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Conserved domains on  [gi|767965860|ref|XP_011518388|]
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protein inscuteable homolog isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Insc_C pfam19427
Protein inscuteable C-terminal; This entry represents the C-terminal region of protein ...
80-491 0e+00

Protein inscuteable C-terminal; This entry represents the C-terminal region of protein Inscuteable (Insc) containing four putative armadillo repeats and the conserved extreme C-terminal tetrapeptide Glu-Ser-Phe-Val which is in agreement with the class I PDZ-binding motif X-Ser/Thr-X-/ (X and /are unspecified and hydrophobic residues, respectively). Insc functions as an adaptor protein that binds simultaneously with Partner of Insc (Pins, consisting of alpha subunit (Ga) of heterotrimeric G proteins and its guanine nucleotide dissociation inhibitor) and Par3 (PDZ-containing proteins) to regulate their apical localization in neuroblasts, which is required for the correct execution of the asymmetric division.


:

Pssm-ID: 466076  Cd Length: 394  Bit Score: 584.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860   80 RGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGeiekllmekcselsavterclqvene 159
Cdd:pfam19427   1 RAWIISTELTKIFQKLEKNRWQRVHSTAVRLNCHVRSMISEYSSFARNSSEEMQ-------------------------- 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  160 hvlksmkacvsetlsmlgqhfgqllelaltrevQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALF 239
Cdd:pfam19427  55 ---------------------------------QILVRQIESSDNIYTIESAISSLFSLTQEGAQLCSIIAKEGGVVALF 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  240 KVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFL 319
Cdd:pfam19427 102 KICRQDCFRCLYPHALRTLASICCVEEGINQLEKVDGILCLADILTDETHSEATRAEAAAVVAQITSPHLPFTQHLSSFL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  320 ESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMS 399
Cdd:pfam19427 182 ENMEDIVTALIKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAMKILLEACTDKQRVDTPYSRDQVVTILANMS 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  400 VLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSER 479
Cdd:pfam19427 262 VLEQCASDIIQENGIELLMEMLSEKPSSGSPAEVAACERVQQKAAVTLARLSRDPDVARTAIKLNCIPRLIELCRSPAER 341
                         410
                  ....*....|..
gi 767965860  480 NSSDAVLVACLA 491
Cdd:pfam19427 342 NNSDSVLVACLA 353
INSC_LBD pfam16748
Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable ...
23-69 1.28e-24

Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable homolog protein. It interacts with the TPR motifs of G-protein-signaling modulator 2 (GPSM2) (LGN) and stabilizes LGN.


:

Pssm-ID: 465257  Cd Length: 47  Bit Score: 96.14  E-value: 1.28e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767965860   23 MQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPG 69
Cdd:pfam16748   1 IQVDSVQRWMEDLRLMTEVECMCVLQSKPISVEEDAQGELIVSSGHG 47
 
Name Accession Description Interval E-value
Insc_C pfam19427
Protein inscuteable C-terminal; This entry represents the C-terminal region of protein ...
80-491 0e+00

Protein inscuteable C-terminal; This entry represents the C-terminal region of protein Inscuteable (Insc) containing four putative armadillo repeats and the conserved extreme C-terminal tetrapeptide Glu-Ser-Phe-Val which is in agreement with the class I PDZ-binding motif X-Ser/Thr-X-/ (X and /are unspecified and hydrophobic residues, respectively). Insc functions as an adaptor protein that binds simultaneously with Partner of Insc (Pins, consisting of alpha subunit (Ga) of heterotrimeric G proteins and its guanine nucleotide dissociation inhibitor) and Par3 (PDZ-containing proteins) to regulate their apical localization in neuroblasts, which is required for the correct execution of the asymmetric division.


