NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767986959|ref|XP_011520694|]
View 

UPF0764 protein C16orf89 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF4735 super family cl24457
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
 1-133 1.17e-63

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


The actual alignment was detected with superfamily member pfam15882:

Pssm-ID: 464922  Cd Length: 283  Bit Score: 198.73  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986959    1 MTKPGCSGYCLSHQLLFFLWARMRGCT---QGPLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFC 72
Cdd:pfam15882 128 MTQPGTSGYSLTHQLLYFLLGRMLGCTeklDKYLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVC 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767986959   73 GMGGFSDFYKLRWLEAILSWQKQQEGCFGEPDaedeelSKAIQYQQHFSRRVKRREKQFPD 133
Cdd:pfam15882 208 GMAGFSDFYKPDWLQMILSWQDPESGCFGKPA------ETEGESRSSPLSRVKRREKTLTD 262
 
Name Accession Description Interval E-value
DUF4735 pfam15882
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
 1-133 1.17e-63

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


Pssm-ID: 464922  Cd Length: 283  Bit Score: 198.73  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986959    1 MTKPGCSGYCLSHQLLFFLWARMRGCT---QGPLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFC 72
Cdd:pfam15882 128 MTQPGTSGYSLTHQLLYFLLGRMLGCTeklDKYLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVC 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767986959   73 GMGGFSDFYKLRWLEAILSWQKQQEGCFGEPDaedeelSKAIQYQQHFSRRVKRREKQFPD 133
Cdd:pfam15882 208 GMAGFSDFYKPDWLQMILSWQDPESGCFGKPA------ETEGESRSSPLSRVKRREKTLTD 262
 
Name Accession Description Interval E-value
DUF4735 pfam15882
Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. ...
 1-133 1.17e-63

Domain of unknown function (DUF4735); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 410 amino acids in length. There are two completely conserved C residues that may be functionally important. In mammals this protein family is thyroid-specific.


Pssm-ID: 464922  Cd Length: 283  Bit Score: 198.73  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986959    1 MTKPGCSGYCLSHQLLFFLWARMRGCT---QGPLQQS-----QDYINLFCANMMDLNRRAEAIGYAYPTRDIFMENIMFC 72
Cdd:pfam15882 128 MTQPGTSGYSLTHQLLYFLLGRMLGCTeklDKYLLASklggvQDLQEIFCSNIYKEMELLEKNGFPIQTQDLFLEQIVVC 207

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767986959   73 GMGGFSDFYKLRWLEAILSWQKQQEGCFGEPDaedeelSKAIQYQQHFSRRVKRREKQFPD 133
Cdd:pfam15882 208 GMAGFSDFYKPDWLQMILSWQDPESGCFGKPA------ETEGESRSSPLSRVKRREKTLTD 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH