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Conserved domains on  [gi|767966094|ref|XP_011518490|]
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cadherin-related family member 5 isoform X2 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 5.73e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 5.73e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966094 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 4.57e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966094 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
PRK13700 super family cl32925
conjugal transfer protein TraD; Provisional
 438-509 3.03e-04

conjugal transfer protein TraD; Provisional


The actual alignment was detected with superfamily member PRK13700:

Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 44.18  E-value: 3.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966094 438 VTSGTATTVIEIQVSEQEPPSTAQTPEPgtSQPMPPSMG-TSTSHQPATPGGGT----AQTPEAGTSQPMPPGMGTS 509
Cdd:PRK13700 610 VASGEDVTQAEQPQQPQQPQQPQQPQQP--QQPVSPVINdKKSDAGVNVPAGGIeqelKMKPEEEMEQQLPPGISES 684
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-541 1.33e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  308 NLTVARSVPSPMTfllLVKGQQAdlARYSVTQVTVEAVAAAGSpprfpqrLYRGTVARGAGAGVVVKDAAAPSQPLRIQA 387
Cdd:pfam17823  59 NFCAATAAPAPVT---LTKGTSA--AHLNSTEVTAEHTPHGTD-------LSEPATREGAADGAASRALAAAASSSPSSA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  388 QdpefSDLNSAITyRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN----TVTSGTATTVIEIQVSEQEPPSTAQTP 463
Cdd:pfam17823 127 A----QSLPAAIA-ALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAaspaPRTAASSTTAASSTTAASSAPTTAASS 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  464 EPGTSQPMPPSMGTSTSHQPATPGGGTAQ----TPEAGT-----SQPMPPGMGTSTSH-QPTTPGGGTAQTPEPGTSQPM 533
Cdd:pfam17823 202 APATLTPARGISTAATATGHPAAGTALAAvgnsSPAAGTvtaavGTVTPAALATLAAAaGTVASAAGTINMGDPHARRLS 281


                  ....*...
gi 767966094  534 PlSKSTPS 541
Cdd:pfam17823 282 P-AKHMPS 288
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 5.73e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 5.73e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966094 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 276-314 2.90e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767966094   276 AEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARS 314
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP 40
Cadherin pfam00028
Cadherin domain;
253-343 4.19e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  253 YHGAVPTGhILPSPLVLRpgpIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA 330
Cdd:pfam00028   1 YSASVPEN-APVGTEVLT---VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEATDS 76

                          90
                  ....*....|....
gi 767966094  331 DL-ARYSVTQVTVE 343
Cdd:pfam00028  77 GGpPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 4.57e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966094 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-122 3.25e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 3.25e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767966094    71 FRI--QGNQLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAP 122
Cdd:smart00112  26 FSIdpETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 438-509 3.03e-04

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 44.18  E-value: 3.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966094 438 VTSGTATTVIEIQVSEQEPPSTAQTPEPgtSQPMPPSMG-TSTSHQPATPGGGT----AQTPEAGTSQPMPPGMGTS 509
Cdd:PRK13700 610 VASGEDVTQAEQPQQPQQPQQPQQPQQP--QQPVSPVINdKKSDAGVNVPAGGIeqelKMKPEEEMEQQLPPGISES 684
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 418-543 9.12e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  418 TTTTLAQAgafyAEVEAHNTVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAG 497
Cdd:pfam05109 444 TTTGLPSS----THVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPN 519

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966094  498 TSQPMP-----------PGMGTSTSHQPTTPGGGTAQTPEPGTSQPMP------LSKSTPSSG 543
Cdd:pfam05109 520 ATSPTPavttptpnatsPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPnatiptLGKTSPTSA 582
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-541 1.33e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  308 NLTVARSVPSPMTfllLVKGQQAdlARYSVTQVTVEAVAAAGSpprfpqrLYRGTVARGAGAGVVVKDAAAPSQPLRIQA 387
Cdd:pfam17823  59 NFCAATAAPAPVT---LTKGTSA--AHLNSTEVTAEHTPHGTD-------LSEPATREGAADGAASRALAAAASSSPSSA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  388 QdpefSDLNSAITyRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN----TVTSGTATTVIEIQVSEQEPPSTAQTP 463
Cdd:pfam17823 127 A----QSLPAAIA-ALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAaspaPRTAASSTTAASSTTAASSAPTTAASS 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  464 EPGTSQPMPPSMGTSTSHQPATPGGGTAQ----TPEAGT-----SQPMPPGMGTSTSH-QPTTPGGGTAQTPEPGTSQPM 533
Cdd:pfam17823 202 APATLTPARGISTAATATGHPAAGTALAAvgnsSPAAGTvtaavGTVTPAALATLAAAaGTVASAAGTINMGDPHARRLS 281