Pssm-ID: 466076  Cd Length: 394  Bit Score: 584.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860   80 RGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGeiekllmekcselsavterclqvene 159
Cdd:pfam19427   1 RAWIISTELTKIFQKLEKNRWQRVHSTAVRLNCHVRSMISEYSSFARNSSEEMQ-------------------------- 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  160 hvlksmkacvsetlsmlgqhfgqllelaltrevQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALF 239
Cdd:pfam19427  55 ---------------------------------QILVRQIESSDNIYTIESAISSLFSLTQEGAQLCSIIAKEGGVVALF 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  240 KVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFL 319
Cdd:pfam19427 102 KICRQDCFRCLYPHALRTLASICCVEEGINQLEKVDGILCLADILTDETHSEATRAEAAAVVAQITSPHLPFTQHLSSFL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  320 ESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMS 399
Cdd:pfam19427 182 ENMEDIVTALIKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAMKILLEACTDKQRVDTPYSRDQVVTILANMS 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  400 VLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSER 479
Cdd:pfam19427 262 VLEQCASDIIQENGIELLMEMLSEKPSSGSPAEVAACERVQQKAAVTLARLSRDPDVARTAIKLNCIPRLIELCRSPAER 341
                         410
                  ....*....|..
gi 767965860  480 NSSDAVLVACLA 491
Cdd:pfam19427 342 NNSDSVLVACLA 353
INSC_LBD cd21966
LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) ...
24-332 3.07e-96

LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) functions as an adapter protein linking the Par polarity complex (composed of Par3, Par6 and protein kinase C iota) to the Gpsm1/Gpsm2 complex, and is involved in cell polarity and spindle orientation during mitosis. Par3 interacts with INSC which binds directly to Pins (partner of Insc, homolog of vertebrate LGN/Gpsm2 and AGS3/Gpsm1). Pins then associates with the heterotrimeric G proteins and NuMA, which interacts directly with the cell spindle to control the orientation of the spindle and the division plane of mitotic cells. INSC may regulate cell proliferation and differentiation in the developing nervous system, may play a role in the asymmetric division of fibroblasts, and may also participate in the process of stratification of the squamous epithelium. This model corresponds to the Leu-Gly-Asn Repeat-Enriched Protein (LGN)-binding domain (LBD) of INSC. It interacts with the tetratricopeptide repeat (TPR) motifs of LGN, also called G-protein-signaling modulator 2 (Gpsm2).


Pssm-ID: 439320 [Multi-domain]  Cd Length: 300  Bit Score: 293.78  E-value: 3.07e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  24 QVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGgpgPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARV 103
Cdd:cd21966    1 DSDSVQQWLSELRLMTEPECMTTLQSKSIAGEEDQKVKLLVSS---ATDSIRKLQQRAHIISAEFDKLYRKLEKGRWKQV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860 104 HSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQvenehvLKSMKACVSETLSMLGQHFGQL 183
Cdd:cd21966   78 HPLIQSLTGHIRSLLQEYNATLPELPPELQQYEQRLLEICEELRTAAERSLG------SKPNLEELLKLLTTLGQSFSKL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860 184 LELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICC 263
Cdd:cd21966  152 VDLLLLKELQILVDSLEEPTSELSLRAALSALTSLGLEGPHLCRLIAKEGGVRALLIVCRDCKSSSVRALALRALATVCC 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767965860 264 VEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKL 332
Cdd:cd21966  232 VPEAIRQFEKAGGIEILSDILTDESRSEPERSEAAGVLAQITSPWIDDNHHLSGLIEHMEDLVKALTRL 300
INSC_LBD pfam16748
Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable ...
23-69 1.28e-24

Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable homolog protein. It interacts with the TPR motifs of G-protein-signaling modulator 2 (GPSM2) (LGN) and stabilizes LGN.


Pssm-ID: 465257  Cd Length: 47  Bit Score: 96.14  E-value: 1.28e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767965860   23 MQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPG 69
Cdd:pfam16748   1 IQVDSVQRWMEDLRLMTEVECMCVLQSKPISVEEDAQGELIVSSGHG 47
 
Name Accession Description Interval E-value
Insc_C pfam19427
Protein inscuteable C-terminal; This entry represents the C-terminal region of protein ...
80-491 0e+00

Protein inscuteable C-terminal; This entry represents the C-terminal region of protein Inscuteable (Insc) containing four putative armadillo repeats and the conserved extreme C-terminal tetrapeptide Glu-Ser-Phe-Val which is in agreement with the class I PDZ-binding motif X-Ser/Thr-X-/ (X and /are unspecified and hydrophobic residues, respectively). Insc functions as an adaptor protein that binds simultaneously with Partner of Insc (Pins, consisting of alpha subunit (Ga) of heterotrimeric G proteins and its guanine nucleotide dissociation inhibitor) and Par3 (PDZ-containing proteins) to regulate their apical localization in neuroblasts, which is required for the correct execution of the asymmetric division.


