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Conserved domains on  [gi|767966264|ref|XP_011518557|]
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ribonuclease inhibitor isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 767966264 324 SF 325
Cdd:cd00116  318 SF 319
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767966264 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 767966264 324 SF 325
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767966264 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238  182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238  262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238  340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                        250       260
                 ....*....|....*....|
gi 767966264 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238  391 QGAEALIDALQT--NRLHTL 408
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 767966264    6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 767966264   397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 767966264   283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116    1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116  238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                 ..
gi 767966264 324 SF 325
Cdd:cd00116  318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767966264 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238  182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238  262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238  340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                        250       260
                 ....*....|....*....|
gi 767966264 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238  391 QGAEALIDALQT--NRLHTL 408
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 114-308 7.70e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 82.53  E-value: 7.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 114 TLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 194 LKdSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHpSSRLRTLWIWECGITAKGC 273
Cdd:COG5238  260 LK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767966264 274 GDLCRVLRAKESLKELSLAGNELGDEGARLLCETL 308
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 147-450 1.12e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 1.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 147 LQLEYCSLSaasCEPLASVLRAKPDFKELTV--SNNDINEAGVRVLCQGLKDSPcQLEALKLESCGVTSDNCRDLCGIVA 224
Cdd:COG5238  158 LLGLAARLG---LLAAISMAKALQNNSVETVylGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALK 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLL 304
Cdd:COG5238  234 GNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIAL 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264 305 CETLlEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQglgqpgsvlrvlwladcdvsd 384
Cdd:COG5238  313 AEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK--------------------- 370

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966264 385 sscsslaatLLANH-SLRELDLSNNCLGDAGILQLVESVRqpGCLLEQLVLYDIYWSEEMEDRLQAL 450
Cdd:COG5238  371 ---------YLEGNtTLRELNLGKNNIGKQGAEALIDALQ--TNRLHTLILDGNLIGAEAQQRLEQL 426
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-195 3.45e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.89  E-value: 3.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   5 IQSLDIQCEELSDARWAELLPLLQ-QCQVVRLDDCG--LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238  238 LTTLDLSNNQIGDEGVIALAEALKnNTTVETLYLSGnqIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEP 161
Cdd:COG5238  318 GNK-TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEA 395

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767966264 162 LASVLRaKPDFKELTVSNNDINEAGVRVLCQGLK 195
Cdd:COG5238  396 LIDALQ-TNRLHTLILDGNLIGAEAQQRLEQLLE 428
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 767966264    6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-182 6.10e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 6.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264   4 DIQSLDIQCEELSDarWAELLPLLQQCQVVRLDDCGLTearckDISSALRVNPALAELNLRSNELGDVGVHcvLQGLQtp 83
Cdd:COG4886  114 NLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLT-- 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966264  84 scKIQKLSLQNCCLTgagcgVLSSTLRTLPTLQELHLSDNLLGDAGLQLlceglldPQC-RLEKLQLEYCSLSAascepl 162
Cdd:COG4886  183 --NLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTDLPEPL-------ANLtNLETLDLSNNQLTD------ 242

                        170       180
                 ....*....|....*....|
gi 767966264 163 ASVLRAKPDFKELTVSNNDI 182
Cdd:COG4886  243 LPELGNLTNLEELDLSNNQL 262
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 767966264   397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 767966264   283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
112-139 1.02e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|....*...
gi 767966264   112 LPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
340-367 3.92e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 3.92e-03
                           10        20
                   ....*....|....*....|....*...
gi 767966264   340 NRFLLELQISNNRLEDAGVRELCQGLGQ 367
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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