                  ....*...
gi 767966094  534 PlSKSTPS 541
Cdd:pfam17823 282 P-AKHMPS 288
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-343 5.73e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 5.73e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966094 274 IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP--SPMTFLLLVKGQ-QADLARYSVTQVTVE 343
Cdd:cd11304   19 VSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATdGGGPPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 276-314 2.90e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 45.80  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767966094   276 AEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARS 314
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP 40
Cadherin pfam00028
Cadherin domain;
253-343 4.19e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.75  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  253 YHGAVPTGhILPSPLVLRpgpIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA 330
Cdd:pfam00028   1 YSASVPEN-APVGTEVLT---VTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdrESIGEYELTVEATDS 76

                          90
                  ....*....|....
gi 767966094  331 DL-ARYSVTQVTVE 343
Cdd:pfam00028  77 GGpPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 37-120 4.57e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 4.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  37 FEVEENTNVTEPLVDIHV-----PEGQEVT--LGALSTPFAFRIQGN--QLFLNVTPDYEEKSLLEAQLLCQSGGT--LV 105
Cdd:cd11304    4 VSVPENAPPGTVVLTVSAtdpdsGENGEVTysIVSGNEDGLFSIDPStgEITTAKPLDREEQSSYTLTVTATDGGGppLS 83

                         90
                 ....*....|....*
gi 767966094 106 TQLRVFVSVLDVNDN 120
Cdd:cd11304   84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-122 3.25e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 3.25e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767966094    71 FRI--QGNQLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAP 122
Cdd:smart00112  26 FSIdpETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 438-509 3.03e-04

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 44.18  E-value: 3.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767966094 438 VTSGTATTVIEIQVSEQEPPSTAQTPEPgtSQPMPPSMG-TSTSHQPATPGGGT----AQTPEAGTSQPMPPGMGTS 509
Cdd:PRK13700 610 VASGEDVTQAEQPQQPQQPQQPQQPQQP--QQPVSPVINdKKSDAGVNVPAGGIeqelKMKPEEEMEQQLPPGISES 684
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 418-543 9.12e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  418 TTTTLAQAgafyAEVEAHNTVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAG 497
Cdd:pfam05109 444 TTTGLPSS----THVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPN 519

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767966094  498 TSQPMP-----------PGMGTSTSHQPTTPGGGTAQTPEPGTSQPMP------LSKSTPSSG 543
Cdd:pfam05109 520 ATSPTPavttptpnatsPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPnatiptLGKTSPTSA 582
PHA03378 PHA03378
EBNA-3B; Provisional
 454-541 1.23e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 454 QEPPSTAQTPePGTSQPMPPSMGTSTSHQPATPGGGTAQTPEA---------GTSQPMPPGMGTSTSHQPTTPGGGTAQT 524
Cdd:PHA03378 688 QWAPGTMQPP-PRAPTPMRPPAAPPGRAQRPAAATGRARPPAAapgrarppaAAPGRARPPAAAPGRARPPAAAPGRARP 766

                         90
                 ....*....|....*....
gi 767966094 525 PE--PGTSQPMPLSKSTPS 541
Cdd:PHA03378 767 PAaaPGAPTPQPPPQAPPA 785
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 308-541 1.33e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  308 NLTVARSVPSPMTfllLVKGQQAdlARYSVTQVTVEAVAAAGSpprfpqrLYRGTVARGAGAGVVVKDAAAPSQPLRIQA 387
Cdd:pfam17823  59 NFCAATAAPAPVT---LTKGTSA--AHLNSTEVTAEHTPHGTD-------LSEPATREGAADGAASRALAAAASSSPSSA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  388 QdpefSDLNSAITyRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN----TVTSGTATTVIEIQVSEQEPPSTAQTP 463
Cdd:pfam17823 127 A----QSLPAAIA-ALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAaspaPRTAASSTTAASSTTAASSAPTTAASS 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  464 EPGTSQPMPPSMGTSTSHQPATPGGGTAQ----TPEAGT-----SQPMPPGMGTSTSH-QPTTPGGGTAQTPEPGTSQPM 533
Cdd:pfam17823 202 APATLTPARGISTAATATGHPAAGTALAAvgnsSPAAGTvtaavGTVTPAALATLAAAaGTVASAAGTINMGDPHARRLS 281