Pssm-ID: 466076  Cd Length: 394  Bit Score: 584.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860   80 RGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGeiekllmekcselsavterclqvene 159
Cdd:pfam19427   1 RAWIISTELTKIFQKLEKNRWQRVHSTAVRLNCHVRSMISEYSSFARNSSEEMQ-------------------------- 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  160 hvlksmkacvsetlsmlgqhfgqllelaltrevQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALF 239
Cdd:pfam19427  55 ---------------------------------QILVRQIESSDNIYTIESAISSLFSLTQEGAQLCSIIAKEGGVVALF 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  240 KVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFL 319
Cdd:pfam19427 102 KICRQDCFRCLYPHALRTLASICCVEEGINQLEKVDGILCLADILTDETHSEATRAEAAAVVAQITSPHLPFTQHLSSFL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  320 ESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMS 399
Cdd:pfam19427 182 ENMEDIVTALIKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAMKILLEACTDKQRVDTPYSRDQVVTILANMS 261
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  400 VLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSER 479
Cdd:pfam19427 262 VLEQCASDIIQENGIELLMEMLSEKPSSGSPAEVAACERVQQKAAVTLARLSRDPDVARTAIKLNCIPRLIELCRSPAER 341
                         410
                  ....*....|..
gi 767965860  480 NSSDAVLVACLA 491
Cdd:pfam19427 342 NNSDSVLVACLA 353
INSC_LBD cd21966
LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) ...
24-332 3.07e-96

LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) functions as an adapter protein linking the Par polarity complex (composed of Par3, Par6 and protein kinase C iota) to the Gpsm1/Gpsm2 complex, and is involved in cell polarity and spindle orientation during mitosis. Par3 interacts with INSC which binds directly to Pins (partner of Insc, homolog of vertebrate LGN/Gpsm2 and AGS3/Gpsm1). Pins then associates with the heterotrimeric G proteins and NuMA, which interacts directly with the cell spindle to control the orientation of the spindle and the division plane of mitotic cells. INSC may regulate cell proliferation and differentiation in the developing nervous system, may play a role in the asymmetric division of fibroblasts, and may also participate in the process of stratification of the squamous epithelium. This model corresponds to the Leu-Gly-Asn Repeat-Enriched Protein (LGN)-binding domain (LBD) of INSC. It interacts with the tetratricopeptide repeat (TPR) motifs of LGN, also called G-protein-signaling modulator 2 (Gpsm2).


Pssm-ID: 439320 [Multi-domain]  Cd Length: 300  Bit Score: 293.78  E-value: 3.07e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860  24 QVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGgpgPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARV 103
Cdd:cd21966    1 DSDSVQQWLSELRLMTEPECMTTLQSKSIAGEEDQKVKLLVSS---ATDSIRKLQQRAHIISAEFDKLYRKLEKGRWKQV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860 104 HSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQvenehvLKSMKACVSETLSMLGQHFGQL 183
Cdd:cd21966   78 HPLIQSLTGHIRSLLQEYNATLPELPPELQQYEQRLLEICEELRTAAERSLG------SKPNLEELLKLLTTLGQSFSKL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767965860 184 LELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICC 263
Cdd:cd21966  152 VDLLLLKELQILVDSLEEPTSELSLRAALSALTSLGLEGPHLCRLIAKEGGVRALLIVCRDCKSSSVRALALRALATVCC 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767965860 264 VEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKL 332
Cdd:cd21966  232 VPEAIRQFEKAGGIEILSDILTDESRSEPERSEAAGVLAQITSPWIDDNHHLSGLIEHMEDLVKALTRL 300
INSC_LBD pfam16748
Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable ...
23-69 1.28e-24

Inscuteable LGN-binding domain; This is the LGN-binding domain (LBD) of the inscuteable homolog protein. It interacts with the TPR motifs of G-protein-signaling modulator 2 (GPSM2) (LGN) and stabilizes LGN.


Pssm-ID: 465257  Cd Length: 47  Bit Score: 96.14  E-value: 1.28e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767965860   23 MQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPG 69
Cdd:pfam16748   1 IQVDSVQRWMEDLRLMTEVECMCVLQSKPISVEEDAQGELIVSSGHG 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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