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Conserved domains on  [gi|767985718|ref|XP_011520488|]
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dual oxidase maturation factor 1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DuoxA super family cl10894
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 10-184 3.27e-98

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


The actual alignment was detected with superfamily member pfam10204:

Pssm-ID: 462995  Cd Length: 277  Bit Score: 285.25  E-value: 3.27e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   10 FYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRGKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKA 89
Cdd:pfam10204   1 FYPSNRTPVTFDVLLIVIILVFLTLAVSFLLILPGIRGKERLFWFLRVTLSLFIGAVILAVNFGSEWEVGEVTTNTSYKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   90 FSSEWISADIGLQVGLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEKFTPRSP-CG 168
Cdd:pfam10204  81 FSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPYPILYVAEYFTLDSEgCR 160

                         170
                  ....*....|....*.
gi 767985718  169 LYRQYRLAGHYTSAML 184
Cdd:pfam10204 161 WGRQYRLAGYYASATL 176
 
Name Accession Description Interval E-value
DuoxA pfam10204
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 10-184 3.27e-98

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


Pssm-ID: 462995  Cd Length: 277  Bit Score: 285.25  E-value: 3.27e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   10 FYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRGKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKA 89
Cdd:pfam10204   1 FYPSNRTPVTFDVLLIVIILVFLTLAVSFLLILPGIRGKERLFWFLRVTLSLFIGAVILAVNFGSEWEVGEVTTNTSYKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   90 FSSEWISADIGLQVGLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEKFTPRSP-CG 168
Cdd:pfam10204  81 FSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPYPILYVAEYFTLDSEgCR 160

                         170
                  ....*....|....*.
gi 767985718  169 LYRQYRLAGHYTSAML 184
Cdd:pfam10204 161 WGRQYRLAGYYASATL 176
 
Name Accession Description Interval E-value
DuoxA pfam10204
Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential ...
 10-184 3.27e-98

Dual oxidase maturation factor; DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.


Pssm-ID: 462995  Cd Length: 277  Bit Score: 285.25  E-value: 3.27e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   10 FYAGPKPTFPMDTTLASIIMIFLTALATFIVILPGIRGKTRLFWLLRVVTSLFIGAAILAVNFSSEWSVGQVSTNTSYKA 89
Cdd:pfam10204   1 FYPSNRTPVTFDVLLIVIILVFLTLAVSFLLILPGIRGKERLFWFLRVTLSLFIGAVILAVNFGSEWEVGEVTTNTSYKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985718   90 FSSEWISADIGLQVGLGGVNITLTGTPVQQLNETINYNEEFTWRLGENYAEEYAKALEKGLPDPVLYLAEKFTPRSP-CG 168
Cdd:pfam10204  81 FSNEEINADIGLHIGLRGVNVTLKGTPVGQLNETIDYNERFSWRFAGDMNEEYRAALEKGLPYPILYVAEYFTLDSEgCR 160

                         170
                  ....*....|....*.
gi 767985718  169 LYRQYRLAGHYTSAML 184
Cdd:pfam10204 161 WGRQYRLAGYYASATL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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