                  ....*...
gi 767966094  534 PlSKSTPS 541
Cdd:pfam17823 282 P-AKHMPS 288
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
454-543 1.95e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.68  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 454 QEPPSTAQTPEPGTSQPM---PPSMGTSTSHQP------ATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQT 524
Cdd:PRK14971 370 SGGRGPKQHIKPVFTQPAaapQPSAAAAASPSPsqssaaAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRP 449

                         90
                 ....*....|....*....
gi 767966094 525 PEPGTSQPMPLSKsTPSSG 543
Cdd:PRK14971 450 AQFKEEKKIPVSK-VSSLG 467
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 433-541 2.00e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  433 EAHNTVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTpeagtsqpmppGMGTSTSH 512
Cdd:pfam05109 708 QASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTT-----------GHGARTST 776

                          90       100
                  ....*....|....*....|....*....
gi 767966094  513 QPTTPGGGTAQTPEPGTSQPMPLSKSTPS 541
Cdd:pfam05109 777 EPTTDYGGDSTTPRTRYNATTYLPPSTSS 805
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 423-540 3.31e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 423 AQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPM 502
Cdd:PRK07764 395 AAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAP 474

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767966094 503 PPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTP 540
Cdd:PRK07764 475 EPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
motB PRK12799
flagellar motor protein MotB; Reviewed
 437-542 3.31e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.47  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 437 TVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPAT------PGGGTAQTPEAGTSQPMPPGMGTST 510
Cdd:PRK12799 304 VTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGvlpsdvTLPGTVALPAAEPVNMQPQPMSTTE 383

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767966094 511 SHQPTTpGGGTAQTPEPGTSQP-MPLSKSTPSS 542
Cdd:PRK12799 384 TQQSST-GNITSTANGPTTSLPaAPASNIPVSP 415
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 426-549 4.38e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 426 GAFYAEVEAhntVTSGTATTVIEIQVSEQEPPSTAQTPEPGTSQPMPPSMGTSTSHQPATPggGTAQTPEAGTSQPMPPG 505
Cdd:PRK07764 372 RGLLARLER---LERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAP--QPAPAPAPAPAPPSPAG 446

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767966094 506 MGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSED 549
Cdd:PRK07764 447 NAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAP 490
PHA03378 PHA03378
EBNA-3B; Provisional
 454-546 4.39e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 4.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094 454 QEPPSTAQTPEPGTSqPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPgtsQPM 533
Cdd:PHA03378 708 AAPPGRAQRPAAATG-RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPP---QAP 783

                         90
                 ....*....|...
gi 767966094 534 PLSKSTPSSGGGP 546
Cdd:PHA03378 784 PAPQQRPRGAPTP 796
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 449-534 4.91e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  449 IQVSEQEPPSTAQTPEP-------GTSQPMPPSMGTSTSHQP-ATPGGGTAQTPEAGTSQ--PMP----PGMGTSTSHQP 514
Cdd:pfam03154 249 LQPMTQPPPPSQVSPQPlpqpslhGQMPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQvpPGPspaaPGQSQQRIHTP 328

                          90       100
                  ....*....|....*....|
gi 767966094  515 ttPGGGTAQTPEPGTSQPMP 534
Cdd:pfam03154 329 --PSQSQLQSQQPPREQPLP 346
PHA03247 PHA03247
large tegument protein UL36; Provisional
 453-543 5.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767966094  453 EQEPPSTAQTPEPGTSQPMPPSmgtSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQP----TTPGGGTA---QTP 525
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQPQPPP---PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgaLVPGRVAVprfRVP 2980

                          90
                  ....*....|....*...
gi 767966094  526 EPGTSQPMPLSKSTPSSG 543
Cdd:PHA03247 2981 QPAPSREAPASSTPPLTG 2998
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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