 RFLAVDVYQMSLVEPDSKRLGWGVVKFAGLLQDMQVSGVEDDSRALNIIIHKPASNPHAKPFPILQATFIFADHIRCIIA 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987068  805 KQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVP 880
Cdd:pfam19439 555 KQRLAKGRIQARRMKMQRIAALLDLPVQPSTEVLGFGQTSSASSQHLPFRFYEQSRRGPSDPTVQRSVFASVDKVP 630
FPL pfam09758
Uncharacterized conserved protein; This entry represents an N-terminal region of approximately ...
51-198 6.74e-73

Uncharacterized conserved protein; This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.


:

Pssm-ID: 462884  Cd Length: 148  Bit Score: 236.68  E-value: 6.74e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068   51 IRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHK 130
Cdd:pfam09758   1 LRSIAELLIWGDKHDPEIFEYFCEKNILSTFVRILKNSTPSAVKIQLLQTISILIQNLKNKTSLYYLLSNNYINELISYP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767987068  131 FDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVY 198
Cdd:pfam09758  81 YDFNDEELLSYYISFLKTLSLRLNKDTVQFFFNQKYGSFPLLTEAIKFYNHKDSMVRTAVRNITLNIF 148
 
Name Accession Description Interval E-value
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
245-880 0e+00

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


Pssm-ID: 466083  Cd Length: 762  Bit Score: 1356.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  245 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLII 324
Cdd:pfam19439   1 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVNQEKGGERPKISPQVSLYLLSQVFLII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  325 HHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEK 404
Cdd:pfam19439  81 HYQPLVNSLADVILNGDLSVFSSQTEQDAQRSSAKSSIRCFIKPTETLERSLEINRHRGKKRTQKRPNYKNVGEEEEEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  405 GPtEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELAAstsVQEQNTTDEEKSAAATcSESTQWSRPFLDM 484
Cdd:pfam19439 161 GS-EGGQEDPDKAKGTEASSKGIKTSGEMEEIEMVVMEKCKLSELSA---VTEQNITDEEKSAAAT-RTHTQRSRPFLDM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  485 VYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAaEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLEL 564
Cdd:pfam19439 236 VYNALDCTEDDYHALFVLCLLYAMSHSKGINPDKLERIQLPVQTQ-ERNSYNHVLAERLIRIMNQAAQPDGKVRLATLEL 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  565 SCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGT 644
Cdd:pfam19439 315 SCLLLKQSVLSGSGCIIKDVHLACLEGAREESVHLLRHFYKGEEIFLDMFEDEYRSMTNKPLNVEYLMMDASILLPPTGT 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  645 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQ 724
Cdd:pfam19439 395 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLQGEPETQLPLTREEDLIKTDDVLDLNNSDLIACMVVTKDGGQAQ 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  725 RFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIA 804
Cdd:pfam19439 475 RFLAVDVYQMSLVEPDSKRLGWGVVKFAGLLQDMQVSGVEDDSRALNIIIHKPASNPHAKPFPILQATFIFADHIRCIIA 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987068  805 KQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVP 880
Cdd:pfam19439 555 KQRLAKGRIQARRMKMQRIAALLDLPVQPSTEVLGFGQTSSASSQHLPFRFYEQSRRGPSDPTVQRSVFASVDKVP 630
FPL pfam09758
Uncharacterized conserved protein; This entry represents an N-terminal region of approximately ...
51-198 6.74e-73

Uncharacterized conserved protein; This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.


Pssm-ID: 462884  Cd Length: 148  Bit Score: 236.68  E-value: 6.74e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068   51 IRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHK 130
Cdd:pfam09758   1 LRSIAELLIWGDKHDPEIFEYFCEKNILSTFVRILKNSTPSAVKIQLLQTISILIQNLKNKTSLYYLLSNNYINELISYP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767987068  131 FDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVY 198
Cdd:pfam09758  81 YDFNDEELLSYYISFLKTLSLRLNKDTVQFFFNQKYGSFPLLTEAIKFYNHKDSMVRTAVRNITLNIF 148
 
Name Accession Description Interval E-value
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
245-880 0e+00

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


Pssm-ID: 466083  Cd Length: 762  Bit Score: 1356.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  245 RNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQDKGGERPKISLPVSLYLLSQVFLII 324
Cdd:pfam19439   1 KNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLVNQEKGGERPKISPQVSLYLLSQVFLII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  325 HHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKPSIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEK 404
Cdd:pfam19439  81 HYQPLVNSLADVILNGDLSVFSSQTEQDAQRSSAKSSIRCFIKPTETLERSLEINRHRGKKRTQKRPNYKNVGEEEEEEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  405 GPtEDAQEDAEKAKGTEGGSKGIKTSGESEEIEMVIMERSKLSELAAstsVQEQNTTDEEKSAAATcSESTQWSRPFLDM 484
Cdd:pfam19439 161 GS-EGGQEDPDKAKGTEASSKGIKTSGEMEEIEMVVMEKCKLSELSA---VTEQNITDEEKSAAAT-RTHTQRSRPFLDM 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  485 VYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAaEKTTYNHPLAERLIRIMNNAAQPDGKIRLATLEL 564
Cdd:pfam19439 236 VYNALDCTEDDYHALFVLCLLYAMSHSKGINPDKLERIQLPVQTQ-ERNSYNHVLAERLIRIMNQAAQPDGKVRLATLEL 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  565 SCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLVRHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGT 644
Cdd:pfam19439 315 SCLLLKQSVLSGSGCIIKDVHLACLEGAREESVHLLRHFYKGEEIFLDMFEDEYRSMTNKPLNVEYLMMDASILLPPTGT 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  645 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDGGMVQ 724
Cdd:pfam19439 395 PLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLQGEPETQLPLTREEDLIKTDDVLDLNNSDLIACMVVTKDGGQAQ 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068  725 RFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASSPHSKPFPILQATFIFSDHIRCIIA 804
Cdd:pfam19439 475 RFLAVDVYQMSLVEPDSKRLGWGVVKFAGLLQDMQVSGVEDDSRALNIIIHKPASNPHAKPFPILQATFIFADHIRCIIA 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767987068  805 KQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGFGLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVP 880
Cdd:pfam19439 555 KQRLAKGRIQARRMKMQRIAALLDLPVQPSTEVLGFGQTSSASSQHLPFRFYEQSRRGPSDPTVQRSVFASVDKVP 630
FPL pfam09758
Uncharacterized conserved protein; This entry represents an N-terminal region of approximately ...
51-198 6.74e-73

Uncharacterized conserved protein; This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.


Pssm-ID: 462884  Cd Length: 148  Bit Score: 236.68  E-value: 6.74e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987068   51 IRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSNNYVNSIIVHK 130
Cdd:pfam09758   1 LRSIAELLIWGDKHDPEIFEYFCEKNILSTFVRILKNSTPSAVKIQLLQTISILIQNLKNKTSLYYLLSNNYINELISYP 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767987068  131 FDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVY 198
Cdd:pfam09758  81 YDFNDEELLSYYISFLKTLSLRLNKDTVQFFFNQKYGSFPLLTEAIKFYNHKDSMVRTAVRNITLNIF 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure