NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767985152|ref|XP_011520273|]
View 

thrombospondin-1 isoform X2 [Homo sapiens]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10641979)

thrombospondin type-1 domain-containing protein similar to Plasmodium circumsporozoite protein that is an essential sporozoite protein required for development of malaria sporozoites in mosquitoes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 914-1111 4.86e-118

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.95  E-value: 4.86e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   914 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 993
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   994 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1073
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 767985152  1074 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1111
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.08e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


:

Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.08e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 767985152    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 1.54e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 80.32  E-value: 1.54e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767985152    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.09e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.85  E-value: 1.09e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985152   318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 5.67e-13

Thrombospondin type 1 domain;


:

Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 5.67e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767985152   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 788-824 2.15e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767985152   788 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 824
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 728-763 1.25e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767985152   728 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 763
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 861-894 2.00e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767985152   861 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 894
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 592-631 8.10e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 8.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767985152   592 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 631
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 914-1111 4.86e-118

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.95  E-value: 4.86e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   914 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 993
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   994 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1073
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 767985152  1074 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1111
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.08e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.08e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 767985152    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 1.54e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 80.32  E-value: 1.54e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767985152    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.09e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.85  E-value: 1.09e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985152   318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 9.50e-17

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 74.76  E-value: 9.50e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767985152   439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 8.54e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.85  E-value: 8.54e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767985152    318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 5.67e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 5.67e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767985152   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 1.55e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 1.55e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767985152    382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 788-824 2.15e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767985152   788 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 824
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 728-763 1.25e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767985152   728 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 763
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 861-894 2.00e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767985152   861 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 894
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 592-631 8.10e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 8.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767985152   592 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 631
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.49e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 767985152   200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 8.83e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110    54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                          90
                  ....*....|....*...
gi 767985152  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110   133 PGLPVSPGFVGCIRDLKV 150
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 914-1111 4.86e-118

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 361.95  E-value: 4.86e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   914 QNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTN 993
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   994 PTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1073
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 767985152  1074 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRD 1111
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 26-221 1.08e-49

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 174.08  E-value: 1.08e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152     26 GDNSVFDIFELTGAARKGSGRRlvkgpdPSSPAFRIEDanliPPVPDDKFQDLVDaVRAEKGFLLLASLRQMKKTRGTLL 105
Cdd:smart00210    3 DLLQVFDLPSLSFAIRQVVGPE------PGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152    106 ALERKDhSGQVFSVVSNGKAGTLDLS-LTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQ 184
Cdd:smart00210   72 AIYDAQ-NVRQFGLEVDGRANTLLLRyQGVDGKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 767985152    185 svfTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGT 221
Cdd:smart00210  151 ---PPIDTDGIEVRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 438-490 1.54e-18

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 80.32  E-value: 1.54e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767985152    438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.09e-17

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 77.85  E-value: 1.09e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985152   318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP_1 pfam00090
Thrombospondin type 1 domain;
439-489 9.50e-17

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 74.76  E-value: 9.50e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767985152   439 SHWSPWSSCSVTCGDGVITRIRLCNSPSPQmnGKPCEGEARETKACKKDAC 489
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIETQACKMDKC 49
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 8.54e-15

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 69.85  E-value: 8.54e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 767985152    318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTI-CKKVSCPIMP-CSNAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPPPdCPNPErvKPPGECCPRC 59
TSP_1 pfam00090
Thrombospondin type 1 domain;
383-428 5.67e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.36  E-value: 5.67e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767985152   383 SPWSEWTSCSTSCGNGIQQRGRSCDSL---NNRCEGSSVQTRTCHIQEC 428
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPfpgGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 382-429 1.55e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 1.55e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 767985152    382 WSPWSEWTSCSTSCGNGIQQRGRSCDSLNNR-----CEGSSVQTRTCHIQECD 429
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 788-824 2.15e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 53.52  E-value: 2.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767985152   788 DSDSDRIGDTCDNnqDIDEDGHQNNLDNCPYVPNANQ 824
Cdd:pfam02412    2 DSDSDGVGDACDN--DFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 439-489 2.53e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 53.82  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767985152   439 SHWSPWSSCSVTCGDGVITRIRLCNSPsPQMNGKPCeGEARETKACKKDAC 489
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 728-763 1.25e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767985152   728 ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQ 763
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 861-894 2.00e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 48.13  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 767985152   861 KDSDGDGRGDACKDDFDHDSVPDIDDICPENVDI 894
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANI 34
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 383-428 3.56e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.04  E-value: 3.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767985152   383 SPWSEWTSCSTSCGNGIQQR-----------GRSCDSLnnrcegssVQTRTCHIQEC 428
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPCPEL--------LERRPCNLPPC 52
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 592-631 8.10e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 8.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767985152   592 CTDGTHDCNKNAKCNYlghySDPMYRCECKPGYAGNGIIC 631
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 443-489 8.56e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.59  E-value: 8.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767985152   443 PWSSCSVTCGDGVITRIRLCNSPSPQ--MNGKPCEGEAR--ETKACKKDAC 489
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
318-385 2.10e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 37.93  E-value: 2.10e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767985152    318 CYHNGVQYRNNEEWtVDSCTECHCQNSVTICKKVSCPIMPCSNATVpDGECCPRCWPSDSADDGWSPW 385
Cdd:smart00215    1 CWNNGSYYPPGAKW-DDDCNRCTCLNGRVSCTKVWCGPKPCLLHNL-SGECPLGQGCVPSLSDCLSSP 66
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 324-372 4.95e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 40.83  E-value: 4.95e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767985152   324 QYRNNEEWTVDS-----CTECHCQNSVT---ICKKVS--CPIMPCSNATVPDGECCPRC 372
Cdd:pfam14828  177 QFHGAGALRVGPeacsdPSGCGCGNDENlerICANVLqrCPPPHCLSPLRPEGHCCDVC 235
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 124-217 5.49e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 5.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152   124 KAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYID-CEKMENAELDVPIQSVFTRDL---ASIARLRI 199
Cdd:pfam02210   26 VNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDgQTVVSSLPPGESLLLNLNGPLylgGLPPLLLL 105

                           90
                   ....*....|....*...
gi 767985152   200 AKGGVNDNFQGVLQNVRF 217
Cdd:pfam02210  106 PALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 124-217 8.83e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.17  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767985152  124 KAGTLDLSLTVQGKQHVVSVEEaLLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDL----ASIARLRI 199
Cdd:cd00110    54 EDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPlylgGLPEDLKS 132

                          90
                  ....*....|....*...
gi 767985152  200 AKGGVNDNFQGVLQNVRF 217
Cdd:cd00110   133 PGLPVSPGFVGCIRDLKV 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH